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Dissertations / Theses on the topic 'Isoquinoline synthesis'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

Berg, Michael Arthur George. "Studies in the stereoselective synthesis of 1,1-disubstituted 1,2,3,4-tetrahydroisoquinolines." Diss., This resource online, 1992. http://scholar.lib.vt.edu/theses/available/etd-10032007-171522/.

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2

Clifton, Mary Jennifer. "Studies in stereoselective synthesis via reissert compound chemistry." Thesis, This resource online, 1991. http://scholar.lib.vt.edu/theses/available/etd-08222009-040256/.

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3

Ford, Alan John. "Synthesis of substituted isoquinoline ligands for homogeneous catalysis." Thesis, University of Hull, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361496.

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4

Muzanila, Charles Nobert. "Heterocyclic transformations involving #DELTA#'2-oxazolines and 1,2-benzisoxazoles." Thesis, University of Salford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327958.

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5

Guimond, Nicolas. "Part A: Rhodium-catalyzed Synthesis of Heterocycles / Part B: Mechanistic Studies on Tethering Organocatalysis Applied to Cope-type Alkene Hydroamination." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23222.

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The last decade has been marked by a large increase of demand for green chemistry processes. Consequently, chemists have focused their efforts on the development of more direct routes toward different classes of targets. In that regard catalysis has played a crucial role at enabling key bond formations that were otherwise inaccessible or very energy and resources consuming. The central theme of this body of work concerns the formation of C–N bonds, either through transition metal catalysis or organocatalysis. These structural units being highly recurrent in biologically active molecules, the e

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6

Hamilton, Lynne. "Synthesis, stereochemistry and reactions of quinoline, isoquinoline and acridine metabolites." Thesis, Queen's University Belfast, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334710.

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7

Si, Chong. "Synthesis of Cortistatin Alkaloids and a Versatile Synthesis of Isoquinolines." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10444.

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The cortistatins are a recently identified class of marine natural products that were found to exhibit potent and selective inhibition of human umbilical vein endothelial cells (HUVECs), making them promising leads for the development of anti-angiogenic drugs. In our synthesis, we envisioned that natural cortistatins and unnatural analogs could be prepared by late-stage introduction of isoquinolines to 17-keto precursors, and that these differentially substituted precursors could all be derived from a common key intermediate 112. We developed a robust synthetic route to prepare gram quantities

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8

Streetley, Guy Bradwell. "New approaches for the asymmetric synthesis of pyrroloisoquinoline and isoquinoline alkaloids." Thesis, Loughborough University, 2006. https://dspace.lboro.ac.uk/2134/34917.

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Pyrroloisoquinoline (n = 1) and the pyridoisoquinoline (n = 2) ring systems (2) are found to be the major structural motif of the Erythrina and the protoberberine group of alkaloids, respectively. We have recognised that suitable bicyclic lactams (1) could act as precursors, in an intramolecular N-acyliminium ion-mediated cyclisation, resulting in a stereoselective approach to the core of the Erythrina and protoberberine ring systems. [Illustration omitted.] Access to the tetracyclic core of the Erythrina alkaloids (3) through the application of N-acyliminium ion chemistry is well established

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9

Ozcan, Sevil. "Development Of New Synthetic Methodologies For The Synthesis Of Unusual Isocoumarin And Indole Derivatives:the Chemistry Of Homophthalic Acid." Phd thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/3/12608197/index.pdf.

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Many heterocyclic compounds containing nitrogen, oxygen and sulfur show wide range of physiological activities and their synthesis has always been attracted the interest of chemists. The aim of this research is to develop new synthetic methodologies leading to the synthesis of new derivatives of isocoumarines, indoles, isoquinolines, benzodiazepinones and quinazolines, which have been found to show important biological activities. Starting from homophthalic acid and bishomophthalic acid the corresponding acyl azides were proposed to be synthesized, which then would be used for the synthesis of

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10

Tinkleman, Joseph M. Smith Forrest T. "Synthesis of 10, 11, 12, 12a, 12b, 13-hexahydro-5hbenzo[f]cyclopropa[d]pyrido[1,2-b] isoquinoline-5,7(9H)dione and related compounds." Auburn, Ala, 2009. http://hdl.handle.net/10415/1655.

