Relevant bibliographies by topics / Isotopic Labeling of Biotherapeutics

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  2. Dissertations / Theses
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Academic literature on the topic 'Isotopic Labeling of Biotherapeutics'

Author: Grafiati
Published: 7 June 2025
Last updated: 2 August 2025

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Journal articles on the topic "Isotopic Labeling of Biotherapeutics"

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Fan, Yao-Yun, Vahid Farrokhi, Teresa Caiazzo, Mengmeng Wang, Denise M. O’Hara, and Hendrik Neubert. "Human FcRn Tissue Expression Profile and Half-Life in PBMCs." Biomolecules 9, no. 8 (2019): 373. http://dx.doi.org/10.3390/biom9080373.

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System-wide quantitative characterization of human neonatal Fc receptor (FcRn) properties is critical for understanding and predicting human PK (pharmacokinetics) as well as the distribution of mAbs and Fc-fusion proteins using PBPK (physiologically-based pharmacokinetic) modeling. To this end, tissue-specific FcRn expression and half-life are important model inputs. Herein, human FcRn tissue expression was measured by peptide immunoaffinity chromatography coupled with high-resolution mass spectrometry. FcRn concentrations across 14 human tissues ranged from low to 230 pmol per gram of tissue.
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Gevaert, Kris, Francis Impens, Bart Ghesquière, Petra Van Damme, Anja Lambrechts, and Joël Vandekerckhove. "Stable isotopic labeling in proteomics." PROTEOMICS 8, no. 23-24 (2008): 4873–85. http://dx.doi.org/10.1002/pmic.200800421.

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Romsdahl, Trevor B., Shrikaar Kambhampati, Somnath Koley, et al. "Analyzing Mass Spectrometry Imaging Data of 13C-Labeled Phospholipids in Camelina sativa and Thlaspi arvense (Pennycress) Embryos." Metabolites 11, no. 3 (2021): 148. http://dx.doi.org/10.3390/metabo11030148.

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The combination of 13C-isotopic labeling and mass spectrometry imaging (MSI) offers an approach to analyze metabolic flux in situ. However, combining isotopic labeling and MSI presents technical challenges ranging from sample preparation, label incorporation, data collection, and analysis. Isotopic labeling and MSI individually create large, complex data sets, and this is compounded when both methods are combined. Therefore, analyzing isotopically labeled MSI data requires streamlined procedures to support biologically meaningful interpretations. Using currently available software and techniqu
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Reis, Mariza Gomes, Rodrigo Bibiloni, Paul McJarrow, et al. "Isotopic labeling of milk disialogangliosides (GD3)." Chemistry and Physics of Lipids 200 (October 2016): 104–12. http://dx.doi.org/10.1016/j.chemphyslip.2016.08.003.

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Paine, John B., Yezdi B. Pithawalla, John D. Naworal, and Charles E. Thomas. "Carbohydrate pyrolysis mechanisms from isotopic labeling." Journal of Analytical and Applied Pyrolysis 80, no. 2 (2007): 297–311. http://dx.doi.org/10.1016/j.jaap.2007.03.007.

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Paine, John B., Yezdi B. Pithawalla, and John D. Naworal. "Carbohydrate pyrolysis mechanisms from isotopic labeling." Journal of Analytical and Applied Pyrolysis 82, no. 1 (2008): 42–69. http://dx.doi.org/10.1016/j.jaap.2007.12.005.

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Paine, John B., Yezdi B. Pithawalla, and John D. Naworal. "Carbohydrate pyrolysis mechanisms from isotopic labeling." Journal of Analytical and Applied Pyrolysis 82, no. 1 (2008): 10–41. http://dx.doi.org/10.1016/j.jaap.2008.01.002.

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Paine, John B., Yezdi B. Pithawalla, and John D. Naworal. "Carbohydrate pyrolysis mechanisms from isotopic labeling." Journal of Analytical and Applied Pyrolysis 83, no. 1 (2008): 37–63. http://dx.doi.org/10.1016/j.jaap.2008.05.008.

