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Journal articles on the topic 'ITU-T G.65x'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Torbus, Sławomir Andrzej, and Jacek Andrzej Michalski. "Testing of a Polarimetric Current Sensor in the Frequency Domain." Sensors 21, no. 9 (2021): 3008. http://dx.doi.org/10.3390/s21093008.

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This paper proposes an original model of a polarimetric current sensor, in which the measuring coil was made of a single mode telecommunication optical fiber ITU-T G.652, G.653, G.655, and G.657. This sensor was subjected to the commercialization process, which was carried out by a company combining the functionality of a technology transfer center with the capabilities of the Startit Fund Sp. z o.o. The published results included the analysis of the implementation readiness, the analysis of the market potential, the valuation of the industrial property rights of the invention and indicated fu

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2

Ferrari, Alessio, Antonio Napoli, Johannes K. Fischer, et al. "Assessment on the Achievable Throughput of Multi-Band ITU-T G.652.D Fiber Transmission Systems." Journal of Lightwave Technology 38, no. 16 (2020): 4279–91. http://dx.doi.org/10.1109/jlt.2020.2989620.

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3

Ruiz, Milton, and Esteban Inga. "Despliegue óptimo de redes ópticas para comunicaciones en redes eléctricas inteligentes." I+D Tecnológico 15, no. 2 (2019): 79–85. http://dx.doi.org/10.33412/idt.v15.2.2249.

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El presente artículo muestra el diseño óptimo de la red óptica de comunicaciones en redes eléctricas inteligentes. Para analizar el problema de cobertura se define cada una de las subestaciones con sus respectivas coordenadas georreferenciadas, por medio del algoritmo planteado es posible crear el árbol de mínima expansión que comunica a todos los actores del sector eléctrico. Se toma en cuenta una serie de restricciones, tales como rendimiento de cada etapa en términos de requisitos de tasa de bits de datos, potencia, tasa de bits errados (Bit Error Rate) y jitter. El objetivo es limitar las

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Jiménez, María Soledad, and Jorge Gabriel Cadena Paredes. "Análisis y Simulación del Fenómeno de Dispersión Por Modo De Polarización (PMD) en Fibras Ópticas ITU-T G.655." Revista Politécnica 43, no. 2 (2019): 21–28. http://dx.doi.org/10.33333/rp.vol43n2.936.

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Este trabajo se centra en el análisis y simulación del fenómeno de dispersión por modo de polarización (PMD) en fibras ópticas monomodo, abordándose los conceptos fundamentales y expresiones matemáticas que caracterizan a este tipo de dispersión que afecta a las comunicaciones por fibra hoy en día, especialmente al trabajar con velocidades de transmisión superiores a 10 Gbps y en largas distancias. Específicamente se analiza el nivel de dispersión y atenuación causados por la PMD en fibras de dispersión desplazada no nula NZDSF, de acuerdo al estándar ITU-T G.655, al transmitirse pulsos óptico

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5

Kumar, Dinesh, Puja Tiwary, Jaya Chakravarty, and Shyam Sundar. "Association of Interleukin-18 Gene Polymorphism with Susceptibility to Visceral Leishmaniasis in Endemic Area of Bihar, an Indian Population." Scientific World Journal 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/852104.

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Interleukin-18 (IL-18) is a cytokine that mediates Th1 response by inducing interferon-gamma (IFN-γ) production in T cells and natural killer cells. Genetic polymorphisms in the IL-18 gene have been found to be associated with its expression in cancer, tuberculosis, HBV infection, and various other diseases. Lower plasma level of IL-18 in visceral leishmaniasis (VL) patients might be associated with polymorphisms in the regulating or coding region of the gene. Three single nucleotide polymorphisms (SNPs), rs1946519 (−656 G/T) and rs187238 (−137 G/C) in the promoter region and rs549908 (+105 A/

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6

Cunnick, J. M., D. Hurt, B. Oppert, K. Sakamoto та D. J. Takemoto. "Binding of the γ-subunit of retinal rod-outer-segment phosphodiesterase with both transducin and the catalytic subunits of phosphodiesterase". Biochemical Journal 271, № 3 (1990): 721–27. http://dx.doi.org/10.1042/bj2710721.

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The gamma-subunit of retinal rod-outer-segment phosphodiesterase (PDE-gamma) is a multifunctional protein which interacts directly with both of the catalytic subunits of PDE (PDE alpha/beta) and the alpha-subunit of the retinal G (guanine-nucleotide-binding)-protein transducin alpha (T alpha). We have previously reported that the PDE gamma binds to T alpha at residue nos. 24-45 [Morrison. Rider & Takemoto (1987) FEBS Lett. 222, 266-270]. In vitro this results in inhibition of T alpha GTP/GDP exchange [Morrison, Cunnick, Oppert & Takemoto (1989) J. Biol. Chem. 264, 11671-11681]. We now

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Baba, Masanori, Katsunori Takashima, Hiroshi Miyake, et al. "TAK-652 Inhibits CCR5-Mediated Human Immunodeficiency Virus Type 1 Infection In Vitro and Has Favorable Pharmacokinetics in Humans." Antimicrobial Agents and Chemotherapy 49, no. 11 (2005): 4584–91. http://dx.doi.org/10.1128/aac.49.11.4584-4591.2005.