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11

Müller, Thomas. "C-H Activation by Nickel and Iron Catalysis." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2019. http://hdl.handle.net/21.11130/00-1735-0000-0003-C189-8.

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12

Charpentier, Langlois Patricia. "Activation d'une réaction entre un acide et une amine par reconnaissance moléculaire. Synthèse d'un récepteur d'amine." Rouen, 1995. http://www.theses.fr/1995ROUES027.

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Notre objectif a été de définir un récepteur hétérocyclique susceptible de faciliter, de manière générale, la réaction entre un acide carboxylique et une amine afin de conduire à un amide. La première partie de ce travail a consisté en l'examen de diverses stratégies d'approche de la partie tricyclique du récepteur. Nous nous sommes notamment intéressés à des dérivés de la tétrahydroisoquinoléine. A cette occasion, nous avons été amenés à apporter une contribution intéressante à la chimie de ce type de dérivés. Dans une seconde partie, nous nous sommes attachés à synthétiser la partie simplifi

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13

Bender, Christoph. "Stereoselektive Synthese neuartiger 1,2-Dihydroisochinoline als Vorstufen für die Alkaloidsynthese." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2008. http://dx.doi.org/10.18452/15728.

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Ausgangspunkte der vorliegenden Arbeit waren stereoselektive Synthesen von Reissert-Verbindungen über chirale N-Acylisochinoliniumsalze. Es galt die Konfiguration der erhaltenen Produkte zu beweisen und deren Synthesepotential zu erforschen. Ein Ziel dieser Arbeit war es, weiterführende Reaktionen für die Synthese von alkaloidanalogen Substanzen zu entwickeln. Es gelang, die Reissert-Reaktion mit Chlorameisensäurementhylester erfolgreich auf andere Heterocyclen als Isochinolin auszudehnen. Die Annahme eine stereoselektiven Verlaufes mußte korrigiert werden. Das Reissert-Produkt konnte mit eine

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14

Pilgrim, Ben Samuel. "Novel palladium-catalysed routes to aromatic heterocycles." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:d143b5bf-1738-48ce-be75-4a25249acb9d.

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A brief summary of the use of palladium as a catalyst, the characteristic reactivity of palladium complexes and the commonly used palladium-catalysed cross coupling reactions is given, with a special focus on the palladium-catalysed α-arylation of enolates and its application to the synthesis of aromatic heterocycles. The synthesis of aromatic heterocycles via both traditional methods and more recent metal-catalysed approaches is discussed in the context of isoquinolines. The palladium-catalysed oxidation of dihydrofurans bearing an ortho-bromophenyl group at the 2-position to the correspondin

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15

Blumenthal, Haiko. "Struktur und Reaktivität ausgewählter chiraler N-Acylaminohydroperoxide und -peroxide." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/15868.

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Ausgangspunkte der vorliegenden Arbeit waren stereoselektive Synthesen von Reissert-analogen N-Acylaminohydroperoxiden über chirale N-Acylisochinoliniumsalze. Edukte waren Isochinolin(derivaten), Menthylchloroformiat und Wasserstoffperoxid. Es galt die Konfiguration der erhaltenen Produkte zu beweisen und deren Sauerstoffübertragungspotential zu erforschen. Ein zweites Ziel dieser Arbeit war es, von bekannten Diketopiperazinhydroperoxiden ebenfalls das Sauerstoffübertragungspotential zu überprüfen, weil sie die gleiche N-Acylaminohydroperoxidstruktur aufweisen aber bisher wenig untersucht wurd

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16

Gatland, Alice Elizabeth. "Palladium-catalysed enolate arylation in the synthesis of isoquinolines." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:f106760d-2375-4d56-81b2-faa6ee96cabc.

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<strong>Chapter 1. Introduction</strong> Scientific background on the development of homogeneous palladium-catalysed cross coupling reactions, focusing on the α-arylation reaction of enolates and its application to the synthesis of heteroaromatic compounds. The classical syntheses of isoquinolines are discussed, followed by an account of modern methods for their synthesis, including the recent α-arylation-based methodology developed by the Donohoe group. <strong>Chapter 2. Results and Discussion</strong> 2.1 Studies towards the development of a palladium-catalysed, C–H activation-b

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17

Gavin, James Patrick. "Control of regiospecificity in the synthesis of isoquinolines." Thesis, University of Manchester, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252895.

