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Journal articles on the topic 'J.A.G Acke'

Author: Grafiati

Published: 29 June 2021

Last updated: 29 July 2025

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1

Zengin, Gokhan, Mohamad Fawzi Mahomoodally, Kouadio Ibrahime Sinan, et al. "Chemical Composition and Biological Properties of Two Jatropha Species: Different Parts and Different Extraction Methods." Antioxidants 10, no. 5 (2021): 792. http://dx.doi.org/10.3390/antiox10050792.

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Jatropha L. species, in particular, J. curcas and J. gossypiifolia, are well known medicinal plants used for treating various diseases. In the present study, leaf and stem bark extracts of J. curcas and J. gossypiifolia obtained by maceration or homogenizer assisted extraction, were investigated for their phytochemical contents and biological potential as antioxidants, enzyme inhibitors and neuromodulators. In this regard, the gene expression of tumor necrosis factor α (TNFα) and brain-derived neurotrophic factor (BDNF) was investigated in hypothalamic HypoE22 cells. Finally, a bioinformatics

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Olumoroti, Israel Adebayo, Ajani Olatunde Oyelaran, and Bukola Bolaji. "Production and Characterization of Ackee Apple (Blighia sapida) Seeds and African Star Apple (Chrysophyllum albidum) Seeds Oil Mixtures and their Biodiesel." ABUAD Journal of Engineering Research and Development (AJERD) 7, no. 1 (2024): 100–108. http://dx.doi.org/10.53982/ajerd.2024.0701.10-j.

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This paper focused on the characterization of oils and biodiesels derived from Ackee apple seeds and African star apple seeds obtained from local markets. The oils from individual seeds and their mixtures at varying ratios were characterised for relative density, free fatty acid, acid, iodine, and saponification, which yielded 0.91 g/cm3, 1.06 mg-KOH/g, 2.12 mg-KOH/g, 38.36mg-iodine/100g, and 195.74 mg-KOH/g of ackee seed oil, respectively. And 0.89 g/cm3, 2.105 mg-KOH/g, 4.2 mg-KOH/g, 52.49 mg-iodine/100 g, and 227.7 mg-KOH/g of African star apple seed oil, respectively. The highest relative

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3

Xu, Shengnan, Xinru Li, Shi Liu, Peilin Tian, and Dengwu Li. "Juniperus sabina L. as a Source of Podophyllotoxins: Extraction Optimization and Anticholinesterase Activities." International Journal of Molecular Sciences 23, no. 18 (2022): 10205. http://dx.doi.org/10.3390/ijms231810205.

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Juniperus sabina L. (J. sabina) has been an important plant in traditional medicine since ancient times. Its needles are rich in podophyllotoxin, a precursor compound to anti-tumor drugs. However, no systematic research has been done on J. sabina as a source of podophyllotoxins or their biological action. Hence, extracts of podophyllotoxin and deoxypodophyllotoxin were the main optimization targets using the Box–Behnken design (BBD) and response surface methodology (RSM). The total phenol content and antioxidant activity of J. sabina needle extract were also optimized. Under the optimal proces

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AYENI, OLUBIMPE, WAYNE CAREY, and CHANNY MUHN. "Acne Scar Treatment with Subcision Using a 20-G Cataract Blade." Dermatologic Surgery 37, no. 6 (2011): 846–47. http://dx.doi.org/10.1111/j.1524-4725.2011.02010..x.

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AYENI, OLUBIMPE, WAYNE CAREY, and CHANNY MUHN. "Acne Scar Treatment with Subcision Using a 20-G Cataract Blade." Dermatologic Surgery 37, no. 6 (2011): 846–47. http://dx.doi.org/10.1111/j.1524-4725.2011.02010.x.

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6

Cheraif, Kadour, Boulanouar Bakchiche, Abdelaziz Gherib, et al. "Chemical Composition, Antioxidant, Anti-Tyrosinase, Anti-Cholinesterase and Cytotoxic Activities of Essential Oils of Six Algerian Plants." Molecules 25, no. 7 (2020): 1710. http://dx.doi.org/10.3390/molecules25071710.

