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Journal articles on the topic 'Its natural product and pharmaceutics'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Atiur, Ahmed. "A review on recent advances in the synthesis of indole and its analogs via C-H activation as a key step." Journal of Indian Chemical Society Vol. 97, No. 9b, Sept 2020 (2020): 1426–41. https://doi.org/10.5281/zenodo.5656702.

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Memari College, Memari, Purba Bardhaman-713 146, West Bengal, India <em>E-mail: </em>atiur.chem@gmail.com <em>Manuscript received online 09 July 2020, accepted 28 August 2020</em> Indole is widely found as the building block in various pharmaceuticals, natural products, agrochemicals, dyes and fragrances. Thus chemists were attracted in developing new methods to prepare this moiety. Over the years, various strategies including C-H activation have been employed to afford these heterocycles. Therefore the continuous updates of the new approaches developed are essential. In this review, significa

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Dias, Lucas D., Fernanda Mansano Carbinatto, Isabelle da Silveira Almeida, et al. "Eco-Friendly Extraction of Green Coffee Oil for Industrial Applications: Its Antioxidant, Cytotoxic, Clonogenic, and Wound Healing Properties." Fermentation 9, no. 4 (2023): 370. http://dx.doi.org/10.3390/fermentation9040370.

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The development of natural oil-based cosmetic and pharmaceutical products presents great scientific and commercial interest. Herein, we aimed to extract green coffee oil from Arabic coffee by a sustainable cold-pressing method. Furthermore, this work aimed to characterize the obtained green coffee oil by Fourier-Transform Infrared (FT–IR) and ultraviolet–visible spectroscopies (UV–Vis), peroxide analysis, and fatty acids profile by gas chromatography–mass spectrometry (GC–MS). Moreover, the functional and biological properties of the obtained green coffee oil and a green-coffee oil-based comme

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Ramezani, Moazzameh, Melika Hasani, Fatemeh Ramezani, and Mahmood Karimi Abdolmaleki. "Cucurbitacins: A Focus on Cucurbitacin E As A Natural Product and Their Biological Activities." Pharmaceutical Sciences 27, no. 1 (2020): 1–13. http://dx.doi.org/10.34172/ps.2020.66.

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For the last years, different types of cucurbitacins have been extracted from various species of Cucurbitaceae family. For this review, all related papers were accumulated by searching electronic databases in the English language, including PubMed, Scopus, and Google Scholar. The keywords of cucurbitacin, cucumber anticancer therapy, cytotoxic effects, chemotherapy, and inhibitor effect were searched until February 2020. According to the result of this review, cucurbitacin E as a tetracyclic triterpenes compound, has been exhibited cell cycle arrest, anti-inflammatory and anticancer activities

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Zhu, Saibin, Yanwen Duan, and Yong Huang. "The Application of Ribosome Engineering to Natural Product Discovery and Yield Improvement in Streptomyces." Antibiotics 8, no. 3 (2019): 133. http://dx.doi.org/10.3390/antibiotics8030133.

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Microbial natural product drug discovery and development has entered a new era, driven by microbial genomics and synthetic biology. Genome sequencing has revealed the vast potential to produce valuable secondary metabolites in bacteria and fungi. However, many of the biosynthetic gene clusters are silent under standard fermentation conditions. By rational screening for mutations in bacterial ribosomal proteins or RNA polymerases, ribosome engineering is a versatile approach to obtain mutants with improved titers for microbial product formation or new natural products through activating silent

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Rosales Martínez, Antonio, Ignacio Rodríguez-García, and Josefa L. López-Martínez. "Divergent Strategy in Marine Tetracyclic Meroterpenoids Synthesis." Marine Drugs 19, no. 5 (2021): 273. http://dx.doi.org/10.3390/md19050273.

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The divergent total synthesis strategy can be successfully applied to the preparation of families of natural products using a common late-stage pluripotent intermediate. This approach is a powerful tool in organic synthesis as it offers opportunities for the efficient preparation of structurally related compounds. This article reviews the synthesis of the marine natural product aureol, as well as its use as a common intermediate in the divergent synthesis of other marine natural and non-natural tetracyclic meroterpenoids.

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Pereira, Ricardo F. S., and Carla C. C. R. de Carvalho. "Improving Bioprocess Conditions for the Production of Prodigiosin Using a Marine Serratia rubidaea Strain." Marine Drugs 22, no. 4 (2024): 142. http://dx.doi.org/10.3390/md22040142.

