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Journal articles on the topic 'Isoflavona de soja'

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Published: 4 June 2021

Last updated: 14 February 2022

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Dalpizol, Bruna, Eduarda Lehr, Gabriela Beacker Alves, Fernanda Rodrigues, and Daniela Miotto Bernardi. "PROPRIEDADES FUCIONAIS DA SOJA." FAG JOURNAL OF HEALTH (FJH) 2, no. 3 (2020): 394–401. http://dx.doi.org/10.35984/fjh.v2i3.230.

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A soja é a leguminosa mais consumida no mundo atualmente, e é conhecida por suas propriedades anti-inflamatórias e antioxidantes que em grande parte são devidas a isoflavona presente em sua composição. Neste contexto o presente artigo de revisão tem como objetivo avaliar os efeitos do consumo da soja e discutir seu uso na indústria de alimentos. Foram utilizados resultados de 150 estudos comparados entre si para discutir os efeitos benéficos e promissores dos princípios bioativos da soja. Considerando os resultados coletados e comparados, pode-se concluir que a soja possui efeitos positivos no controle dos sintomas da menopausa, e diminui o crescimento de neoplasias, devido a sua alta atividade antioxidante, mas devem ser realizados mais estudos randomizados para comprovação científica dos seus benefícios.

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Mantovani, Daniel, Aline Takaoka Alves Baptista, Charleston De Oliveira Bezerra, Driano Rezende, Luis Fernando Cusioli, and Paulo Fernando Soares. "MÉTODO DE VALIDAÇÃO E SEPARAÇÃO DE ISOFLAVONAS PRESENTES EM MELAÇO DE SOJA." e-xacta 11, no. 1 (2018): 97. http://dx.doi.org/10.18674/exacta.v11i1.2347.

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As isoflavonas atuam no organismo humano com efeitos fisiológicos de forma benéfica tornando os alimentos que contém isoflavonas em formas funcionais ao organismo. Assim, neste trabalho foi desenvolvido um método de análise por Cromatografia Líquida de Alta Eficiência (CLAE) bem como, separação e quantificação de isoflavonas presentes no melaço de soja. A validação do método foi baseada pela linearidade, limite de detecção (LD) e limite de quantificação (LQ) com estabelecimentos de critérios de análise para aceitação da metodologia proposta. Os resultados obtidos na separação dos isômeros de isoflavonas bem como a quantificação trouxeram melhorias relacionadas ao tempo de retenção de cada isômero estudado e separação dos compostos. Com relação ao método aplicado ao longo do estudo este apresentou resultados pertinentes para utilização e expansão do método proposto focado nos compostos de isoflavonas formas glicosídicas e agliconas presentes no melaço de soja. ABSTRACTIsoflavones act in the human body with physiological effects in a beneficial way making foods containing isoflavones in functional forms to the body. Thus, in this work a high efficiency liquid chromatography (HPLC) analysis method was developed, as well as, separation and quantification of isoflavones from in soybean molasses. The validation of the method was based on linearity, limit of detection (LD) and limit of quantification (LQ) with establishments of analysis criteria for acceptance of the proposed methodology. The results obtained in the separation of the isoflavone isomers as well as the quantification brought improvements related to the retention time of each studied isomer and separation of the compounds. In relation to the method applied throughout the study, it presented relevant results for the use and expansion of the proposed method focused on the isoflavone compounds glycosidic forms and aglycones from soybean molasses.

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Vergne, Sébastien, Catherine Bennetau-Pelissero, Valérie Lamothe, et al. "Higher bioavailability of isoflavones after a single ingestion of a soya-based supplement than a soya-based food in young healthy males." British Journal of Nutrition 99, no. 2 (2008): 333–44. http://dx.doi.org/10.1017/s0007114507803953.

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Soya isoflavones, genistein and daidzein, are the focus of numerous studies investigating their potential effects on health and results remain controversial. Bioavailability is clearly a crucial factor influencing their bioefficacy and could explain these discrepancies. This study aimed at assessing: (1) the isoflavone content of sixty-nine European soya-derivative products sold on the French market; (2) the bioavailability of isoflavones comparing supplement with food. Twelve healthy volunteers were recruited in a randomized two-way crossover trial and received 35 mg isoflavones equivalent aglycone either through supplements or through cheese, both containing different patterns of isoflavone conjugates and different daidzein:genistein ratios. A specific ELISA method was used to assess the plasma and urinary concentrations of isoflavones and thus the pharmacokinetic parameters, which were then normalized to mg of each isoflavone ingested. Results showed that the normalized Cmax of daidzein (P = 0·002) and similarly the normalized AUC0 → ∞andCmaxof genistein (P = 0·002) from soya-based capsules were higher than that from soya-based cheese. In conclusion, this work completes studies on isoflavone bioavailability and presents new data regarding isoflavone concentrations in soya-derivative products. Assuming that isoflavone conjugation patterns do not influence isoflavone bioavailability, this study shows that isoflavones contained in capsules are more bioavailable than those contained in soya-based cheese. Although the supplement is more bioavailable, the relative importance of this is difficult to interpret as there is little evidence that supplements are biologically active in human subjects to date and further studies will be necessary for this specific supplement to prove its efficacy.

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Silva, Carlos Eduardo da, Mercedes Concórdia Carrão-Panizzi, José Marcos Gontijo Mandarino, Rodrigo Santos Leite, and Ana Paula do Amaral Mônaco. "Teores de isoflavonas em grãos inteiros e nos componentes dos grãos de diferentes cultivares de soja (Glycine max (L.) Merrill)." Brazilian Journal of Food Technology 15, no. 2 (2012): 150–56. http://dx.doi.org/10.1590/s1981-67232012005000008.

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Devido à maior concentração de isoflavonas nos hipocótilos dos grãos de soja, a indústria de alimentos tem utilizado esse componente do grão como matéria-prima. No presente trabalho, foram quantificados os teores de isoflavonas nas estruturas formadoras do grão de soja (hipocótilo, cotilédones e casca), analisadas por Cromatografia Líquida de Alta Eficiência (CLAE). Foram avaliadas quatro cultivares de sojas especiais: BRS 184, BRS 216, BRS 257 e BRS 267, desenvolvidas pela Embrapa Soja. Todas as cultivares apresentaram maior teor de isoflavonas totais no hipocótilo (média de 2029,32 mg.100 g-1). No grão inteiro (267,16 mg.100 g-1) e nos cotilédones (209,16 mg.100 g-1), os teores de isoflavonas foram cerca de dez vezes menores do que nos hipocótilos. A cultivar BRS 216 apresentou o teor maior de isoflavonas totais no hipocótilo (2583,20 mg.100 g-1). Embora a casca da soja não apresente isoflavonas, observou-se que esses compostos estavam presentes nessa parte do grão numa quantidade média de 105,58 mg.100 g-1, devido à presença de resíduos do hipocótilo e dos cotilédones provenientes do processo de descasque. Essa composição residual da casca favorece sua utilização como matéria-prima fonte de fibras, porque também fornece isoflavonas e outros compostos da soja.

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Thorp, Alicia A., Natalie Sinn, Jonathan D. Buckley, Alison M. Coates, and Peter R. C. Howe. "Soya isoflavone supplementation enhances spatial working memory in men." British Journal of Nutrition 102, no. 9 (2009): 1348–54. http://dx.doi.org/10.1017/s0007114509990201.

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Females perform better in certain memory-related tasks than males. Sex differences in cognitive performance may be attributable to differences in circulating oestrogen acting on oestrogen β receptors (ERβ) which are prevalent in brain regions such as the hippocampus, frontal lobe and cortex that mediate cognitive functions. Since soya isoflavones are known to activate ERβ, chronic isoflavone supplementation in males may improve cognitive performance in memory-related tasks. A 12-week double-blind, placebo-controlled cross-over trial was conducted in thirty-four healthy men to investigate the effect of isoflavone supplementation on cognitive function. Volunteers were randomised to take four capsules/d containing soya isoflavones (116 mg isoflavone equivalents/d: 68 mg daidzein, 12 mg genistein, 36 mg glycitin) or placebo for 6 weeks, and the alternate treatment during the following 6 weeks. Assessments of memory (verbal episodic, auditory and working), executive function (planning, attention, mental flexibility) and visual-spatial processing were performed at baseline and after each treatment period. Isoflavone supplementation significantly improved spatial working memory (P = 0·01), a test in which females consistently perform better than males. Compared with placebo supplementation, there were 18 % fewer attempts (P = 0·01), 23 % fewer errors (P = 0·02) and 17 % less time (P = 0·03) required to correctly identify the requisite information. Isoflavones did not affect auditory and episodic memory (Paired Associate Learning, Rey's Auditory Verbal Learning Task, Backward Digit Span and Letter-Number Sequencing), executive function (Trail Making and Initial Letter Fluency Task) or visual-spatial processing (Mental Rotation Task). Isoflavone supplementation in healthy males may enhance cognitive processes which appear dependent on oestrogen activation.