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In this study, the essential oils (EOs) of six Algerian plants (Artemisia campestris L., Artemisia herba-alba Asso, Juniperus phoenicea L., Juniperus oxycedrus L., Mentha pulegium L. and Lavandula officinalis Chaix) were obtained by hydrodistillation, and their compositions determined by GC-MS and GC-FID. The antioxidant activity of the EOS was evaluated via 2,2′-diphenyl-1-picrylhydrazyl (DPPH), ferric-reducing/antioxidant power (FRAP) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) assays. Moreover, their cytotoxic effect was evaluated—as well as their tyrosinase, acetyl- a

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Comfort Sankem Yusuf, Ibrahim Birma Bwatanglang, Tari Dlama Tizhe, Peter Emmanuel Tosin, and Musa Ira Felister. "Ethnobotany and phytochemical analysis of Jatropha Tanjorensis in Mubi Adamawa State, Nigeria." International Journal of Frontiers in Life Science Research 1, no. 1 (2021): 040–47. http://dx.doi.org/10.53294/ijflsr.2021.1.1.0035.

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This study was focused on the ethanobotanical survey, phytochemical and proximate analysis of Jatropha tanjorensis in Mubi. The ethnobotanical survey was carried out in some selected parts of both Mubi North and South local government area through oral interview using traditional medicine practioners and some householders as the interviewee. After air drying, pulverizing and extracting the bioactive constituents of the leaf using ethanol and water as solvents, the phytochemical and proximate analysis were carried out using a standard procedures. The ethnobotanical survey showed that, J. tanjor

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Salleh, Wan Mohd Nuzul Hakimi Wan, Farediah Ahmad, and Khong Heng Yen. "Evaluation of Antioxidant, Anticholinesterase and Antityrosinase Activities of Malaysian Cinnamomum Species." Dhaka University Journal of Pharmaceutical Sciences 14, no. 2 (2016): 125–32. http://dx.doi.org/10.3329/dujps.v14i2.28500.

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The extracts of the leaves and bark of five Cinnamomum species (C. altissimum, C. griffithii, C. javanicum, C. macrocarpum, and C. velutinum) were screened to evaluate their antioxidant, anticholinesterase, and antityrosinase activities. The bark of C. altissimum showed the highest phenolic content (130.1 mg GA/g), free radical scavenging by DPPH (IC50 126.2 ?g/mL) and ferric reducing antioxidant power (FRAP) assays (341.2 mg AA/g). All of the extracts inhibited linoleic acid peroxidation by greater than 70%, with the leaves of C. altissimum exhibiting the highest inhibition of 87.7%. The leav

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9

Szabó, K., G. Tax, K. Kis, et al. "Interleukin-1A +4845(G> T) polymorphism is a factor predisposing to acne vulgaris." Tissue Antigens 76, no. 5 (2010): 411–15. http://dx.doi.org/10.1111/j.1399-0039.2010.01530.x.

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Tsakiris, Stylianos, Panagiota Kouniniotou-Krontiri, Kleopatra H. Schulpis та John C. Stavridis. "ʟ-Phenylalanine Effect on Rat Brain Acetylcholinesterase and Na+,K+-ATPase". Zeitschrift für Naturforschung C 53, № 3-4 (1998): 163–67. http://dx.doi.org/10.1515/znc-1998-3-404.

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Abstract The effect of different L-phenylalanine (Phe) concentrations (0 .1-12.1 mᴍ) , on acetylcholinesterase (AChE ) and Na+,K+-ATPase activities of brain homogenate and pure enzymes, was investigated at 37 °C. AChE and Na+,K+-ATPase activities were determined according to Ellman G. L., Courtney D., Andres V. and Featherstone R. M. (1961), Biochem. Pharmacol. 7, 88 - 95 and Bowler K. and Tirri R. (1974), J. Neurochem. 23, 611-613 ) respectively, after preincubation with Phe. AChE activity in brain homogenate or in pure eel E.electricus enzyme showed a decrease, which reached up to 18% with c

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Rao, B. Ramalingeswara, Mohana R. Katiki, Kommula Dileep, et al. "Synthesis and Biological Evaluation of Benzothiazole-piperazinesulfonamide Conjugates and Their Antibacterial and Antiacetylcholinesterase Activity." Letters in Organic Chemistry 16, no. 9 (2019): 723–34. http://dx.doi.org/10.2174/1570178615666181113094539.

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Two series of N-2-benzothiazolyl-4-(arylsulfonyl)-1-piperazineacetamides/propanamides were synthesized from substituted 2-aminobenzothiazoles and were assayed for their in vitro antimicrobial activities against a panel of different pathogenic bacterial strains such as Micrococcus luteus, S. aureus, S. aureus MLS-16, B. subtilis, Escherichia coli, Pseudomonas aeruginosa, Klebsiella planticola and Candida albicans. Among the synthesized compounds 5e,f,g and 6g,h,i showed promising antifungal activity against C. albicans as compared to the reference drug, miconazole. Further, compounds 6g,h,i sho

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Mahomoodally, Mohamad Fawzi, Nabeelah Bibi Sadeer, Gokhan Zengin, et al. "In Vitro Enzyme Inhibitory Properties, Secondary Metabolite Profiles and Multivariate Analysis of Five Seaweeds." Marine Drugs 18, no. 4 (2020): 198. http://dx.doi.org/10.3390/md18040198.

