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Paterleni, Marta. "Profile: Istituto Superiore di Sanità, Rome, Italy." Lancet 388, no. 10049 (September 2016): 1044. http://dx.doi.org/10.1016/s0140-6736(16)31498-2.
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Salmaso, S. "European Union inventory of resources and means of control of communicable diseases." Eurosurveillance 3, no. 5 (May 1, 1998): 51–2. http://dx.doi.org/10.2807/esm.03.05.00109-en.
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The Istituto Superiore di Sanità (ISS) in Rome, in collaboration with the Public Health Laboratory Service (PHLS) in London, and the Swedish Institute for Infectious Diseases Control (SIIDC) in Stockholm, is conducting a scientific and technical analysis
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Suligoi, B., C. Von Hunolstein, G. Orefici, F. Scopetti, M. Pataracchia, and D. Greco. "Surveillance of systemic invasive disease caused by group A Streptococcus in Italy 1994-1996." Eurosurveillance 3, no. 2 (February 1, 1998): 11–4. http://dx.doi.org/10.2807/esm.03.02.00117-en.
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In late May 1994, following reports of an outbreak of group A beta-haemolytic streptococcus (GAS) in the United Kingdom, the Istituto Superiore di Sanità (ISS) set up a surveillance system for systemic invasive GAS disease. The surveillance system was als
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Ricciardi, Walter, and Angelo Del Favero. "Foreword of the Commissioner and General Director of the Istituto Superiore di Sanità, Rome." European Journal of Preventive Cardiology 22, no. 2_suppl (July 20, 2015): 6. http://dx.doi.org/10.1177/2047487315591138.
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SOLIMINI, RENATA. "The participation of Istituto Superiore di Sanità in the Joint Action on Tobacco Control." Tabaccologia 19, no. 2 (August 31, 2021): 40–44. http://dx.doi.org/10.53127/tblg-2021-a017.
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Toni, Franco. "Antonio Canova’s drawings in the Rare Books Collection of the Istituto Superiore di Sanità Library (Rome, Italy)." Journal of EAHIL 15, no. 4 (December 10, 2019): 13–17. http://dx.doi.org/10.32384/jeahil15352.
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The paper aims to promote the knowledge of the extraordinary collection of anatomical subject drawings by Antonio Canova, the most important Italian neoclassic artist, owned by the National Institute of Health Library in Rome. The history of acquisition by the library and the analysis of their importance in the long career of the artist is also treated. A short story about the fortune of the drawings in the last 20 years completes the study.
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Ingrosso, Loredana, Giovanni Rezza, Maurizio Pocchiari, and Enrico Garaci. "Editorial. The CNCCS, a benchmark Italian consortium for bioeconomy and an opportunity for the Istituto Superiore di Sanità." Annali dell'Istituto Superiore di Sanità 48, no. 2 (June 2012): 115–16. http://dx.doi.org/10.4415/ann_12_02_01.
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Tomasini, I. "Overview of Plasmapheresis in Italy." International Journal of Artificial Organs 16, no. 5_suppl (May 1993): 145–48. http://dx.doi.org/10.1177/039139889301605s30.
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The national law, concerning Blood Transfusion and Blood derivatives in Italy, aims at achieving self-sufficiency and assuring safety of blood, plasma and plasma derivatives, according to EEC ((EE-Directive 89/381) and to the Council of Europe (R-88/4)). According to this law it is the task of the Central National Authority, (ie Istituto Superiore di Sanità (ISS)), to coordinate the transfusion system nationwide. The adoption and the transmission to the ISS of Regional Blood Registers containing information about the local use of blood and blood derivatives is in progress. Up to now the data are collected from a network among Blood Centers by Società italiana di lm-munoematologia e Trasfusione del Sangue - Associazione Italiana Centri Trasfusionali (SIITS - AICT) and these results show that in Italy the incorrect use of plasma and albumin and the insufficient practice of plasmapheresis are the major obstacles to the achievement of self-sufficiency.
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Stammati, Annalaura, Franco Zampaglioni, and Cristiana Zanetti. "The Neutral Red Uptake Assay: Comments on the Results of the Istituto Superiore di Sanità in the EC/HO Validation Study." Alternatives to Laboratory Animals 26, no. 1 (January 1998): 61–68. http://dx.doi.org/10.1177/026119299802600110.
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The neutral red uptake (NRU) assay was included, among others, in a validation study sponsored by the European Commission/British Home Office (EC/HO) study, for its reliability as an in vitro alternative to the Draize eye irritancy test. The test was performed in parallel by four laboratories (Istituto Superiore di Sanità [ISS], Microbiological Associates, Hatano Research Institute and Kurabo Industries) on 60 selected chemicals. The results obtained by the ISS are reported in this paper. A poor rank correlation was obtained between the in vivo endpoint and the ISS in vitro results for the full set of chemicals and for the subsets, with the exception of surfactants, by an independent statistics group. The same unsatisfactory results were obtained by the ISS group when the rank correlation was calculated for compounds divided into chemical groups. The performance of the NRU assay, as an alternative to the Draize eye irritancy test, is discussed.
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Losavio, Tommaso. "Postfazione." Epidemiologia e psichiatria sociale. Monograph Supplement 11, S4 (March 2002): 69–72. http://dx.doi.org/10.1017/s1827433100000563.
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Indagini condotte in diverse città italiane rilevano che i cittadini stranieri utilizzano i servizi del SSN in modo proporzionalmente più basso al confronto con quello della popolazione autoctona (AA.VV. La salute straniera: Epidemiologia, culture, diritti, ESI, Napoli, 1994).Una ricerca concernente la città di Torino ha documentato in effetti come solo il 50% dei cittadini stranieri residenti ed aventi pertanto diritto risultava regolarmente iscritto al Servizio Sanitario Nazionale (Città di Torino, Osservatorio statistico provinciale sugli stranieri, Ufficio di Statistica, Torino: 1998)I flussi migratori, che in modo particolare in questi ultimi anni hanno interessato il nostro Paese, contribuiscono a modificare l'assetto sociale, economico e culturale della società italiana ed anche i modelli di organizzazione e funzionamento dei servizi socio-sanitari.Come scrive Roberto Beneduce “…sollecitare il riconoscimento dei diritti, incoraggiare l'integrazione e la conoscenza reciproca di gruppi e cittadini, disegnare strategie di intervento e di prevenzione più adeguate in relazione agli specifici modelli di malattia e bisogni di cura, diventano obiettivi che qualsiasi azione di promozione della salute nella popolazione immigrata dovrebbe riuscire a perseguire unitariamente” (Beneduce R., Frigessi D., Vacchiano F., L'attività del Centro Frantz Fanon nell'assistenza psichiatrica agli immigrati, PNSM, Istituto Superiore di Sanità, Roma 2000).
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Mannino, D. "ISS (Istituto Superiore di Sanità) and AMD (Associazione Medici Diabetologi) – an alliance for the enhancement of telemedicine in diabetology." Journal of AMD 21, no. 2 (September 2018): 82. http://dx.doi.org/10.36171/jamd18.21.2.02.
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Cassone, Antonio. "Italian Ministry of Health and the Istituto Superiore Di Sanita: from vigilance to ownership?" Pathogens and Global Health 109, no. 4 (May 11, 2015): 163–65. http://dx.doi.org/10.1179/2047772415z.000000000256.
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Masala, Giovanni, Giuseppina Cannas, and Marco Micocci. "Survival probabilities for HIV infected patients through semi-Markov processes." Biometrical Letters 51, no. 1 (June 1, 2014): 13–36. http://dx.doi.org/10.2478/bile-2014-0002.
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SUMMARY In this paper we apply a parametric semi-Markov process to model the dynamic evolution of HIV-1 infected patients. The seriousness of the infection is rendered by the CD4+ T-lymphocyte counts. For this purpose we introduce the main features of nonhomogeneous semi-Markov models. After determining the transition probabilities and the waiting time distributions in each state of the disease, we solve the evolution equations of the process in order to estimate the interval transition probabilities. These quantities appear to be of fundamental importance for clinical predictions. We also estimate the survival probabilities for HIV infected patients and compare them with respect to certain categories, such as gender, age group or type of antiretroviral therapy. Finally we attach a reward structure to the aforementioned semi-Markov processes in order to estimate clinical costs. For this purpose we generate random trajectories from the semi-Markov processes through Monte Carlo simulation. The proposed model is then applied to a large database provided by ISS (Istituto Superiore di Sanità, Rome, Italy), and all the quantities of interest are computed.
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Gradoni, L., R. Pizzuti, L. di Martino, M. Gramiccia, R. Pempinello, G. B. Gaeta, M. Ferrara, S. Scotti, and S. Altieri. "The epidemiology and surveillance of visceral leishmaniasis in the Campania region of Italy. The value of zymodeme typing." Epidemiology and Infection 111, no. 2 (October 1993): 297–306. http://dx.doi.org/10.1017/s0950268800057009.