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18

Chan, Eddy Tsz Tak. "Unsaturated sulfoxides in organic synthesis : a new furan synthesis and total synthesis of isoquinolone alkaloids." HKBU Institutional Repository, 1991. https://repository.hkbu.edu.hk/etd_ra/3.

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19

Meghani, P. "Studies of the total synthesis of CC-1065, a synthesis of PDE-I and PDE-II from isoquinolines and synthetic approaches to amphimedine." Thesis, University of Manchester, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382824.

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20

Berk, Mujde. "Development Of New Synthetic Methodologies For Isoquinolone And Isoindolinone Derivatives." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/3/12612145/index.pdf.

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ABSTRACT DEVELOPMENT OF NEW SYNTHETIC METHODOLOGIES FOR ISOQUINOLONE AND ISOINDOLINONE DERIVATIVES M&uuml<br>jde, Berk M.Sc., Department of Chemistry Supervisor: Prof. Dr. Metin Balci July 2010, 146 pages Due to the wide range of physiological activities, heterocycles containing nitrogen and oxygen have always attracted the interest of chemists. The objective of this research is to develop new synthetic routes to the synthesis of isoquinolone and isoindolinone derivatives starting from 2-(2-carboxyethyl)benzoic acid and homophthalic acid, respectively. The half ester produced from 2-(2-carboxy

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21

Chen, Chiliu. "Efforts toward the first enantioselective total synthesis of praziquantel and synthetic model studies on ecteinascidin 743 by novel aromatic C-H insertion methodology." [Tampa, Fla.] : University of South Florida, 2004. http://purl.fcla.edu/fcla/etd/SFE0000266.

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22

Taha, Mutasem O. "Some uses of acyliminium ions in the synthesis of isoquinolones with potential biological activity." Thesis, Loughborough University, 1998. https://dspace.lboro.ac.uk/2134/12608.

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The preparation of a number of 2-substituted homophthalimides through the condensation of homophthalic anhydride with different arylalkyl arnines is reported. The prepared compounds were alkylated at the 4-position to generate 4-mono-, 4,4-disubstituted and 4-spirocyclic homphthalimides, the analogues of which were reported to have interesting biological activity. Regioselective reduction of the 4-substituted derivatives generated the corresponding carbinolamides. Treating the carbinolamides with mineral or Lewis acids generated N-acyliminiurn ions, which were trapped in situ by one of the fol

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23

Sunderland, Peter T. "Design and synthesis of selective inhibitors of poly(ADP-ribose)polymerase-2." Thesis, University of Bath, 2010. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.528371.

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24

O'Mathuna, Donal P. "Part 1. Isolation and structure elucidation of diterpenes from Amphiachyris amoena (Shinners) Solbrig ; Part 2. Synthesis of methoxy-methylenedioxy isoquinolones /." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487594970653111.

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25

Pinet, Sandra. "Etude de voies d'accès aux ecteinascidines." Université Joseph Fourier (Grenoble), 1999. http://www.theses.fr/1999GRE10237.

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Les ecteinascidines, substances extraites du tunicier ecteinascidia turbinata presentent des activites biologiques interessantes aussi bien in vitro qu'in vivo. La premiere synthese de l'ecteinascidine 743, a ete realisee, dans une optique exploratoire, en 1996 par corey et coll. Ces molecules sont formees de deux fragments tetrahydroisoquinoleiques (sous-unites a et b) relies a un troisiemes fragment (sous-unite c) par une lactone soufree a dix chainons comportant un motif spiro. La sous-unite c peut etre de type tetrahydroisoquinoleine, tetra, hydrocarboline ou amino. Nous avons envisage dif

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26

Coelho, Paulo. "Etude de la diastereoselectivite des reactions intramoleculaires de composes presentant un atome de silicium chiral. Synthese de derives de 4-silatetrahydro-isochroman-1-ones, de 4-sila-2h-isoquinolein-1-ones et de silacycloalcanes." Paris 11, 1995. http://www.theses.fr/1995PA112069.