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Seaweeds have been exploited as both food products and therapeutics to manage human ailments for centuries. This study investigated the metabolite profile of five seaweeds (Halimeda spp., Spyridia hypnoides (Bory de Saint-Vincent) Papenfuss, Valoniopsis pachynema (G. Martens) Børgesen, Gracilaria fergusonii J. Agardh and Amphiroa anceps (Lamarck) Decaisne using ultra-high-performance liquid chromatography coupled with electrospray ionization mass spectrometry (UHPLC-ESI-MS/MS). Furthermore, these seaweeds were assessed for antioxidant and inhibitory effects against α-amylase, α-glucosidase, ac

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Ilić, Djordje, Maja Karaman, Mirjana Bogavac, Jovana Mišković, and Milena Rašeta. "Bioactivity Profiling of Daedaleopsis confragosa (Bolton) J. Schröt. 1888: Implications for Its Possible Application in Enhancing Women’s Reproductive Health." Pharmaceuticals 17, no. 5 (2024): 600. http://dx.doi.org/10.3390/ph17050600.

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This study investigates the bioactivity profile of wood-rotting fungal species Daedaleopsis confragosa (Bolton) J. Schröt. 1888, focusing on its antioxidant, cytotoxic, and genotoxic activities and enzyme modulation properties with respect to its possible application in terms of enhancing women’s reproductive health. Two types of extracts, including those based on EtOH extraction (DC) and hydrodistillation (DCHD), were investigated. The results indicate that the radical scavenging capacity against the DPPH radical and reduction potential were stronger in the DC extracts owing to the higher tot

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Talal, Abdel Raheem, M. Abo Ria Nesreen, K. Abd ElGhafar Noha, and Maher Zeinab. "Serum Desnutrin Level and Acne Severity." Biolife 6, no. 1 (2022): 10–14. https://doi.org/10.5281/zenodo.7397399.

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<strong>ABSTRACT</strong> The role of metabolic factors in pathophysiology of acne is highly controversial. A   potential role for various factors such as desnutrin has been suggested in the pathogenesis of acne. The aim of this study was to measure the serum levels of desnutrin and insulin and estimate insulin resistance (HOMA-IR), in acne patients in comparison to normal controls, and evaluate the relationship of these levels to severity of acne, in order to investigate the role of these factors in the pathogenesis of acne. The present study included 60 acne patients and 20 healthy

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15

Li, Yanwei, Likai Du, Yueming Hu, Xiaomin Sun, and Jingtian Hu. "Theoretical study on the aging and reactivation mechanism of tabun-inhibited acetylcholinesterase by using the quantum mechanical / molecular mechanical method." Canadian Journal of Chemistry 90, no. 4 (2012): 376–83. http://dx.doi.org/10.1139/v2012-007.

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The organophosphorous compound tabun is highly neurotoxic because of its irreversible inhibition on acetylcholinesterase (AChE). It is wildly used as a warfare agent in the military. In this work, the aging and reactivation mechanism of tabun-inhibited AChE were studied by using the quantum mechanical / molecular mechanical (QM/MM) method. Geometry optimization of the stationary points were performed at the B3LYP/6–31G(d) level. Single-point energies were computed at the B3LYP/6–311++G(d,p) level. On the basis of the QM/MM results, a conclusion that the C–O bond scission is caused by water att

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16

Rücker, Nadine, Sandra Billig, René Bücker, Dieter Jahn, Christoph Wittmann, and Franz-Christoph Bange. "Acetate Dissimilation and Assimilation in Mycobacterium tuberculosis Depend on Carbon Availability." Journal of Bacteriology 197, no. 19 (2015): 3182–90. http://dx.doi.org/10.1128/jb.00259-15.

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ABSTRACTMycobacterium tuberculosispersists inside granulomas in the human lung. Analysis of the metabolic composition of granulomas from guinea pigs revealed that one of the organic acids accumulating in the course of infection is acetate (B. S. Somashekar, A. G. Amin, C. D. Rithner, J. Troudt, R. Basaraba, A. Izzo, D. C. Crick, and D. Chatterjee, J Proteome Res 10:4186–4195, 2011, doi:http://dx.doi.org/10.1021/pr2003352), which might result either from metabolism of the pathogen or might be provided by the host itself. Our studies characterize a metabolic pathway by whichM. tuberculosisgenera

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17

Saleh, H. A., S. F. Abdel Rahman, M. A. Batt, and H. R. K. Ali. "Toxicological, Biochemical and Histological Studies on the Fall Armyworm, Spodoptera frugiperda Treated with Five Insecticides." Arab Journal for Plant Protection 42, no. 4 (2025): 489–96. https://doi.org/10.22268/ajpp-001280.

