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Relevant bibliographies by topics / Isobologram analysis

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Academic literature on the topic 'Isobologram analysis'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Isobologram analysis"

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Carter, Walter H., Chris Gennings, Joan G. Staniswalis, Eleanor D. Campbell, and Kimber L. White. "A Statistical Approach to the Construction and Analysis of Isobolograms." Journal of the American College of Toxicology 7, no. 7 (1988): 963–73. http://dx.doi.org/10.3109/10915818809014527.

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Current statistical procedures used in the construction of isobolograms do not use recent advances in mathematical statistics. The variability in the experimental data is either ignored or incompletely accounted for in the analyses. The decision procedures currently used to characterize the type of interaction between two agents do not permit the determination of the level of statistical significance associated with a given conclusion. Furthermore, the often formidable sample size is not exploited in the current isobologram methodology. Statistical techniques exist that may be used to construc

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Ujal, Noor Fardziatun, Nurul Izzaty Najwa Zahari, and Nurhidanatasha Abu Bakar. "Ellagic acid, a polyphenolic compound synergistically interacts with concanamycin A, an inhibitor of Plasmodium falciparum proton pump." Asian Journal of Medicine and Biomedicine 8, no. 2 (2024): 90–97. https://doi.org/10.37231/ajmb.2024.8.2.760.

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Background. Ellagic acid is a bioactive phenolic constituent of many plants. Our previous study reported that ellagic acid alkalinised the Plasmodium falciparum digestive vacuole similarly to concanamycin A, a specific inhibitor of V-type H+-ATPase located on the membrane of the malaria parasite’s digestive vacuole. Therefore, this study aimed to determine the interaction of ellagic acid with concanamycin A by using the isobologram analysis of effects on parasite growth. Methodology. A malarial SBYR Green I fluorescence-based (MSF) assay was conducted prior to the isobologram analysis to deter

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Pöch, G., R. J. Reiffenstein, and H. D. Unkelbach. "Application of the isobologram technique for the analysis of combined effects with respect to additivity as well as independence." Canadian Journal of Physiology and Pharmacology 68, no. 6 (1990): 682–88. http://dx.doi.org/10.1139/y90-103.

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Combined actions of two substances with similar effects are frequently expressed by pairs of doses that produce a fixed response, usually 50%, in so-called isobolograms (ED50 isobolograms). In addition to the dose scales in such graphs we propose the addition of effect scales, where possible, to indicate the effect at certain doses, e.g., the ED30. We further propose to construct isoboles for expected independent interaction, in addition to the additivity line, for which purpose a simple procedure is delineated. In practice, an independent isobole for 50% effect passes through the point formed

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Gorka, Alexander P., Lauren M. Jacobs, and Paul D. Roepe. "Cytostatic versus cytocidal profiling of quinoline drug combinations via modified fixed-ratio isobologram analysis." Malaria Journal 12, no. 1 (2013): 332. http://dx.doi.org/10.1186/1475-2875-12-332.

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Xiong, Yin, Hye Kyong Kim, Övgü Çelikler Özer, et al. "Synergistic Inhibiting Effect of Phytochemicals in Rheum palmatum on Tyrosinase Based on Metabolomics and Isobologram Analyses." Molecules 28, no. 3 (2023): 944. http://dx.doi.org/10.3390/molecules28030944.

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Tyrosinase (TYR) plays a key role in the enzymatic reaction that is responsible for a range of unwanted discoloration effects, such as food browning and skin hyperpigmentation. TYR inhibitors could, therefore, be candidates for skin care products that aim to repair pigmentation problems. In this study, we used a metabolomics approach combined with the isobologram analysis to identify anti-TYR compounds within natural resources, and evaluate their possible synergism with each other. Rheum palmatum was determined to be a model plant for observing the effect, of which seven extracts with diverse

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Ozvaran, Mustafa K., Xiaobo X. Cao, Steven D. Miller, Brett A. Monia, Waun Ki Hong, and W. Roy Smythe. "Antisense oligonucleotides directed at the bcl-xl gene product augment chemotherapy response in mesothelioma." Molecular Cancer Therapeutics 3, no. 5 (2004): 545–50. http://dx.doi.org/10.1158/1535-7163.545.3.5.

