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Journal articles on the topic 'It's Used In Sustained Release'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Vaishali, S. Kadam G. R. Shendarkar. "ROLE OF NATURAL POLYMER IN SUSTAINED AND CONTROLLED RELEASE." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 01 (2017): 7390–400. https://doi.org/10.5281/zenodo.1006885.

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Now a day there has been an important development in different dosage forms for existing and newly designed drugs and natural products, and synthetic as well as semi-synthetic excipients always need to be used for a variety of purposes. Gums and mucilages are widely used as natural materials for conventional and novel dosage forms. With the increasing interest in polymers of natural origin, the pharmaceutical world has compliance to use most of them in their formulations. Moreover, the tremendous orientation of Pharmaceutical world towards these naturally derived polymers has become a subject

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2

Shanker, Oma, Arsh Chanana, Pooja Gupta, et al. "Niosomal Drug Delivery System used in Tuberculosis." Journal of Drug Delivery and Therapeutics 14, no. 3 (2024): 218–26. http://dx.doi.org/10.22270/jddt.v14i3.6475.

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Niosomes are artificially manufactured vesicles made of Cholesterol and Non-ionic surfactant. Their capacity to encapsulate a broad variety of pharmaceuticals and shield them from deterioration has piqued interest in drug delivery. Niosomes have demonstrated a possible use in the administration of anti-tuberculosis medications. Worldwide, tuberculosis is a serious public health concern. Even with advances in science and technology, tuberculosis remains a persistent problem.Niosomes can encapsulate anti-TB drugs, protecting them from enzymatic degradation and allowing for sustained release. Res

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3

Chourey, Nikita, and Khushi Chouksey. "Formulation and Evaluation of Enteric Coated Matrix Tablets of Mesalamine for Inflammatory Bowel Disease." Journal of Drug Delivery and Therapeutics 12, no. 1 (2022): 56–61. http://dx.doi.org/10.22270/jddt.v12i1.5176.

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Mesalamine is a gold standard anti-inflammatory drug used to treat inflammatory bowel illnesses. It's usually used to treat and keep Ulcerative Colitis in remission in mild to moderate cases. Mesalamine is rapidly cleared from circulation after being consumed orally, with an elimination half-life of only one hour. Oral intake of delayed or slow released matrix formulations can acquire therapeutic concentration in the intestines. The goal of this study was to use guar gum as a carrier to develop colon-specific delivery methods for mesalamine. The matrix tablets were made using the direct compre

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*Ramachandra, M. Koli Manojkumar S.Patil Sandhyarani S. Kamble Meghraj A. Patil Shashikant P. Jokar Bharat B. Garande. "DEVELOPMENT AND EVALUATION OF RABEPRAZOLE GASTRORETENTIVE DRUG DELIVERY SYSTEM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 06 (2018): 5047–59. https://doi.org/10.5281/zenodo.1286333.

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The present study was undertaken with an aim to design, develop and evaluate floating tablet of Rabeprazole, which release the drug in a sustained manner over a period of 12 hours. In this resesrch work used hydroxy propyl methyl cellulose(HPMC K15M), gas generating agent sodium bicarbonate and citric acid. The high level of HPMC K15M and citric acid favors preparation of floating tablet Rabeprazole. The tablets were prepared by direct compression techniques and evaluated thickness, hardness, weight variation, friability, floating lag time and In-vitro drug release studies indicated that the f

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5

Pooja Mallya, Gowda D V, Mahendran B, Bhavya M V, and Vikas Jain. "Recent developments in nano micelles as drug delivery system." International Journal of Research in Pharmaceutical Sciences 11, no. 1 (2020): 176–84. http://dx.doi.org/10.26452/ijrps.v11i1.1804.

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Targeting of the drug directly to the cells, tissues, or organs with no impact on healthy cells is a challenge. In the current era, it's been made possible by therapeutic interventions. The novel drug delivery systems such as nano particulates, liposomes, aquasomes, phytosomes, dendrimers, nano sponges, nano micelles are developed. Nano micelles are developed for efficient targeting and are currently in trend as therapeutic carriers of water-insoluble drugs. Micelles are self-assembling Nano-sized colloidal particles with a hydrophobic core and hydrophilic shell. Among the micelle-forming comp

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Vasanth, B.*1 A. Vasanthan2 Senthilkumar K. L.3. "Formulation And Evalution Of Nanoparticles Loaded Topical Drug Delivery System Of An Anti-Fungal Drug." International Journal in Pharmaceutical Sciences 2, no. 5 (2024): 823–38. https://doi.org/10.5281/zenodo.11208130.

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Ketoconazole is a synthetic antifungal agent belonging to the group of triazole. Itis one of the commonly used antifungal agents for the treatment of local and systemic fungal infections. It is a BCS class II drug (low solubility and high permeability). On oral administration, its bioavailability is low due to poor aqueous solubility. The objective of this work is to prepare Ketoconazole nanoparticles and then incorporated into the freshly prepared gel for transdermal delivery, because patients with Skin infection such as athlete's foot, jock itch, ringworm, and certain kinds of dandruff. The

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7

Gupta, Kajal. "Formulation and Evaluation of Metformin Using Fenugreek Seed Mucilage Used as a Natural Polymer." International Journal of Advanced Pharmaceutical Sciences and Research 4, no. 4 (2024): 35–41. http://dx.doi.org/10.54105/ijapsr.f4051.04040624.

