Relevant bibliographies by topics / Isoxazoline derive

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Academic literature on the topic 'Isoxazoline derive'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Isoxazoline derive"

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Bartolotta, Roberta, Concetta La Rosa, and Donatella Nava. "New Strategy of Synthesis of Peramivir Analogues as Potential Neuraminidase Inhibitors." Synthesis 52, no. 06 (2019): 933–41. http://dx.doi.org/10.1055/s-0039-1690039.

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Highly functionalised potential neuraminidase (NA) inhibitors, analogues of peramivir, were synthesised via a new and versatile method starting from a stereoselective 1,3-dipolar cycloaddition reaction between the nitrile oxide derived from 2-ethylbutanal and the commercially available and inexpensive cyclopentadiene and 1,3-cyclohexadiene, which afforded the isoxazolino-cyclopentene or cyclohexene intermediates, respectively. The subsequent reaction of the C=C bond in different conditions allowed the functionalisation of the five (or six) membered carbon nucleus. Further functionalised deriva
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2

Ciura, Krzesimir, Joanna Fedorowicz, Hanna Kapica, Monika Pastewska, Wiesław Sawicki, and Jarosław Sączewski. "Interaction between Antifungal Isoxazolo[3,4-b]Pyridin 3(1H)-One Derivatives and Human Serum Proteins Analyzed with Biomimetic Chromatography and QSAR Approach." Processes 9, no. 3 (2021): 512. http://dx.doi.org/10.3390/pr9030512.

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The development of effective, nontoxic antifungal agents is one of the most important challenges for medicinal chemistry. A series of isoxazolo [3,4-b]pyridine-3(1H)-one derivatives previously synthesized in our laboratory demonstrated promising antifungal properties. The main goal of this study was to investigate their retention behavior in a human serum proteins-high-performance liquid chromatography (HSA-HPLC) system and explore the molecular mechanism of HSA-isoxazolone interactions using a quantitative structure–retention relationship (QSRR) approach. In order to realize this goal, multip
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3

Khlebnikov, Alexander F., Mikhail S. Novikov, Yelizaveta G. Gorbunova, et al. "Isoxazolium N-ylides and 1-oxa-5-azahexa-1,3,5-trienes on the way from isoxazoles to 2H-1,3-oxazines." Beilstein Journal of Organic Chemistry 10 (August 14, 2014): 1896–905. http://dx.doi.org/10.3762/bjoc.10.197.

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Theoretical and experimental studies of the reaction of isoxazoles with diazo compounds show that the formation of 2H-1,3-oxazines proceeds via the formation of (3Z)-1-oxa-5-azahexa-1,3,5-trienes which undergo a 6π-cyclization. The stationary points corresponding to the probable reaction intermediates, isoxazolium N-ylides, were located by DFT calculations at the B3LYP/6-31G(d) level only for derivatives without a substituent in position 3 of the isoxazole ring. These isoxazolium N-ylides are thermodynamically and kinetically very unstable. According to the calculations and experimental result
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4

Aouadi, Kaïss, Sébastien Vidal, Heithem Abda, and Moncef Mssadek. "Synthesis of Some Isoxazolidine and Isoxazoline Derivatives Using Nitrone-Derived (‒)-Menthone via 1,3-Dipolar Cycloaddition with Alkenes, Alkynes and Cycloalkenes." HETEROCYCLES 92, no. 11 (2016): 1963. http://dx.doi.org/10.3987/com-16-13532.

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5

Liu, Xiujun, Xiang Ma та Yaqing Feng. "Introduction of an isoxazoline unit to the β-position of porphyrin via regioselective 1,3-dipolar cycloaddition reaction". Beilstein Journal of Organic Chemistry 15 (28 червня 2019): 1434–40. http://dx.doi.org/10.3762/bjoc.15.143.

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Isoxazoline-linked porphyrins have been synthesized by a regioselective 1,3-dipolar cycloaddition reaction between vinylporphyrin 2 and nitrile oxides. The steric interaction directed the reaction trajectory, in which only the product with a link between the 5-position of the isoxazoline and the β-position of porphyrin was observed. The isoxazoline-porphyrins 3a,b have been characterized by absorption, emission, 1H NMR and mass spectra. Later, the crystal structure of 3a was obtained and confirmed the basic features of the NMR-derived structure. Furthermore, a pair of enantiomers of 3a present
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6

Liu, Yilin, Jiaxue Liu, Yan-Yun Liu та ін. "Synthesis of spirocyclic Δ4-isoxazolines via [3 + 2] cycloaddition of indanone-derived ketonitrones with alkynes". RSC Advances 11, № 48 (2021): 30415–25. http://dx.doi.org/10.1039/d1ra06063e.

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A [3 + 2] cycloaddition of indanone-derived nitrones with alkynes under mild conditions has been developed. It is a highly efficient and straightforward method for the synthesis of diverse spirocyclicindenyl isoxazolines.
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7

S. AL-Rawi, Muna, Huda A. Hassan, Dheefaf F. Hassan та Ismaeel Y. Majeed. "New Series of Substituted Heterocyclics Derived from α , β – Unsaturated Ketone and Their Cytotoxic Activity Tumor Cell Lines". Oriental Journal of Chemistry 34, № 6 (2018): 2826–31. http://dx.doi.org/10.13005/ojc/340620.

