Relevant bibliographies by topics / Isoxazoles

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Isoxazoles'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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Journal articles on the topic "Isoxazoles"

1

Fuse, Shinichiro, Taiki Morita, and Hiroyuki Nakamura. "Step-by-Step Multifunctionalization of Isoxazoles Based On SEAr Reactions and C–H Direct Arylations." Synthesis 49, no. 11 (2017): 2351–60. http://dx.doi.org/10.1055/s-0036-1588784.

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Functionalized isoxazoles are important as pharmaceuticals and agrochemicals. Generally, electrophilic aromatic substitution or generation of carbanions/electrophilic trapping approach is used to introduce functional groups into unsubstituted heteroaromatics. However, these approaches have not been simple to apply to unsubstituted isoxazoles due to their poor nucleophilicity and instability under basic conditions. Recently several approaches have been reported to overcome these problems. This review summarizes the functionalization of isoxazoles, including SEAr reactions and C–H direct arylati
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Wang, Xiyue, Qingyun Hu, Hui Tang, and Xinhui Pan. "Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review." Pharmaceuticals 16, no. 2 (2023): 228. http://dx.doi.org/10.3390/ph16020228.

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Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for developing novel drug candidates. Over 80 molecules with a broad range of bioactivities, including antitumor, antibacterial, anti-inflammatory, antidiabetic, cardiovascular, and other activities, were reviewed. A review of recent studies on the use of isoxazoles and isoxazolines moiety derivative activities for natural products is presented here, focusing on the parameters that affect the bioactivity of these compounds.
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Yoshimura, Akira, Akio Saito, Viktor V. Zhdankin, and Mekhman S. Yusubov. "Synthesis of Oxazoline and Oxazole Derivatives by Hypervalent-Iodine-Mediated Oxidative Cycloaddition Reactions." Synthesis 52, no. 16 (2020): 2299–310. http://dx.doi.org/10.1055/s-0040-1707122.

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Organohypervalent iodine reagents are widely used for the preparation of various oxazolines, oxazoles, isoxazolines, and isoxazoles. In the formation of these heterocyclic compounds, hypervalent iodine species can serve as the activating reagents for various substrates, as well as the heteroatom donor reagents. In recent research, both chemical and electrochemical approaches toward generation of hypervalent iodine species have been utilized. The in situ generated active species can react with appropriate substrates to give the corresponding heterocyclic products. In this short review, we summa
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Fershtat, Leonid L., Daniil A. Chaplygin, Ivan V. Ananyev, and Nina N. Makhova. "Divergent Synthesis of Five-Membered Nitrogen Heterocycles via Cascade Reactions of 4-Arylfuroxans." Synthesis 52, no. 18 (2020): 2667–78. http://dx.doi.org/10.1055/s-0040-1707393.

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A novel method for the synthesis of a diverse series of functionally substituted five-membered heterocyclic compounds via atom-economic, regio-, and diastereoselective one-pot reaction cascade was developed. This approach involves a ring opening in 4-arylfuroxans to α-oximinoarylacetonitrile oxides followed by [3+2] cycloaddition to various dipolarophiles to afford multisubstituted isoxazoles and isoxazolines. Subsequent azole–azole rearrangement of (oximino)isoxazolines/-isoxazoles, which can be conducted in a one-pot manner, results into functionally substituted furazans formation. The devel
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Chikkula, Krishna Veni, and Raja S. "ISOXAZOLE – A POTENT PHARMACOPHORE." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 7 (2017): 13. http://dx.doi.org/10.22159/ijpps.2017.v9i7.19097.

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Isoxazole is an azole with an oxygen atom next to the nitrogen. Isoxazole rings are found in some natural products, such as ibotenic acid and also found in a number of drugs, including COX-2 inhibitor valdecoxib. Furoxan, a nitric oxide donor is containing isoxazolyl group & found in many β-lactamase resistant antibiotics, such as cloxacillin, dicloxacillin and flucloxacillin. The synthetic androgenic steroid danazol also has an isoxazole ring. The substituted isoxazoles are well developed in literature to posses significant biological activities. The disubstituted and trisubstituted isoxa
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Zawadzińska-Wrochniak, Karolina, Isabelle Zavecz, and Serhii Hirka. "The recent progress in the field of the applications of isoxazoles and their hydrogenated analogs: mini review." Scientiae Radices 3, no. 4 (2024): 228–47. https://doi.org/10.58332/scirad2024v3i4a01.

