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Dissertations / Theses on the topic 'Isoxazole derivatives'

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1

Tampieri, Alberto. "Synthesis, reactivity and applications of 3,5-dimethyl-4-nitroisoxazole derivatives." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/10014/.

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3,5-dimethyl-4-nitroisoxazole derivatives are useful synthetic intermediates as the isoxazole nucleus chemically behaves as an ester, but establish better-defined interactions with chiral catalysts and lability of its N-O aromatic bond can unveil other groups such as 1,3-dicarbonyl compounds or carboxylic acids. In the present work, these features are employed in a 3,5-dimethyl-4-nitroisoxazole based synthesis of the γ-amino acid pregabalin, a medication for the treatment of epilepsy and neuropatic pain, in which this moiety is fundamental for the enantioselective formation of a chiral center
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2

Aleksandar, Oklješa. "Sinteza i biološka aktivnost novih steroidnih heterocikličnih jedinjenja." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2015. https://www.cris.uns.ac.rs/record.jsf?recordId=94966&source=NDLTD&language=en.

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U ovoj doktorskoj disertaciji ispitane su 1,3-dipolarnecikloadicione reakcije steroidnih azido-nitrila, nitrona initril-oksida, pri čemu su sintetizovana različitaheterociklična steroidna jedinjenja androstanske i estranskeserije. Utvrdjene su strukture novosintetizovanihjedinjenja. Ispitana je biolo&scaron;ka aktivnost odabranihjedinjenja.<br>In this PhD thesis 1,3-dipolar cycloadditions ofsteroidal azido-nitriles, nitrones and nitrile-oxide wereexamined. Various steroidal heterocyclic compounds inthe androstane and estrane series were synthesised. Thestructural characterisation of newly synt
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3

Chhetri, Esmita. "Synthesis, characterization and inclusion complexation of some isoxazolidine and isoxazoline derivatives for advanced applications explored by physicochemical approach." Thesis, University of North Bengal, 2021. http://ir.nbu.ac.in/handle/123456789/4343.

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4

Sharma, Prawin Kumar. "Greener approach to the synthesis of some novel class of isoxazolidine and isoxazoline derivatives using N-methyl and N-phenyl-a-chloro nitrones." Thesis, University of North Bengal, 2016. http://ir.nbu.ac.in/handle/123456789/1884.

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5

Toh, Ophilia Ndi. "Synthesis Towards Fulminic Acid and Its Derivatives in 1, 3-Dipolar Cycloaddition Reactions." Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etd/1982.

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A new approach to fulminic acid cycloadditions has been developed. At reduced temperatures, fulminic acid is generated in situ and undergoes 1, 3-diploar cycloaddition reactions with dipolarophiles to form isoxazolines and/or its dimers. This procedure represents a novel, safe general method for the one-step generation of fulminic acid, which complements existing potentially explosive protocols.
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6

Luitel, Govinda Prasad. "Greener synthesis of some new isoxazolidine and isoxazoline derivatives via 1,3-dipolar cycloaddition reactions and studies of biological activities of the cycloadducts." Thesis, University of North Bengal, 2017. http://ir.nbu.ac.in/handle/123456789/2576.

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7

Roy, Amélie. "Synthetic studies of the formation of oxazoles and isoxazoles from N-acetoacetyl derivatives, scope and limitations ; and Aqueous rhodium-catalyzed Heck-type coupling reactions between boronic acids and olefins." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0021/MQ53366.pdf.

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8

TROGU, ELENA. "Synthesis of isoxazole derivatives by catalytic condensation of primary nitro compounds with dipolarophiles." Doctoral thesis, 2010. http://hdl.handle.net/2158/555297.

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9

Kuo, Ming-Luen, and 郭明倫. "Syntheses of Phenols and Calix[4]arenes with Isoxazoline or Isoxazole and Their Ring Opening Derivatives and Metal Ion Sensing Studies." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/75v352.

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碩士<br>國立交通大學<br>應用化學系碩博士班<br>107<br>We modified the lower rim of calix[4]arenes with isoxazoline or isoxazole to get the anthracene derivatives 18, 25a and 25b. by 1,3-dipolar cycloaddition. However, we could not synthesize the corresponding calix[4]arene derivatives with β-hydroxy-ketone or β-amino-α,β-unsaturated-ketone after trying the kinds of reaction conditions. Then we introduced the five member ring of isoxazole into phenol, o-benzenediol and m-benzenediol and successfully synthesized the β-amino-α,β-unsaturated-ketone derivatives 30, 34 and 38 by using Mo(CO)6 to carry out the ring-op
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10

Tsai, Shao-Ling, та 蔡韶玲. "β-Diketone, Pyrazole and Isoxazole Derivatives with Polar Groups: Liquid Crystalline and Thermodynamic Properties". Thesis, 2007. http://ndltd.ncl.edu.tw/handle/66543881468988295014.

