Academic literature on the topic 'Isoxazole derivatives'

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Journal articles on the topic "Isoxazole derivatives"

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V S, Anila Kumari, Dr Prasobh G R, and Sheeja Rekha A G. "A Brief Review on Isoxazole Derivatives as Antibacterial Agents." International Journal of Research and Review 9, no. 9 (2022): 321–33. http://dx.doi.org/10.52403/ijrr.20220935.

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Isoxazole compounds exhibit a wide spectrum of targets and broad biological activities. Isoxazole derivatives are still popular scaffolds for the development of new agents with variable biological activities such as antimicrobial, antiviral, anticancer, anti-inflammatory, immunomodulatory, anticonvulsant or antidiabetic properties. The key feature of these heterocycles is that they possess the typical properties of an aromatic system but contain a weak nitrogen-oxygen bond which under certain reaction conditions like reducing or basic conditions is a potential site of ring cleavage. Thus, isox
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Ouzounthanasis, Konstantinos A., Jasmina Glamočlija, Ana Ćirić, and Alexandros E. Koumbis. "Studies of the Synthesis of Fused Isoxazoline/Isoquinolinones and Evaluation of the Antifungal Activity of Isoxazole-like Benzamide and Isoquinolinone Hybrids." Molecules 30, no. 3 (2025): 589. https://doi.org/10.3390/molecules30030589.

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Isoxazole derivatives (isoxazoles, isoxazolines, and isoxazolidines) are present in the structure of several natural products and/or pharmaceutically interesting compounds. In this work, a synthetic study for the preparation of fused isoxazoline/isoquinolinone hybrids is presented. The initial approach involving the sequential 1,3-dipolar cycloaddition of nitrile oxides to indenone (to obtain the isoxazoline ring) and a Beckmann rearrangement (to construct the isoquinolinone lactam system) was complicated by the formation of fragmentation products during the latter. Therefore, the desired hybr
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Subi, S., S. Viola Rose, and T. F. Abbs Fen Reji. "Synthesis, Characterization, DFT Study, Molecular Modelling and Biological Evaluation of Novel 5-Aryl-3-(pyridine-3-yl)isoxazole Hybrids as Potent Anticancer Agents with Inhibitory Effect on Skin Cancer." Asian Journal of Chemistry 33, no. 10 (2021): 2281–86. http://dx.doi.org/10.14233/ajchem.2021.23335.

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A novel series of pyridinyl isoxazole derivatives was synthesized and characterized by IR, 1H and 13C NMR and high-resolution mass spectrometry. Geometrical and electronic properties of pyridinyl isoxazole derivative was investigated by using B3LYP/6-31G (d,p) basis sets. The HOMO and LUMO analysis was used to determine the charge transfer within the molecule. The pyridinyl isoxazole derivatives exhibited good docking scores against liver cancer 4MMH. The results revealed clearly compound 2b exhibited better radical scavenging ability. Among the synthesized pyridinyl isoxazole derivatives, com
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Wang, Haoyu, Yurui Ma, Yifan Lin, et al. "An Isoxazole Derivative SHU00238 Suppresses Colorectal Cancer Growth through miRNAs Regulation." Molecules 24, no. 12 (2019): 2335. http://dx.doi.org/10.3390/molecules24122335.

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Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Isoxazoline and isoxazole derivatives represent an important class of five-membered heterocycles, which play a pivotal role in drug discovery. In our previous study, we developed a series of isoxazole derivatives with an efficient method. In this study, we evaluated their effects on tumor cell growth. HCT116 cells were treated with isoxazole derivatives; an cholecystokinin octapeptide (CCK-8) assay was used to calculate the IC50 (half maximal inhibitory concentration) of each derivative. Compound SHU00238, which was
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Thirunarayanan, G., and V. Sathiyendiran. "Synthesis, Pharmacological and Insect Antifeedant Activities of some 3-(2-Naphthyl)-5-(Substituted Phenyl)-4,5-Dihydroisoxazoles." International Letters of Chemistry, Physics and Astronomy 49 (April 2015): 1–14. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.49.1.

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Totally thirty one 3,5-substituted aryl 4,5-dihydro isoxazole derivatives including 3-(2-naphthyl)-5-(substituted phenyl)-4,5-dihydroisoxazole have been synthesized by fly-ash:H2SO4 catalyzed cyclization of hydroxylamine hydrochloride and aryl chalcones under solvent-free conditions. The yields of the isoxazoles are more than 94%. The synthesized isoxazole were characterized by their physical constants and spectral data. The antimicrobial, antioxidant and insect antifeedant activities of the synthesized isoxazoles have been evaluated using a variety of bacterial and fungal species, DPPH radica
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Thirunarayanan, G., and V. Sathiyendiran. "Synthesis, Pharmacological and Insect Antifeedant Activities of some 3-(2-Naphthyl)-5-(Substituted Phenyl)-4,5-Dihydroisoxazoles." International Letters of Chemistry, Physics and Astronomy 49 (April 7, 2015): 1–14. http://dx.doi.org/10.56431/p-g0r04d.

