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Dissertations / Theses on the topic 'Its natural product and pharmaceutics'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Fang, Chao. "Synthetic Studies Toward Marine Natural Product Okadaic Acid and Its Analogs." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306336570.

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2

Saunders-Mattingly, Meredith A. "DISCOVERY OF NATURAL PRODUCT ANALOGS AGAINST ETHANOL-INDUCED CYTOTOXICITY IN HIPPOCAMPAL SLICE CULTURES." UKnowledge, 2018. https://uknowledge.uky.edu/psychology_etds/142.

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An estimated 13.9% of Americans currently meet criteria for an alcohol (ethanol; EtOH) use disorder (AUD). While there are 4 medications approved by the Food and Drug Administration (FDA) to treat AUD, these treatments have demonstrated poor clinical efficacy. Our ongoing research program encompasses a multi-tiered screening of a natural product library and validation process to provide novel information about the mechanisms underlying EtOH-induced changes in neurobiology and to identify novel chemical scaffolds to be exploited in the development of pharmacological treatments for AUD in a rode

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3

Lavallée, Vincent Paul. "Antipain and its analogues, natural product inhibitors of cathepsin K isolated from streptomyces." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/33846.

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In human bone, 90% of organic bone matrix is composed of type 1 collagen. Cathepsin K is a cysteine protease involved in osteoclast mediated bone absorption and has been identified as a major drug target for the treatment of osteoporosis. Numerous potent inhibitors of cathepsin K have already been identified from natural sources including epoxide inhibitors such as E-64 isolated from the fungi Aspergillus japonicus as well as various peptide aldehydes such as Leupeptin and alpha-MAPI purified from Streptomyces. 350 soil and lichen-associated bacterial strains collected in the rain forests of B

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4

Ralston, Kevin John. "Studies towards the total synthesis of disorazole C1 and its analogues." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9954.

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Structure-activity relationships (SARs) in the disorazole family have been revealed through the biological testing of natural disorazoles and their synthetic analogues, but little is known about the contribution of the oxazole to the anti-tubulin activity of disorazole C1 I. The development of a novel Evans-Tishchenko/alkyne metathesis (ET-AM) route towards the synthesis of disorazole C1 will provide straightforward access to disorazole C1 and its heterocyclic analogues, thus allowing the contribution of the oxazole to the natural product's bioactivity to be elucidated. Our ET-AM approach offe

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5

Yang, Fan. "Chemotaxonomy Study of Plants from the Family Proteaceae Based on Its Natural Product Profile (Alkaloid)." Thesis, Griffith University, 2017. http://hdl.handle.net/10072/367627.

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The Proteaceae is a flowering plant family containing approximately 1700 species across more than 80 genera and is a predominant feature of Australian and South African flora. The chemistry of plants from the family has been studied by researchers for over a century but these studies have neither been systematic nor extensive. The research carried out in this thesis has firstly systematically reviewed and synthesized the current state of knowledge with regard to the natural products chemistry of the Proteaceae in relation to taxonomic groupings derived from molecular and morphometric phylogene

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6

Das, Anushree. "Photogeneration Mechanism of Reactive Intermediate and its Applications in Photoremovable Protecting Group and Natural Product Synthesis." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1479814832756981.

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7

Kumarn, Sirirat. "A highly selective organocatalytic route to chiral 1,2-oxazines and 3,6-dihydropyridazines and its application in natural product synthesis." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612392.

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8

Cheng, Jiye. "Development of a Metabolomics Strategy for Novel Natural Product Discovery and its Application to the Study of Soybean Defense Responses." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1307389510.

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9

Napan, Kandy L. "Investigation of the Tailoring Steps in Pradimicin Biosynthesis." DigitalCommons@USU, 2016. https://digitalcommons.usu.edu/etd/4730.