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The enormous potential attributed to prodigiosin regarding its applicability as a natural pigment and pharmaceutical agent justifies the development of sound bioprocesses for its production. Using a Serratia rubidaea strain isolated from a shallow-water hydrothermal vent, optimization of the growth medium composition was carried out. After medium development, the bacterium temperature, light and oxygen needs were studied, as was growth inhibition by product concentration. The implemented changes led to a 13-fold increase in prodigiosin production in a shake flask, reaching 19.7 mg/L. The condi

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Sun, Xueni, Yintao Zhang, Ying Zhou, et al. "NPCDR: natural product-based drug combination and its disease-specific molecular regulation." Nucleic Acids Research 50, no. D1 (2021): D1324—D1333. http://dx.doi.org/10.1093/nar/gkab913.

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Abstract Natural product (NP) has a long history in promoting modern drug discovery, which has derived or inspired a large number of currently prescribed drugs. Recently, the NPs have emerged as the ideal candidates to combine with other therapeutic strategies to deal with the persistent challenge of conventional therapy, and the molecular regulation mechanism underlying these combinations is crucial for the related communities. Thus, it is urgently demanded to comprehensively provide the disease-specific molecular regulation data for various NP-based drug combinations. However, no database ha

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Čanji-Panić, Jelena, Nemanja Todorović, Ana Stjepanović, and Mladena Lalić-Popović. "The potential of natural products use in fused deposition modeling 3D printing of pharmaceutical dosage forms." Arhiv za farmaciju 72, no. 6 (2022): 621–36. http://dx.doi.org/10.5937/arhfarm72-40155.

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In recent years, the interest in 3D printing of medicines has increased due to many advantages of this technology, such as flexibility of the dose and dosage form of the printed product. Fused deposition modeling (FDM) is one of the most popular 3D printing technologies in the pharmaceutical field, due to its low cost and simplicity. The subject of this review is the potential use of natural products as biodegradable and biocompatible materials with good safety profiles in FDM 3D printing of pharmaceuticals. Natural products such as alginate, chitosan and starch have already been employed as e

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Debnath, Pradip. "Recent Advances in the Hofmann Rearrangement and Its Application to Natural Product Synthesis." Current Organic Chemistry 23, no. 22 (2020): 2402–35. http://dx.doi.org/10.2174/1385272823666191021115508.

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: C-N bond formation reactions are the most important transformations in (bio)organic chemistry because of the widespread occurrence of amines in pharmaceuticals, natural products, and biologically active compounds. The Hofmann rearrangement is a well-known method used for the preparation of primary amines from amides. But, the traditional version of the Hofmann rearrangement often gave relatively poor yields due to over-oxidation or due to the poor solubility of some amides in aqueous base, and created an enormous amount of waste products. Developments over the last two decades, in particular

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Krings, Ulrich, and Ralf Guenter Berger. "Terpene Bioconversion – How does its Future Look?" Natural Product Communications 5, no. 9 (2010): 1934578X1000500. http://dx.doi.org/10.1177/1934578x1000500927.

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The usage of essential oils as such or of volatile fractions thereof is widespread in the flavor and fragrance industry to aromatize perfumery and cosmetic products, foodstuffs, and many household and pharmaceutical products. The increased market share of convenience food together with consumers’ request for constant high quality and natural products have established a lasting increase in the demand for natural flavorings that cannot be satisfied by the traditional plant materials. This review summarizes selected work on terpene bioconversion / transformation and focuses on recently published

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Chen, Xin, Joshua Drew, Wren Berney, and Wei Lei. "Neuroprotective Natural Products for Alzheimer’s Disease." Cells 10, no. 6 (2021): 1309. http://dx.doi.org/10.3390/cells10061309.

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Alzheimer’s disease (AD) is the number one neurovegetative disease, but its treatment options are relatively few and ineffective. In efforts to discover new strategies for AD therapy, natural products have aroused interest in the research community and in the pharmaceutical industry for their neuroprotective activity, targeting different pathological mechanisms associated with AD. A wide variety of natural products from different origins have been evaluated preclinically and clinically for their neuroprotective mechanisms in preventing and attenuating the multifactorial pathologies of AD. This

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Winand, Lea, Dustin Joshua Vollmann, Jacqueline Hentschel, and Markus Nett. "Characterization of a Solvent-Tolerant Amidohydrolase Involved in Natural Product Heterocycle Formation." Catalysts 11, no. 8 (2021): 892. http://dx.doi.org/10.3390/catal11080892.

