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Journal articles on the topic 'Isoindolo[1'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Nakao, Michiyasu, Nanako Nishikiori, Akihito Nakamura, et al. "Synthesis of Sterically Protected Isoindoles from ortho-Phthalaldehyde." SynOpen 02, no. 01 (2018): 0050–57. http://dx.doi.org/10.1055/s-0036-1591932.

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o-Phthalaldehyde (OPA) reacts with O-protected tris(hydroxyalkyl)aminomethanes in the presence of 1-propanethiol to afford a novel class of stable isoindoles. Steric protection provided by the bulkiness of C 3-symmetric primary amines derived from tris(hydroxymethyl)aminomethane could be significant for the stabilization of 1-alkylthio-2-alkyl-substituted isoindoles derived from OPA. A plausible reaction mechanism is proposed to explain the formation of the isoindole and an isoindolin-1-one by-product.

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2

Rodríguez, Ricaurte, Omar León, Felipe Quiroga, and Jonnathan Cifuentes. "N-{2-[(3-Oxo-1,3-dihydro-2-benzofuran-1-yl)acetyl]phenyl}acetamide." Molbank 2021, no. 3 (2021): M1244. http://dx.doi.org/10.3390/m1244.

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With the aim of obtaining different derivatives belonging to the isoindolo[2,1-a]quinoline family, we have synthesized a novel N-{2-[(3-oxo-1,3-dihydro-2-benzofuran-1-yl)acetyl]phenyl}acetamide derivative by a Claisen–Smichdt-type condensation reaction in 75% yield.

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3

Leznoff, Clifford C., Shafrira Greenberg, Ben Khouw, and A. B. P. Lever. "The syntheses of mono- and disubstituted phthalocyanines using a dithioimide." Canadian Journal of Chemistry 65, no. 8 (1987): 1705–13. http://dx.doi.org/10.1139/v87-285.

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Hydrolysis of 5-neopentoxy-1,3-diiminoisoindoline gave 5-neopentoxy-1H-isoindole-1,3(2H)-dione (4-neopentoxyphthalimide), which, on treatment with Lawesson's reagent, yielded the thiophthalimides, 5-neopentoxy-1H-isoindole-1,3(2H)-dithione, 2,3-dihydro-6-neopentoxy-3-thioxo-1H-isoindol-1-one, and 2,3-dihydro-5-neopentoxy-3-thioxo-1H-isoindol-1-one. Attempted S-alkylations of the thiophthalimides resulted in the formation of β-isoindigos and N-alkylation products. In a new phthalocyanine synthesis crossed condensations of 1,3-diiminoisoindoline with 5-neopentoxy-1H-isoindole-1,3(2H)-dithione yi

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4

Odabasoglu, M., and O. Buyukgungor. "Structure of dihydro-isoindolo benzoxazine-11-one and dibromo-cyclopenta[a]naphthalene-1-one." Acta Crystallographica Section A Foundations of Crystallography 64, a1 (2008): C385. http://dx.doi.org/10.1107/s0108767308087692.

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5

Kraus, George A., and Hakwon Kim. "The Synthesis of Isoindolo[2, 1-a]indoles via Both Radical and Organopalladium Strategies." Synthetic Communications 23, no. 1 (1993): 55–64. http://dx.doi.org/10.1080/00397919308020401.

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6

Kim, Hyoung Shik, Yun Mi Chung, Young Ja Park та Jae Nyoung Kim. "ChemInform Abstract: Reinvestigation for the Synthesis of 1,2-Isoindolo-1(2H)-3,4-tetrahydro-β-carboline." ChemInform 31, № 44 (2000): no. http://dx.doi.org/10.1002/chin.200044153.

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7

Rosevear, J., and JFK Wilshire. "A Comparison of the Reactions of Some Ethyl N-Arylcarbamates With Those of the Corresponding Acetanilides. II. Amidomethylation With N-Hydroxy-methylphthalimide." Australian Journal of Chemistry 43, no. 2 (1990): 339. http://dx.doi.org/10.1071/ch9900339.

