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Journal articles on the topic 'Isoxazolino'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Balalaie, Saeed, Mohammad Shamakli, Ali Nikbakht, et al. "Direct access to isoxazolino and isoxazolo benzazepines from 2-((hydroxyimino)methyl)benzoic acid via a post-Ugi heteroannulation." Organic & Biomolecular Chemistry 15, no. 27 (2017): 5737–42. http://dx.doi.org/10.1039/c7ob01142c.

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A diversity-oriented access to isoxazolino and isoxazolo benzazepines is elaborated via a post-Ugi heteroannulation involving intramolecular 1,3-dipolar cycloaddition reaction of nitrile oxides with alkenes and alkynes.

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2

Bartolotta, Roberta, Concetta La Rosa, and Donatella Nava. "New Strategy of Synthesis of Peramivir Analogues as Potential Neuraminidase Inhibitors." Synthesis 52, no. 06 (2019): 933–41. http://dx.doi.org/10.1055/s-0039-1690039.

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Highly functionalised potential neuraminidase (NA) inhibitors, analogues of peramivir, were synthesised via a new and versatile method starting from a stereoselective 1,3-dipolar cycloaddition reaction between the nitrile oxide derived from 2-ethylbutanal and the commercially available and inexpensive cyclopentadiene and 1,3-cyclohexadiene, which afforded the isoxazolino-cyclopentene or cyclohexene intermediates, respectively. The subsequent reaction of the C=C bond in different conditions allowed the functionalisation of the five (or six) membered carbon nucleus. Further functionalised deriva

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3

Lukevics, E., P. Arsenyan, and M. Veveris. "Synthesis, Vasodilating, Antithrombotic and Cardioprotective Activity of Pyridyl Substituted 5-Silyl(Germyl)Isoxazolines-2." Metal-Based Drugs 5, no. 4 (1998): 251–57. http://dx.doi.org/10.1155/mbd.1998.251.

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The reactions of [2+3] cycloaddition of pyridylnitrile oxides to vinyl- and allylgermanes proceed regioselectively and afford 5-Ge-substituted isoxazolines-2. We have synthesized 9 new pyridyl substituted 5-Si(Ge)-isoxazolines-2 and investigated their biological activity. The vasodilating, anticoagulant and cardioprotective activities of 5-Si(Ge) substituted isoxazolines-2 have been studied in vitro and in vivo. Substitution of the silicon atom for the germanium one leads to the significant increase in vasodilating, antithrombotic and cardioprotective activity. The insertion of the methylene g

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4

Murphy, James J., James G. Hamilton, and R. Michael Paton. "Synthesis and ring opening metathesis polymerisation of isoxazolino- and isoxazolidino-norbornenes." Polymer 47, no. 10 (2006): 3292–97. http://dx.doi.org/10.1016/j.polymer.2006.03.027.

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5

BAR, N. C., A. ROY, R. PATRA, B. ACHARI, and S. B. MANDAL. "ChemInform Abstract: Solvent and Salt Dependent 1,3-Dipolar Cycloaddition: Synthesis of Isoxazolidino- and Isoxazolino-Carbocycles." ChemInform 28, no. 34 (2010): no. http://dx.doi.org/10.1002/chin.199734147.

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6

Koroleva, E. V., and F. A. Lakhvich. "Synthesis of 13,15-isoxazolino-15-heteroaryl-prostanoids." Chemistry of Heterocyclic Compounds 30, no. 4 (1994): 458–59. http://dx.doi.org/10.1007/bf01169942.

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7

A., K. KHALAFALLAH, I. M. KORAIEM A., A. EL MAGHRABY M., and A. SHINDY H. "Synthesis and Studies on some Heterocyclic Nitrogen Compounds." Journal of Indian Chemical Society Vol. 66, June 1989 (1989): 398–400. https://doi.org/10.5281/zenodo.5995285.

