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Dissertations / Theses on the topic 'Isoxazoles'

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Published: 4 June 2021
Last updated: 25 July 2025

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1

Knight, Julian Gary. "Diphenylphosphinoylalkyk isoxazoles and isoxazolines." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306451.

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2

Tout, Jaki. "The synthesis and reactions of alkenyl isoxazoles and isoxazolines." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/14563.

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Four vinyl-isoxazoles and -2-isoxazolines have been synthesised as potential monomers for polymerisation studies. 5-Phenyl-3-vinylisoxazole was prepared in 38% overall yield by a sequence involving cycloaddition of ethoxycarbonyl-formonitrile oxide to phenylacetylene and then reduction of the resulting 3-carbethoxyisoxazole to the aldehyde using di-isobutylaluminium hydride. In the final stage Wittig olefination of the formyl-isoxazole afforded the target compound. 5-Phenyl-3-vinylisoxazole (17%) and 5-phenyl-3-vinyl-2-isoxazoline (26%) were synthesised similarily from ethyl propiolate & benzo
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3

Duffy, Kevin James. "Studies on the synthesis and reactivity of fused 3,4-isoxazoles." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/13734.

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This thesis is concerned with the synthesis of various fused, 3,4-isoxazoles by the thermal cyclisation of 2-nitroaryl and 2-nitroheteroaryl acetic acid derivatives and the exploitation of the uses of these compounds in heterocyclic synthesis by their reduction to afford 2-aminoaryl and heteroaryl ketones followed by the annulation of these latter derivatives. Heating solutions of 2-(3-nitropyrid-2-yl)propanedioate esters under reflux in inert solvents afforded isoxazolo[4,3-b]pyridine-3-carboxylate derivatives. The successful application of this novel synthesis on a large scale was crucially
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4

Lanson, Marc. "Isoxazoles polyalkyles : synthese, etude structurale et comportement en milieu biologique." Paris 6, 1987. http://www.theses.fr/1987PA066468.

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5

Lanson, Marc. "Isoxazoles polyalkyles synthèse, étude structurale et comportement en milieu biologique /." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb376069814.

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6

Duller, Kathryn April Marion. "A cycloaddition route to heterocyclic tricarbonyl natural products." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307821.

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7

Khatimi, Nadia. "Synthèse d'hétérocycles substitués par un groupe trifluorométhyle (isoxazoles, aziridines, thiophènes, pyrroles)." Lyon 1, 1996. http://www.theses.fr/1996LYO10177.

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Le memoire presente en vue de l'obtention du diplome de doctorat est consacre a la synthese d'heterocycles possedant un groupe trifluoromethyle. La premiere partie presente une synthese originale de plusieurs trifluoromethylisoxazoles. Ces composes ont ete utilises pour preparer des aziridines substituees par une chaine trifluoroethyle. La synthese proposee est stereoselective. Dans le deuxieme chapitre, une synthese totalement stereoselective d'aziridines substituees par un groupe trifluoromethyle est proposee: les aziridines sont obtenues par addition du trifluoromethylsilane sur des azirine
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8

Gayon, Eric. "Stratégies pour l'accès rapide à des hétérocycles azotés à partir d'alcools propargyliques." Thesis, Montpellier, Ecole nationale supérieure de chimie, 2012. http://www.theses.fr/2012ENCM0017/document.

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La partie principale de ce manuscrit traite du développement de nouvelles méthodologies utilisant la substitution propargylique catalysée par des sels de fer(III), pour la formation de divers hétérocycles azotés (∆4-isoxazolines, isoxazoles, cis-acylaziridines et pyrimidines). En premier lieu, de nouvelles synthèses monotopes de ∆4-isoxazolines et d'isoxazoles diversement substitués impliquant des réactions de cyclisation catalysées par diverses espèces carbophiles ([Au], [Pd], [I+]) ont été développées. La fragilité de la liaison N-O des ∆4-isoxazolines a pu être ensuite exploitée pour condui
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9

Blackburn, Jack. "The synthesis, attempted synthesis and applications of 1,2,4-oxadiazoles and isothiazolo-isoxazoles." Thesis, University of Huddersfield, 2014. http://eprints.hud.ac.uk/id/eprint/26888/.