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The reactions of some ethyl N- arylcarbamates and of the corresponding acetanilides towards 1 equiv. of N-hydroxymethylphthalimide in concentrated sulfuric acid at 50° have been compared with one another. In the case of certain para-substituted compounds, amidomethylation occurs more readily ortho to the carbamate group than to the N-acetyl group. The diagnostic use of (D6)benzene as a 1H n.m.r. solvent, particularly for the structural elucidation of the ortho-( phthalimidomethyl )- phenylcarbamates and -acetanilides, is reported. Acidic treatment of the ortho -( phthalimidomethyl ) phenylcarb

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8

Tkachuk, V., T. Lyubchuk, T. Tkachuk, and O. Hordiyenko. "A DEVELOPMENT OF AN EFFECTIVE METHOD FOR THE SYNTHESIS OF 2-(5-OXO-4,5-DIHYDRO-1,2,4-OXADIAZOL-3-YL)BENZOIC ACID." Bulletin of Taras Shevchenko National University of Kyiv. Chemistry, no. 1 (57) (2020): 51–54. http://dx.doi.org/10.17721/1728-2209.2020.1(57).13.

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2-(5-Oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzoic acid was synthesized using a new effective method – thermal heterocyclization of 3-(hydroxyimino)isoindolin-1-one, which occurs as a result of its interaction with 1,1'-carbonyldiimidazole (CDI) and subsequent base-promoted cycleopening of the obtained intermediate 3H,5H-[1,2,4]oxadiazolo[3,4-a]isoindole-3,5-dione. Direct cyclization of 3-(hydroxyimino)isoindolin-1-one by the reaction with diethyl carbonate in the presence of sodium ethylate in ethanol at room temperature and under heating was unsuccessful. The same result was observed when usi

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9

Boltukhina, E. V., F. I. Zubkov, and A. V. Varlamov. "Methods for the construction of [1,2]isoindolo-condensed benzazepines, benzazocines, quinolines, and isoquinolines. 1. Isoindolobenzazepines, isoindolobenzazocines. (Review)." Chemistry of Heterocyclic Compounds 42, no. 7 (2006): 831–57. http://dx.doi.org/10.1007/s10593-006-0169-0.

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10

PIGEON, P., and B. DECROIX. "ChemInform Abstract: Tetracyclic Systems: Synthesis of Isoindolo(1,2-b)thieno(2,3(3,2 or 3, 4)-e)(1,3)thiazocines and Isoindolo(2,1-a)thieno(2,3(3,2 or 3,4)-f)(1, 4) and (1,5)diazocines." ChemInform 28, no. 37 (2010): no. http://dx.doi.org/10.1002/chin.199737190.

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11

Yegorova, Tatyana, Bogdan Barnych, and Zoia Voitenko. "Reaction of pyrido[2,1-a]isoindole with 1,4-naphtoquinone and study of the product by spectroscopic methods." French-Ukrainian Journal of Chemistry 4, no. 2 (2016): 33–39. http://dx.doi.org/10.17721/fujcv4i2p33-39.

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Key role of the electronic structure of condensed isoindols in the way of the rearrangement was shown. Influence of the dienophile manifests in the requirement of the cyclic form of the dienophile itself. In the reaction of pyrido[2,1-a]isoindole with naphtoquinone rearrangement product of the first type was obtained and its structure was proven by spectral methods. Spectral criteria for the rearranged adducts of the first type for the pyrido[2,1-a]isoindole in the 13C NMR spectra were established. Products of reactions with naphthoquinone, 4-fluoro-, 2,5-difluorophenylmaleimides were isolated

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12

Otani, Junji, Hiroshi Yamamoto, Makoto Fukuda, and Kunihiko Kodama. "Time-resolved study of intramolecular charge transfer fluorescence in 1,2,3,4-tetrachloro-11H-isoindolo-[2, 1-a]-benzimidazol-11-one." Journal of Luminescence 104, no. 4 (2003): 273–81. http://dx.doi.org/10.1016/s0022-2313(03)00081-4.

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13

Fodor, Kinga Judit, Dániel Hutai, Tamás Jernei та ін. "Novel Polycondensed Partly Saturated β-Carbolines Including Ferrocene Derivatives: Synthesis, DFT-Supported Structural Analysis, Mechanism of Some Diastereoselective Transformations and a Preliminary Study of their In Vitro Antiproliferative Effects". Molecules 25, № 7 (2020): 1599. http://dx.doi.org/10.3390/molecules25071599.

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Use of a Pictet-Spengler reaction of tryptamine and l-tryptophan methyl ester and subsequent reduction of the nitro group followed by further cyclocondensation with aryl aldehydes and formyl–substituted carboxylic acids, including ferrocene-based components, furnished a series of diastereomeric 6-aryl-substituted 5,6,8,9,14,14b-hexahydroindolo[2′,3′:3,4]pyrido[1-c]-quinazolines and 5,5b,17,18-tetrahydroindolo[2′,3′:3,4]pyrido[1,2-c]isoindolo[2,1-a]quinazolin-11-(15bH)-ones with the elements of central-, planar and conformational chirality. The relative configuration and the conformations of th

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14

Giofrè, Salvatore V., Santa Cirmi, Raffaella Mancuso, et al. "Synthesis of spiro[isoindole-1,5’-isoxazolidin]-3(2H)-ones as potential inhibitors of the MDM2-p53 interaction." Beilstein Journal of Organic Chemistry 12 (December 20, 2016): 2793–807. http://dx.doi.org/10.3762/bjoc.12.278.

