To see the other types of publications on this topic, follow the link: JANNuS.
Dissertations / Theses on the topic 'JANNuS'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 dissertations / theses for your research on the topic 'JANNuS.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.
1
Brimbal, Daniel. "Evolution microstructurale du fer pur et d’un alliage Fe-Cr sous irradiation avec injection simultanée d’hélium : étude expérimentale et modélisation." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA112278.
Full textAbstract:
Les aciers ferrito-martensitiques sont d’excellents candidats potentiels en tant que matériaux de structure dans les futurs réacteurs de fusion. A ce titre, ils devront résister à des flux intenses de neutrons de 14 MeV qui créeront des cascades de déplacements atomiques et des produits de transmutation tels que l’hélium. Afin de mieux comprendre le comportement de base de ces aciers sous irradiation en présence d’hélium, nous avons étudié les effets de l’hélium et ceux du chrome dans le cadre de ce travail de thèse. Du fer pur et un alliage modèle Fe-5,4%pds Cr ont ainsi été irradiés dans la plateforme JANNuS à 500°C en bi-faisceau avec des ions Fe+ et He+ et en mono-faisceau avec des ions Fe+. L’utilisation de cette plateforme a permis de suivre l’évolution du dommage jusqu’à des doses faibles (1 dpa) et de caractériser la microstructure après irradiation à forte dose (100 dpa). Elle a également permis l’observation in situ dans un MET couplé à deux accélérateurs des effets cinétiques d’implantation/irradiation. La nature et la répartition des défauts d’irradiation ont été déterminés : ce sont essentiellement des boucles de dislocations de vecteur de Burgers de type a<100> et des cavités/bulles. Nous avons montré que la co-implantation d’hélium et l’addition de chrome réduisent la mobilité des boucles. Par ailleurs, avec ou sans hélium, l’addition de chrome réduit le gonflement dans toutes les conditions étudiées. De plus, dans le fer pur irradié avec hélium, un phénomène original de germination hétérogène de cavités/bulles dans les plans des boucles a été mis en évidence. Enfin, nous avons également utilisé le code de dynamique d’amas CRESCENDO pour interpréter les résultats expérimentaux dans le fer pur irradié avec héliumFerritic-martensitic steels are excellent potential candidates for a use as structural materials in future fusion reactors. For this application, they will have to withstand high fluxes of 14 MeV neutrons that will create atomic displacement cascades and transmutation reactions which will produce large quantities of helium. In order to understand the basic mechanisms under irradiation with helium, we have studied the effects of helium and those of chromium. Pure iron and a Fe-5.4 wt. % Cr model alloy were irradiated at the JANNuS platform in dual-beam mode with Fe+ and He+ ions and in single-beam mode with Fe+ ions at 500ºC. This platform enabled us to follow the evolution of damage up to low doses (1 dpa) and to characterize the microstructure at high doses (100 dpa). It also allowed us to observe in situ irradiation/implantation kinetic effects in a TEM coupled to two accelerators. The nature and distribution of irradiation defects was determined: they are essentially dislocation loops with a<100> Burgers vectors and cavities/bubbles. We have demonstrated that the co-implantation of helium and the addition of chromium both reduce the mobility of dislocation loops. The addition of chromium reduces swelling for all the irradiation conditions studied, with or without helium. In pure iron irradiated with helium, an original phenomenon was discovered for the first time: cavities/bubbles nucleate heterogeneously on the planes of the dislocation loops. We have also interpreted our experimental results in pure iron irradiated with helium using the cluster dynamics code CRESCENDO
2
Drube, Fabian. "Selfdiffusiophoretic Janus colloids." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-173348.
Full text
3
França, Junior Edegar. "The multifaced janus." Florianópolis, SC, 2008. http://repositorio.ufsc.br/handle/123456789/103220.
