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Dissertations / Theses on the topic 'ITGAL'

Author: Grafiati

Published: 1 February 2025

Last updated: 31 July 2025

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1

Idani, Aida. "A multiomics approach to primary immunodeficiencies in human." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ061.

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Les déficits immunitaires primitifs sont un groupe de troubles causés par des mutations monogéniques dans des gènes jouant un rôle clé dans le développement et la fonction du système immunitaire. Dans cette thèse, une approche multiomique a été adoptée pour étudier deux gènes associés à ces conditions, afin d'élucider davantage les mécanismes par lesquels les variants pathogènes nuisent au système immunitaire. Le premier sujet était HYOU1, défini comme un gène dont les défauts causent un déficit immunitaire primitif. Nous avons observé une hypogranularité dans les neutrophiles du patient et ré

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2

Heller, Kristin Noreen. "Alternative to Gene Replacement for Duchenne Muscular Dystrophy using Human Alpha7 Integrin (ITGA7)." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1388401639.

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3

GAMBELLI, ALICE. "ITGA6 is a key molecule in driving metastatization of platinum resistant epithelial ovarian cancer." Doctoral thesis, Università degli Studi di Trieste, 2022. http://hdl.handle.net/11368/3014977.

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Epithelial ovarian cancer (EOC) is a relatively rare disease usually diagnosed in advanced stages (III and IV stage). Standard of care includes radical surgery followed by platinum-based chemotherapy. Yet, 15% to 30% of EOC patients have a primary platinum-resistant or refractory disease and more than 70% of originally platinum-sensitive advanced stages patients will develop a resistant disease disseminated in the abdomen and pelvis. For these reasons, the net five-year survival by stage is only of 26% and 13% for stage III and IV, respectively. The resistance to chemotherapy is one of the maj

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4

Mokrani, M'barka. "CD103 : du gène à la protéine : Etude de la régulation et de la signalisation de l’intégrine αE(CD103)β7 exprimée par les lymphocytes T CD8+ intratumoraux". Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T071.

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L’élucidation des mécanismes permettant l’optimisation de la réponse immunitaire antitumorale correspond à un enjeu majeur pour le développement de stratégies d’immunothérapie efficace. En effet, les réponses immunitaires antitumorales se traduisent rarement par l’éradication de la tumeur. Dans ce contexte, les travaux antérieurs de mon équipe ont démontré que l’interaction de l’intégrine αE(CD103)β7, souvent exprimée par les lymphocytes infiltrant la tumeur (TIL), avec son ligand E-cadhérine, à la surface des cellules tumorales épithéliales, joue un rôle majeur dans la potentialisation de l’a

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5

Hsieh, Jenny [Verfasser], Rolf [Akademischer Betreuer] Marschalek, and Theodor [Akademischer Betreuer] Dingermann. "Funktionelle Analyse des MLH1·ITGA9-Fusionsproteins einer Lynch-Syndrom-Familie / Jenny Hsieh. Gutachter: Rolf Marschalek ; Theodor Dingermann. Betreuer: Rolf Marschalek." Frankfurt am Main : Univ.-Bibliothek Frankfurt am Main, 2012. http://d-nb.info/1044093447/34.

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6

Pilati, Filippo. "I "Fatti di Cesare" nel Veneto e le "Zesarie batalie romane" del ms. Canon. Ital. 136 di Oxford." Doctoral thesis, Università di Siena, 2020. http://hdl.handle.net/11365/1105152.

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Questa tesi si pone l’obiettivo di studiare la fortuna e la circolazione nel Veneto dei "Fatti di Cesare", con una proposta di edizione critica delle inedite "Zesarie batalie romane contenute nel ms. Oxford, Bodleian Library, Canonicianus Italicus 136. Nel fare questo si è anzitutto offerto, nella parte I di questo lavoro, una disamina attenta dei numerosi volgarizzamenti italiani dei "Faits des Romains", con l’ampia discussione della bibliografia esistente sulla questione e un riesame complessivo delle diverse testimonianze manoscritte, unito anche a un controllo sulla tradizione del testo fr

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7

Holtkötter, Olaf. "Inaktivierung des ITGA2-Gens in der Maus neue Erkenntnisse über die Funktion des [alpha]2[beta]1-Integrinrezeptors [alpha2beta1-Integrinrezeptors] in vivo /." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=966631803.

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8

Maestrello, Chadia Chahud. "Produção de celulases e xilanases pelo fungo Aspergillus labruscus ITAL 22.223 cultivado em fermentação em estado sólido utilizando resíduos agroindustriais /." Araraquara, 2018. http://hdl.handle.net/11449/153200.