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A series of spiro[isoindole-1,5-isoxazolidin]-3(2H)-ones has been synthesized by 1,3-dipolar cycloaddition of N-benzylnitrone with isoindolin-3-methylene-1-ones. The regio- and stereoselectivity of the process have been rationalized by computational methods. The obtained compounds show cytotoxic properties and antiproliferative activity in the range of 9–22 μM. Biological tests suggest that the antitumor activity could be linked to the inhibition of the protein–protein p53-MDM2 interaction. Docking measurements support the biological data.

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15

Schubert-Zsilavecz, Manfred, Astrid Michelitsch, Werner Likussar, and Dagmar Gusterhuber. "Synthese und polarographisches Verhalten neuer Isoindole. – 1-Aryl- und 1-Styryl-2H-isoindol-4,7-dione." Liebigs Annalen der Chemie 1993, no. 2 (1993): 147–51. http://dx.doi.org/10.1002/jlac.199319930127.

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16

Van, Hue Thi My, and Won-Jea Cho. "Structural modification of 3-arylisoquinolines to isoindolo[2,1-b]isoquinolinones for the development of novel topoisomerase 1 inhibitors with molecular docking study." Bioorganic & Medicinal Chemistry Letters 19, no. 9 (2009): 2551–54. http://dx.doi.org/10.1016/j.bmcl.2009.03.042.

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17

Zhang, Wei, Yuehua Zhou, and Lingfeng Qian. "One-Pot Synthesis of Isoindolo[2,1-a]quinolin-11-ones by Cyclocondensation of 3-Hydroxy-2-arylisoindol-1-ones with 1,3-Dicarbonyls." Synlett 2009, no. 05 (2009): 843–47. http://dx.doi.org/10.1055/s-0028-1087955.

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18

Bodhak, Chandan, Subhenjit Hazra, and Animesh Pramanik. "Graphene Oxide: An Efficient Carbocatalyst for the Facile Synthesis of Isoindolo[2, 1‐ a ]quinazoline‐5,11‐diones via Domino Condensation under Solvent‐Free Conditions." ChemistrySelect 3, no. 27 (2018): 7707–12. http://dx.doi.org/10.1002/slct.201801322.

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19

Zubkov, Fedor I., Ekaterina V. Boltukhina, Eugenia V. Nikitina, and Alexey V. Varlamov. "Novel Approach to Isoindolo[2,1-a]quinolines: Synthesis of 1- and 3-Halo-Substituted 11-Oxo-5,6,6a,11-tetrahydroisoindolo[2,1-a]quinoline-10-carboxylic Acids." Synthesis 2005, no. 11 (2005): 1859–75. http://dx.doi.org/10.1055/s-2005-869948.

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20

Makhmud, Mokhamed Abdel-Moneim, V. K. Vasilin, and G. D. Krapivin. "Isoindolo[1′,2′:2,3]pyrido[3″,2″:4′,5′]thieno[3′,2′: 4,5]-pyrimido[1,6-a]benzimidazol-8(12bH)-one. A novel polycondensed heterocyclic system." Chemistry of Heterocyclic Compounds 42, no. 11 (2006): 1501–2. http://dx.doi.org/10.1007/s10593-006-0275-z.

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21

Mejai, Amani, Nambinina V. Rakotoarivelo, Ennaji Najahi, et al. "The Clitocybins and 2-Substituted-Isoindolin-1-Ones: Synthesis and in Vitro Antimycobacterial Activities." JOURNAL OF ADVANCES IN CHEMISTRY 16 (October 28, 2019): 5387–94. http://dx.doi.org/10.24297/jac.v16i0.8476.