Full textAbstract:
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão. Programa de Pós-graduação em Letras/Inglês e Literatura CorrespondenteMade available in DSpace on 2013-07-16T03:38:01Z (GMT). No. of bitstreams: 1 252106.pdf: 267336 bytes, checksum: 0c5801e1d015f9b4000f0ff98d6425fc (MD5)
As many countries, Canada has been built by the hands of immigrants. The great amount of people who have been looking for a better life in Canada made it a country of many cultures. On the one hand, the nation has been presented as land of opportunities. On the other hand, a reality of prejudice and discrimination overshadows an all-embracing nation. In order to regulate the immigrants' situation in the country, the Canadian Multiculturalism Act was instituted to guarantee equal rights and freedom to all cultures, besides preserving and enhancing multiculturalism in Canada. Many immigrant writers have been writing about immigration and the implications of multiculturalism. Many critics, theorists and writers support these policies while others severely criticize them. Interestingly, the works of the Asian-Caribbean writer Cyril Dabydeen have been read both as a celebration and a criticism to themes related to immigrants' issues. Dabydeen depicts himself as a Janus-faced person, someone who feels the need of looking in different directions. Janus represents the contemplation of past happenings while looking towards the future. In this work, I will analyze Dabydeen's poetry in dialogue with his prose works in order to demonstrate the development of his craft as writer. In his early works, he used to make a direct criticism the issues of immigration, as it can be observed in the poems "Lady Icarus" and "Señorita." Dabydeen's more recent works are full of historical references and use of language in a way that may allow both a celebration to multiculturalism and a criticism to the policies regulated by the dominant culture, as in "Multiculturalism." Como muitos países, o Canadá foi construído pelas mãos de imigrantes. O grande número de pessoas que procuraram e continuam a procurar uma vida melhor no Canadá fez desse um país de muitas culturas. Se, por um lado, o país tem-se apresentado como uma terra de oportunidades, por outro lado, uma realidade de preconceito e discriminação mancha essa nação que promete abraçar a diversidade. De forma a regulamentar a situação dos imigrantes no país, a Lei de Multiculturalismo do Canadá foi aprovada para garantir igualdade de direitos e de liberdade a todas as culturas, além de preservar e fomentar o multiculturalismo. Muitos escritores imigrantes têm escrito sobre imigração e sobre as implicações do multiculturalismo. Muitos críticos, teóricos e escritores apóiam essas políticas enquanto outros severamente criticam-nas. De forma intrigante, os trabalhos do escritor asiático-caribenho Cyril Dabydeen têm sido lidos tanto como celebração bem como crítica aos temas relacionados às políticas de imigração. Dabydeen descreve a si mesmo como uma pessoa com face de Janus, alguém que sente a necessidade de olhar em diferentes direções. Janus representa a contemplação de eventos passados ao mesmo tempo em que olha em direção ao futuro. Neste trabalho, eu analiso a poesia de Dabydeen, em diálogo com seus trabalhos em prosa, para demonstrar o desenvolvimento de sua arte enquanto escritor e poeta. Em seus primeiros trabalhos, ele fazia um ataque aberto às políticas de imigração e perseguição aos imigrantes, como se pode ler nos poemas "Lady Icarus" e em "Señorita." Os trabalhos mais recentes de Dabydeen são repletos de referências histórias a eventos obscuros contra imigrantes no Canadá. Essas referências, e o uso de linguagem que permite mais de uma interpretação fazem com que alguns de seus trabalhos sejam lidos tanto como celebração em relação ao fenômeno do multiculturalismo como crítica às leis implementadas pela cultura dominante, como pode ser lido no poema "Multiculturalismo."
4
Georgiou, Aphrodite. "Die Dimension der Vergangenheit im Werk von Jannis Kounellis /." Köln, 1998. http://catalogue.bnf.fr/ark:/12148/cb39126411d.
Full text
5
Etges, Christine Bareño. "A janus-faced manipulation." Florianópolis, SC, 2000. http://repositorio.ufsc.br/xmlui/handle/123456789/78630.