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Totally thirty one 3,5-substituted aryl 4,5-dihydro isoxazole derivatives including 3-(2-naphthyl)-5-(substituted phenyl)-4,5-dihydroisoxazole have been synthesized by fly-ash:H2SO4 catalyzed cyclization of hydroxylamine hydrochloride and aryl chalcones under solvent-free conditions. The yields of the isoxazoles are more than 94%. The synthesized isoxazole were characterized by their physical constants and spectral data. The antimicrobial, antioxidant and insect antifeedant activities of the synthesized isoxazoles have been evaluated using a variety of bacterial and fungal species, DPPH radica
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Arshad, Nasima, Yasir Mehmood, Hammad Ismail, et al. "Newly synthesized sulfonamide derivatives explored for DNA binding, enzyme inhibitory, and cytotoxicity activities: a mixed computational and experimental analyses." RSC Advances 14, no. 47 (2024): 35047–63. http://dx.doi.org/10.1039/d4ra06412g.

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This work reports synthesis, characterization, DNA, enzyme binding and cytotoxicity activity of three 4-((3-arylthiazolo[3,4-d]isoxazol-5-yl)amino)benzene sulfonamide derivatives with a thaizaole(3,4-d)isoxazole-based fused ring heterocyclic system.
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Sharma, Aruna, Anjali Yadav, Hardik Pathak, Bhawana Jangir, and Rahul Goel. "Effective synthesis and pharmacological evaluation of 1,2,4-triazolo-isoxazole and 1,2,4-triazolo-pyrazole scaffolds." Research Journal of Chemistry and Environment 29, no. 5 (2025): 77–82. https://doi.org/10.25303/295rjce077082.

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Five-membered heteroaromatic compounds like pyrazoles and isoxazoles are significant for the pharmaceutical sector and material research, becoming more significant in drug research, cosmetics as well as in the creation of agricultural products. 1,2,4-triazolo fused isoxazole derivatives (3a-f) were synthesized from reaction between intermediate chal cone-1,2,4-triazolo-1,5-benzodiazepine derivatives 2af with hydroxyl amine hydrochloride. 1,2,4-triazolo fused pyrazole derivatives (3a-f and 4a-f) were prepared from reaction between chalcone derivatives 2a-f with hydrazine hydrate and its phenyl
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S. Abibindhu, Smitha Nair, and C. Kannan. "SYNTHESIS AND ANTI-INFLAMMATORY, ANTIOXIDANT STUDIES OF NOVEL CHALCONES-BASED ISOXAZOLE DERIVATIVES." RASAYAN Journal of Chemistry 15, no. 04 (2022): 2661–65. http://dx.doi.org/10.31788/rjc.2022.1547023.

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Our previous work identified various novel Chalcones (I-III) produced by mixing the equimolar amount of Ferrocene aldehyde and different substituted acetophenones which has a strong base. Hence, in the present study, novel various Chalcones (I-III) were treated with hydroxylamine hydrochloride to form various Isoxazoles (Ic-IIIc). The synthesized novel chalcone-based Isoxazole derivatives were determined by spectroscopic techniques such as1H,13C-NMR, FT-IR,and UV. Further, these products were evaluated for antimicrobial studies and antioxidant susceptibilities through DPPH radical scavenging m
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Al-Omran, Fatima, and Adel A. El-Khair. "Studies with 2-(acetonylthio)benzothiazole. New routes to isoxazoles, isoxazolo[3,4-b]pyridines, pyrazolo[1,5-a]pyrimidines, pyridines and quinolizines." Journal of Chemical Research 2009, no. 7 (2009): 433–36. http://dx.doi.org/10.3184/030823409x464412.

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Derivatives of isoxazole, isoxazolo[3,4- b]pyridine, pyrazolo-[1,5- a]pyrimidine and pyridin-2(1 H)-one incorporating a benzothiazole-2-thio residue have been synthesised. The structures of these newly synthesised compounds are characterised by elemental analysis, IR, 1H and 13C NMR, NOE and MS.
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Dissertations / Theses on the topic "Isoxazole derivatives"

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Tampieri, Alberto. "Synthesis, reactivity and applications of 3,5-dimethyl-4-nitroisoxazole derivatives." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/10014/.

