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Journal articles on the topic 'Isorhamnetin'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 July 2025

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1

Rodríguez, Lyanne, Lina Badimon, Diego Méndez, et al. "Antiplatelet Activity of Isorhamnetin via Mitochondrial Regulation." Antioxidants 10, no. 5 (2021): 666. http://dx.doi.org/10.3390/antiox10050666.

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With the diet, we ingest nutrients capable of modulating platelet function, which plays a crucial role in developing cardiovascular events, one of the leading causes of mortality worldwide. Studies that demonstrate the antiplatelet and antithrombotic potential of bioactive compounds are vital to maintaining good cardiovascular health. In this work, we evaluate the flavonol isorhamnetin’s antiplatelet effect on human platelets, using collagen, thrombin receptor activator peptide 6 (TRAP-6), and phorbol myristate acetate (PMA) as agonists. Isorhamnetin induced a significant inhibition on collage

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2

González-Arceo, Maitane, Iván Gomez-Lopez, Helen Carr-Ugarte, et al. "Anti-Obesity Effects of Isorhamnetin and Isorhamnetin Conjugates." International Journal of Molecular Sciences 24, no. 1 (2022): 299. http://dx.doi.org/10.3390/ijms24010299.

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Isorhamnetin is a plant-derived secondary metabolite which belongs to the family of flavonoids. This review summarises the main outcomes described in the literature to date, regarding the effects of isorhamnetin on obesity from in vitro and in vivo studies. The studies carried out in pre-adipocytes show that isorhamnetin is able to reduce adipogenesis at 10 μM or higher doses and that these effects are mediated by Pparγ and by Wnt signalling pathway. Very few studies addressed in rodents are available so far. It seems that treatment periods longer than two weeks are needed by isorhamnetin and

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3

Alqudah, Abdelrahim, Esam Y. Qnais, Mohammed A. Wedyan, et al. "Isorhamnetin Reduces Glucose Level, Inflammation, and Oxidative Stress in High-Fat Diet/Streptozotocin Diabetic Mice Model." Molecules 28, no. 2 (2023): 502. http://dx.doi.org/10.3390/molecules28020502.

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Background: Isorhamnetin is a flavonoid that is found in medical plants. Several studies showed that isorhamnetin has anti-inflammatory and anti-obesity effects. This study aims to investigate the anti-diabetic effects of isorhamnetin in a high-fat diet and Streptozotocin-(HFD/STZ)-induced mice model of type 2 diabetes. Materials and Methods: Mice were fed with HFD followed by two consecutive low doses of STZ (40 mg/kg). HFD/STZ diabetic mice were treated orally with isorhamnetin (10 mg/kg) or (200 mg/kg) metformin for 10 days before sacrificing the mice and collecting plasma and soleus muscle

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4

UNVER, Tuba. "Isorhamnetin as a promising natural bioactive flavonoid: in vitro assessment of its antifungal property." International Journal of Agriculture, Environment and Food Sciences 8, no. 1 (2024): 54–61. http://dx.doi.org/10.31015/jaefs.2024.1.6.

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Isorhamnetin (3’-methylquercetin) is an important flavonoid produced as a secondary metabolite from medicinal and aromatic plants due to its pharmacological and therapeutic properties. Thus far, the anticancer, antiallergic, antiinflammatory, antioxidant, antiviral, and antimicrobial properties of isorhamnetin have been evaluated in indirect studies conducted with isorhamnetin found in plant extracts or essential oils or direct studies performed with pure isorhamnetin. However, this is the first study in the literature on the antifungal activity of 97% pure isorhamnetin against C. tropicalis,

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5

Koga, Takeru, Hideyuki Ito, Yuji Iwaoka, Toshiro Noshita, and Akihiro Tai. "Neurite Outgrowth-Promoting Compounds from the Petals of Paeonia lactiflora in PC12 Cells." Molecules 27, no. 22 (2022): 7670. http://dx.doi.org/10.3390/molecules27227670.

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Isorhamnetin-3-O-glucoside and astragalin, flavonol glucosides, were isolated from the petals of Paeonia lactiflora as neurite outgrowth-promoting compounds. Isoquercitrin, formed by demethylating the B ring of isorhamnetin-3-O-glucoside or by adding a hydroxyl group to the B ring of astragalin, was evaluated for neurite outgrowth-promoting activity and was compared with the activities of isorhamnetin-3-O-glucoside and astragalin. The activities of isorhamnetin, kaempferol, and quercetin, aglycones corresponding to isorhamnetin-3-O-glucoside, astragalin, and isoquercitrin, respectively, were a

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6

Timmermann, Barbara N., Susanne Valcic, Yong-Long Liu, and Gloria Montenegro. "Notes: Flavonols from Cryptocarya alba." Zeitschrift für Naturforschung C 50, no. 11-12 (1995): 898–99. http://dx.doi.org/10.1515/znc-1995-11-1223.

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Ten flavonoids and chlorogenic acid were isolated from the leaves and stems of Cryptocarya alba (Lauraceae). The flavonoids were identified as isorhamnetin. kaempferol, quercetin and their glycosides isorhamnetin-3-O-rhamnoside, isorhamnetin-3-O-galactoside, isorhamnetin-3-O-glucoside, kaempferol-3-O-galactoside, quercetin-3-O-rhamnoside (quercitrin), quercetin-3-O- galactoside (hyperoside), and quercetin-3-O-glucoside (isoquercitrin).