Full textAbstract:
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão. Programa de Pós-Graduação em Letras/Inglês e Literatura Correspondente.Made available in DSpace on 2012-10-17T17:05:36Z (GMT). No. of bitstreams: 0Bitstream added on 2014-09-25T18:06:04Z : No. of bitstreams: 1 180336.pdf: 13110443 bytes, checksum: 32e936b37dbff242433d7aa86a541c71 (MD5)
Narrativas de viagem são especialmente interessantes em tradução uma vez que seus autores já 'traduziram' a realidade do país que visitaram, tanto literalmente quanto figurativamente. O tradutor tem, então, a desafiadora tarefa de traduzir o traduzido. Quando acontece de o tradutor ser um nativo do país visitado, a tarefa torna-se ainda mais complexa, pois ele está retornando a seu contexto nacional uma perspectiva construída a partir de olhos estrangeiros. Este trabalho investiga uma dessas narrativas de viagem entitulada 'The world is burning - murder in the rain forest' (Alex Shoumatoff, 1990) e sua tradução 'O mundo em chamas - a devastação da Amazônia e a tragédia de Chico Mendes'. A metodologia adotada consiste em uma investigação descritiva do texto traduzido a fim de identificar os shifts (mudanças) em relação ao texto original, seguindo o modelo adotado por Kitty van Leuven-Zwart (1989,1990). As unidades de tradução são analisadas olhando-se os shifts que ocorrem em áreas como: escolha de itens lexicais individuais, transitividade, modalidade e estrutura temática (ordem de palavras). A análise move-se, então, para descrever como, através de 'shifts' na narrativa, a tradução brasileira reescreve a relação entre narrador / leitor e a imagem construída da Amazônia.
6
Kirillova, Alina. "Stimuli-Responsive Janus Particles." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-201847.
Full textAbstract:
Janus particles, named after the two faced Roman god Janus, possess unique asymmetry and combine two distinct functions at their opposite sides, allowing them to target complex self-assembled architectures and materials inaccessible for homogeneous building blocks. In this study, three areas regarding the topic of Janus particles were explored: the synthesis of Janus particles, their (self-) assembly, and applications.
In the first part of the work, we have drawn our attention to the optimization of the synthetic procedures concerning the preparation of Janus particles and to the extending of the current Janus particle library by adding new geometries to the list. In the case of spherical Janus particles, we have developed an easy approach to tailor the Janus ratio of the resulting particles, thus, extending the possibilities of the Pickering emulsion approach for the creation of a variety of Janus particle architectures. Additionally, a new methodology was employed to measure directly and in situ the position/contact angle of the prepared Janus particles with different Janus ratios at a water-oil interface. It was further concluded that having simply two different functionalities on a particle surface does not necessarily imply amphiphilic behavior: only in the case of large wettability contrasts our particles were in a true Janus regime. In the case of platelet-like Janus particles, we have developed a completely new approach for their large-scale synthesis, which involved a reduced number of steps compared to the spherical Janus particles.
In the second part of the work, the assembly behavior of various kinds of functional spherical Janus particles was investigated depending on the nature of the Janus particles and the surrounding media conditions. Oppositely charged, uncharged amphiphilic, and charged amphiphilic Janus particles were fabricated comprising different responsive polymers on their surface, and their assembly was investigated depending on the pH value of the dispersion, the ionic strength, or the solvent. It was found that, under specific conditions, the Janus particles formed hierarchical chain-like structures in solutions, which were not observed in the case of the homogeneous particle mixtures. The obtained results indicate that the fundamental understanding of the Janus particle assembly mechanisms is crucial for the programmed formation of desired structures.
In the third part of the work, we have focused on the applications of our developed hybrid hairy Janus particles and proposed two main directions that would benefit from the unique properties or architecture of the Janus particles. The first direction is based on the exploitation of the superior interfacial activity of the Janus particles and their use for interfacial catalysis. The second proposed direction for the application of Janus particles is based on their use as building blocks for functional structured surfaces. The prepared surfaces were thoroughly characterized and tested for their performance toward anti-icing as well as anti-fouling applications. Ultimately, the developed functional surfaces based on Janus particles as building blocks are very promising for their future application in the coating technology.
7
Castro, Nicolò. "Auto-assemblage de nanoparticules Janus." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS486/document.