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Saleh, H.A., S.F. Abd El-Rahman, M.A. Batt and H.R.K. Ali. 2024. Toxicological, Biochemical and Histological Studies on the Fall Armyworm, Spodoptera frugiperda Treated with Five Insecticides. Arab Journal of Plant Protection, 42(4): 489-496. https://doi.org/10.22268/AJPP-001280 Fall armyworm (FAW), Spodoptera frugiperda (J. E. Smith) is one of the most important, invasive, and destructive pests. It was reported for the first time on maize plants in 2019 in upper Egypt. A bioassay was conducted to evaluate the toxicity of 5 insecticides (Protecto 9.4% WP, Pesover 90% SP, Punkron 20% EC, Uphold

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18

Janeide, Maia Campelo. "Que faut-il didactiser? L'internet comme terrain d'apprentissage authentique et autonome dans les séances en ligne." Revista Letras Raras 11, Spécial (2023): 80–98. https://doi.org/10.5281/zenodo.8103352.

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La crise sanitaire de 2019 a poussé enseignants et élèves vers une nouvelle réalité pédagogique. Écartés de l’espace de la salle de classe, l’écran de nos ordinateurs et smartphones est devenu le principal outil d’enseignement. Les manuels utilisés en salle de classe physique, basés sur des activités en groupe ou dont la réalisation demandait l’aide de l’enseignant, n’ont pas répondu aux difficultés propres à ce nouveau contexte de travail. Le beso

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19

Smith, Francine G., Suzanne Chan, and Saskia N. De Wildt. "Effects of renal denervation on cardiovascular and renal responses to ACE inhibition in conscious lambs." Journal of Applied Physiology 83, no. 2 (1997): 414–19. http://dx.doi.org/10.1152/jappl.1997.83.2.414.

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Smith, Francine G., Suzanne Chan, and Saskia N. De Wildt.Effects of renal denervation on cardiovascular and renal responses to ACE inhibition in conscious lambs. J. Appl. Physiol. 83(2): 414–419, 1997.—Cardiovascular and renal effects of either the angiotensin-converting enzyme inhibitor captopril or vehicle were measured in chronically instrumented lambs in the presence (intact; n = 6) and absence of renal sympathetic nerves (denervated; n = 5) to determine whether there was an interaction between the renin-angiotensin system and renal sympathetic nerves early in life. Captopril caused a simi

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Sachdev, Robert N. S., Shao-Ming Lu, Ron G. Wiley, and Ford F. Ebner. "Role of the Basal Forebrain Cholinergic Projection in Somatosensory Cortical Plasticity." Journal of Neurophysiology 79, no. 6 (1998): 3216–28. http://dx.doi.org/10.1152/jn.1998.79.6.3216.

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Sachdev, Robert N. S., Shao-Ming Lu, Ron G. Wiley, and Ford F. Ebner. Role of the basal forebrain cholinergic projection in somatosensory cortical plasticity. J. Neurophysiol. 79: 3216–3228, 1998. Trimming all but two whiskers in adult rats produces a predictable change in cortical cell-evoked responses characterized by increased responsiveness to the two intact whiskers and decreased responsiveness to the trimmed whiskers. This type of synaptic plasticity in rat somatic sensory cortex, called “whisker pairing plasticity,” first appears in cells above and below the layer IV barrels. These are

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Lopes, Kelvin Saldanha, Francisco Willyego Holanda Maciel, Roque Soares Martins Neto, Vilana Maria Adriano Araújo, Juscelino de Freitas Jardim, and Mardonio Rodrigues Pinto. "Aplicações e possibilidades terapêuticas do uso do biomaterial quitosana para a odontologia: revisão de literatura." ARCHIVES OF HEALTH INVESTIGATION 9, no. 6 (2020): 587–91. http://dx.doi.org/10.21270/archi.v9i6.4782.