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7

Aonuma, Kazuhiro, DongZhu Xu, Nobuyuki Murakoshi, et al. "Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation." Clinical Science 136, no. 24 (2022): 1831–49. http://dx.doi.org/10.1042/cs20220319.

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Abstract Isorhamnetin, a natural flavonoid, has strong antioxidant and antifibrotic effects, and a regulatory effect against Ca2+-handling. Atrial remodeling due to fibrosis and abnormal intracellular Ca2+ activities contributes to initiation and persistence of atrial fibrillation (AF). The present study investigated the effect of isorhamnetin on angiotensin II (AngII)-induced AF in mice. Wild-type male mice (C57BL/6J, 8 weeks old) were assigned to three groups: (1) control group, (2) AngII-treated group, and (3) AngII- and isorhamnetin-treated group. AngII (1000 ng/kg/min) and isorhamnetin (5

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8

Sindhuja A, Sindhuja A., Vimalavathini R. Vimalavathini R, and Kavimani S. Kavimani S. "In silico Docking Studies of Antiglycation Activity of Isorhamnetin on Molecular Proteins of Advanced Glycation end Product (AGE) Pathway." Biomedical and Pharmacology Journal 14, no. 4 (2021): 2299–306. http://dx.doi.org/10.13005/bpj/2331.

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Advanced glycation end products (AGEs) are formed excessively in pathological conditions due to non - enzymatic glycation of proteins, lipids or nucleic acids, affecting their structure and function. Isorhamnetin is a naturally occurring flavonoid with anti-inflammatory, anti-oxidant, anti-obesity, anticancer, anti-diabetic and anti-atherosclerosis activity. Structure activity studies of isorhamnetin reveal the presence of hydroxyl group in the B-ring of isorhamnetin may contribute to antiglycation activity. Hence we hypothised that isorhamnetin may have antiglycation activity owing to its str

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9

Park, Cha, Choi, et al. "Isorhamnetin Induces Cell Cycle Arrest and Apoptosis Via Reactive Oxygen Species-Mediated AMP-Activated Protein Kinase Signaling Pathway Activation in Human Bladder Cancer Cells." Cancers 11, no. 10 (2019): 1494. http://dx.doi.org/10.3390/cancers11101494.

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Isorhamnetin is an O-methylated flavonol that is predominantly found in the fruits and leaves of various plants, which have been used for traditional herbal remedies. Although several previous studies have reported that this flavonol has diverse health-promoting effects, evidence is still lacking for the underlying molecular mechanism of its anti-cancer efficacy. In this study, we examined the anti-proliferative effect of isorhamnetin on human bladder cancer cells and found that isorhamnetin triggered the gap 2/ mitosis (G2/M) phase cell arrest and apoptosis. Our data showed that isorhamnetin

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10

Chauhan, Anil Kumar, Jieun Kim, Yeongjoon Lee, Pavithra K. Balasubramanian, and Yangmee Kim. "Isorhamnetin Has Potential for the Treatment of Escherichia coli-Induced Sepsis." Molecules 24, no. 21 (2019): 3984. http://dx.doi.org/10.3390/molecules24213984.

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Isorhamnetin is a flavonoid that is abundant in the fruit of Hippophae rhamnoides L. It is widely studied for its ability to modulate inflammatory responses. In this study, we evaluated the potential of isorhamnetin to prevent gram-negative sepsis. We investigated its efficacy using an Escherichia coli-induced sepsis model. Our study reveals that isorhamnetin treatment significantly enhances survival and reduces proinflammatory cytokine levels in the serum and lung tissue of E. coli-infected mice. Further, isorhamnetin treatment also significantly reduces the levels of aspartate aminotransfera

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11

Settu, Kandakumar, and Manju Vaiyapuri. "FORMULATION AND EVALUATION OF ISORHAMNETIN LOADED POLY LACTIC-CO-GLYCOLIC ACID NANOPARTICLES." Asian Journal of Pharmaceutical and Clinical Research 10, no. 11 (2017): 177. http://dx.doi.org/10.22159/ajpcr.2017.v10i11.19918.

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Objective: The aim of the present study was formulation and evaluation of isorhamnetin loaded poly lactic-co-glycolic acid (PLGA) polymeric nanoparticles (NPs).Methods: The present study was designed to incorporate the isorhamnetin in PLGA formulation by double emulsion solvent evaporation method, which offers a dynamic and flexible technology for enhancing drug solubility due to their biphasic characteristic, variety in design, composition and assembly. Synthesized isorhamnetin-PLGA NPs were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), a

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12

Zainul, Rahadian, Dheo Shalsabilla Novel, and Herland Satriawan. "Interaction of Isorhamnetin in Red Onion (Allium cepa) with Xanthine Dehydrogenase as Purine Metabolism." International Journal on Computational Engineering 1, no. 1 (2024): 27–32. http://dx.doi.org/10.62527/comien.1.1.7.