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Hallund, J., S. Bügel, T. Tholstrup, et al. "Soya isoflavone-enriched cereal bars affect markers of endothelial function in postmenopausal women." British Journal of Nutrition 95, no. 6 (2006): 1120–26. http://dx.doi.org/10.1079/bjn20061734.

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Soya isoflavones are thought to be cardioprotective due to their structural similarity to oestrogen. In order to investigate the effect of soya isoflavones on markers of endothelial function we conducted a randomised, double-blind, placebo-controlled, cross-over study with thirty healthy postmenopausal women. The women consumed cereal bars, with or without soya isoflavones (50mg/d), for 8 weeks, separated by an 8-week washout period. Systemic arterial complince (SAC), isobaric arterial compliance (IAC), flow-mediated endothelium-dependent vasodilation (FMD) and nitroglycerine-mediated endothelium-independent vasodilation (NMD) were measured at the beginning of the study and after each intervention period. Blood pressure (BP) and plasma concentrations of nitrite and nitrate (NOx) and endothelin-1 (ET-1) were measured at the beginning and end of each intervention period.NMD was 13·4 (sem 2·0) % at baseline and 15·5 (sem 1·1) % after isoflavone treatment compared with 12·4 (sem 1·0) % after placebo treatment (P=0·03). NOx increased from 27·7 (sem 2·7) to 31·1 (sem 3·2) μm after isoflavones treatment compared with 25·4 (sem 1·5) to 20·4 (sem 1·1) μm after placebo treatment (P=0·003) and a significant increase in the NOx:ET-1 ratio (P=0·005) was observed after the isoflavone treatment compared with placebo. A significant difference in SAC after the isoflavone and placebo treatment was observed (P=0·04). No significant difference was found in FMD, IAC, BP and ET-1. In conclusion, 8 weeks' consumption of cereals bars enriched with 50mg soya isoflavones/d increased plasma NOx concentrations and improved endothelium-independent vasodilation in healthy postmenopausal women.

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Halm, Brunhild M., Leslie A. Ashburn, and Adrian A. Franke. "Isoflavones from soya foods are more bioavailable in children than adults." British Journal of Nutrition 98, no. 5 (2007): 998–1005. http://dx.doi.org/10.1017/s0007114507771866.

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The purpose of the present study was to determine whether children experience a higher systemic exposure to isoflavonoids when consuming a body weight-adjusted dose of soya compared with adults. Forty study participants were recruited from a local Waldorf school, including twenty-one children and nineteen adults. Participants collected a baseline urine sample and ate immediately thereafter a body weight-adjusted dose of soya nuts (15 g/54·4 kg equivalent to 0·615 (sd 0·036) mg total isoflavones/kg) followed by a 12 h urine collection. Nineteen children and eighteen adults completed the protocol correctly (fourteen child–parent pairs). Children, compared with adults, showed a statistically significant (P < 0·05 by unpaired t test) higher urinary isoflavone excretion rate for daidzein (+39 %), genistein (+44 %), all non-metabolites (daidzein + genistein + glycitein; +41 %) and total isoflavonoids (+32 %). Isoflavones are more bioavailable in children v. adults. Urine is an excellent medium to determine systemic isoflavone exposure in children due to its non-invasiveness and high compliance, in particular when collected overnight; it also allows evaluation of completeness of specimen collection.

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Park, Y. K., C. L. Aguiar, S. M. Alencar, H. A. A. Mascarenhas, and A. R. P. Scamparini. "AVALIAÇÃo DO TEOR DE ISOFLAVONAS EM SOJA BRASILEIRA SURVEY OF ISOFLAVONE CONTENTS IN BRAZILIAN SOYBEAN EVALUACIÓN DEL CONTENIDO DE ISOFLAVONAS EN SOJA BRASILEIRA." Ciencia y Tecnologia Alimentaria 3, no. 3 (2001): 156–60. http://dx.doi.org/10.1080/11358120109487723.

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Webb, Carolyn M., Christopher S. Hayward, Mark J. Mason, Charles D. Ilsley, and Peter Collins. "Coronary vasomotor and blood flow responses to isoflavone-intact soya protein in subjects with coronary heart disease or risk factors for coronary heart disease." Clinical Science 115, no. 12 (2008): 353–59. http://dx.doi.org/10.1042/cs20070443.

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Results in animals suggest favourable coronary vasomotor actions of isoflavones; however, the effects of isoflavones on the human coronary circulation have not been determined. In the present study, we therefore investigated the effects of short-term isoflavone-intact soya protein ingestion on basal coronary arterial tone and stimulated vasoreactivity and blood flow in patients with CHD (coronary heart disease) or risk factors for CHD. Seventy-one subjects were randomized, double-blind, to isoflavone-intact soya protein [active; n=33, aged 58±8 years (mean±S.D.)] or isoflavone-free placebo (n=38, aged 61±8 years) for 5 days prior to coronary angiography. In 25 of these subjects, stimulated coronary blood flow was calculated from flow velocity, measured using intracoronary Doppler and coronary luminal diameter before and after intracoronary adenosine, ACh (acetylcholine) and ISDN (isosorbide dinitrate) infusions. Basal and stimulated coronary artery luminal diameters were measured using quantitative coronary angiography. Serum concentrations of the isoflavones genistein, daidzein and equol were increased by active treatment (P<0.001, P<0.001 and P=0.03 respectively). Basal mean luminal diameter was not significantly different between groups (active compared with placebo: 2.9±0.7 compared with 2.73±0.44 mm, P=0.31). There was no difference in luminal diameter, flow velocity and volume flow responses to adenosine, ACh or ISDN between groups. Active supplement had no effect on basal coronary artery tone or stimulated coronary vasoreactivity or blood flow compared with placebo. Our results suggest that short-term consumption of isoflavone-intact soya protein is neither harmful nor beneficial to the coronary circulation of humans with CHD or risk factors for CHD. These results are consistent with recent cautions placed on the purported health benefits of plant sterols.

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Gobert, Colleen P., Elizabeth A. Pipe, Sarah E. Capes, Gerarda A. Darlington, Johanna W. Lampe, and Alison M. Duncan. "Soya protein does not affect glycaemic control in adults with type 2 diabetes." British Journal of Nutrition 103, no. 3 (2009): 412–21. http://dx.doi.org/10.1017/s0007114509991802.

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Evidence from observational, animal and human studies supports a role for soya protein and its isoflavones in the improvement of glycaemic control in type 2 diabetes. The objective of the present study was to determine the effect of isoflavone-rich soya protein on markers of glycaemic control in adults with type 2 diabetes. Using a randomised, crossover, double-blind, placebo-controlled design, adults with diet-controlled type 2 diabetes (n 29) consumed soya protein isolate (SPI) and milk protein isolate (MPI) for 57 d each separated by a 4-week washout. Blood was collected on days 1 and 57 of each treatment period for analysis of fasting HbA1C, and fasting and postprandial glucose, insulin and calculated indices of insulin sensitivity and resistance. Urine samples of 24 h were collected at the end of each treatment period for analysis of isoflavones. Urinary isoflavone excretion was significantly greater following consumption of SPI compared with MPI, and 20·7 % of the subjects (n 6) were classified as equol excretors. SPI consumption did not significantly affect fasting or postprandial glucose or insulin, fasting HbA1C, or indices of insulin sensitivity and resistance. These data do not support a role for soya protein in the improvement of glycaemic control in adults with diet-controlled type 2 diabetes and contribute to a limited literature of human studies on the effects of soya protein on the management of type 2 diabetes.

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Müller, Thomas. "Isoflavone verdächtigt: Kopfschmerz durch Soja?" Angewandte Schmerztherapie und Palliativmedizin 7, no. 4 (2014): 14. http://dx.doi.org/10.1007/s15223-014-0456-z.