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SummaryAlthough human visceral leishmaniasis (VL) is a notifiable disease in Italy, there is evidence that the actual number of cases is far higher than that notified. A programme for active surveillance of VL in the 14 Italian endemic regions was launched by the Istituto Superiore di Sanità. We report data collected during a 3-year period of active surveillance in Campania, a south Tyrrhenian region covering 4·5% of the Italian territory. Out of 120 clinically suspected cases referred to medical and diagnostic references centres, there were 52 confirmed VL cases (17·3/year), i.e. 10-fold more than previously notified. Most of the infection sites were in rural areas or peripheral districts of towns in hilly parts of Naples province. An epidemic cluster of 10 cases was identified in a microfocus of Caserta province. The biochemical analysis of 23Leishmaniastocks showed a zymodeme composition indicating Campania as an old and well-established focus of VL. The data obtained emphasize that the present notification system for VL in Italy is inadequate.
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Migliaccio, Anna Rita, and Sjaak Philipsen. "Reflections on the European Union Eurythron Network Meeting “Molecular Control of Erythropoiesis,” September 22-23, 2005, Istituto Superiore Di Sanità, Rome, Italy." Stem Cells 24, no. 11 (November 2006): 2478–82. http://dx.doi.org/10.1634/stemcells.2006-0121.
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Barbanti, Fabrizio, and Patrizia Spigaglia. "Microbiological characteristics of human and animal isolates of Clostridioides difficile in Italy: Results of the Istituto Superiore di Sanità in the years 2006–2016." Anaerobe 61 (February 2020): 102136. http://dx.doi.org/10.1016/j.anaerobe.2019.102136.
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Salvatore, Marco, Annalisa Amato, Giovanna Floridia, Federica Censi, Gianluca Ferrari, Fabrizio Tosto, Rita Padoan, et al. "The Italian External Quality Assessment Program for Cystic Fibrosis Sweat Chloride Test: Does Active Participation Improve the Quality?" International Journal of Environmental Research and Public Health 17, no. 9 (May 4, 2020): 3196. http://dx.doi.org/10.3390/ijerph17093196.
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(1) Background: Diagnostic testing for cystic fibrosis (CF) is based on a sweat chloride test (SCT) considering the appropriate signs and symptoms of the disease and results of a gene mutation analysis. In 2014, the Istituto Superiore di Sanità (ISS) established a pilot Italian external quality assessment program for CF SCT (Italian EQA-SCT), which is now a third party service carried out by the ISS. (2) Methods: The ongoing scheme is prospective, enrollment is voluntary, and the payment of a fee is required. Results are shared through a dedicated web-facility. Assessment covers the analysis, interpretation, and reporting of results. (3) Results: Thirteen, fifteen, sixteen, and fifteen different laboratories, respectively, participated from 2015 to 2016 and from 2018 to 2019 in the Italian EQA-SCT scheme. Eleven different laboratories participated each year in all four rounds of the Italian EQA-SCT. (4) Conclusions: The overall results obtained from the laboratories participating constantly clearly show that their qualitative and quantitative performance improved significantly. This is due to the opportunity—after receiving the EQA results—to constantly review their performance and address any inconsistencies. We firmly believe that participation in the EQA program will improve the quality of participating laboratories and that EQA participation should become mandatory as a fundamental requirement for laboratory accreditation.
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Morosini, Pierluigi, Antonella Gigantesco, Angelica Mazzarda, and Loredana Gibaldi. "HoNOS-Rome: an expanded, customized, and longitudinally oriented version of the HoNOS." Epidemiologia e Psichiatria Sociale 12, no. 1 (March 2003): 53–62. http://dx.doi.org/10.1017/s1121189x00006059.
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SUMMARYAims– To clarify the acceptability, reliability and factorial validity of a new Italian version of the HoNOS called HoNOS-Rome. Its main innovations are both in design and in contents.Methods– Face validity was assessed by surveying 3 focus groups. Reliability was assessed in 8 different pairs of raters on a sample of 24 patients; construct validity was analysed by factor analysis using a sample of 187 patients at 6 day centres. Acceptability was investigated by means an anonymous questionnaire filled by professionals that were using the instrument.Results– Time of completion was low (range 4–12 minutes), the tool proved very acceptable and the reliability was good (weighted kappa ≥ 0.71 for all items). Factor analysis was consistent with the division of HoNOS–Rome into four sensible factors accounting for 52% of the total variance.Conclusions– The findings indicate that HoNOS–Rome has a satisfactory degree of acceptability, construct validity and reliability, and may promote the routine evaluation of outcomes in mental health services.Declaration of Interest: the authors declare that the study was supported by grant no. 96/Q/T41 of the Italian National Mental Health Project – Istituto Superiore di Sanità – Sub-project: Development and validation of tools for outcome evaluation of mental health services, Italy (Professor P. Morosini).
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Censi, F., F. Tosto, G. Floridia, M. Marra, M. Salvatore, A. M. Baffico, M. Grasso, et al. "The Italian National External Quality Assessment Program in Molecular Genetic Testing: Results of the VII Round (2010-2011)." BioMed Research International 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/739010.
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Since 2001 the Istituto Superiore di Sanità established a quality assurance programme for molecular genetic testing that covers four pathologies: Cystic Fibrosis (CF), Beta Thalassemia (BT), Fragile X Syndrome (FX), and Familial Adenomatous Polyposis Coli (APC). Since 2009 this activity is an institutional activity and participation is open to both public and private laboratories. Seven rounds have been performed until now and the eighth is in progress. Laboratories receive 4 DNA samples with mock clinical indications. They analyze the samples using their routine procedures. A panel of assessors review the raw data and the reports; all data are managed through a web utility. In 2010 the number of participants was 43, 17, 15, 5 for CF, BT, FX, APC schemes respectively. Genotyping results were correct in 96%, 98.5%, 100%, and 100% of CF, BT, FX, and APC samples, respectively. Interpretation was correct in 74%, 91%, 88%, and 60% of CF, BT, FX, and APC reports, respectively; however in most of them it was not complete but a referral to genetic counseling was given. Reports were satisfactory in more than 60% of samples in all schemes. This work presents the 2010 results in detail comparing our data with those from other European schemes.
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Di Nicola, Massimo, Roberta Zappasodi, Carmelo Carlo-Stella, Roberta Mortarini, Serenella M. Pupa, Michele Magni, Liliana Devizzi, et al. "Vaccination with autologous tumor-loaded dendritic cells induces clinical and immunologic responses in indolent B-cell lymphoma patients with relapsed and measurable disease: a pilot study." Blood 113, no. 1 (January 1, 2009): 18–27. http://dx.doi.org/10.1182/blood-2008-06-165654.
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Abstract Eighteen relapsed patients with measurable indolent non-Hodgkin lymphoma (NHL) were vaccinated with dendritic cells (DCs) loaded with killed autologous tumor cells. Six patients had objective clinical responses including 3 continuous complete responses (CRs) and 3 partial responses (PRs), with a median follow up of 50.5 months. Eight patients had stable disease, whereas 4 had progressive disease. Clinical responses were significantly associated with a reduction in CD4+CD25+FOXP3+ regulatory T cells, an increase in CD3−CD56dimCD16+ natural killer (NK) cells, and maturation of lymphocytes to the effector memory stage in either postvaccination peripheral blood or tumor specimen samples. In partial responding patients, vaccination significantly boosted the IFN-γ–producing T-cell response to autologous tumor challenge. In one HLA-A*0201+ patient who achieved CR, IL-4 release by circulating T cells in response to tumor-specific IgH-encoded peptides was also documented. Immunohistochemical analysis of tumor biopsies using biotin-conjugated autologous serum samples revealed a tumor-restricted humoral response only in the postvaccination serum from responding patients. Collectively these results demonstrate that vaccination with tumor-loaded DCs may induce both T- and B-cell responses and produces clinical benefits in indolent NHL patients with measurable disease. This study is registered with the Istituto Superiore di Sanità: http://www.iss.it with protocol number 7578-PRE 21-801.
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Barbaro, V., M. Grigioni, C. Daniele, G. D'avenio, and G. Boccanera. "19 mm Sized Bileaflet Valve Prostheses’ flow Field Investigated by Bidimensional Laser Doppler Anemometry (part II: Maximum Turbulent Shear Stresses)." International Journal of Artificial Organs 20, no. 11 (November 1997): 629–36. http://dx.doi.org/10.1177/039139889702001106.
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The investigation of the flow field generated by cardiac valve prostheses is a necessary task to gain knowledge on the possible relationship between turbulence-derived stresses and the hemolytic and thrombogenic complications in patients after valve replacement. The study of turbulence flows downstream of cardiac prostheses, in literature, especially concerns large-sized prostheses with a variable flow regime from very low up to 6 L/min. The Food and Drug Administration draft guidance requires the study of the minimum prosthetic size at a high cardiac output to reach the maximum Reynolds number conditions. Within the framework of a national research project regarding the characterization of cardiovascular endoprostheses, an in-depth study of turbulence generated downstream of bileaflet cardiac valves is currently under way at the Laboratory of Biomedical Engineering of the Istituto Superiore di Sanità. Four models of 19 mm bileaflet valve prostheses were used: St Jude Medical HP, Edwards Tekna, Sorin Bicarbon, and CarboMedics. The prostheses were selected for the nominal Tissue Annulus Diameter as reported by manufacturers without any assessment of valve sizing method, and were mounted in aortic position. The aortic geometry was scaled for 19 mm prostheses using angiographic data. The turbulence-derived shear stresses were investigated very close to the valve (0.35 D0), using a bidimensional Laser Doppler anemometry system and applying the Principal Stress Analysis. Results concern typical turbulence quantities during a 50 ms window at peak flow in the systolic phase. Conclusions are drawn regarding the turbulence associated to valve design features, as well as the possible damage to blood constituents.
