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Journal articles on the topic 'Isobaric Ropivacaine Solution'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Boztuğ, N., Z. Bigat, E. Ertok, and M. Erman. "Intrathecal Ropivacaine versus Ropivacaine plus Fentanyl for Out-patient Arthroscopic Knee Surgery." Journal of International Medical Research 33, no. 4 (2005): 365–71. http://dx.doi.org/10.1177/147323000503300401.

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We evaluated the effects of low-dose intrathecal ropivacaine with or without fentanyl for arthroscopic knee surgery. Fifty patients were randomized in equal groups to receive an intrathecal solution (3 ml) containing either 10 mg isobaric ropivacaine or 8 mg isobaric ropivacaine plus 25 μg fentanyl. Complete motor blockade occurred in 22 patients (88%) in both groups. The time taken to reach sensory blockade to T10 and total motor blockade was shorter in the ropivacainetreated group, but differences were not statistically significant. The duration of sensory and motor blockade was shorter in t

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2

Sawant, Kshitija Bhagavan, and Harsha Patel. "Intrathecal ropivacaine with fentanyl for LSCS Comparison of hyperbaric and isobaric solution." Indian Journal of Clinical Anaesthesia 2, no. 3 (2015): 156. http://dx.doi.org/10.5958/2394-4994.2015.00019.0.

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3

I, Kishore Kumar, Shivakumar B.S., and Gangadhar S.B. "A Comparative Evaluation of Hyperbaric Ropivacaine 0.5% (18mg) versus Hyperbaric Bupivacaine 0.5% (18mg) for Elective Lower Abdominal Surgery under Spinal Anaesthesia." International Journal of Pharmaceutical and Clinical Research 16, no. 8 (2024): 102–8. https://doi.org/10.5281/zenodo.13381307.

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<strong>Background:</strong> Ropivacaine is a novel long-acting amide local anaesthetic that is comparable to bupivacaine in terms of its structure and pharmacodynamics. ln comparison to bupivacaine, ropivacaine has a reduced propensity to affect the central nervous system and a lower cardio-toxicity. <strong>Aims and Objectives: </strong>The aim of our study was to compare and assess the effectiveness and compare the block characteristics of hyperbaric ropivacaine 0.5% (18mg) versus hyperbaric bupivacaine 0.5% (18mg) for elective lower abdominal surgeries under spinal Anaesthes

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4

Athyun and Naga Kartheek P. "Comparison of 0.5% Hyperbaric Ropivacaine and 0.5% Hyperbaric Buprenorphine for Elective Surgery under Spinal Anaesthesia." International Journal of Pharmaceutical and Clinical Research 15, no. 3 (2023): 101–7. https://doi.org/10.5281/zenodo.12685653.

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<strong>Background: </strong>Bupivacaine is 40% more powerful than the recently developed ropivacaine. Spinal anesthesia produced hyperbaric with ropivacaine, and dextrose is reported to be effective (SA). In this investigation, the clinical effectiveness of 0.5% bupivacaine and 0.5% ropivacaine for SA was compared at equivalent hyperbaric dosages. <strong>Methods: </strong>A total of n=60 cases were allotted randomly in two groups of n=30 each with Group I receiving intrathecal 15 mg (3 ml) of 0.5% Hyperbaric Bupivacaine. And group II received intrathecal 15 mg (3 ml) of 0.5% H

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5

Gautier, Ph E., M. De Kock, A. Van Steenberge, et al. "Intrathecal Ropivacaine for Ambulatory Surgery." Anesthesiology 91, no. 5 (1999): 1239. http://dx.doi.org/10.1097/00000542-199911000-00013.

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Background The rationale of this study was to evaluate intrathecal ropivacaine for ambulatory surgery. Methods One hundred fifty patients with American Society of Anesthesiologists physical status 1 scheduled for knee arthroscopy were studied. Patients were randomly assigned to receive 4 ml of one of five isobaric intrathecal solutions: Patients in group 1 (n = 30) received 8 mg of bupivacaine; patients in group 2 (n = 30) received 8 mg ropivacaine; patients in group 3 (n = 30) received 10 mg ropivacaine; patients in group 4 (n = 30) received 12 mg ropivacaine; and patients in group 5 (n = 30)

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6

Heller, Axel R., Katrin Zimmermann, Kristin Seele, Thomas Rössel, Thea Koch, and Rainer J. Litz. "Modifying the Baricity of Local Anesthetics for Spinal Anesthesia by Temperature Adjustment." Anesthesiology 105, no. 2 (2006): 346–53. http://dx.doi.org/10.1097/00000542-200608000-00018.

