Log in

Relevant bibliographies by topics / IVIVC / Dissertations / Theses

To see the other types of publications on this topic, follow the link: IVIVC.

Dissertations / Theses on the topic 'IVIVC'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 18 dissertations / theses for your research on the topic 'IVIVC.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Wingert, Nathalie Ribeiro. "Desenvolvimento e validação de métodos analíticos e estudos de estabilidade da rivaroxabana." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/149500.

Full text

Abstract:

A análise de fármacos é fundamental nas diversas fases do desenvolvimento farmacêutico, tais como estudos de formulação, estabilidade e controle de qualidade do produto. A rivaroxabana (RIV) é um anticoagulante de uso oral indicado para prevenção da formação de coágulos venosos. A literatura pesquisada apresenta poucos relatos de determinação quantitativa e de estudos de estabilidade do fármaco em comprimidos. E ainda nenhum método analítico em compêndios oficiais Diante do exposto, o objetivo deste trabalho foi desenvolver e validar métodos analíticos para determinação qualitativa e quantitat

APA, Harvard, Vancouver, ISO, and other styles

2

Bergstrand, Martin. "Application of Mixed-Effect Modeling to Improve Mechanistic Understanding and Predictability of Oral Absorption." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-149314.

Full text

Abstract:

Several sophisticated techniques to study in vivo GI transit and regional absorption of pharmaceuticals are available and increasingly used. Examples of such methods are Magnetic Marker Monitoring (MMM) and local drug administration with remotely operated capsules. Another approach is the paracetamol and sulfapyridine double marker method which utilizes observed plasma concentrations of the two substances as markers for GI transit. Common for all of these methods is that they generate multiple types of observations e.g. tablet GI position, drug release and plasma concentrations of one or more

APA, Harvard, Vancouver, ISO, and other styles

3

Delvadia, Renishkumar. "In vitro methods to predict aerosol drug deposition in normal adults." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/314.

Full text

Abstract:

This research was aimed at the development and validation of new in vitro methods capable of predicting in vivo drug deposition from dry powder inhalers, DPIs, in lung-normal human adults. Three physical models of the mouth, throat and upper airways, MT-TB, were designed and validated using the anatomical literature. Small, medium and large versions were constructed to cover approximately 95% of the variation seen in normal adult humans of both genders. The models were housed in an artificial thorax and used for in vitro testing of drug deposition from Budelin Novolizer DPIs using a breath

APA, Harvard, Vancouver, ISO, and other styles

4

Carlert, Sara. "Investigation and Prediction of Small Intestinal Precipitation of Poorly Soluble Drugs : a Study Involving in silico, in vitro and in vivo Assessment." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-178053.

Full text

Abstract:

The main objectives of the present project were to increase the understanding of small intestinal precipitation of poorly soluble pharmaceutical drugs, investigate occurrence of crystalline small intestinal precipitation and effects of precipitation on absorption. The aim was to create and evaluate methods of predicting crystalline small intestinal drug precipitation using in vivo, in vitro and in silico models. In vivo small intestinal precipitation from highly supersaturated solutions of two weakly basic model drugs, AZD0865 and mebendazole, was investigated in humans and canine models. Pote

APA, Harvard, Vancouver, ISO, and other styles

5

Long, Chiau Ming. "Biopharmaceutical considerations and in vitro-in vivo correlations (IVIVCs) for orally administered amorphous formulations." Thesis, University of Bath, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.629670.

Full text

Abstract:

Dissolution testing and physiological based pharmacokinetic modeling are the essential methods during drug development. However, there is a lack of a sound approach and understanding of the parameter that controls dissolution and absorption of amorphous formulations. Robust dissolution conditions and setup and PBPK models that have a predictability of in vivo results will expedite and facilitate the drug development process. In this project, cefuroxime axetil, CA (Zinnat® as the amorphous formulations); itraconazole, ITR (Sporanox® as the amorphous formulation) and a compound undergoing clinic

APA, Harvard, Vancouver, ISO, and other styles

6

MASSIRONI, ANDREA. "Search for a Higgs Boson in the H - > WW - > IvIv channel at CMS." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/40097.

Full text

Abstract:

In this thesis work, the search for a Higgs boson at CMS in the WW fully leptonic decay channel is presented. Two different production mechanisms have been analysed: the Vector Boson Fusion (VBF) and the Higgs-strahlung (VH). Given the leptonic decays of WW, in order to guarantee a good electron reconstruction and identification, the electromagnetic calorimeter alignment has been studied. In addition, both the VBF and the VH analyses relies on the capability of CMS to reconstruct jets: one of the first measurements of CMS, with data collected during 2010 run, looking at the simultaneous pro

APA, Harvard, Vancouver, ISO, and other styles

7

Da, Silva Franck. "Amélioration de la prédiction de la clairance métabolique via l’utilisation de modèles hépatiques innovants." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT083.