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Ferrantini, Maria, Claudio Lombardo, Franca Moretti, and Filippo Belardelli. "Biotherapy of Cancer: Break the Barriers to Foster Translation oF knowledge." Tumori Journal 94, no. 2 (March 2008): 182–88. http://dx.doi.org/10.1177/030089160809400209.
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Biotherapy of cancer holds great promise for its potential to lead to the identification of novel, selective, and effective treatments against cancer. However, the clinical development of biopharmaceuticals and biotherapy products is hampered by several and diverse barriers. Herein, we will address some of the critical issues identified both at the national and European level as the major obstacles for the translation of knowledge into clinical applications in the field of biotherapy and immunotherapy of cancer. We will also illustrate specific initiatives undertaken both in Europe and in Italy in order to support the translational and clinical research and that are expected to have a favorable impact on the process of clinical development of novel and more effective therapeutic interventions against cancer. The contents of this article are directly referred to the event “International Clinical Trials’ Day on Biotherapy of Cancer” organized in the context of the OECI Genoa 2008, with the sponsorship of Alliance Against Cancer (ACC) and the Istituto Superiore di Sanità (ISS, the Italian National Institute of Health), and under the auspices of the European Clinical Research Infrastructures Network (ECRIN). This event sees the active participation of representatives of the ISS and of the Italian Network for Tumor Biotherapy, both involved in a project recently funded by ACC and aimed at the promotion of clinical research in the field of cancer biotherapy and immunotherapy, through the creation of a national network of clinical cancer research centers and GMP facilities dedicated to the production of biological drugs and advanced medicinal products.
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Bucciardini, Raffaella, Rita Maria Ferrelli, Anna Maria Giammarioli, Emanuela Bortolin, Emanuele Fanales Belasio, Benedetta Mattioli, Chiara Donfrancesco, et al. "Health inequalities: a Research Positioning Exercise at the National Institute of Health, Italy." European Journal of Public Health 29, no. 5 (June 20, 2019): 943–47. http://dx.doi.org/10.1093/eurpub/ckz115.
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Abstract Background The Italian National Institute of Health (Istituto Superiore di Sanità, ISS) considers health inequalities (HI) an important area of activity. As the scientific and technical body of the Ministry of Health and the National Health Service, ISS may play a key role to reduce HI. In order to enable ISS in addressing the new and crucial HI challenge, a Research Positioning Exercise was designed and implemented. Methods The Exercise included: (i) workshop to strengthen the institutional interest in the field of HI; (ii) review and analysis of ISS publications (years 2000–2017) to identify HI research topics; (iii) survey among ISS researchers regarding main research challenges to address HI in the coming years; and (iv) analysis of input on research challenges from HI international experts. Results The results of this Exercise suggest that the following points should be included in the future ISS agenda planning: (i) themes which ISS should continue working on (e.g. migrants/vulnerable groups); (ii) themes to be improved: (a) relationship between social determinants and mechanism of HI generation and (b) relationship between risk factors exposure and social determinants; and (iii) new themes to be addressed: (a) mechanisms underlying the resilience observed in Italy; (b) new socioeconomic indicators for HI monitoring; and (c) evidence-based policies aimed at reducing HI. Conclusion Findings of this Exercise show that ISS researchers identified relevant areas, addressing inequalities in addressing the health. Because of ISS structural peculiarity that includes multidisciplinary expertise, the ISS could provide a significant contribution to HI research challenges and knowledge gaps.
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Pennisi, Leonardo, Anna Lepore, Luigi Santacroce, Roberto Gagliano-Candela, and Ioannis Alexandros Charitos. "Evaluation and Management of Patients with Methomyl Poisoning – A Case Report." Open Access Macedonian Journal of Medical Sciences 8, no. C (May 20, 2020): 76–81. http://dx.doi.org/10.3889/oamjms.2020.4129.
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The Apulian Poison Centre (PC) of Foggia, Italy, annually manages numerous consultations concerning certain or suspected poisonings from pesticides, starting at the same time a careful activity related to the risk assessment phase. The management of the exposure to pesticides and to other chemicals, and the alerting of the “National center for chemicals, cosmetics and consumer protection” at the Istituto Superiore di Sanità (ISS), actively contributes to the improvement of products quality and safety. Thus, leading to a reduction in the number of intoxications - and therefore of the accesses to the emergency services - allows greater protection for workers, bystanders, residents and consumers. The reported case of methomyl poisoning has been of fundamental importance both from the medical point of view and for the management of the intoxicated patient, both for the risk assessment actions, and for cooperation with the competent authorities, generating discussion points on the regulations in force between PCs and National Competent Authority. It follows that the feedback of intoxication in an emergency can lead to improvements in the management and risk mitigation measures in order to reach a greater protection of human, animal, and environmental health. In addition, the regulatory feedback deriving from these reports is an input to the increase product quality improvement (mixtures, labels, packaging, and risk communication) leading to a greater protection of potential exposed subjects. The importance of creating an information and management network that allows the optimization of the flow of information deriving from PCs arises. The actions taken are therefore described, both relating to the management of the emergency, and relating to the subsequent information flow and to the measures for containing the consequent risks.
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Macchia, Iole, Valentina La Sorsa, Irene Ruspantini, Massimo Sanchez, Valentina Tirelli, Maria Carollo, Giorgio Fedele, et al. "Multicentre Harmonisation of a Six-Colour Flow Cytometry Panel for Naïve/Memory T Cell Immunomonitoring." Journal of Immunology Research 2020 (March 28, 2020): 1–15. http://dx.doi.org/10.1155/2020/1938704.
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Background. Personalised medicine in oncology needs standardised immunological assays. Flow cytometry (FCM) methods represent an essential tool for immunomonitoring, and their harmonisation is crucial to obtain comparable data in multicentre clinical trials. The objective of this study was to design a harmonisation workflow able to address the most effective issues contributing to intra- and interoperator variabilities in a multicentre project. Methods. The Italian National Institute of Health (Istituto Superiore di Sanità, ISS) managed a multiparametric flow cytometric panel harmonisation among thirteen operators belonging to five clinical and research centres of Lazio region (Italy). The panel was based on a backbone mixture of dried antibodies (anti-CD3, anti-CD4, anti-CD8, anti-CD45RA, and anti-CCR7) to detect naïve/memory T cells, recognised as potential prognostic/predictive immunological biomarkers in cancer immunotherapies. The coordinating centre distributed frozen peripheral blood mononuclear cells (PBMCs) and fresh whole blood (WB) samples from healthy donors, reagents, and Standard Operating Procedures (SOPs) to participants who performed experiments by their own equipment, in order to mimic a real-life scenario. Operators returned raw and locally analysed data to ISS for central analysis and statistical elaboration. Results. Harmonised and reproducible results were obtained by sharing experimental set-up and procedures along with centralising data analysis, leading to a reduction of cross-centre variability for naïve/memory subset frequencies particularly in the whole blood setting. Conclusion. Our experimental and analytical working process proved to be suitable for the harmonisation of FCM assays in a multicentre setting, where high-quality data are required to evaluate potential immunological markers, which may contribute to select better therapeutic options.
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Ruggeri, Matteo, Chiara Cadeddu, Paolo Roazzi, Donatella Mandolini, Mauro Grigioni, and Marco Marchetti. "Multi–Criteria–Decision–Analysis (MCDA) for the Horizon Scanning of Health Innovations an Application to COVID 19 Emergency." International Journal of Environmental Research and Public Health 17, no. 21 (October 26, 2020): 7823. http://dx.doi.org/10.3390/ijerph17217823.
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Aim: In this article, we aim to present a tool for the early assessment of medical technologies. This evaluation system was designed and implemented by the National Centre for HTA and the National Centre for Innovative Technologies of the Istituto Superiore di Sanita, Italy, in order to respond to an institutional commitment within the “Health Technologies Assessment Team” that was established to face the huge demand for the evaluation of Health Technologies during the pandemic event caused by COVID-19, with a smart and easy-to-use framework. Methods: Horizon scanning was conducted through a brief assessment carried out according to the multicriteria decision analysis methodology. Each HTA domain was attributed a score according to a pros/cons and opportunities/threats system, derived from evidence in the literature. Scores were weighted according to different perspectives. Scores were presented in a Cartesian graph showing the positioning according to the potential value and the perceived risk associated with the technology. Results: Two case studies regarding the early assessment were reported, concerning two specific technologies: an individual protection device and a contact tracking system.
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González-Peñas, Vettorazzi, Lizarraga, Azqueta, and López de Cerain. "Report of the IVth Workshop of the Spanish National Network on Mycotoxins and Toxigenic Fungi and Their Decontamination Processes (MICOFOOD), Held in Pamplona, Spain, 29–31 May 2019." Toxins 11, no. 7 (July 16, 2019): 415. http://dx.doi.org/10.3390/toxins11070415.