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Leithardt, Daiana Rosso Ferreira, Aline Naomi Yamashita, and Adelaide Del Pino Beléia. "Determinação de isoflavonas e antocianinas em soja preta." Brazilian Journal of Food Research 9, no. 3 (2018): 112. http://dx.doi.org/10.3895/rebrapa.v9n3.5929.

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A soja preta [Glycine max (L.) Merrill] é uma variedade de soja pouco conhecida no Brasil, que além de possuir os benefícios relacionados ao consumo da soja, apresenta antocianinas na casca, auxiliando na atividade antioxidante. Grande parte da literatura científica refere-se à soja amarela, enquanto estudos sobre a soja preta ainda são escassos. O objetivo desse estudo foi analisar grãos de soja preta e amarela, crus e cozidos, quanto ao teor dos principais compostos bioativos. A identificação e quantificação de isoflavonas por CLUE, e antocianinas pelo método do pH diferencial. Os teores de antocianinas totais nos grãos de soja preta sofreram uma redução de 83% após o cozimento. Cinco das doze formas químicas de isoflavonas foram detectadas e quantificadas nos grãos de soja preta e amarela, crus e cozidos. A forma malonilglicosídica apresentou a maior concentração nas duas cultivares, e após o cozimento houve um acréscimo da forma aglicona nas cultivares de soja preta e amarela. Assim, o consumo de soja preta ou mesmo a produção de novos alimentos a partir desses grãos poderá oferecer ao consumidor a possibilidade de diversificar a sua dieta, introduzindo um alimento com a mesma qualidade nutricional da soja amarela e, possivelmente, maiores benefícios à saúde.

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ESTEVES, Elizabeth Adriana, and Josefina Bressan Resende MONTEIRO. "Efeitos benéficos das isoflavonas de soja em doencas crônicas." Revista de Nutrição 14, no. 1 (2001): 43–52. http://dx.doi.org/10.1590/s1415-52732001000100007.

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Durante as últimas décadas, evidências científicas vêm demonstrando que as isoflavonas podem trazer benefícios no controle de doenças crônicas tais como câncer, diabetes mellitus, osteoporose e doenças cardiovasculares. Estes compostos estão amplamente distribuídos no reino vegetal e concentrações relativamente maiores são encontradas nas leguminosas, em particular, na soja (Glycne max). Além da sua atividade anti-estrogênica, possuem diversas propriedades biológicas que podem afetar muitos processos bioquímicos e fisiológicos. As evidências de que as isoflavonas protegem contra várias doenças crônicas são baseadas em estudos experimentais e epidemiológicos. Em humanos, estudos epidemiológicos mostram uma maior incidência de alguns tipos de câncer (mama, próstata e cólon) e doenças cardiovasculares nas populações ocidentais expostas a limitadas quantidades de isoflavonas de soja na dieta. Evidência adicional para proteção contra o câncer e doenças cardíacas tem sido verificada em vários modelos experimentais com animais. As isoflavonas podem também prevenir a perda óssea pós-menopausa e a osteoporose. Efeitos da genisteína na regulação da secreção de insulina também têm sido demonstrados. Os mecanismos pelos quais as isoflavonas podem exercer estes efeitos parecem depender, em parte, das suas propriedades agonistas-antagonistas dos estrógenos. Outros mecanismos hipotéticos poderiam derivar de outras propriedades bioquímicas, tais como inibição da atividade enzimática e efeito antioxidante.

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Cai, Yun, Kaiping Guo, Chaogang Chen, et al. "Soya isoflavone consumption in relation to carotid intima–media thickness in Chinese equol excretors aged 40–65 years." British Journal of Nutrition 108, no. 9 (2012): 1698–704. http://dx.doi.org/10.1017/s0007114511007331.

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Previous studies have suggested that the daidzein metabolite equol rather than daidzein itself contributes to the beneficial effect of soya foods in the prevention of CVD. The aim of the present study is to examine the proportion of equol excretion in Chinese adults and compare plasma lipids and carotid artery intima–media thickness (IMT) between equol excretors and non-excretors, and to evaluate the effect of soya isoflavone intakes on serum lipids and IMT in either equol excretors or non-excretors. Subjects (n 572; women n 362, men n 210) were recruited for the present study. An overnight urine sample was provided by each subject on their usual diet to quantify urinary concentrations of daidzein and equol. Far-wall IMT was determined by B-mode ultrasound in the right carotid at two sites, carotid bulb (CB-IMT) and common carotid artery (CCA-IMT), and fasting serum lipids were measured. Habitual dietary intakes were estimated with a FFQ, and soya isoflavone intake derived from the FFQ was assessed. Of the 572 subjects, the proportion of equol excretors on their usual diet was 25·0 % (n 143). Compared with non-excretors, equol excretors showed significantly lower serum TAG ( − 38·2 (95 % CI − 70·4, − 5·9) %, P = 0·012) and CCA-IMT ( − 4·9 (95 % CI − 9·7, − 0·3) %, P = 0·033). Equol excretors with higher daily isoflavone intakes ( − 5·4 mg/d) had significantly lower IMT ( − 16·2 %, P = 0·035) and tended to have higher HDL-cholesterol (P = 0·055) than did those with lower daily isoflavone intakes (1·5 mg/d), while no association was observed between soya isoflavone intakes and serum lipids or IMT in non-excretors. In conclusion, the benefits of soya isoflavones in preventing CVD may be apparent among equol excretors only.

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Lygin, Anatoliy V., Olga V. Zernova, Curtis B. Hill, et al. "Glyceollin is an Important Component of Soybean Plant Defense Against Phytophthora sojae and Macrophomina phaseolina." Phytopathology® 103, no. 10 (2013): 984–94. http://dx.doi.org/10.1094/phyto-12-12-0328-r.

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The response of soybean transgenic plants, with suppressed synthesis of isoflavones, and nontransgenic plants to two common soybean pathogens, Macrophomina phaseolina and Phytophthora sojae, was studied. Transgenic soybean plants of one line used in this study were previously generated via bombardment of embryogenic cultures with the phenylalanine ammonia lyase, chalcone synthase, and isoflavone synthase (IFS2) genes in sense orientation driven by the cotyledon-preferable lectin promoter (to turn genes on in cotyledons), while plants of another line were newly produced using the IFS2 gene in sense orientation driven by the Cassava vein mosaic virus constitutive promoter (to turn genes on in all plant parts). Nearly complete inhibition of isoflavone synthesis was found in the cotyledons of young seedlings of transgenic plants transformed with the IFS2 transgene driven by the cotyledon-preferable lectin promoter compared with the untransformed control during the 10-day observation period, with the precursors of isoflavone synthesis being accumulated in the cotyledons of transgenic plants. These results indicated that the lectin promoter could be active not only during seed development but also during seed germination. Downregulation of isoflavone synthesis only in the seed or in the whole soybean plant caused a strong inhibition of the pathogen-inducible glyceollin in cotyledons after inoculation with P. sojae, which resulted in increased susceptibility of the cotyledons of both transgenic lines to this pathogen compared with inoculated cotyledons of untransformed plants. When stems were inoculated with M. phaseolina, suppression of glyceollin synthesis was found only in stems of transgenic plants expressing the transgene driven by a constitutive promoter, which developed more severe infection. These results provide further evidence that rapid glyceollin accumulation during infection contributes to the innate soybean defense response.

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Góes-Favoni, Silvana Pedroso de, Adelaide Del Pino Beléia, Mercedes C. Carrão-Panizzi, and José Marcos Gontijo Mandarino. "Isoflavonas em produtos comerciais de soja." Ciência e Tecnologia de Alimentos 24, no. 4 (2004): 582–86. http://dx.doi.org/10.1590/s0101-20612004000400017.

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Ávila, Marizangela Rizzatti, Alessandro de Lucca e. Braccini, Carlos Alberto Scapim, José Marcos Gontijo Mandarino, Leandro Paiola Albrecht, and Pedro Soares Vidigal Filho. "Componentes do rendimento, teores de isoflavonas, proteínas, óleo e qualidade de sementes de soja." Revista Brasileira de Sementes 29, no. 3 (2007): 111–27. http://dx.doi.org/10.1590/s0101-31222007000300014.