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Heterocycles are important building blocks in pharmaceutical drugs and their enzymatic synthesis is attracting increasing interest. In recent years, various enzymes of the amidohydrolase superfamily were reported to catalyze heterocycle-forming condensation reactions. One of these enzymes, MxcM, is biochemically and kinetically characterized in this study. MxcM generates an imidazoline moiety in the biosynthesis of the natural product pseudochelin A, which features potent anti-inflammatory properties. The enzyme shows maximal activity at 50 °C and pH 10 as well as a kcat/Km value of 22,932 s−1

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Waldbauer, Katharina, Ruxandra McKinnon, and Brigitte Kopp. "Apple Pomace as Potential Source of Natural Active Compounds." Planta Medica 83, no. 12/13 (2017): 994–1010. http://dx.doi.org/10.1055/s-0043-111898.

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AbstractApple pomace is a waste product of the apple manufacturing industry that has been in the focus of life sciences as it represents a low-cost source of fruit-derived compounds. High fruit consumption is associated with beneficial health effects, and therefore, apple pomace and its constituents raise therapeutic interest. The present work reviews (i) the chemical constituents of apple pomace, (ii) optimized extraction methods of apple pomace compounds, and (iii) biological activities of apple pomace. Current evidence of apple pomace influence on digestion and metabolism, cholesterol and t

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Xiao, Hong-Xiu, Qing-Xiang Yan, Zhi-Hui He, et al. "Total Synthesis and Anti-Inflammatory Bioactivity of (−)-Majusculoic Acid and Its Derivatives." Marine Drugs 19, no. 6 (2021): 288. http://dx.doi.org/10.3390/md19060288.

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The first total synthesis of marine natural product, (−)-majusculoic acid (1) and its seven analogs (9–15), was accomplished in three to ten steps with a yield of 3% to 28%. The strategy featured the application of the conformational controlled establishment of the trans-cyclopropane and stereochemical controlled bromo-olefination or olefination by Horner–Wadsworth–Emmons (HWE) reaction. The potential anti-inflammatory activity of the eight compounds (1 and 9–15) was evaluated by determining the nitric oxide (NO) production in the lipopolysaccharide (LPS)-induced mouse macrophages RAW264.7. (−

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S. Sathya, Karthiga. D, Lokesh. S, Sabari Manikandan, and V. R. Rajeswari. "Natural Products with Artificial Intelligence: A Revolution in Drug Discovery." International Journal of Research in Pharmacy and Allied Science 04, no. 01 (2025): 45–62. https://doi.org/10.71431/ijrpas.2025.4105.

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Natural products have been instrumental in shaping modern medicine, offering a plethora of bioactive compounds used as pharmaceuticals. Despite their immense potential, the traditional approaches to natural product research are often labor-intensive and time-consuming. Artificial Intelligence (AI) has emerged as a transformative tool in this domain, enabling efficient analysis, prediction, and discovery of natural products. This manuscript explores the intersection of natural products and AI, detailing its applications in drug discovery, challenges, and future prospects. By integrating AI, res

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Bagameri, Lilla, Gabriela-Maria Baci, and Daniel Severus Dezmirean. "Royal Jelly as a Nutraceutical Natural Product with a Focus on Its Antibacterial Activity." Pharmaceutics 14, no. 6 (2022): 1142. http://dx.doi.org/10.3390/pharmaceutics14061142.

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Royal jelly (RJ) is one of the most valued natural products and is known for its health-promoting properties. Due to its therapeutic effects, it has been used in medicine since antiquity. Nowadays, several studies indicate that RJ acts as a powerful antimicrobial agent. Indeed, researchers shed light on its antioxidant and anticancer activity. RJ’s biological properties are related to its bioactive compounds, such as proteins, peptides, phenolic, and fatty acids. The aim of this review is to highlight recent findings on RJ’s main bioactive compounds correlated with its health-promoting propert

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López-Martínez, Josefa L., Irene Torres-García, Irene Moreno-Gutiérrez та ін. "A Concise Diastereoselective Total Synthesis of α-Ambrinol". Marine Drugs 21, № 4 (2023): 230. http://dx.doi.org/10.3390/md21040230.

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(-)-cis-α-Ambrinol is a natural product present in ambergris, a substance of marine origin that has been highly valued by perfumers. In this paper, we present a new approach to its total synthesis. The starting material is commercially available α-ionone and the key step is an intramolecular Barbier-type cyclization induced by CpTiCl2, an organometallic compound prepared in situ by a CpTiCl3 reduction with Mn.

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El-Chaar, Nader N., Thomas E. Smith, Gajendra Shrestha, et al. "Topsentinol L Trisulfate, a Marine Natural Product That Targets Basal-like and Claudin-Low Breast Cancers." Marine Drugs 19, no. 1 (2021): 41. http://dx.doi.org/10.3390/md19010041.