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<em>Chemistry Department, Aswan Faculty of Science, Aswan, Egypt</em> <em>Manuscript received 21 July 1968, revised 10 March 1989, accepted 12 April 1989</em> <strong>C</strong>ondensation of 4,9 -dioxopiperldine[2,3-<em>g</em>]-1,2,3,4 6,7,8,9-octahydroquinolinoquinone (1) with aromatic aldehydes yielded the corresponding 3,3-bis-benzylidene derivatives (2a-f). Interaction of 2a—f with hydrazines, bydroxylamine, urea and thiourea afforded a new bis(pyrazolino-, 4a — <em>f, 5</em>a—f <em>; </em>isoxazolino- 6a — f ; pyrimidine and/or pyrimidine-thione, 7a— f,

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8

KOROLEVA, E. V., and F. A. LAKHVICH. "ChemInform Abstract: Synthesis of 13,15-Isoxazolino-15-heteroarylprostanoids (III)." ChemInform 26, no. 10 (2010): no. http://dx.doi.org/10.1002/chin.199510290.

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9

Moggio, Yuri, Laura Legnani, Bruna Bovio, Misal Giuseppe Memeo, and Paolo Quadrelli. "Synthesis of novel anthracene derivatives of isoxazolino-carbocyclic nucleoside analogues." Tetrahedron 68, no. 5 (2012): 1384–92. http://dx.doi.org/10.1016/j.tet.2011.12.047.

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10

D. Tupare, Shrikrishna, and Sanjay B. Sonawale. "Synthesis of Some Novel Isoxazoline from Sec 3-Amino Pyridazine Chalcones and Their Antimicrobial Studies." Mediterranean Journal of Basic and Applied Sciences 07, no. 01 (2023): 133–40. http://dx.doi.org/10.46382/mjbas.2023.7110.

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Different novel isoxazolines were synthesized by the cyclization of secondary amino derivatives with pyridazine as a substituted intermediate in the presence of hydroxylamine hydrochloride. Isoxazoline is an important class of nitrogen and oxygen-containing five-membered heterocyclic compounds having great medicinal importance. Many heterocyclic, pharmaceutically active compounds have been synthesized using it as an intermediate. Due to this activity, it is found useful in the treatment of anti-fungal, anti-bacterial, anti-cancer, anti-amoebic, and anti-inflammatory agents. The structures of t

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11

Shrikrishna, D. Tupare, and B. Sonawale Sanjay. "Synthesis of Some Novel Isoxazoline from Sec 3-Amino Pyridazine Chalcones and Their Antimicrobial Studies." Mediterranean Journal of Basic and Applied Sciences (MJBAS) 7, no. 1 (2023): 133–40. https://doi.org/10.46382/MJBAS.2023.7110.

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Different novel isoxazolines were synthesized by the cyclization of secondary amino derivatives with pyridazine as a substituted intermediate in the presence of hydroxylamine hydrochloride. Isoxazoline is an important class of nitrogen and oxygen-containing five-membered heterocyclic compounds having great medicinal importance. Many heterocyclic, pharmaceutically active compounds have been synthesized using it as an intermediate. Due to this activity, it is found useful in the treatment of anti-fungal, anti-bacterial, anti-cancer, anti-amoebic, and anti-inflammatory agents. The structures of t

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12

Memeo, Misal Giuseppe, Francesco Lapolla, Giovanni Maga, and Paolo Quadrelli. "Synthesis and antiviral activity of anthracene derivatives of isoxazolino-carbocyclic nucleoside analogues." Tetrahedron Letters 56, no. 15 (2015): 1986–90. http://dx.doi.org/10.1016/j.tetlet.2015.02.114.

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13

Wang, Xiyue, Qingyun Hu, Hui Tang, and Xinhui Pan. "Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review." Pharmaceuticals 16, no. 2 (2023): 228. http://dx.doi.org/10.3390/ph16020228.

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Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for developing novel drug candidates. Over 80 molecules with a broad range of bioactivities, including antitumor, antibacterial, anti-inflammatory, antidiabetic, cardiovascular, and other activities, were reviewed. A review of recent studies on the use of isoxazoles and isoxazolines moiety derivative activities for natural products is presented here, focusing on the parameters that affect the bioactivity of these compounds.

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14

Martín, Nazario, Margarita Altable, Salvatore Filippone, et al. "Highly Efficient Retro-cycloaddition Reaction of Isoxazolino[4,5:1,2][60]- and -[70]fullerenes." Journal of Organic Chemistry 72, no. 10 (2007): 3840–46. http://dx.doi.org/10.1021/jo070161m.

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15

Sukhorukov, Alexey, Petr Zhmurov, Pavel Ushakov, Roman Novikov, and Sema Ioffe. "A Novel Entry to 3,4,5-Trisubstituted 2-Pyrrolidones from Isoxazoline-N-oxides." Synlett 29, no. 14 (2018): 1871–74. http://dx.doi.org/10.1055/s-0037-1610213.