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碩士<br>國立中央大學<br>化學研究所<br>95<br>In this serie, we report the synthesis, characterization and mesomorphic properties of two series of new mesogenic derivatives based on pyrazole and isoxazole structures. All compounds were characterized by 1H, 13C-NMR spectroscopy and elemental analysis. The phase behaviors of these mesogenic compounds were characterized and studied by differential scanning calorimeter (DSC) and polarization optical microscope. In serie one, a new type of mesogenic compounds derived from heterocyclic pyrazole and isoxazole (Iz-Cn) were prepared and studied. All compounds exhibit
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11

Xu, Ya-Zhu, and 許雅筑. "Synthesis of Isoxazole, Triazole and Naphthalidene Derivatives and Their Applications in Metal Ion Sensing." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/88245364179488604536.

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碩士<br>國立交通大學<br>應用化學系所<br>96<br>Synthesis of Isoxazole, Triazole and Naphthalidene Derivatives and Their Applications in Metal Ion Sensing (1) Application of isoxazole and triazole modified calix[4]arenes as metal ion sensing Using Click chemistry, which was promoted by professor K. B. Sharpless, we successfully synthesized p-nitrophenylazo-isoxazole- calix-[4]arene 32 and p-nitrophenylazo-anthryl-triazole-calix[4]-arene 34. Based on the results from UV-Vis spectroscopy, we found that compound 32 could recognize Ca2+ and Pb2+, however with a poor sensitivity. When compound 34 was complexed wi
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12

Guan, Qiao-Zhi, and 官巧之. "Synthesis of Chiral Isoxazole Derivatives Employing Bifunctional Thiourea Organocatalyst and 1,5-difluoro-2,4-dinitrobenzene." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/04658731297954677104.

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碩士<br>國立臺灣師範大學<br>化學系<br>99<br>This thesis deals with the synthesis of biologically active chiral bicyclic isoxazole and isoxazoline derivatives. The synthetic methodology involves two steps. In the first step, β-nitrostyrene derivatives were treated with allyl or propargyl malonates in the presence of chiral bifunctional thiourea catalyst to obtain the corresponding optically active Michael adducts. The resultant chiral Michael adducts were treated with DBU and 1,5-difluoro-2,4-dinitrobenzene (DFDNB) to generate nitrile oxides in situ. The nitrile oxide intermediates underwent intramolecular
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13

Tsai, Chia-Chen, and 蔡佳蓁. "Syntheses of Anthryl-Isoxazole Substituted Biscalix[4]arene Derivatives as Fluorogenic Sensors in Molecular Recognition." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/65130123932278822169.

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碩士<br>國立交通大學<br>應用化學系所<br>97<br>In this work, we have synthesized biscalix[4]arenes 42-46 using 1,3-dipolor cycloaddittion reactions. Our synthetic strategy for linking two calix[4]arenes involves double and quadruple cycloaddition between aryl dinitrile oxides and propargyl groups to form isoxazole biscalix[4]arenes, 42, 44 and 46. Mo(CO)6–mediated ring opening reaction of isoxazole linked biscalix[4]arenes 42 and 44, led to biscalix[4]arenes with enaminone groups, 43 and 45. Based on 1H�n�nNMR spectroscopy, we found that compound 45 composed of two atropisomers, because there is a hinder
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14

Wan-yu, Lin, and 林宛諭. "Synthesis Chiral Isoxazole Derivatives via 1,3-dipolar Cycloaddition from Michael Adducts by Using Difucntional Thiourea an Organocatalyst." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/90147113050256226100.

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碩士<br>國立臺灣師範大學<br>化學系<br>100<br>Isoxazole and isoxazoline derivatives are common and can be found in the nature compounds. The isoxazole derivatives structure are stable and facilitate for variety synthesis as intermediates. In medical system, enantiomeric isoxazole and isoxazoline are used in therapeutic process. Therefore, it becomes major tasks for synthesis enantiomeric isoxazole and isoxazoline. We have recently prepared nitrostyrene and dimethyl allyl malonate (and dimethyl propargyl malonate) with additive chiral bifunctional thiourea for 1,4-Michael addition. With H-bonding, the thiour
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15

Chen, Ching Lin, and 陳敬霖. "Metal-Free Radical Addition to Diketone via Propenone with Alkene and Cycloaddition of Dienylbenzene and Nitrosobenzene to Isoxazole Derivatives." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/8qd63x.