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Background Although local anesthetics (LAs) are hyperbaric at room temperature, density drops within minutes after administration into the subarachnoid space. LAs become hypobaric and therefore may cranially ascend during spinal anesthesia in an uncontrolled manner. The authors hypothesized that temperature and density of LA solutions have a nonlinear relation that may be described by a polynomial equation, and that conversion of this equation may provide the temperature at which individual LAs are isobaric. Methods Density of cerebrospinal fluid was measured using a vibrating tube densitomete

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7

De Kock, Marc, Philippe Gautier, Luc Fanard, Jean Luc Hody, and Patricia Lavand’homme. "Intrathecal Ropivacaine and Clonidine for Ambulatory Knee Arthroscopy." Anesthesiology 94, no. 4 (2001): 574–78. http://dx.doi.org/10.1097/00000542-200104000-00008.

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Background The aim of this study was to evaluate the association of a small dose of intrathecal ropivacaine with small doses of intrathecal clonidine for ambulatory surgery. Methods One hundred twenty patients, classified as American Society of Anesthesiologists physical status I and scheduled for knee arthroscopy, were studied. Patients were randomly assigned to receive 4 ml of one of the following double-blinded isobaric intrathecal solutions: 8 mg of ropivacaine (group 1; n =30); 8 mg ropivacaine plus 15 microg clonidine (group 2; n =30); 8 mg ropivacaine plus 45 microg clonidine (group 3;

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8

Byndoor, Yatish, and Tamilisetti Vidya Sagar. "Levobupivacaine versus ropivacaine in patients undergoing lower abdominal surgeries." Indian Journal of Pharmacy and Pharmacology 10, no. 2 (2023): 111–15. http://dx.doi.org/10.18231/j.ijpp.2023.023.

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Regional anesthesia, like Peripheral nerve block, is commonly used for peripheral surgeries to reduce severe intraoperative and postoperative pain relief. .Some studies with levobupivacaine have shown that duration of analgesia of levobupivacaine are longer compared to that of an equivalent dose of bupivacaine or ropivacaine.This study is done to compare efficacy and safety of levobupivacaine with ropivacaine. In this study we tried to compare efficacy and clinical characteristics of isobaric forms of intrathecal levobupivacaine 0.5% and ropivacaine 0.75% in lower abdominal surgeries.This pros

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9

ARICI, G., N. KAYACAN, F. ERTUGRUL, F. BULUT, Z. BIGAT, and B. KARSLI. "A comparison of isobaric and hyperbaric solutions of ropivacaine undergoing transurethral resection of the prostate surgery." Regional Anesthesia and Pain Medicine 29 (September 2004): 53. http://dx.doi.org/10.1016/j.rapm.2004.07.121.

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10

Arici, G., N. Kayacan, F. Ertugrul, F. Bulut, Z. Bigat, and B. Karsli. "A comparison of isobaric and hyperbaric solutions of ropivacaine undergoing transurethral resection of the prostate surgery." Regional Anesthesia and Pain Medicine 29, Sup 2 (2004): 53. http://dx.doi.org/10.1097/00115550-200409002-00101.

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11

Rajeev, G., Khanderao Nandanwankar Niteen, Chole Minakshi, and V. Kulkarni Vaishnavi. "Comparison of Intrathecal 0.5% Hyperbaric Bupivacaine with 0.5% Hyperbaric Ropivacaine in Infraumbilical Surgeries." International Journal of Pharmaceutical and Clinical Research 16, no. 11 (2024): 360–66. https://doi.org/10.5281/zenodo.14250787.

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<strong>Introduction:</strong> A 0.5% hyperbaric bupivacaine has been extensively used for spinal anaesthesia. It provides an intense motor block, of longer duration which is usually not needed for perineal and lower limb surgeries. Ropivacaine is a relatively new amino-amide local anaesthetic that appears to be less potent and gives less intense motor block of shorter duration as compared to bupivacaine. Ropivacaine also has less cardiovascular and central nervous system toxicity than bupivacaine. It is well established that addition of dextrose to local anaesthetic increases the specifi

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12

McNamee, D. A., L. Parks, A. M. McClelland, et al. "Intrathecal ropivacaine for total hip arthroplasty: double-blind comparative study with isobaric 7.5 mg ml −1 and 10 mg ml −1 solutions." British Journal of Anaesthesia 87, no. 5 (2001): 743–47. http://dx.doi.org/10.1093/bja/87.5.743.