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ABSTRACT The first small-molecule CCR5 antagonist, TAK-779, could not be developed as an anti-human immunodeficiency virus type (anti-HIV-1) agent because of its poor oral bioavailability. TAK-652 is an orally bioavailable TAK-779 derivative with potent anti-HIV-1 activity. TAK-652 inhibited the binding of RANTES (regulated on activation, normal T-cell expressed and secreted), macrophage inflammatory protein 1α (MIP-1α), and MIP-1β to CCR5-expressing cells at nanomolar concentrations. TAK-652 could also suppress the binding of monocyte chemotactic protein 1 (MCP-1) to CCR2b-expressing cells. H

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Jerzak, Wojciech, and Monika Kuźnia. "Speciation of inorganic gaseous species and condensed phases during coconut husk combustion based on thermodynamic equilibrium calculations." E3S Web of Conferences 137 (2019): 01009. http://dx.doi.org/10.1051/e3sconf/201913701009.

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Thermodynamic equilibrium calculations to predict coconut husks (CH) combustion products have been carried out in this work. The selected type of biomass belongs to problematic fuels due to the fibrous structure preventing its grinding, and high chlorine content. The calculations results showed, that the combustion temperature for the tested range of 600-1000°C clearly affects the concentrations of chlorine species in the flue gas. When the temperature was below 820°C, the highest concentration had HCl(g), and above 820°C KCl(g). The chlorine was also present in ash, as KCl-NaCl-RbCl solid sol

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Smetanina, O. V., I. I. Ibatulin, V. S. Bomko, L. G. Bomko та O. A. Kuzmenko. "Вплив змішанолігандного комплексу кобальту на його обмін у організмі високопродуктивних корів". Ukrainian Journal of Ecology 7, № 4 (2017): 559–63. http://dx.doi.org/10.15421/2017_160.

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<p>In the scientific and economic research we investigated the influence different levels of mixed ligand complex of Cobalt on milk productivity and its exchange in the organism of highly productive cows of Ukrainian Black-and-White milk breed in combination with sulfates: Zinc 650 g/t, potassium 38 g/t, sodium selenite 1.8 g/t. For cows of the 1st control group, we administrated 8.9 g/t of cobalt sulfate, 2nd group – 9.7 g/t of mixed ligand complex of cobalt, 3rd, 4th and 5th experimental groups respectively, were fed into rations, g/t: 7.3; 4.9, and 2.4. As a result, the cows of the 1s

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Wójcik, Grzegorz Michał. "Optimization of silica glass capillary and rods drawing process." Photonics Letters of Poland 11, no. 1 (2019): 19. http://dx.doi.org/10.4302/plp.v11i1.891.

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Diameter fluctuations of silica glass rods and capillaries, during drawing process have been studied. We investigated an influence of drawing conditions on the quality of capillaries and rods. We fabricated two preforms made from different quality material. Fabricated preforms were used to draw microstructured fibers. Full Text: PDF ReferencesS. Habib et al., "Broadband dispersion compensation of conventional single mode fibers using microstructure optical fibers", Int. J. Lig. Opt. 124, 3851-3855 (2013) CrossRef A. Ziolowicz et al. "Overcoming the capacity crunch: ITU-T G.657.B3 compatible 7-

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Rossi, Davide, Silvia Rasi, Silvia Franceschetti, et al. "The Pharmacogenetic Background of the Host Is An Independent Predictor of Outcome and Toxicity in Diffuse Large B Cell Lymphoma Treated with R-CHOP21." Blood 112, no. 11 (2008): 480. http://dx.doi.org/10.1182/blood.v112.11.480.480.

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Abstract Scant information is available on the impact of the host genetic background as a predictor of outcome and toxicity in diffuse large B cell lymphoma (DLBCL) treated with R-CHOP. We verified whether relevant single nucleotide polymorphisms (SNPs) of the host may further refine prognostic stratification and toxicity prediction in DLBCL treated with R-CHOP21. The study was based on 106 consecutive DLBCL provided with a prospectively collected dataset. Candidate SNPs belonged to genes known to be involved in the pharmacogenetics of cyclophosphamide, doxorubicin, vincristine, prednisone and

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Newton-Tanzer, Emily, Hans Demmelmair, Jeannie Horak, Lesca Holdt, Berthold Koletzko, and Veit Grote. "Acute Metabolic Response in Adults to Toddler Milk Formulas with Alternating Higher and Lower Protein and Fat Contents, a Randomized Cross-Over Trial." Nutrients 13, no. 9 (2021): 3022. http://dx.doi.org/10.3390/nu13093022.

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Protein intake in early life influences metabolism, weight gain, and later obesity risk. As such, a better understanding of the effects of protein intake on the postprandial metabolism and its dynamics over time may elucidate underlying mechanisms. In a randomized crossover study, we observed fasted adults who consumed two isocaloric toddler milk formulas concentrated as meals of 480 kcal with 67 g of carbohydrates 30 g (HP) or 7 g (LP) protein, and 10 g or 20 g fat, respectively. Anthropometry and body plethysmography were assessed, and blood samples collected at baseline and over five hours.

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Dlamini, P. P., G. M. Isoe, D. Kiboi Boiyo, A. W. R. Leitch, and T. B. Gibbon. "All-Optical VCSEL-to-VCSEL Injection Based on Cross Gain Modulation for Routing in Multinode Flexible Spectrum Optimization in Optical Fibre Transmission Links." International Journal of Optics 2019 (August 4, 2019): 1–11. http://dx.doi.org/10.1155/2019/2987652.

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In this paper, we experimentally present a novel, all-optical spectral efficient vertical-cavity surface-emitting laser- (VCSEL-) based technique for routing and spectrum assignment in optical networks. Exploiting all optical VCSEL-to-VCSEL injection to attain cross gain modulation, the optical transmitter is optimized for optical transmission paths to assure quality of service by overcoming blockage for differentiated bandwidth demands during network congestion incidences. A 10 Gbps directly modulated 1549 nm master VCSEL is optically injected into the 1549 nm side modes of a 1550 nm slave VC

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Islam, MS, M. Zakaria, MM Hossain, MAB Mia, and AJMS Karim. "Effect of potassium on yield, quality and shelf life of tomato." Bangladesh Journal of Agricultural Research 44, no. 4 (2020): 659–68. http://dx.doi.org/10.3329/bjar.v44i4.45725.