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This research aims to study the interaction between Isorhamnetin compound and Xanthine Dehydrogenase enzyme in onion (Allium cepa) as part of purine metabolism. The research methods used include the use of Pymol, Pyrex, Protein Plus, and Lepinski Rule software. The use of Pymol was used to visualize the structure of Isorhamnetin and Xanthine Dehydrogenase in the interaction complex. The use of Pyrex was used for the calculation of binding affinity (kcal/moles) between Isorhamnetin and Xanthine Dehydrogenase, with results of -8.2, -7.9, and -7.9. Protein Plus indicated the interaction between I

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13

Nishiyama, Yuichi, Akinori Morita, Shogo Tatsuta, et al. "Isorhamnetin Promotes 53BP1 Recruitment through the Enhancement of ATM Phosphorylation and Protects Mice from Radiation Gastrointestinal Syndrome." Genes 12, no. 10 (2021): 1514. http://dx.doi.org/10.3390/genes12101514.

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Flavonoids are a subclass of polyphenols which are attractive, due to possessing various physiological activities, including a radioprotective effect. Tumor suppressor p53 is a primary regulator in the radiation response and is involved in the pathogenesis of radiation injuries. In this study, we revealed that isorhamnetin inhibited radiation cell death, and investigated its action mechanism focusing on DNA damage response. Although isorhamnetin moderated p53 activity, it promoted phosphorylation of ataxia telangiectasia mutated (ATM) and enhanced 53BP1 recruitment in irradiated cells. The rad

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14

Guo, Zhenli, Shizhong Liu, Xianghong Hou, et al. "Isorhamnetin Attenuates Isoproterenol-Induced Myocardial Injury by Reducing ENO1 (Alpha-Enolase) in Cardiomyocytes." Antioxidants 14, no. 5 (2025): 579. https://doi.org/10.3390/antiox14050579.

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The protective effect of isorhamnetin on myocardial injury induced by isoproterenol (ISO) was investigated to identify the key targets and pathways involved, offering potential therapeutic insights for cardiovascular diseases. A myocardial injury model was established through intraperitoneal ISO injection, and the effects of isorhamnetin on apoptosis and oxidative stress in ISO-induced myocardial injury rats were assessed. Additionally, an ISO-induced H9c2 cell injury model was established to evaluate the impact of isorhamnetin on cellular damage. The transcriptomic sequencing of H9c2 cells wa

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15

Lee, Ho K., Jinhong Park, Bo-Rahm Kim, Ikhyun Jun, Tae-im Kim, and Wan Namkung. "Isorhamnetin Ameliorates Dry Eye Disease via CFTR Activation in Mice." International Journal of Molecular Sciences 22, no. 8 (2021): 3954. http://dx.doi.org/10.3390/ijms22083954.

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Dry eye disease is one of the most common diseases, with increasing prevalence in many countries, but treatment options are limited. Cystic fibrosis transmembrane conductance regulator (CFTR) is a major ion channel that facilitates fluid secretion in ocular surface epithelium and is a potential target of therapeutic agent for the treatment of dry eye disease. In this study, we performed a cell-based, high-throughput screening for the identification of novel natural products that activate CFTR and restore the aqueous deficiency in dry eye. Screening of 1000 natural products revealed isorhamneti

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16

Kim, Min, Seung-Cheol Jee, Min-Kyoung Shin, et al. "Quercetin and Isorhamnetin Reduce Benzo[a]pyrene-Induced Genotoxicity by Inducing RAD51 Expression through Downregulation of miR−34a." International Journal of Molecular Sciences 23, no. 21 (2022): 13125. http://dx.doi.org/10.3390/ijms232113125.

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Benzo[a]pyrene (B[a]P) is metabolized in the liver into highly reactive mutagenic and genotoxic metabolites, which induce carcinogenesis. The mutagenic factors, including B[a]P-7,8-dihydrodiol-9,10-epoxide (BPDE) and reactive oxygen species, generated during B[a]P metabolism can cause DNA damage, such as BPDE-DNA adducts, 8-oxo-dG, and double-strand breaks (DSBs). In this study, we mechanistically investigated the effects of quercetin and its major metabolite isorhamnetin on the repair of B[a]P-induced DNA DSBs. Whole−transcriptome analysis showed that quercetin and isorhamnetin each modulate

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17

Habtamu, Abere, and Yadessa Melaku. "Antibacterial and Antioxidant Compounds from the Flower Extracts of Vernonia amygdalina." Advances in Pharmacological Sciences 2018 (2018): 1–6. http://dx.doi.org/10.1155/2018/4083736.

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Vernonia amygdalina is traditionally used in Ethiopia to treat various diseases. This prompted us to isolate bioactive compounds from the flowers of this plant. The CHCl3 extract after silica gel column chromatography has led to the isolation of two compounds identified as tricosane (1) and vernolide (2), while the acetone extract furnished isorhamnetin (3) and luteolin (4). The acetone extract and isorhamnetin significantly scavenged the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical by 91.6 and 94%, respectively. It was also shown that the acetone extract and isorhamnetin inhibited lipid perox

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18

Greifová, Hana, Katarína Tokárová, Tomáš Jambor, et al. "Isorhamnetin Influences the Viability, Superoxide Production and Interleukin-8 Biosynthesis of Human Colorectal Adenocarcinoma HT-29 Cells In Vitro." Life 13, no. 9 (2023): 1921. http://dx.doi.org/10.3390/life13091921.