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A soja, além de ser utilizada na alimentação animal vem sendo incluída na alimentação humana, pois possui na sua composição química, proteínas, lipídios, algumas vitaminas e compostos polifenólicos, como as isoflavonas. A atividade antioxidante das isoflavonas pode ser considerada um mecanismo de garantia da qualidade das sementes, em virtude da teoria de deterioração, em detrimento da ação de radicais livres na membrana celular. Desta forma, conduziu-se um experimento durante o ano agrícola de 2004/05 em dois locais de semeadura (Maringá e Umuarama), com o objetivo avaliar os componentes de produção, a qualidade fisiológica das sementes de soja produzidas em dois locais de semeadura e determinar os seus teores de óleo, proteínas e de isoflavonas, bem como correlacionar o conteúdo de isoflavonas com os componentes de rendimento, qualidade fisiológica, teores de óleo e proteínas das sementes de soja. As cultivares estudadas foram de ciclo precoce (EMBRAPA 48 e BRS 213) e semiprecoce (BR 36, BRS 133, BRS 184 e BRS 214). Avaliou-se o rendimento e a massa de mil sementes, a qualidade das sementes por meio dos testes de germinação (primeira contagem e contagem final), tetrazólio (vigor e viabilidade) e o teor de óleo, proteínas e isoflavonas. Verificou-se que as cultivares BRS 133 e EMBRAPA 48 apresentaram os maiores conteúdos de isoflavonas, ao passo que, para a cultivar BR 36, foi constatada a menor quantidade, em ambos os locais. Para todas as cultivares avaliadas em Maringá, a germinação das sementes foi superior a 80%. A correlação entre isoflavonas e massa de mil sementes foi negativa para as duas localidades.

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Sarasquete, C., M. Úbeda-Manzanaro, and JB Ortiz-Delgado. "Soya isoflavones, genistein and daidzein, induce differential transcriptional modulation in the ovary and testis of zebrafish Danio rerio." Aquatic Biology 29 (April 30, 2020): 79–91. http://dx.doi.org/10.3354/ab00726.

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Most research into the effects of phytochemical isoflavones has focussed on endocrine disruptions, and especially on oestrogenic imbalances; however, little is known about their effects on other molecular signals such as transcriptional coregulators and choriolytic enzymatic pathways, which are also important in reproductive processes. In male and female zebrafish Danio rerio, the soya isoflavones genistein and daidzein (provided at 10 mg l-1 for 15 d) modulated the basal expression levels of oestrogen receptor transcripts (ERβ) in variable and differential ways. Exposure to genistein resulted in decreased levels of ERβ in the zebrafish ovary; conversely, this isoflavone increased the basal expression levels of the hatching enzyme (HE1) in both gonads. On the other hand, daidzein increased the basal expression levels of the bromodomain testis-specific gene (BRDT) in the male gonad, but not in the ovary. Both isoflavones also differentially modulated (up-down regulations) the basal expression patterns of the 3 molecular signals studied in other regions of the body (e.g. head, digestive system, skeletal musculature). Despite all these transcriptional imbalances, neither of the phytoestrogens modified gonadal histomorphology or the baseline histochemical pattern of proteins, carbohydrates and glycoconjugates distributed in either the vitelline structures or in the developing and maturing germ cells of Danio rerio.

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Tang, Li, Andy H. Lee, Fenglian Xu, Taotao Zhang, Jun Lei, and Colin W. Binns. "Soya and isoflavone intakes associated with reduced risk of oesophageal cancer in north-west China." Public Health Nutrition 18, no. 1 (2014): 130–34. http://dx.doi.org/10.1017/s1368980013003443.

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AbstractObjectiveTo ascertain the association between soya consumption, isoflavone intakes and oesophageal cancer risk in remote north-west China, where the incidence of oesophageal cancer is known to be high.DesignCase–control study. Information on habitual consumption of soya foods and soya milk was obtained by personal interview. The intakes of isoflavones were then estimated using the US Department of Agriculture nutrient database. Logistic regression analyses were performed to assess the association between soya consumption, isoflavone intakes and oesophageal cancer risk.SettingUrumqi and Shihezi, Xinjiang Uyghur Autonomous Region, China.SubjectsParticipants were 359 incident oesophageal cancer patients and 380 hospital-based controls.ResultsThe oesophageal cancer patients consumed significantly less (P < 0·001) total soya foods (mean 57·2 (sd 119·0) g/d) and soya milk (mean 18·8 (sd 51·7) ml/d) than the controls (mean 93·3 (sd 121·5) g/d and mean 35·7 (sd 73·0) ml/d). Logistic regression analyses showed an inverse association between intake of soya products and the risk of oesophageal cancer. The adjusted odds were OR = 0·33 (95 % CI 0·22, 0·49) and OR = 0·48 (95 % CI 0·31, 0·74) for consuming at least 97 g of soya foods and 60 ml of soya milk daily (the highest tertiles of consumption), respectively, relative to the lowest tertiles of consumption. Similarly, inverse associations with apparent dose–response relationships were found between isoflavone intakes and oesophageal cancer risk.ConclusionsHabitual consumption of soya products appears to be associated with reduced risk of oesophageal cancer in north-west China.

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Chai, Chuan, Xiaobing Cui, Chenxiao Shan, Sheng Yu, Xinzhi Wang, and Hongmei Wen. "Simultaneous Characterization and Quantification of Varied Ingredients from Sojae semen praeparatum in Fermentation Using UFLC–TripleTOF MS." Molecules 24, no. 10 (2019): 1864. http://dx.doi.org/10.3390/molecules24101864.

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Systematic comparison of active ingredients in Sojae semen praeparatum (SSP) during fermentation was performed using ultra-fast liquid chromatography (UFLC)–TripleTOF MS and principal component analysis (PCA). By using this strategy, a total of 25 varied compounds from various biosynthetic groups were assigned and relatively quantified in the positive or negative ion mode, including two oligosaccharides, twelve isoflavones, eight fatty acids, N–(3–Indolylacetyl)–dl–aspartic acid, methylarginine, and sorbitol. Additionally, as the representative constituents, six targeted isoflavones were sought in a targeted manner and accurately quantified using extracted ion chromatograms (XIC) manager (AB SCIEX, Los Angeles, CA, USA) combined with MultiQuant software (AB SCIEX, Los Angeles, CA, USA). During the fermentation process, the relative contents of oligoses decreased gradually, while the fatty acids increased. Furthermore, the accurate contents of isoflavone glycosides decreased, while aglycones increased and reached a maximum in eight days, which indicated that the ingredients converted obviously and regularly throughout the SSP fermentation. In combination with the morphological changes, which meet the requirements of China Pharmacopoeia, this work suggested that eight days is the optimal time for fermentation of SSP from the aspects of morphology and content.

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Yee Chan, Ho, and Lai K. Leung. "A potential protective mechanism of soya isoflavones against 7,12-dimethylbenz[a]anthracene tumour initiation." British Journal of Nutrition 90, no. 2 (2003): 457–65. http://dx.doi.org/10.1079/bjn2003913.

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Epidemiological studies indicate that Asian women have a lower breast cancer incidence compared with their counterparts in the West, and the difference has been related to soya consumption. Animal studies have suggested that soya may prevent dimethylbenz[a]anthracene (DMBA)-induced carcinogenesis in the breast. In the present study a cell culture model was developed to address the effect of soya isoflavones on the DMBA-induced DNA damage. DMBA is metabolized into a DNA-attacking moiety by two phase I cytochrome P450 (CYP) enzymes CYP1A1 and CYP1B1. DNA mutation caused by this genotoxic agent is a crucial step in cancer initiation. Substances that interfere with the CYP1 enzyme activities can affect the initiation. In the present study, genistein was found to be an effective inhibitor of recombinant human CYP1A1 and CYP1B1 with Ki of 15·35 and 0·68 μmol/l. The other soya isoflavone daidzein, on the other hand, did not demonstrate any significant inhibition of the enzyme activities. At the transcriptional level, DMBA induced the CYP1 enzyme expressions by stimulating the xenobiotic response element (XRE)-dependent transactivation pathway. When genistein (25 μmol/l) was co-administered with DMBA, the XRE-Luc activity the CYP1 mRNA abundances were significantly suppressed. The present study illustrated that the soya isoflavone genistein, but not daidzein, protected against DMBA genotoxicity.