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The experiment was conducted at the experimental field of the Department of Horticulture, Bangabandhu Sheikh Mujibur Rahman Agricultural University (BSMRAU), Salna, Gazipur, to study the effect of potassium on yield, quality and shelf life of tomato under ambient condition during 15 October 2015 to 30 June 2016. Six levels of K viz., 0, 35, 70, 105, 140 and 175 kg/ha consisted of the treatments of the experiment. The tomato plant treated with K105 produced maximum plant height (128.50 cm), number of fruits plant-1 (26.49), fruit diameter (5.71 cm), fruit length (5.83 cm), weight of fruits plan

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15

Cortes, J. E., E. J. Feldman, D. Douer, A. Raza, and S. Fruchtman. "Phase I evaluation of tipifarnib in combination with low-dose Ara-C (LDAC) in high-risk myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML): Interim results." Journal of Clinical Oncology 25, no. 18_suppl (2007): 14014. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.14014.

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14014 Background: Tipifarnib (T) is a farnesyltransferase inhibitor with clinical activity in MDS and AML. LDAC has utility in the elderly with MDS/AML; hence its use in combination with the investigational agent T to improve outcomes is warranted. Methods: The primary objective of this ongoing phase I, dose finding, multicenter, open-label study was to determine the maximum tolerated dose (MTD) based on dose limiting toxicities (DLT) of T+LDAC observed during the first 28 day cycle. MDS (IPSS Int 1, 2 or High) and untreated AML pts (age =75y or =65y with preceding MDS) or relapsed/refractory

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Holgado, Marina, and David Alique. "Preliminary Equipment Design for On-Board Hydrogen Production by Steam Reforming in Palladium Membrane Reactors." ChemEngineering 3, no. 1 (2019): 6. http://dx.doi.org/10.3390/chemengineering3010006.

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Hydrogen, as an energy carrier, can take the main role in the transition to a new energy model based on renewable sources. However, its application in the transport sector is limited by its difficult storage and the lack of infrastructure for its distribution. On-board H2 production is proposed as a possible solution to these problems, especially in the case of considering renewable feedstocks such as bio-ethanol or bio-methane. This work addresses a first approach for analyzing the viability of these alternatives by using Pd-membrane reactors in polymer electrolyte membrane fuel cell (PEM-FC)

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Majerová, M., R. Klement, A. Prnová, J. Kraxner, E. Bruneel, and D. Galusek. "Crystallization and visible–near-infrared luminescence of Bi-doped gehlenite glass." Royal Society Open Science 5, no. 12 (2018): 181667. http://dx.doi.org/10.1098/rsos.181667.

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Gehlenite glass microspheres, doped with a different concentration of Bi 3+ ions (0.5, 1, 3 mol%), were prepared by a combination of solid-state reaction followed by flame synthesis. The prepared glass microspheres were characterized from the point of view of surface morphology, phase composition, thermal and photoluminescence (PL) properties by optical and scanning electron microscopy (SEM), X-ray diffraction (XRD), differential scanning calorimetry (DSC) and PL spectroscopy. The closer inspection of glass microsphere surface by SEM confirmed a smooth surface. This was further verified by XRD

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Меkhtiyev, А. D., E. G. Neshina, P. Sh Madi, and D. A. Gorokhov. "Automated Fiber-Optic System for Monitoring the Stability of the Pit Quarry Mass and Dumps." Occupational Safety in Industry, no. 4 (April 2021): 19–26. http://dx.doi.org/10.24000/0409-2961-2021-4-19-26.

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This article ls with the issues related to the development of a system for monitoring the deformation and displacement of the rock mass leading to the collapse of the quarry sides. Monitoring system uses point-to-point fiber-optic sensors. Fiber-optic sensors and control cables of the communication line are made based on the single mode optical fibers, which allows to measure with high accuracy the deformations and displacements of the rock mass at a distance of 30-50 km. To create fiber-optic pressure sensors, an optical fiber of the ITU-T G. 652.D standard is used. Laboratory sample is devel

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de Melo Carvalho, M. T., A. de Holanda Nunes Maia, B. E. Madari, et al. "Biochar increases plant available water in a sandy soil under an aerobic rice cropping system." Solid Earth Discussions 6, no. 1 (2014): 887–917. http://dx.doi.org/10.5194/sed-6-887-2014.

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Abstract. The main objective of this study was to assess the impact of biochar rate (0, 8, 16 and 32 t ha−1) on the water retention capacity (WRC) of a sandy Dystric Plinthosol. The applied biochar was a by-product of slow pyrolysis (∼450 °C) of eucalyptus wood, milled to pass through a 2000 μm sieve that resulted in a material with an intrinsic porosity ≤10 μm and a specific surface area of ∼3.2 m2 g−1. The biochar was incorporated into the top 15 cm of the soil under an aerobic rice system. Our study focused on both the effects on WRC and rice yields at 2 and 3 years after application. Undis

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ROSTIANA, OTIH, WAWAN HARYUDIN, and ROSITA SMD SMD. "STABILITAS HASIL LIMA NOMOR HARAPAN KENCUR." Jurnal Penelitian Tanaman Industri 12, no. 4 (2020): 140. http://dx.doi.org/10.21082/jlittri.v12n4.2006.140-145.