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Divers silatrienes et alcenyl(bromomethyl)silanes presentant un atome de silicium chiral ont ete synthetises en 4 a 6 etapes a partir de chlorosilanes commerciaux avec des rendements satisfaisants afin d'etudier la selectivite de reactions de diels-alder intramoleculaires et de cyclisations radicalaires intramoleculaires. Des 4-sila-4a,7,8,8a-tetrahydroisochroman-1-ones et des 4-sila-3,4,4a,7,8,8a-hexahydro-2h-isoquinolein-1-ones ont ete preparees diastereoselectivement par reaction de diels-alder intramoleculaire des acrylates, methacrylates et monomethylfumarates de 2-methyl-2-silahexa-3,5-d

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27

PRALY-DEPREZ, ISABELLE. "Synthese et etude de 11-amino-9-methoxy-5-methyl-6h-pyrido 4,3-b carbazoles et de 11-amino-5,6-dimethyl-5h-pyrido 3,4 : 4,5 pyrrolo 2,3-g isoquinoleines (nouveaux derives des ellipticines et 9-azaellipticines)." Paris 11, 1991. http://www.theses.fr/1991PA112094.

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Pour realiser la synthese des derives inedits de l'ellipticine nommes dans le titre, nous avons condense le 4-acetyl-n,n-diisopropylnicotinamide (obtenu en 4 etapes a partir de l'anhydride cynchomeronique) avec le 1-benzenesulfonyl-2-lithio-5-methoxyindole, ce qui nous a conduit au 4-1-(1-benzenesulfonyl-5-methoxyinol-2-yl)-1-hydroxyethyl-n,n-diisopropylnicotinamide. L'hydrolyse de l'amide et de la reduction de l'alcool fournissent ensuite l'acide 4-1-(1-benzenesulfonyl-5-methoxyindol-2-yl) ethyl nicotinique dont les amides sont cyclises pour conduire aux structures tetracycliques. Apres la de

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28

Delamare, Madeleine. "Nouvelles voies de synthèse d'hétérocycles polyazanaphtalènes en vue de leur application en pharmacie, en agro-industrie et en phytochimie." Rouen, 1998. http://www.theses.fr/1998ROUES024.

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L'activité de produits imidazolés vis-à-vis de l'inhibition de la farnésyl transférase a conduit au développement d'un programme de recherche industriel ayant pour base d'une part un azole et d'autre part un hétérocycle permettant une reconnaissance enzymatique spécifique. Dans le cadre de ce programme, nous nous sommes intéressés aux synthèses de divers hétérocycles de structures polyazanaphtalènes. Ainsi, des 6-acylisoquinol-1(2H)-ones, des 6- et 7-formyl-1,8-naphtyridin-2-ones et des 6- et 7-formyl-1,5-naphtyridin-2-ones, pouvant être substituées en position 3 par un groupe méthyle et en po

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29

Liu, Shih-I., and 劉士毅. "Synthesis of Tetrahydroisoquinoline Derivatives Molecular Library and Gold-Assisted Synthesis of Isoquinolino[1,2-a]isoquinoline Derivatives." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/22843163564865086291.

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碩士<br>國立交通大學<br>應用化學系碩博士班<br>105<br>Use Pictet-Spengler reaction to synthesize tetrahydroisoquinoline then react with isocyanate, isothiocyanate, isoselenocyanate via [3 + 2] cycloaddition to obtain imidazo[1,5-b]isoquinoline, or react with chloroacetyl chloride then follow by primary amine to obtain pyraz[1,2-b]isoquinoline, and build up the molecular libraries. Gold-Assisted one-pot two-step synthesis of isoquinolino[1,2-a]isoquinoline. First step undergo Pictet-Spengler reaction, then second step follow by gold catalyze 6-endo-dig cyclization to give the isoquinolino[1,2-a]isoquinoline.

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30

Yu-Chen, Wu, and 吳育真. "Nickel-Catalyzed Synthesis of Isoquinoline Derivatives." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/91992194016068934547.