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GENOVESE, Maria Inés, and Franco M. LAJOLO. "Determinação de isoflavonas em derivados de soja." Ciência e Tecnologia de Alimentos 21, no. 1 (2001): 86–93. http://dx.doi.org/10.1590/s0101-20612001000100019.

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Carrão-Panizzi, Mercedes Concórdia, Aline Silva Simão, and Akio Kikuchi. "Efeitos de genótipos, ambientes e de tratamentos hidrotérmicos na concentração de isoflavonas agliconas em grãos de soja." Pesquisa Agropecuária Brasileira 38, no. 8 (2003): 897–902. http://dx.doi.org/10.1590/s0100-204x2003000800001.

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O objetivo deste trabalho foi avaliar os efeitos de tratamentos hidrotérmicos, da variabilidade genética e de ambientes no teor de isoflavonas agliconas em grãos de soja [Glycine max (L.) Merrill]. O estudo foi realizado com as cultivares de soja BR 36, FEPAGRO RS-10 e BRS 155, cultivadas em Londrina, em Capanema e em Palmas, PR, na safra 1999/2000, mediante tratamentos hidrotérmicos de 40, 50 e 60°C por 12 e 18 horas. As maiores concentrações de isoflavonas totais (280 mg/100 g) foram observadas nos grãos colhidos em Palmas, onde a temperatura média durante o enchimento de vagens foi mais baixa (19ºC). Em Londrina (23ºC), houve menor concentração de isoflavonas (140 mg/100 g). A cultivar BRS 155 apresentou o maior teor de isoflavonas totais em Palmas e em Londrina. Grãos não-tratados da BRS 155 apresentaram em média 4,0 mg/100 g de agliconas, as quais aumentaram para 52 mg/100 g, após os tratamentos hidrotérmicos. O tratamento a 50ºC por 12 horas foi mais efetivo no desenvolvimento de isoflavonas agliconas. A 60°C, houve redução das agliconas, decorrente da inativação das b-glicosidases. As formas malonil, que são termicamente instáveis, também foram reduzidas nas temperaturas mais altas.

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FANG, Gao, Peng ZHANG, Xiao-lan YE, Xia ZHU, Xin ZHAO, and Guo-rong FAN. "Electron spray ion trap mass spectrometry of isoflavones and isoflavone aglycones of Semen Sojae Praeparatum." Academic Journal of Second Military Medical University 33, no. 10 (2013): 1108–15. http://dx.doi.org/10.3724/sp.j.1008.2013.01108.

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Verkasalo, Pai K., Paul N. Appleby, Naomi E. Allen, Gwyneth Davey, Herman Adlercreutz, and Timothy J. Key. "Soya intake and plasma concentrations of daidzein and genistein: validity of dietary assessment among eighty British women (Oxford arm of the European Prospective Investigation into Cancer and Nutrition)." British Journal of Nutrition 86, no. 3 (2001): 415–21. http://dx.doi.org/10.1079/bjn2001424.

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Soya products contain high levels of the isoflavones genistein and daidzein, and their glucosides, and may lower the risk of cardiovascular disease, osteoporosis and cancer. The present cross-sectional study investigated plasma concentrations of daidzein and genistein and their correlations with dietary soya consumption in four groups of twenty premenopausal British women. The women were selected from the Oxford arm of the European Prospective Investigation into Cancer and Nutrition using data from food-frequency questionnaires (FFQ) to guarantee a wide variation in soya consumption, and to investigate the utility of the question related to soya milk consumption compared with the utility of the question related to other soya foods. Dietary intakes of isoflavones were additionally assessed by 7 d food diaries. Plasma concentrations of daidzein and genistein were measured by time-resolved fluoroimmunoassay. Geometric mean plasma concentrations (nmol/l) were for the four groups, which were based on increasing soya intake, 4·9, 8·4, 39·2 and 132 for daidzein and 14·3, 16·5, 119 and 378 for genistein. The Spearman correlation coefficients for plasma isoflavone concentrations with estimated dietary intakes were between 0·66 and 0·80 for the diary-based estimates and between 0·24 and 0·74 for the FFQ-based estimates. The correlations for soya milk intakes were clearly higher than the correlations for intakes of other soya foods. We conclude that both the food diary and the FFQ estimate dietary soya isoflavone intakes sufficiently well to use them in epidemiological studies, and that plasma concentrations of daidzein and genistein in Western women who consumed soya products as a part of their regular diet were close to those in Asian populations.

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Lui, Maria Cristina Y., Cláudio L. Aguiar, Severino M. de Alencar, Adilma Regina P. Scamparini, and Yong K. Park. "Isoflavonas em isolados e concentrados protéicos de soja." Ciência e Tecnologia de Alimentos 23 (December 2003): 206–12. http://dx.doi.org/10.1590/s0101-20612003000400038.

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Hua, Chenlei, Yonglin Wang, Xiaobo Zheng та ін. "A Phytophthora sojae G-Protein α Subunit Is Involved in Chemotaxis to Soybean Isoflavones". Eukaryotic Cell 7, № 12 (2008): 2133–40. http://dx.doi.org/10.1128/ec.00286-08.

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ABSTRACT For the soybean pathogen Phytophthora sojae, chemotaxis of zoospores to isoflavones is believed to be critical for recognition of the host and for initiating infection. However, the molecular mechanisms underlying this chemotaxis are largely unknown. To investigate the role of G-protein and calcium signaling in chemotaxis, we analyzed the expression of several genes known to be involved in these pathways and selected one that was specifically expressed in sporangia and zoospores but not in mycelium. This gene, named PsGPA1, is a single-copy gene in P. sojae and encodes a G-protein α subunit that shares 96% identity in amino acid sequence with that of Phytophthora infestans. To elucidate the function, expression of PsGPA1 was silenced by introducing antisense constructs into P. sojae. PsGPA1 silencing did not disturb hyphal growth or sporulation but severely affected zoospore behavior, including chemotaxis to the soybean isoflavone daidzein. Zoospore encystment and cyst germination were also altered, resulting in the inability of the PsGPA1-silenced mutants to infect soybean. In addition, the expressions of a calmodulin gene, PsCAM1, and two calcium- and calmodulin-dependent protein kinase genes, PsCMK3 and PsCMK4, were increased in the mutant zoospores, suggesting that PsGPA1 negatively regulates the calcium signaling pathways that are likely involved in zoospore chemotaxis.

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Mendoza Meza, Dary Luz. "The effects of soybean isoflavones over the bone health of adult and children." Salud Uninorte 31, no. 1 (2015): 138–52. http://dx.doi.org/10.14482/sun.31.1.6087.

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Pérez-Rovira, Andrea, and Núria Mach. "Efecto del consumo de soja en relación con los síntomas de la menopausia." Revista Española de Nutrición Humana y Dietética 16, no. 2 (2012): 69. http://dx.doi.org/10.14306/renhyd.16.2.96.

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La menopausia se caracteriza por el cese de la función ovárica y la disminución hormonal de estrógenos. Estos cambios conllevan una serie de trastornos que pueden afectar a la vida de la mujer. La medicina, debido a la influencia de la industria farmacéutica, tiende a actuar de forma agresiva, y como consecuencia tenemos una población polimedicada. Los médicos suelen recetar tratamientos, como la terapia hormonal sustitutiva (THS), que ayuda a controlar estos síntomas. No obstante, recientemente varios estudios han demostrado efectos adversos asociados a la THS. Actualmente se conoce la influencia de la dieta en muchas de las enfermedades que afectan a la población de los países occidentales. Así, sla soja dietética y algunos suplementos de isoflavonas se han propuesto como alternativas para paliar los síntomas de la menopausia. Varios estudios indican que se puede utilizar las isoflavonas, de gran potencia estrogénica, como alternativa a la THS por su capacidad de reducir los síntomas menopáusicos. No obstante, el conocimiento sobre los efectos de la ingesta de isoflavonas en los síntomas de la menopausia es escaso y las publicaciones científicas recientes muestran resultados dispares. Para esclarecer esta información, el objetivo de esta revisión es describir algunos de los mecanismos mediante los cuales ejercen su acción las isoflavonas, y sus acciones beneficiosas, postulando que, como suplementos alimentarios, se podría utilizarlos como tratamiento complementario para algunos de los síntomas de la menopausia, lo que permitiría disminuir las dosis de THS.