Full textAbstract:
L’expression "Nanoparticules Janus" est utilisée pour se référer aux nanoparticules colloïdales faites de deux moitiés qui présent deux propriétés physiques et/ou chimiques différentes. Au cours des dernières années, plusieurs études théoriques ont été publiées sur les possibilités d’auto-assemblage offertes par ces particules (en particulier par Sciortino, F. et al.), mais peu de travail expérimental a été fait sur ce sujet. Les études théoriques suggèrent que beaucoup de comportements intéressants apparaissent quand la taille des particules s’approche de la portée d’interaction des forces en jeu (des dizaines de nanomètres dans le cas des forces de Van der Waals et des forces hydrophobes). Dans ce manuscrit, nous montrons la formation d’agrégats des hétérodimères de Au–SiO₂ d’une taille inférieure à 100nm. L’auto-assemblage a été déclenché par un échange du ligand hydrophile sur la surface de l’or par un ligand hydrophobe induisant une interaction attractive. L’assemblage a été suivi par spectroscopie d’absorption résolue dans le temps et diffusion des rayons X aux petits angles. Nous avons constaté que les thiols les plus courts ont une période d’induction plus longue et forcent les particules à se rapprocher davantage, comparé à des thiols avec des chaînes plus longues. Nous étudions également un second système : des nanoplaquettes de CdSe. Celles-ci sont des objets quasi-2D en matériau semiconducteur avec des propriétés optiques uniques. Ces propriétés résultant de leur taille réduite dans une dimension. Du fait de leur nouveauté et de leur particularité, leur nucléation et le remarquable mécanisme de croissance de ces particules sont toujours étudiés. Ainsi nous avons suivi leur synthèse par SAXS et WAXS in situ, afin d’obtenir des informations en ce qui concerne ces deux étapes, et notamment d’étudier la déformation de certains de ces systèmes sous forme de feuillets enroulés de CdSe. Les nanoplaquettes de CdSe ont été aussi utilisés pour créer des structures hybrides CdSe–Au. La combinaison de ces deux matériaux a déjà montré des effets uniques, comme une meilleure efficacité catalytique et, combiné avec la dimension réduite et le contrôle des plaquettes, pourrait aboutir à des caractéristiques encore plus intéressantes. Nous proposons une méthode de synthèse qui aboutit à la formation de petites sphères d’or sur les coins des plaquettes. Nous montrons que la taille des sphères dépend de la quantité de précurseur utilisée, et des images de microscopie électronique à haute résolution mettent en évidence la structure cristalline des deux matériaux"Janus nanoparticles" is the term used to refer to colloidal nanoparticles made of two halves with different physical and chemical properties. Over the last years, several theoretical studies have been published on the self-assembly possibilities offered by these particles (in particular by Sciortino, F. et al.), but little experimental work has been done on them. The theoretical studies suggest that many interesting behaviors appear when the size of the particles approaches the interaction range of the forces at play (tens of nanometers in the case of van der Waals and hydrophobic forces). In this manuscript, we show the formation of clusters of Au–SiO₂ heterodimers with sizes of less than 100nm. The self-assembly was induced by exchanging the hydrophilic ligand on the Au surface with a hydrophobic one, which provided the attractive interaction. The assembly was followed by time-resolved absorption spectroscopy and small-angle X-ray scattering. We found that shorter thiols have a longer induction period, and cause the particles to come closer together, compared to thiols with longer tails. We also study a second system: CdSe nanoplatelets. These are semiconducting quasi-2D structures with unique optical properties. These properties result from their reduced size in one of the dimensions. Because of their novelty and particularity, the nucleation and growth mechanism of these particles is still being studied. We followed the synthesis using in-situ SAXS and WAXS, to obtain information with regards to this mechanism and to study the deformation which occurs in some of these systems which leads to rolled up sheets of CdSe. The CdSe nanoplatelets were also used to create hybrid CdSe–Au structures. The combination of these two materials has already proven to produce unique effects such as enhanced catalysis and, combined with the reduced dimensionality and control of the platelets, could result in even more interesting characteristics. We propose a synthesis method which results in the formation of small gold spheres on the corners of the platelets. We show that the size of the spheres depends on the amount of precursor used, and show high resolution electron microscopy images which highlight the crystalline structure of both materials
8
Millart, Elodie. "Nanoparticules lipidiques de type Janus à compartiment superparamagnétique : du procédé de mise en oeuvre aux applications théranostiques." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS540/document.