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10

FALCOU, SERGE, and André Pierre Joseph Rassat. "Utilisation des isoxazoles en synthese : approche de la synthese de la phyllanthocine." Paris 6, 1995. http://www.theses.fr/1995PA066314.

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La synthese de la phyllanthocine et en particulier du systeme spirocetal bicyclique 6,5 fait intervenir la condensation aldolique de l'enolate du 3-acetylisoxazole sur un hydroxyaldehyde methyle. Apres la mise au point de la synthese de cet isoxazole inconnu, et suite a la mauvaise reactivite de l'enolate de cet isoxazole, une modification de la strategie de synthese nous a conduit a realiser un umpolung en condensant un alcynure sur le 3-carbomethoxyisoxazole. Cette strategie permet d'acceder au produit d'aldolisation precedemment souhaite par addition conjuguee diastereoselective d'un hemiac
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11

Michaud, Thierry. "Synthese d'heterocycles azotes enatiomeriquement purs (aziridines, azetidines, isoxazoles) au depart de monosaccharides." Clermont-Ferrand 2, 1995. http://www.theses.fr/1995CLF21711.

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Un axe important de la chimie des glucides est leur utilisation comme source de chiralite dans la synthese de molecules a proprietes biologiques potentielles. Notre objectif a ete la synthese d'azetidines polyhydroxylees substituees en 2 et 3, enantiomeriquement pures, au depart de monosaccharides. Des ditosylates en 4,6 ont ete prepares en quatre etapes au depart des d-gluco- et d-mannopyranose par acetalisation, c-alkylation, hydrolyse et tosylation. Dans la serie du d-glucopyranose l'action d'amines primaires (methyl-, benzyl-, et tertbutylamine) sur les derives ditosyles permet d'acceder,
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12

Dawson, Claire E. "A cycloaddition route to heterocyclic triones." Thesis, University of Nottingham, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243698.

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13

Kivrak, Arif. "Development Of New Methods For The Synthesis Of Pyrazoles, 4-iodopyrazoles, Isoxazoles And 1,2,4-oxadiazoles." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12612945/index.pdf.

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Synthesis of five-membered heteroaromatic compounds such as pyrazoles, isoxazoles and 1,2,4-oxadiazoles are important for pharmaceutical industry and material science due to their applications. Although there are many methods to prepare such compounds, new variants continue to appear since they exhibit a wide range of biological and medicinal activities. In this thesis, new methods were developed for the synthesis of 4-iodopyrazoles, pyrazoles, isoxazoles, 1,2,4-oxadiazoles and/or 1,2,4-oxadiazepines. In the first part of the study, electrophilic cyclization of &alpha<br>,&beta<br>-alkynic hy
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14

Perez, Vincent. "Synthèses sélectives d’isoxazolines et isoxazoles phosphonates : compétition de C- vs. O-alkylation et cycloadditions d’ynamido-phosphonates." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS363.

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En raison de la vaste gamme d'activités biologiques qu'ils possèdent, les aminophosphonates cycliques ont attiré l’attention des chimistes et des biologistes. La synthèse d’hétérocycles substitués par un atome de phosphore a largement été rapportée dans la littérature. Dans ce contexte, le premier défi a été de proposer une nouvelle voie d'accès au motif 5-phosphono-isoxazoline. Une méthodologie a été développée, reposant sur la formation de N-oxydes d’isoxazolines par réaction de O-alkylation d’un ion nitronate sur un composé α-substitué vinylphosphonate, suivie d’une réduction pour former le
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15

Thenna, Hewa Kosala R. S. "Applications Focused Synthetic Modification on Photoremovable Protecting Groups (PRPG) & Photochemical Analysis on Organic Azides and Isoxazoles." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1511858669354976.

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16

ARICHI, JAOUAD. "Extraction liquide-liquide de terres rares par des 4-acyl-5-hydroxy-pyrazoles et -isoxazoles equilibres et cinetique de transfert. Synergies." Université Louis Pasteur (Strasbourg) (1971-2008), 1998. http://www.theses.fr/1998STR13007.