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The present publication collects the communications presented in the IV Workshop of the Spanish National Network on Mycotoxins and Toxigenic Fungi and their Decontamination Processes (MICOFOOD), held in the School of Pharmacy and Nutrition of the Universidad de Navarra (Pamplona, Spain) from the 29 to the 31 May 2019. More than 70 professionals from academia, the industry and public services have participated. The scientific program included: five sessions: sponsors (presentation and services), toxigenic fungi, toxicology, analysis and control, and reduction and prevention strategies. In total, 18 oral communications and 24 posters were presented. It is worth mentioning the high participation and quality of the communications from PhD students. The invited conference, entitled: “Mycotoxins within the framework of exposure assessment: past present and future”, was given by Dr. Barbara de Santis (Istituto Superiore di Sanità, Rome, Italy). The meeting ended with the roundtable: “From feed to fork: safe food without mycotoxins”, where representatives of feed and agrofood companies and public administrations discussed about the current situation and problems related with mycotoxins. Different prizes were awarded for the best oral presentation (Effect of Staphylococcus xylosus on the growth of toxigenic moulds in meat substrates, by E. Cebrian et al., University of Extremadura), and the best posters (Combined toxicity of aflatoxins and ochratoxin A: A systematic review by M. Alonso-Jaúregui et al., Universidad de Navarra; and Application of natamycin in products affected by toxigenic fungi by Torrijos et al., Universitat de València). The participants had the opportunity to learn about the history and gastronomy of Pamplona. Situated in the north of Spain, Pamplona is a city of Roman origin featuring a large gothic cathedral complex and a Vauban citadel of the 16th century.
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Donzelli, Alberto, Marco Alessandria, and Luca Orlando. "Comparison of hospitalizations and deaths from COVID-19 2021 versus 2020 in Italy: surprises and implications." F1000Research 10 (September 24, 2021): 964. http://dx.doi.org/10.12688/f1000research.73132.1.
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Data from the Istituto Superiore di Sanità (ISS) emphasized by the media indicate that COVID-19 vaccination reduces related infections, hospitalizations and deaths. However, a comparison showed significantly more hospitalizations and intensive care unit accesses in the corresponding months and days in 2021 versus 2020 and no significant differences in deaths. The combination of non-alternative hypotheses may help explain the discrepancy between the results in the entire population and the vaccination’s success claimed by the ISS in reducing infections, serious cases and deaths: a bias: counting as unvaccinated also "those vaccinated with 1 dose in the two weeks following the inoculation", and as incompletely vaccinated also "those vaccinated with 2 doses within two weeks of the 2nd inoculation".a systematic error: counting as unvaccinated also "vaccinated with 1 dose in the two weeks following the inoculation", and as incompletely vaccinated also "vaccinated with 2 doses within two weeks of the 2nd inoculation". Many reports show an increase in COVID-19 cases in these time-windows, and related data should be separated levels of protective effectiveness in vaccinated people, often considered stable, actually show signs of progressive reduction over time, which could contribute to reducing the overall population resultunvaccinated people show more severe disease than in 2020, supporting also in humans the theory of imperfect vaccines, which offer less resistance to the entry of germs than the resistance later encountered inside the human body. This favors the selection of more resistant and virulent mutants, that can be spread by vaccinated people. This damages first the unvaccinated people, but ultimately the whole community. An open scientific debate is needed to discuss these hypotheses, following the available evidence (as well as to discuss the inconsistent theory of unvaccinated young people as reservoirs of viruses/mutants), to assess the long-term and community impact of different vaccination strategies.
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Marradi, Francesca, Edoardo Staderini, Maria Antonietta Zimbalatti, Andrea Rossi, Cristina Grippaudo, and Patrizia Gallenzi. "How to Obtain an Orthodontic Virtual Patient through Superimposition of Three-Dimensional Data: A Systematic Review." Applied Sciences 10, no. 15 (August 3, 2020): 5354. http://dx.doi.org/10.3390/app10155354.
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Background: This systematic review summarizes the current knowledge on the superimposition of three-dimensional (3D) diagnostic records to realize an orthodontic virtual patient. The aim of this study is to analyze the accuracy of the state-of-the-art digital workflow. Methods: The research was carried out by an electronic and manual query effectuated from ISS (Istituto Superiore di Sanità in Rome) on three different databases (MEDLINE, Cochrane Library and ISI WEB OF SCIENCE) up to 31st January 2020. The search focused on studies that superimposed at least two different 3D records to build up a 3D virtual patient—information about the devices used to acquire 3D data, the software used to match data and the superimposition method applied have been summarized. Results: 1374 titles were retrieved from the electronic search. After title-abstract screening, 65 studies were selected. After full-text analysis, 21 studies were included in the review. Different 3D datasets were used: facial skeleton (FS), extraoral soft tissues (ST) and dentition (DENT). The information provided by the 3D data was superimposed in four different combinations: FS + DENT (13 papers), FS + ST (5 papers), ST + DENT (2 papers) and all the types (FS + ST + DENT) (1 paper). Conclusions: The surface-based method was most frequently used for 3D objects superimposition (11 papers), followed by the point-based method (6 papers), with or without fiducial markers, and the voxel-based method (1 paper). Most of the papers analyzed the accuracy of the superimposition procedure (15 papers), while the remaining were proof-of-principles (10 papers) or compared different methods (3 papers). Further studies should focus on the definition of a gold standard. The patient is going to have a huge advantage from complete digital planning when more information about the spatial relationship of anatomical structures are needed: ectopic, impacted and supernumerary teeth, root resorption and angulations, cleft lip and palate (CL/P), alveolar boundary conditions, periodontally compromised patients, temporary anchorage devices (TADs), maxillary transverse deficiency, airway analyses, obstructive sleep apnea (OSAS), TMJ disorders and orthognathic and cranio-facial surgery.
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Arnaldi, Ugo. "Hadrontherapy in the World and the Programmes of the Tera Foundation." Tumori Journal 84, no. 2 (March 1998): 188–99. http://dx.doi.org/10.1177/030089169808400216.
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Hadrontherapy was born in 1938, when neutron beams were used in cancer therapy, but it has become an accepted therapeutical modality only in the last five years. Fast neutrons are still in use, even if their limitations are now apparent. Charged hadron beams are more favorable, since the largest specific energy deposition occurs at the end of their range in matter. The most used hadrons are at present protons and carbon ions. Both allow a dose deposition which conforms to the tumour target. Radiobiological experiments and the results of the first clinical trials indicate that carbon ions have, on top of this macroscopic property, a different way of interacting with cells at the microscopic level. There are thus solid hopes to use carbon beams of about 4500 MeV to control tumours which are radioresistant both to X-rays and protons. After discussing these macroscopic and microscopic properties of hadrontherapy, the hospital-based facilities, running or under construction, are reviewed. The conclusion is that, while in USA and Japan twelve of these centres will be running around the year 2001, in Europe very little is foreseen to use hadrontherapy to treat deep-seated tumours. The most advanced programme is the Italian one, which is described in the last Sections of the report. The main activities concern the construction, near Milano, of a centre for protons and carbon ions called CNAO (National Centre for Oncological Hadrontherapy) and the development of new type of proton accelerators. The Istituto Superiore di Sanità in Rome obtained the initial financing for constructing, in collaboration with ENEA, a 3 GHz linac, which eventually will accelerate protons to 200 MeV, so as to allow deep protontherapy. These, and other hadrontherapy centres in Italy and Europe, will be connected with oncology centres, hospitals and clinics by a multimedial network called RITA, so that before referral each patient's case can be discussed directly by doctors, even located far away, with the experts sitting in the hadrontherapy centres.
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Gabriele, Pietro, Giuseppe Malinverni, Cristina Bona, Manuela Manfredi, Elena Delmastro, Marco Gatti, Giovanni Penduzzu, Barbara Baiotto, and Michele Stasi. "Are Quality Indicators for Radiotherapy Useful in the Evaluation of Service Efficacy in a New Based Radiotherapy Institution?" Tumori Journal 92, no. 6 (November 2006): 496–502. http://dx.doi.org/10.1177/030089160609200606.
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Aims and background A number of documents assess the need for quality assurance in radiotherapy, which must be constantly monitored and possibly improved. In this regard, a system that confirms the quality of a department has been suggested and quality indicators have been used to improve the quality of the service. The National Health Service ( Istituto Superiore di Sanità) approved a National Research Project to increase the quality of radiotherapy. The aim of the present study was to analyze the practical feasibility and efficacy of the quality indicators elaborated by the National Health Service study group in a radiotherapy unit. Patients and methods The voluntary accredited program was carried out by the Radiotherapy Department of IRCC in Candiolo from June to August 2002. We analyzed 8 of the 13 indicators according to the National Health Service Project. For this purpose, 133 consecutive patients treated in our Unit were analyzed, and the results are reported according to the appropriate indicator (number of staff related to patients treated, waiting list, case history accuracy, multidisciplinary approach, number of treatment plans performed by CT, number of fields per fraction, number of portal imaging performed per overall treatment, and patient satisfaction). Results The number of professional staff related to the number of patients treated was easy to calculate and it could be the basis for further evaluation. The overall waiting time was 55.4 days, and it changed for different radiotherapy goals. We obtained 80% conformity in case-history accuracy. The number of multidisciplinary consultations performed ranged between 50% and 100%. The number of CT plans was about 1.6 ± 0.9 plans per patient. The mean number of fields performed per day and per patient is 3.5 ± 1.7 and was in agreement with the fact that more than 50% of treatments in our Center were performed with conformal radiotherapy. An average of 16.7 ±10.0 portal imaging per case was performed. The percentage of patient satisfaction with the staff obtained a very high compliance. Conclusions The self evaluation promoted by the National Health Service Project allows the monitoring of the activities of the service in order to asses critical factors and it can be the starting point to improve the quality of the service and to compare national and international quality assurance results.