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31

Yang, Huei-Ting, and 楊惠婷. "Synthesis of Benzofuran, Fused Isoindolinone and Isoquinoline Derivatives." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/28459742252781734765.

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碩士<br>國立臺灣師範大學<br>化學系<br>104<br>The content of the thesis is divided into two parts. The first part focuses on the chemistry of the nitro alkenes and its application in the synthesis of naphthofuran derivatives. The methodology is based on one-pot base mediated tandem reaction of β-nitrostyrene derivatives and 2-naphthol, 1,4-Michael addition and intramolecular cyclization. A wide variety of naphthofuran derivatives were synthesized in relatively good yields under mild condition. The second part describes about the synthesis of fused isoindolinone and isoquinoline derivatives in two step proc

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Chen, Chih-Jen, and 陳致壬. "Synthesis of Isoquinoline via Aerobic Oxidation of Indene Derivatives." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/h3wbqg.

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碩士<br>中原大學<br>化學研究所<br>102<br>The purpose of this study was to investigate the synthesis of isoquinolines, from indene derivatives with urea and oxygen via one-pot reaction. It was found that the best yield was obtained by using of a 3:2 mixture of 1,4-dioxane and toluene as solvent. Transition metal catalyst was not needed in this reaction. Previausly reported syntheses of isoquinoline derivatives were carried out in acidic conditions or needed a transition metal as catalyst in the reaction. In this research, out method is metal-free and the reaction condition is relativily mild.

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Chen, Ying-Hui, and 陳盈惠. "Novel Synthesis of 1-Phenyl-4-hydroxy-isoquinoline Derivatives." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/z8dggr.

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碩士<br>中國醫藥大學<br>藥學系碩士班<br>101<br>For many years isoquinolines have been an interesting structural class of compounds, and their derivatives, 4-hydroxyisoquinolines, exhibited a range of physiological activities. Due to its wide applications in the field of pharmaceuticals, this type of compounds has attracted our attention. We developed an efficient method to synthesize 4-hydroxy-1-phenylisoquinolines from methyl N-(diphenylmethylene)glycinates via the loss of methanol followed by intramolecular electronic cyclization. A series of 3-substituted 4-hydroxy-1-phenylisoquinolines was synthesized,

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Sonopo, Molahlehi Samuel. "Strategies for the synthesis of benzyltetrahydroisoquinoline alkaloids." Thesis, 2011. http://hdl.handle.net/10413/8080.

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The objectives of this project were to investigate the application of new methodologies for the preparation of benzyltetrahydroisoquinoline monomers and secondly, to synthesise the bisbenzyltetrahydroisoquinoline neferine and its analogues. Neferine was isolated from the roots of Nelumbo nucifera. This compound has been reported to exhibit important biological activities, which include anti-arrhymia, anti-platelet aggregation, anti-thrombosis, anti-cancer as well as anti-HIV activities. Moreover, neferine showed lower cytotoxicity compared to other isoquinolines. However, the total synthesis o

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Prasad, K. Pajendra. "Nickel and Iridium Catalyzed Synthesis of Isoquinoline, Quinolines, Arylalkynes and Flavanones." 2006. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0016-1303200709261896.

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Lotter, Angelique Natalia Cassandra. "A Novel Method for the Synthesis of Indolo[2,1-a]isoquinolines." Thesis, 2006. http://hdl.handle.net/10539/1504.

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MSc dissertation School of Chemistry Faculty of Science 0004984F<br>Many azapolycyclic aromatic ring systems, whether they are naturally occurring or synthetically made, display important biological activities. One important class of naturally occurring azapolycyclic aromatic ring systems are the dibenzopyrrocoline alkaloids, which contain an indole ring fused to an isoquinoline moiety, where they share a common nitrogen. The basic skeleton of these alkaloids is the indolo[2,1-a]isoquinoline nucleus. Both the dibenzopyrrocoline alkaloids and the indolo[2,1-a]isoquinolines have been f

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Brusnahan, Jason Stewart. "Total synthesis of ancistrotanzanine A." 2010. http://hdl.handle.net/2440/60142.