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Chantre, Ph. "Isoflavones de soja et bouffées de chaleur." Phytothérapie 4, S1 (2006): hs4—hs7. http://dx.doi.org/10.1007/s10298-006-0127-0.

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Tsangalis, Dimitri, Gisela Wilcox, Nagendra P. Shah, and Lily Stojanovska. "Bioavailability of isoflavone phytoestrogens in postmenopausal women consuming soya milk fermented with probiotic bifidobacteria." British Journal of Nutrition 93, no. 6 (2005): 867–77. http://dx.doi.org/10.1079/bjn20041299.

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We investigated the effects of consuming an isoflavone aglycone-enriched soya milk containing viable bifidobacteria on urinary isoflavone excretion and percentage recovery. Sixteen postmenopausal women were randomly divided into two groups to consume either fermented or non-fermented soya milk. Each group participated in a double-blind, crossover study with three 14 d supplementation periods, separated by a 14 d washout. Subjects ingested three daily dosages of isoflavone via the soya milk and collected four 24 h pooled urine specimens per supplementation period. Soya milks were prepared with soya protein isolate and soya germ, followed by fermentation with bifidobacteria. Isoflavone levels were quantified using HPLC. Non-fermented soya milks at 20, 40 and 80 mg isoflavone/200 ml contained 10 %, 9 % and 7 % aglycone, respectively, with their fermented counterparts containing 69 %, 57 % and 36 % aglycone (P<0·001). A trend to a greater percentage urinary recovery of daidzein and glycitein was observed among women consuming fermented soya milk at a dosage of 40 mg isoflavone (P=0·13). A distinct linear dose response for the fermented soya milk group (R2=0·9993) compared with the non-fermented group (R2=0·8865) suggested less interindividual variation in isoflavone absorption. However, total urinary isoflavone excretion was similar for both groups (P>0·05), with urinary isoflavone recovery at approximately 31 %. Increasing the isoflavone dosage correlated positively with its urinary excretion, but urinary percentage recovery of isoflavone was inversely related to dosage level. Hence, a modest dosage ranging from 20 to 30 mg/d may provide the most bioavailable source of isoflavone, regardless of whether it is via an aglycone-rich fermented soya milk or a glucoside-rich soya milk.

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Maskarinec, Gertraud, Kirsten Watts, Jamie Kagihara, Sandra M. Hebshi, and Adrian A. Franke. "Urinary isoflavonoid excretion is similar after consuming soya milk and miso soup in Japanese-American women." British Journal of Nutrition 100, no. 2 (2008): 424–29. http://dx.doi.org/10.1017/s0007114508898686.

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Based on the hypothesis that isoflavones are absorbed more efficiently from fermented than from non-fermented soya foods, we compared the urinary isoflavonoid excretion (UIE) after intake of miso soup or soya milk. We recruited twenty-one women with Japanese ancestry who consumed standardized soya portions containing 48 mg isoflavones. On day 1, half the women consumed soya milk, the other half started with miso soup. On day 3, the subjects ate the other soya food and on day 5, they repeated the first food. Each participant collected a spot urine sample before and an overnight urine sample after soya food intake. All urine samples were analysed for daidzein, genistein and equol using LC–MS and were expressed as nmol/mg creatinine. We applied mixed models to evaluate the difference in UIE by food while including the baseline values and covariates. Relative to baseline, both groups experienced significantly higher UIE after consuming any of the soya foods. We observed no significant difference in UIE when soya milk was compared to miso soup (P = 0·87) among all women or in the seven equol producers (P = 0·88). Repeated intake of the same food on different days showed high reproducibility within subjects. These preliminary results indicate similar UIE after consuming a fermented soya food (miso) as compared to a non-fermented soya food (soya milk). Therefore, recommendations favouring fermented soya foods are not justified as long as the intestinal microflora is capable of hydrolysing the isoflavone glucosides from non-fermented soya foods.

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Hoey, Leane, Ian R. Rowland, Antony S. Lloyd, Don B. Clarke, and Helen Wiseman. "Influence of soya-based infant formula consumption on isoflavone and gut microflora metabolite concentrations in urine and on faecal microflora composition and metabolic activity in infants and children." British Journal of Nutrition 91, no. 4 (2004): 607–16. http://dx.doi.org/10.1079/bjn20031083.

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The urinary excretion of soya isoflavones and gut microflora metabolites was investigated in infants and children who had been fed soya-based infant formulas in early infancy. These infants and children were compared with cows'-milk formula-fed controls, to determine at what age gut microflora metabolism of daidzein to equol and/orO-desmethylangolensin (O-DMA) was established, and whether exposure to isoflavones in early infancy influences their metabolism at a later stage of development. Sixty infants and children (aged 4 months–7 years) participated in the study; thirty in each of the soya and control groups. There were four age groups. These were: 4–6 months (seven in the soya group and seven in the control group); 7–12 months (seven in the soya group and nine in the control group); 1–3 years (six in the soya group and eight in the control group); 3–7 years (ten in the soya group and six in the control group). Urine samples were collected to measure isoflavonoids by MS, and faecal samples were collected to measure gut-health-related bacterial composition, by fluorescentin situhybridisation with oligonucleotide probes, and metabolic activity. A soya challenge (typically a soya yoghurt alternative product containing 4·8g soya protein and on average 22mg total isoflavones) was given to control-group infants (>6 months) and children, and also to soya-group children that were no longer consuming soya, to determine their ability to produce equol and/orO-DMA. Urinary genistein, daidzein and glycitein were detected in all infants (4–6 months) fed soya-based infant formula;O-DMA was detected in 75% of infants but equol was detected in only 25%. In the controls (4–6 months), urinary isoflavonoids were very low or not detected. In the older age groups (7 months–7 years),O-DMA was found in the urine samples of 75% of the soya group and 50% of the controls, after the soya challenge. Equol excretion was detected in 19% of the soya-group infants and children, and in only 5% of the controls. However, in the oldest (3–7 years) children, the proportion excretingO-DMA and equol was similar in both groups. Faecal bacterial numbers forbifidobacteria(P<0·001),bacteroidesandclostridia(P<0·05) were significantly lower for the soya group compared with the control group. There appears to be no lasting effect of early-life isoflavone exposure on isoflavone metabolism.

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Daguer, Heitor, Luciano dos Santos Bersot, Sidney Pacheco, and Ronoel Luiz de Oliveira Godoy. "Detecção de soja pelo teor de isoflavonas em lombo injetado de suíno." Ciência Rural 40, no. 4 (2010): 990–93. http://dx.doi.org/10.1590/s0103-84782010005000046.

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No presente trabalho, a utilização de 1,5% de proteína isolada de soja em lombo de suíno foi detectada por meio do teor de isoflavonas, utilizando-se cromatografia líquida de alta eficiência. Elegeu-se o pico de genistina para quantificação, construindo-se uma curva-padrão com a proteína isolada de soja utilizada nas salmouras para injeção das carnes. A técnica revelou-se como uma alternativa rápida e eficaz para ser implantada no controle da utilização desse ingrediente em produtos cárneos.

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Ciabotti, Sueli, Maria de Fátima Píccolo Barcellos, José Marcos Gontijo Mandarino, and Adriana Gadioli Tarone. "Avaliações químicas e bioquímicas dos grãos, extratos e tofus de soja comum e de soja livre de Lipoxigenase." Ciência e Agrotecnologia 30, no. 5 (2006): 920–29. http://dx.doi.org/10.1590/s1413-70542006000500015.

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Com este trabalho, objetivou-se avaliar a composição química e aspectos bioquímicos de soja comum, comum branqueada e livre de lipoxigenases e o efeito do processamento dos seus respectivos extratos de soja e tofus. A composição centesimal das cultivares de soja comum e livre de lipoxigenase não se diferenciaram (p>0,05). Alterações na composição centesimal e de minerais dos extratos de soja e dos tofus foram atribuídas ao tratamento térmico (98 ºC/5 minutos) a que foi submetido o grão de soja comum e à etapa de maceração dos grãos, ficando evidente que algumas substâncias hidrossolúveis, foram migradas para a água de maceração dos grãos; o branqueamento na soja comum no início do processamento reduziu o teor de alguns minerais do extrato de soja (leite de soja), bem como no tofu. Ficou evidente as perdas de isoflavonas com o processamento na obtenção do tofu, na ordem de 38% no de SC, 31% no de SCB e 56% no de SLL. O processamento térmico utilizado para obtenção dos tofus foi suficiente para eliminar a atividade dos inibidores de tripsina em 79% do tofu de soja comum, 81% no tofu de soja branqueada e 82% nos tofus de soja livre de lipoxigenase.