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L'extraction liquide-liquide de terres rares trivalentes (ln#3#+) a partir du milieu nitrate par des 4-acyl-5-hydroxy-pyrazoles, -ceto-enols notes ha, a ete etudiee. L'extraction croit avec le numero atomique croissant de ln et avec l'acidite croissante de ha, mais aux depens de la selectivite. La presence d'un agent de solvatation, s, associe a ha, de type o-donneur tel l'ether-couronne dibenzo-18-couronne-6 ou de type n-donneur comme la 2,4,6-tri(2-pyridyl)-1,3,5-triazine (tpytz) provoque un effet synergique important, avec l'extraction de complexes lna#3s, selon l'ordre db18c6 << tpytz. Par
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17

Piovesan, Luciana Almeida. "Avaliação da atividade antimicrobiana de derivados isoxazóis." Universidade Federal de Santa Maria, 2005. http://repositorio.ufsm.br/handle/1/10395.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Isoxazoles compounds have been showing a great variety of pharmacological activities. Such activities might be increased by the presence of halomethyl-substitute groups in isoxazoles. This work shows the synthesis of the series of 5-trichloromethyl-5-hydroxi-4,5- dihydroisoxazoles 2a-o, 5-carboxy-isoxazoles 3a-o e 3-aryl-5- trichloro(fluoro)methylisoxazoles, 4j, 4p-t, 5j, 5p-t compounds, and further evaluation of the antimicrobial activity, by using the broth dillution technique, considering a bank of catalogued strains, represen
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18

Rosa, Fernanda Andreia. "Reação de β-dimetilaminovinil cetonas com hidroxilamina: regioquímica de formação de 4,5-diidroisoxazóis e de isoxazóis". Universidade Federal de Santa Maria, 2005. http://repositorio.ufsm.br/handle/1/10412.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The regiochemistry study of the formation of a series of aryl-, heteraryl- and haloalkyl-substituted isoxazoles from the reaction of β-dimethylaminovinyl ketones and hydroxylamine is reported. The precursors β-imethylaminovinyl ketones were obtained from the condensation reaction of N,N-dimethylformamide dimethyl acetal and the substituted ketones [R-C(O)-CH3, where R = Ph, MeO-4-C6H4, Me-4-C6H4, F-4-C6H4, Cl- 4-C6H4, Br-4-C6H4, O2N-4-C6H4, Fur-2-yl, Tien-2-yl, Pyrrol-2-yl, Pyrid-2-yl, and CCl3]. The study shown that for R = trich
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19

Debleds, Olivier. "Substitutions propargyliques : méthodologie & développements synthétiques." Montpellier 2, 2009. http://www.theses.fr/2009MON20159.

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Le travail présenté dans ce manuscrit concerne le développement de nouvelles réactions utilisant la substitution propargylique par des complexes d'or (III) et de fer (III). En premier lieu, une exploration du champ d'application de cette méthodologie a été réalisée, ce qui a conduit par la suite, à la mise au point de nouvelles méthodes d'accès aux 2,3-dihydroisoxazoles, aux isoxazoles et ainsi qu'aux acylaziridines. Enfin, le développement d'une nouvelle méthodologie d'accès aux cycles à quatre chaînons par métathèse a pu être exploré<br>The work reported in this manuscript concerned the deve
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20

Friedein, Alynne Alegre Souto. "Síntese de novos azóis derivados da 1,1- difenilacetona." Universidade Federal de Santa Maria, 2014. http://repositorio.ufsm.br/handle/1/10591.

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This work describes an efficient method to obtaining new heterocycles from the reaction of acetalization of the ketonic carbonyl, followed by acylation of the enolether, generated in situ from the acetal derivative of 1,1-diphenylacetone, with trifluoroacetic anhydride, tricloroacetila of chloride, clorodiflúoracético anhydride, pentaflúorpropiônico anhydride in the absence of solvents. There were performed reactions of cyclocondensation between 1,1,1-trialo-4-alkoxy-3-alquen-2-ones and hydroxylamine hydrochloride, forming, in general, the 5-trialometil-5-hydroxy-4,5-diidroisoxazóis. To obtain
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21