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Despite strong indications of antimycobacterial activities for clitocybins reported since 1945, no reports linking chemical structure and activity have been reported in the literature since then. In this study, we synthesized some clitocybin derivatives (also called 2-substituted-isoindolinones), and tested their activities and carried out some chemical derivations. Isoindolinones were prepared from methyl 2-formyl-3,5-dimethoxybenzoate and various primary aromatic amines. Compounds were evaluated for in vitro activity against Mycobacterium tuberculosis H37Rv, as well as for cytotoxicity (CC50

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22

Gromachevskaya, E. V., A. S. Pilipenko, A. V. Butin, V. E. Zavodnik, and G. D. Krapivin. "Investigations in the field of benzoxa- zines. 15*. Tandem heterocyclizations with the participion of 2-formylbenzoic acid. The synthesis of isoindolo[1,2-b][1, 3]- and -[2,1-a][1, 3]benzoxazinones." Chemistry of Heterocyclic Compounds 46, no. 1 (2010): 106–16. http://dx.doi.org/10.1007/s10593-010-0476-3.

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23

Zubkov, Fedor I., Ekaterina V. Boltukhina, Konstantin F. Turchin та Alexey V. Varlamov. "An efficient approach to isoindolo[2,1-b][2]benzazepines via intramolecular [4+2] cycloaddition of maleic anhydride to 4-α-furyl-4-N-benzylaminobut-1-enes". Tetrahedron 60, № 38 (2004): 8455–63. http://dx.doi.org/10.1016/j.tet.2004.07.008.

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24

Kreher, Richard P., Hans Hennige, Frank Jelitto, and Johannes Preut. "Untersuchungen zur Chemie von Isoindolen und Isoindoleninen, XXXV [1]. 1-Alkoxy-2-alkyl-2 H-isoindole — o-chinoide Hetarene mit unsymmetrischer Struktur / Studies on the Chemistry of Isoindoles and Isoindolenines, XXXV [1]. 1-Alkoxy-2-alkyl-2H-isoindoles — o-Quinonoid Hetarenes with Unsymmetric Structure." Zeitschrift für Naturforschung B 44, no. 9 (1989): 1132–48. http://dx.doi.org/10.1515/znb-1989-0923.

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3-Alkoxy-2-methyl-1 H-isoindolium salts have been prepared either via regioselective O-alkylation of the corresponding 2-alkyl-isoindoline-1-ones or via regioselective N-alkylation of 3-alkoxy-1 H-isoindoles with trialkyloxonium tetrafluoroborates or with alkyl trifluoromethanesulfonates. Deprotonation of these stable precursors leads to the generation of reactive 1-alkoxy-2-alkyl-2H-isoindoles in solution. Reactions with CC-dienophiles (N-substituted maleic imides) give rise to the formation of 1 : 2-adducts. The two step reaction comprises Michael-addition and Diels-Alderaddition; the isolat

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25

SCHUBERT-ZSILAVECZ, M., A. MICHELITSCH, W. LIKUSSAR, and D. GUSTERHUBER. "ChemInform Abstract: Synthesis and Polarographic Behavior of Novel Isoindoles. 1-Aryl- and 1-Styryl-2H-isoindole-4,7-diones." ChemInform 24, no. 24 (2010): no. http://dx.doi.org/10.1002/chin.199324161.

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26

Zubkov, Fedor I., Ekaterina V. Boltukhina, Konstantin F. Turchin, Roman S. Borisov, and Alexey V. Varlamov. "New synthetic approach to substituted isoindolo[2,1-a]quinoline carboxylic acids via intramolecular Diels–Alder reaction of 4-(N-furyl-2)-4-arylaminobutenes-1 with maleic anhydride." Tetrahedron 61, no. 16 (2005): 4099–113. http://dx.doi.org/10.1016/j.tet.2005.02.017.

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27

Clemens, Andrea, and Richard P. Kreher. "Untersuchungen zur Chemie von Isoindolen und Isoindoleninen, XXXX 1-Methoxy-2-methyl-3-aryl-2 H-isoindole: Generierung - Charakterisierung - Isolierung / Studies on the Chemistry of Isoindoles and Isoindolenines, XXXX 1-Methoxy-2-methyl-3-aryl-2 H-isoindoles: Generation — Characterization — Isolation." Zeitschrift für Naturforschung B 48, no. 9 (1993): 1257–69. http://dx.doi.org/10.1515/znb-1993-0915.

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1-Methoxy-2-methyl-3-aryl-2 H-isoindoles are accessible via an efficient and economical manner starting from 3-aryl-isoindoline-1-ones; the four step synthesis makes use of the ambivalent reactivity of the cyclic carbonamide group. The regiospecific O-methylation and NH-deprotonation is consecuted by the regiospecific N-methylation of the 3-methoxy-1-aryl-1H-isoindoles and the chemoselective CH-deprotonation. The electronic stabilization of these o-quinonoid hetarenes by an aryl group in 3-position is essential for isolation.