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ABSTRAK<br />Tujuan pemuliaan kencur diarahkan untuk meningkatkan produksi<br />rimpang dan kandungan mutu utama yang sesuai dengan standar yang<br />ditetapkan oleh Materia Medika Indonesia, dalam upaya meningkatkan<br />pendapatan usahatani. Hasil seleksi berdasarkan produksi dan mutu<br />rimpang terhadap aksesi plasma nutfah yang terkumpul, terpilih 5 nomor<br />dengan rata-rata produksi rimpang &gt; 40 g/rumpun dan kadar minyak atsiri<br />&gt; 1,5%, yaitu V1, V2, V3, V4 dan V5. Kelima nomor diuji multilokasi di 5<br />lokasi pada 2

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Gataullin, B. I., R. Sh Khasanov, A. A. Savelyev, and I. G. Gataullin. "GENDER SPECIFICITY OF COLORECTAL CANCER IN THE REPUBLIC OF TATARSTAN." Siberian journal of oncology 20, no. 1 (2021): 16–23. http://dx.doi.org/10.21294/1814-4861-2021-20-1-16-23.

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The purpose of the study: to develop an expert system based on the construction of a «decision tree» for predicting the 5-year survival rate of patients with colorectal cancer.Material and Methods. T he study included 654 patients with colorectal cancer (CRC) who were treated from 2013 to 2015, including 434 men and 220 women. The average age of patients was 64,1 ± 10,2 years. All patients underwent genetic analysis for the presence of a mutation in the K-ras gene from the primary tumor.Results. For the Republic of Tatarstan, there are regional features of mutation of the K-ras gene: the frequ

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22

Alizadeh, B., A. Opera, M. Kalani, and M. Alipour. "Source rock and shale oil potential of the Pabdeh Formation (Middle–Late Eocene) in the Dezful Embayment, southwest Iran." Geologica Acta 18 (October 2, 2020): 1–22. http://dx.doi.org/10.1344/geologicaacta2020.18.15.

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The Pabdeh Brown Shale Unit (BSU) is an organic-rich calcareous mudstone within the Paleogene Pabdeh Formation, which has not yet been investigated in detail. A total of 166 core and cutting samples were selected from four wells in the Dezful Embayment to investigate the organic geochemical and the mineralogical compositions, as well as the shale oil potential of the BSU. XRD results show that it is mainly comprised of calcite (53wt.%), clay minerals (25wt.%), and quartz (14wt.%). TOC contents generally range from 1 to 9wt.% (avg. 4.2, 2.9, 5.2 and 3.3wt.%, for GS, KR, RR and RS wells, respect

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Chen, Hexin, Jun He, Steven Fong, Graham Wilcox, and Charles Wood. "Jembrana Disease Virus Tat Can Regulate Human Immunodeficiency Virus (HIV) Long Terminal Repeat-Directed Gene Expression and Can Substitute for HIV Tat in Viral Replication." Journal of Virology 74, no. 6 (2000): 2703–13. http://dx.doi.org/10.1128/jvi.74.6.2703-2713.2000.

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ABSTRACT Jembrana disease virus (JDV) is a bovine lentivirus genetically similar to bovine immunodeficiency virus; it causes an acute and sometimes fatal disease in infected animals. This virus carries a very potent Tat that can strongly activate not only its own long terminal repeat (LTR) but also the human immunodeficiency virus (HIV) LTR. In contrast, HIV Tat cannot reciprocally activate the JDV LTR (H. Chen, G. E. Wilcox, G. Kertayadnya, and C. Wood, J. Virol. 73:658–666, 1999). This indicates that in transactivation JDV Tat may utilize a mechanism similar to but not the same as that of th

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Béliveau, Catherine, Marlène Laforge, Michel Cusson, and Guy Bellemare. "Expression of a Tranosema rostrale polydnavirus gene in the spruce budworm, Choristoneura fumiferana." Microbiology 81, no. 7 (2000): 1871–80. http://dx.doi.org/10.1099/0022-1317-81-7-1871.

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The endoparasitic wasp Tranosema rostrale (Ichneumonidae) transmits a polydnavirus (PDV) to its host, Choristoneura fumiferana, during oviposition. Unlike most other PDVs examined, the virus of T. rostrale (TrPDV) does not appear to play an important role in suppressing the host cellular immune response. However, it inhibits host metamorphosis. In the present study, TrPDV gene expression was examined in parasitized and virus-injected last-instar caterpillars. Northern analysis with viral DNA as a probe revealed only one detectable mRNA, of about 650 bp. The corresponding cDNA, termed TrV1, was

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D’Ercole, Jacopo, Sean W. J. Prosser, and Paul D. N. Hebert. "A SMRT approach for targeted amplicon sequencing of museum specimens (Lepidoptera)—patterns of nucleotide misincorporation." PeerJ 9 (January 14, 2021): e10420. http://dx.doi.org/10.7717/peerj.10420.

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Natural history collections are a valuable resource for molecular taxonomic studies and for examining patterns of evolutionary diversification, particularly in the case of rare or extinct species. However, the recovery of sequence information is often complicated by DNA degradation. This article describes use of the Sequel platform (Pacific Biosciences) to recover the 658 bp barcode region of the mitochondrial cytochrome c oxidase I (COI) gene from 380 butterflies with an average age of 50 years. Nested multiplex PCR was employed for library preparation to facilitate sequence recovery from ext

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Teixeira, Francisco M., Henrique C. Teixeira, Ana Paula Ferreira, et al. "DNA Vaccine Using Mycobacterium bovis Ag85B Antigen Induces Partial Protection against Experimental Infection in BALB/c Mice." Clinical and Vaccine Immunology 13, no. 8 (2006): 930–35. http://dx.doi.org/10.1128/cvi.00151-06.