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A novel strategy for the synthesis of stereochemically defined 3,4,5-trisubstituted 2-pyrrolidones was developed. The suggested approach involves reductive domino-type recyclization of 3-aminomethyl-substituted isoxazolines as a key stage. The latter are prepared via α-C–H functionalization of readily available isoxazoline-N-oxides.

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16

Sedenkova, Kseniya N., Artem S. Sazonov, Dmitry A. Vasilenko, et al. "3-[N,N-Bis(sulfonyl)amino]isoxazolines with Spiro-Annulated or 1,2-Annulated Cyclooctane Rings Inhibit Reproduction of Tick-Borne Encephalitis, Yellow Fever, and West Nile Viruses." International Journal of Molecular Sciences 24, no. 13 (2023): 10758. http://dx.doi.org/10.3390/ijms241310758.

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Spirocyclic compounds containing heterocyclic moieties represent promising 3D scaffolds for modern drug design. In the search for novel anti-flaviviral agents, we have obtained a series of 3-[N,N-bis(sulfonyl)amino]isoxazolines containing spiro-annulated cyclooctane rings and assessed their antiviral activity against tick-borne encephalitis (TBEV), yellow fever (YFV), and West Nile (WNV) viruses. The structural analogs of spirocyclic compounds with a single sulfonyl group or 1,2-annulated cyclooctane ring were also investigated. Almost all the studied 3-[N,N-bis(sulfonyl)amino]isoxazolines rev

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17

Ouzounthanasis, Konstantinos A., Jasmina Glamočlija, Ana Ćirić, and Alexandros E. Koumbis. "Studies of the Synthesis of Fused Isoxazoline/Isoquinolinones and Evaluation of the Antifungal Activity of Isoxazole-like Benzamide and Isoquinolinone Hybrids." Molecules 30, no. 3 (2025): 589. https://doi.org/10.3390/molecules30030589.

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Isoxazole derivatives (isoxazoles, isoxazolines, and isoxazolidines) are present in the structure of several natural products and/or pharmaceutically interesting compounds. In this work, a synthetic study for the preparation of fused isoxazoline/isoquinolinone hybrids is presented. The initial approach involving the sequential 1,3-dipolar cycloaddition of nitrile oxides to indenone (to obtain the isoxazoline ring) and a Beckmann rearrangement (to construct the isoquinolinone lactam system) was complicated by the formation of fragmentation products during the latter. Therefore, the desired hybr

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18

Shah, Tejaskumar, and Vikas Desai. "Synthesis and antibacterial studies of some novel isoxazoline derivatives." Journal of the Serbian Chemical Society 72, no. 5 (2007): 443–49. http://dx.doi.org/10.2298/jsc0705443s.

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A series of 3-[3-(2,4-dichloro-5-fluorophenyl)-5-(2-furyl)-4,5-dihydro-1H-pyrazol- 1-yl]-5-(substituted phenyl/2-thienyl)isoxazolines (4a-j) were prepared. The structures of the isoxazoline derivatives were confirmed on the bases of elemental analysis and spectral data. The compounds were screened for their in vitro antibacterial activity using gram-positive bacteria and gram-negative bacteria.

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19

Soufiaoui, M., B. Syassi, B. Daou, and N. Baba. "Synthèse “One-Pot” de Dérivés Halogénés du 4,4-Dioxyde isoxazolino-[4,5-b]benzo[b]thiophènes." Tetrahedron Letters 32, no. 30 (1991): 3699–700. http://dx.doi.org/10.1016/s0040-4039(00)79771-1.

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20

Memeo, Misal Giuseppe, Mariella Mella та Paolo Quadrelli. "The Chemoselective Reduction of Isoxazolineγ-Lactams Through Iminium Aza-Diels-Alder Reactions: A Short-Cut Synthesis of Aminols as Valuable Intermediates towards Nucleoside Derivatives". Scientific World Journal 2012 (2012): 1–10. http://dx.doi.org/10.1100/2012/643647.