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A quitosana, polissacarídeo linear obtido a partir do exoesqueleto de crustáceos e artrópodes, tem sido pesquisada em Odontologia por suas diversas propriedades terapêuticas. O objetivo do presente estudo foi realizar uma revisão da literatura sobre as aplicações atuais e as possibilidades terapêuticas da quitosana na odontologia. A busca foi realizada através do banco de dados eletrônico do Pubmed, utilizando os descritores Quitosana, Odontologia e Biomateriais. Foram incluídas pesquisas científicas utilizando quitosana em diversas áreas da odontologia e excluídas revisões de literatura e est

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Yee, Andrew J., Jacob P. Laubach, Ajay K. Nooka, et al. "Phase 1 Dose-Escalation Study of Sotatercept (ACE-011) in Combination with Lenalidomide and Dexamethasone in Patients with Relapsed and/or Refractory Multiple Myeloma." Blood 126, no. 23 (2015): 4241. http://dx.doi.org/10.1182/blood.v126.23.4241.4241.

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Abstract Introduction Anemia and bone disease are hallmarks of multiple myeloma (MM). Sotatercept (ACE-011) is a novel, first-in-class activin type IIA receptor fusion protein that binds with high affinity to activin A and GDF11, and it acts during late-stage erythropoiesis to increase the production of mature erythrocytes through a mechanism independent of erythropoietin. Sotatercept has shown promising activity in clinical trials for anemia in myelodysplastic syndromes (Komrokji et al., ASH 2014) and in thalassemia (Cappellini et al., EHA 2015). Additionally, we have shown that targeting act

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23

Petrova, I. "IDENTIFICATION OF METAMODERNISM AS A CULTURAL PRACTICE." Bulletin of Mariupol State University. Series: Philosophy, culture studies, sociology 10, no. 20 (2020): 67–77. http://dx.doi.org/10.34079/2226-2830-2020-10-20-67-77.

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The article attempts to reveal the features of cultural practices of the metamodern era, to identify their fundamental features; to substantiate the peculiarities of human participation and empathy in the cultural process of modernity. The purpose of the scientific research was to describe the essence and analysis of the structure of metamodernism as a modern trend in the context of cultural practices. The basis for the methodology of the scientific study was the culturological approach, which allowed to substantiate the intertextuality of modern cultural practices in the context of metamodern

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24

Munish, Ahlawat, and Kumar Gautam Prashant. "IMPLICATION OF SLOW FOOD MOVEMENT ON CIRCULAR ECONOMY AND ECONOMIC SUSTAINABILITY." Manager - The British Journal of Administrative Management 57, no. 145 (2021): 169–79. https://doi.org/10.5281/zenodo.5990993.

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<strong>ABSTRACT</strong> The Slow Food movement was initiated with the aim of promoting local traditional food against the unhealthy fast food habit of the present times. However, gradually, the movement has involved itself with broader aspects of life as well. The movement has eventually protected the native entrepreneurs from the global corporate giants and their gradual economic aggression. In addition, with the help of the renewable policies for waste management, use of the biofuels, school garden network and the use of the green packaging, the Slow Food movement has also been able to cre

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Kolesnikova, I. A. "Post-pedagogical Syndrome of the Digimodernism Age." Vysshee Obrazovanie v Rossii = Higher Education in Russia 28, no. 8-9 (2019): 67–82. http://dx.doi.org/10.31992/0869-3617-2019-28-8-9-67-82.

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The article discusses the influence of Metamodern culture and digitalization of education on the transformation of the pedagogical understanding of learning process. The author relies on the post-postmodern age interpretations presented in the works of S. Abramson, M. Epstein, R. Eschelman, A. Kirby, J. Mensch, P. Samuels, L. Turner, T. Vermeulen and R. Van den Acker; the transdisciplinary (B. Nicholescu) and connectivist (D. Cormier, G. Siemens) approaches and international documents about the education development in a complex society. In the Metamodern epoch under the influence of the unive

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Cappellini, Maria-Domenica, John Porter, Raffaella Origa та ін. "A Phase 2a, Open-Label, Dose-Finding Study To Determine The Safety and Tolerability Of Sotatercept (ACE-011) In Adults With Beta (β)-Thalassemia: Interim Results". Blood 122, № 21 (2013): 3448. http://dx.doi.org/10.1182/blood.v122.21.3448.3448.

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Abstract Background Beta (β)-thalassemia is characterized by ineffective erythropoiesis leading to anemia, bone marrow erythroid hyperplasia, iron overload, and organ failure. Sotatercept (ACE-011) is a novel and first-in-class activin type IIA receptor (ActRIIA) fusion protein that increases the release of mature erythrocytes into circulation by acting mainly on late-stage erythropoiesis (Carrancio S, et al. Blood. 2012;120:abstract 372). Clinical data in healthy volunteers have shown that treatment with sotatercept results in increased red blood cell (RBC) parameters, including hemoglobin le

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Flück, Martin, Grégoire Mercier, Silvio Lorenzetti, and Marie-Noëlle Giraud. "Activation of the erythropoietin system in exhaustively exercise muscle relates to ACE gene polymorphism-modulated metabolic signalling and mitochondrial transcript expression." Current Issues in Sport Science (CISS) 9, no. 2 (2024): 042. http://dx.doi.org/10.36950/2024.2ciss042.