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3,5-dimethyl-4-nitroisoxazole derivatives are useful synthetic intermediates as the isoxazole nucleus chemically behaves as an ester, but establish better-defined interactions with chiral catalysts and lability of its N-O aromatic bond can unveil other groups such as 1,3-dicarbonyl compounds or carboxylic acids. In the present work, these features are employed in a 3,5-dimethyl-4-nitroisoxazole based synthesis of the γ-amino acid pregabalin, a medication for the treatment of epilepsy and neuropatic pain, in which this moiety is fundamental for the enantioselective formation of a chiral center
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Aleksandar, Oklješa. "Sinteza i biološka aktivnost novih steroidnih heterocikličnih jedinjenja." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2015. https://www.cris.uns.ac.rs/record.jsf?recordId=94966&source=NDLTD&language=en.

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U ovoj doktorskoj disertaciji ispitane su 1,3-dipolarnecikloadicione reakcije steroidnih azido-nitrila, nitrona initril-oksida, pri čemu su sintetizovana različitaheterociklična steroidna jedinjenja androstanske i estranskeserije. Utvrdjene su strukture novosintetizovanihjedinjenja. Ispitana je biolo&scaron;ka aktivnost odabranihjedinjenja.<br>In this PhD thesis 1,3-dipolar cycloadditions ofsteroidal azido-nitriles, nitrones and nitrile-oxide wereexamined. Various steroidal heterocyclic compounds inthe androstane and estrane series were synthesised. Thestructural characterisation of newly synt
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Chhetri, Esmita. "Synthesis, characterization and inclusion complexation of some isoxazolidine and isoxazoline derivatives for advanced applications explored by physicochemical approach." Thesis, University of North Bengal, 2021. http://ir.nbu.ac.in/handle/123456789/4343.

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Sharma, Prawin Kumar. "Greener approach to the synthesis of some novel class of isoxazolidine and isoxazoline derivatives using N-methyl and N-phenyl-a-chloro nitrones." Thesis, University of North Bengal, 2016. http://ir.nbu.ac.in/handle/123456789/1884.

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Toh, Ophilia Ndi. "Synthesis Towards Fulminic Acid and Its Derivatives in 1, 3-Dipolar Cycloaddition Reactions." Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etd/1982.

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A new approach to fulminic acid cycloadditions has been developed. At reduced temperatures, fulminic acid is generated in situ and undergoes 1, 3-diploar cycloaddition reactions with dipolarophiles to form isoxazolines and/or its dimers. This procedure represents a novel, safe general method for the one-step generation of fulminic acid, which complements existing potentially explosive protocols.
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Luitel, Govinda Prasad. "Greener synthesis of some new isoxazolidine and isoxazoline derivatives via 1,3-dipolar cycloaddition reactions and studies of biological activities of the cycloadducts." Thesis, University of North Bengal, 2017. http://ir.nbu.ac.in/handle/123456789/2576.

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Roy, Amélie. "Synthetic studies of the formation of oxazoles and isoxazoles from N-acetoacetyl derivatives, scope and limitations ; and Aqueous rhodium-catalyzed Heck-type coupling reactions between boronic acids and olefins." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0021/MQ53366.pdf.

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TROGU, ELENA. "Synthesis of isoxazole derivatives by catalytic condensation of primary nitro compounds with dipolarophiles." Doctoral thesis, 2010. http://hdl.handle.net/2158/555297.

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Kuo, Ming-Luen, and 郭明倫. "Syntheses of Phenols and Calix[4]arenes with Isoxazoline or Isoxazole and Their Ring Opening Derivatives and Metal Ion Sensing Studies." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/75v352.

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碩士<br>國立交通大學<br>應用化學系碩博士班<br>107<br>We modified the lower rim of calix[4]arenes with isoxazoline or isoxazole to get the anthracene derivatives 18, 25a and 25b. by 1,3-dipolar cycloaddition. However, we could not synthesize the corresponding calix[4]arene derivatives with β-hydroxy-ketone or β-amino-α,β-unsaturated-ketone after trying the kinds of reaction conditions. Then we introduced the five member ring of isoxazole into phenol, o-benzenediol and m-benzenediol and successfully synthesized the β-amino-α,β-unsaturated-ketone derivatives 30, 34 and 38 by using Mo(CO)6 to carry out the ring-op
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Tsai, Shao-Ling, та 蔡韶玲. "β-Diketone, Pyrazole and Isoxazole Derivatives with Polar Groups: Liquid Crystalline and Thermodynamic Properties". Thesis, 2007. http://ndltd.ncl.edu.tw/handle/66543881468988295014.