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28

FUJINO, Hiroyuki, Hideyuki YOSHIDA, Hitoshi NOHTA, and Masatoshi YAMAGUCHI. "HPLC Determination of Acetaminophen in Saliva Based on Precolumn Fluorescence Derivatization with 12-(3,5-Dichloro-2,4,6-triazinyl)-benzo[d]benzo[1',2'-6,5]isoindolo[1,2-b][1,3]thiazolidine." Analytical Sciences 21, no. 9 (2005): 1121–24. http://dx.doi.org/10.2116/analsci.21.1121.

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29

Wang, Yinan, Hui Chen, Ruilong Sheng, et al. "Synthesis and Bioactivities of Marine Pyran-Isoindolone Derivatives as Potential Antithrombotic Agents." Marine Drugs 19, no. 4 (2021): 218. http://dx.doi.org/10.3390/md19040218.

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2,5-Bis-[8-(4,8-dimethyl-nona-3,7-dienyl)-5,7-dihydroxy-8-methyl-3-keto-1,2,7,8-teraahydro-6H-pyran[a]isoindol-2-yl]-pentanoic acid (FGFC1) is a marine pyran-isoindolone derivative isolated from a rare marine microorganism Stachybotrys longispora FG216, which showed moderate antithrombotic(fibrinolytic) activity. To further enhance its antithrombotic effect, a series of new FGFC1 derivatives (F1–F7) were synthesized via chemical modification at C-2 and C-2′ phenol groups moieties and C-1″ carboxyl group. Their fibrinolytic activities in vitro were evaluated. Among the derivatives, F1–F4 and F6

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30

Louvet, Philippe, FrançOis Thomasson, and Cuong Luu-Duc. "Synthesis and spectroscopic characterizations of both 4b,5-dihydro-4b-methyl-11H-isoindolo[2,1-a]benzimidazol-11-ones and 2,3,3a,4-tetrahydro-3a-methyl-1H-pyrrolo[1,2-a]benzimidazol-1-ones." Journal of Heterocyclic Chemistry 31, no. 1 (1994): 39–44. http://dx.doi.org/10.1002/jhet.5570310106.

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31

Nurmaganbetov, Zh S., O. A. Nurkenov, S. D. Fazylov, et al. "Synthesis and Spatial Structure of 3-Phenylacrylic Acid Octahydroquinolizin-1-Ylmethyl Ester and 2-(Octahydroquinolizin-1-Ylmethyl)Isoindole-1,3-Dione." Eurasian Chemico-Technological Journal 26, no. 3 (2024): 175–83. http://dx.doi.org/10.18321/ectj1641.

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The reactions of lupinine alkaloid and its chlorine derivative with cinnamoyl chloride and 2-K-isoindole-1,3-dione were investigated to obtain 3-phenylacrylic acid octahydroquinolizin-1-ylmethyl ester and 2-(octahydroquinolizin-1-ylmethyl)isoindole-1,3-dione, respectively. The optimal conditions for carrying out the aforementioned reactions were determined, taking into account the nature of the solvent and medium. It was established that acylation of the molecule in a benzene medium, in the presence of trimethylamine, resulted in the formation of 3-phenylacrylic acid octahydroquinolizin-1-ylme

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32

Bhat, Mashooq A., Mohamed A. Al-Omar, Ahmed M. Naglah, and Abdullah Al-Dhfyan. "Biginelli Synthesis of Novel Dihydropyrimidinone Derivatives Containing Phthalimide Moiety." Journal of Chemistry 2020 (March 9, 2020): 1–5. http://dx.doi.org/10.1155/2020/4284628.

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A new series of novel Biginelli compounds, 5-benzoyl-substituted phenyl-3,4-dihydropyrimidin-2(1H)-one-1H-isoindole-1,3(2H)-dione (1−10), were synthesized from enaminone, 2-{4-[(2E)-3-(dimethylamino)prop-2-enoyl]phenyl}-1H-isoindole-1,3(2H)-dione (IV), which was synthesized by refluxing 2-(4-acetylphenyl)-1H-isoindole-1,3(2H)-dione (III), with dimethylformamide-dimethylacetal (DMF-DMA) without solvent for 12 h. The compound 2-(4-acetylphenyl)-1H-isoindole-1,3(2H)-dione (III) was obtained by reacting phthalic anhydride (I) with para-aminoacetophenone (II) in glacial acetic acid for 2 h. The dih

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33

Al-Shihry, Shar. "Synthesis of antifungal isoindole (5-methyl-isoxazole-3-yl)-[2-(5-methyl-isoxazol-3-yl)2,3-dihydro-isoindol-1-ylidene]amine." Molbank 2005, no. 6 (2005): M447. http://dx.doi.org/10.3390/m447.