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碩士<br>國立清華大學<br>化學系<br>105<br>PART 1 Here, we described the synthesis of 2-substituted-3-oxo-N-phenylbutanamide through an efficient radical addition reaction. Optimizing the condition for the radical addition of alkenes with (E)-4-(phenylamino)-4-((2,2,6,6-tetramethylpiperidin-1-yl)oxy) prop-3-en-1-substituted-2-one, and we have it best performed at 120 oC in toluene that described with moderate to good yields. The structures of products consist of diketone and N-phenylamide, which could be used for further applications such as providing starting materials for Mannich reaction to synthesize n
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16

Tsai, Chia-Chen, and 蔡佳蓁. "Syntheses, Properties, and Applications of bis- Isoxazolyl-aryl Substituted Biscalixarene Derivatives." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/74514483221789511593.

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博士<br>國立交通大學<br>應用化學系碩博士班<br>101<br>In recent years, biscalix[4]arenes have been extensively studied because their structures usually contain interesting properties including the allosteric effect, intramolecular oscillation, and conformational interconversions. We have been using a strategy to construct a variety of functionalized isoxazoline and isoxazole unit(s) onto the calix[4]arene skeletons through double and/or quadruple 1,3-dipolar cycloaddition reactions of alkynes with aryl nitrile oxides. To our delight, these new series of biscalixarene derivatives contain various interesting prop
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17

Liu, Yi-Chieh, and 劉宜杰. "Syntheses, Self-assembly, and Kinetics of Bis-isoxazoyl-aryl Calix[4]arene Derivatives and Photo-responsive 1,4-Bistriazoyl-bridged Mono-calix[4]arene and Alkylaryl Derivatives." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/47k85v.

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碩士<br>國立交通大學<br>應用化學系碩博士班<br>107<br>In this thesis, we designed and synthesized 9,10-bisisoxazolylanthryl and azobenzene bridged biscalix[4]arene 46a-b and 51, and azobenzene bridged monocalix[4]arene 56a-e with long arylalkyl chain to enhance the gelation property. According to the results, compounds 56a-c and 56e could form gel in certain polar and nonpolar solvents with critical gelation concentration at 0.5-2.5 w/v %, but compounds 46a-b and 51 with long alkyl chain on the upper-rim of calix[4]arene colud not form gel at all. The gelation properties and self-assembly morphologies of 56a-c
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18

Chen, Tyng-Rong, and 陳庭蓉. "(I)Hydrogen, Halogen Bonding and Metal Ion-Induced Two Component Gel Formation of Triazolyl-pyridyl Substituted Calix[4]arene Derivatives (II)Syntheses of bis-Isoxazolyl-aryl Substituted Biscalix[4]arene Derivatives." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/jvy7sf.

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碩士<br>國立交通大學<br>應用化學系碩博士班<br>102<br>In recent years, calix[4]arene derivatives have been extensively studied in supramolecular gel formation. Although they can be used in ions recognition and oil spill recovery, they usually form one component gels. Two component gel formation of calix[4]arene was not known until Prof. Zheng’s work published in 2007. It worth noting that there have been few reports on using halogen bonding as intermolecular forces for gel formation. In this thesis, we used click chemistry reaction to synthesize triazolyl-pyridyl substituted calix[4]arene derivatives 33 , whic
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19

Chen, Wei-Hao, and 陳韋豪. "Syntheses, Selfassembly, and Photoreaction of Bisisoxazoylaryl Substituted Biscalixarene Derivatives and Polymerization of 1,3-Alternate Calixarene via Thiol-ene Photo Click Reactions." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/34985f.

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碩士<br>國立交通大學<br>應用化學系分子科學碩博士班<br>104<br>Abstract Gelator molecules usually contain long alkyl chains to increase the van der Waals interaction among them. Our previous reseach results by Ms. Tsai have reported a series of isoxazole bridged biscalix[4]arenes without any long alkyl chains. Biscalix[4]arene 61 was found to form gels in certain conditions. To increase the ability of forming gel by compound 61, we started from replacing the tbutyl group on the upperrim of compound 61 with longer alkyl chains, hoping the long chains would provide stronger van der Waals interaction during the aggr
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