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Isoxazolineγ-lactams are prepared starting from the regioisomeric cycloadducts of benzonitrile oxide to theN-alkyl 2-azanorbornenes taking advantage of the efficient catalytic oxidation by RuO4. The reduction of the amide groups is easily conducted in the presence of LiAlH4under mild conditions, which allowed for the chemoselective reduction of the amide moiety followed by ring opening to afford the desired conformationally locked isoxazoline-carbocyclic aminols, as valuable intermediates for nucleoside synthesis.

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21

Phanumartwiwath, Anuchit, Chatchai Kesornpun, Sanya Sureram, et al. "Antitubercular and antibacterial activities of isoxazolines derived from natural products: Isoxazolines as inhibitors of Mycobacterium tuberculosis InhA." Journal of Chemical Research 45, no. 11-12 (2021): 1003–15. http://dx.doi.org/10.1177/17475198211047801.

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Isoxazoline derivatives of the natural products eugenol, 1’- S-acetoxychavicol acetate and sclareol are prepared through 1,3-dipolar cycloaddition reactions in an aqueous buffered system. The compounds are evaluated for their antitubercular and antibacterial activities. Compounds 2, 2a and 3f display strong antitubercular activity with minimum inhibitory concentration values of 26.68, 17.89 and 14.58 µM, respectively. Furthermore, derivative 3f exhibits antibacterial activity against Bacillus cereus (minimum inhibitory concentration value of 29.16 µM). Isoxazoline derivatives of 1’- S-acetoxyc

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22

Krompiec, Stanisław, Piotr Lodowski, Aneta Kurpanik-Wójcik, et al. "Nitrile Oxide, Alkenes, Dipolar Cycloaddition, Isomerization and Metathesis Involved in the Syntheses of 2-Isoxazolines." Molecules 28, no. 6 (2023): 2547. http://dx.doi.org/10.3390/molecules28062547.

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The involvement of 1,3-dipolar cycloaddition (1,3-DP), double bond migration, metathesis, and nitrile oxide (including in situ-generated nitrile oxide) as dipoles, together with the C=C bond containing dipolarophiles, in the syntheses of 2-isoxazolines is presented. Methods for synthesizing isoxazolines (other than 1,3-DP cycloaddition) were also presented briefly. Various methods of nitrile oxide preparation, especially in situ-generated procedures, are presented. Special attention was paid to the application of various combinations of 1,3-DP cycloaddition with double bond migration (DBM) and

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23

Cox, Matthew, Saba Jahangiri, Michael V. Perkins, and Rolf H. Prager. "Some Synthetic Approaches to Glutamate AMPA Receptor Agonists Based on Isoxazolones." Australian Journal of Chemistry 57, no. 7 (2004): 685. http://dx.doi.org/10.1071/ch04041.

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Several approaches to the synthesis of derivatives of the antifungal antibiotic TAN-950A, which is also an agonist of glutamate at hippocampal neurons, are reported. Additions of isoxazolon-4-yl anions to methyleneoxazolidinones were not useful because addition occurred predominantly through N-2. Similarly addition of the isoxazolon-4-yl radicals to model Michael acceptors occurred predominantly through N-2. Racemic analogues of TAN-950A were prepared by reaction of isoxazolone Mannich bases with acetylaminomalonate or addition of β-ketoester anions to dehydroalanines. The best approach to ena

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24

Knapp, John M., Jie S. Zhu, Alex B. Wood та Mark J. Kurth. "Expedient Synthesis of a 72-Membered Isoxazolino-β-ketoamide Library by a 2·3-Component Reaction". ACS Combinatorial Science 14, № 2 (2012): 85–88. http://dx.doi.org/10.1021/co200199h.

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25

Zhou, Tianhao, Weiping Wu, Suhan Ma, Jie Chen, Jia Huang, and Xiaomu Qiao. "Effects of RDL GABA Receptor Point Mutants on Susceptibility to Meta-Diamide and Isoxazoline Insecticides in Drosophila melanogaster." Insects 15, no. 5 (2024): 334. http://dx.doi.org/10.3390/insects15050334.