Full text

Abstract:

La sélection des meilleurs candidats médicament se base sur des choix multiparamétriques réunissant l’efficacité potentielle, les caractéristiques ADME et le profil de sécurité des nouvelles entités chimiques. En ce sens, la prédiction précoce de la pharmacocinétique est élémentaire pour orienter les prises de décision et donner un cap pertinent aux projets. En raison de son rôle central dans le devenir des médicaments, la clairance métabolique médiée principalement par le foie est l’un des paramètres les plus importants. L’objectif de ce projet était d’améliorer la prédiction de la clairance

APA, Harvard, Vancouver, ISO, and other styles

8

Harwood, Matthew Dillston. "Towards a fully mechanistic prediction of oral drug absorption : investigating intestinal transporter abundance & function relationships." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/towards-a-fully-mechanistic-prediction-of-oral-drug-absorption-investigating-intestinal-transporter-abundance-and-function-relationships(a211b130-b8ac-4ce3-bf8f-728cf08df216).html.

Full text

Abstract:

Background: Elucidating the role of intestinal drug transporter function in drug development is crucial, as transporter proteins can impact on drug absorption, efficacy and adverse events. In Vitro-In Vivo Extrapolation linked to Physiologically-Based Pharmacokinetic (IVIVE-PBPK) models aim to predict the in vivo impact of transporters from in vitro cell–based transport data and expression-based scaling factors. Currently, these models depend on relative measurements of transporter expression i.e., mRNA or immunoblotting. There is a critical need for physiologically relevant measures of transp

APA, Harvard, Vancouver, ISO, and other styles

9

Reddyhoff, Dennis. "Mathematical modelling of acetaminophen induced hepatotoxicity." Thesis, Loughborough University, 2016. https://dspace.lboro.ac.uk/2134/23008.

Full text

Abstract:

Acetaminophen, known as paracetamol in the UK and Tylenol in the United States, is a widespread and commonly used painkiller all over the world. Taken in large enough doses, however, it can cause fatal liver damage. In the U.S., 56000 people are admitted to hospital each year due to acetaminophen overdose and its related effects, at great cost to healthcare services. In this thesis we present a number of different models of acetaminophen metabolism and toxicity. Previously, models of acetaminophen toxicity have been complex and due to this complexity, do not lend themselves well to more advanc

APA, Harvard, Vancouver, ISO, and other styles

10

Maharao, Neha V. "Inhibition of Oxidative and Conjugative Metabolism of Buprenorphine Using Generally Recognized As Safe (GRAS) Compounds or Components of Dietary Supplements." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4752.

Full text

Abstract:

This dissertation aimed at developing an inhibitor strategy to improve the oral bioavailability (Foral) and systemic exposure (AUC∞) of buprenorphine (BUP) as well as reduce the variability associated with them. Twenty-seven generally recognized as safe (GRAS) compounds or dietary substances were evaluated for their potential to inhibit the oxidative and conjugative metabolism of BUP, using pooled human intestinal and liver microsomes. In both the organs, oxidation appeared to be the major metabolic pathway with a 6 fold (intestine) and 4 fold (liver) higher intrinsic clearance than glucuronid

APA, Harvard, Vancouver, ISO, and other styles

11

BISWAS, DEBLINA. "A BIORELEVANT IN VITRO MODEL TO CHARACTERIZE IN VIVO RELEASE OF BONE MORPHOGENETIC PROTEIN-2 (rhBMP-2)." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4977.

Full text

Abstract:

Biorelevant in vitro release/dissolution tests are designed to predict the in vivo behavior of a drug and are crucial in understanding its in vivo performance. Currently, there is no standardized compendial in vitro release testing methods or regulatory guidance’s for release/dissolution testing of implants due to their complex physiological locations.Furthermore, existing compendial methods do not capture the local release profile of ‘novel’ parenterals in physiological low fluid volume surrounding areas. Long acting and in situ forming implants with orthobiologic proteins and peptides have i

APA, Harvard, Vancouver, ISO, and other styles

12

Delvadia, Poonam. "A NOVEL BIORELEVANT IN VITRO SYSTEM TO PREDICT THE IN VIVO PERFORMANCE OF ORAL TRANSMUCOSAL PRODUCTS." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3173.

Full text

Abstract:

In vitro dissolution, release and permeation testing is a common practice during drug product research and development. These in vitro tests, if predictive, are referred to as biorelevant tests and can play diverse roles to facilitate and expedite product development in a cost effective manner. Oral transmucosal products (OTPs) are currently tested using compendial and modified in vitro tests which may or may not be good predictors of in vivo performance due to a lack of biorelevance. A critical need for a broadly applicable and biorelevant in vitro system for OTPs has been expressed in the li

APA, Harvard, Vancouver, ISO, and other styles

13

Leding, Albin. "Recommendation for first pharmacokinetic in vivo experiment design with a pharmacometric informed approach." Thesis, Uppsala universitet, Institutionen för farmaci, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-447311.