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Patients diagnosed with basal-like breast cancer suffer from poor prognosis and limited treatment options. There is an urgent need to identify new targets that can benefit patients with basal-like and claudin-low (BL-CL) breast cancers. We screened fractions from our Marine Invertebrate Compound Library (MICL) to identify compounds that specifically target BL-CL breast cancers. We identified a previously unreported trisulfated sterol, i.e., topsentinol L trisulfate (TLT), which exhibited increased efficacy against BL-CL breast cancers relative to luminal/HER2+ breast cancer. Biochemical invest

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Dev Prakash and Rishi Kumar. "A review on natural polymer locust bean gum." World Journal of Biology Pharmacy and Health Sciences 13, no. 1 (2023): 277–83. http://dx.doi.org/10.30574/wjbphs.2023.13.1.0031.

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Locust bean pods were utilized as cattle feed for a very long time but now its seed endosperm powder is utilized as locust bean gum in various industries such as food, cosmetic, pharmaceutical, textile, paint, mining, oil drilling and construction industries for its thickening and stabilizing properties. In pharmaceutical industries, locust bean gum is used in the production of solid monolithic matrix systems, films, beads, micro-particles, nano-particles, inhalable and injectable systems, as well as in viscous liquid and gel formulations. Locust bean gum is used as an additive in food industr

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Dev, Prakash, and Kumar Rishi. "A review on natural polymer locust bean gum." World Journal of Biology Pharmacy and Health Sciences 13, no. 1 (2023): 277–83. https://doi.org/10.5281/zenodo.7947785.

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Locust bean pods were utilized as cattle feed for a very long time but now its seed endosperm powder is utilized as locust bean gum in various industries such as food, cosmetic, pharmaceutical, textile, paint, mining, oil drilling and construction industries for its thickening and stabilizing properties. In pharmaceutical industries, locust bean gum is used in the production of solid monolithic matrix systems, films, beads, micro-particles, nano-particles, inhalable and injectable systems, as well as in viscous liquid and gel formulations. Locust bean gum is used as an additive in food industr

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García, José, Gianluigi Franci, Raquel Pereira, et al. "Epigenetic profiling of the antitumor natural product psammaplin A and its analogues." Bioorganic & Medicinal Chemistry 19, no. 12 (2011): 3637–49. http://dx.doi.org/10.1016/j.bmc.2010.12.026.

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Manyi-Loh, E. "Goldcrest honey and its solvent extracts: A natural product with anti-Helicobacter pylori activity." African Journal of Pharmacy and Pharmacology 7, no. 8 (2013): 431–38. http://dx.doi.org/10.5897/ajpp12.417.

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Suresh, Dittu, Shekh Sabir, Tsz Tin Yu, et al. "Natural Product Rottlerin Derivatives Targeting Quorum Sensing." Molecules 26, no. 12 (2021): 3745. http://dx.doi.org/10.3390/molecules26123745.

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Rottlerin is a natural product consisting of chalcone and flavonoid scaffolds, both of which have previously shown quorum sensing (QS) inhibition in various bacteria. Therefore, the unique rottlerin scaffold highlights great potential in inhibiting the QS system of Pseudomonas aeruginosa. Rottlerin analogues were synthesised by modifications at its chalcone- and methylene-bridged acetophenone moieties. The synthesis of analogues was achieved using an established five-step synthetic strategy for chalcone derivatives and utilising the Mannich reaction at C6 of the chromene to construct morpholin

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Bruni, Natascia, Elisa Martello, Valeria Gabriele, and Francesca Perondi. "Acid Suppressant Activity of Feed Dietary Supplements for Dogs." Journal of Pharmacy and Nutrition Sciences 13 (August 30, 2023): 38–44. http://dx.doi.org/10.29169/1927-5951.2023.13.04.

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Gastritis is a common finding in pets and acid suppression plays an important role in its management. Acid suppression is the most important component in the treatment of gastritis and prevention of its complications. There are many drugs commonly used in veterinary medicine but the use of natural feed supplements is increasing. The aim of this in vitro study is the comparison of four supplements based on a combination of antacid salts and natural products at two pH conditions (pH 2 and 4.5) and at five time points. In addition, we wanted to confirm the formation of the gel during the test. Al

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Hidayat, Irwan. "Branding Management of Sido Muncul Product (Case Study of TolakAngin) and Its Implications for The Indonesian Healthcare Industry." Jurnal Dinamika Manajemen 16, no. 1 (2025): 88–106. https://doi.org/10.15294/jdm.v16i1.16692.