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The major goal of this study was to develop and test metformin sustained release tablets employing fenugreek seed mucilage (FSM) as a new binder, as opposed to standard polymers such as xanthan gum and HPMC. The study shows how FSM provides sustained medication release while keeping metformin physicochemical characteristics. The sustained-release matrix tablets were made on a laboratory scale utilizing the wet granulation process. 5 batches were created, each with varying quantities of fenugreek seed mucilage, xanthan gum, and HPMC. To examine the tablet's physical properties and consistency,

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Singh, Neha, Durga Pandey, Nilesh Jain, and Surendra Jain. "Formulation and In Vitro Evaluation of Bilayer Tablets of Lansoprazole and Amoxycillin Trihydrate for the Treatment of Peptic Ulcer." Journal of Drug Delivery and Therapeutics 11, no. 1 (2021): 23–31. http://dx.doi.org/10.22270/jddt.v11i1.4481.

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The present work involves the formulation development, optimization and In-vitro evaluation of bilayer tablet containing Lansoprazole in the immediate release layer and Amoxycillin in the sustained release layer, using sodium starch glycolate as a super disintegrant for the immediate release layer and the hydrophilic matrix HPMC K100M, hydrophobic matrix Ethyl cellulose are used in the sustained release layer. Bilayer tablet showed as initial burst effect to provide dose of immediate release layer Lansoprazole to control the acid secretion level and the sustained release of Amoxycillin for 24

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9

Yani, Tan, Lin Junming, Zhang Zhen, He Rongrong, and Li Sha. "Studies on Sustained Release Tablets of Theacrine with Erodible Matrix Material." Journal of Pharmaceutical and Biomedical Sciences 11, no. 03 (2021): 60–71. https://doi.org/10.5281/zenodo.4818212.

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<strong>Background </strong>Theacrine is a purine alkaloid with sedative, hypnotic and liver protection effects, which was investigated in treatment of insomnia, liver damage and hepatic steatosis. These are generally chronic diseases needing long-term medication. Sustained release preparations have good effect and compliance in prolonged treatment. <strong>Aim</strong> This study aimed to develop theacrine sustained release tablets using wax matrix material with simple preparing process. Methods: The content assay method of theacrine was developed using UV-visible spectrophotometry, and the m

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10

Kumari, Satish, Anchal Puri, Dhruv Dev, DN Prasad, and ,. Monika. "A review on polymers in natural or modified form used in sustained release tablet." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 870–73. http://dx.doi.org/10.22270/jddt.v9i3-s.2843.

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Tablet is a solid dosage form which is used to deliver the drug to the body to make pharmacological action. The oral dosage form should disperse into small particles to deliver active ingredients in the body, the disperse time of the dosage form depends on the ingredients which are used in the tablet. To make the tablet disintegrate slow usually sustained release agents are used. The sustained release tablets helps in maintaining the drug concentration in the body for the higher time. In this review article various polymers of natural origin and their modified forms are studied, which can be u

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11

Prasanth, Yerramsetti *. James Bokam. "Controlled Release Medication Delivery Systems: Using Artificial Neural Networks In Their Creation." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 404–17. https://doi.org/10.5281/zenodo.12672516.

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Systems for delivering drugs with controlled release have many benefits over traditional dose forms. But because controlled release medication delivery systems are so complex, creating them effectively presents significant hurdles. One method that has been used to create and construct controlled release dose forms is the traditional statistic response surface methodology (RSM). It should be noted that the RSM technique has several limitations. In order to create controlled release dosage forms, a different method known as artificial neural networks (ANN) has recently become quite popular. The

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12

Mehta, Mandev, H. S Keerthy, and Rajkumar Prasad Yadav. "Sustained Release Matrix Tablet: An Overview." Asian Journal of Pharmaceutical Research and Development 9, no. 3 (2021): 112–17. http://dx.doi.org/10.22270/ajprd.v9i3.954.

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Sustained Release is also a promising method for reducing medication side effects by preventing the therapeutic concentration of the drug from fluctuating in the body.The basic rationale of a sustained drug delivery system is to optimise a drug's biopharmaceutical, pharmacokinetic, and pharmacodynamic properties in order to maximise utility, minimise side effects, and cure the disease. The drug release rate is regulated by the matrix. HPMC and other release retardants can help with sustained release, so they are used as a key excipient in the formulation.The method entails compressing a mixtur

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13

Pradeep Kumar S, Gowda D V, and Vikas Jain. "Recent Development in Sustained Release Beads." International Journal of Research in Pharmaceutical Sciences 11, no. 1 (2020): 891–98. http://dx.doi.org/10.26452/ijrps.v11i1.1911.