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Isorhamnetin has gained research interest for its anti-inflammatory, anti-proliferative and chemoprotective properties. In this study, human colon adenocarcinoma cells were cultured in the presence or absence of different isorhamnetin concentrations (5–150 μM) for 24 h or 48 h of cultivation to explore the impact on several parameters of viability/proliferation (mitochondrial function using an MTT test, metabolic activity, cell membrane integrity and lysosomal activity using a triple test). The intracellular generation of superoxide radicals using an NBT test and ELISA analysis was performed t

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Ekici, M., H. Güngör, and DG Mert. "Kaempferol and Isorhamnetin alleviate Lipopolysaccharide-Induced Anxiety and Depression-Like Behavioral in Balb/C Mice." Journal of the Hellenic Veterinary Medical Society 74, no. 2 (2023): 5749–60. http://dx.doi.org/10.12681/jhvms.30232.

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The etiology of anxiety and depression is linked to inflammation and oxidative stress. Isorhamnetin and Kaempferol are strong antioxidants with antiinflammatory and neuroprotective properties. This study, it was aimed to investigate the effect of Kaempferol and Isorhamnetin in Lipopolysaccharide (LPS)-induced anxiety and depression model in mice. Thirty Balb/C mice were divided into six groups of five mice each weighing 25-35 gr. Kaempferol (50 mg/kg and 100 mg/kg) and Isorhamnetin (30 mg/kg and 60 mg/kg) were given orally to the treatment group, and the vehicle was given to the control and LP

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20

Chen, Anna, Na Gu, Jianjun Pei, et al. "Synthesis of Isorhamnetin-3-O-Rhamnoside by a Three-Enzyme (Rhamnosyltransferase, Glycine Max Sucrose Synthase, UDP-Rhamnose Synthase) Cascade Using a UDP-Rhamnose Regeneration System." Molecules 24, no. 17 (2019): 3042. http://dx.doi.org/10.3390/molecules24173042.

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Isorhamnetin-3-O-rhamnoside was synthesized by a highly efficient three-enzyme (rhamnosyltransferase, glycine max sucrose synthase and uridine diphosphate (UDP)-rhamnose synthase) cascade using a UDP-rhamnose regeneration system. The rhamnosyltransferase gene (78D1) from Arabidopsis thaliana was cloned, expressed, and characterized in Escherichia coli. The optimal activity was at pH 7.0 and 45 °C. The enzyme was stable over the pH range of 6.5 to 8.5 and had a 1.5-h half-life at 45 °C. The Vmax and Km for isorhamnetin were 0.646 U/mg and 181 μM, respectively. The optimal pH and temperature for

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Ye, Lei, Run-Hui Ma, Xiu-Xiu Zhang, et al. "Isorhamnetin Induces Apoptosis and Suppresses Metastasis of Human Endometrial Carcinoma Ishikawa Cells via Endoplasmic Reticulum Stress Promotion and Matrix Metalloproteinase-2/9 Inhibition In Vitro and In Vivo." Foods 11, no. 21 (2022): 3415. http://dx.doi.org/10.3390/foods11213415.

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Endometrial cancer (EC) is a very common female cancer which has attracted more and more attention. According to the individual patient’s condition, the current treatment of EC patients is mainly based on surgery, which is supplemented by chemotherapy, radiotherapy, and endocrine intervention. However, these existing treatment strategies also have some inevitable limitations. Therefore, it is particularly important to find an active ingredient with low toxicity and a high safety profile against EC. Isorhamnetin is a flavonoid known to be present in a variety of plants, such as sea buckthorn, d

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22

Kacem, Nassira, Anne-Emmanuelle Hay, Andrew Marston, Amar Zellagui, Salah Rhouati, and Kurt Hostettmann. "Antioxidant Compounds from Algerian Convolvulus tricolor (Convolvulaceae) Seed Husks." Natural Product Communications 7, no. 7 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700716.

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Seed husk extracts of Convolvulus tricolor L. (Convolvulaceae) afforded six compounds, identified for the first time from this plant: isorhamnetin 3- O-β-D-galactopyranoside (1), isorhamnetin 3- O-β-D-(6″-acetyl)-galactopyranoside (2), isorhamnetin 3- O-robinobioside (3), 3,4-di- O-caffeoylquinic acid (4), gentisic acid 5- O-glucoside (5), and scopoletin (6). Separation of compounds was carried out by CC and CPC. Structural elucidations were performed by HPLC-UV-DAD, HPLC-ESI/MS (negative mode) and NMR.

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23

Zhang, X. D., A. C. Allan, X. Q. Chen, et al. "Coloration, anthocyanin profile and metal element content of Yunnan Red Pear (Pyrus pyrifolia)." Horticultural Science 39, No. 4 (2012): 164–71. http://dx.doi.org/10.17221/265/2011-hortsci.