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Abstract Objective: Malignant pleural mesothelioma (MPM) is resistant to both conventional chemotherapy and apoptosis. The bcl-2 family proteins are major determinants of apoptotic homeostasis. MPM lines and tumors routinely overexpress the anti-apoptotic protein BCL-XL. We have previously shown that antisense inhibition of BCL-XL in MPM cells leads to apoptosis. We sought to determine whether antisense oligonucleotides directed at the bcl-xl gene product would augment response to a conventional chemotherapeutic agent in human mesothelioma cell lines. Methods: The human MPM cell lines REN and

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Khakpoor, Mitra, Mohammad Nasehi, Akbar Vahdati, Seyed-Ebrahim Hoseyni, and Mohammad-Reza Zarrindast. "Additive effect of BLA GABAA receptor mechanism and (+)-MK-801 on memory retention deficit, an isobologram analysis." Pharmacology Biochemistry and Behavior 143 (April 2016): 57–64. http://dx.doi.org/10.1016/j.pbb.2016.02.001.

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Nasehi, Mohammad, Marziyeh Hajikhani, Mohaddeseh Ebrahimi-Ghiri, and Mohammad-Reza Zarrindast. "Interaction between NMDA and CB2 function in the dorsal hippocampus on memory consolidation impairment: an isobologram analysis." Psychopharmacology 234, no. 3 (2016): 507–14. http://dx.doi.org/10.1007/s00213-016-4481-9.

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Tachedjian, G., D. Tyssen, D. Jardine, S. Locarnini, and C. Birch. "Synergistic Inhibition of Human Immunodeficiency Virus Type 1 in vitro by Interferon Alpha and Coumermycin A1." Antiviral Chemistry and Chemotherapy 3, no. 3 (1992): 183–88. http://dx.doi.org/10.1177/095632029200300309.

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Interferon alpha, either leukocyte derived or the recombinant form, and the DNA gyrase inhibitor coumermycin A1 both inhibited human immunodeficiency virus type 1 (HIV) replication in vitro. We have found that combinations of these two agents synergistically inhibited HIV replication in human peripheral blood leucocytes (PBL). Significant inhibition was detected when both virion-associated reverse transcriptase activity and p24 levels were used as markers of replication. Mathematical analysis of data using the procedure of Chou and Chou (1987) produced combination indices of less than 1.0 for

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Kifer, Domagoj, Daniela Jakšić, and Maja Šegvić Klarić. "Assessing the Effect of Mycotoxin Combinations: Which Mathematical Model Is (the Most) Appropriate?" Toxins 12, no. 3 (2020): 153. http://dx.doi.org/10.3390/toxins12030153.

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In the past decades, many studies have examined the nature of the interaction between mycotoxins in biological models classifying interaction effects as antagonisms, additive effects, or synergisms based on a comparison of the observed effect with the expected effect of combination. Among several described mathematical models, the arithmetic definition of additivity and factorial analysis of variance were the most commonly used in mycotoxicology. These models are incorrectly based on the assumption that mycotoxin dose-effect curves are linear. More appropriate mathematical models for assessing

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Book chapters on the topic "Isobologram analysis"

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Wagenpfeil, Stefan, Uwe Treiber, and Antonie Lehmer. "Isobologram Analysis in MATLAB for Combined Effects of Two Agents in Dose-Response Experiments." In Medical Data Analysis. Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-540-39619-2_7.

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Carter, Walter H., and Chris Gennings. "Analysis of Chemical Combinations: Relating Isobolograms to Response Surfaces." In Toxicology of Chemical Mixtures. Elsevier, 1994. http://dx.doi.org/10.1016/b978-0-12-768350-8.50030-x.

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Conference papers on the topic "Isobologram analysis"

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Hamann, C., O. Jansen, P. Desdemoustier, A. Ledoux, E. Maquoi, and M. Frederich. "Characterization of the type of interaction between terpenoids and cannabinoids compounds of hemp plant against MDA-MB-231 cancer-cells by isobologram analyses." In GA – 70th Annual Meeting 2022. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1759208.

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