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The sustained release system is formulated to release a drug slowly over a period of time in the body. The sustained release system is having more therapeutic activity of a drug when compared to immediate release. Beads is one of the most commonly used technique in a sustained release dosage form. These are the spherical particle with size ranging from 50nm to 2mm, which contains core substances. The molecular size of the drug particle must be lesser than 1000 Dalton to formulate as SRDF. This article also contains the method of preparation by the emulsion cross-linking method. The ionic gelat

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14

Gunda, Dr Raghavendra Kumar, and Dr Tirumala Devi Kolli. "DEVELOPMENT AND IN-VITRO ASSESSMENT OF DIVALPROEX SODIUM BILAYERED TABLETS." Journal of Applied Pharmaceutical Sciences and Research 7, no. 2 (2024): 46–52. http://dx.doi.org/10.31069/japsr.v7i2.08.

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Objective: The aim of the current research work is to develop a bi-layered Divalproex sodium tablet with an immediate release layer and a sustained release layer. Divalproex sodium is regarded as the most significant antiepileptic medication and is frequently used to treat bipolar illness, epilepsy, and migraine prevention. Methods: Wet granulation was used to prepare both (Immediate release, Sustained release) layers since Divalproex had poor flow properties. Superdisintegrants were used to produce the immediate release layer, which was then assessed for physical characteristics, disintegrati

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15

Ramya, Devoju, and Dr M. Sunitha Reddy. "Formulation and Evaluation of Sustained Release Pellets of Verapamil HCL." Saudi Journal of Medical and Pharmaceutical Sciences 8, no. 10 (2022): 536–41. http://dx.doi.org/10.36348/sjmps.2022.v08i10.007.

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Verapamil Hydrochloride, an antihypertensive agent which is used as a calcium channel blocker. The aim of the present study was to formulate and evaluate Verapamil HCL sustained release pellets. The work is to obtain Verapamil HCL sustained release pellets by using HPMC based polymers i.e., HPMC AN6, HPMC E5, HPMC E15 in the sustained release layer. The verapamil Hydrochloride has pH-dependent solubility. To overcome the pH dependent solubility Fumaric acid was used that which provides micro-acidic environment. Different Ratios of Ethyl-cellulose and HPMC polymers were used to optimise and eva

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16

Zhu, Xueqiang, Hanghang Ji, Gang Hua, and Lai Zhou. "Dynamic Release Characteristics and Kinetics of a Persulfate Sustained-Release Material." Toxics 11, no. 10 (2023): 829. http://dx.doi.org/10.3390/toxics11100829.

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Sustained-release materials are increasingly being used in the delivery of oxidants for in situ chemical oxidation (ISCO) for groundwater remediation. Successful implementation of sustained-release materials depends on a clear understanding of the mechanism and kinetics of sustained release. In this research, a columnar sustained-release material (PS@PW) was prepared with paraffin wax and sodium persulfate (PS), and column experiments were performed to investigate the impacts of the PS@PW diameter and PS/PW mass ratio on PS release. The results demonstrated that a reduction in diameter led to

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17

Deshmukh, Rutuja, Mrunal Waghulde, Satyendra Mishra, and Jitendra Naik. "Development and Characterization of Glipizide Loaded Sustained Release Nanoparticles." Current Nanomedicine 9, no. 3 (2019): 232–42. http://dx.doi.org/10.2174/2468187309666190620145438.

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Background: Treating the disease like diabetes is essential due to its wide range of spreading and heredity issues. Glipizide is the commonly used drug for the treatment of diabetes. Glipizide loaded sustained release nanoparticles have been developed to avoid repeated dosing. Objective: The study aimed to develop glipizide-loaded sustained release nanoparticles and characterize them for different studies. Methods: The aim of the present study was to develop glipizide-loaded sustained release nanoparticles using different polymers by the solvent evaporation method. The polymers; Eudragit (RS 1

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18

Satyendra, Singh Richa Solanki Yuvraj Singh Dangi Naina Dubey *. "FORMULATION, DEVELOPMENT AND EVALUATION OF DICLOFENAC SODIUM SUSTAINED RELEASE TABLET BY USING MELT GRANULATION TECHNOLOGY." Journal of Pharma Research 7, no. 11 (2018): 238–42. https://doi.org/10.5281/zenodo.1579484.

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<strong><em>ABSTRACT</em></strong> <strong><em>S</em></strong><em>ustained release (SR), sustained action (SA), extended release (ER, XR,OR XL), time release or timed release, controlled release  (CR), modification release (MR), or continuous release (CR), is a mechanism used in pill tablets or capsules to  dissolve slowly and release a drug over time. The advantages of sustained-release tablets or capsules are that they can often be taken less frequently then immediate-release formulation of the same drug, and that they keep steadier levels of the drug in the bloodstream. The presen

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19

Zhao, Hai-yang, Jiang Wu, Jing-jing Zhu, et al. "Research Advances in Tissue Engineering Materials for Sustained Release of Growth Factors." BioMed Research International 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/808202.

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Growth factors are a class of cytokines that stimulate cell growth and are widely used in clinical practice, such as wound healing, revascularization, bone repair, and nervous system disease. However, free growth factors have a short half-life and are instablein vivo. Therefore, the search of excellent carriers to enhance sustained release of growth factorsin vivohas become an area of intense research interest. The development of controlled-release systems that protect the recombinant growth factors from enzymatic degradation and provide sustained delivery at the injury site during healing sho

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20

Shaikh, Siraj Nawaj* Md. ZuberPatel G. J. Khan Patel M. Siddik ZakirShaikh. "DESIGN AND EVALUATION OF BILAYER FLOATING TABLETS OF DILTIAZEM HCL." ndo American Journal of Pharmaceutical SciencesI 04, no. 08 (2017): 2612–21. https://doi.org/10.5281/zenodo.858667.