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Ionotropic γ-aminobutyric acid (GABA) receptors in insects, specifically those composed of the RDL (resistant to dieldrin) subunit, serve as important targets for commonly used synthetic insecticides. These insecticides belong to various chemical classes, such as phenylpyrazoles, cyclodienes, meta-diamides, and isoxazolines, with the latter two potentially binding to the transmembrane inter-subunit pocket. However, the specific amino acid residues that contribute to the high sensitivity of insect RDL receptors to these novel insecticides remain elusive. In this study, we investigated the susce

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26

Cao, Jian-Kang, Tian-Zheng Cao, Qian-Wen Yue, et al. "tert-Butyl Nitrite-Induced Radical Nitrile Oxidation Cycloaddition: Synthesis of Isoxazole/Isoxazoline-Fused Benzo 6/7/8-membered Oxacyclic Ketones." Molecules 29, no. 6 (2024): 1202. http://dx.doi.org/10.3390/molecules29061202.

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A practical metal-free and additive-free approach for the synthesis of 6/7/8-membered oxacyclic ketone-fused isoxazoles/isoxazolines tetracyclic or tricyclic structures is reported through Csp3–H bond radical nitrile oxidation and the intramolecular cycloaddition of alkenyl/alkynyl-substituted aryl methyl ketones. This convenient approach enables the simultaneous formation of isoxazole/isoxazoline and 6/7/8-membered oxacyclic ketones to form polycyclic architectures by using tert-butyl nitrite (TBN) as a non-metallic radical initiator and N–O fragment donor.

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27

El Idrissi, Mohammed, Mohamed El Ghozlani, Asli Eşme, et al. "Mpro-SARS-CoV-2 Inhibitors and Various Chemical Reactivity of 1-Bromo- and 1-Chloro-4-vinylbenzene in [3 + 2] Cycloaddition Reactions." Organics 2, no. 1 (2021): 1–16. http://dx.doi.org/10.3390/org2010001.

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The regioselectvity and the mechanism of the (32CA) cycloadditions reactions of 1-bromo-4-vinylbenzene 1 and 1-chloro-4-vinylbenzene 2 with benzonitrile oxide 3 were investigated under the molecular electron density theory (MEDT) at the B3LYP/6-311++G(d,p) computational level. Evaluation of the ELF reveals that these zwitterionic type (zw-type) 32CA reactions take place in a two-stage one-step mechanism. This MEDT study shows that the meta isoxazolines are kinetically and thermodynamically favored over the ortho ones, these 32CA reactions being completely regioselective, in agreement with expe

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28

SOUFIAOUI, M., B. SYASSI, B. DAOU, and N. BABA. "ChemInform Abstract: One-Pot Synthesis of Halogen Derivatives of Isoxazolino(4,5-b)benzo(b) thiophene 4,4-Dioxide." ChemInform 23, no. 18 (2010): no. http://dx.doi.org/10.1002/chin.199218189.

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29

Eddaif, A., S. Kitane, M. Soufiaoui, and P. Mison. "Cycloaddition dipolaire −1,3 sur des 2H-pyrroles: synthèse de quelques dérivés de pyrazolino- et isoxazolino- [5,6-e] pyrroles." Tetrahedron Letters 32, no. 30 (1991): 3709–10. http://dx.doi.org/10.1016/s0040-4039(00)79774-7.

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30

Cabrera-Espinoza, Andrea, Braulio Insuasty, and Alejandro Ortiz. "Novel BODIPY-C60 derivatives with tuned photophysical and electron-acceptor properties: Isoxazolino[60]fullerene and pyrrolidino[60]fullerene." Journal of Luminescence 194 (February 2018): 729–38. http://dx.doi.org/10.1016/j.jlumin.2017.09.043.

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31

Nagireddy, Jaipal R., Emily Carlson, and William Tam. "1,3-Dipolar cycloaddition of nitrile oxides with C1-substituted 7-oxabenzonorbornadienes." Canadian Journal of Chemistry 92, no. 11 (2014): 1053–58. http://dx.doi.org/10.1139/cjc-2014-0274.

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1,3-Dipolar cycloadditions of unsymmetrical C1-substituted 7-oxabenzonorbornadienes with acetonitrile oxide and benzonitrile oxide were investigated to probe the regio- and stereoselectivities of these reactions. All novel oxabicycle-fused isoxazoline adducts were obtained in moderate to excellent yields (53%–98%) and with complete exo-stereoselectivity. The major regioisomer in almost all instances showed positioning of the nitrile oxide’s methyl or phenyl group anti to the C1-substituent. The relative ratios of the regioisomers suggested nonnegligible electronic and steric contributions of t

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32

EDDAIF, A., S. KITANE, M. SOUFIAOUI, and P. MISON. "ChemInform Abstract: 1,3-Dipolar Cycloaddition Reaction with 2H-Pyrroles: Synthesis of Some Pyrazolino- and Isoxazolino(5,6-e)pyrrole Derivatives." ChemInform 23, no. 18 (2010): no. http://dx.doi.org/10.1002/chin.199218076.