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Orientador: Luis Henrique Souza Guimarães<br>Banca: Daniela Alonso Bocchini<br>Banca: Valéria de Carvalho Santos Ebinuma<br>Resumo: A prospecção de enzimas fúngicas tem sido amplamente estudada nos ultimos anos, principalmente utilizando a Fermentação em Estado Sólido (FES). A procura por enzimas microbianas, principalmente de fungos filamentosos, capazes de degradar material lignocelulósico, tem despertado grande interesse para processos biotecnológicos como, por exemplo, na produção de bioetanol, a partir do bagaço de cana-de-açúcar. Fungos do gênero Aspergillus são reconhecidos como ótimos

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9

Cuneo, Passalacqua Gian Piero, and Miranda Juan José Ricaldi. "Incremento de la productividad de tabiques de albañilería confinada utilizando el sistema constructivo de bloques apilables en seco y autoencajables Ital Block." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2019. http://hdl.handle.net/10757/629501.

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El objetivo principal de la presente investigación es idear un sistema que logre disminuir el costo y el tiempo de elaboración de muros no portantes de albañilería confinada. Para lograrlo se ha diseñado un sistema de bloques de arcilla apilables en seco y autoencajables que cumple con todas las normas imputables. Para determinar el rendimiento del sistema diseñado se fabricaron las piezas y se construyó un muro con medidas típicas. Los resultados para dicho caso de estudio se resumen en un ahorro de 17% en el costo directo (considerando todo el muro en su conjunto) y 76% en el tiempo emp

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10

Leibnitz, Alexander [Verfasser], Oliver [Akademischer Betreuer] Gross, and Wolfgang [Akademischer Betreuer] Krick. "Einfluss der Kollagenrezeptoren ITGA2 und DDR1 in der Pathogenese von glomerulären Nierenerkrankungen am Doppelknockout-Tiermodell / Alexander Leibnitz. Gutachter: Oliver Gross ; Wolfgang Krick. Betreuer: Oliver Gross." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://d-nb.info/1051977223/34.

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11

Talbot, Jared Coffin 1982. "Patterning and Stabilizing the Zebrafish Pharyngeal Arch Intermediate Domain." Thesis, University of Oregon, 2011. http://hdl.handle.net/1794/11982.

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xv, 76 p. : ill. (some col.) Includes 4 video files.<br>Improved understanding of pharyngeal arch (PA) patterning and morphogenesis can reveal critical insights into the origins of craniofacial diseases, such as Fraser syndrome. PAs contain mesenchymal condensations, which give rise to most of the facial skeleton in vertebrates. Studies of Endothelin1 signaling reveal that the skeleton derived from the first two PAs are patterned into dorsal, intermediate, and ventral domains. Previous work has indicated that endothelin targets, including the Dlx genes, homeotically pattern dorsal versus ventr

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12

Masià, Fontana Anna. "El papel de la vía Notch en Rabdomiosarcoma." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/121513.

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El Rabdomiosarcoma (RMS) es el tumor de partes blandas más común en la infancia. Los pacientes con enfermedad diseminada continúan teniendo un mal pronóstico a pesar del uso de terapias intensivas. En este trabajo se evidencia la expresión y activación notable de la vía Notch en RMS y se demuestra la implicación de la vía como elemento clave en la regulación de mecanismos de adhesividad, movilidad e invasividad en células de RMS. Además se propone un mecanismo de regulación de estos procesos, mediado por Notch, a través de la regulación positiva de varias moléculas de adhesión, tales como la

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13

Chin, SP. "Regulation of the ITGA2 Gene in prostate cancer." Thesis, 2014. https://eprints.utas.edu.au/18568/1/Whole-Chin-thesis.pdf.

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Prostate cancer is the most commonly diagnosed cancer in males and is the second leading cause of cancer deaths in men after skin cancer. It is still associated with significant mortality and morbidity and statistics indicate that 80% of prostate cancer deaths have metastatic bony lesions. Previous work from our group has identified integrin alpha 2 (ITGA2) as a putative prostate cancer susceptibility gene through a familial genetic study. There is an increasing body of evidence suggesting it is involved in prostate cancer progression, particularly contributing to the preferential metastasis o

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14

Verhoeff, TJ. "Epigenetic regulation of the integrin ITGA2 in breast cancer." Thesis, 2018. https://eprints.utas.edu.au/47109/1/Verhoeff_whole_thesis.pdf.

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Breast cancer (BC) is the most commonly diagnosed and second greatest contributor to cancer deaths in women. Mortality is usually associated with the development of metastases with breast, like prostate cancer, having higher levels of bone metastases relative to other cancers. In fact 70% of terminal BC patients have bone lesions. Integrin α2β1, and specifically the α2 subunit (ITGA2), have altered expression in cancers, including BC, with implications in metastasis, angiogenesis, cell adhesion and survival. The integrin’s main function is ligation to collagens and laminin. Despite some regula

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15

Phillips, JL. "Regulation of ITGA6 and ITGB4 integrin genes by RUNX1 and epigenetic mechanisms." Thesis, 2017. https://eprints.utas.edu.au/23900/1/Phillips_whole_thesis.pdf.