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Introduction Introduction A fall in muscle oxygen saturation is a potent activator of mitochondrial biogenesis in exercised skeletal muscle which is subject to the training-modulated influence of the insertion/deletion polymorphism of the angiotensin converting enzyme gene (ACE-I/D; Gasser et al 2022) and may involve paracrine erythropoietin (EPO) signaling (Desplanches et al 2014, Nijholt et al 2021). We tested the hypothesis that erythropoietin expression and signaling in fatiguingly exercised muscle would correspond to the expression of hypoxia-regulated mitochondrial genes and altere

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Bose, Prithviraj, Naval Daver, Elias J. Jabbour, et al. "Phase-2 Study of Sotatercept (ACE-011) in Myeloproliferative Neoplasm-Associated Myelofibrosis and Anemia." Blood 128, no. 22 (2016): 478. http://dx.doi.org/10.1182/blood.v128.22.478.478.

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Abstract Introduction: Anemia is common in MPN-associated myelofibrosis (MF), and current therapies (e.g., erythropoiesis stimulating agents, androgens, danazol, immune modulatory drugs and corticosteroids) are unsatisfactory. Furthermore, anemia is not improved and initially worsened by ruxolitinib, an important MF therapy. New drugs with novel mechanisms of action are needed. Sotatercept is a first-in-class activin receptor type IIA (ActRIIA) ligand trap consisting of the extracellular domain of ActIIRA linked to the human IgG1 Fc domain. Sotatercept binds to and sequesters ligands of the tr

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Alzahrani, Noor Ahmed, Khulud Abdullah Bahaidrah, Rasha A. Mansouri, Rahaf Saeed Aldhahri, Gamal S. Abd El-Aziz, and Badrah S. Alghamdi. "Possible Prophylactic Effects of Sulforaphane on LPS-Induced Recognition Memory Impairment Mediated by Regulating Oxidative Stress and Neuroinflammatory Proteins in the Prefrontal Cortex Region of the Brain." Biomedicines 12, no. 5 (2024): 1107. http://dx.doi.org/10.3390/biomedicines12051107.

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Background: Alzheimer’s disease (AD) presents a significant global health concern, characterized by neurodegeneration and cognitive decline. Neuroinflammation is a crucial factor in AD development and progression, yet effective pharmacotherapy remains elusive. Sulforaphane (SFN), derived from cruciferous vegetables and mainly from broccoli, has shown a promising effect via in vitro and in vivo studies as a potential treatment for AD. This study aims to investigate the possible prophylactic mechanisms of SFN against prefrontal cortex (PFC)-related recognition memory impairment induced by lipopo

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Platzbecker, Uwe, Ulrich Germing, Aristoteles Giagounidis, et al. "ACE-536 Increases Hemoglobin and Reduces Transfusion Burden in Patients with Low or Intermediate-1 Risk Myelodysplastic Syndromes (MDS): Preliminary Results from a Phase 2 Study." Blood 124, no. 21 (2014): 411. http://dx.doi.org/10.1182/blood.v124.21.411.411.

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Abstract Introduction. ACE-536, a recombinant fusion protein containing modified activin receptor type IIB and IgG Fc, is being developed for the treatment of anemias due to ineffective erythropoiesis, such as myelodysplastic syndromes (MDS). Patients with MDS often have elevated levels of erythropoietin (EPO) and may be non-responsive or refractory to erythropoiesis-stimulating agents (ESAs). MDS patients have also been shown to have increased serum GDF11 levels (Suragani R et al., Nature Medicine 2014) and increased Smad 2/3 signaling in the bone marrow (Zhou L et al., Blood 2008). ACE-536 b

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Piga, Antonio G., Silverio Perrotta, Angela Melpignano, et al. "ACE-536 Increases Hemoglobin and Decreases Transfusion Burden and Serum Ferritin in Adults with Beta-Thalassemia: Preliminary Results from a Phase 2 Study." Blood 124, no. 21 (2014): 53. http://dx.doi.org/10.1182/blood.v124.21.53.53.