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ABSTRACT Bovine tuberculosis is a major cause of economic loss in countries where it is endemic, and in some countries, it may be a significant zoonotic disease problem. Therefore, new strategies for vaccine development are required, and among them, genetic immunization has potential value. The main goal of this study was to test the Mycobacterium bovis Ag85B gene as a DNA vaccine following challenge with an M. bovis virulent strain (ATCC 19274). Groups of BALB/c mice (n = 10) were immunized four times intramuscularly with the pCI-Ag85B construct or the pCI vector alone as the control. High ti

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Beardsley, Diana S., Bing-guan Chen та Oleg Kruglov. "Inhibition of FcγRIIA Mediated Platelet Phagocytosis with Syk-Specific siRNA Affects PECAM-1 Mediated Signal Transduction and Cell-Cell Detachment in Human Macrophages." Blood 104, № 11 (2004): 517. http://dx.doi.org/10.1182/blood.v104.11.517.517.

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Abstract We have previously shown that Syk-specific siRNA inhibits FcγRIIA mediated platelet phagocytosis in the human macrophage cell line, THP-1. Surprisingly, we observed that THP-1 cell-cell interactions were affected by Syk-specific siRNA suggesting that Syk may be important in the signaling pathway for physiological cell spreading. As reported by Brown et al. (Nature418:200, 2002), homophilic ligation of PECAM-1 on macrophages triggers cell-cell detachment, prompting us to speculate that Syk may be involved in PECAM-1 mediated signaling. PECAM-1 is a member of the immunoglobulin superfam

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Hennessy, S. W., B. A. Frazier, D. D. Kim, et al. "Complete thrombospondin mRNA sequence includes potential regulatory sites in the 3' untranslated region." Journal of Cell Biology 108, no. 2 (1989): 729–36. http://dx.doi.org/10.1083/jcb.108.2.729.

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The nucleotide sequence of human thrombospondin (TS) mRNA has been determined from human fibroblast and endothelial cDNAs. The sequence of 5802 bp begins 110 bp upstream from the initiator codon and includes the entire 3' untranslated region (UTR) of the mRNA. The coding region (3510 bp) specifies a protein of 1170 amino acids with all of the known features of the TS subunit (Frazier, W. A. 1987. J. Cell Biol. 105:625-632). The long 3' UTR of 2166 nucleotides is extremely A/T-rich, particularly in the latter half. It contains 37 TATT or ATTT(A) sequences that have been suggested as mediators o

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Berger, Martin D., Sebastian Stintzing, Dongyun Yang, et al. "Effect of polymorphisms of genes encoding regulatory proteins in the coagulation cascade on outcome for mCRC patients treated with FOLFIRI and bevacizumab: Data from FIRE-3 trial." Journal of Clinical Oncology 35, no. 4_suppl (2017): 601. http://dx.doi.org/10.1200/jco.2017.35.4_suppl.601.

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601 Background: Components of the coagulation cascade and surface proteins of platelets are involved in the regulation of angiogenesis. There are preliminary data suggesting that antithrombin III (ATIII), beside its anti-angiogenic effects, might also inhibit cancer cell migration and invasion. We therefore hypothesize that genes encoding regulatory proteins within the coagulation cascade and surface proteins of platelets may predict outcome in patients with metastatic colorectal cancer (mCRC). Methods: 295patients with mCRC enrolled in the randomized phase III FIRE-3 trial and treated with FO

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Fryc, Irena, and Przemyslaw Tabaka. "Outdoor Areas Lighting with LEDs – the Competition Between Scotopic Efficacy and Light Pollution." Photonics Letters of Poland 11, no. 3 (2019): 75. http://dx.doi.org/10.4302/plp.v11i3.924.

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In this paper the effect of typical outdoor LED lamps on star visibility index SVI was analyzed. For those lamps the spectral power distribution SPD, the nearest color temperature CCT [K] and efficacy n [lm/W] are provided. For given lamp, the SVI has been defined as ratio of its scotopic flux to scotopic flux created by full moon. The calculations shows that, the use of lamps with low CCT does not significantly affect the of the value SVI. Unfortunately from an economic point of view, those kind of lamps are less attractive in applications because of their low n. Full Text: PDF ReferencesC. R

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Zenevich, A. O., S. V. Zhdanovich, H. V. Vasilevski, A. A. Lagutik, T. G. Kovalenko, and T. M. Lukashik. "Research of multisensor characteristics based on optical fiber." Doklady BGUIR 19, no. 1 (2021): 70–78. http://dx.doi.org/10.35596/1729-7648-2021-19-1-70-78.

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The research results of multisensors based on optical fiber, the principle of which is to change the conditions of propagation of optical radiation in the optical fiber in the places where macro-bends are formed at the points of impact, are presented in the paper. The formation of macro-bends leads to an additional attenuation of the power of optical radiation propagating through the optical fiber. A single-mode optical fiber was used with the parameters, which are supported by numerous manufacturers and comply with the recommendations of ITU-T G.655. The measurements were carried out for four

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Cihlar, Tomas, Adrian S. Ray, Constantine G. Boojamra, et al. "Design and Profiling of GS-9148, a Novel Nucleotide Analog Active against Nucleoside-Resistant Variants of Human Immunodeficiency Virus Type 1, and Its Orally Bioavailable Phosphonoamidate Prodrug, GS-9131." Antimicrobial Agents and Chemotherapy 52, no. 2 (2007): 655–65. http://dx.doi.org/10.1128/aac.01215-07.