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Comba, Valentina. "Convegno su Biblioteche biomediche e centri di documentazione nella biomedicina: realtá e prospettive, Istituto Superiore de Sanitá, Roma, 12–14 dicembre 1984 (Vilma Alberani and Gabriella Poppi, eds.)." Education for Information 6, no. 1 (January 1, 1988): 96–97. http://dx.doi.org/10.3233/efi-1988-6115.
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Amoretti, Guido. "COVID-19 and Third Age: psychological relapses of “new behaviours”." Geopolitical, Social Security and Freedom Journal 3, no. 2 (December 1, 2020): 137–43. http://dx.doi.org/10.2478/gssfj-2020-0017.
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Abstract The pandemic has forced many countries to introduce restrictions on individual freedom and to support the adoption of hygienically responsible behaviour in order to contain the spread of the infection. The elderly, one of the most fragile sections of the population, have paid and are paying the highest price in terms of contagion and deaths. In Italy, for example, the average age of patients who have died and are positive for SARS-CoV- 2 is 80 years (median 82, range 0–109, InterQuartile Range - IQR 74–88). The median age of SARSCoV- 2 positive deceased patients is over 30 years higher than that of infected patients (median age: deceased patients 82 years - infected patients 48 years) [data from Istituto Superiore di Sanita updated 18/11/2020]. It is clear that preventive measures are essential to preserve the elderly from the risk of contracting COVID- 19. The psychological impact on the elderly and their relatives of the introduction of “new behaviours” and health safety rules that greatly limit social relationships will be discussed. The medium and long term effects of the various forms of isolation that affect both those living in the family and those who are guests of dedicated facilities concern both emotional and cognitive aspects. The risk is that at the end of the pandemic emergency a large number of elderly people will face increasing levels of non-self-sufficiency and the need for medical and health interventions, which were not necessary in the pre-pandemic phase.
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Balić, Davor, and Mario Škrivanko. "Najvažnije parazitarne zoonoze i njihovo javno-zdravstveno značenje u zemljama Europe." Veterinarska stanica 51, no. 5 (July 1, 2020): 559–69. http://dx.doi.org/10.46419/vs.51.5.4.
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Godišnje radionice Europskog referentnog laboratorija za parazite (EURLP) smještenog u Višem institutu za zdravlje (Istituto Superiore di Sanita) u Rimu, prilika su za upoznavanje s aktualnim stanjem najvažnijih parazitarnih zoonoza u Europi. Tijekom dvodnevne radionice predstavnici nacionalnih referentnih laboratorija (NRL) usmeno ili posterima izvještavali su o epidemiološkim i epizootiološkim osobitostima parazitarnih zoonoza u njihovim zemljama tijekom protekle godine. Prezentirani podatci uglavnom se odnose na: godišnje preglede registriranih slučajeva oboljelih ljudi, izvore invadiranja, načine širenja i prenošenja invazija, ispitivanja kojima se provjerava prisutnost, otpornost i preživljavanje razvojnih stadija parazita u okolišu kao i na opise neuobičajenih pojava rijetkih invazivnih zoonoza zabilježenih u europskim zemljama. Epizootiološki podatci odnose se na istraživanja, tj. nadzor nad prisutnošću pojedinih vrsta parazita i/ili njihovih razvojnih stadija u domaćim i divljim životinjama te njihovom potencijalnom značenju za zdravlje ljudi. Sumirane podatke i trendove koji se uoče obradom podataka na razini cijele EU prezentiraju predstavnici Europske agencije za sigurnost hrane (EFSA) i Opće uprave za zdravlje i zaštitu potrošača EU (DG SANCO). Osim predstavnika zemalja članica EU na radionicama su prisutni i predstavnici nečlanica EU, poput Islanda, Norveške, Švicarske, Sjeverne Makedonije i Srbije, koji su često uključeni u zajedničke projekte s članicama zemalja EU i/ili žele biti informirani o aktualnostima iz područja parazitarnih zoonoza na području EU. Posebna pozornost pridaje se predavanjima pozvanih parazitologa iz Europe i svijeta koji prezentiraju rezultate i otkrića dugogodišnjeg rada svojih timova o pojedinim parazitozama i njihovom značenju za javno zdravstvo. Cilj je ovoga rada bio informirati o ehinokokozi i trihinelozi kao najvažnijim parazitozama za javno zdravstvo EU te izvijestiti o značenju i osobitostima opistorhioze koja je opširnije prezentirana na godišnjoj radionici održanoj 2018. godine. Izvijestli smo o neočekivano velikom broju oboljelih ljudi od trihineloze u Hrvatskoj koji je registriran 2017. godine u nekoliko epidemija i sporadičnih slučajeva. Najveća epidemija dogodila se nakon konzumiranja mesnih proizvoda napravljenih od mesa divlje svinje što je i prva službena potvrda invadiranja mesom druge vrste, osim domaće svinje, na području Hrvatske. Zbog karakteristične epidemiološke situacije trihineloza u Hrvatskoj i dalje ostaje parazitoza od najvišeg javno-zdravstvenog značenja.
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Trecate, Giovanna, Daniele Vergnaghi, Siranuosh Manoukian, Silvana Bergonzi, Gianfranco Scaperrotta, Monica Marchesini, Claudio Ferranti, et al. "MRI in the Early Detection of Breast Cancer in Women with High Genetic Risk." Tumori Journal 92, no. 6 (November 2006): 517–23. http://dx.doi.org/10.1177/030089160609200609.
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Aims and background Women with BRCA1 or BRCA2 germline mutations have an elevated risk of developing breast and/or ovarian cancer. Because of the early onset of the disease, screening of this group of women should start at an earlier age than in the general population. The association of breast magnetic resonance imaging (BMRI) and ultrasonography (US) with mammography (MX) and clinical breast examination (CBE) in the regular surveillance of these individuals has been proposed and seems to improve the early detection of breast cancer. Methods Within a multicenter study started by the Istituto Superiore di Sanita (Rome), at the Istituto Nazionale Tumori of Milan (INT) we enrolled 116 women at high genetic risk for breast cancer; they were either BRCA1 or BRCA2 mutation carriers or had a strong family history of breast cancer. They underwent CBE, MX, US and BMRI once a year. Results Between June 2000 and April 2005, at INT 12 cancers were detected among the 116 screened individuals (10%). In this subgroup, 1 patient refused BMRI and in 2 cases US was not performed. With BMRI we found 11 cancers and 6 of them were detectable only by this technique. In these 6 cases, the size of the disease was less than 1 cm and MX was false negative due to irregularly nodular parenchyma in 4 cases and scar tissue or prosthesis in the other 2. US was not performed in 2 cases and was false negative in 4 cases. Three false positive results were found with BMRI: 1 case was considered suspect but related to hormonal influences; 1 case with the same pattern was sent for second-look US, which gave a negative result and BMRI review after 6 months showed normalization of the parenchyma; in the third case histology revealed the presence of adenosis. No false positive results were registered for MX. Conclusions The aim of secondary prevention is the detection of cancer at its earliest stage. BMRI screening in women with BRCA1 or BRCA2 mutations or at high familiar risk appears to be highly sensitive and may detect mammographically occult disease. The accuracy of MR imaging is higher than that of conventional imaging but the technique is flawed by a lower specificity. In order to avoid unnecessary biopsies we believe that the combination of BMRI and conventional imaging can be very useful in screening women with a high genetic risk of breast cancer, especially with second-look evaluation by means of US when BMRI yields the only positive diagnostic result. Second-look US has been demonstrated to be of critical importance both in recognizing false positive BMRI results and in guiding biopsies, when necessary.
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Lazzari, G., I. Lagutina, G. Crotti, P. Turini, S. Colleoni, R. Duchi, and C. Galli. "173 EFFECT OF CULTURE SYSTEM FOR IVM-IVF PIG EMBRYOS ON THE ICMS ABILITY TO PRODUCE OUTGROWTHS FOR EMBRYONIC STEM CELL DERIVATION." Reproduction, Fertility and Development 17, no. 2 (2005): 237. http://dx.doi.org/10.1071/rdv17n2ab173.