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The pigmentation response, coloration components and the metal elemental content of Yunnan Red Pear were studied. Light is indispensable for peel pigmentation. With increasing duration of illumination of fruit, the area of skin colour and colour intensity of peel increases due to accumulation of anthocyanin. The red anthocyanin component of Yunnan Red Pear skin is cyanidin-3-O-galactoside. Other phenolic compounds in pear skin are chlorogenic acid, isorhamnetin-3-O-galactoside and isorhamnetin-3-O-6"-malonylgalactoside; or isorhamnetin-3-O-6"-malonylglucoside; or isorhamnetin-3-O-malonylgalact

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24

Ahn, Hyung Jin, Hyun Ju You, Myeong Soo Park, et al. "Microbial biocatalysis of quercetin-3-glucoside and isorhamnetin-3-glucoside in Salicornia herbacea and their contribution to improved anti-inflammatory activity." RSC Advances 10, no. 9 (2020): 5339–50. http://dx.doi.org/10.1039/c9ra08059g.

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Bifidobacterium animalis subsp. lactis AD011 catalyzed >85% of quercetin-3-glucoside and isorhamnetin-3-glucoside into quercetin (Q) and isorhamnetin (IR), respectively, in 2 h. These Q and IR showed improved anti-inflammatory activity.

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Landa, Amaya, Raquel Casado, and M. Isabel Calvo. "Identification and Quantification of Flavonoids from Chuquiraga spinosa (Asteraceae)." Natural Product Communications 4, no. 10 (2009): 1934578X0900401. http://dx.doi.org/10.1177/1934578x0900401008.

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Nine flavonol glycosides (quercetin-3-O-glucuronide, quercetin-3-O-rutinoside, quercetin-3-O-glucoside, kaemperol-3-O-glucuronide, kaemperol-3-O-rutinoside, kaempherol-3-O-glucoside, isorhamnetin-3-O-glucuronide, isorhamnetin-3-O-rutinoside and isorhamnetin-3-O-glucoside) were isolated from the aerial parts of Chuquiraga spinosa (R. et P.) D. Don (Asteraceae). The identification of the compounds was carried out by HPLC/DAD, HPLC/MS and NMR analysis. These compounds may be useful in the chemotaxonomy of the genus and species.

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de Aquino, Anansa Bezerra, Luiz Henrique Agra Cavalcante-Silva, Carolina Barbosa Brito da Matta, et al. "The Antinociceptive and Anti-Inflammatory Activities ofAspidosperma tomentosum(Apocynaceae)." Scientific World Journal 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/218627.

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We investigated the antinociceptive and anti-inflammatory activities of the crude ethanolic extract (CEE), its fractions, and the flavonoid isorhamnetin fromAspidosperma tomentosumusing models of nociception and inflammation in mice. In the writhing test, the CEE and its fractions (except for soluble phase, CHCl3100% and EtAcO 100%) at 100 mg/kg p.o. induced antinociceptive activity. Isorhamnetin (100 μmol/kg, p.o.) was also active. In the hot plate test, only the treatment with the fractions Hex : CHCl350%, CHCl3100%, and CHCl3 : MeOH 5% (100 mg/kg, p.o.) increased the latency time, reversed

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Gammoh, Omar, Esam Y. Qnais, Rabaa Y. Athamneh, et al. "Unraveling the Potential of Isorhamnetin as an Adjuvant in Depression Treatment with Escitalopram." Current Issues in Molecular Biology 45, no. 9 (2023): 7668–79. http://dx.doi.org/10.3390/cimb45090484.

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Oxidative stress and inflammation are implicated in depression. While selective serotonin reuptake inhibitors (SSRIs) like escitalopram are commonly prescribed as first-line treatments, their inconsistent efficacy and delayed onset of action necessitates the exploration of adjunctive therapies. Isorhamnetin, a flavonol, has shown antioxidant and anti-inflammatory properties that makes exploring its antidepressant effect attractive. This study aims to investigate the adjuvant potential of isorhamnetin in combination with escitalopram to enhance its antidepressant efficacy in a lipopolysaccharid

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S, Kandakumar, and V. Manju Dr. "Pharmacological Applications of Isorhamnetin A Short Review." International Journal of Trend in Scientific Research and Development 1, no. 4 (2017): 672–78. https://doi.org/10.31142/ijtsrd2202.

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Isorhamnetin 30 Methoxy 3, 40, 5, 7 tetrahydroxyflavone is a flavonol, and it belongs to a group of plant secondary metabolites known as flavonoids. It is present in man's daily diet and is known for its biological activities such as antioxidant, antiviral, anticancer, antimicrobial, and anti inflammatory effects. Isorhamnetin has been reported for its antioxidant and antiviral applications hence it is not only used as such, but it also has various derivatized forms which has potentials for development into drugs for the treatment of diseases caused by oxidative stress and lethal viruses.

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Popiolek-Kalisz, Joanna, and Emilia Fornal. "Dietary Isorhamnetin Intake Is Inversely Associated with Coronary Artery Disease Occurrence in Polish Adults." International Journal of Environmental Research and Public Health 19, no. 19 (2022): 12546. http://dx.doi.org/10.3390/ijerph191912546.