Sperança, Adriane. "Síntese de Seleno-Isoxazóis e Seleno-Indóis via Reações de Ciclização Intramolecular mediadas por Cloreto Férrico." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/4241.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>This work reports the synthesis of a series of 4-organoselenyl-isoxazoles (19 examples), prepared via FeCl3/diorganyl diselenides-promoted intramolecular cyclization of alkynone O-metyloximas. In general, the selenyl-isoxazoles were obtained, in 50 to 70% yield. In addition, an alternative method was developed to promote the intramolecular cyclization reaction of o-alkynyl-N,N-dimethyl-anilines, where FeCl3 and substituted diorganyl diselenides were employed as promoter agents to this process. Through this cyclization protocol a
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22

Roy, Amélie. "Synthetic studies of the formation of oxazoles and isoxazoles from N-acetoacetyl derivatives, scope and limitations ; and Aqueous rhodium-catalyzed Heck-type coupling reactions between boronic acids and olefins." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0021/MQ53366.pdf.

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23

Meyer, Alexandre Robison. "Interações intermoleculares e topologia molecular no empacotamento cristalino de 3-amino-4-halo-5-metilisoxazóis." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/10542.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>In this work is described the intermolecular interactions and the molecular topology present in the crystal packing of 3-amine-4-halo-5-methylisoxazoles. First was described the obtention of the 3-amine-4-halo-5-methylisoxazoles by halogenations of the compound 3-amine-5-methylisoxazol with N-chlorosuccinimide, N-bromosuccinimide and N-iodoosuccinimide. The crystal packing of the 3-amine-4- halo-5-methylisoxazoles show a great variety of intermolecular interactions such as: hydrogen bonding, halogen bonding, π π interactions and
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24

Longhi, Kelvis. "Nh-pirazóis e isoxazóis: síntese mecanicamente ativada por grinding." Universidade Federal de Santa Maria, 2010. http://repositorio.ufsm.br/handle/1/10474.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>The synthesis of twelve NH-pyrazoles from the cyclocondensation reaction of β-dimethylaminovinylketones ([R1C(O)C(R2)=CHN(Me)2], where R1 = Me, C6H5, 3- MeO-C6H4, 4-Me-C6H4, 4-MeO-C6H4, 4-F-C6H4, 4-Cl-C6H4, 4-Br-C6H4, 4-O2N-C6H4, fur-2-il, tien-2-il; R2 = H, 2-MeO-C6H4 and R1, R2 = -(CH2)3C(O)- with hydrazine sulfate is reported. In this work, it was also demonstrated the synthesis of twelve isoxazoles from the cyclocondensation reaction of β-dimethylaminovinylketones where R1 = Me, C6H5, 3-MeO-C6H4, 4-Me-C6H4, 4-MeO-C6H4, 4-F-C6
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25

Campos, Patrick Teixeira. "β-Enaminonas, 5-hidróxi-4,5-diidropirazóis e 5-Hidróxi-4,5-diidroisoxazóis halometilsubstituídos: estudo molecular por difração de raios-x". Universidade Federal de Santa Maria, 2008. http://repositorio.ufsm.br/handle/1/10435.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The molecular study by X-ray diffraction of β-aminovinyl ketones [R3C(O)CH=C(R1)N(R4R5), onde R3 = CF3, CCl3, CHCl2; R1 = H, Me; R4 = H; R5 = benzyl, Ph, 5-methylisoxazol-3-yl; R4, R5 = -(CH2)4-, -(CH2)2O(CH2)2-], methyl 5- hydroxy-5-trihalomethyl-4,5-dihydro-1H-pyrazole-1-carboxylate [3-(R1), 4-(R2), and 5- (R3) substituted, where R1 = H, Me; R2 = H, Me; R3 = CCl3, CF3], 1-cyanoacetyl-5- trifluorometyl-5-hydroxy-4,5-dihydro-1H-pyrazole [3-(R1) and 4-(R2) substituted, where R1 = H, Ph; R1, R2 = -(CH2)4-, R2 = H] and 5-triclorometyl
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26

Meunier, Andreas. "Cyclooxygenase-2 inhibitors and knee prosthesis surgery." Doctoral thesis, Linköping : Department of Clinical and Experimental Medicine, Linköping University, 2008. http://www.bibl.liu.se/liupubl/disp/disp2008/med1077s.pdf.