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Recent review of the general application of isoxazoles and isoxazolines has been done based on current state of the art in this area. Isoxazole and its analogues have majority of possible applications in many fields of plural branches of industry. They possess good biological activity, so most of them are being used successfully in medicine and veterinary. These heterocyclic compounds could be also very important precursors of many organic transformation. Due to their easy modification, general interest of their development still increases.
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Cao, Jian-Kang, Tian-Zheng Cao, Qian-Wen Yue, et al. "tert-Butyl Nitrite-Induced Radical Nitrile Oxidation Cycloaddition: Synthesis of Isoxazole/Isoxazoline-Fused Benzo 6/7/8-membered Oxacyclic Ketones." Molecules 29, no. 6 (2024): 1202. http://dx.doi.org/10.3390/molecules29061202.

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A practical metal-free and additive-free approach for the synthesis of 6/7/8-membered oxacyclic ketone-fused isoxazoles/isoxazolines tetracyclic or tricyclic structures is reported through Csp3–H bond radical nitrile oxidation and the intramolecular cycloaddition of alkenyl/alkynyl-substituted aryl methyl ketones. This convenient approach enables the simultaneous formation of isoxazole/isoxazoline and 6/7/8-membered oxacyclic ketones to form polycyclic architectures by using tert-butyl nitrite (TBN) as a non-metallic radical initiator and N–O fragment donor.
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Griesbeck, Axel G., Marco Franke, Jörg Neudörfl, and Hidehiro Kotaka. "Photocycloaddition of aromatic and aliphatic aldehydes to isoxazoles: Cycloaddition reactivity and stability studies." Beilstein Journal of Organic Chemistry 7 (January 26, 2011): 127–34. http://dx.doi.org/10.3762/bjoc.7.18.

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The first photocycloadditions of aromatic and aliphatic aldehydes to methylated isoxazoles are reported. The reactions lead solely to the exo-adducts with high regio- and diastereoselectivities. Ring methylation of the isoxazole substrates is crucial for high conversions and product stability. The 6-arylated bicyclic oxetanes 9a–9c were characterized by X-ray structure analyses and showed the highest thermal stabilities. All oxetanes formed from isoxazoles were highly acid-sensitive and also thermally unstable. Cleavage to the original substrates is dominant and the isoxazole derived oxetanes
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M. Ahmed, Sarbast, Hewa Omer Ahmed, Faiq H. S. Hussain, Hayman Sardar Abdulrahman, and Hemn A. Qader. "Synthesis and Antimicrobial Activity of some Ester Functionalized Isoxazoles incorporating Anthracene Moieties via Nucleophilic Substitution Reaction." Zanco Journal of Medical Sciences 27, no. 2 (2023): 213–26. http://dx.doi.org/10.15218/zjms.2023.024.

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Background and objective: Five-membered heterocycle compounds having single oxygen and nitrogen atom at adjacent positions are known as isoxazoles. Isoxazole compounds have a broad range of biological activities and therapeutic value. In view of a strategic design of antimicrobial compounds, several new ester-functionalized isoxazoles were synthesized and characterized. Methods: A regioselective isoxazole incorporating an anthracene moiety was adducted via an effective 1,3-dipolar cycloaddition between anthracene nitrile oxide and propargyl bromide as a dipolarophile. Results: Synthesized isox
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Thirunarayanan, G., and V. Sathiyendiran. "Synthesis, Pharmacological and Insect Antifeedant Activities of some 3-(2-Naphthyl)-5-(Substituted Phenyl)-4,5-Dihydroisoxazoles." International Letters of Chemistry, Physics and Astronomy 49 (April 2015): 1–14. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.49.1.

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Totally thirty one 3,5-substituted aryl 4,5-dihydro isoxazole derivatives including 3-(2-naphthyl)-5-(substituted phenyl)-4,5-dihydroisoxazole have been synthesized by fly-ash:H2SO4 catalyzed cyclization of hydroxylamine hydrochloride and aryl chalcones under solvent-free conditions. The yields of the isoxazoles are more than 94%. The synthesized isoxazole were characterized by their physical constants and spectral data. The antimicrobial, antioxidant and insect antifeedant activities of the synthesized isoxazoles have been evaluated using a variety of bacterial and fungal species, DPPH radica
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Dissertations / Theses on the topic "Isoxazoles"

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Knight, Julian Gary. "Diphenylphosphinoylalkyk isoxazoles and isoxazolines." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306451.