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The aldol condensation of 2-acetylnaphthalene with 9-anthracene carboxaldehyde afforded α, β-unsaturated keton (1) . New heterocyclic compounds containing: cyclohexenone[2], indazole[3], pyrimidinethion [4], thiazolo fused pyrimidine[5], isoxazoline[6], substituted pyrazoline[7]a-d and pyrimidinone[8] rings system were synthesized from α, β-unsaturated keton[1]. Cyclization of [1] with ethylacetoacetate gave the mentioned heterocycle cyclohexanone [2]. The cyclo condensation of [2] with hydrazine gave the new indazole derivative [3]. furthermore, the reation of [1]with thiourea gives thiopyrmi
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8

Jäger, Volker, Wolfgang Frey, Yaser Bathich, et al. "2-Isoxazolinium Salts and 3-Isoxazolines: Exploratory Chemistry and Uses for the Synthesis of Branched Amino Polyols and Amino Acids." Zeitschrift für Naturforschung B 65, no. 7 (2010): 821–32. http://dx.doi.org/10.1515/znb-2010-0708.

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2-Isoxazolines represent a well known class of heterocycles, readily accessible in particular by 1,3-dipolar cycloaddition of nitrile oxides to alkenes. 2-Isoxazolines are easily transformed into 2- isoxazolinium salts by N-methylation, and further into 3-isoxazolines by deprotonation. In contrast to the parent system, less is known concerning the chemistry of the derived classes, and potential applications in synthesis. - 2-Isoxazolinium salts, due to their iminium part, are prone to the attack of nucleophiles, and examples for this, addition of hydride (reduction) and C-nucleophiles like met
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9

Cundy, DJ, and GW Simpson. "The Cycloaddition Reactions of Benzimidazole-2-carbonitrite Oxide With Alkenes." Australian Journal of Chemistry 49, no. 2 (1996): 199. http://dx.doi.org/10.1071/ch9960199.

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Benzimidazole-2-carbonitrile oxide was prepared in situ and reacted with vinyl acetate, acrylonitrile, styrene, phenyl vinyl sulfone and 3,3,3-trifluoropropene to afford 2-(5'-acetoxyisoxazolin-3'-yl)-, 2-[(5'-cyanoisoxazolin-3'-yl)-, 2-(5'-phenylisoxazolin-3'-yl)-, 2-[(5'-phenylsulfonyl)isoxazolin-3'-yl]- and 2-[(5'- ( trifluoromethyl )isoxazolin-3'-yl)]- benzimidazole respectively. 2-(5'-Acetoxyisoxazolin-3'-yl) benzimidazole was converted into 2-(isoxazol-3'-yl) benzimidazole by treatment with triethylamine. The amidoximes derived from unsubstituted and N1-sulfamoyl-substituted 2-cyanobenzi
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10

Mukaijo, Yusuke, Soichi Yokoyama, and Nagatoshi Nishiwaki. "Comparison of Substituting Ability of Nitronate versus Enolate for Direct Substitution of a Nitro Group." Molecules 25, no. 9 (2020): 2048. http://dx.doi.org/10.3390/molecules25092048.

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α-Nitrocinnamate underwent the conjugate addition of an active methylene compound such as nitroacetate, 1,3-dicarbonyl compound, or α-nitroketone, and the following ring closure afforded functionalized heterocyclic frameworks. The reaction of cinnamate with nitroacetate occurs via nucleophilic substitution of a nitro group by the O-attack of the nitronate, which results in isoxazoline N-oxide. This protocol was applicable to 1,3-dicarbonyl compounds to afford dihydrofuran derivatives, including those derived from direct substitution of a nitro group caused by O-attack of enolate. It was found
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Dissertations / Theses on the topic "Isoxazoline derive"

1

Riss, Bernard. "Substances antiappetantes pour insectes phytophages : synthese totale de la bisabolangelone." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13030.

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Dans le cadre des substances antiappetantes pour insectes phytophages, nous presentons la premiere synthese totale de la bisabolangelone. Il s'agit d'un antiappetant sesquiterpenoide, present dans angelica silvestris. La strategie de synthese, fait appel a une reaction tres peu exploitee : l'additioon intramoleculaire d'un alcool sur une triple liaison. Cette reaction permet d'acceder au motif (methyl-3 butene-2 ylidene)-2 tetrahydrofuranne de facon stereospecifique. Dans un premier temps, l'etude d'un modele nous a permis de connaitre la versatilite et les limites d'application de cette react
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2

Becker, Tobias [Verfasser], Wilhelm [Gutachter] Boland, Georg Gutachter] Pohnert, and Wittko [Gutachter] [Francke. "3-Nitropropanoic acid and isoxazolin-5-one derived glucosides in chrysomelina larvae : synthesis, biosynthesis, occurrence and toxicity / Tobias Becker ; Gutachter: Wilhelm Boland, Georg Pohnert, Wittko Francke." Jena : Friedrich-Schiller-Universität Jena, 2017. http://d-nb.info/1177602245/34.

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