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27

Garcia, Fábio Dutra. "Novos Espirocromenil-Trifluoretanonas a partir de Reações de Trifluoracetilação de Adutos de Kabbe e seus Espiro[diidrocromeno-cicloalcan]pirazóis e Isoxazóis Derivados." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/10564.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>This work describes firstly an efficient and regioselective method for the synthesis of a new series of 2,2,2-trifluoro-1-[4-methoxy-spiro(2H-chromen-2,1 -cycloalkan)-3-yl]ethanones from the Kabbe adducts (spiro[chroman-2,1 -cycloalkan]-4-ones). Yields of 38 % to 61 % were obtained when trifluoroacetylation reactions of mixtures of enolethers and/or acetals derived from four spiro ketones (Kabbe adducts) were performed at a temperature of 45 oC and employing anhydrous chloroform as the solvent. Subsequently, when the respective tri
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28

Yuen, Wing Hoi. "An isoxazole approach to the coleophomones." Thesis, Loughborough University, 2007. https://dspace.lboro.ac.uk/2134/11718.

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Coleophomones, metabolites reported first in a Japanese patent in 1998 and then by Merck in 2000 from a Coleophoma fungus, have antifungal and antibacterial properties and inhibit bacterial cell-wall transglycosylase and human heart chymase. Their unique molecular architecture contains a cyclic tricarbonyl moiety embedded in an ll-membered macrocycle. In our synthetic strategy the reactive ~,~-tricarbonyl structure is masked as an isoxazole to allow elaboration elsewhere in the molecule. We have investigated two isoxazole based approaches to these targets: 1) via an isoxazole ring with ketone
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29

Silva, Givanildo Santos da. "Estudos estruturais e em química medicinal visando a identificação de novos inibidores da acetilcolinesterase Ipisox, Prisox, Ocisox, 4d, b07, 13b e c90." Universidade Federal de Alagoas, 2016. http://www.repositorio.ufal.br/handle/riufal/1865.

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This work presents a crystal chemistry study of seven compounds grouped into three classes: isoxazoles, pyrazoles and pyrazolines here called IPISOX, PRISOX, 4D, OCISOX, C90, B07 e 13B, in order to identify novel acetylcholinesterase inhibitors. The structures of the listed compounds were determined by X-ray diffraction method using monocrystalline samples of the aforementioned substances. The disagreement rates seen between the model and the model defined by the diffraction pattern were: 0.0708; 0.0399; 0.0513; 0.0562; 0.0726; 0.0519; 0.0457 to IPISOX, PRISOX, OCISOX, 4D, B07, 13B e C90, resp
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30

Moschref, Said-Nadjib. "Synthese und Umlagerung von mono-metallierten Bisallylethersystemen und die Synthese von mono-metallierten Isoxazolen." [S.l. : s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=962341290.

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31

Rosa, Rafaela Raupp da. "Isoxazolinas e isoxazóis como reais candidatos na preparação de cristais líquidos polares." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2018. http://hdl.handle.net/10183/180639.

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A presente tese descreve a síntese e caracterização de 10 novas séries de moléculas na forma de banana contendo os anéis isoxazolina e isoxazol como reais candidatos na preparação de cristais líquidos polares. Foram avaliados parâmetros estruturais tais como o tipo de função conectora do centro curvado com os braços mesogênicos, a natureza do heterociclo e a sua posição relativa ao núcleo. A síntese dos compostos contou com a metodologia de preparação do anel isoxazolina, a cicloadição [3+2] 1,3-dipolar entre alcenos e óxidos de nitrila, os quais foram gerados pelas oximas preparadas a partir
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32

Gsour, Amna. "Differentiation of human cell line towards a pancreatic endocrine lineage." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/differentiation-of-human-cell-line-towards-a-pancreatic-endocrine-lineage(0c2c21fe-724d-449f-804c-02741c89828c).html.