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Tout, Jaki. "The synthesis and reactions of alkenyl isoxazoles and isoxazolines." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/14563.

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Four vinyl-isoxazoles and -2-isoxazolines have been synthesised as potential monomers for polymerisation studies. 5-Phenyl-3-vinylisoxazole was prepared in 38% overall yield by a sequence involving cycloaddition of ethoxycarbonyl-formonitrile oxide to phenylacetylene and then reduction of the resulting 3-carbethoxyisoxazole to the aldehyde using di-isobutylaluminium hydride. In the final stage Wittig olefination of the formyl-isoxazole afforded the target compound. 5-Phenyl-3-vinylisoxazole (17%) and 5-phenyl-3-vinyl-2-isoxazoline (26%) were synthesised similarily from ethyl propiolate & benzo
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Duffy, Kevin James. "Studies on the synthesis and reactivity of fused 3,4-isoxazoles." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/13734.

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This thesis is concerned with the synthesis of various fused, 3,4-isoxazoles by the thermal cyclisation of 2-nitroaryl and 2-nitroheteroaryl acetic acid derivatives and the exploitation of the uses of these compounds in heterocyclic synthesis by their reduction to afford 2-aminoaryl and heteroaryl ketones followed by the annulation of these latter derivatives. Heating solutions of 2-(3-nitropyrid-2-yl)propanedioate esters under reflux in inert solvents afforded isoxazolo[4,3-b]pyridine-3-carboxylate derivatives. The successful application of this novel synthesis on a large scale was crucially
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Lanson, Marc. "Isoxazoles polyalkyles : synthese, etude structurale et comportement en milieu biologique." Paris 6, 1987. http://www.theses.fr/1987PA066468.

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Lanson, Marc. "Isoxazoles polyalkyles synthèse, étude structurale et comportement en milieu biologique /." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb376069814.

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Duller, Kathryn April Marion. "A cycloaddition route to heterocyclic tricarbonyl natural products." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307821.

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Khatimi, Nadia. "Synthèse d'hétérocycles substitués par un groupe trifluorométhyle (isoxazoles, aziridines, thiophènes, pyrroles)." Lyon 1, 1996. http://www.theses.fr/1996LYO10177.

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Le memoire presente en vue de l'obtention du diplome de doctorat est consacre a la synthese d'heterocycles possedant un groupe trifluoromethyle. La premiere partie presente une synthese originale de plusieurs trifluoromethylisoxazoles. Ces composes ont ete utilises pour preparer des aziridines substituees par une chaine trifluoroethyle. La synthese proposee est stereoselective. Dans le deuxieme chapitre, une synthese totalement stereoselective d'aziridines substituees par un groupe trifluoromethyle est proposee: les aziridines sont obtenues par addition du trifluoromethylsilane sur des azirine
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Gayon, Eric. "Stratégies pour l'accès rapide à des hétérocycles azotés à partir d'alcools propargyliques." Thesis, Montpellier, Ecole nationale supérieure de chimie, 2012. http://www.theses.fr/2012ENCM0017/document.

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La partie principale de ce manuscrit traite du développement de nouvelles méthodologies utilisant la substitution propargylique catalysée par des sels de fer(III), pour la formation de divers hétérocycles azotés (∆4-isoxazolines, isoxazoles, cis-acylaziridines et pyrimidines). En premier lieu, de nouvelles synthèses monotopes de ∆4-isoxazolines et d'isoxazoles diversement substitués impliquant des réactions de cyclisation catalysées par diverses espèces carbophiles ([Au], [Pd], [I+]) ont été développées. La fragilité de la liaison N-O des ∆4-isoxazolines a pu être ensuite exploitée pour condui
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Blackburn, Jack. "The synthesis, attempted synthesis and applications of 1,2,4-oxadiazoles and isothiazolo-isoxazoles." Thesis, University of Huddersfield, 2014. http://eprints.hud.ac.uk/id/eprint/26888/.

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FALCOU, SERGE, and André Pierre Joseph Rassat. "Utilisation des isoxazoles en synthese : approche de la synthese de la phyllanthocine." Paris 6, 1995. http://www.theses.fr/1995PA066314.