Full textAbstract:
Depuis quelques années, notre laboratoire développe des nanoparticules lipidiques bicompartimentées originales produites par homogénéisation haute pression, un procédé transposable à grande échelle, à partir d’excipients pharmaceutiques validés par différentes pharmacopées (Eur., USP, JP). Ces particules appartiennent ainsi à la famille des nano-objets Janus puisqu’elles sont organisées en deux sous-structures juxtaposées : une moitié est constituée d’une gouttelette huileuse alors que l’autre moitié est composée d’une structure vésiculaire et renferme un cœur aqueux délimité par une bicouche phospholipidique. En plus de la biocompatibilité intrinsèque des lipides constituants, un tel système représente un outil potentiellement très intéressant et valorisable du point de vue pharmaceutique et biomédical capable d’incorporer séparément et de co-véhiculer des substances hydrophiles et lipophiles aux activités distinctes, par exemple un agent d’imagerie médical et un principe actif pour coupler diagnostique et thérapie. Ici, nous nous sommes intéressés à charger les nanoparticules Janus avec un fluide magnétique composé de nanocristaux d’oxyde de fer (ferrofluide, FF), actif en tant qu’agent de contraste efficace en IRM, étant magnétiquement contrôlable et permettant d’envisager un traitement par hyperthermie. Tour à tour, des FF hydrophiles ou lipophiles compatibles avec le procédé de production ont été développés en étudiant différentes voies de stabilisation des nanocristaux en fonction du compartiment d’encapsulationIn recent years, our team has developed original compartmented lipid nanometer-sized particles produced by high pressure homogenization, a scalable process, with pharmaceutically approved excipients. The particles actually belong to the family of Janus nano-objects as they are organized in two juxtaposed substructures : one half is a droplet of liquid-state lipids while the other half is vesicle-like and encloses an aqueous core delimited by a phospholipid-containing bilayer shell. Added to the intrinsic biocompatibility of the constituting lipids, such a system provides a potentially very valuable tool in pharmaceutical and biomedical fields, able to separately incorporate and co-convey hydrophilic and lipophilic substances with distinct activities, for example, a medical imaging agent and a drug for coupling diagnosis and therapy. Here, we are interested in loading Janus nanoparticles with a magnetic fluid composed of superparamagnetic iron oxide nanocrystals (ferrofluid, FF), indeed as efficient contrast agent for MRI, being magnetically targetable and providing ability for hyperthermia treatment. Alternately, hydrophilic or lipophilic FF compatible with the production process have been developed by investigating different stabilization pathways of the nanocrystals depending on the encapsulation compartment
9
Goldbach, Ines. "Wege aus der Arte Povera Jannis Kounellis im Kontext internationaler Kunstentwicklung." Berlin Gebr. Mann, 2008. http://d-nb.info/998994642/04.
Full text
10
Pearman, Gerald M. "Comparison study of Janus and JLINK." Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1997. http://handle.dtic.mil/100.2/ADA333412.
Full text
11
Ma, Tiantian. ""Janus" liquid crystals based on diphenylacetylene." Thesis, University of York, 2013. http://etheses.whiterose.ac.uk/5928/.
Full textAbstract:
Supermolecular architecture has the ability to control the fine property and location of specific functional groups which allows them to be applied in various advanced fields. One of the most intriguing aspects is the self-organisation of complex giant molecular systems, especially for the materials with diversely functionalised faces or sides, which can recognise from one side to another, also known as "Janus" materials. In this project, dendritic supermolecules with more than one type of LC at the periphery (Janus liquid crystals) were developed. These LC molecules have a rigid diphenylacetylene core to which the dendritic linking scaffolds for the periphery groups can be attached. With different LC phase inducing ability, both the end-on and side-on mesogenic units have been used to build the amphiphilic system. The polyphilic materials containing different types of aliphatic chains as end-groups, which can enhance microphase segregation in this family. Two types (1:3 and 3:3) of Janus liquid crystals with different ratios of peripheral moieties were synthesized, along with their liquid crystal properties being studied. The mesomorphic behaviour of the Janus LCs is determined by the type of the mesogenic units, the microphase segregation effect controlled by the aliphatic chains, and also the steric effect relevant to the central core and dendritic scaffold. The synergy and competition among these factors generated mesophase behaviours which are unique to this type of supermolecular LC system. A series of side-on functionalized monomeric mesogens, LC dimers and trimers, and LC multipedes which is the intermediate in the synthesis of Janus LCs, were all developed as contrasts to the Janus LCs, for the systematical study in the mesomorphic behavior. Several of the giant molecular LCs based on hexaphenylbenzenes were also obtained from the Janus LC and oligomers via alkyne trimerization. With the unusual molecular conformation and distribution of peripheral groups, they also have novel self-assembling behaviours. Along with the Janus LCs, the supermolecular LCs provided an elegant entry for understanding the connection between the nanoscale structure and the macroscopic physical properties.