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13

Abbal, Bertrand, Chrystelle Sola, Alain Lacampagne, Christophe Dadure, Sophie Bringuier-Branchereau, and Xavier Capdevila. "Évaluation pharmacodynamique d’une formulation PEG/PLA à libération prolongée de bupivacaïne ou de ropivacaïne versus une solution isobare de bupivacaïne 0,25 % lors d’un bloc de nerf sciatique de rat." Anesthésie & Réanimation 1 (September 2015): A157—A158. http://dx.doi.org/10.1016/j.anrea.2015.07.242.

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14

Bhagyesh Sushchendra Kame, Vaishali U Kumar, and Anand Subramaniam. "Spinal Anaesthesia for Urological Surgery: A Comparison of Isobaric Solutions of Levobupivacaine and Ropivacaine with Dexmedetomidine." Ethiopian Journal of Health Sciences 33, no. 1 (2023). http://dx.doi.org/10.4314/ejhs.v33i1.9.

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BACKGROUND: Subarachnoid block is used in most of urological surgeries and finding the best possible drug has always been a challenge. Bupivacaine’s pure enantiomers ropivacaine and levobupivacaine have lesser systemic toxicity. Isobaric solution has extra benefit of not affecting the intrathecal dispersion of drug. Dexmedetomidine when added intrathecally provides longer duration of analgesia and anaesthesia. Aim of this study is to compare onset, duration of the block with both the drugs along with their hemostability and postoperative analgesia. METHODS: It is a Prospective Randomized Doubl

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15

Ahmad, Langoo S., S. Jan, and T. Ahmad. "Comparative Study between Intrathecal Hyperbaric and Isobaric Ropivacaine in Geriatric Patients, Undergoing Lower Limb Plastic Surgical Procedures." January 19, 2017. https://doi.org/10.19070/2332-2780-1600081.

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Introduction: Ropivacaine is one of the commonest drugs used for spinal anaesthesia. We conducted a study comparing characteristics of spinal anesthesia using isobaric and hyperbaric ropivacaine (0.75%), in geriatric patients who underwent plastic surgical procedures in lower limbs. Study Design: Randomised double blind study. Methods: Sixty Geriatric patients were randomly assigned into two groups (I & H group). Group I patients were given spinal anaesthesia using 15mg of isobaric ropivacaine (0.75%), whereas group H patients were given hyperbaric ropivacaine (0.75%). The characteristics

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16

SHARMA, PRIYANKA, PRIYANKA SAINI, MEGHA SHARMA, and MANISH KHANDELWAL. "A COMPARISON OF INTRAPERITONEAL INSTILLATION OF ROPIVACAINE AND ROPIVACAINE WITH DEXMEDETOMIDINE FOR POSTOPERATIVE ANALGESIA FOLLOWING LAPAROSCOPIC CHOLECYSTECTOMY: A PROSPECTIVE STUDY." International Journal of Current Pharmaceutical Research, January 15, 2024, 36–39. http://dx.doi.org/10.22159/ijcpr.2024v16i1.4011.

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Objective: laparoscopic cholecystectomy surgeries are having advantages over open cholecystectomy with less pain and quick recovery. Intraperitoneal route of administration of a local anaesthetic is a cheap, easy and non-invasive method of reducing the intensity of post laparoscopic pain. This study compared the postoperative analgesic effect of intraperitoneal instillation of ropivacaine 0.5% and ropivacaine 0.5% with dexmedetomidine (1µg/kg) in patients undergoing laparoscopic cholecystectomy under general anaesthesia. Methods: Total 86 patients were divided equally in 2 groups. Patien

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17

Agarwal, Anoop, Vijal Patel, and Himanshu Menat. "COMPARISON OF THE EFFICACY OF INTRATHECAL ISOBARIC ROPIVACAINE AND BUPIVACAINE IN KNEE ARTHROSCOPY: A RANDOMIZED CONTROLLED TRIAL." GLOBAL JOURNAL FOR RESEARCH ANALYSIS, February 15, 2023, 74–76. http://dx.doi.org/10.36106/gjra/9202662.