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碩士<br>國立中央大學<br>化學研究所<br>95<br>In this serie, we report the synthesis, characterization and mesomorphic properties of two series of new mesogenic derivatives based on pyrazole and isoxazole structures. All compounds were characterized by 1H, 13C-NMR spectroscopy and elemental analysis. The phase behaviors of these mesogenic compounds were characterized and studied by differential scanning calorimeter (DSC) and polarization optical microscope. In serie one, a new type of mesogenic compounds derived from heterocyclic pyrazole and isoxazole (Iz-Cn) were prepared and studied. All compounds exhibit
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Books on the topic "Isoxazole derivatives"

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Roy, Amelie. Synthetic studies of the formation of oxazoles and isoxazoles from N-acetoacetyl derivatives: Scope and limitations AND Aqueous rhodium-catalyzed Heck-type coupling reactions between boronic acids and olefins. 2000.

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Book chapters on the topic "Isoxazole derivatives"

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Quiulico, Adolfo. "Applications of Isoxazole Derivatives." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186787.ch6.

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Speroni, Giovanni. "The Physico-Chemical Properties of Isoxazole and its Derivatives." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186787.ch5.

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De Sarlo, Francesco, and Fabrizio Machetti. "Condensation of Primary Nitro Compounds to Isoxazole Derivatives: Stoichiometric To Catalytic." In Methods and Applications of Cycloaddition Reactions in Organic Syntheses. John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118778173.ch08.

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Simoni, Daniele, Stefano Manfredini, Mojgan Aghazade Tabrizi, et al. "Synthesys of Isoxazole and Isoxazoline Derivatives of Retinoids: Effects on Growth and Differentiation of Tumor Cells." In Topics in Molecular Organization and Engineering. Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3620-4_10.

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Desai, Kishor R., and Bhavin R. Patel. "Various Synthetic Strategies and Therapeutic Potential of Thiadiazole, Oxadiazole, Isoxazole and Isothiazole Derivatives." In N-Heterocycles. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-0832-3_6.

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Gujjarappa, Raghuram, Sattu Sravani, Arup K. Kabi, et al. "An Overview on Biological Activities of Oxazole, Isoxazoles and 1,2,4-Oxadiazoles Derivatives." In Materials Horizons: From Nature to Nanomaterials. Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-8399-2_10.

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Mohan Sahoo, Biswa, Bera Venkata Varaha Ravi Kumar, Krishna Chandra Panda, et al. "Isoxazole Derivatives as Potential Pharmacophore for New Drug Development." In Frontiers in Medicinal Chemistry. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815165043123100004.

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Isoxazoles are five-membered aromatic heterocyclic compounds in which oxygen and nitrogen atoms are present at positions 1 and 2 of the ring system. Isoxazole derivatives play a vital role due to their diverse biological activities, such as antimicrobial, antifungal, anti-viral, anti-tubercular, anti-epileptic, anti-diabetic, anticancer, anthelmintic, antioxidant, antipsychotic, antimalarial, analgesic, anti-inflammatory, etc. Isoxazole scaffold is present in various drug molecules, such as leflunomide (antirheumatic), valdecoxib (non-steroidal anti-inflammatory drug), and zonisamide (anti-con
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Mohite, Popat, Savita Tauro, and Aarati Pawar. "Isoxazole." In Advances in Chemical and Materials Engineering. IGI Global, 2025. https://doi.org/10.4018/979-8-3693-7267-8.ch003.

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Isoxazole is a versatile five-membered heterocyclic compound that has attracted significant attention due to its diverse medicinal chemistry and material science applications. This chapter provides a comprehensive overview of synthetic methodologies for preparing isoxazole derivatives, including traditional approaches such as cyclization reactions and modern techniques like microwave-assisted synthesis. The advantages and limitations of each method, highlighting the influence of structural variations on synthesis efficiency, are discussed. Furthermore, the biological activities associated with
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Jaiswal, Shalini. "Aqua Mediated Multicomponent Synthesis of N, O-Heterocycles and Biological Activity of Fused Isoxazole Derivatives." In Advances in Chemical and Materials Engineering. IGI Global, 2025. https://doi.org/10.4018/979-8-3693-7267-8.ch012.

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In the literature, several Drugs substituted with isoxazole ring shows various biological activities. The various drugs available in the market like sulfamethoxazole A, muscimol-B, ibotenic acid C, parecoxib-D, and leounomide contain the core structure of isoxazole. The use of water and phase transfer catalyst combined acted as a green attribute for the current approach. The current methodology has several benefits, such as a single-pot reaction, environmental friendliness, economic viability, wide substrate range, ease of operation, quick reaction time, simple workup process, and elevated yie
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Jays, Judy, P. Parasuram, and J. Saravanan. "Screening of Some Novel Isoxazoles Against C. Albicans for their Potential Use as antifungals: A Computational Approach." In Current Trends in Drug Discovery, Development and Delivery (CTD4-2022). Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671090-00103.