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This thesis describes the first total synthesis of ancistrotanzanine A, a member of the naphthylisoquinoline class of natural products. In Chapter 1 the synthetic challenges presented by the naphthylisoquinoline alkaloids are discussed and strategies that have been adopted in previous syntheses of naphthylisoquinoline alkaloids overviewed. Chapter 2 describes the preparation of the key 5,3'-biaryl linkage via the Pinhey-Barton reaction. Studies into forming the linkage atropselectively were investigated using chiral hydrobenzoin acetal auxiliaries. This was found to have limited success with a

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Teng, Chu-Chun, and 鄧竹君. "Nickel-Catalyzed Synthesis of Isoquinoline Salts and the Application in the Total Synthesis of (±)-Salsolidine and (±)-Carnegine." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/02618033844459772716.

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Sello, Thato Saoeni. "A novel method for the synthesis of Indolo[2,1-a]isoquinolines and modelling studies of 3-substituted oxindoles against PfPK5." Thesis, 2008. http://hdl.handle.net/10539/5598.

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Many naturally occurring and synthetically made azapolycyclic aromatic ring systems display important biological activities. One class of naturally occurring azapolycyclic aromatic ring systems is the dibenzopyrrocoline alkaloids, made from an indole nucleus fused to an isoquinoline system sharing the same nitrogen, i.e. the indolo[2,1-a]isoquinoline nucleus. The indolo[2,1-a]isoquinoline and its analogues have been reported to possess antileukemic, tubulin polymerization inhibitory and antitumor activity. A variety of indolo[2,1-a]isoquinolines have been synthesized in our labs. This

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Kuo, Reen-Yen, and 郭荏耘. "Chemical and Biological Studies on the Constituents of Rollinia mucosa Baill. and the Synthesis of Isoquinoline Derivatives." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/84767661870035281015.

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博士<br>高雄醫學大學<br>藥學研究所<br>91<br>In the continuing research of Formosan Annonaceous plants, the methanolic extracts of leaves and stems of Rollinia mucosa Baill. were investigated for their chemical constituents and biological activities, respectively. Fifty-one compounds were isolated including twenty-eight alkaloids, three flavonoids, six lignans, five steroids, one acetogenin, one pyrrole, and seven benzenoids. Among these compounds, eight of them including (-)-artabonatine A (AP-10), romucosine A-D (AP-13~16), promucosine (PA-2), rollipyrrole (PY-1) and romucosine I (PH-1) are isolated as ne

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Tao, Ying-Shin, and 陶應興. "Part I: Application of Electrooxidation Reaction Toward the Synthesis of Atropine Alkaloids.PartII: Application of Electroreduction Reaction Toward the Synthesis of Carboline and Isoquinoline Alkaloids." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/63218305303355166158.

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碩士<br>國立中山大學<br>化學系研究所<br>90<br>Part1: Application of electrooxidation reaction toward the synthesis of atropine allcaloids and synthesis of cocaine alkaloids. Part2: Application of electroreduction reaction toward the synthesis of yohimbine alkaloids.

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Chuang, Sheng-Cheh, and 莊勝絜. "Rhodium-Catalyzed C－H Bond Activation and the Application to the Synthesis of Isoquinoline Derivatives from Hydrazones and Alkynes." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/79627772430231301289.

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Huang, Tzu-Lin, and 黃子霖. "Acid-Promoted Intramolecular Cyclization of Silyl-Protected 2-(3-Arylpropargyltosylaminomethyl)cyclohex-2-en-1-ols－ Synthesis of Isoquinoline Derivatives." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/49709291962998077934.

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碩士<br>國立臺灣師範大學<br>化學系<br>101<br>Lewis acid and TfOH-mediated intramolecular cyclization reaction of tert-butyldimethylsilyl-protected 2-(3-arylpropargyltosylaminomethyl) cyclohex-2-en-1-ols afforded isoquinoline derivatives. 　　The use of BF3•OEt2 for the cyclization/fluorination of silyl-protected 2-(3-arylpropargyltosylaminomethyl)cyclohex-2-en-1-ols produced isoquinoline derivatives containing a C(sp2)-F bond. In this reaction, BF3•OEt2 reacted as both the Lewis acid and the fluoride source. The reaction generates a new C(sp2)-F bond and an octahydroisoquinoline skeleton at ambient temperatu

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Li, Chien-Le, and 李建樂. "Organic Light-Emitting Diode Materials based on Finite Oligo(arylenevinylene) Derivatives and Iridium-Isoquinoline Complexes: Synthesis, Photochemical Study and Device Application." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/45787269972149221047.