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33

Ghodile, Nitin Gopalsing, and M. W. Bhade. "Synthesis and Characterization of Some Chlorosubstituted Azoles and their Screening Against Some Mushroom Crop Pathogens and Study of their Efficacy on Growth of Oyster Mushroom spp." Current Agriculture Research Journal 11, no. 3 (2024): 955–60. http://dx.doi.org/10.12944/carj.11.3.24.

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Applicability of azoles possessing nitrogen and oxygen atom as a heteroatom are well known in the fields of agriculture, medicine, and industries. One of the fast-growing research areas in the heterocyclic chemistry has been directed towards the synthesis of isoxazoline derivatives; as a structural unit frequently found in natural products and many bioactive molecules. They exhibit various biological activities. Isoxazoline having Imidazole moiety have been reported as an ingredient of various pesticides useful for the control of pest in agriculture arena. Some derivatives exhibit antimicrobia

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34

Journal, Baghdad Science. "Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial Agents." Baghdad Science Journal 13, no. 3 (2016): 568–77. http://dx.doi.org/10.21123/bsj.13.3.568-577.

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In this paper some chalcones (C1-C8) are prepared based on the reaction of one mole of substituted acetophenone with one mole of substituted benzaldehydes in the presence of (40%) sodium hydroxide as a base. Pyrazolines (P1–P8) are prepared from the reaction of chalcones (C1-C8) with hydrazine hydrate. Isoxazoline (I1-I8) is prepared from the reaction of chalcones (C1-C8) with hydroxyl amine hydrochloride in the presence of (10%) sodium hydroxide as a base. These compounds are characterized by using various physical and spectral methods. The compounds are screened for their in vitro antibacter

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35

Memeo, Misal Giuseppe, Bruna Bovio та Paolo Quadrelli. "RuO4-catalyzed oxidation reactions of isoxazolino-2-azanorbornane derivatives: a short-cut synthesis of tricyclic lactams and peptidomimetic γ-amino acids". Tetrahedron 67, № 10 (2011): 1907–14. http://dx.doi.org/10.1016/j.tet.2011.01.014.

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36

Lamassiaude, Nicolas, Berthine Toubate, Cédric Neveu, et al. "The molecular targets of ivermectin and lotilaner in the human louse Pediculus humanus humanus: New prospects for the treatment of pediculosis." PLOS Pathogens 17, no. 2 (2021): e1008863. http://dx.doi.org/10.1371/journal.ppat.1008863.

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Control of infestation by cosmopolitan lice (Pediculus humanus) is increasingly difficult due to the transmission of parasites resistant to pediculicides. However, since the targets for pediculicides have no been identified in human lice so far, their mechanisms of action remain largely unknown. The macrocyclic lactone ivermectin is active against a broad range of insects including human lice. Isoxazolines are a new chemical class exhibiting a strong insecticidal potential. They preferentially act on the γ-aminobutyric acid (GABA) receptor made of the resistant to dieldrin (RDL) subunit and, t

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37

Sączewski, Jarosław, Joanna Fedorowicz, Paulina Wiśniewska, and Maria Gdaniec. "Theoretical and Experimental Insights into the Tandem Mannich—Electrophilic Amination Reaction: Synthesis of Safirinium Dyes." Applied Sciences 11, no. 12 (2021): 5498. http://dx.doi.org/10.3390/app11125498.

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Isoxazolo[3,4-b]pyridin-3(1H)-ones are ‘spring-loaded’ compounds that quantitatively react with iminium salts derived from formaldehyde and secondary amines to yield fluorescent Safirinium dyes. The mechanism and energetics of the above tandem Mannich–electrophilic amination reaction have been investigated experimentally and using theoretical methods. The hybrid B3LYP functional with GD3 empirical dispersion and range-separated hybrid functional ωB97XD, both combined with a PCM model, were applied to acquire the energetic profiles of the studied reaction with respect to the structure of second

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38

Sammelson, Robert E., Chamindra D. Gurusinghe, Jeffrey M. Kurth, Marilyn M. Olmstead, and Mark J. Kurth. "Synthesis of Spiro-Fused (C5)-Isoxazolino-(C4)-pyrazolones (1-Oxa-2,7,8-triazaspiro[4,4]-2,8-dien-6-ones) via 1,3-Dipolar Cycloaddition and Cycloelimination." Journal of Organic Chemistry 67, no. 3 (2002): 876–82. http://dx.doi.org/10.1021/jo010895d.