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The role of antioxidative agents in coronary artery disease (CAD) has been investigated, but the analysis of specific flavonols intake in Polish adults requires validated tools. The aim of this study was to estimate the dietary intake of flavonols in CAD patients by creating a food frequency questionnaire (FFQ) dedicated for this purpose in Polish adults. The FFQ included 140 products from 12 food groups. The study involved 103 adult respondents (43 CAD patients and 60 healthy controls). Mean daily intakes of total flavonols, quercetin, kaempferol, myricetin and isorhamnetin were calculated as

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Kuo, I. fan, Jie Chen, and Thomas K. H. Chang. "Effect of Ginkgo biloba extract on rat hepatic microsomal CYP1A activity: role of ginkgolides, bilobalide, and flavonols." Canadian Journal of Physiology and Pharmacology 82, no. 1 (2004): 57–64. http://dx.doi.org/10.1139/y03-133.

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The present study investigated the in vitro effect of Ginkgo biloba extracts and some of the individual constituents (ginkgolides, bilobalide, and flavonols such as kaempferol, quercetin, isorhamnetin, and their glycosides) on CYP1A-mediated 7-ethoxyresorufin O-dealkylation in hepatic microsomes isolated from rats induced with β-naphthoflavone. G. biloba extract competitively inhibited CYP1A activity, with an apparent Ki value of 1.6 ± 0.4 µg/mL (mean ± SE). At the concentrations present in the G. biloba extracts, ginkgolides A, B, C, and J and bilobalide did not affect CYP1A activity, whereas

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Radenković, Nikola, Dejan Milenković, Danijela Nikodijević, Sofija Jovanović Stojanov, Ana Podolski Renić, and Milena Milutinović. "Isorhamnetin Modulates Drug-Resistance-Related Biomarkers in Colon Cancer Cells." International Journal of Molecular Sciences 26, no. 13 (2025): 6208. https://doi.org/10.3390/ijms26136208.

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The development of resistance to standard cytostatics, such as 5-fluorouracil (5-FU), significantly limits the efficacy of colon cancer therapy, prompting the search for novel anticancer agents, particularly among natural compounds. This study evaluated the anticancer effects of isorhamnetin, a plant-derived flavonol, and its ability to modulate the expression of drug-resistance-related biomarkers in SW-480 and HT-29 colon cancer cells, with a focus on ATP-binding cassette (ABC) transporters. Isorhamnetin demonstrated strong cytotoxic and proapoptotic activity on both cell lines, while showing

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Kandakumar, S., and Dr V. Manju. "Pharmacological Applications of Isorhamnetin: A Short Review." International Journal of Trend in Scientific Research and Development Volume-1, Issue-4 (2017): 672–78. http://dx.doi.org/10.31142/ijtsrd2202.

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Chirumbolo, Salvatore. "Anti-Inflammatory Action of Isorhamnetin." Inflammation 37, no. 4 (2014): 1200–1201. http://dx.doi.org/10.1007/s10753-014-9846-9.

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Ganbold, Munkhzul, Pakavarin Louphrasitthiphol, Yoshihiro Miyazaki, Tatsuya Oda, Kenichi Tominaga, and Hiroko Isoda. "Abstract C068: Isorhamnetin restricts cancer-associated fibroblasts (CAFs) phenotypic plasticity, poising them towards tumor-restraining myCAFs: Potential use of isorhamnetin as neoadjuvant in pancreatic ductal adenocarcinoma (PDAC)." Cancer Research 82, no. 22_Supplement (2022): C068. http://dx.doi.org/10.1158/1538-7445.panca22-c068.

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Abstract Pancreatic ductal adenocarcinoma (PDAC) is the deadliest cancer due lack of early diagnosis and inherent refractory to traditional chemo- and even novel immune-therapies. PDAC is marked by its extensive desmoplastic stroma containing extracellular matrix (ECM), vasculature and most importantly cancer-associated fibroblasts (CAFs). CAFs that exist in heterogenous subtypes are responsible for shaping PDAC tumor microenvironment being the main source of: ECM deposition leading up to desmoplasia that hampers the efficacy of various therapeutics, as well as diverse cytokines and growth fac

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Iwashina, Tsukasa, Minoru N. Tamura, Yoshinori Murai, and Junichi Kitajima. "New Flavonol Glycosides from the Leaves of Triantha Japonica and Tofieldia Nuda." Natural Product Communications 8, no. 9 (2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800917.

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Two new flavonol glycosides were isolated from the leaves of Triantha japonica, together with eight known flavonols, kaempferol 3- O-sophoroside, kaempferol 3- O-sambubioside, kaempferol 3- O-glucosyl-(1→2)-[glucosyl-(1→6)-glucoside], quercetin 3- O-sophoroside, quercetin 3- O-sambubioside, isorhamnetin 3- O-glucoside, isorhamnetin 3- O-sophoroside and isorhamnetin 3- O-sambubioside. The new compounds were identified as kaempferol 3- O-β-xylopyranosyl-(1→2)-[β-glucopyranosyl-(1→6)-β-glucopyranoside] (1) and isorhamnetin 3- O-β-xylopyranosyl-(1→2)-[β-glucopyranosyl-(1→6)-β-glucopyranoside] (3)

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Liu, Ning, Jiao Feng, Xiya Lu та ін. "Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways". Mediators of Inflammation 2019 (31 липня 2019): 1–14. http://dx.doi.org/10.1155/2019/6175091.