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Charron, Craig S., Steven J. Britz, Roman M. Mirecki, Dawn J. Harrison, Beverly A. Clevidence, and Janet A. Novotny. "Isotopic Labeling of Red Cabbage Anthocyanins with Atmospheric 13CO2." Journal of the American Society for Horticultural Science 133, no. 3 (2008): 351–59. http://dx.doi.org/10.21273/jashs.133.3.351.

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Isotopic labeling of plants provides a unique opportunity for understanding metabolic processes. A significant challenge of isotopic labeling during plant growth is that isotopes must be administered without disrupting plant development and at sufficient levels for mass spectral analysis. We describe a system for isotopic labeling of leafy vegetables with 13C and demonstrate successful incorporation of 13C into anthocyanins of preheading red cabbage (Brassica oleracea L. var. capitata L.). ‘Super Red’ red cabbage seedlings were grown for 34 days in an airtight acrylic labeling chamber supplied
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Miller, Benjamin F., Christopher A. Wolff, Fredrick F. Peelor, Patrick D. Shipman, and Karyn L. Hamilton. "Modeling the contribution of individual proteins to mixed skeletal muscle protein synthetic rates over increasing periods of label incorporation." Journal of Applied Physiology 118, no. 6 (2015): 655–61. http://dx.doi.org/10.1152/japplphysiol.00987.2014.

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Advances in stable isotope approaches, primarily the use of deuterium oxide (2H2O), allow for long-term measurements of protein synthesis, as well as the contribution of individual proteins to tissue measured protein synthesis rates. Here, we determined the influence of individual protein synthetic rates, individual protein content, and time of isotopic labeling on the measured synthesis rate of skeletal muscle proteins. To this end, we developed a mathematical model, applied the model to an established data set collected in vivo, and, to experimentally test the impact of different isotopic la
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Dissertations / Theses on the topic "Isotopic Labeling of Biotherapeutics"

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Jagdeo, Julienne. "Identification of novel picornavirus proteinase substrates using terminal amine isotopic labeling of substrates." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/61277.

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Viruses have exploited strategies of proteolysis for the purposes of processing viral proteins and manipulating cellular processes to direct synthesis of new virions and subvert host antiviral responses. Many viruses encode proteases within their genome, of which many have been well studied among the family of positive-sense single-stranded RNA picornaviruses. A subset of host proteins have already been identified as targets of picornaviral proteinases; however, the full repertoire of targets is not known. In this thesis, a novel proteomics-based approach termed terminal amine isotopic labelin
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Dean, Matthew, Geoffrey Findlay, Michael Hoopmann, et al. "Identification of ejaculated proteins in the house mouse (Mus domesticus) via isotopic labeling." BioMed Central, 2011. http://hdl.handle.net/10150/610018.

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BACKGROUND:Seminal fluid plays an important role in successful fertilization, but knowledge of the full suite of proteins transferred from males to females during copulation is incomplete. The list of ejaculated proteins remains particularly scant in one of the best-studied mammalian systems, the house mouse (Mus domesticus), where artificial ejaculation techniques have proven inadequate. Here we investigate an alternative method for identifying ejaculated proteins, by isotopically labeling females with 15N and then mating them to unlabeled, vasectomized males. Proteins were then isolated from
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Jiang, Lin. "Mechanisms of Chloroperoxidase-catalyzed Enantioselective Reactions as Probed by Site-directed Mutagenesis and Isotopic Labeling." FIU Digital Commons, 2012. http://digitalcommons.fiu.edu/etd/774.

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Chloroperoxidase (CPO) is a heme-containing glycoprotein secreted by the marine fungus Caldariomyces fumago. Chloroperoxidase contains one ferriprotoporphyrin IX prosthetic group per molecule and catalyzes a variety of reactions, such as halogenation, peroxidation and epoxidation. The versatile catalytic activities of CPO coupled with the increasing demands for chiral synthesis have attracted an escalating interest in understanding the mechanistic and structural properties of this enzyme. In order to better understand the mechanisms of CPO-catalyzed enantioselective reactions and to fine-tune
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Barra, Lena [Verfasser]. "Studies on the Biosynthesis and Structure Elucidation of Terpene Natural Products by Isotopic Labeling Experiments / Lena Barra." Bonn : Universitäts- und Landesbibliothek Bonn, 2019. http://d-nb.info/1177881667/34.