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Abstract Introduction. ACE-536, a recombinant fusion protein containing modified activin receptor type IIB and IgG Fc, is being developed for the treatment of anemias due to ineffective erythropoiesis (IE), such as beta-thalassemia (β-thal). In β-thal, IE is due to intracellular α-globin aggregates causing premature death of late-stage erythroid precursors. Patients with β-thal often have elevated levels of EPO and are unresponsive to erythropoiesis-stimulating agents (ESAs). ACE-536 binds to ligands in the TGF-β superfamily, such as GDF11, and promotes late-stage erythroid differentiation via

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Komrokji, Rami S., Guillermo Garcia-Manero, Lionel Ades, et al. "An Open-Label, Phase 2, Dose-Finding Study of Sotatercept (ACE-011) in Patients with Low or Intermediate-1 (Int-1)-Risk Myelodysplastic Syndromes (MDS) or Non-Proliferative Chronic Myelomonocytic Leukemia (CMML) and Anemia Requiring Transfusion." Blood 124, no. 21 (2014): 3251. http://dx.doi.org/10.1182/blood.v124.21.3251.3251.

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Abstract Introduction: Anemia, a hallmark of MDS, is challenging to treat, particularly after failure of erythropoiesis-stimulating agents (ESAs). Sotatercept (ACE-011) is a novel and first-in-class activin type IIA receptor fusion protein that acts on late-stage erythropoiesis to increase mature erythrocyte release into the circulation (Carrancio et al. Br J Haematol 2014;165:870-82). Treatment with sotatercept stimulated erythropoiesis and significantly increased hemoglobin (Hb) levels in healthy volunteers (Sherman et al. J Clin Pharmacol 2013;53:1121-30), supporting its clinical developmen

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Eddine, Laib Djamel, Benzehra Abdelmadjid, Rahmani Youcef, Boulaouad Belkacem Aimene, and Akkal Salah. "L’emploi de l’extrait du champignon endophyte Aspergillus niger isolé à partir des feuilles du ricin commun Ricinus communis L. (Euphorbiaceae, Malpighiales) comme agent de lutte biologique contre le criquet migrateur Locusta migratoria L. (Oedipodinae, Acrididae)." Journal of Applied Biosciences 170 (February 28, 2022): 17720–38. http://dx.doi.org/10.35759/jabs.170.5.

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Objectifs : Évaluer l'activité insecticide de l'extrait du champignon endophyte Aspergillus niger. Méthodologie et Résultats : Pour évaluer l'activité insecticide, dix concentrations (de 0,2 à 2 g/ L) de l'extrait fongique ont été appliqués par contact et par ingestion contre Locusta migratoria L. Pour connaitre la nature des métabolites secondaires responsables de l’activité insecticide des analyses chimiques, infrarouge à réflexion totale atténuée par transformée de Fourier de l'extrait fongique et un GC-MS-MS des hyphes du champignon et de l'extrait fongique ont été effectués. Un test d’inh

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Leerling, A., F. Smit, Z. Späth, et al. "AB1455 FLUORIDE UPTAKE ON QUANTITATIVE POSITRON EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY (NA18F-PET/CT) AS NOVEL BIOMARKER FOR DISEASE ACTIVITY IN ADULT CHRONIC NONBACTERIAL OSTEOMYELITIS/SYNOVITIS ACNE PUSTULOSIS HYPEROSTOSIS OSTEITIS SYNDROME (CNO/SAPHO)." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1955.3–1955. http://dx.doi.org/10.1136/annrheumdis-2023-eular.987.

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BackgroundChronic nonbacterial osteomyelitis (CNO) is a rare bone disease characterized by sterile bone inflammation and locally increased bone turnover. CNO that occurs in the rheumatic spectrum of synovitis, acne, pustulosis, hyperostosis and osteitis is referred to as SAPHO syndrome [1, 2]. To date, there are no objective biomarkers for monitoring disease activity. Recommended imaging tools like technetium radiolabeled hydroxymethylene diphosphonate single positron emission computed tomography visualize the increased bone turnover, but fail to reflect the relapsing-remitting disease activit

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Traub, Hartmut. "J. G. Fichte." Fichte-Studien 40 (2012): 9–28. http://dx.doi.org/10.5840/fichte20124020.

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Traub, Hartmut. "J. G. Fichte." Fichte-Studien 7 (1995): 199–212. http://dx.doi.org/10.5840/fichte1995710.

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Vrebos, Jacques, and Christian Dupuis. "J. G. Hierzel." Plastic and Reconstructive Surgery 93, no. 1 (1994): 201–4. http://dx.doi.org/10.1097/00006534-199401000-00034.

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M., L. Sanyasi Rao, and Varma Y.N.R. "FOLKLORE TRADITIONAL KNOWLEDGE ON DIGESTIVE DISORDERS OF DOMESTIC ANIMALS (CATTLE, SHEEP AND GOATS) IN THE MEDAK DISTRICT, TELANGANA, INDIA." Biolife 2, no. 3 (2022): 858–65. https://doi.org/10.5281/zenodo.7220622.