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ABSTRACT GS-9148 [(5-(6-amino-purin-9-yl)-4-fluoro-2,5-dihydro-furan-2-yloxymethyl)phosphonic acid] is a novel ribose-modified human immunodeficiency virus type 1 (HIV-1) nucleotide reverse transcriptase (RT) inhibitor (NRTI) selected from a series of nucleoside phosphonate analogs for its favorable in vitro biological properties including (i) a low potential for mitochondrial toxicity, (ii) a minimal cytotoxicity in renal proximal tubule cells and other cell types, (iii) synergy in combination with other antiretrovirals, and (iv) a unique resistance profile against multiple NRTI-resistant HIV

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Busque, Lambert. "Clonal Events in Normal Aging Hematopoiesis." Blood 126, no. 23 (2015): SCI—10—SCI—10. http://dx.doi.org/10.1182/blood.v126.23.sci-10.sci-10.

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Chronological aging of the hematopoietic compartment is associated with decreased bone marrow cellularity, reduced lymphopoiesis, increased anemia, a myeloid proliferation bias and an increased incidence of myeloid cancers. Beerman et al. proposed that this age-related myeloid lineage favoritism may be explained by clonal expansion of intrinsically myeloid-biased hematopoietic stem cells with robust self-renewal potential(1). This age-associated clonal expansion was initially suspected by X-chromosome inactivation (XCI) studies performed in the normal aging population, which documented a skewe

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Miller, Jason, Min Luo, Hua Wang, et al. "P857 ONM-500 – a novel STING-activating therapeutic nanovaccine platform for cancer immunotherapy." Journal for ImmunoTherapy of Cancer 8, Suppl 1 (2020): A7—A8. http://dx.doi.org/10.1136/lba2019.11.

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BackgroundEfficacy of cancer vaccines requires the induction of tumor antigen-specific cytotoxic T-lymphocytes (CTL) to effectively clear established tumors. Orchestration of antigen presentation, co-stimulatory signaling, and innate cytokine signals are necessary steps for tumor-specific T-cell activation. The ONM-500 nanovaccine platform1-2 utilizes a novel pH-sensitive polymer that forms an antigen-encapsulating nanoparticle and functions both as a carrier for antigen delivery of both peptide and protein antigens to dendritic cells and acts as an adjuvant, activating the stimulator on inter

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Brammer, Jonathan E., Lubomir Sokol, Yutaka Tagaya та ін. "Blockade of IL-15 Utilizing Bnz-1, a Selective γ-Chain Inhibiting Peptide, Is Safe and Has Clinical Activity in Patients with T-Cell Large Granular Lymphocytic Leukemia (T-LGLL): Results of a Phase I/II Multi-Center Clinical Trial". Blood 134, Supplement_1 (2019): 2835. http://dx.doi.org/10.1182/blood-2019-129291.

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T-cell large granular lymphocytic leukemia (T-LGLL) is an incurable, and likely under-diagnosed leukemia characterized by abnormal clonal proliferation of CD8+ memory T-cells. The clonal outgrowth of T-LGLL cells can lead to the development of profound neutropenia and anemia which results in frequent infections, transfusion dependence, and impairment in quality of life and lifespan. There have been few prospective clinical trials in this disease, and no drugs have been FDA approved for its treatment. The primary driver of leukemogenesis in T-LGLL is known to be interleukin-15 (IL-15), a gamma-

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hunault-Berger, Mathilde, Thibaut Leguay, Xavier Thomas, et al. "A Randomised Phase II Study of Pegylated Liposomal Doxorubicine in Elderly Patients with Acute Lymphoblastic Leukemia (ALL): The GRAALL-SA1 Study." Blood 112, no. 11 (2008): 918. http://dx.doi.org/10.1182/blood.v112.11.918.918.

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Abstract The GRAALL-SA1 study aimed to randomly compare the efficacy and toxicity of liposomal pegylated doxorubicin (Peg-Dox) vs continuous infusion doxorubicin (CI-Dox) in elderly patients with Philadelphia chromosome-negative ALL. Induction chemotherapy, supported by G-CSF, comprised either CI-Dox 12 mg/m2/d and CI-VCR 0.4 mg/d on d1-4 or Peg-Dox 40 mg/m2 IV and standard VCR 2 on d1, in combination with dexamethasone. A second cycle, reinforced by cyclophosphamide 1 g/m2, was started at d28. Consolidation included two additional cycles using reduced doses of CI-Dox (12mg/m2/d d1-3) or Peg-

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Takata, Katsuyoshi, Daisuke Ennishi, Ali Bashashati, et al. "Somatic PRAME Deletions Are Associated with Decreased Immunogenicity, Apoptosis Resistance and Poor Outcomes in Diffuse Large B-Cell Lymphoma." Blood 132, Supplement 1 (2018): 667. http://dx.doi.org/10.1182/blood-2018-99-113516.

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Abstract Background: The current standard of care in diffuse large B-cell lymphoma (DLBCL) consists of chemotherapy and therapeutic monoclonal antibodies that have significantly improved patient outcomes over the past 15 years. However, a large proportion of patients suffer from refractory or relapsed disease. Therefore, the development of new therapeutic strategies for this subgroup of patients, who are threatened by a high chance of disease-related death, represents an important unmet clinical need. Methods: We enrolled into our study 347 de novo DLBCL patients uniformly treated with R-CHOP

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Civallero, Monica, Viviana Vergaro, Cinzia Citti, et al. "Calcium-Carbonate Nanocapsules Improve the Efficacy of BEZ235 in Lymphoma a Cell Line: A Promising New Technology of Drug Delivery." Blood 126, no. 23 (2015): 4851. http://dx.doi.org/10.1182/blood.v126.23.4851.4851.