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The actinobacteria Actinomadura hibisca synthesizes the natural products pradimicin A-C through a type II polyketide biosynthetic pathway. Eight tailoring enzymes in pradimicin biosynthesis have been investigated in this work, including PdmJ, PdmW, PdmN, PdmT, PdmO, PdmS, PdmQ and PdmF. PdmJ and PdmW were characterized as cytochrome P450 hydroxylases that catalyze the incorporation of two hydroxyl groups at C-5 and C-6, respectively. These enzymes worked synergistically and their co-expression significantly improved the efficiency of the hydroxylation steps. PdmN is an amino acid ligase that a

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10

Lehner, Verena [Verfasser], and Oliver [Akademischer Betreuer] Reiser. "Rh(II)-catalyzed Cyclopropanation of Aromatic Heterocycles and its Application to the Total Synthesis of Natural Product Derivatives / Verena Lehner ; Betreuer: Oliver Reiser." Regensburg : Universitätsbibliothek Regensburg, 2017. http://d-nb.info/1168903033/34.

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11

Lee, Robert J. "A biosynthetically-inspired synthetic route to substituted furans and its application to the total synthesis of the furan fatty acid F5." Thesis, Loughborough University, 2018. https://dspace.lboro.ac.uk/2134/36252.

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Dietary fish oil supplementation has long been shown to have significant health benefits, largely stemming from the anti-inflammatory activity of the ω-3 and ω-6 polyunsaturated fatty acids (PUFAs) present in fish oils. The anti-inflammatory properties of these fatty acids has been linked to beneficial health effects, such as protecting the heart, in individuals consuming diets rich in fish, or supplemented with fish oils. These effects are highly notable in the Māori people native to coastal regions of New Zealand; the significantly lower rates of heart problems compared to the inland populo

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12

Lin, Jun [Verfasser], Axel A. [Gutachter] Brakhage, Miriam [Gutachter] Rosenbaum, and Oskar [Gutachter] Zelder. "Development of a user-friendly heterologous expression system and its applications for natural product biosynthesis / Jun Lin ; Gutachter: Axel. A. Brakhage, Miriam Rosenbaum, Oskar Zelder." Jena : Friedrich-Schiller-Universität Jena, 2020. http://d-nb.info/1225397413/34.

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13

Flanigan, David L. Jr. "Studies in Rhodium Catalyzed Intramolecular C-H Insertion of Amino Acid Derived α-Diazo-α-(substituted)acetamides and its Application to the Total Synthesis of clasto-Lactacystin β-Lactone". Scholar Commons, 2004. https://scholarcommons.usf.edu/etd/1037.

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Lactacystin is a microbial metabolite isolated by Omura that exhibits neurotrophic activity in neuroblastoma cell lines. Lactacystin and especially its β-lactone analog are the first examples of non-polypeptide small molecules capable of specifically inhibiting the 20S proteasome. Various asymmetric total syntheses of lactacystin and its analogs have been reported. The total synthesis of clasto -lactacystin β-lactone is achieved using L-serine methyl ester as the starting material and the sole source of stereochemical induction. The success of this synthesis hinges on two featured transformati

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14

Huber, Tyler D. "TOWARD AN ENZYME-COUPLED, BIOORTHOGONAL PLATFORM FOR METHYLTRANSFERASES: PROBING THE SPECIFICITY OF METHIONINE ADENOSYLTRANSFERASES." UKnowledge, 2019. https://uknowledge.uky.edu/pharmacy_etds/106.

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Methyl group transfer from S-adenosyl-l-methionine (AdoMet) to various substrates including DNA, proteins, and natural products (NPs), is accomplished by methyltransferases (MTs). Analogs of AdoMet, bearing an alternative S-alkyl group can be exploited, in the context of an array of wild-type MT-catalyzed reactions, to differentially alkylate DNA, proteins, and NPs. This technology provides a means to elucidate MT targets by the MT-mediated installation of chemoselective handles from AdoMet analogs to biologically relevant molecules and affords researchers a fresh route to diversify NP scaffol

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15

Peng, Ge. "A novel tin-mediated indole synthesis and its application to natural product synthesis." Thesis, 1996. http://hdl.handle.net/1911/16930.