12
Psilopoulos, Jannis [Verfasser]. "Ein Streuverfahren zur Charakterisierung kompositer Materialien / Jannis Psilopoulos." Aachen : Shaker, 2003. http://d-nb.info/1179037812/34.
Full text
13
Dietrich, Jannis P. [Verfasser]. "Augmented Reality-Umgebungen im Urheberrecht / Jannis P. Dietrich." Berlin : Humboldt-Universität zu Berlin, 2021. http://d-nb.info/1228333475/34.
Full text
14
Broscheit, Jannis [Verfasser]. "Rechtswirkungen von Genehmigungsfiktionen im Öffentlichen Recht. / Jannis Broscheit." Berlin : Duncker & Humblot, 2016. http://d-nb.info/1238438342/34.
Full text
15
Ayala, Hernández Abraham. "Janus-type and Molecular MOF-based composites." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/461179.
Full textAbstract:
La presente Tesis está enfocada al estudio, desarrollo e implementación de nuevas metodologías de síntesis de estructuras metal-orgánicas (MOFs) basadas en compuestos multifuncionales. El trabajo de investigación de esta Tesis se desarrolló en dos líneas de investigación: i) por un lado, la síntesis de partículas metálicas Janus con MOFs y su funcionalización parcial para aplicaciones en eliminación de metales pesados, aplicaciones de auto movilidad y fluorescencia, ii) por otro lado la incorporación de moléculas activas en MOFs a través de la creación controlada de defectos, estudiando la formación del MOF así como su posible aplicación en eliminación de metales pesados
En el capítulo uno, nosotros revisamos la evolución en el campo de los MOFs a partir de un desarrollo histórico, y la presentación de las principales estrategias de síntesis, así como las propiedades y aplicaciones. También, nosotros presentamos especial atención en las metodologías actuales para la miniaturización de MOFs, las mejoras en las propiedades y posibles aplicaciones. También mencionamos la importancia de las posibilidades de crear compuestos de MOF combinando las propiedades intrínsecas de MOFs y otros materiales funcionales, por ejemplo, materiales magnéticos, materiales fluorescentes y catalíticos.
En el capítulo dos, se describen los objetivos de la Tesis.
En el tercer capítulo, se presenta el trabajo llevado a cabo en la síntesis de partículas de tipo Janus basados en MOFs. Una vez introducidos los conceptos de partículas de tipo Janus y la manera de sintetizados se presenta el trabajo experimental llevado a cabo. Este trabajo se basa en la evaporación controlada y selectiva de metales sobre parte de la superficie de MOFs. Esta metodología novedosa se organiza en diferentes pasos: i) Síntesis de MOFs nanoscópicos de tamaño controlado, ii) Deposición controlada en superficie de una monocapa de nanocristales de MOF dispersos, iii) Evaporación sobre las monocapas de nanocristales de MOFs de nanocapas de metal, iv) Separación de las superficies de los MOFs y obtención de las nanopartículas de Janus. La versatilidad de esta metodología nos ha permitido sintetizar diferentes compuestos de partículas Janus metal@MOFs, así como evaluar las propiedades magnéticas, fluorescentes, y catalíticas.