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The present investigation concerns design and evaluation of bilayer floating tablets of Diltiazem HCl Diltiazem HCl is Class I drug, though its reported bioavailability is only 40 %. It is having very short half life of 3 to 4 hrs. Hence many sustained release formulations were developed for Diltiazem HCl. A direct compression method was used to formulate all batches. 32 factorial design was applied to study % cumulative drug release and hardness. Super disintigrants like Sodium starch glycolate was used for immediate release layer and HPMC K200 M, Xanthan gum like polymers were used in floati

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21

Gaware, Ravi U., Sujit T. Tambe, Shankar M. Dhobale, and Suresh L. Jadhav. "Formulation and in-vitro evaluation of theophylline sustained release tablet." Journal of Drug Delivery and Therapeutics 9, no. 1-s (2019): 48–51. http://dx.doi.org/10.22270/jddt.v9i1-s.2252.

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The aim of present study was to prepare sustained release tablet of Theophylline so as to prolong its elimination time and at the same time to keep cost of the formulation minimum. In this study ethyl cellulose and Eudragit are used in the formulation to sustain the release of Theophylline. Ethyl cellulose and Eudragit are added at the granulation step to form a sustained release coating around each granule. Different batches were designed one after another on trial and error basis to get the optimum drug release upto 12 hours. Keywords: Theophylline, ethyl cellulose, Eudragit, sustained

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22

Zhao, Jun, Longbiao Xu, Ming Zhao, and Chao Wei. "Preparation of Temozolomide Nano SustainedRelease Microsphere Material and Its Application in Treatment of Glioma." Science of Advanced Materials 12, no. 10 (2020): 1476–84. http://dx.doi.org/10.1166/sam.2020.3841.

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The polylactic acid/glycolic acid (PLGA) sustained-release microspheres are used as the main material for local sustained-release in the study. Ultrasonic emulsification-solvent evaporation method is applied to combine the sustained-release microspheres material with temozolomide to form a composite sustained-release microsphere (TMZ-PLGA-W). The ratio of lactic acid (LA) and glycolic acid (GA) was adjusted so as to test the morphological characteristics of TMZ-PLGA-W at different ratios. The amount of drug released and the encapsulation rate of the material at different time periods were calc

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23

Ravindra K., Kamble, Chauhan Chetan S., Kamble Priyadarshani R., and Naruka Pushpendra S. "Formulation Optimization of Sustained Release Resinate Microcapsules of Tramadol Hydrochloride by Using 3/2 Factorial Design." International Journal of Pharmaceutical and Phytopharmacological Research 6, no. 2 (2017): 57. http://dx.doi.org/10.24896/eijppr.2016621.

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The main aim of the present work was to develop the microcapsules of tramadol hydrochloride for the oral sustained release drug delivery. Tramadol hydrochloride a BCS class I drug a centrally acting synthetic analgesic was complexed with Indion 254 ion exchange resin. The microcapsules were prepared by encapsulating the prepared resinates by o/o solvent evaporation technique. In the investigation 32 full factorial design was used to investigate the joint influence of two formulation variable amount of eudragit RS 100 and plasticized PEG 400. The results of multiple linear regression analysis i

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24

Liu, Ping, and Jin Liang Zhang. "The Preparation and In Vitro Release Study of the Novel Changchun Amine Sustained-Release Capsules." Applied Mechanics and Materials 651-653 (September 2014): 313–16. http://dx.doi.org/10.4028/www.scientific.net/amm.651-653.313.

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Objective: to prepare sustained-release capsules, changchun amine build release degree determination method, study its drug release characteristics and compared with the reference preparation. Methods: using ordinary dissolution apparatus and fiber stripping analyzer to determine the in vitro release of sustained-release capsules. The content determination method, drug to pH 1.5 sodium chloride for the release of the medium of hydrochloric acid solution, using ultraviolet spectrophotometry to release a quantity, at the same time by optical real-time test evaluation of homemade consistency and

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Ruan, Li Li, Da Xin Wang, You Wei Zhang, Jiong Xin Zhao, Xiu Fang Zhang, and Nan Liang Chen. "Different pH-Values of Release Medium Influence the Drug Release from PTX-PCL Microspheres." Advanced Materials Research 482-484 (February 2012): 2605–8. http://dx.doi.org/10.4028/www.scientific.net/amr.482-484.2605.

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In this paper we study in vitro release of paclitaxel-loade polycaprolactone sustained-release microspheres. Different pH values release medium is used to simulate pH conditions in different parts of body, and determination the paclitaxel in Microspheres by High Performance Liquid Chromatography according Chinese Pharmacopoeia 2010. The experimental results indicate that the microspheres release rates of same drug loading content in buffer solution of pH 7.35 is the fastest, and in the pH 1.2 is the slowest. The drug release behavior according to the first-order model and it is not affected by

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N. Abd Al Hammid, Shaimaa. "Formulation and Evaluation of Lisinopril Double Layer Tablet." Tikrit Journal of Pharmaceutical Sciences 9, no. 2 (2023): 293–304. http://dx.doi.org/10.25130/tjphs.2013.9.2.13.293.304.