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De Souza Rezer, Ana Paula, Barbara Cecconi Deon, Marcio Oliveira Hornes, Vanusa Granella, and Letícia Carine Rodrigues Mota. "DESENVOLVIMENTO E ACEITAÇÃO SENSORIAL DE “IOGURTE” DE SOJA ORGÂNICO E CONVENCIONAL." Revista Brasileira de Agrotecnologia 11, no. 2 (2021): 239–42. http://dx.doi.org/10.18378/rebagro.v12i2.8959.

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A soja é considerada uma das melhores alternativas para substituição das proteínas de origem animal. É importante fonte de fibras, oligossacarídeos com potencial prebiótico, como rafinose e estaquiose, vitaminas e minerais, antioxidantes naturais, isoflavonas e fosfolipídeos. O consumo da soja orgânica cresce juntamente com a tendência da sociedade de buscar hábitos de vida mais saudáveis. A soja orgânica é uma ótima alternativa para produção de leite de soja e derivados, como o iogurte, possibilitando o consumo deste produto por vegetarianos, veganos e intolerantes à lactose. Este trabalho teve como objetivo comparar iogurte de soja orgânico e convencional, analisando alguns parâmetros físico-químicos e sensorialmente através do teste de preferência e aceitação. O iogurte orgânico foi preparado com matéria-prima de origem orgânica (soja, açúcar e polpa de morango). Os resultados dos parâmetros físico-químicos para os dois produtos avaliados estão dentro dos limites para produtos fermentados. Não houve diferença significativa nos testes sensoriais de preferência. Os índices de aceitação para os atributos avaliados, nos dois iogurtes, ficaram com valores muito próximos, o que leva a concluir que o desenvolvimento de iogurte com soja orgânica ou convencional não altera os aspectos físico-químicos e sensoriais do produto obtido.

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Tobar-Tosse, Dora Enith, Renata Castoldi, Willame dos Santos Candido, Antonio Sergio Ferraudo, Hamilton Cesar de Oliveira Charlo, and Leila Trevisan Braz. "Caracterização de genótipos de soja-hortaliça por análise de componentes principais." Ciência Rural 45, no. 7 (2015): 1214–19. http://dx.doi.org/10.1590/0103-8478cr20140597.

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O presente estudo teve como objetivo caracterizar genótipos de soja-hortaliça, por meio de características agronômicas, nutricionais e antinutricionais, utilizando-se a Análise de Componentes Principais. O experimento foi conduzido em condições de campo no Setor de Olericultura e Plantas Aromático-Medicinais na UNESP-FCAV. O delineamento experimental foi em blocos casualizados com cinco genótipos e quatro repetições. Avaliaram-se as variáveis: número de vagens por planta, número de sementes por vagem, massa fresca das vagens por planta (g), massa fresca de 100 sementes (g), produtividade total estimada de grãos imaturos (kg ha-1), teor de umidade, proteínas, lipídeos, cinzas, carboidratos, isoflavonas e inibidores de tripsina Kunitz. As variáveis que contribuíram na discriminação dos genótipos no primeiro componente principal foram: peso total de vagens por planta, teor de proteínas, número de vagens por planta, peso de 100 sementes e teor de umidade, enquanto que aquelas que contribuíram no segundo componente principal foram: teor de cinzas, proteínas, número de vagens por planta e teor de lipídeos. Os genótipos JLM010, JLM024 e CNPSO1, destacaram-se por serem influenciados pelo peso total de vagens por planta, produtividade estimada, número de vagens por planta, teor de carboidratos, isoflavonas e de proteínas, sendo considerados genótipos de soja-hortaliça com potencial para serem utilizados em programas de melhoramento genético vegetal.

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Lacombe, Stéphanie, Vassilia Théodorou-Bayle, Philippe La Droitte, and Jean Dayde. "Les isoflavones du soja dans la filière aliment santé." Oléagineux, Corps gras, Lipides 7, no. 3 (2000): 286–96. http://dx.doi.org/10.1051/ocl.2000.0287.

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Chantre, P. "Étude d’innocuité évaluant les effets d’un extrait standardisé en isoflavones de soja (Phyto Soya®) sur le sein et l’endomètre." Phytothérapie 5, no. 4 (2007): 224–26. http://dx.doi.org/10.1007/s10298-007-0257-z.

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Barbosa, Ana Cristina Lopes, Neuza Mariko Aymoto Hassimotto, Franco Maria Lajolo, and Maria Inés Genovese. "Teores de isoflavonas e capacidade antioxidante da soja e produtos derivados." Ciência e Tecnologia de Alimentos 26, no. 4 (2006): 921–26. http://dx.doi.org/10.1590/s0101-20612006000400032.

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Pereira, Isabela Rosier Olimpio, Nágila Raquel Teixeira Damasceno, Edimar Cristiano Pereira, Leoberto Costa Tavares, and Dulcineia Saes Parra Abdalla. "Avaliação das concentrações plasmática e urinária de isoflavonas purificadas de soja." Revista Brasileira de Ciências Farmacêuticas 38, no. 3 (2002): 291–303. http://dx.doi.org/10.1590/s1516-93322002000300005.

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Chabla Mora, Rita Elizabeth, Peter Chedraui, Diana Pilar Correa Ruiz, Ruth Hipatia Sanchez Colina, Juan Eduardo Guzmán Garcés, and Zulman Elizabeth Recalde Enríquez. "Efecto positivo de la suplementación con isoflavonas derivadas de la soya sobre síntomas menopáusicos." Revista Colombiana Salud Libre 11, no. 1 (2016): 33–39. http://dx.doi.org/10.18041/1900-7841/rcslibre.2016v11n1.1620.

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Antecedente: En los últimos años han aumentado los tratamientos alternativos para el manejo de los síntomas de la menopausia, sobre todo en poblaciones de alto riesgo que tienen contraindicaciones para el uso de estrógenos. Objetivo: Evaluar el efecto de la suplementación con isoflavonas derivadas de la soya sobre síntomas climatéricos en mujeres postmenopáusicas. Método: Sesenta y seis mujeres postmenopáusicas entre 40 y 65 años de edad participaron en este estudio para recibir 50 mg/día de isoflavonas derivadas de soya durante 3 meses. Se evaluaron los síntomas de la menopausia al inicio del estudio y a los 45 y 90 días mediante la Escala de Puntuación de la Menopausia (MRS: Menopause Rating Scale). Resultados: La suplementación con isoflavonas derivadas de la soya tuvo un efecto positivo sobre síntomas de la menopausia. Así, los puntaje totales de la MRS disminuyeron significativamente de 23.0±8.7 (al basal) a 12.8±7 y 4.3±4.5 (45 y 90 días, respectivamente, ambos p<0.05). Se observó la misma tendencia para los puntajes de las sub-escalas del MRS (somática, psicológica y urogenital) y de cada uno de los síntomas componentes de las subescalas. Conclusión: En esta muestra de mujeres postmenopáusicas, la suplementación con isoflavonas derivadas de la soya ejerció un efecto positivo sobre los síntomas de la menopausia.

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Caëtano, Bertrand, Ludovic Le Corre, Nassera Chalabi, Laetitia Delort, Yves-Jean Bignon, and Dominique J. Bernard-Gallon. "Soya phytonutrients act on a panel of genes implicated with BRCA1and BRCA2 oncosuppressors in human breast cell lines." British Journal of Nutrition 95, no. 2 (2006): 406–13. http://dx.doi.org/10.1079/bjn20051640.