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A study conducted between two groups to compare intrathecal isobaric Ropivacaine & Bupivacaine in post operative recovery in patients undergoing arthroscopic knee surgery.ASA grade 1&2 patients were randomized into two groups to receive 2ml plain solution either 0.5% bupivacaine (Group B) or 0.75% ropivacaine (Group R).In the intraoperative period,onset,efcacy,duration and regression of sensory and motor block were noted in both the groups at regular intervals. Above mentioned two groups are compared for pain score,recovery prole,analgesic requirement and complications postoperativel

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18

Golfam, Parisa, Mitra Yari, Nahid Prezidend, Bahar Gheitury, and Mansour Rezaei. "A Comparison of Different Doses Efficacy of Isobaric Ropivacaine 0.5% in Spinal Anesthesia in Cesarean Section." Journal of Kermanshah University of Medical Sciences 28, no. 4 (2024). http://dx.doi.org/10.5812/jkums-142126.

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Background: Cesarean delivery is a standard surgical procedure in women. Thus, a practical, affordable, and low-risk anesthetic technique is essential for mother and infant safety. Spinal anesthesia is a popular and efficient technique for anesthesia during cesarean delivery. However, other local anesthesia drugs with negligible side effects should be considered. The most selective medication for this purpose is bupivacaine (marcaine), which creates optimal anesthesia at doses of 10 to 12 mg. Objectives: The most available medicine for spinal anesthesia during cesarean delivery is a 0.5% marin

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19

Marfatia, Gopi Nehul, and Akanksha Raut. "A COMPARATIVE STUDY OF 0.75% HYPERBARIC ROPIVACAINE (3ML) WITH DEXMEDITOMIDINE AS ADJUVANT VS 0.75% HYPERBARIC ROPIVACAINE (3ML) WITHOUT ADJUVANT INTRATHECALLY IN LOWER LIMB SURGERY." INDIAN JOURNAL OF APPLIED RESEARCH, June 1, 2024, 31–33. http://dx.doi.org/10.36106/ijar/1904034.

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Introduction: Lignocaine and Bupivacaine are the drugs used for long time. In this setting one of the newer drug Ropivacaine has emerged and which is available as hyperbaric and isobaric solution. It is used mainly for epidural, subarachnoid block. Ropivacaine was chosen as 0.75% hyperbaric solution for this study. Dexmedetomidine was chosen as an additive to potentate the effects of local anaesthetics. To compare the clinical effects of intra thecal ropiva Objectives: caine and ropivacaine with dexmedetomidine with respect to - 1. Onset of sensory and motor blockade 2. Hemodynamic stability 3

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20

Sharma, Tejash H., Jagrati Jain, Priya Kishnani, Richa Tailor, and Sara Mary Thomas. "Comparison of Hyperbaric 0.5% Levobupivacaine and Hyperbaric 0.75% Ropivacaine for Intrathecal Use in Infraumbilical Surgeries: A Randomised Clinical Study." JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, February 1, 2025. https://doi.org/10.7860/jcdr/2025/76171.20565.

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Introduction: Ropivacaine is a long-acting amide local anaesthetic agent and the pure S (-) enantiomer of propivacaine. It has been readily available as an isobaric solution for a long time. Recently, a hyperbaric solution has become available in the Indian market. Levobupivacaine is the pure S-enantiomer of bupivacaine, which is safer than racemic bupivacaine in regional anaesthesia. It has less affinity and strength of depressant effects on myocardial and Central Nervous System (CNS) vital centers in pharmacodynamic studies, along with a superior pharmacokinetic profile. Aim: To compare the

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21

PW, Nehme, Maalouli JM, Merheb MT, and Gharios EM. "Hyperbaric Bupivacaine for Spinal Anaesthesia in Adults Patients: Comparison of Isobaric Bupivacaine 0.5% in 80mg/Ml and 40 Mg/Ml Glucose Solutions." Austin Journal of Anesthesia and Analgesia 10, no. 2 (2022). http://dx.doi.org/10.26420/austinjanesthesiaandanalgesia.2022.1108.

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Background: The Baricity of bupivacaine is one of the most important factors to influence the characteristics of distribution of the local anaesthetic and spread of the blockade. Bupivacaine is rendered hyperbaric by adding glucose. The effect of differing degrees of hyperbaricity remains to be evaluated in term of spinal anesthesia blockade. Methods: Hundred patients who underwent lower abdominal, hips, and lower extremity surgeries were randomized into two groups in a double-blind, randomised, parallel group, prospective study. Group I received 0.5% isobaric bupivacaine with 80 mg/ml of gluc

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22

"A prospective randomized study comparing 0.5% isobaric solutions of levobupivacaine and ropivacaine with fentanyl as an adjuvant for subarachnoid block in patients undergoing elective lower limb surgery." Indian Journal of Clinical Anaesthesia 5, no. 1 (2018): 102–9. http://dx.doi.org/10.18231/2394-4994.2018.0017.

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