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Attempts to derive true embryonic stem cells in large farm animals rely on the supply of good quality embryos. In these species, including the pig, pre-implantation-stage embryos can be produced by in vitro techniques from slaughterhouse ovaries. The objective of this study was to evaluate the ability of the inner cell masses (ICMs) of pig embryos, produced in vitro by different methods, to provide viable initial outgrowths of ICM cells that could be subsequently subcultured and expanded. Porcine oocytes were recovered from slaughtered donors and matured in vitro for 40–44 h in DMEM-F12 supplemented with 10% FCS, 0.05 IU LH and FSH (Menogon, Ferring, Milan, Italy), 0.3 mM cystine, 0.5 mM cysteamine, 50 ng/mL long-EGF, 100 ng/mL long-IGF1, 5 ng/mL bFGF (Sigma-Aldrich, Milan, Italy) in 5% CO2 at 38.5°C. Boar frozen-thawed semen was separated on a percoll gradient and diluted in TALP medium with PHE (penicillamine, hypotaurine, epinefrine) to a concentration ranging from 0.05 to 0.1 million sperm per mL. Oocytes were partially decumulated, co-incubated with sperm for 24 h, and finally denuded and cultured in microdrops of mSOFaa or NCSU. After cleavage, approximately half of the cleaved embryos were surgically transferred into the sheep oviduct for 4 days of in vivo culture and the remaining embryos were left in vitro in the two media. On Day +6 in vivo-cultured embryos were recovered from the sheep oviduct. Blastocyst formation and quality were comparatively evaluated in the three culture groups. Quality specifically referred to the morphology/size of the ICM according to the following criteria: ICM A (large/prominent), ICM B (flat), and ICM C (non-visible). All embryos with a visible inner cell mass were subjected to microdissection with needles to recover the ICMs that were then plated on feeder-layers of mitomycin-treated STO fibroblasts. Attachment and outgrowth was evaluated 48–72 h post-plating. Results are presented in Table 1. Our data indicate that in vivo culture of pig embryos in the sheep oviduct greatly enhance both blastocyst development and ICM quality. As a consequence the efficiency of outgrowth formation, following plating for ES cell derivation, was significantly higher with ICMs derived from IVM-IVF pig embryos cultured in vivo as compared to their in vitro-cultured counterparts. Within the two culture media tested for in vitro culture, SOF and NCSU, the rate of blastocyst formation was similar but the quality of SOF-cultured embryos is higher. In conclusion, embryo/ICM quality represents a fundamental requirement for the derivation of ES cell lines, and in vivo culture in the sheep oviduct provides the most efficient source of high quality IVM-IVF pig embryos. Table 1. Blastocyst development and ICM quality of in vitro-produced pig embryos This work was supported by the Istituto Superiore di Sanità, Programma Nazionale Cellule Staminali, Rome, Italy, grant No. CS 11.
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Cutler, Horace G. "Mycotoxins and Phycotoxins: Developments in Chemistry, Toxicology and Food Safety Edited by Marina Miraglia (Istituto Superiore di Sanita−Food Laboratory, Rome, Italy), Hans P. van Egmond (National Institute of Public Health and the Environment, Bilthoven, The Netherlands), Carlo Brera (Istituto Superiore di Sanita−Food Laboratory, Rome, Italy), and John Gilbert (Ministry of Agriculture, Fisheries and Food, Norwich, U.K.). Alaken, Inc., Fort Collins, CO. 1998. xii + 610 pp. 15 × 22.5 cm. $180.00. ISBN 1-880293-09-9." Journal of Natural Products 62, no. 3 (March 1999): 542. http://dx.doi.org/10.1021/np980253u.
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Mezzetti Pantanelli, Renata. "Movimento espressivo e bioenergetica: un percorso di vita." GROUNDING, no. 2 (January 2013): 85–93. http://dx.doi.org/10.3280/gro2012-002007.
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L'autrice č stata insegnante di Ginnastica Ritmica all'ISEF-IUSM (Istituto Superiore di Educazione Fisica, poi Istituto Universitario di Scienze Motorie) di Roma. Ha frequentato il 2° Training di formazione in analisi bioenergetica della Siab con lo scopo di integrare i fondamenti dell'analisi bioenergetica con la ginnastica ritmica. Il contributo illustra il frutto dell'integrazione nei suoi elementi principali, fornendo anche una revisione del concetto stesso di sport. L'autrice ha, inoltre, sviluppato l'insegnamento della ginnastica ritmica per gli allievi maschi in gruppi misti.
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. "Dieci anni di AIRP La ricerca e l'impegno." Giornale di Clinica Nefrologica e Dialisi 27, no. 4 (December 9, 2015): 271–80. http://dx.doi.org/10.33393/gcnd.2015.846.
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Il decennale AIRP è stato celebrato con il Meeting internazionale del 19 Settembre scorso a Roma all'Istituto Superiore di Sanità. Importanti relatori del mondo della nefrologia hanno dato vita a un incontro ricco di approfondimenti su ADPKD e ARPKD, con particolare attenzione alla diagnosi precoce e alla gestione terapeutica di queste patologie. Fondamentale, come sempre, la partecipazione dei pazienti, con le loro domande, le loro curiosità e i loro racconti di esperienze personali. Pubblichiamo, in questo numero, gli abstract delle relazioni presentate al Meeting.
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Cubadda, Francesco. "Preface." Pure and Applied Chemistry 82, no. 2 (January 1, 2010): iv. http://dx.doi.org/10.1351/pac20108202iv.
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Diet is the main source of trace elements, and exposure to dietary trace elements has a direct impact on the health of hundreds of millions worldwide. Insufficient intake of essential trace elements is a global issue. Deficiencies of iron, zinc, iodine, and selenium result in millions of people being affected by various diseases, with very serious consequences in those countries where malnutrition is widespread. On the other hand, the impact of toxic element species such as inorganic arsenic and methylmercury on entire populations has come to the fore again as a priority for both the scientific community and health authorities. The presence of trace elements in feeds, either as contaminants or as nutritional or zootechnical additives, and their transfer across the food chain to humans also raises questions within the scientific community and regulators.Different facets of trace elements, from essentiality to toxicity, were addressed throughout the 3rd International IUPAC Symposium on Trace Elements in Food (TEF-3). The meeting was organized by the Istituto Superiore di Sanità and held on 1-3 April 2009 in Rome, Italy. The objective was to gather experts with different backgrounds to discuss all aspects of trace elements in food in relation to human health, with special emphasis on biological effects of elements. The main topics included essentiality, toxicity, bioaccessibility, bioavailability, speciation, sources and transfer in the food chain, effects of processing, food and feed fortification, supplementation, international legislation and standards, analytical developments, analytical quality assurance and reference materials. In accordance with practice in previous events of this series (Warsaw, 2000, and Brussels, 2004), TEF-3 provided a forum for the exchange of new ideas and experiences in trace element research, and a basis for influencing policy, advisory practice, and risk-management tools to protect public health.Over 200 participants, representing some 40 countries, joined the event. In addition to the 15 invited lectures, delegates from Europe, Asia, Africa, North and South America enriched this edition with 20 oral and about 130 poster contributions. TEF-3 actually resulted in a lively interdisciplinary symposium on current and emerging research and development efforts.Special emphasis was placed on the following topics:- analytical techniques for element speciation studies in food and food supplements- reliability and quality control of analytical data on trace elements in foodstuffs- detection, characterization, and potential health risks of inorganic nanoparticles- arsenic speciation and toxicology- gender differences in susceptibility to toxic trace elements in food- exposure assessment of toxic element species- assessment of risks and benefits of the organic forms of trace elements as feed additives- metabolism of metal(loid)s by intestinal microorganisms- absorption and metabolism of iron, zinc, and other essential elements- use of stable isotopes to study trace mineral metabolism- selenium and iodine speciation and biological effectsAdvancements in the above-mentioned areas were discussed, and special attention was paid to the means in order to prevent adverse health effects on those individuals and populations most vulnerable to trace-element inadequacies, excesses, or imbalances.The following collection of papers based upon authoritative lectures presented at TEF-3 addresses many of the topics discussed during the symposium. Overall, it provides an excellent overview of the state of the art in the area of trace elements in food and sheds light on future challenges and subjects of research.Francesco CubaddaConference Chair
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Ricciardi, Walter. "Health Systems, Quality of Health Care, and Translational Cancer Research: The Role of the Istituto Superiore Sanità -Rome." Tumori Journal 101, no. 1_suppl (December 2015): S67—S68. http://dx.doi.org/10.5301/tj.5000470.
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Cox, Maria Christina, Imerio Capone, Carmen Rozera, Laura Santodonato, Caterina Lapenta, Antonio Pavan, Mauro Mattei, et al. "Personalized Immunotherapy in Follicular Lymphoma By Intranodal IFN-Dendritic-Cell Combined to Anti-CD20 Antibody." Blood 128, no. 22 (December 2, 2016): 2976. http://dx.doi.org/10.1182/blood.v128.22.2976.2976.