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Lisinopril is an antihypertensive drug that is primarily used in the treatment of hypertension, congestive heart failure, heart attacks and also in preventing renal and retinal complication of diabetes that acts by inhibiting angiotension converting enzyme (ACE). The present investigation deals with the formulation of lisinopril double layer tablet containing 100 mg fast release layer and 100 mg sustained release layer to be formulated using wet granulation method. Twelve formulations are prepared for bilayered tablets; 6 formulas for fast release layer study (FF1 to FF6) and another 6 formula

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Vaishnavi, Lawange Shubhangi Ugale Mahesh Mole. "Review on Formulation and Evaluation of Sustained Release Matrix Tablets." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 1977–86. https://doi.org/10.5281/zenodo.13101723.

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Recently, sustained release pharmaceutical products became a very useful tool in medical practice, offering a wide range of actual and perceived advantages to the patients. Sustained release is also providing promising way to decrease the side effect of drug by preventing the fluctuation of the therapeutic concentration of the drug in the body. Now a days as very few drugs are coming out of research and development and already existing drugs are suffering the problem of resistance due to their irrational use specifically in case of drugs like antibiotics. Hence, change in the operation is a su

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Addanki Anusha, Krishnaphanisri Ponnekanti, Ramanuj Tiwari, L. Swapna, Md Mabrur Hussain, and A Siddhardha. "A review of medicines with sustained release." World Journal of Biology Pharmacy and Health Sciences 13, no. 3 (2023): 221–33. http://dx.doi.org/10.30574/wjbphs.2023.13.3.0141.

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Sustained-release matrix tablets allow for continuous drug release while also optimizing a drug's biologic, pharmacokinetic, and pharmacodynamic properties for maximum therapeutic efficacy. The matrix regulates the rate at which the drug is released. Because it facilitates prolonged release, the major excipient in the formulation is a release retardant. The technology may promote patient compliance and efficiently treat chronic illnesses by decreasing the overall dosage and dosing schedule. The drug is supplied in this system via diffusion- and dissolution-controlled methods. The primary goal

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Acharya, Ankit, Mohammed Gulzar Ahmed, Ravi Chaudhari, and Renukaradhya Chitti. "Formulation and Development of Divalproex Sodium Bi-Layered Tablets using Superdisintegrants and Release Retardant Polymers." International Journal of Pharmaceutical Sciences and Nanotechnology 10, no. 2 (2017): 3669–75. http://dx.doi.org/10.37285/ijpsn.2017.10.2.5.

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 Divalproex sodium is considered as the most important antiepileptic drug and widely used for treatment of epilepsy and bi-polar disorders and prophylaxis of migraine. The present work has been done to formulate bi-layered tablet of Divalproex sodium containing immediate release layer and sustained release layer. The FTIR study revealed that there was no interaction between drug and polymer and combination. Both layers were prepared by wet granulation technique as poor flow property exhibited by pure drug. The immediate release layer was formulated by using superdisintegrants and evaluat

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Kodalkar, Swapnil J., Rohan A. Khutale, Sachin S. Salunkhe, Sachin S. Mali, and Sameer J. Nadaf. "Implementation of time release technology in formulation development and evaluation of sustained release tablet of Lornoxicam." Indian Journal of Pharmaceutical and Biological Research 2, no. 01 (2014): 68–75. http://dx.doi.org/10.30750/ijpbr.2.1.11.

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In present study, the attempts have been made to formulate sustained release tablets of lornoxicam by direct compression method. Based on viscosity grades different proportions of hydrophilic polymers (HPMC K4M, HPMC K15M, HPMC K100M) are used for preparation of lornoxicam sustained release matrix tablet. The drug excipient mixtures were subjected to preformulation studies comprising of micromeritic properties. The tablets were subjected to various studies like as physicochemical studies, in vitro drug release, kinetic studies, etc. FTIR studies shown there was no interaction between drug and

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Venkatesh, D. Nagasamy, Jawahar N., Ganesh G.N.K., et al. "Development and In vitro Evaluation of Sustained Release Matrix Tablets of Theophylline using Hydrophilic Polymer as Release Retardant." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 1 (2009): 450–56. http://dx.doi.org/10.37285/ijpsn.2009.2.1.9.

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In the present investigation, an attempt has been made to increase therapeutic efficacy, reduce frequency of administration and improve patient compliance by developing sustained release matrix tablets of theophylline. Sustained release matrix tablets of theophylline were developed by using drug and different concentrations of polymer such as 10, 20, 30, 40 and 50%. Hydroxypropylmethylcellulose (HPMC) was used as a matrix material and microcrystalline cellulose as diluent. All the lubricated formulations were compressed using 10 mm flat faced punches. Compressed tablets were evaluated for unif

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32

Addanki, Anusha, Ponnekanti Krishnaphanisri, Tiwari Ramanuj, Swapna L., Mabrur Hussain Md, and Siddhardha A. "A review of medicines with sustained release." World Journal of Biology Pharmacy and Health Sciences 13, no. 3 (2023): 221–33. https://doi.org/10.5281/zenodo.8036007.