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This study aims to analyze the management branding of Sido Muncul products, especially the Tolak Angin product, in relation to the broader pharmaceutical industry in Indonesia. This research utilizes a systematic literature review (SLR) as a qualitative approach, supported by tools such as Publish or Perish, PRISMA, and Covidence softwareto collect, filter, and evaluate relevant academic sources. Additionally, a science mapping review serves as the quantitative approach, using Mendeley and VOSviewer software to visualize bibliometric data and research trends. Tolak Angin exemplifies effective

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Nair, Anagha, Ankesh Ahirwar, Shashikala Singh, et al. "Astaxanthin as a King of Ketocarotenoids: Structure, Synthesis, Accumulation, Bioavailability and Antioxidant Properties." Marine Drugs 21, no. 3 (2023): 176. http://dx.doi.org/10.3390/md21030176.

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Astaxanthin (3,3-dihydroxy-β, β-carotene-4,4-dione) is a ketocarotenoid synthesized by Haematococcus pluvialis/lacustris, Chromochloris zofingiensis, Chlorococcum, Bracteacoccus aggregatus, Coelastrella rubescence, Phaffia rhodozyma, some bacteria (Paracoccus carotinifaciens), yeasts, and lobsters, among others However, it is majorly synthesized by Haematococcus lacustris alone (about 4%). The richness of natural astaxanthin over synthetic astaxanthin has drawn the attention of industrialists to cultivate and extract it via two stage cultivation process. However, the cultivation in photobiorea

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Wang, Zhi-Fan, Yu-Lin You, Fei-Fei Li, Wen-Ru Kong, and Shu-Qi Wang. "Research Progress of NMR in Natural Product Quantification." Molecules 26, no. 20 (2021): 6308. http://dx.doi.org/10.3390/molecules26206308.

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In the fields of medicine and health, traditional high-performance liquid chromatography or UV-visible spectrophotometry is generally used for substance quantification. However, over time, nuclear magnetic resonance spectroscopy (NMR) has gradually become more mature. Nuclear magnetic resonance spectroscopy has certain advantages in the quantitative analysis of substances, such as being nondestructive, having a high flux and short analysis time. Nuclear magnetic resonance spectroscopy has been included in the pharmacopoeiae of various countries. In this paper, the principle of nuclear magnetic

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Flavius, Phrangsngi Nonglang, Roy Dhritiman, Newar Divya, and Bhan Surya. "Tangeretin-a special polymethoxyflavones: An insight into its pharmacological and therapeutic effects on diabetes." GSC Biological and Pharmaceutical Sciences 23, no. 1 (2023): 127–36. https://doi.org/10.5281/zenodo.7925034.

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With global diabetes complication growing rapidly at an alarming rate each year, there is an increasing need to find suitable therapeutics for its management, regulation, and treatment which is cost-effective, safe, and naturally available. Continued dependence only on the available synthetic drug is not a solution. Therefore, there is a need to find suitable natural adjuncts to help manage diabetes. Flavonoids are a class of compounds that have been utilized for therapeutic purposes for generations due to their wide and varied pharmacological properties. One such important naturally available

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Fang, Tian, Xiaoqian Zhang, Shanshan Hu, Yanyan Yu, Xue Sun, and Nianjun Xu. "Enzymatic Degradation of Gracilariopsis lemaneiformis Polysaccharide and the Antioxidant Activity of Its Degradation Products." Marine Drugs 19, no. 5 (2021): 270. http://dx.doi.org/10.3390/md19050270.

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Gracilariopsis lemaneiformis polysaccharides (GLP) were degraded using pectinase, glucoamylase, cellulase, xylanase, and β-dextranase into low-molecular-weight polysaccharides, namely, GPP, GGP, GCP, GXP, and GDP, respectively, and their antioxidant capacities were investigated. The degraded GLP showed higher antioxidant activities than natural GLP, and GDP exhibited the highest antioxidant activity. After the optimization of degradation conditions through single-factor and orthogonal optimization experiments, four polysaccharide fractions (GDP1, GDP2, GDP3, and GDP4) with high antioxidant abi

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Alex, Raveena Ann, Joel Augustine, Ashish Nair, and Jayanthi Abraham. "Bioconversion of isoeugenol to vanillin by bacillus firmus strain JAA1." Research Journal of Biotechnology 17, no. 12 (2022): 61–65. http://dx.doi.org/10.25303/1712rjbt61065.

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Natural aromatic compounds are in growing demand in the food and pharmaceutical market. Due to limited sources for natural aroma compounds, there is an increasing interest in developing different sources for vanillin and another aromatic aldehydes. Some microbial species have been reported to produce aromatic aldehyde as an intermediate product in the degradation pathway of phenylpropanoids. The present work was carried out to isolate microbial species, capable of transforming isoeugenol to vanillin and its metabolites. Bacillus firmus strain JAA1 isolated from soil sample was found to transfo

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Leão, Tiago, Mingxun Wang, Nathan Moss, et al. "A Multi-Omics Characterization of the Natural Product Potential of Tropical Filamentous Marine Cyanobacteria." Marine Drugs 19, no. 1 (2021): 20. http://dx.doi.org/10.3390/md19010020.