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Abstract INTRODUCTION Follicular lymphoma (FL) is considered a chronic, immune responsive and still incurable tumour. Recently two papers have shown the efficacy of active immunotherapy by repeated administration of autologous dendritic cells (DC) in Follicular Lymphoma (FL). Notably, in both studies a third of patients achieved long lasting remission. A novel DC population (IFN-DC), differentiated from human monocytes in the presence of GM-CSF and IFN-alpha has been developed in the laboratory of the Istituto Superiore di Sanità (ISS). IFN-DC have been demonstrated highly efficient in internalizing tumour-cell antigens, recovering "in vitro" T-cell responses from FL patients, as well as in mediating NK cell activation and enhanced cytotoxic effector function toward autologous FL cells. We have recently started a phase I study (approved by EC in 2014, EudraCT: 2013-003158-25) of intranodal immunotherapy based on sequential injection of low-dose anti-CD20 antibody (Ab) and IFN-D, in patients with advanced FL. Here we report early results of the ongoing trial. STUDY DESIGN IFN-DC Trial (EudraCT: 2013-003158-25) is a phase I trial aiming at evaluating safety and tolerability as well as immune and clinical responses of a IFN-DC based therapy in combination with rituximab for the treatment of patients with advanced FL. · The Primary endpoints are: I) Evaluation of safety and tolerability of treatment II) Evaluation of tumor-specific immune responses. by determining: i) Tumor-specific immune response in peripheral blood; ii) Intratumoral infiltration of immune cells; iii) DTH test. · The secondary endpoint is clinical response. The study population consists of patients with relapsed/refractory FL, aged 18-75 years, not needing immediate retreatment basing on the GELF Criteria. The · Treatment: the regimen foresees eight injection cycles, each consisting of the combined administration of rituximab and IFN-DC. The first four administered every two-weeks and the remaining four administered monthly. Rituximab (5-10mg) and low or high doses of IFN-DC (20±5 x106 or 40±5x106cells respectively), are administered by intranodal direct injection (IDI). RESULTS Five patients have been enrolled so far. The treatment proved to be safe, feasible and well tolerated. Three patients have completed treatment and two experienced complete remission with disappearance of both proximal and distal lesions, as confirmed by PET scan. Notably in both patients the distal lymph nodes, which had not been directly treated by intranodal injections, reduced to normal size earlier than those treated by IDI (abscopal effect). One of these two is still in durable complete clinical and molecular remission after 17 months while the latter patient, who had progressed after completing eight cycles of treatment, experienced a complete clinical remission after a second course of immunotherapy ( Fig.1). Two out of three patients performed the DHT test and, despite one of the two achieved remission, they both resulted non-responsive. The characterization of IFN-DC and lymphoma nodes in FL patients have shown high expression of PD-1 and PD-L1 in FL microenvironment and on IFN-DC respectively. Immunomonitoring is currently underway. However, quantification of NF-kB (p65) nuclear translocation by multispectral image flow cytometry, as a marker of NK cell activation, showed the persistence of higher percentages of activated NK cells in the two responding patients (Fig.2). CONCLUSION Currently no definitive data prove the benefit of IDI treatment, however the trial is ongoing and other patients are under screening. Notably both the responding patients showed the abscopal effect. The possible set-up of an effective and comparatively economic treatment, that exploits patients' immune system against this chronic and immune responsive tumour, is worth of exploring. Furthermore it can be envisaged that the combination of immune checkpoint inhibitor antibodies to DC-based therapies, might improve clinical activity of DC-based strategies. Disclosures No relevant conflicts of interest to declare.
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Tekavčić, Pavao. "Un nuovo periodico di studi italiani «Nuova Corvina», Rivista di Italianistica dell'Istituto Italiano di Cultura per l'Ungheria, num. 1, Budapest 1993, 144 pagine." Linguistica 35, no. 2 (December 1, 1995): 324–25. http://dx.doi.org/10.4312/linguistica.35.2.324-325.
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Siamo lieti di poter presentare ai lettori di «Linguistica» la nuova rivista dilin gua, letteratura e cultura italiana, «Nuova Corvina», apparsa nella vicina Ungheria.Inapertura del primo numero si legge che ilperiodico «intende promuovere gli studidiitalianistica,favorendol'interscambioelacircolazionedelpensierotragliitalianistiungheresi ed i colleghi operanti negli altri paesi» [p. 2]. Prevista per adesso come anuale,con la speranza che possa diventare per lo meno semestrale [p.7],«Nuova Corvina» èl' organo del citato Ente culturale, ed il comitato di redazione è costituito da quattro eminenti studiosi ungheresi: Lajos Antal (Istituto Superiore di Magistero di Szombathely),Gyula Herczeg (Università di Pécs), József Pál(Università di Szeged) e Győző Szabó (Università di Budapest).
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Donvito, Valentina, and Maria R. Giolito. "Contraccezione ormonale e rischio tromboembolico: dalle raccomandazioni della Regione Piemonte alla conferenza di consenso dell’Istituto Superiore di Sanità." Italian Journal of Medicine 4, no. 3 (September 2010): 150–53. http://dx.doi.org/10.1016/j.itjm.2010.05.001.
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Stokłosa, Marek. "Legalne przebywanie zakonnika poza wspólnotą zakonną." Prawo Kanoniczne 53, no. 1-2 (January 9, 2010): 105–28. http://dx.doi.org/10.21697/pk.2010.53.1-2.06.
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Uno tra i doveri della vita religiosa si riferisce all’obbligo di residenza nella propria casa religiosa nella quale i membri della comunità osservano la vita comune dell’istituto. L’oggetto proprio della norma canonica del can. 665 § 1 è la permanenza abituale del religioso nella propria casa religiosa. Tuttavia, per esigenze dello stesso istituto, come pure per motivi personali, il religioso può assentarsi dalla propria casa religiosa, però con l’autorizzazione del competente superiore. Questo allontanamento potrebbe essere trattato come una semplice uscita quotidiana, o può diventare una vera assenza di breve termine, o un’assenza prolungata. Tutte queste uscite quotidiane per ragioni tanto ministeriali, quanto personali, devono essere regolate dai superiori locali, non dai superiori provinciali, per mezzo di permessi concessi secondo le usanze della rispettiva comunità, che possono essere ad actum o abituali, espressi o taciti, o anche impliciti e presunti. Il diritto comune, dopo aver stabilito l’obbligo di risiedere nella propria casa di assegnazione, determina che spetta al superiore maggiore, con il consenso del suo consiglio, concedere, per una giusta causa, a un religioso, di vivere fuori delle comunità dell’istituto (“extra domum instituti”) per un tempo che non superi la durata di un anno, a meno che non si tratti di malattia del religioso, tempo dei suoi studi, o di apostolato svolto in nome dell’istituto. È da osservare il fatto che la suddetta norma del diritto comune fa tacitamente una distinzione tra assenza prolungata dalla propria casa per dimorare in un’altra casa dell’istituto, dall’assenza prolungata dalla casa dell’istituto in genere. Considerando che il primo tipo di assenza non viene contemplato dal diritto comune, il diritto proprio potrà stabilire norme applicative più particolareggiate. Il superiore maggiore, con il consenso del proprio consiglio, può concedere, a norma del can. 665 § 1, la licenza di assenza dalla casa dell’istituto per un periodo superiore a un anno per motivo di malattia, di studio o di apostolato svolto a nome dell’istituto.
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YOKOTE, Yoshihiro. "THE FOUNDATION OF ISTITUTO TECNICO SUPERIORE DI MILANO AND C. BOITO'S PRINCIPLE OF THE ARCHITECTURAL EDUCATION." Journal of Architecture and Planning (Transactions of AIJ) 66, no. 541 (2001): 259–64. http://dx.doi.org/10.3130/aija.66.259_2.
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Gedda, Luigi. "Come Nacque l'Istituto Mendel." Acta geneticae medicae et gemellologiae: twin research 46, no. 3 (July 1997): 129–33. http://dx.doi.org/10.1017/s0001566000000532.
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Nelle aule delle Università di Pavia, Milano e Torino che ho frequentato a motivo dei continui spostamenti della mia famiglia ho trascorso e concluso il mio “curriculum” conseguendo la laurea in Medicina nel 1927 e poi la Libera Docenza in Patologia Speciale Medica nel 1931.Nel mio trasferimento a Roma ebbi l'intuizione della Genetica studiando i caratteri somatici di una coppia di gemelli identici osservandone la concordanza contemporanea caratteristica ed in particolare la concordanza anche quantitativa di polimorfismi ematici, in particolare delle frazioni del glutatione ematico. Le concordanze nei gemelli monozigotici mi aprirono la strada alla genetica. Questo avvenne nel 1933.Nel 1938, ebbi occasione di conoscere Madre Luisa Tincani che avendo fondato un Istituto Superiore parificato per religiose si trovava in difficoltà perché avrebbe dovuto rispettare il decreto del Governo fascista sull'insegnamento delle leggi razziali. Ritenni che avrei potuto aggirare l'ostacolo insegnando a quelle religiose le leggi di Mendel che sono il punto di partenza per lo studio di ogni carattere ereditario normale o patologico.Quel mio corso andò benissimo in quanto insegnai non solo le leggi di Mendel ma conobbi la figura di un grande personaggio sacerdote, confessore dei prigionieri nel carcere dello Spielberg e Abate che, nel giardino del convento conduceva le sue esperienze che ebbero come oggetto principale il pisum sativum. cioè il pisello.Mentre andavo approfondendo la mia conoscenza dell'Abate agostiniano Gregorio Mendel mi sorprendevo che a Roma non ci fosse nessuna traccia di lui. Di qui nacque l'idea di creare in Roma un Istituto dedicato alla Genetica che portasse il suo nome anche perché questa scienza aveva, nel frattempo, fatto dei passi giganteschi, per cui progettai di costruire nelle adiacenze della Università “La Sapienza” un Istituto che portasse il nome di Mendel (Fig. 1).
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Introna, Martino, Elisa Gotti, Michela Bonzi, Josee Golay, Alessandra Algarotti, Caterina Micò, Anna Grassi, et al. "A Multicenter Phase II Study of Sequential Administration of Unmanipulated DLI and Donor Derived Cytokine Induced Killer (CIK) Cells in HSCT Patients, Relapsed of Disease." Blood 126, no. 23 (December 3, 2015): 3160. http://dx.doi.org/10.1182/blood.v126.23.3160.3160.