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Abstract Nanotechnology is a promising branch of the medical field, directed to improve diagnostic and therapeutics strategies, applying nanovectors as drug delivery systems. Efficient encapsulation of anticancer drugs in nanocolloids and microcapsules was recently developed by G. Ciccarella research group (1). Based on our collaboration with the Nantional Nanotechnology Laboratory of the University of Salento and our previous experience with target therapies, we encapsulated BEZ235, a phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin inhibitor (mTOR). BEZ235 efficiently b

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Kamiki, Jéssica, Patrícia António, Pedro Noronha, et al. "166 Mucosal-associated invariant T-cells (MAIT) in pancreatic cancer." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A179. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0166.

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BackgroundImmunotherapy has changed the standard of care for multiple cancers; however, its efficacy is limited. Chemotherapy and radiation had little effect in pancreatic ductal adenocarcinoma (PDAC) outcome1 in patients with metastatic disease, hence the urgency for new effective courses of treatment. Increasing evidence suggests mucosal-associated invariant T-cells (MAIT) play a role in anti-cancer T-cell responses, by recognizing transformed cells or bacterial products. MAIT respond towards microbial antigens and vitamin derivatives, produce pro-inflammatory cytokines2 3 and have been foun

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Prayogi, Gusti Dian, and Erina Sudaryati. "PENGARUH TEKANAN WAKTU, TEKANAN KETAATAN, KECERDASAN EMOSIONAL DAN KECERDASAN SPIRITUAL PERSONIL APARAT PENGENDALIAN INTERNAL PEMERINTAH TERHADAP PENDETEKSIAN FRAUD." Behavioral Accounting Journal 2, no. 1 (2019): 54–70. http://dx.doi.org/10.33005/baj.v2i1.41.

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Agustini, N. K. R., & Merkusiwati, N. K. L. A. (2016). Pengaruh Tekanan Ketaatan, Senioritas Auditor Dan Tekanan Anggaran Waktu Terhadap Audit Judgment. Universitas Udayana, 15, 433–462. Akhtar, S., bin Arshad, M. A., Mahmood, A., & Ahmed, A. (2015). Spiritual Quotient and Ethical Values towards Organizational Sustainability. International Letters of Social and Humanistic Sciences, 58(2001), 1–7. https://doi.org/10.18052/www.scipress.com/ilshs.58.1 Anggriawan, E. F. (2014). Summary for Policymakers. In Intergovernmental Panel on Climate Change (Ed.), Climate Change 2013 - T

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Hummel, Manuela, Thomas Hielscher, Hans Jürgen Salwender, et al. "Quantitative Integrative Prediction of Survival Probability in Multiple Myeloma Using Molecular and Clinical Prognostic Factors in 657 Patients Treated with Bortezomib-Based Induction, High-Dose Therapy and Autologous Stem Cell Transplantation." Blood 132, Supplement 1 (2018): 403. http://dx.doi.org/10.1182/blood-2018-99-113307.

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Abstract Background Survival in multiple myeloma ranges from months to decades and the majority of patients remain incurable with current treatment approaches. Given this high variability, it would be clinically very useful to quantitatively predict survival on a continuous scale. Current risk prediction models attribute patients to 2-3 groups, i.e. high, intermediate, and low risk. Group size and survival rates largely vary between different systems. Rarely, molecular prognostic factors beyond iFISH are used. Widely accepted standard is the revised ISS score (rISS) including serum B2M, albumi

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Gunasinghe, N., M. P. You, V. Lanoiselet, N. Eyres, and M. J. Barbetti. "First Report of Powdery Mildew Caused by Erysiphe cruciferarum on Brassica campestris var. pekinensis, B. carinata, Eruca sativa, E. vesicaria in Australia and on B. rapa and B. oleracea var. capitata in Western Australia." Plant Disease 97, no. 9 (2013): 1256. http://dx.doi.org/10.1094/pdis-03-13-0299-pdn.

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Inspection of field plantings of diverse cruciferous species, mainly oilseed varieties sown for agronomic assessment at Crawley, (31.99°S, 115.82°E), Western Australia, in September 2012, indicated the occurrence of extensive leaf and stem colonization by powdery mildew at the late flowering stage, with whitish patches 3 to 4 cm in length on stems of Brassica campestris var. pekinensis, B. carinata, B. oleracea var. capitata, B. rapa, Eruca sativa, and E. vesicaria. These patches coalesced to form a dense, white, powdery layer. Infected leaves showed signs of early senescence. Pathogenicity wa

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Álvarez Román, María Teresa, Raul Justo Sanz, Elena Monzon Manzano, et al. "Procoagulant Profile of Platelets from Immune Thrombocytopenia Patients." Blood 128, no. 22 (2016): 1370. http://dx.doi.org/10.1182/blood.v128.22.1370.1370.

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Abstract Introduction: Immune thrombocytopenia (ITP) is an autoimmune disorder in which both increased platelet destruction and insufficient platelet production are involved. Patients can have a range of bleeding manifestations from none to severe at a similar platelet count. In some cases, patients have fewer bleeding symptoms than expected considering the low platelet count that they might have. Objective: The aim of this study was to determine the procoagulant profile of platelets from ITP patients in order to determine whether any of their features may explain this observation. Methods: Tw

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Okrushko, Svitlana. "ESTIMATION OF THE INFLUENCE OF HERBICIDES AND PGR OF ZEASTIMULIN ON WEEDING AND YIELD OF CORN." Agriculture and Forestry, no. 2 (October 30, 2020): 95–105. http://dx.doi.org/10.37128/2707-5826-2020-2-9.