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Microbial natural products are important for the understanding of microbial interactions, chemical defense and communication, and have also served as an inspirational source for numerous pharmaceutical drugs. Tropical marine cyanobacteria have been highlighted as a great source of new natural products, however, few reports have appeared wherein a multi-omics approach has been used to study their natural products potential (i.e., reports are often focused on an individual natural product and its biosynthesis). This study focuses on describing the natural product genetic potential as well as the

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Addae-Mensah, Ivan, Esther Njonge, and Gichuru Muriuki. "9-Methoxychelerythrine as a True Natural Product. Its Antimicrobial Activity and Cardiovascular Effects." Planta Medica 54, no. 06 (1988): 561. http://dx.doi.org/10.1055/s-2006-962558.

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Sakshi S. Raut, Sakshi S. Raut, Sumit Nerkar Sumit Nerkar, and Bhavana P. Raut Bhavana P. Raut. "The Science of Flaxseed in Skincare: A Review on Its Moisturizing and Hydrating Benefits." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 1–8. https://doi.org/10.35629/4494-10030108.

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As a fibre crop people know flaxseed because it delivers important nutrients such as phytoestrogens in the form of lignans alongside omega-3 fats, PUFA along with ALA. The natural ingredient has developed into multiple industrial applications because it now serves many functions throughout haircare, skincare, pharmaceuticals, health items and cosmetics. Flaxseed demonstrates extensive commercial value through its bioactive compounds and nutritional aspects which establishes it as an essential all-purpose agricultural product. The natural gelling qualities of flaxseed mucilage provide pharmaceu

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De-Eknamkul, Wanchai. "Research work of Prof. De-Eknamkul, including the mechanistic synergy of hair growth promotion by the Avicennia marina extract and its active constituent (avicequinone C) in dermal papilla cells isolated from androgenic alopecia patients." Impact 2024, no. 2 (2024): 66–68. http://dx.doi.org/10.21820/23987073.2024.2.66.

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Androgenetic alopecia (AGA) is a genetically-predetermined disorder that affects many people around the world, leading to progressive hair loss. This baldness can negatively impact people’s perceptions of themselves and scientists are searching for a cure. There are only two US Food and Drug Administration-approved drugs used to treat AGA and they both have side effects. If a natural anti-AGA product could be developed with the ability to be effective minus negative side effects, this could be a game-changer for people with AGA. Professor Wanchai De-Eknamkul, Department of Pharmacognosy and Ph

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Bergamo, Alberta, and Gianni Sava. "Lysozyme: A Natural Product with Multiple and Useful Antiviral Properties." Molecules 29, no. 3 (2024): 652. http://dx.doi.org/10.3390/molecules29030652.

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Lysozyme, especially the one obtained from hen’s egg white, continues to show new pharmacological properties. The fact that only a few of these properties can be translated into therapeutic applications is due to the lack of suitable clinical studies. However, this lack cannot hide the evidence that is emerging from scientific research. This review for the first time examines, from a pharmacological point of view, all the relevant studies on the antiviral properties of lysozyme, analyzing its possible mechanism of action and its ability to block viral infections and, in some cases, inhibit vir

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Herrmann, Jennifer. "Search for hits and early leads from soil bacteria to combat infectious diseases." Journal of Infection in Developing Countries 12, no. 02.1 (2018): 24S. http://dx.doi.org/10.3855/jidc.10096.

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Introduction: Natural products are the source of a large fraction of the current pharmaceutics available against human disease. However, the discovery of novel compounds with new mechanisms of action is becoming increasingly challenging. We focused our work on soil-dwelling Myxobacteria from highly diverse samples, which are more and more recognized as an important natural product source. Methodology: Our discovery pipeline combines traditional whole cell-based activity screens with state-of-the-art analytical techniques and a comprehensive dereplication process. Having identified an ant

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Zarena, Arasali S. "Exploring the Potential Bioactive Properties of Marine Natural Products." Current Bioactive Compounds 15, no. 5 (2019): 524–39. http://dx.doi.org/10.2174/1573407214666180727092555.

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Background: The marine world is highly diversified and is of great importance for its sustainable utilization as resources for human life. Although marine resource economy has its own share in the international market, there is only a handful of research occurring, the probability of not being completely explored. It has now become virtually possible to characterize the metabolites by bioanalytical techniques and molecular biology methodology. The marine biomes harbour largely diatoms, bacteria, fungi, actinomycetes, and cyanobacteria that are harnessed for their rich structurally diverse seco

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Fuwa, Haruhiko. "Synthesis-Driven Stereochemical Assignment of Marine Polycyclic Ether Natural Products." Marine Drugs 19, no. 5 (2021): 257. http://dx.doi.org/10.3390/md19050257.