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博士<br>國立清華大學<br>化學系<br>91<br>Part I : A series of oligo(phenylenevinylene) (OPV) derivatives with finite conjugation units were prepared in short steps from few building blocks. The central and terminal aryl groups of these OPV dyes contain a cyano and Ph2N substituents respectively, which affect color of fluorescence. The wavelength ranges from 472 nm (blue) to 614 nm (red) depending on the position of the cyano group. Part II : We report the synthesis and OLED devicesof a series of iridium-phenyl-1- isoquino line complexes with fluoro-substituents on the isoq

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黃鈺雅. "(一) Lewis Acid-Promoted Intramolecular Cyclization of Silyl- Protected 2-(3-Arylpropargyltosylamino)methylcyclohex- 2-en-1-ols : Synthesis of Isoquinoline Derivatives (二) Brønsted Acid-Assisted Alkyne-Aldehyde Metathesis of 1-(3-Arylprop-2-yn-1-yl)-2-formylpyrrolidine : Synthesis of Pyrrolizine Derivatives". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/09935030685465322120.

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碩士<br>國立臺灣師範大學<br>化學系<br>102<br>This thesis focuses on acid-promoted intramolecular cyclization of N-containing O-silyl-protected enynols and N-containing ynals. Three major reactions are discussed. First, FeCl3-promoted cyclization of O-silyl-protected 2-(3-arylpropargyltosylamino)methylcyclohex-2-en-1-ols in the air at room temperature produced isoquinoline derivatives containing an aryl(chloro)methylene moiety. In this process, FeCl3 acts as both the activating group and the chloride source. Second, BF3-promoted intramolecular cyclization of O-silyl-protected 2-(3-arylpropargyltosylamino)me

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LIN, JIN-HUI, and 林錦慧. "Asymmetric synthesis of tetrahydro-benzylisoquinolines Synthetic study of novel isoquinolines with antiplatelet effect." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/88212261298390808315.

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Huang, Wei Zhan, and 黃偉展. "The synthesis and bioactivity of 1-Phenyltetrahydro-isoquinolines." Thesis, 1995. http://ndltd.ncl.edu.tw/handle/94589734394397598682.

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Jih-Chao, Hong, and 洪日昭. "Part I：Electroorganic Syntheses of Carbolines and Isoquinolines. Part II：Application of Radical Cyclization to Synthesize Alkaloids." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/40879428899405937816.

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Hozová, Miroslava. "Synthesis of novel acetylcholinesterase reactivators of isoquinolinic type." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-368478.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Student: Miroslava Hozová Supervisor: PharmDr. Jaroslav Roh, Ph.D. Consultant: RNDr. Dávid Maliňák, Ph.D. Title of Diploma Thesis: Synthesis of novel acetylcholinesterase reactivators of isoquinolinic type Organophosphates are worldwide the most common cause of poisoning, whether in the field of agriculture, attempted suicide, accidental contact or abuse as organophosphorus nerve agents. They can be absorbed by all paths - inhaled, ingest or by transdermal penetration. For over 50 years the

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Kuo, Chen-Yuan, and 郭振源. "The Synthesis of Derivatives of 1-Substituted Isoquinolines and Their Biological Activity." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/26822841844904444597.

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博士<br>高雄醫學大學<br>藥學研究所博士班<br>94<br>Isoquinoline alkaloids are interested due to their widespread occurrence in nature and broad biological effects. A series of 1-(2-nitro phenyl)-3,4-dihydroisoquinolines were reduced under very mild reaction conditions in the presence of Tin(Ⅱ) chloride dihydrate (SnCl2.2H2O) to give 5,6-dihydroindazolo[3,2-a]isoquinolines 4a-i. A mechanism for this reaction is proposed and their antitumor activity was evaluated. Besides, phenoxyalkylamino moiety is known to be the mother structure of α-blockers and many benzylisoquimoline- based alkaloids exhibitd excellent an

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