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Disruption to regulatory mechanisms controlling gene expression is a hallmark of leukaemia, with disruption to transcription factors being one of the most prevalent. By identifying the gene expression profile under the control of these transcription factors, and understanding how the target genes are regulated, critical insight can be gained into the role of these transcription factors in haematopoiesis, as well as their role in leukaemia development. Evidence presented here suggests that the RUNX1 transcription factor regulates the expression of the α6β4 integrin receptor in haematopoietic ce

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16

Li, Yen Liang, and 黎彥良. "Transcriptomic analyses identify ITGA6 and GDF15 contributing to radioresistance in head-neck cancer." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/67486930570333855678.

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17

Gutierrez, Borda Felipe. "Plan de marketing para el posicionamiento de Ital Parquet en Colombia." Master's thesis, 2015. http://hdl.handle.net/10400.26/15362.

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El proyecto de disertación “PLAN DE MARKETING PARA EL POSICIONAMIENTO DE ITALPARQUET EN COLOMBIA”, es un proyecto basado en una empresa constituida desde 2011 en Bogotá, Colombia. Una empresa importadora y comercializadora de pisos en Madera, laminado, linoleum, Pvc, exteriores y guarda escobas. Durante estos dos primeros años la empresa ha venido desarrollando toda su estructura organizacional para poder empezar a introducir su marca como Importadora y Comercializadora de pisos en Madera italianas en Colombia. Sin embargo, al no tener una experiencia en el mercado colombiano esas barreras d

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18

Leibnitz, Alexander. "Einfluss der Kollagenrezeptoren ITGA2 und DDR1 in der Pathogenese von glomerulären Nierenerkrankungen am Doppelknockout-Tiermodell." Doctoral thesis, 2014. http://hdl.handle.net/11858/00-1735-0000-0022-5EA7-8.

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Die Mehrheit chronischer Nierenerkrankungen wird durch glomeruläre Defekte hervorgerufen. In dieser Arbeit wurde deshalb im Mausmodell die Bedeutung der Kollagenrezeptoren DDR1 (Discoidin Domain Rezeptor 1) und ITGA2 (Integrin Alpha 2) in der Pathogenese von glomerulären Nierenerkrankungen untersucht. Von zentralem Interesse waren neben der Betrachtung des renalen Phänotyps, die Analyse der glomerulären Basalmembran sowie die Prüfung auf Vorhandensein nierenschädigender Faktoren. Zur Orientierung angefertigte H.E.-Färbungen waren lichtmikroskopisch unauffällig, jedoch ließ sich mittels Gelelek

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19

Yu, Chun-Wei, and 游淳惟. "Using Bioinformatics Tools to Design an Anti-ITGA2 Antibody for Inhibiting Gastric Cancer Cell Growth." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/86994073822041533142.

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20

Holtkötter, Olaf [Verfasser]. "Inaktivierung des ITGA2-Gens in der Maus : neue Erkenntnisse über die Funktion des α2β1-Integrinrezeptors [alpha2beta1-Integrinrezeptors] in vivo / vorgelegt von Olaf Holtkötter". 2002. http://d-nb.info/966631803/34.

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21

AGHELU, MARIALAURA. "L'esperienza poetica di Simone Serdini da Siena (il Saviozzo). Con il commento della silloge tràdita dal ms. Marciano Ital. IX. 347 (=6483)." Doctoral thesis, 2019. http://hdl.handle.net/11573/1327799.

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Il lavoro definitivo risultante dalla ricerca svolta nel corso triennale di Dottorato consiste in un’indagine sulla figura del poeta Simone Serdini da Siena, detto il Saviozzo (1360 ca.-1410 ca.) concretizzatasi in un’ipotesi di lettura generale della sua produzione poetica e di commento delle sue rime, e più in particolare dei testi del ms. Marciano Ital. IX. 347 (=6483).

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22

DUNI, Matteo. "Tra religione e stregoneria ecclesiastici e pratiche magiche a Modena nel XVI secolo." Doctoral thesis, 1999. http://hdl.handle.net/1814/5783.

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Defence date: 15 October 1999<br>Examining Board: Prof. Robert Rowland, ISCTE, Lisbona (supervisor) ; Prof. Antonio Rotondó, Università di Firenze (co-supervisore) ; Prof. Ottavia Niccoli, Università di Trento ; Prof. Gérard Delille, IUE<br>PDF of thesis uploaded from the Library digitised archive of EUI PhD theses completed between 2013 and 2017

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