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Marine polycyclic ether natural products have gained significant interest from the chemical community due to their impressively huge molecular architecture and diverse biological functions. The structure assignment of this class of extraordinarily complex natural products has mainly relied on NMR spectroscopic analysis. However, NMR spectroscopic analysis has its own limitations, including configurational assignment of stereogenic centers within conformationally flexible systems. Chemical shift deviation analysis of synthetic model compounds is a reliable means to assign the relative configura

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De Rop, Anne-Sofie, Jeltien Rombaut, Thomas Willems, et al. "Novel Alkaloids from Marine Actinobacteria: Discovery and Characterization." Marine Drugs 20, no. 1 (2021): 6. http://dx.doi.org/10.3390/md20010006.

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The marine environment is an excellent resource for natural products with therapeutic potential. Its microbial inhabitants, often associated with other marine organisms, are specialized in the synthesis of bioactive secondary metabolites. Similar to their terrestrial counterparts, marine Actinobacteria are a prevalent source of these natural products. Here, we discuss 77 newly discovered alkaloids produced by such marine Actinobacteria between 2017 and mid-2021, as well as the strategies employed in their elucidation. While 12 different classes of alkaloids were unraveled, indoles, diketopiper

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Roufogalis, Basil D., Arthur D. Conigrave, and Emanuel E. Strehler. "INTRODUCTION - Mechanism-based Development of Natural Products for Human Health." Journal of Pharmacy & Pharmaceutical Sciences 16, no. 2 (2013): 123. http://dx.doi.org/10.18433/j3d02f.

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This Special Issue of the Journal of Pharmacy and Pharmaceutical Sciences arises from an inaugural conference on “Mechanism-Based Natural Product Development” held at Whistler Mountain, Canada on September 21-22, 2012. The aim of the conference was to bring together scientists from various disciplines to discuss the development of new therapeutic products from natural medicines based on mechanistic and related scientific studies. It provided an opportunity to explore new directions in natural medicine research and development, with the ultimate objective of leading to greater integration

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H. Silva, Thamyres, Joana Mesquita-Guimarães, Bruno Henriques, Filipe S. Silva, and Márcio C. Fredel. "The Potential Use of Oyster Shell Waste in New Value-Added By-Product." Resources 8, no. 1 (2019): 13. http://dx.doi.org/10.3390/resources8010013.

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Calcium carbonate is one of the most used raw materials in various industries, such as construction materials, food supplement, pharmaceutics, animal feed, plastic production, and others. Calcium carbonate can derive from marine wastes, like crustaceans and bivalve’s shells. The worldwide demand for new sources of food has increased exponentially, and following that tendency, the mariculture—especially the oyster culture—has been increasingly resorting to farming techniques. In 2016, 438 billion tons of oysters were produced. The majority of the shells were unduly discarded, presenting a publi

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Caudal, Flore, Nathalie Tapissier-Bontemps, and Ru Angelie Edrada-Ebel. "Impact of Co-Culture on the Metabolism of Marine Microorganisms." Marine Drugs 20, no. 2 (2022): 153. http://dx.doi.org/10.3390/md20020153.

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Natural products from plants have been listed for hundreds of years as a source of biologically active molecules. In recent years, the marine environment has demonstrated its ability to provide new structural entities. More than 70% of our planet’s surface is covered by oceans, and with the technical advances in diving and remotely operated vehicles, it is becoming easier to collect samples. Although the risk of rediscovery is significant, the discovery of silent gene clusters and innovative analytical techniques has renewed interest in natural product research. Different strategies have been

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Mayer, Alejandro M. S., Aimee J. Guerrero, Abimael D. Rodríguez, Orazio Taglialatela-Scafati, Fumiaki Nakamura, and Nobuhiro Fusetani. "Marine Pharmacology in 2016–2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action." Marine Drugs 19, no. 2 (2021): 49. http://dx.doi.org/10.3390/md19020049.

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The review of the 2016–2017 marine pharmacology literature was prepared in a manner similar as the 10 prior reviews of this series. Preclinical marine pharmacology research during 2016–2017 assessed 313 marine compounds with novel pharmacology reported by a growing number of investigators from 54 countries. The peer-reviewed literature reported antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities for 123 marine natural products, 111 marine compounds with antidiabetic and anti-inflammatory activities as well as affecting the immune and nervous system, while in co

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MARȚIȘ (PETRUȚ), Georgiana, Sevastița MUSTE, Andruța MUREȘAN, et al. "GELLED CONFECTIONERY PRODUCT SUPPLEMENTED WITH GUARANA (PAULLINIA CUPANA KUNTH) POWDER. DEVELOPMENT AND CHARACTERIZATION." Hop and Medicinal Plants 28, no. 1-2 (2020): 202–10. https://doi.org/10.15835/hpm.v28i1-2.13999.