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Islet transplantations have been successful in restoring glucose homeostasis in patients with diabetes; however, the limited number of donor organs limits the success of this treatment. The lineage reprograming of different cell sources to beta cells potentially provides an unlimited supply of insulin-producing cells for regenerative therapy for patients with diabetes. The aim of this study was to investigate the ability to transdifferentiate two cell lines into an endocrine lineage. Insulin production in pancreatic beta cells can be increased using a small molecule, 3,5-disubstituted isoxazol
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33

Hollis, Stephen James. "Heterocycles in peptide chemistry." Thesis, Open University, 2000. http://oro.open.ac.uk/54180/.

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The synthesis of 5-membered heterocyclic rings that bear both amine and carboxylic acid functional groups has been investigated using a 1,3-dipolar cycloaddition reaction strategy. These molecules, on incorporation into a chain of amino acids, have the potential to restrict the conformational freedom of the peptide. Cycloaddition of a nitrile oxide, derived from a Boc-protected naturally-occurring a-amino acid, with a pyrrolidine en amine led to a Boc-protected 3-aminoalkylisoxazole amino acid ester. The nitrogen and carbon termini of this isoxazole were coupled to other a-amino acids. Analysi
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34

Stiirmer, Júlio César. "Síntese de bismesógenos derivados do isoxazol." Florianópolis, SC, 2000. http://repositorio.ufsc.br/xmlui/handle/123456789/79050.

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Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas. Curso de Pós-Graduação em Química<br>Made available in DSpace on 2012-10-17T22:37:56Z (GMT). No. of bitstreams: 0Bitstream added on 2014-09-25T16:14:53Z : No. of bitstreams: 1 182716.pdf: 3357298 bytes, checksum: 7e79e068bbc9aea9bb290a481be0b28d (MD5)<br>Síntese de Cristais Liquidos Calamíticos constituídos de sistemas chamados de bismesógenos é apresentada. Estes sistemas possuem dois centros rígidos conectados por uma cadeia flexível. O centro rígido é constituído pelo anel isoxazol 3,5
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35

Correia, de Almeida Gleybson. "Síntese e avaliação preliminar da atividade antimicrobiana e antichagásica de novas isoxazolil-aril-semicarbazonas, e tiossemicarbazonas e isoxazolil-nitrofurfuril-hidrazonas." Universidade Federal de Pernambuco, 2010. https://repositorio.ufpe.br/handle/123456789/2969.

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Made available in DSpace on 2014-06-12T16:25:37Z (GMT). No. of bitstreams: 2 arquivo1125_1.pdf: 3490678 bytes, checksum: 347a62790e8d9bfb7abcdf2e63109656 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2010<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Na literatura, há um grande número de trabalhos que buscam obter derivados de semicarbazonas e tiossemicarbazonas, contendo heterociclos, com aplicações farmacológicas, como antimicrobiana, antichagásica, antifúngica, antineoplásica e anticonvulsivante. Pesquisas vêm obte
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Gamage, Disnani W. "Comparison of Isoxazole and Azirine as precursor to triplet vinyl nitrene." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1337351136.

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Fritz, Martina Désirée. "p38 MAP Kinase Inhibitoren : Synthese, Analytik und biologische Testung substituierter Isoxazole /." [S.l. : s.n.], 2004. http://www.gbv.de/dms/bs/toc/39191703X.pdf.

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Wierschem, Frank Georg. "Darstellung und Modifizierung von 2-Oxo-piperazin-basierenden Isoxazolinen und Isoxazolidinen in Lösung und an fester Phase." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971626812.

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Lopes, Luana Dezingrini. "Síntese de moléculas fluoradas contendo o núcleo isoxazol." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/107021.

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No mundo dos heterociclos de 5 membros, o isoxazol recebe atenção devido à sua ampla empregabilidade em produtos biológicos, farmacêuticos e tecnológicos. Além das suas propriedades medicinais bastante conhecidas, isoxazóis são intermediários interessantes em síntese orgânica, e desempenham um papel importante na síntese de novos materiais líquido-cristalinos. A combinação de diferentes características interessantes estimulou o estudo da influência do flúor nas propriedades dos compostos orgânicos. Os atributos importantes desse substituinte asseguram que modificações significativas são freque
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Huppé, Sylvain. "La chimie des 5-isoxazolones : des β-cétoesters aux acétyléniques". Paris 11, 1996. http://www.theses.fr/1996PA112295.