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Sustained-release matrix tablets allow for continuous drug release while also optimizing a drug's biologic, pharmacokinetic, and pharmacodynamic properties for maximum therapeutic efficacy. The matrix regulates the rate at which the drug is released. Because it facilitates prolonged release, the major excipient in the formulation is a release retardant. The technology may promote patient compliance and efficiently treat chronic illnesses by decreasing the overall dosage and dosing schedule. The drug is supplied in this system via diffusion- and dissolution-controlled methods. The primary g

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33

Xu, Xuan, Wei Wei, Ping Tao, and Yan Zhang. "Preparation and Application of Sustained-Release Potassium Ferrate(VI)." Journal of Chemistry 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/640757.

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In this study, a composite system for the sustained release of potassium ferrate(VI) (sustained-release K2FeO4) was prepared and applied for water treatment. The objective of this research was to maximize the effectiveness of K2FeO4for water treatment by enhancing its stability using diatomite. The sustained-release K2FeO4was characterized using X-ray diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopy. The results indicated that no new crystal phase was formed during the preparation and some K2FeO4crystals entered the pores of the diatomite. From K2FeO4relea

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Menkudale, Amruta, Pankaj Khuspe, Kishor Otari, Manisha Khemnar, and Vaishali Kulkarni. "An Updated Review on Applications of Natural Polymers in Sustained Release Drug Delivery System." Journal of Advances in Pharmacy Practices (e-ISSN: 2582-4465) 2, no. 1 (2020): 45–49. https://doi.org/10.5281/zenodo.3674633.

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<em>Sustained release drug delivery system is area of interest for formulation scientists in pharmaceutical industry because of advantage of administering a single dose of a drug that is released for an extended period of time instead of numerous doses. SDDS have various advantages like it optimize biopharmaceutical, pharmacokinetic and pharmacodynamic properties of drug in order to increase its use, reduce adverse effects, cure the disease, decrease the frequency of administration and thus, increase the patient compliance, increase safety margin of potent drugs, reduce healthcare costs etc. T

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Vijay, R. Chakote* Mrunal K. Shirsat Deepak A. Joshi Mayuri M. Ban Gunesh N. Dhembre. "DESIGN AND DEVELOPMENT OF MATRIX TABLET OF LABETALOL HCL BY USING TAMARIND SEED POLYSACCHARIDE AS POLYMER." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 02 (2018): 805–14. https://doi.org/10.5281/zenodo.1174319.

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The objective of present work was to design and develop sustained release matrix tablets of anti-hypertensive drug Labetalol hydrochloride. Hydroxypropyl methyl cellulose K15, Sodium CMC, Xanthan gum and Tamarind seed polysaccharide used as a rate retarding polymer. Whereas Polyvinyl Pyrrolidone and Microcrystalline cellulose are used as granulating agent and diluent. The influence of variable concentration of polymers on the release rate of drug was investigated. The results of the present work point out that the rate of Labetalol hydrochloride release from polymers like Hydroxypropyl methyl

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Wani, Taha Umair, and Nisar Ahmad Khan. "Formulation of Carbopol Capsules for Sustained Release of Losartan Potassium." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 92–97. http://dx.doi.org/10.22270/jddt.v9i2-s.2468.

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Sustained release formulations have been extensively studied for their benefits in improving various physicochemical and pharmacokinetic properties of large number of drugs. The aim of this study was to develop and evaluate sustained release capsules of losartan potassium in order to provide drug release over a long period of time. This allows the drug much time for absorption in gastrointestinal tract (GIT) and hence may increase the bioavailability of the drug. Carbopol 971 P was used as rate controlling polymer for the preparation of capsules. The capsules were evaluated for matrix integrit

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Nagarani, B., and G. V. Radha. "Design and Characterization of Mangiferin Sustained-Release Tablets." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 04 (2023): 1209–12. http://dx.doi.org/10.25258/ijddt.13.4.15.

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Background: Mangiferin is a natural bioactive compound used for various pharmacological activities like antidiabetic, anticancer, and anti-inflammatory. Objective: The development of unique sustained-release matrix tablets of mangiferin is the purpose of the work that is being presented here. Method: In this study, an effort is made to formulate mangiferin sustained-release matrix tablets by combining the sustained-release polymers HPMC K100M, Kollidone@SR, Keltone LVCR. Mangiferin matrix tablets have been synthesized by wet granulation utilizing the lactose works as the diluent. Systems were

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Adedokun, Musiliu, Tenderwealth Jackson, Kelechi Uchegbu, and Anthony Attama. "ORAL GENTAMICIN PREPARATION USING SOLIDIFIED LIPID PARTICULATE DELIVERY SYSTEM." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 9 (2017): 22. http://dx.doi.org/10.22159/ijpps.2017v9i9.12278.