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39

Kaur, Manvinder, Mohamad Yusuf, Dharambeer Singh Malhi, and Harvinder Singh Sohal. "Bis-dihydroisoxazolines: Synthesis, Structural Elucidation, Antimicrobial Evaluation, and DNA Photocleavage Assay." Current Organic Synthesis 17, no. 8 (2020): 671–78. http://dx.doi.org/10.2174/1570179417666200713181959.

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Aim and Objective: Isoxazole is an active core found in many drugs. The aim of this work was to synthesize bis-isoxazoline compounds and to analyze the effect of linker chain length on biological activities. Material and Methods: A simple, convenient, and efficient method for the conversion of bischalcones to new bis(4,5-dihydroisoxazole) derivatives was developed by using hydroxylamine hydrochloride under basic medium. Synthesized moieties were also evaluated for their antimicrobial potencies and DNA photocleavage assay. Results and Discussion: The synthesized compounds were more active than

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Ciura, Krzesimir, Joanna Fedorowicz, Hanna Kapica, Monika Pastewska, Wiesław Sawicki, and Jarosław Sączewski. "Interaction between Antifungal Isoxazolo[3,4-b]Pyridin 3(1H)-One Derivatives and Human Serum Proteins Analyzed with Biomimetic Chromatography and QSAR Approach." Processes 9, no. 3 (2021): 512. http://dx.doi.org/10.3390/pr9030512.

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The development of effective, nontoxic antifungal agents is one of the most important challenges for medicinal chemistry. A series of isoxazolo [3,4-b]pyridine-3(1H)-one derivatives previously synthesized in our laboratory demonstrated promising antifungal properties. The main goal of this study was to investigate their retention behavior in a human serum proteins-high-performance liquid chromatography (HSA-HPLC) system and explore the molecular mechanism of HSA-isoxazolone interactions using a quantitative structure–retention relationship (QSRR) approach. In order to realize this goal, multip

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Sammelson, Robert E., Chamindra D. Gurusinghe, Jeffrey M. Kurth, Marilyn M. Olmstead, and Mark J. Kurth. "ChemInform Abstract: Synthesis of Spiro-Fused (C5)-Isoxazolino-(C4)-pyrazolones (1-Oxa-2,7,8-triazaspiro[4,4]-2,8-dien-6-ones) via 1,3-Dipolar Cycloaddition and Cycloelimination." ChemInform 33, no. 30 (2010): no. http://dx.doi.org/10.1002/chin.200230162.

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Abbiati, Giorgio, Antonio Arcadi, Fabio Marinelli, Elisabetta Rossi та Mirella Verdecchia. "Sequential 1,3-Dipolar Cycloaddition of Nitrones to β-(2-Aminophenyl) α,β-Ynones and Cyclocondensation: A New Entry to the Isoxazolino[4,5-c]quinoline Ring". European Journal of Organic Chemistry 2009, № 7 (2009): 1027–31. http://dx.doi.org/10.1002/ejoc.200800994.

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Chew, Renta Jonathan, та Martin Wills. "Ruthenium-Catalyzed Asymmetric Reduction of Isoxazolium Salts: Access to Optically Active Δ4-Isoxazolines". Journal of Organic Chemistry 83, № 5 (2018): 2980–85. http://dx.doi.org/10.1021/acs.joc.7b03229.

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D. Mosher, Michael. "Non-dipolar Cyclization Methods for the Preparation of 2-isoxazolines and 2-isoxazoline N-oxides." Current Organic Synthesis 8, no. 5 (2011): 645–58. http://dx.doi.org/10.2174/157017911796957401.

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Murphy, James J., Kotohiro Nomura, and R. Michael Paton. "Synthesis of Isoxazolino Norbornene Derivatives Containing Sugar Residues by 1,3-Dipolar Cycloaddition and Their Application to the Synthesis of Neoglycopolymers by Living Ring-Opening Metathesis Polymerization." Macromolecules 39, no. 9 (2006): 3147–53. http://dx.doi.org/10.1021/ma060168q.