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Lobo, Marcio Marçal. "Síntese regiosseletiva de Dideoxinucleosídeos e 3(5)-Trifluormetil-1H-pirazóis de interesse farmacológico." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/4276.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>This work reports the synthesis of a series of 29 new 1-(3-aryl-4,5-dihydroisoxazol-5-yl)methyl-4-trihalomethylpyrimidin-2(1H)-ones which have high pharmacological interest, since they are similar to natural and synthetic nucleosides. These compounds were obtained from 1,3-dippolar cycloaddition reaction between the 1-allyl-(6-aryl)-4-trihalomethylpyrimidin-2(1H)-ones and different benzonitrile oxides, obtained from the selected oximes of general formula ArCH=NOH (where Ar = Ph, 4-FC6H4, 2-MeC6H4, 4-MeC6H4, 2-MeOC6H4, 4-MeOC6H4,
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Lucas-Andrzejak, Virginie. "Conception, synthèse et évaluation pharmacologique de nouveaux inhibiteurs de la Fatty Acid Amide Hydrolase (FAAH) potentiellement utilisables dans le traitement des Maladies Inflammatoires Chroniques de l'intestin (MICI)." Phd thesis, Université du Droit et de la Santé - Lille II, 2010. http://tel.archives-ouvertes.fr/tel-00590867.

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Les MICI (maladies inflammatoires chroniques de l'intestin) invalident 200 000 personnes en France. La région Nord-Pas-de-Calais est particulièrement touchée par ces affections et les traitements disponibles pour ces pathologies demeurent coûteux et peu nombreux. Des études récentes ont suggéré que le système endocannabinoïde, exprimé au seing du tractus gastro-intestinal, est une cible thérapeutique prometteuse pour le traitement des MICI. Ce système se compose des récepteurs aux cannabinoïdes CB1 et CB2, des ligands endogènes de ces récepteurs, notamment l'anandamide et le 2-arachidonoylglyc
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Bryk, Fernando Rebouças. "Síntese regiosseletiva de cristais líquidos contendo o heterociclo isoxazol." Florianópolis, SC, 2008. http://repositorio.ufsc.br/xmlui/handle/123456789/91898.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas. Programa de Pós-Graduação em Química<br>Made available in DSpace on 2012-10-24T03:40:18Z (GMT). No. of bitstreams: 1 260043.pdf: 3765314 bytes, checksum: 24336dd964ac4d5fddd8cd096f286373 (MD5)<br>Moléculas com características líquido-cristalinas têm ultimamente atraído um grande interesse por parte de vários grupos de pesquisa e principalmente por empresas do ramo da tecnologia. Esse interesse reside em grande parte, pelas suas propriedades únicas, as quais se aplicam a muitos aspectos d
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Mancuso, Vincent. "Nouvelle voie de synthèse de bêta-aminocétones via les Delta4-isoxazolines." Doctoral thesis, Universite Libre de Bruxelles, 1990. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/213161.

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MESSAOUDI, ABDELKADER. "Extraction liquide-liquide du strontium par le 3-phenyl-4-benzoyl-5-hydroxy-isoxazole. Synergies." Université Louis Pasteur (Strasbourg) (1971-2008), 1993. http://www.theses.fr/1993STR13112.

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La methode de preparation du 3-phenyl-4-benzoyl-5-hydroxy-isoxazole (hpbi) a ete optimisee. Les mesures de constante d'acidite en systeme liquide-liquide ont montre que hpbi est un acide relativement fort compare au 1-phenyl-3-methyl-4-benzoyl-5-hydroxy-pyrazole (hpmbp) ou aux -dicetones. L'etude de l'extraction synergique de sr#2#+, ba#2#+, mg#2#+ et de cs#+ par des melanges de hpbi et d'ethers-couronnes (e), de sels d'ammonium (b#+, x#), et d'oxyde de tri-n-octylphosphine (topo) dans le chloroforme et le toluene, montrent que l'echange proton-metal est operant des ph 2. Avec les ethers-couro
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Rosa, Rafaela Raupp da. "Núcleo isoxazol na síntese e caracterização de cristais líquidos curvos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/88550.