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Objective. Liver fibrosis is a consequence of wound-healing responses to chronic liver insult and may progress to liver cirrhosis if not controlled. This study investigated the protection against liver fibrosis by isorhamnetin. Methods. Mouse models of hepatic fibrosis were established by intraperitoneal injection of carbon tetrachloride (CCl4) or bile duct ligation (BDL). Isorhamnetin 10 or 30 mg/kg was administered by gavage 5 days per week for 8 weeks in the CCl4 model and for 2 weeks in the BDL model. Protein and mRNA expressions were assayed by western blotting, immunohistochemistry, and

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Xu, Sherry L., Roy C. Y. Choi, Kevin Y. Zhu, et al. "Isorhamnetin, A Flavonol Aglycone fromGinkgo bilobaL., Induces Neuronal Differentiation of Cultured PC12 Cells: Potentiating the Effect of Nerve Growth Factor." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/278273.

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Flavonoids, a group of compounds mainly derived from vegetables and herbal medicines, share a chemical resemblance to estrogen, and indeed some of which have been used as estrogen substitutes. In searching for possible functions of flavonoids, the neuroprotective effect in brain could lead to novel treatment, or prevention, for neurodegenerative diseases. Here, different subclasses of flavonoids were analyzed for its inductive role in neurite outgrowth of cultured PC12 cells. Amongst the tested flavonoids, a flavonol aglycone, isorhamnetin that was isolated mainly from the leaves ofGinkgo bilo

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Wei, Pei-Cih, Guey-Jen Lee-Chen, Chiung-Mei Chen, Ying Chen, Yen-Shi Lo та Kuo-Hsuan Chang. "Isorhamnetin Attenuated the Release of Interleukin-6 from β-Amyloid-Activated Microglia and Mitigated Interleukin-6-Mediated Neurotoxicity". Oxidative Medicine and Cellular Longevity 2022 (15 вересня 2022): 1–15. http://dx.doi.org/10.1155/2022/3652402.

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Alzheimer’s disease (AD), characterized by the abnormal accumulation of β-amyloid (Aβ), is the most prevalent type of dementia, and it is associated with progressive cognitive decline and memory loss. Aβ accumulation activates microglia, which secrete proinflammatory factors associated with Aβ clearance impairment and cause neurotoxicity, generating a vicious cycle among Aβ accumulation, activated microglia, and proinflammatory factors. Blocking this cycle can be a therapeutic strategy for AD. Using Aβ-activated HMC3 microglial cells, we observed that isorhamnetin, a main constituent of Oenant

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Okoko, Tebekeme, Faith O. Robert, and Tolulope O. Alade. "The Chemo-preventive Ability of Quercetin and Isorhamnetin on Bromate- induced Cytotoxicity and Oxidative Stress May Involve Modulation of the Inflammatory Response." Nigerian Journal of Biochemistry and Molecular Biology 39, no. 2 (2024): 57–63. http://dx.doi.org/10.4314/njbmb.v39i2.4.

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The protective/preventive effects of quercetin and isorhamnetin on bromate-induced aberrations were studied. Cells were first incubated with either quercetin or isorhamnetin before exposure to bromate. Subsequently, cell viability and production of reactive oxygen species (ROS) were assessed. In the other investigation, U937-derived macrophages were incubated with either flavonoid before exposure to bromate. Subsequently, the production of pro-inflammatory markers and expression of the antioxidant enzymes; superoxide dismutase (SOD) and catalase (CAT) were also investigated. The findings revea

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Ekstrand, Bo, Martin Krøyer Rasmussen, Felicia Woll, Vladimir Zlabek, and Galia Zamaratskaia. "In VitroGender-Dependent Inhibition of Porcine Cytochrome P450 Activity by Selected Flavonoids and Phenolic Acids." BioMed Research International 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/387918.

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We investigated gender-related differences in the ability of selected flavonoids and phenolic compounds to modify porcine hepatic CYP450-dependent activity. Using pools of microsomes from male and female pigs, the inhibition of the CYP families 1A, 2A, 2E1, and 3A was determined. The specific CYP activities were measured in the presence of the following selected compounds: rutin, myricetin, quercetin, isorhamnetin,p-coumaric acid, gallic acid, and caffeic acid. We determined that myricetin and isorhamnetin competitively inhibited porcine CYP1A activity in the microsomes from both male and fema

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Chung, Ha Sook. "Antiproliferative Activity of Allium monanthum in HT-29 Human Colorectal Adenocarcinoma Cells." Korean Tea Society 28, no. 3 (2022): 22–32. http://dx.doi.org/10.29225/jkts.2022.28.3.22.

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This study was designed to identify the phytochemicals of Allium monanthum with antiproliferative effect on HT-29 human colorectal adenocarcinoma cells through the activity-guided fractionation and isolation method. In particular, compounds 1-8 were isolated from A. monanthum, and determined to be apigenin (1), isorhamnetin (2), 5,7,3′,4′-tetrahydroxy-3-methoxyflavone (3), luteolin (4), myricetin (5), isorhamnetin-3-O-β-D-glucoside (6), isorhamnetin-3-O-β-D-rutinoside (7), and luteolin-7-O-β-D-glucoside (8) by comparing the 1D-, 2D-NMR, and ESI-MS spectral data. Of these, compound 5 significan

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Zaki Rashed, Khaled Nabih. "Biological Activities of Isorhamnetin: A Review." Plantae Scientia 3, no. 5 (2020): 78–81. http://dx.doi.org/10.32439/ps.v3i5.78-81.