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A new indole synthesis is described. The key step involves a novel tin-mediated free radical reaction to generate unstable 2-tri-n-butylstannyl-3-substituted indoles, which upon mild acidic workup, furnishes 3-substituted indoles. The 2-tri-n-butylstannyl-3-substituted indoles are also subjected to a one-pot Stille coupling to provide 2,3-disubstituted indoles. Two applications of the above methodology are also described. The efficient total synthesis of (${\pm})$-vincadifformine involves the construction of the indole skeleton by using this indole formation reaction and a novel amine protecti

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16

Gerasyuto, Aleksey Igorevich. "Development of intramolecular aza- [3 + 3] annulation reaction and its applications in natural product synthesis." 2007. http://www.library.wisc.edu/databases/connect/dissertations.html.

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17

Liu, Yu-Liang, and 劉昱良. "Anti-inflammatory activities of a Fatsia polycarpa natural product and its derivative." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/65425900851634577691.

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碩士<br>國立屏東科技大學<br>生物科技系所<br>101<br>Fatsia polycarpa is an evergreen shrub plant endemic to Taiwan. Its foliage is used in traditional medicine to treat cold, coughing, and rheumatoid arthritis; its twig is used in pain relief and improving blood circulation. However, the effective constituents in its extract are not clear. Previously, nine oleanane-type triterpenoids were isolated from the leaves and twigs of Fatsia polycarpa. Among them, 3α-hydroxylean-11,13 (18)-dien-28-oic acid (HODA) is one of the abundant triterpenes. In this study, the anti-inflammatory effects of HODA and its acetylated

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18

Young, Christopher. "The Depth of a Hopf algebra in its Smash Product." Doctoral thesis, 2014. https://repositorio-aberto.up.pt/handle/10216/102331.

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19

Young, Christopher. "The Depth of a Hopf algebra in its Smash Product." Tese, 2014. https://repositorio-aberto.up.pt/handle/10216/102331.

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20

Chia, Cho-Yun, and 賈卓昀. "Studies on angiogenesis of natural product WJO00 and its derivatives in human endothelial progenitor cell." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/03513573841628273943.

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21

Chen, Chih-ching, and 陳志清. "1. A New Approach to 3,4-Disubstituted Succinimides and Its Applications in Natural Product Synthesis2. A New Approach to (E)-3-Substituted-N-alkyl Acrylamides and Its Applications." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/4t2n5c.

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博士<br>國立中山大學<br>化學系研究所<br>96<br>1. We have explored a formal [3+2] strategy that is synthetically useful for constructing 3,4-disubstituted succinimides with ethyl bromoacetate derivatives or methyl glyoxylate in one step. 2. We reported a new approach to (E)-β-aryl-α,β-unsaturated amides. Instead of using aldehydes, phosphorus, silicon containing compounds and metal catalysts for the synthesis of double bonds, α-sulfonyl acetamide and various benzyl bromides were used as starting materials

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22

Tambar, Uttam Krishan. "Convergent Methods for Synthesizing Rings in the Context of Natural Product Synthesis: I. Development of a Tandem Stille-Oxa-Electrocyclization Reaction, and Progress Toward the Total Synthesis of Saudin. II. Development of the Direct Acyl-Alkylation of Arynes, and Its Application Toward the Total Synthesis of Amurensinine." Thesis, 2006. https://thesis.library.caltech.edu/5107/1/00_Tambar_intro.pdf.

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<p>Cyclic molecular structures are ubiquitous in chemistry. Efficient and convergent methods to synthesize these rings are of great importance, specifically in the context of natural product synthesis. The development of two methods for the synthesis of the core structures of the natural products saudin and amurensinine are described.</p> <p>First, the development of the tandem Stille-oxa-electrocyclization will be discussed in the context of synthetic efforts with saudin. The labdane diterpenoid saudin was isolated in 1985 by Mossa and Cassady from the leaves of the Clutia richardiana (

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