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Este trabalho descreve a síntese e caracterização de três novas séries de compostos líquido-cristalinos derivados de isoxazóis com estruturas curvas. Foram empregadas metodologias clássicas de síntese na preparação dos compostos, sendo a reação de ciclo-adição [3+2] 1,3-dipolar a etapa chave da rota sintética. Adicionalmente foi feito o estudo teórico de análise conformacional e estado excitado dos compostos finais. A caracterização foi feita utilizando-se técnicas de ressonância magnética nuclear de hidrogênio (RMN de 1H) e carbono 13 (RMN de 13C), espectrometria de massas, microscopia ótica
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Chatterley, Alexander. "Benzisoxazoles : new routes to coleophomone analogues." Thesis, Loughborough University, 2014. https://dspace.lboro.ac.uk/2134/16261.

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This project has been part of an ongoing interest in metabolites with a cyclic tricarbonyl motif 1, usually enolised. Coleophomones A C have a unique architecture with the cyclic tricarbonyl motif embedded in an 11-membered ring: A & B exist in aldol equilibrium, B & C are geometric isomers, and D lacks the macrocycle.1,2 Antifungal & antibiotic activity, and inhibition of human heart chymase & bacterial cell-wall transglycosylase, has generated synthetic interest. In an approach distinct from reported studies,3 we propose 4-carbonyl-substituted isoxazoles, from dipolar cycloaddition of nitril
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Välimäki, M. (Mika). "Discovery of cardioprotective isoxazole-amide compounds targeting the synergy of transcription factors GATA4 and NKX2-5." Doctoral thesis, M. Välimäki, 2018. http://urn.fi/urn:isbn:9789529412525.

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Abstract Acute myocardial infarction is a life-threatening condition that occurs as a result of reduced blood flow in the cardiac muscle, eventually leading to tissue damage. In infarcted areas, cardiomyocytes have insufficient ability to proliferate and replace the injured cells, which is associated with a deficient pumping capacity. A strictly regulated combinatorial interplay of transcription factors, e.g., GATA4, NKX2-5, TBX5, and MEF2C, orchestrates cardiac type gene expression during the cardiomyocyte differentiation and maturation processes. The aim of the present study was to (i) chara
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49

Fritsch, Luma. "Síntese de novos cristais líquidos derivados de base de schiff com núcleo isoxazolina/isoxazol." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/129750.

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Esta dissertação apresenta a síntese e caracterização espectroscópica e térmica de duas novas series de bases de Schiff líquido cristalinas contendo o anel isoxazolina e isoxazol. Foram sintetizados 22 bases de Schiff da série (E)-N-[4-(alquiloxi)benzilideno]-4-[5-(X)-4,5-dihidroisoxazol-3-il]anilinas (8c-i) e 22 bases de Schiff da série (E)-N-[4-(alquiloxi)benzilideno]-4-[5-(X)-isoxazol-3-il]anilinas (8c´-i´). Em ambas as séries, o grupo X é CH3 para 8c/8c’; Cl para 8d/8d’; Br para 8e/8e’; H para 8f/8f’; n-Butila; para 8h/8h’ e 2-Etilhexila para 8i/8i’. O substituinte alquiloxila em ambas as
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Baranovic, Jelena. "Structural and functional characterization of reconstituted alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors." Thesis, University of Oxford, 2011. https://ora.ox.ac.uk/objects/uuid:008f579f-828a-4792-8a2c-d2beffda458d.

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This thesis describes a novel reconstitution of &alpha;-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) for the purposes of structural characterization by atomic force microscopy (AFM) and functional characterization by electrical recordings of lipid bilayers. AMPARs are glutamate gated ion channels, ubiquitous in the vertebrate central nervous system where they mediate fast excitatory neurotransmission. In a healthy brain, AMPARs are involved in memory formation and learning and their dysfunction has been related to numerous neurological disorders such as Alzheimer's di
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