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La synthese de la phyllanthocine et en particulier du systeme spirocetal bicyclique 6,5 fait intervenir la condensation aldolique de l'enolate du 3-acetylisoxazole sur un hydroxyaldehyde methyle. Apres la mise au point de la synthese de cet isoxazole inconnu, et suite a la mauvaise reactivite de l'enolate de cet isoxazole, une modification de la strategie de synthese nous a conduit a realiser un umpolung en condensant un alcynure sur le 3-carbomethoxyisoxazole. Cette strategie permet d'acceder au produit d'aldolisation precedemment souhaite par addition conjuguee diastereoselective d'un hemiac
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Books on the topic "Isoxazoles"

1

Grünanger, Paolo. Isoxazoles. Wiley, 1991.

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1947-, Bartlett R. R., ed. Leflunomide: Proceedings of the Vienna symposium, 12 October 1993. Birkhäuser Verlag, 1995.

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Palm, Ludger. Untersuchungen über Furo[3,4-d]isoxazole [Furo-d-isoxazole]. [s.n.], 1989.

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Toong, Samuel Y. Modulation of [alpha]-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors by a novel organic nitrate ester. National Library of Canada, 1999.

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Vita-Finzi, Paola, and Paola Grünanger. Isoxazoles, Part 1. Wiley & Sons, Incorporated, John, 2009.

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Grünanger, Paola, and Paola Vita-Finzi. Isoxazoles, Part 1. Wiley & Sons, Incorporated, John, 2007.

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Vita-Finzi, Paola, Paola Grünanger, and James E. Dowling. Isoxazoles, Part 2. Wiley & Sons, Incorporated, John, 2009.

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Grünanger, Paola, and Paola Vita-Finzi. Volume 49, Part 1, Isoxazoles. Wiley-Interscience, 1991.

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Grünanger, Paola, Paola Vita-Finzi, and James E. Dowling. Isoxazoles, Volume 49, Part 2. Wiley & Sons, Incorporated, John, 2007.

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Bartlett, Robert R. Leflunomide: Proceedings of the Vienna Symposium, 12 October 1993. Birkhauser, 1996.

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Book chapters on the topic "Isoxazoles"

1

Quilico, Adolfo. "Isoxazoles." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186787.ch1.

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Quilico, Adolfo. "Isoxazoles and Related Compounds." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186787.part1.

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Gandolfig, Remo, and Paolo Grünanger. "Partially Saturated Polynuclear Isoxazoles." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470187364.ch4.

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Badenock, Jeanese C. "Metalation Reactions of Isoxazoles and Benzisoxazoles." In Topics in Heterocyclic Chemistry. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/7081_2012_80.

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Joule, J. A., K. Mills, and G. F. Smith. "1,2-Azoles: pyrazoles, isothiazoles and isoxazoles: reactions and synthesis." In Heterocyclic Chemistry. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4899-3222-8_22.

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Silva, Artur M. S., Augusto C. Tomé, Teresa M. V. D. Pinho e Melo, and José Elguero. "Five-Membered Heterocycles: 1,2-Azoles. Part 2. Isoxazoles and Isothiazoles." In Modern Heterocyclic Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527637737.ch9.

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Gujjarappa, Raghuram, Sattu Sravani, Arup K. Kabi, et al. "An Overview on Biological Activities of Oxazole, Isoxazoles and 1,2,4-Oxadiazoles Derivatives." In Materials Horizons: From Nature to Nanomaterials. Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-8399-2_10.

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Ballistreri, Francesco Paolo, Ugo Chiacchio, Antonio Rescifina, Gaetano Andrea Tomaselli, and Rosa Maria Toscano. "Formation of Isoxazolines and Isoxazoles Via Dipolar Cycloaddition by Catalytic Oxidation of Aldoximes with Hydrogen Peroxide and W(Vi) Peroxo Complexes." In The Activation of Dioxygen and Homogeneous Catalytic Oxidation. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-3000-8_37.

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Quilico, Adolfo. "Isoxazolines." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186787.ch2.

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Li, Jie Jack. "Claisen isoxazole synthesis." In Name Reactions. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-03979-4_62.