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Antifungal resistance represents a major challenge for treating invasive fungal infections due to the limited arsenal of systemic antifungal agents. Azole resistance among Candida and Aspergillus species and the spread of such species is alarming. Isoxazoles play a significant role in the field of medicinal chemistry. The great interest associated with this class of compounds is their versatility as synthetic intermediates. Isoxazole derivatives were found to possess anti-bacterial, anti-fungal, anti-inflammatory, pesticidal and herbicidal activities. This study focuses on screening some novel
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Conference papers on the topic "Isoxazole derivatives"

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Silva-Alves, Diana C. B. da, Janaína V. dos Anjos, Nery N. M. Cavalcante, Daniela M. do A. F. Navarro, Geanne K. N. Santos, and Rajendra M. Srivastava. "Synthesis of new isoxazole derivatives with larvicidal activity." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0284-1.

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Vilela, G. D., R. R. da Rosa, and A. A. Merlo. "Isoxazole Derivatives With Potential Applications in Polymers and Semiconductors." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0032-1.

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Li, Xiaoting, Weijun Liu, Shouzhi Pu, and Hui Li. "Synthesis and Properties of Photochromic Diarylethene Derivatives Bearing Benzofuran and Isoxazole Units." In 2012 Symposium on Photonics and Optoelectronics (SOPO 2012). IEEE, 2012. http://dx.doi.org/10.1109/sopo.2012.6271041.

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Chikkanna, Dinesh, Anirudha Lakshminarasimhan, Vinayak Khairnar, et al. "Abstract 5367: Discovery of dihydro-isoxazole derivatives as novel inhibitors of NAMPT for the treatment of multiple myeloma." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-5367.

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Stabile, Santiago, Juan Facundo Chrestia, Gabriel Radivoy та Cecilia Bouzat. "Design, Synthesis, and Biological Assessment of Novel Vanillin-Isoxazole Derivatives as Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptor". У ECSOC 2023. MDPI, 2023. http://dx.doi.org/10.3390/ecsoc-27-16097.

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Giannini, Giuseppe, Walter Cabri, Tiziana Brunetti, et al. "Abstract 731: 4-Amino-substituted 5-resorcinol-isoxazole derivatives, a novel class of Hsp90 inhibitor: Synthesis and evaluation of in vitro activity." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-731.

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Nurjanah, N., and E. Saepudin. "Curcumin isolation, synthesis and characterization of curcumin isoxazole derivative compound." In PROCEEDINGS OF THE 4TH INTERNATIONAL SYMPOSIUM ON CURRENT PROGRESS IN MATHEMATICS AND SCIENCES (ISCPMS2018). AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5132492.

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Bharathi, R., and N. Santhi. "Synthesis, docking studies and antioxidant activity of some chalcone and isoxazoline derivatives." In EIGHTH INTERNATIONAL CONFERENCE NEW TRENDS IN THE APPLICATIONS OF DIFFERENTIAL EQUATIONS IN SCIENCES (NTADES2021). AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0076819.

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Marjanović, Đorđe, Dragana Medić, Tihomir Marić, and Saša Trailović. "Exploring potential antinematodal effects of some insecticides from isoxazoline group." In 36. Savetovanje dezinfekcija, dezinsekcija i deratizacija jedan svet - jedno zdravlje, Vrnjačka Banja, hotel "Vrnjačke Terme", 28-31.maj 2025.godine. Srpsko veterinarsko društvo, 2024. https://doi.org/10.5937/ddd25095m.

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Isoxazoline insecticides, such as fluralaner, afoxolaner, and sarolaner, are widely used for pest control in agriculture and veterinary medicine due to their effectiveness against arthropods like fleas, ticks, and mites. These compounds work by targeting GABA receptors and chloride ion channels in insects and arachnids. Recent studies, however, suggest that isoxazolines may also have potential in combating nematodes, which pose significant challenges in agriculture and human health. Nematodes, including parasitic and free-living species, can cause severe damage to crops and livestock. Isoxazol
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Soares, Ozildéia, Gabriela R. Hurtado, Luiz H. Viana, Sérgio de Albuquerque, and Adriano C. M. Baroni. "Synthesis of Isoxazolic analogues derivatives of Grandisin and Veraguensin neolignans with anti-leishmania and antitrypanosomal activities." In 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_20139410384.

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