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Objective: Despite the broad pharmacological activity of gentamicin against a number of bacteria, it's very inadequate oral bioavailability due to poor intestinal membrane permeability has limited its formulation into oral dosage delivery system. This work was thus aimed at formulation and evaluation of gentamicin-loaded microemulsions based on preparation of lipid matrix for sustained release delivery.Methods: Oral gentamicin suspensions were prepared by emulsification method using Tween 80 as a mobile surfactant in the lipid matrix dispersion. The resultant oral suspensions were evaluated fo

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Galankar, Vipulata P., Ganesh D. Basarkar, Chandrashekhar D. Upasani, and Sunil V. Amrutkar. "Indomethacin-Loaded Nanosponges for Oral Delivery: Formulation Strategy, Optimization, and In-vitro Evaluation." International Journal of Drug Delivery Technology 15, no. 02 (2025): 01–07. https://doi.org/10.25258/ijddt.15.2.15.

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Chronic illnesses like arthritis cause pain and inflammation, requiring extended oral analgesic therapy. To reduce adverse reactions, active pharmaceutical ingredients are administered through sustained-release dosage forms. However, methods like matrix tablets, osmotic systems, and ion exchange resins have limitations. Nanotechnological approaches like nanosponges improve precision and accuracy in medication release manufacturing. Encapsulated formulations offer benefits like reduced side effects, varied dose options, non-irritating properties, and aesthetic appeal. Nanosponges are used in fo

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Deepthi, V. Phani, AMPAPURAM RAJESH PAVAN, G. Naresh Babu, and K. Sreenivasulu. "Formulation and Evaluation of Prulifloxacin Sustained Release Matrix Tablets." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 72–81. http://dx.doi.org/10.22270/jddt.v9i4.2974.

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Prulifloxacin is a chemotherapeutic antibiotic of Fluor quinolone drug used to treat a various urinary tract infections. It has short half-life, makes the sustained release (SR) forms extremely advantageous. Sustained release tablets results in increased bioavailability. The purpose of the present study was to develop a sustain release matrix drug delivery system (SR) containing Prulifloxacin as a model drug by using various proportions of polymers such as HPMC E15, HPMC K15. The sustained release formulations of Prulifloxacin were prepared by direct compression method. Optimization of formula

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Rangasamy, Manivannan, Venkata Krishna Reddy Palnati, and Lakshmi Narayana Rao Bandaru. "Formulation development and evaluation of voriconazole sustained release tablets." International Current Pharmaceutical Journal 2, no. 10 (2013): 165–69. http://dx.doi.org/10.3329/icpj.v2i10.16410.

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The present study involves in the formulation and evaluation of sustained release tablets of Voriconazole (250mg). The objective of the present study was to formulate Voriconazole sustained release tablets by wet granulation method by using natural (Xanthan gum, Karaya gum) and semi synthetic polymers (HPMC K100M). Lactose was used as diluting agent, Magnesium stearate was used as a lubricant and Talc was used as a glident. These sustained release tablets can release the drug up to 12 hours in predetermined rate. The formulated powder blend was evaluated for bulk density, tapped density, compr

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Swetanshu, ,., and Vijay Sharma. "Formulation, Optimization and Evaluation of Bilayer Tablet of Antihypertensive Drug." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 704–8. http://dx.doi.org/10.22270/jddt.v9i4.3098.

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Hypertension or high blood pressure occurs when the high cardiac output exerts pressure on the arterial wall as the blood flow increases. Bi-layer tablets are prepared with one layer of drug for immediate release while second layer designed to release drug later, either as second dose or in an extended release manner. Bi-layered tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances, and also for sustained release tablet in which one layer is immediate release as initial dose and second layer is maintenance dose. Bilayer tablet is suitable f

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Beg, Sarwar, Amit Kumar Nayak, Kanchan Kohli, Suryakanta Swain, and MS Hasnain. "Antimicrobial activity assessment of time-dependent release bilayer tablets of amoxicillin trihydrate." Brazilian Journal of Pharmaceutical Sciences 48, no. 2 (2012): 265–72. http://dx.doi.org/10.1590/s1984-82502012000200010.

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The aim of present study was the assessment of antimicrobial activity of prepared time-dependent release bilayer tablets of amoxicillin trihydrate and in vitro evaluation of drug release by antimicrobial assay using agar plate diffusion method. The bilayer tablets comprised of a delayed and sustained release layer. Direct compression method was used for the preparation of bilayer tablets containing Eudragit-L100 D55 as delayed release polymer, and HPMCK4M and HPMCK15 as sustained release polymers. The prepared bilayer tablets containing amoxicillin trihydrate were evaluated for hardness, thick

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Nikita, Bhosale, Velhal Atish, Redasani Vivek Kumar, Raut Poonam, and Varda Joshi. "An Overview Onsustained Release Formulations Using Solid Dispersion as Solubility Enhancement Technique." Asian Journal of Pharmaceutical Research and Development 11, no. 3 (2023): 84–91. http://dx.doi.org/10.22270/ajprd.v11i3.1257.

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Biopharmaceutical classification system is important for determining the bioavailability of the drug. Drugs that dissolve slowly in water can be effectively solid-dispersed to increase their bioavailability. The bioavailability issue can be due to insufficient solubility of permeability. The poorly water-soluble medication dissolves more quickly when combined with the water-soluble carriers used to make solid dispersion. The review paper concentrates on the preparation techniques, benefits, drawbacks, and characterization of solid dispersion. Pharmaceuticals with sustained release have recentl

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Ding, Chengshi, Haidan Bi, Deya Wang, et al. "Preparation of Chitosan/Alginate-ellagic Acid Sustained-release Microspheres and their Inhibition of Preadipocyte Adipogenic Differentiation." Current Pharmaceutical Biotechnology 20, no. 14 (2019): 1213–22. http://dx.doi.org/10.2174/1389201020666190809110511.