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34

Kreher, Richard P., Udo Feldhoff, and Frank Jelitto. "Untersuchungen zur Chemie von Isoindolen und Isoindoleninen, XXXII [1] Elektrophile Substitutionsreaktionen von 2-Aryl-2H-isoindolen mit Trifluoressigsäureanhydrid / Studies on the Chemistry of Isoindoles and Isoindolenines, XXXII [1] Electrophilic Substitution Reactions of 2-Aryl-2H-isoindoles with Trifluoroacetic Anhydride." Zeitschrift für Naturforschung B 43, no. 10 (1988): 1332–40. http://dx.doi.org/10.1515/znb-1988-1020.

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The reaction of 2-aryl-2H-isoindoles with trifluoroacetic anhydride in pyridine leads to the formation of the corresponding 1-trifluoroacetyl-2-aryl-2H-isoindoles with acceptable yields. 1-Alkylthio-2-aryl-2H-isoindoles can be generated from 3-alkylthio-2-aryl-1 H-isoindolium-tri-fluoromethanesulfonates with pyridine and acylated in the same manner. Protonation occurs at 1-position and yields isolable 1H-isoindolium salts.

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35

Valente, E. J., S. B. Martin, and L. D. Sullivan. "Pseudoacids. II. 2-Acylbenzoic Acid Derivatives." Acta Crystallographica Section B Structural Science 54, no. 3 (1998): 264–76. http://dx.doi.org/10.1107/s0108768197012020.

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Structures of derivatives of cyclic o-acylbenzoic acids, including the chloride, endo- and exocyclic amides, esters and anhydrides, are examined. 3-Chloro-1(3H)-isobenzofuranone (1), orthorhombic, Pbca, a = 11.616 (5), b = 8.120 (3), c = 15.640 (9) Å; 3-methoxy-3-phenyl-1(3H)-isobenzofuranone (3), orthorhombic, P212121, a = 6.923 (2), b = 8.291 (4), c = 21.551 (8) Å; 3-hydroxy-3-phenyl-N-propyl-1(3H)-isoindolone (4), orthorhombic, P212121, a = 8.662 (4), b = 9.551 (7), c = 17.649 (14) Å; 3-(N-morpholino)-1(3H)-isobenzofuranone (5), triclinic, P1¯, a = 6.172 (4), b = 11.163 (7), c = 17.33 (2) Å

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36

LOUVET, P., F. THOMASSON, and LUU-DUC CUONG LUU-DUC CUONG. "ChemInform Abstract: Synthesis and Spectroscopic Characterizations of Both 4b,5-Dihydro-4b- methyl-11H-isoindolo(2,1-a)benzimidazol-11-ones and 2,3,3a,4- Tetrahydro-3a-methyl-1H-pyrrolo(1,2-a)benzimidazol-1-ones." ChemInform 26, no. 11 (2010): no. http://dx.doi.org/10.1002/chin.199511147.

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Tahira, Banu, Rajora Sonal, Khatri Dilip, and L. Talesara G. "Synthesis of some isoindole-1,3-dione and amino-oxyalkyl derivatives of benzimidazole." Journal of Indian Chemical Society Vol. 77, Jun 2000 (2000): 300–301. https://doi.org/10.5281/zenodo.5869883.

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Department of Chemistry, College of Science, Sukhadia University, Udaipur-313 001, India <em>Manuscript received 3 May 1999, revised 14 October 1999, accepted 23 February 2000</em> 2-(Bromoalkoxy)-1<em>H</em>-isoindole-1,3-diones are condensed with benzimidazole and its derivatives to give 2-[(benzimidazole-1-yl)-alkoxy]- 1<em>H</em>-isoindole-1,3-diones. Hydrolysis under acidic conditions gives the corresponding amino-oxy compounds.

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KHAN, Yamin M., Matthew WICTOME, Malcolm EAST, and Anthony G. J. LEE. "Labelling the Ca2+-ATPase of skeletal-muscle sarcoplasmic reticulum with the cross-linker o-phthalaldehyde." Biochemical Journal 317, no. 2 (1996): 433–37. http://dx.doi.org/10.1042/bj3170433.