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<strong>ABSTRACT</strong> The paper deals with exploration of folklore knowledge on medicinal plants used in digestive disorders of livestock (cattle, sheep and goats) practiced by local healers of Medak district, Telangana, India.  An attempt is made to gather information from the local pastoral healers belonging to Golla, Kurma,Lambada, Mudiraj and Gouda communities. The author has interviewed 25 healers and recorded the methods of collection of herbal plants and methods of preparation of the drugs used by them. Livestock of the district are commonly prone to digestive disorders like an

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임금희. "Cosmopolitanism, Nationalism, Language in J. G. Herder & J. G. Fichte." PHILOSOPHY·THOUGHT·CULTURE ll, no. 20 (2015): 119–48. http://dx.doi.org/10.33639/ptc.2015..20.002.

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Mehta, Varshil, Kavya Bhatt, Nimit Desai, and Mansi Naik. "Probiotics: An Adjuvant therapy for D-Galactose induced Alzheimer's disease." Journal of Medical Research and Innovation 1, no. 1 (2017): 30–33. https://doi.org/10.5281/zenodo.345753.

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<strong>Abstract</strong> Alzheimer's disease (AD) is a chronic and slowly progressing neurodegenerative disorder which has become a major health concern worldwide. The literature has shown that oxidative stress is one of the most important risk factors behind the cause of AD. Oxidative stress often leads to the production of Reactive Oxygen Species (ROS). D-Galactose, a physiological nutrient and reducing sugar, non-enzymatically reacts with amines of amino acids in proteins and peptides to form Advanced Glycation End products which activate its receptors coupled to Biochemical pathways that

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Kastner, D. "J.-G. OLIGMÜLLER. Streifzüge." Annalen des Historischen Vereins für den Niederrhein 192-193, jg (1990): 263. http://dx.doi.org/10.7788/annalen-1990-jg59.

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Fincher, Ruth, Michael Webber, Brian Finlayson, and Alaric Maude. "G J (Geoff) Missen." Geographical Research 58, no. 2 (2020): 201–2. http://dx.doi.org/10.1111/1745-5871.12403.

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Lyman, Charles. "Henry G. J. Moseley." Microscopy Today 22, no. 4 (2014): 7. http://dx.doi.org/10.1017/s1551929514000662.

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Sasikala, D., and A. J. Divya. "J-G-BICONTINUOUS, J-G-BI-IRRESOLUTE IN COMPLEMENTED DITOPOLOGICAL TEXTURE SPACES." Advances in Mathematics: Scientific Journal 9, no. 10 (2020): 8815–25. http://dx.doi.org/10.37418/amsj.9.10.105.

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Poviliūnas, Arūnas. "J. G. Fichtės filosofijos tyrimas." Problemos 39 (September 29, 2014): 129–30. http://dx.doi.org/10.15388/problemos.1988.39.7161.

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1986 m. lapkričio 18 d. Vilniaus universitete Saulius Arlauskas apgynė filosofijos kandidato disertaciją „Valios ir juslumo vienybės problema J. G. Fichtės filosofijoje“. Mokslinis vadovas – prof. B. Genzelis, oficialieji oponentai: prof. J. Minkevičius ir prof. A. Šliogeris. Disertacijoje atskleidžiamos istorinės ir loginės J. G. Fichtės filosofijos ištakos, jo filosofavimo principai įvertinami iš marksistinės-lenininės filosofijos pozicijų, patikslinami kriterijai, kuriais remiantis vertinamas valios ir juslumo sąvokų santykis.

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Schottky, Richard. "J. G. Fichte im Gesprach." Fichte-Studien 5 (1993): 219–24. http://dx.doi.org/10.5840/fichte1993517.

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Franco Bonifaz, Nazahed. "Sonette / Sonetos, J. G. Fichte." Thémata Revista de Filosofía, no. 63 (2021): 403–6. http://dx.doi.org/10.12795/themata.2021.i63.20.

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Dubor, Francoise. "J. M. G. Le Clezio." Yale French Studies, no. 75 (1988): 209. http://dx.doi.org/10.2307/2929371.

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Schnell, Alexander. "J. G. Fichte 1804-1805." Archives de Philosophie 72, no. 3 (2009): 403. http://dx.doi.org/10.3917/aphi.723.0403.

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Henk, J. M. "Professor H. J. G. Bloom." Clinical Radiology 40, no. 4 (1989): 440. http://dx.doi.org/10.1016/s0009-9260(89)80173-4.

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