Full text

Abstract:

Tuberculosis, the leading cause of death by a single infection disease caused by bacteria, requires long treatments and the bacteria are prone to develop drug resistance. Therefore, new efficient treatment regiments needs developing, which requires new tools for drug development. A major reason for discontinuance of a drug under development is undesired pharmacokinetic properties. Therefore, it is important to have early information of this, preferably the first time the drug is tested in animals. The first in vivo pharmacokinetic experiment is often done in mice and the only information prese

APA, Harvard, Vancouver, ISO, and other styles

14

Leding, Albin. "Optimized design recommendation for first pharmacokinetic in vivo experiments for new tuberculosis drugs using pharmacometrics modelling and simulation." Thesis, Uppsala universitet, Institutionen för farmaci, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-447311.

Full text

Abstract:

Tuberculosis, the leading cause of death by a single infection disease caused by bacteria, requires long treatments and the bacteria are prone to develop drug resistance. Therefore, new efficient treatment regiments needs developing, which requires new tools for drug development. A major reason for discontinuance of a drug under development is undesired pharmacokinetic properties. Therefore, it is important to have early information of this, preferably the first time the drug is tested in animals. The first in vivo pharmacokinetic experiment is often done in mice and the only information prese

APA, Harvard, Vancouver, ISO, and other styles

15

Dong, Jin. "First-principle based pharmacokinetic modeling." Scholarly Commons, 2016. https://scholarlycommons.pacific.edu/uop_etds/128.

Full text

Abstract:

Predicting drug concentrations in the blood and at the site of action is the hottest topic in pharmacokinetics (PK). In vitro-in vivo extrapolation (IVIVE) and physiological based pharmacokinetics (PBPK) models are two major PK prediction strategies. However, both IVIVE and PBPK models are considered as immature methodologies due to their poor predictability. The goal of the research is to investigate the discrepancies within IVIVE and PBPK predictions according to first-principles: convection, diffusion, metabolism, and carrier-mediated transport. In Chapter 2, non-permeability limited hepati

APA, Harvard, Vancouver, ISO, and other styles

16

de, Matas Marcel, Henry Chrystyn, Qun Shao, and Victoria L. Silkstone. "Evaluation of an in vitro in vivo correlation for nebulizer delivery using artificial neural networks." 2007. http://hdl.handle.net/10454/4161.

Full text

Abstract:

No<br>The ability to generate predictive models linking the in vitro assessment of pharmaceutical products with in vivo performance has the potential to enable greater control of clinical quality whilst minimizing the number of in vivo studies in drug development. Artificial neural networks (ANNs) provide a means of generating predictive models correlating critical product characteristics to key performance attributes. In this regard, ANNs have been used to model historical data exploring the relative lung bioavailability of salbutamol from several different nebulizers. The generated ANN model

APA, Harvard, Vancouver, ISO, and other styles

17

Puscas, Ina. "Développement d’un modèle in vitro de la barrière hémato-encéphalique." Thesis, 2019. http://hdl.handle.net/1866/24000.

Full text

Abstract:

La barrière hémato-encéphalique (BHE) est une structure retrouvée au niveau des capillaires cérébraux. Elle représente un véritable obstacle pour les actifs qui doivent se rendre au cerveau pour y exercer un effet pharmacologique. Durant les étapes du développement du médicament, des modèles cellulaires in vitro sont utilisés pour l’évaluation de la perméabilité au cerveau des nouveaux médicaments. Le modèle assemblé avec des cellules endothéliales (CEs) isolées des capillaires des cerveaux de souris présente un intérêt particulier pour la recherche en raison de sa facilité d’obtention et sa p

APA, Harvard, Vancouver, ISO, and other styles

18

Echezuria, Perozo Jorge Enrique, Maria Carolina Rondon, and Luna Melany Gutierrez. "Diseño de estrategias para optimizar la calidad de los servicios de la Biblioteca Marcel Roche del Instituto Venezolano de Investigaciones Científicas (IVIC)." Thesis, 2006. http://eprints.rclis.org/8305/1/TL-EBA_jun2006_E2.pdf.

Full text

Abstract:

As to design new strategies for the quality improvement of all services offered by the Marcel Roche Library (MRL) of the Venezuelan Institute of Scientific Investigations (IVIC) this work studies the beginnings and evolution of quality management improvement reviewing some of the studies presented by some of the most outstanding authors in this subject as well as analyzing the basic components and principles of the total quality management (TQM). This document also focuses on the analysis of the nature, evolution, characteristics and importance of current services inside the manufacturing indu

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!