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In recentyears, flavonols have been a focus of research due to their important biological activities.Isorhamnetinis a flavonol. It belongs to a group of plant secondary metabolites known as flavonoids. It is present in man’s daily diet and is known for its biological activities such as antioxidant, antiviral, anticancer, antimicrobial, anti-Tuberculosis and anti-inflammatory effects. It has been reported for its antioxidant and antiviral applications hence it is not only used as such, but it also has various derivatized forms which has potentials for development into drugs for the treatment of

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Marco, J. Alberto, J. Adell, O. Barbera, D. Strack, and V. Wray. "Two isorhamnetin triglycosides from Anthyllis sericea." Phytochemistry 28, no. 5 (1989): 1513–16. http://dx.doi.org/10.1016/s0031-9422(00)97777-x.

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Singh, K. N., and V. B. Pandey. "Isorhamnetin 7-glucoside from cnicus wallichi." Phytochemistry 25, no. 11 (1986): 2683. http://dx.doi.org/10.1016/s0031-9422(00)84544-6.

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Ku, Sae-Kwang, Tae Hoon Kim, and Jong-Sup Bae. "Anticoagulant activities of persicarin and isorhamnetin." Vascular Pharmacology 58, no. 4 (2013): 272–79. http://dx.doi.org/10.1016/j.vph.2013.01.005.

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Gong, Gang, Ying-Yun Guan, Zhong-Lin Zhang, et al. "Isorhamnetin: A review of pharmacological effects." Biomedicine & Pharmacotherapy 128 (August 2020): 110301. http://dx.doi.org/10.1016/j.biopha.2020.110301.

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Dahia, Mostefa, Laura Siracusa, Hocine Laouer, and Giuseppe Ruberto. "Constituents of the Polar Extracts from Algerian Pituranthos scoparius." Natural Product Communications 4, no. 12 (2009): 1934578X0900401. http://dx.doi.org/10.1177/1934578x0900401216.

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The methanolic and aqueous extracts of Pituranthos scoparius (Coss. & Dur.) Benth. & Hook. (Apiaceae) have been analyzed and fifteen metabolites were identified: two cinnamic acids (5-O-caffeoyl quinic acid and 5-feruloyl quinic acid), and thirteen known flavonoids (vicenin-2, six quercetin and six isorhamnetin O-glycosylated derivatives). 5-O-caffeoylquinic acid was the main component, while, of the flavonoids, the isorhamnetin derivatives were present to a greater extent.

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Stainer, Alexander R., Parvathy Sasikumar, Alexander P. Bye, et al. "The Metabolites of the Dietary Flavonoid Quercetin Possess Potent Antithrombotic Activity, and Interact with Aspirin to Enhance Antiplatelet Effects." TH Open 03, no. 03 (2019): e244-e258. http://dx.doi.org/10.1055/s-0039-1694028.

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AbstractQuercetin, a dietary flavonoid, has been reported to possess antiplatelet activity. However, its extensive metabolism following ingestion has resulted in difficulty elucidating precise mechanisms of action. In this study, we aimed to characterize the antiplatelet mechanisms of two methylated metabolites of quercetin—isorhamnetin and tamarixetin—and explore potential interactions with aspirin. Isorhamnetin and tamarixetin inhibited human platelet aggregation, and suppressed activatory processes including granule secretion, integrin αIIbβ3 function, calcium mobilization, and spleen tyros

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Ogunyemi, Babatunde T. "Quantum chemical insights into the antioxidant mechanisms of luteolin and isorhamnetin: Elucidating structure-reactivity relationships, pharmacokinetics, and toxicity for therapeutic potential." Communication in Physical Sciences 12, no. 2 (2025): 1081–93. https://doi.org/10.4314/cps.v12i2.29.

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This study presents a comprehensive computational evaluation of the antioxidant properties, physicochemical characteristics, pharmacokinetics, and toxicity profiles of two naturally occurring flavonoids—luteolin and isorhamnetin. Using quantum chemical descriptors and density functional theory (DFT) at the B3LYP/6-31G(d,p) level, we assessed the bond dissociation enthalpy (BDE), adiabatic ionization potential (AIP), proton dissociation enthalpy (PDE), proton affinity (PA), and electron transfer enthalpy (ETE) of both compounds. Isorhamnetin demonstrated superior antioxidant potential, with low

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Gu, Qiuya, Guoliang Duan, and Xiaobin Yu. "Bioconversion of Flavonoid Glycosides from Hippophae rhamnoides Leaves into Flavonoid Aglycones by Eurotium amstelodami." Microorganisms 7, no. 5 (2019): 122. http://dx.doi.org/10.3390/microorganisms7050122.

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The flowering process has been reported to play crucial roles in improving the flavor and efficacy of fermented tea. Hippophae rhamnoides leaves containing many beneficial ingredients are a suitable plant source for tea processing. In this study, we isolated a β-glucosidase-producing fungus Eurotium amstelodami BSX001 from the fermented tea and used Hippophae rhamnoides leaves (HRL) as a substrate to explore the detailed process of bioconversion of some important functional factors. The results show that the contents of total phenolic compounds and flavonoids increased significantly after seve

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