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The Ca2+-ATPase in the sarcoplasmic reticulum of skeletal muscle reacts with o-phthalaldehyde (OPA) to form a fluorescent isoindole product. The stoichiometry of labelling of the ATPase is 9 nmol of isoindole/mg of ATPase, corresponding to a 1:1 molar ratio of isoindole:ATPase. There is no evidence for any intermolecular cross-linking. Isoindole formation is faster in the presence of methylamine, but the stoichiometry of labelling is unchanged, whereas in the presence of 2-mercaptoethanol the level of labelling is much higher. It is concluded that OPA reacts with a single Cys residue (defining

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Sonal, Rajora, Kumar Baregama Lalit, and L. Talesara G. "Synthesis of some arylalkoxyphthalimides." Journal of Indian Chemical Society Vol. 79, Feb 2002 (2002): 193–94. https://doi.org/10.5281/zenodo.5881846.

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Department of Chemistry, College of Science, M. L. Sukhadia University, Udaipur-313 001, India E-mail: gtalesara@yahoo.com Manuscript received 3 May 1999, revised 30 April 2001, accepted 5 June 2001 Some alkoxy-1<em>H</em>-isoindole-1,3(2<em>H</em>)-dione derivatives of phenothiazine and indole have been prepared by the action of i-(bromoalkoxy)- 1<em>H</em>-isoindole-1,3(2<em>H</em>)-dione with the corresponding heterocycles.

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40

Ghiasi, Reza, and Morteza Zaman Fashami. "Tautomeric transformations and reactivity of isoindole and sila-indole: A computational study." Journal of Theoretical and Computational Chemistry 13, no. 05 (2014): 1450041. http://dx.doi.org/10.1142/s0219633614500412.

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In this work, the tautomeric transformations and reactivity of isoindole and sila-isoindole molecules has been explored using the B3LYP/6-311G(d,p) level of theory in gas and solution phases. These calculations show that isoindole isomer has more stability rather than 1-h-isoindole. There is identical trend in silated species. The frontier molecular orbitals (FMO) and band gap energy calculations were performed at the B3LYP/6-311G(d,p) level in gas and various solvent. Solvent effects have been analyzed by using the self-consistent reaction field (SCRF) method based on polarizable continuum mo

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Sah, Pramilla, Neha Saraswat, and Manu Manu. "Synthesis of Phthalyl Substituted Imidazolones and Schiff Bases as Antimicrobial Agents." E-Journal of Chemistry 8, no. 1 (2011): 427–34. http://dx.doi.org/10.1155/2011/726315.

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A new series of phthalyl substituted imidazolones (4a–g) and Schiff bases (5a–d) were synthesized from 2-methyl-(m-nitro-1,3-dioxo-1,3-dihydro-(2H)-isoindole-2-yl)-5-amino-1,3,4-thiadiazole (3a–b). Compounds (3a–b) were prepared by cyclisation of 2-(m-nitro-1,3-dioxo-1,3-dihydro-(2H)-isoindole-2-yl)methyl ethanoate (2) with thiosemicarbazide. 2-(m-nitro-1,3-dioxo-1,3-dihydro-(2H)-isoindole-2-yl)ethanoic acid (1) in presence of thionyl chloride and methanol gave the ester (2) while compound (1) was synthesized by aminolysis of phthalic anhydride with glycine. The compounds were characterized by

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Zhao, Xue Zhi, Kasthuraiah Maddali, B. Christie Vu, et al. "Examination of halogen substituent effects on HIV-1 integrase inhibitors derived from 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-ones and 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones." Bioorganic & Medicinal Chemistry Letters 19, no. 10 (2009): 2714–17. http://dx.doi.org/10.1016/j.bmcl.2009.03.122.

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Mardjan, Muhammad Idham Darussalam, Muhamad Fadhly Hariadi, Chessy Rima Mustika, et al. "Ultrasound-assisted-one-pot synthesis and antiplasmodium evaluation of 3-substituted-isoindolin-1-ones." RSC Advances 13, no. 37 (2023): 25959–67. http://dx.doi.org/10.1039/d3ra02829a.

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A library of 3-substituted-isoindolin-1-ones has been synthesized from 3-alkylidenephtalides and primary amines through one-pot reaction under ultrasonic irradiation. Four isoindolin-1-ones have great potential to be antiplasmodium candidates.

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Ahmed, M., R. Sharma, D. P. Nagda, V. K. Salvi, and G. L. Talesara. "Synthetic studies of Alkoxy isoindole-1,3-diones tetra-azabenzo[f]azulenes and their Antibacterial activity." E-Journal of Chemistry 3, no. 1 (2006): 28–34. http://dx.doi.org/10.1155/2006/679374.