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Abstract Introduction Cytokine Induced Killer (CIK) cells are memory T lymphocytes which have acquired CD56 expression and Natural Killer (NK) like unrestricted cytotoxicity, following in vitro activation by anti CD3 OKT3 and IFNg and subsequent expansion with IL-2. CIK cells have demonstrated in vitro and in vivo anti tumor activity, direct intratumor homing following iv. administration and, more importantly, a very reduced Graft Versus Host (GVH) activity, in several experimental allogeneic models. Indeed we and others have demonstrated very limited GVH activity in preliminary phase I studies, with donor derived (matched) CIK cells in patients with different hematological neoplasms, previously treated by allogeneic Hematopoietic Stem Cells (HSC) transplantations and subsequently relapsed of diseases 1. Methods To better delineate the toxicity profile, as well as the potential anti tumor efficacy, of donor derived CIK cells, we prospectively studied 48 patients relapsed after allogeneic stem cell transplantation performed using either a matched related (N=28) or unrelated donor (n= 20, including 1 haplo). This phase II multicenter study was authorized by Istituto Superiore di Sanità, as for Advanced Therapeutic Medicinal Product (ATMP) regulations, approved by the Agenzia Italiana del Farmaco and (AIFA). The trial was registered as (EUDRACT n 2008-003185-26, ClinicalTrial.gov: NCT01186809) Results In this interim analysis, forty-eight patients (including childrens and adults) have been so far enrolled into this study protocol. The median age was 48 (range 6-67) and a diagnosis of ALL (n=9, 20%), AML (n=29, 60%), MM (n=5, 8%), HD (n=3, 6%), MPN (n=2, 4%), NHL (n=1, 2%). Reasons for being enrolled into study was a hematologic relapse in 36 (75%) or a molecular relapse in 12 (25%). The therapeutic strategy consisted of two infusions of unmanipulated DLI (each of 1 x 106/kg cells) at 3 weeks interval, followed by three infusions of donor derived CIK cells given at 3 weeks interval. The first 12 patients were treated with growing numbers of CIK cells, in groups of three patients per dose level. Since DLT was never observed (acute GVHD of grade III or more) the highest dose planned (5 x 106/kg, 5 x 106/kg and 10 x 106/kg) was then administered to subsequent consecutive 36 patients. 4 patients died for disease progression and 1 patient developed aGVHD (grade I, skin only) during the DLI treatment and could not proceed to the planned subsequent CIK administration. Of the 43 patients who eventually received at least one infusion of CIK cells, 15 patients did not complete the program, 9 for disease progression and death, 3 for insurgence of grade II aGVHD (skin only in 2 cases, skin and gut in 1 case), 1 for hemolytic anemia, 1 for insufficient cell supply and 1 for medical decision. Overall, 28 patients received the complete cell therapy planned (58%). Overall, of the 48 patients enrolled, 5 (10%) suffered from aGVHD (1 grade I, 3 grade II, 1 grade III). During follow up, chronic GVHD was observed in 7 patients (14 %) (3 mild and 4 moderate). As per protocol, clinical response was determined 100 days after the last CIK administration and the study was analyzed on an intent to treat basis. An early death occurred in 13 (27%) patients (4 during the DLI), before the clinical response could be evaluated. A CR was observed in 9 (19 %) and a PR in 7 (14%) for an overall response rate of 16 (33%). No response was observed in 19 (39%). At 2 and 4 years, the event free survival of the 48 patients is 22% and 18%, while the overall survival is of 37% and 34%, respectively. For the small group of patients who achieved a complete response, the disease free survival is of 64% at 2 years and 51% at 4 years. By univariate analysis, survival was significantly associated to the type of relapse (molecular) (p 0.0081) since at 2 and 4 years it was and 24% and 27% vs. 71% and 71 % for patients enrolled for a hematologic or a molecular relapses, respectively. By multivariate analysis, the type of relapse remained the only significant predictor of survival (0.0160 p value). Conclusion This study shows the feasibility of CIK preparation and administration as well as the relatively low toxicity of the program (10% aGVHD grades I-III) in spite of the fact that 20 patients received cells from matched unrelated donors. Finally, the study offers the suggestion that CIK cells may be efficacious to treat post-transplant relapse. 1 Introna M. et al, Haematologica, 2007, 92, 7, 948. Figure 1. Figure 1. Disclosures Introna: roche: Research Funding. Rambaldi:Roche: Honoraria; Novartis: Honoraria; Amgen: Honoraria; Celgene: Research Funding; Pierre Fabre: Honoraria.
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Lussana, Federico, Martino Introna, Josee Golay, Federica Delaini, Chiara Pavoni, Ruth Valgarsddottir, Elisa Gotti, et al. "Final Analysis of a Multicenter Pilot Phase 2 Study of Cytokine Induced Killer (CIK) Cells for Patients with Relapse after Allogeneic Transplantation." Blood 128, no. 22 (December 2, 2016): 1160. http://dx.doi.org/10.1182/blood.v128.22.1160.1160.
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Abstract Introduction: Patients with disease relapse after allogeneic transplantation (alloHSCT) have a poor prognosis. Donor lymphocyte infusion (DLI) is one of the main clinical options to salvage patients in relapse after transplant. Cytokine Induced Killer (CIK) cells are in vitro activated and expanded T lymphocytes which have acquired NK like cytotoxicity as well as CD56 expression. CIK cells have shown Graft versus Leukemia (GvL) activity with little GvHD and therefore may represent an ideal candidate to treat post-transplant relapse. We report the final results of a phase II multicenter pilot study, whose objective was to evaluate the safety and efficacy of sequential administration of donor derived unmanipulated DLI and CIK cells in patients with recurrent hematologic cancers after alloHSCT. Methods Seventy-four patients relapsed after alloHSCT, performed using either a matched related (N=42) or unrelated donor (n= 32), were enrolled in the study. This phase II multicenter study was authorized by Istituto Superiore di Sanità, as for Advanced Therapeutic Medicinal Product (ATMP) regulations, and approved by the Agenzia Italiana del Farmaco (AIFA). The trial was registered as (EUDRACT number 2008-003185-26, ClinicalTrial.gov : NCT01186809). Results Among the 74 patients (including 16 children and 58 adults) enrolled into this study (median age 45, range 1-67), 20 had a diagnosis of ALL (27%), 41 of AML (55%), 4 of MM (5%), 3 of HD (4%), 2 of NHL (3%) and 4 of MPN (5%). All patients relapsed after matched allogeneic transplants (32 unrelated and 42 sibling), of whom 44 (59%) suffered from a hematological, 4 (5%) from a cytogenetic and 26 (35%) from a molecular relapse. The therapeutic strategy consisted of two infusions of unmanipulated DLI (each of 1 x 106/kg cells) at 3 weeks interval, followed by three infusions of donor derived CIK cells given at 3 weeks interval. The first 12 patients were treated with increasing numbers of CIK cells, in groups of three patients per dose level. Since dose limiting toxicity (DLT) was never observed (acute GVHD of grade III or more), the highest dose planned (5 x 106/kg, 5 x 106/kg and 10 x 106/kg) was then administered to all patients. Ten patients died for disease progression, 1 patient developed aGVHD (grade I, skin only) and 1 withdrawn for medical decision before or during the DLI treatment and could not proceed to the planned subsequent CIK administration. Sixty-two patients received at least one infusion of CIK cells, of whom 43 patients (61%) completed the cell therapy program, while 3 patients are still under treatment. The study flow is outlined in Figure 1. As per protocol, clinical response was determined 100 days after the last CIK administration and the study was analyzed on an intent to treat basis. An early death occurred in 24 (32%) patients (4 during the DLI), no response was observed in 18 (24%) patients, a stable disease in 1 patient (1%), a complete remission in 21 (28%) and a partial remission in 6 (8%), for an overall response rate of 36%. In 4 patients clinical response could not be evaluated (3 patients still in treatment and 1 withdrawn from the protocol). Acute GVHD was observed in a total of 11 patients (15%): grade 1 (n=4), 2 (n=2) and 3-4 (n=5). During follow up, chronic GVHD was observed in 8 patients (11 %) (3 mild, 4 moderate and 1 severe). By univariate analysis, progression free survival (PFS) and overall survival (OS) were significantly associated (p<0.0001) with the type of relapse since at 3 years it was 11% and 23% vs. 54% and 77 % for patients enrolled due to a hematologic vs. a molecular/cytogenetic relapses, respectively (Figure 2A-B). By multivariate analysis, the type of relapse remained the only significant predictor of survival (p=0.0019). Conclusion Our study shows that administration of CIK cells is feasible in patients with recurrent hematologic cancer after alloHSCT with a relatively low toxicity in terms of GvHD. Particularly in the setting of the molecularly relapsed patients, long-term survival can be achieved. In future studies, we are planning to test CIK cells in preventing post-transplantation relapse in high risk AML. Finally, CIK cells may represent an innovative platform to transduce chimeric antigen receptors in allogeneic T cells with a reduced risk to induce GvHD. Disclosures Biondi: Cellgene: Other: Advisory Board; BMS: Membership on an entity's Board of Directors or advisory committees; Novartis: Membership on an entity's Board of Directors or advisory committees, Other: Advisory Board.
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STOKŁOSA, MAREK. "Le competenze del superiore provinciale di un istituto religioso riguardo ai beni temporali e della loro amministrazione." Prawo Kanoniczne 59, no. 3 (January 18, 2017): 31. http://dx.doi.org/10.21697/pk.2016.59.3.03.
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