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Waldecker, Bernd. "Investigations towards the design, synthesis and application of new sulfur-based transfer reagents." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2019. http://hdl.handle.net/21.11130/00-1735-0000-0003-C138-4.

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Daou, Fatma. "Etude expérimentale d'un procédé de dépollution par décharge couronne à barrière diélectrique type pointe(s) - plan : rôle de la simulation numérique et du marquage isotopique." Paris 6, 2002. http://www.theses.fr/2002PA066488.

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Lenoir-Capello, Rachel. "Specific labeling strategies for new developments in liquid state protein NMR." Thesis, Sorbonne université, 2020. https://accesdistant.sorbonne-universite.fr/login?url=http://theses-intra.upmc.fr/modules/resources/download/theses/2020SORUS056.pdf.

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La résonance magnétique nucléaire (RMN) fournit des informations structurelles et dynamiques précieuses à l'échelle atomique, cependant, la faible sensibilité et résolution des signaux empêchent l’étude d'objets moléculaires plus importants. Nous présentons 3 stratégies de marquage isotopique pour différentes expériences RMN des protéines en solution et démontrons leur potentiel pour l'étude structurale des biomolécules. Parmi les stratégies envisagées, 2 utilisent l'expression in vitro pour obtenir des protéines marquées sélectivement sur un groupe chimique et/ou acide aminé dans un environne
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Gao, Longhui. "C-H bond activation catalyzed by Ruthenium nanoparticles." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS348/document.

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Les molécules marquées par des isotopes de l’hydrogène possèdent de nombreuses applications dans divers domaines tels que la chimie, la biologie ou en science des matériaux. Dans le domaine de la recherche de nouveaux médicaments, les études liées à la pharmacocinétique nécessitent un accès rapide à des molécules marquées afin de ne pas impacter les coûts et les délais de développement. Le développement de la métabolomique a aussi entrainé une augmentation du besoin en molécules marquées isotopiquement. En effet, les molécules deuterées peuvent être utilisées en tant qu’étalons internes pour l
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Yan, Zhiqing. "Theoretical and Experimental Studies of the Lithiation of Cyclic Vinyl Ethers in Gas Phase and Ethereal Solutions." Miami University / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=miami1091024241.

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Kim, Kilsun. "Investigations of Electronic Cigarette Chemistry: 1. Formation Pathways for Degradation Products Using Isotopic Labeling; and 2. Gas/Particle Partitioning of Nicotine and Flavor Related Chemicals in Electronic Cigarette Fluids." PDXScholar, 2017. https://pdxscholar.library.pdx.edu/open_access_etds/3944.

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Use of electronic cigarettes (e-cigarettes) is rapidly growing around the world. E-cigarettes are commonly used as an alternative nicotine delivery system, and have been advocated as generating lower levels of harmful chemicals compared to conventional cigarettes. Cigarette smoke-like aerosols are generated when e-cigarettes heat e-liquids. The main components of e-cigarette liquids are propylene glycol (PG) and glycerol (GL) in a varying ratio, plus nicotine and flavor chemicals. Both PG and GL are considered safe to ingest in foods and beverages, but the toxicity of these chemicals in aeroso
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Books on the topic "Isotopic Labeling of Biotherapeutics"

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Analysis of LDEF experiment AO187-2 chemical and isotopic measurements of micrometeoroids by secondary ion mass spectrometry: Final report NAG1-1174 to the National Aeronautics and Space Administration ; principal investigator, Ernst Zinner. The Administration, 1995.

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Book chapters on the topic "Isotopic Labeling of Biotherapeutics"

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Ashman, Keith, María Isabel Ruppen Cañás, Jose L. Luque-Garcia, and Fernando García Martínez. "Stable Isotopic Labeling for Proteomics." In Sample Preparation in Biological Mass Spectrometry. Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-0828-0_27.

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Sperry, Justin B., and Lisa M. Jones. "Utilization of Chemical Labeling and Mass Spectrometry for the Biophysical Characterization of Biopharmaceuticals." In Biophysical Methods for Biotherapeutics. John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118354698.ch6.