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The system of protection of cultivated plants from the negative effects of weeds is an important element in the technology of growing corn. The application of the chemical method allows to effectively and for a long time get rid of the agrophytocenosis of weeds. Weeds significantly impair the growing conditions of cultivated plants and prevent them from realizing the opportunities inherent in the genetic potential of the crop. Maize has a low level of competitiveness against weeds. The aim of the article was: to substantiate the application of insurance herbicides Laudis and Stellar for weed c

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Kolar, M., M. Lukas, K. Malickova, et al. "P368 Tofacitinib induction efficiency and intracellular cytokine dynamics in ulcerative colitis: Results from clinical practice." Journal of Crohn's and Colitis 14, Supplement_1 (2020): S348. http://dx.doi.org/10.1093/ecco-jcc/jjz203.497.

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Abstract Background Tofacitinib is an oral JAK inhibitor approved for the treatment of ulcerative colitis (UC). Its efficiency was proven in registration trials; however, data from clinical practice are insufficient. Our aim was to evaluate response to tofacitinib after 8 weeks in UC patients, and to assess potential predictors of response including early cytokine production shifts. Methods Data from consecutive UC patients who started tofacitinib 10 mg b.i.d. were evaluated. Disease activity was assessed by Mayo score at baseline and week 8 together with C-reactive protein (CRP) and faecal ca

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Garibaldi, A., D. Bertetti, P. Pensa, A. Poli, and M. L. Gullino. "First Report of Web Blight on Rosemary (Rosmarinus officinalis) Caused by Rhizoctonia solani AG-1-IA in Italy." Plant Disease 97, no. 6 (2013): 844. http://dx.doi.org/10.1094/pdis-11-12-1012-pdn.

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Rosmarinus officinalis L., family Labiatae, is an evergreen shrub used in gardens as an aromatic or ground cover plant. In the summer of 2012, a blight was observed in a farm located near Albenga (northern Italy) on 20% of 150,000 70-day-old plants, grown in trays. Water soaked lesions appeared on leaves and stems. As the disease progressed, blighted leaves turned brown, withered, clung to the shoots, and matted on the surrounding foliage. A light mycelium spread on the substrate. Disease progressed from infected plants to healthy ones and, eventually, infected plants died. Leaf and stem fragm

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Sri Wahyuni, Siti Fadilah, and Adolf Bastian. "Children's independence Skills Analysis at Low Socioeconomic Environment." JPUD - Jurnal Pendidikan Usia Dini 14, no. 2 (2020): 303–12. http://dx.doi.org/10.21009/jpud.142.08.

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Research suggests that child independence is more popular in countries with greater wealth and a higher percentage of the educated population. Various research implications expect children's independence and compliance to increase over time in developing countries. This study aims to describe the independence of early childhood who comes from low-income families or at low socioeconomic environment. Using quantitative descriptive, data collection techniques are carried out through a questionnaire. The study population was 30 respondents from the ECE institution who were included in the list of

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Lockhart, B., D. Mollov, and M. Daughtrey. "First Report of Alfalfa mosaic virus Occurrence in Hydrangea in the United States." Plant Disease 97, no. 9 (2013): 1258. http://dx.doi.org/10.1094/pdis-07-12-0618-pdn.

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In spring of 2012, a previously unrecorded virus-like disease characterized by conspicuous yellow leaf blotching (calico symptoms) was observed in plants of Hydrangea macrophylla in a single location in Southampton, NY. Bacilliform and spherical particles resembling those of Alfalfa mosaic virus (AMV) were observed by transmission electron microscopy (TEM) in partially purified extracts from symptomatic leaf tissue. The identity of the virus was confirmed by immunosorbent electron microscopy (ISEM) (4) using antiserum to AMV (ATCC PVAS 92) that both trapped and decorated the virions. Three pri

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Salas, Monserrat, Christian Jijón, and Kléver Moreno. "ESTRATEGIAS DE GESTIÓN EMPRESARIAL: UN ACERCAMIENTO A LA PLANEACIÓN SISTEMÁTICA." Universidad Ciencia y Tecnología 24, no. 107 (2020): 12–21. http://dx.doi.org/10.47460/uct.v24i107.409.

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Las estrategias de gestión empresarial tienen como finalidad crear y mantener ventajas competitivas a través de un plan de acción de manera que sea sostenible en el tiempo, sin embargo el éxito de las mismas dependerá de la mejora continua en el modelo de gestión empresarial y así aumentar la productividad, competitividad, y eficiencia. El objetivo del estudio es determinar la heterogeneidad del modelo de gestión estratégica empresarial mediante el meta-análisis de dimensiones. El diseño metodológico tuvo un enfoque cuantitativo de corte histórico-hermenéutico, pues el levantamiento de informa

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Liu, Li, Marilyn Sanchez-Bonilla, Yan Wang, Mathew Crouthamel, Cecilia Giachelli, and Sioban B. Keel. "Mice Lacking the Sodium-Dependent Phosphate Import Protein, Pit-1, Have a Severe Defect in Terminal Erythroid Differentiation." Blood 118, no. 21 (2011): 681. http://dx.doi.org/10.1182/blood.v118.21.681.681.

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Abstract Abstract 681 Phosphate is the second most abundant mineral in the human body and plays an essential role in phospholipids, nucleoproteins and nucleic acids, bone mineralization, the storage and liberation of metabolic energy, and enzyme activity. While our understanding of the mechanisms of phosphate homeostasis has advanced, little is known about how the body initially senses changes in phosphate concentration or the downstream biological processes regulated by these concentration changes. Among the three families of membrane mammalian sodium-phosphate import proteins, PiT-1 and its

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