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The main components of Paullinia cupana Kunth which are relevant for food and pharmaceutical industry are procyanidin, caffeic acid and its derivatives. Hence, the enrichment the most consumed foods matrix with phenolic compounds with antioxidant activity revealed by natural plants extract, is a clear and precise way to provide bioactive compounds to consumers. Admitting the fact that food can also be a vehicle that transports substances with a bioactive role in the human body, confectionery products, more precisely a gelled confectionery product, fit perfectly, due to consumption at all ages.

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Haney, Kendra M., Feng Zhang, Christopher K. Arnatt, et al. "The natural product CCR5 antagonist anibamine and its analogs as anti-prostate cancer agents." Bioorganic & Medicinal Chemistry Letters 21, no. 18 (2011): 5159–63. http://dx.doi.org/10.1016/j.bmcl.2011.07.058.

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Zaman, Shariq M., and Marjorie A. Jones. "Potent Inhibitory Activity of Natural Product Anaephene B and Analogues against Leishmania tarentolae In Vitro." Molecules 28, no. 3 (2023): 946. http://dx.doi.org/10.3390/molecules28030946.

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In this study, a specific alkylphenol natural product, anaephene B, and its unique synthesized derivatives were tested for their inhibitory effect on the protozoan parasite Leishmania tarentolae. In a series of cell viability tests and enzyme assays, these test compounds have produced interesting results with regard to their antibiotic effect, showing similar potency against L. tarentolae as they do against drug-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). All compounds tested in this study have shown the ability to completely inhibit our model system, L. tare

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Wang, Huan, Dusan Hesek, Mijoon Lee, et al. "The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity." Journal of Natural Products 79, no. 4 (2016): 1219–22. http://dx.doi.org/10.1021/acs.jnatprod.6b00057.

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Najmi, Asim, Sadique A. Javed, Mohammed Al Bratty, and Hassan A. Alhazmi. "Modern Approaches in the Discovery and Development of Plant-Based Natural Products and Their Analogues as Potential Therapeutic Agents." Molecules 27, no. 2 (2022): 349. http://dx.doi.org/10.3390/molecules27020349.

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Natural products represents an important source of new lead compounds in drug discovery research. Several drugs currently used as therapeutic agents have been developed from natural sources; plant sources are specifically important. In the past few decades, pharmaceutical companies demonstrated insignificant attention towards natural product drug discovery, mainly due to its intrinsic complexity. Recently, technological advancements greatly helped to address the challenges and resulted in the revived scientific interest in drug discovery from natural sources. This review provides a comprehensi

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Gupta, Dr Seema. "Gond Katira, A Natural Coolant: An Overview." International Journal for Research in Applied Science and Engineering Technology 13, no. 7 (2025): 31–34. https://doi.org/10.22214/ijraset.2025.72922.

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Gond Katira is obtained from the discharge of Astragalus species. This is also known as Tragacanth gum, which has hydrophilic properties and is considered as natural coolant. Astragalus is a dicotyledonous plant and belongs to the Fabaceae family. Its important species are A. gummifer, A. brachycalyx, A. myriacanthus, A. kurdicus and A. echidna. This natural hydrocolloid after absorption of water swells to form a mucilaginous gel and helps to retain water and body temperature in summers. Tragacanth gum is made of tragacanthin and bassorin, which has anti-inflammatory, immunological, antioxidan

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Chen, Ru, Weili Wang, Ronghua Yin, et al. "Structural Characterization and Anticoagulant Activities of a Keratan Sulfate-like Polysaccharide from the Sea Cucumber Holothuria fuscopunctata." Marine Drugs 21, no. 12 (2023): 632. http://dx.doi.org/10.3390/md21120632.

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A sulfated polysaccharide (AG) was extracted and isolated from the sea cucumber H. fuscopunctata, consisting of GlcNAc, GalNAc, Gal, Fuc and lacking any uronic acid residues. Importantly, several chemical depolymerization methods were used to elucidate the structure of the AG through a bottom-up strategy. A highly sulfated galactose (oAG-1) and two disaccharides labeled with 2,5-anhydro-D-mannose (oAG-2, oAG-3) were obtained from the deaminative depolymerized product along with the structures of the disaccharide derivatives (oAG-4~oAG-6) identified from the free radical depolymerized product,

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