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Zawadzińska, Karolina, та Karolina Kula. "Application of β-Phosphorylated Nitroethenes in [3+2] Cycloaddition Reactions Involving Benzonitrile N-Oxide in the Light of a DFT Computational Study". Organics 2, № 1 (2021): 26–37. http://dx.doi.org/10.3390/org2010003.

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The regiochemistry of [3+2] cycloaddition (32CA) processes between benzonitrile N-oxide 1 and β-phosphorylated analogues of nitroethenes 2a–c has been studied using the Density Functional Theory (DFT) at the M062X/6-31+G(d) theory level. The obtained results of reactivity indices show that benzonitrile N-oxide 1 can be classified both as a moderate electrophile and moderate nucleophile, while β-phosphorylated analogues of nitroethenes 2a–c can be classified as strong electrophiles and marginal nucleophiles. Moreover, the analysis of CDFT shows that for [3+2] cycloadditions with the participati

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Becker, Tobias, Prashant Kartikeya, Christian Paetz, Stephan H. von Reuß, and Wilhelm Boland. "Synthesis and photosensitivity of isoxazolin-5-one glycosides." Organic & Biomolecular Chemistry 13, no. 13 (2015): 4025–30. http://dx.doi.org/10.1039/c5ob00244c.

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An improved synthetic protocol is described, allowing the synthesis of novel and naturally occurring isoxazolin-5-one glycosides. The photohydrolysis efficiency and pH stability of the obtained isoxazolin-5-one glycosides was studied.

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A., NAGARAJAN, and KRISHNA PILLAY M. "Electron-impact Mass Spectral Fragmentation Patterns of lsoxazolines." Journal of Indian Chemical Society Vol. 70, Feb 1993 (1993): 134–37. https://doi.org/10.5281/zenodo.5910713.

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Department of Chemistry, Bharathidasan University, Tiruchirapalli-620 024 <em>Manuscript received 12 February 1992, revised 30 October 1992, accepted 2 December 1992</em> Electron-impact mass spectra of 32 isoxazolines, viz. monocyclic, bicyclic and tricyclic isoxazolines are reported. The major fragmmtation pattern for the isoxazolines with alkyl, aryl, methoxycarbonyl, (methylthio)methyl substituents at C·5 is \(\alpha\)-cleavage while there is a competition between the groups at C-5 for elimination in the case of 5,5-disubstituted isoxazolines. Bicyclic and tricyclic isoxazolines und

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Kotwal, Urmila, Archana Tiwari, and Shweta Choudhary. "Synthesis, Characterization and Antimicrobial Activity of Isoxazoline Derivatives." International Journal of Pharmaceutical Sciences and Medicine 7, no. 11 (2022): 107–20. http://dx.doi.org/10.47760/ijpsm.2022.v07i11.008.

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In present study isoxazoline derivatives were synthesized and antimicrobial activity of different derivatives were checked with various microbial stain. Various intermediates was synthesized and characterized in between time to time by chromatography using TLC. An isoxazoline series of compounds were synthesized by condensation reaction of phenyl ethyl acetate with substituted benzaldehyde in presence of alcoholic sodium hydroxide to get intermediate phenethyl cinnamate (chalcones), which were further treated with hydroxylamine hydrochloride in presence of sodium hydroxide to get isoxazoline d

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Park, Sang Won, Soong-Hyun Kim, Jaeyoung Song, et al. "Hypervalent iodine-mediated Ritter-type amidation of terminal alkenes: The synthesis of isoxazoline and pyrazoline cores." Beilstein Journal of Organic Chemistry 14 (May 11, 2018): 1028–33. http://dx.doi.org/10.3762/bjoc.14.89.

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Hypervalent iodine-mediated olefin functionalization provides a rapid gateway towards accessing both various heterocyclic cores and functional groups. In this regard, we have developed a Ritter-type alkene functionalization utilizing a PhI(OAc)2 ((diacetoxyiodo)benzene, PIDA)/Lewis acid combination in order to access isoxazoline and pyrazoline cores. Based on allyl ketone oximes and allyl ketone tosylhydrazones, we have developed an alkene oxyamidation and amido-amidation protocol en route to accessing both isoxazoline and pyrazoline cores. Additionally, acetonitrile serves as both the solvent

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