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Conference papers on the topic "Isoxazoles"

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Ramkumar, Sowmya, and D. Nalini. "Corrosion Abatement in Acid Pickling Industries by Effective N-Heterocyclic Compounds: Dry and Wet Lab Studies." In CORROSION 2016. NACE International, 2016. https://doi.org/10.5006/c2016-07431.

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Abstract During the chemical cleaning process using acids, in many electroplating and other descaling industries, there exists the problem of heavy metal loss. Hence there is always a need for abatement of this metal loss. A critical (steady state) value of the resistivity to corrosion of two organic compounds, 5-[2-(4-methoxyphenyl)-vinyl]-3-phenyl isoxazole (MVI) and 5-[2-(4-methoxyphenyl)-vinyl]-1,3,8-triaza-cyclopenta[a]indene (MCI) were determined by a combination of non-electrochemical and electrochemical monitoring techniques. The behavior of organic compound, on a metallic alloy, i.e.,
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Mallik, Niveditha N., Chandramouli Manasa, Vrushabendra Basavanna, Dileep C. Shanthakumar, Srikantamurthy Ningaiah, and Nagarakere S. Lingegowda. "Synthesis of Fused Isoxazoles: A Comprehensive Review." In RAiSE-2023. MDPI, 2024. http://dx.doi.org/10.3390/engproc2023059222.

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Jyothi, S., M. Madhusekhar, G. Sravya, Grigory V. Zyryanov, and A. Padmaja. "Synthesis and antifungal activity of diamidomethane linked oxazolyl/thiazolyl/imidazolyl isoxazoles." In ACTUAL PROBLEMS OF ORGANIC CHEMISTRY AND BIOTECHNOLOGY (OCBT2020): Proceedings of the International Scientific Conference. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0069020.

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Amaral, Simone Schneider, and Paulo Henrique Schneider. "Regioselective Synthesis of 3-Haloalkyl-isoxazoles from the Electrophilic Cyclization of Halogenated Oximes." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0053-1.

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Marjanović, Đorđe, Dragana Medić, Tihomir Marić, and Saša Trailović. "Exploring potential antinematodal effects of some insecticides from isoxazoline group." In 36. Savetovanje dezinfekcija, dezinsekcija i deratizacija jedan svet - jedno zdravlje, Vrnjačka Banja, hotel "Vrnjačke Terme", 28-31.maj 2025.godine. Srpsko veterinarsko društvo, 2024. https://doi.org/10.5937/ddd25095m.

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Isoxazoline insecticides, such as fluralaner, afoxolaner, and sarolaner, are widely used for pest control in agriculture and veterinary medicine due to their effectiveness against arthropods like fleas, ticks, and mites. These compounds work by targeting GABA receptors and chloride ion channels in insects and arachnids. Recent studies, however, suggest that isoxazolines may also have potential in combating nematodes, which pose significant challenges in agriculture and human health. Nematodes, including parasitic and free-living species, can cause severe damage to crops and livestock. Isoxazol
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Kobayashi, Kaori, and Shozo Tsunekawa. "MICROWAVE SPECTROSCOPY OF OXAZOLE AND ISOXAZOLE." In 74th International Symposium on Molecular Spectroscopy. University of Illinois at Urbana-Champaign, 2019. http://dx.doi.org/10.15278/isms.2019.ti07.

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Silva-Alves, Diana C. B. da, Janaína V. dos Anjos, Nery N. M. Cavalcante, Daniela M. do A. F. Navarro, Geanne K. N. Santos, and Rajendra M. Srivastava. "Synthesis of new isoxazole derivatives with larvicidal activity." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0284-1.

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Vilela, G. D., R. R. da Rosa, and A. A. Merlo. "Isoxazole Derivatives With Potential Applications in Polymers and Semiconductors." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0032-1.

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Nurjanah, N., and E. Saepudin. "Curcumin isolation, synthesis and characterization of curcumin isoxazole derivative compound." In PROCEEDINGS OF THE 4TH INTERNATIONAL SYMPOSIUM ON CURRENT PROGRESS IN MATHEMATICS AND SCIENCES (ISCPMS2018). AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5132492.

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Liu, Hongliang, Gang Liu, and Weijun Liu. "Photochromism and optical recording of a novel diarylethene bearing isoxazole unit." In 2011 4th International Congress on Image and Signal Processing (CISP 2011). IEEE, 2011. http://dx.doi.org/10.1109/cisp.2011.6100550.

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