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3-Methylpyrazol-5-one3reacts with substituted benzaldehydes4a-din the presence of anhydrous sodium acetate to produce the corresponding 4-arylidene-5-methyl-2,4-dihydro-pyrazol-3-ones5a-dand the condensation of5a-dwith 2-bromoalkoxy-1H-isoindole-1, 3-(2H)-diones2a-cfurnished corresponding 2-[2-(4-arylidene-3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)alkoxy]-isoindole-1,3-diones6a-l, which on cyclisation with o-phenylendiamine give titled compounds7a-l. All the synthesized compounds have been characterized by elemental analysis and spectral data and screened for their antibacterial properties again

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45

Linnik, R., I. Levkov, A. Chemnyi, O. Radchenko, Z. Voitenko, and O. Zaporozhets. "4-Amino-Benzo[F]Isoindole-1,3-Dione Derivatives As Turn-On Fluorescent Indicators For Water Determination In Acetonitrile." Methods and Objects of Chemical Analysis, no. 4 (2018): 183–91. http://dx.doi.org/10.17721/moca.2018.183-191.

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4-Amino-9-(2,5-dioxo-pyrrolidin-1-phenyl-3-yl)-1-phenyl-benzo[f]isoindole-1,3-dione (1) and 4-amino-9-(2,5- dioxo-1-(4-methylphenyl)-pyrrolidin-3-yl)-1-(4-methylphenyl)-benzo[f]isoindole-1,3-dione (2) were studied as fluorescent indicators for water determination in acetonitrile. The intensity of fluorescence of these compounds in acetonitrile solutions increases in presence of water along with red shift of the emission peak. Intensity-based and wavelength-based procedures of water determination in acetonitrile are suggested with detection limit of 0.2 % (v/v) H2O in both cases. The linear res

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Tan, Ayse, Ayse Sahin Yaglioglu, Nurhan Horasan Kishali, Ertan Sahin, and Yunus Kara. "Evaluation of Cytotoxic Potentials of Some Isoindole-1, 3-Dione Derivatives on HeLa, C6 and A549 Cancer Cell Lines." Medicinal Chemistry 16, no. 1 (2020): 69–77. http://dx.doi.org/10.2174/1573406415666181206115638.

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Objective: Considering this information, firstly, isoindole derivatives containing different functional groups 4-13 have been synthesized from 2-alkyl/aryl-3a, 4,7,7a-tetrahydro-1H-isoindole-1, 3(2H)-dione. Background: Norcantharimides are known as norcantharidine derivatives and contain an isoindole skeleton structure. Isoindole derivatives have positive effect on inflammatory pathologies including cancers. Methods: For the synthesis of all compounds, 2-alkyl/aryl-3a, 4,7,7a-tetrahydro-1H-isoindole- 1,3(2H)-dione was used as the starting compound. The syntheses were based on two main reaction

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Biitseva, A. V., O. V. Gordienko, M. Yu Kornilov, et al. "Synthesis of 4-trifluoromethyl-3,4-dihydro-1,3,5-triazino[2,1-a]isoindol-2-ones by cyclocondensation of 1-aryl-1-chloro-2,2,2-trifluoroethyl isocyanates with 3-amino-1-arylimino-1H-isoindoles." Russian Journal of Organic Chemistry 43, no. 2 (2007): 263–70. http://dx.doi.org/10.1134/s1070428007020182.

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Dahl, Tor. "3-Amino-5,6-dicyano-1-phenylimino-1H-isoindole." Acta Crystallographica Section E Structure Reports Online 58, no. 2 (2002): o139—o141. http://dx.doi.org/10.1107/s1600536802000442.

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TAKAHASHI, Ichiro, Mikio TSUZUKI, Takashi KEUMI, et al. "A Stable Monosubstituted Isoindole Derivative: The Crystal Structure of 1-(1,2,3-1H-Benzotriazol-1-yl)-2-(4-methylphenyl)-2H-isoindole." CHEMICAL & PHARMACEUTICAL BULLETIN 42, no. 4 (1994): 947–49. http://dx.doi.org/10.1248/cpb.42.947.

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Wu, Qiong-You, Li-Li Jiang, Yang Zuo, Zhi-Fang Wang, Zhen Xi, and Guang-Fu Yang. "Synthesis,In VitroProtoporphyrinogen Oxidase Inhibition, and Herbicidal Activity ofN-(Benzothiazol-5-yl)hexahydro-1H-isoindole-1,3-diones andN-(Benzothiazol-5-yl)hexahydro-1H-isoindol-1-ones." Chemical Biology & Drug Design 84, no. 4 (2014): 431–42. http://dx.doi.org/10.1111/cbdd.12331.

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