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Andersen, Jakob L., Daniel Merkle, and Peter S. Rasmussen. "Graph Transformations, Semigroups, and Isotopic Labeling." In Bioinformatics Research and Applications. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-20242-2_17.

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Dunbar, Bonnie S. "Isotopic Labeling of Proteins for Electrophoretic Analysis." In Two-Dimensional Electrophoresis and Immunological Techniques. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-1957-3_6.

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Price, John C., and Sina Ghaemmaghami. "Analysis of Proteome Dynamics in Mice by Isotopic Labeling." In Shotgun Proteomics. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0685-7_7.

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Seim, Gretchen L., Emily C. Britt, and Jing Fan. "Analysis of Arginine Metabolism Using LC-MS and Isotopic Labeling." In High-Throughput Metabolomics. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9236-2_13.

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Whittaker, James W. "Selective Isotopic Labeling of Recombinant Proteins Using Amino Acid Auxotroph Strains." In Methods in Molecular Biology. Humana Press, 2007. http://dx.doi.org/10.1007/978-1-59745-456-8_13.

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Roy, Sushmita Mimi, and Christopher H. Becker. "Quantification of Proteins and Metabolites by Mass Spectrometry Without Isotopic Labeling." In Methods in Molecular Biology. Humana Press, 2007. http://dx.doi.org/10.1007/978-1-59745-255-7_6.

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Lund, Peder J., Yekaterina Kori, Xiaolu Zhao, Simone Sidoli, Zuo-Fei Yuan, and Benjamin A. Garcia. "Isotopic Labeling and Quantitative Proteomics of Acetylation on Histones and Beyond." In Methods in Molecular Biology. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9232-4_5.

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Liu, Dongsheng, and David Cowburn. "Segmental Isotopic Labeling of Proteins for NMR Study Using Intein Technology." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6451-2_9.

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Conference papers on the topic "Isotopic Labeling of Biotherapeutics"

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Lakhani, Ahmed, Anjan Roy, Marcelo Nakaema, et al. "Raman Scattering Investigation of 3[sub 10] Helical Peptides Using Isotopic Labeling." In XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY. AIP, 2010. http://dx.doi.org/10.1063/1.3482740.

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Norrman, Kion, and Frederik C. Krebs. "Chemical degradation mechanisms of organic photovoltaics studied by TOF-SIMS and isotopic labeling." In Optics & Photonics 2005, edited by Zakya H. Kafafi and Paul A. Lane. SPIE, 2005. http://dx.doi.org/10.1117/12.613433.

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Chi, Heng, Ahmed Lakhani, Anjan Roy, et al. "Inter-Residue Coupling of Model PPII Helices Using [sup 13]C Isotopic Labeling Investigated by Vibrational Spectroscopy." In XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY. AIP, 2010. http://dx.doi.org/10.1063/1.3482720.

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Daou, F., A. Vincent, and Jacques Amouroux. "REMOVAL OF NITRIC OXIDE IN VEHICLE EXHAUST GAS BY MULTIPOINTS TO PLANE DIELECTRIC BARRIER DISCHARGE: UNDERSTANDING OF THE REACTION PATHWAY BY ISOTOPIC LABELING." In Progress in Plasma Processing of Materials, 2003. Begellhouse, 2023. http://dx.doi.org/10.1615/itppc-2002.800.

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Reports on the topic "Isotopic Labeling of Biotherapeutics"

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Chapple, Clint, and Brian Dilkes. Final Technical Report for Coupling Metabolic Source Isotopic Pair Labeling and Genome Wide Association for Metabolite and Gene Annotation in Plants. Office of Scientific and Technical Information (OSTI), 2024. https://doi.org/10.2172/2480709.

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Kim, Kilsun. Investigations of Electronic Cigarette Chemistry: 1. Formation Pathways for Degradation Products using Isotopic Labeling; and 2. Gas/Particle Partitioning of Nicotine and Flavor Related Chemicals in Electronic Cigarette Fluids. Portland State University Library, 2000. http://dx.doi.org/10.15760/etd.5828.

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