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Breast cancer is the most common cancer in women and a significant cause of death. Mutations of the oncosuppressor genes BRCA1 and BRCA2 are associated with a hereditary risk of breast cancer, and dysregulation of their expression has been observed in sporadic cases. Soya isoflavones have been shown to inhibit breast cancer in studies in vitro, but associations between the consumption of isoflavone-containing foods and breast cancer risk have varied in epidemiological studies. Soya is a unique source of the phytoestrogens daidzein (4′,7-dihydroxyisoflavone) and genistein (4′,5,7-trihydroxyisoflavone), two molecules that are able to inhibit the proliferation of human breast cancer cells in vitro. The aim of the present study was to determine the effects of genistein (5μg/ml) and daidzein (20μg/ml) on transcription in three human breast cell lines (one dystrophic, MCF10a, and two malignant, MCF-7 and MDA-MB-231) after 72h treatment. The different genes involved in the BRCA1 and BRCA2 pathways (GADD45A, BARD1, JUN, BAX, RB1, ERα, ERβ, BAP1, TNFα, p53, p21Waf1/Cip1, p300, RAD51, pS2, Ki-67) were quantified by real-time quantitative RT-PCR, using the TaqMan method and an ABI Prism 7700 Sequence Detector (Applied Biosystems). We observed that, in response to treatment, many of these genes were overexpressed in the breast cancer cell lines (MCF-7 and MDA-MB-231) but not in the dystrophic cell line (MCF10a).

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Oliveira, Marcelo Alvares de, Mercedes Concórdia Carrão-Panizzi, José Marcos Gontijo Mandarino, and Rodrigo Santos Leite. "Produção de brotos de soja utilizando a cultivar BRS 216: caracterização físico-química e teste de aceitabilidade." Brazilian Journal of Food Technology 16, no. 1 (2013): 34–41. http://dx.doi.org/10.1590/s1981-67232013005000009.

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O presente trabalho teve por objetivo avaliar os parâmetros físico-químicos e os processos para a produção de brotos de soja a partir de sementes da cultivar BRS 216, bem como sua composição química e aceitabilidade. Foram avaliados o comprimento e o peso dos brotos viáveis, a composição centesimal e os teores de isoflavonas e de inibidor de tripsina. O desenho experimental foi ao acaso com três repetições e os tratamentos foram avaliados num esquema fatorial 3 × 3: três frequências de irrigação (a cada quatro, oito e 12 horas) e três períodos de crescimento (cinco, seis e sete dias). O teste de aceitabilidade dos brotos de soja foi realizado utilizando-se a escala hedônica estruturada de nove pontos, avaliando-se cor, aparência, odor, textura, sabor e avaliação global, além da intenção de compra. A frequência de irrigação com intervalos de quatro horas e o período de sete dias de crescimento foram ideais para produção dos brotos de soja, favorecendo maior produtividade, teores mais elevados de proteínas e menores teores de inibidor de tripsina. O índice de aceitabilidade dos brotos de soja foi superior a 70 em todas as características avaliadas, com exceção do odor.

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Vergne, S., and P. Sauvant. "Les isoflavones de soja dans le traitement de la ménopause." Phytothérapie 4, no. 4 (2006): 172–80. http://dx.doi.org/10.1007/s10298-006-0178-2.

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Aguiar, C. L., C. N. Suzuki, J. F. Paredes-Guzmán, S. M. Alencar та Y. K. Park. "TRANSFORMACIÓN DE LAS β-GLICOSIL ISOFLAVONAS POR FERMENTACIÓN SEMI-SÓLIDA DE HARINA DE SOJA CONAspergillus oryzaeTRANSFORMATION OF β-GLUCOSIDE ISOFLAVONES ON SOLID-STATE FERMENTATION OF THE SOY FLOUR WITHAspergillus oryzaeTRANSFORMACIÓN DAS β-GLICOSIL-ISOFLAVONAS POR FERMENTACIÓN SEMI-SÓLIDA DE FARIÑA DE SOIA CONAspergillus oryzae". Ciencia y Tecnologia Alimentaria 4, № 2 (2003): 115–21. http://dx.doi.org/10.1080/11358120309487752.

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TSUKAMOTO, Chigen, Muhammad Amjad NAWAZ, Ayaka KUROSAKA, et al. "Isoflavone profile diversity in Korean wild soybeans ( Glycine soja Sieb. & Zucc.)." TURKISH JOURNAL OF AGRICULTURE AND FORESTRY 42, no. 4 (2018): 248–61. http://dx.doi.org/10.3906/tar-1801-95.

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Genovese, Maria Inés, Márcia da Silva Pinto, Ana Cristina Lopes Barbosa, and Franco Maria Lajolo. "Avaliação do teor de isoflavonas de "suplementos nutricionais à base de soja"." Revista Brasileira de Ciências Farmacêuticas 39, no. 2 (2003): 159–67. http://dx.doi.org/10.1590/s1516-93322003000200006.

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Rotondo, Serenella, Katarzyna Krauze-Brzósko, Stefano Manarini, et al. "Inhibition by soya isoflavones of human polymorphonuclear leukocyte function: possible relevance for the beneficial effects of soya intake." British Journal of Nutrition 99, no. 2 (2008): 240–47. http://dx.doi.org/10.1017/s0007114507797052.

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Lower CVD incidence is reported in Asian populations consuming soya-containing food. As polymorphonuclear leukocytes (PMN) are involved in the risk of CVD, we investigated the modulatory effect of soya isoflavones on several PMN functions and their molecular mechanismsin vitro. PMN, isolated from blood from healthy subjects, were tested upon activation with 1 μm- n-formyl-methyl-leucyl-phenylalanine (fMLP) for superoxide anion production (ferric cytochrome c reduction) and released elastase (chromogenic test). PMN homotypic aggregates stimulated by fMLP or P-selectin in dynamic conditions were detected by optical microscopy. PMN, mixed with thrombin-activated, washed platelets, formed cell aggregates, measured by flow cytometry. Phosphorylation of Pyk2, a focal adhesion kinase, was studied by immunoprecipitation and immunoblotting with specific antibodies. Genistein, daidzein and equol inhibited superoxide anion production (IC500·25 (sem0·1), 21·0 (sem4·2) and 13·0 (sem2·8) μm, respectively); the release of elastase was prevented by genistein (IC5063 (sem17) μm). PMN homotypic aggregates, stimulated by fMLP, were significantly reduced (24 (sem12) and 51 (sem14) % of control) by 100 μmgenistein and equol. P-selectin-induced aggregates were reduced to 19 (sem6), 44 (sem10) and 28 (sem9) % of control by 100 μmgenistein, daidzein and equol, respectively. Genistein, daidzein and equol also significantly reduced mixed platelet-PMN aggregates (IC504·0 (sem0·9), 57 (sem6) and 66 (sem23) μm, respectively). In PMN challenged by fMLP or P-selectin, activation of Pyk2 was prevented by isoflavones. The cardioprotective effect of soya-containing food might be linked to reduction of PMN activation and PMN-platelet interaction, novel targets for the biological effects of soya isoflavones.

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Clapauch, Ruth, Ricardo M. R. Meirelles, Maria Amélia S. G. Julião, et al. "Fitoestrogênios: posicionamento do Departamento de Endocrinologia Feminina da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)." Arquivos Brasileiros de Endocrinologia & Metabologia 46, no. 6 (2002): 679–95. http://dx.doi.org/10.1590/s0004-27302002000600013.

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Para avaliar a utilidade dos fitoestrogênios (FE) na terapia de reposição hormonal da menopausa (TRHM), o Departamento de Endocrinologia Feminina da SBEM reuniu um grupo de especialistas para fazer uma revisão bibliográfica e selecionar trabalhos nos quais a metodologia adotada demonstrasse rigor científico. Os FE têm ações estrogênicas e antiestrogênicas, predominantemente sobre os receptores de estrogênios (E) beta, com potência estrogênica muito inferior à do estradiol. O conteúdo de FE nas suas fontes vegetais é variável, dependendo da forma de cultivo, safra, armazenamento e industrialização. Também a conversão dos precursores em fitormônios ativos no organismo humano tem grande variabilidade individual. A maior parte das pesquisas com FE é realizada in vitro ou com animais de laboratório, nem sempre podendo ser extrapoladas para humanos. Com relação à síndrome do climatério, alguns estudos sugerem discreta melhora dos fogachos, sem modificação do ressecamento vaginal ou das alterações do humor. No metabolismo lipídico, alimentação rica em soja, mas não isoflavonas isoladamente, promove redução do colesterol total, do LDL-col e dos triglicerídeos, mas não elevam o HDL-col, como os E, e podem causar aumento da lipoproteína (a), que os E contribuem para diminuir. Embora alguns estudos de curta duração sugiram aumento da densidade mineral óssea com uso de isoflavonas, não há demonstração de redução de fraturas. Conclui-se que não há evidências convincentes que justifiquem o uso de FE ou alimentação rica em soja como alternativa para a TRHM.

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