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Objective: In this study, chitosan/alginate-ellagic acid sustained-release microspheres were prepared, and the effect of sustained-release microspheres on preadipocyte adipogenic differentiation was analyzed. Methods: Chitosan/alginate-ellagic acid microspheres were prepared and identified by scanning electron microscopy (SEM) and infrared spectroscopy (IR). The drug release rates were measured at pH 6.8, 7.0, 7.2, 7.4 to determine sustained release of ellagic acid from microspheres. The effects of 0.1, 1, 10 mg/L chitosan/alginate-ellagic acid microsphere on 3T3-F442A preadipocyte proliferati

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Ferreira, Guilherme Neves, Marcos Giovani Rodrigues Silva, Aline Guerra Manssour Fraga, et al. "Preparation and scale up of extended-release tablets of bromopride." Brazilian Journal of Pharmaceutical Sciences 50, no. 2 (2014): 291–300. http://dx.doi.org/10.1590/s1984-82502014000200008.

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Reproducibility of the tablet manufacturing process and control of its pharmaceutics properties depends on the optimization of formulation aspects and process parameters. Computer simulation such as Design of Experiments (DOE) can be used to scale up the production of this formulation, in particular for obtaining sustained-release tablets. Bromopride formulations are marketed in the form of extended-release pellets, which makes the product more expensive and difficult to manufacture. The aim of this study was to formulate new bromopride sustained release formulations as tablets, and to develop

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Mwila, Chiluba, and Roderick B. Walker. "Improved Stability of Rifampicin in the Presence of Gastric-Resistant Isoniazid Microspheres in Acidic Media." Pharmaceutics 12, no. 3 (2020): 234. http://dx.doi.org/10.3390/pharmaceutics12030234.

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The degradation of rifampicin (RIF) in an acidic medium to form 3-formyl rifamycin SV, a poorly absorbed compound, is accelerated in the presence of isoniazid, contributing to the poor bioavailability of rifampicin. This manuscript presents a novel approach in which isoniazid is formulated into gastric-resistant sustained-release microspheres and RIF into microporous floating sustained-release microspheres to reduce the potential for interaction between RIF and isoniazid (INH) in an acidic environment. Hydroxypropyl methylcellulose acetate succinate and Eudragit® L100 polymers were used for th

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Thapa, Chhitij, and Roma Chaudhary. "Formulation and In-Vitro Evaluation of Sustained Release Matrix Tablets of Domperidone." Journal of Universal College of Medical Sciences 8, no. 02 (2020): 40–45. http://dx.doi.org/10.3126/jucms.v8i02.34286.

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INTRODUCTION Domperidone is a unique compound with gastro kinetic and antiemetic effects. It is used in the management of disorder by impaired motility like gastroesophageal reflux (in some instances), gastroparesis, dyspepsia, heartburn, epigastric pain, nausea, vomiting, and colonic inertia. The sustained release system is a widely accepted approach for slow drug release over an extended period to address the challenges of conventional oral delivery, including dosing frequency, drug safety, and efficacy. The study aims to formulate a domperidone sustained release tablet and compare the

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Patel, Dhaval M., Riddhi Trivedi, and Hardik Patel. "Formulation and Evaluation of Bi-Layer Tablets of Ketorolac Tromethamine." Journal of Drug Delivery and Therapeutics 11, no. 1 (2021): 36–41. http://dx.doi.org/10.22270/jddt.v11i1.4487.

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The objective of the present study was to develop and evaluate bi-layer tablets of Ketorolac tromethamine, a nonsteroidal antiinflammatory drug with short half-life, that are characterized by initial burst drug release in the stomach and comply with the release requirements of sustained-release products. Each of the proposed bi-layer tablets is composed of an immediate-release layer and a sustained-release layer, anticipating rapid drug release that starts in the stomach to rapidly alleviate the symptoms and continues in the intestine to maintain protracted analgesic effect. Gastro retentive B

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Heyam, Saad Ali, Saad Rasha, M. A. Elhaj Babiker, Khan Jiyauddin, Kaleemullah Mohammed, and Al-Dhalli Samer. "Effect of Different Parameters on the Release of Diclofenac Modified Tablets." International Journal of Current Pharmaceutical Review and Research 8, no. 2 (2017): 192–97. https://doi.org/10.5281/zenodo.12677968.

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In the present study the influence of designing and development of sustained release (SR) matrix tablets of diclofenacsodium were investigated. The aim was to increase therapeutic efficacy, reduce frequency of administration, and improvepatient compliance. Sustained release matrix tablets of diclofenac sodium, were developed by using different drug: gumratios, using Xanthan gum as matrix former, microcrystalline cellulose as diluent and Polyethylene Glycol (PEG 6000) asrelease modifier. Formulated tablets were evaluated for friability, hardness, thickness and their relation to the amount ofgum

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