En el capítulo cuatro se describe otro de tipo de composites basados en MOFs y moléculas orgánicas funcionales. Este estudio consiste en introducir moléculas orgánicas funcionales creando defectos dentro de la estructura. En particular, se ha estudiado la capacidad de insertar la molécula xylenol orange; molécula con grupos coordinantes fuertes de tipo carboxílato con capacidad de capturar metales pesados. Se ha estudiado el mecanismo de incoprporación del XO dentro del MOF y su influencia en la formación del MOF, sus propiedades finales y la capacidad de eliminación de metales pesados del composite final fueron evaluados.The present Thesis has been dedicated to the study, development, and implementations of new methodologies synthesize Metal Organic Frameworks (MOFs) based multifunctional composites. Accordingly, two main lines of work can be distinguished through the lecture of this Thesis: i) the synthesis of Janus metal@MOFs particles and their partial functionalization for applications in removal of heavy metal ions, application in self-propelled and fluorescence; ii) the incorporation of active molecules into the MOFs through of creating controlled defects, and the use of the resulting composites in the removal of heavy metal ions. In the Chapter 1, we review the evolution of the field of the MOFs including a brief historical introduction and the presentation of the main synthetic routes, properties and applications. We pay special attention to the current methodologies to synthesis MOFs and their miniaturization and their improvements of their properties and their possible applications. We mention the importance of the possibilities as well to create MOF composites combining the intrinsic properties of MOFs and other functional materials (i.e. magnetic materials, fluorescence, catalytic). In Chapter 2, cites the general and specific objectives of this PhD Thesis. Chapter 3 describes the methodology used for the synthesis of Janus metallic@MOFs particles. This methodology is based on the selective evaporation of metallic components on the MOFs surfaces and is carried out in different steps: i) synthesis of MOFs and their control size; ii) fabrication of MOFs monolayers on surfaces through the controlled deposition based on solvent evaporation; iii) evaporation of metal components through the electron bean evaporation technique, iv) detachment of the MOFs from the surfaces obtaining the Janus metallic@MOFs nanoparticles. The versatility of this methodology has allowed us to synthesis different MOF based composites, and in addition, we present the magnetic, fluorescence and catalytic properties that were evaluated in different Janus metallic@MOFs nanoparticles. In chapter 4, we explored another kind of composites based on the combination of MOFs and organic functional molecules. We studied the incorporation of functional molecules into the MOFs creating defects into the network of the MOFs. In particular, we evaluated the incorporating of Xylenol Orange (XO) that has coordinative carboxylic groups and a strong capacity to chelate heavy metal ions. We studied the mechanism of the integration of XO into the MOF and their influence on the formation of the MOF, and in addition, we evaluated the final properties and specially the capacity to remove heavy metal ions.
16
鄭妙冰 and Christina Miu Bing Cheng. "Macau: a cultural janus in colonial vicissitudes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1996. http://hub.hku.hk/bib/B31234690.
Full text
17
Aleya, Tabka Hédi. "JANUS un thésaurus juridique sur micro-ordinateur /." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb37611179c.
Full text
18
Wotherspoon, Ross D. "Janus the multiple faces of engineering design /." Access electronically, 2001. http://ro.uow.edu.au/theses/1466.
Full text
19
Cheng, Miu-bing Christina. "Macau : a cultural janus in colonial vicissitudes /." Hong Kong : University of Hng Kong, 1996. http://sunzi.lib.hku.hk/hkuto/record.jsp?B17092437.
Full text
20
Liu, Wenbo. "Towards the synthesis of Janus-AT phosphoramidites." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44982.
Full textAbstract:
A Janus heterocycle is one kind of heterocycle that possesses hydrogen bonding donors or acceptors at both sides compared to regular nuclear bases. This provides an interesting synthetic target as well as a tool for testing an intriguing biological hypothesis related to DNA recognition, namely can both strands in the DNA duplex be recognized simultaneously by a single oligomeric strand of Janus heterocycles? In order to test this hypothesis, oligonucleotides containing at least one Janus heterocycle must be synthesized. One challenge involved in the synthesis of oligonucleotides with a Janus heterocycle is the extremely low solubility of Janus heterocycle phosphoramidites in organic solvents, namely MeCN. To solve the solubility issue, two sulfone-masked Janus-AT phosphoramidites were designed and constructed in this thesis. In addition to questions of solubility, the other obstacle related with Janus heterocycle oligonucleotide construction is the potential for deglycosylation, analogous to depurination, which might occur under the acidic conditions used during solid phase synthesis of oligonucleotides. The carbocyclic analog of deoxyribose, in lieu of 2-deoxyribose was employed to construct Janus heterocycle phosphoramidites in order to obviate the potential for depurination-like elimination of the nucleobase from the sugar.
21
Silva, Gilberto Lucio da. "Janus petrificado: autoridade, alteridade e estados normopáticos." Universidade Católica de Pernambuco, 2015. http://www.unicap.br/tede//tde_busca/arquivo.php?codArquivo=1038.
Full textAbstract:
A emergência em cada indivíduo de seu lugar enquanto sujeito exige a interação com um outro que também se reconheça na dualidade, na incompletude que permite estabelecer uma relação de alteridade. As formas de adoecimento psíquico caracterizadas como normopatia parecem se proteger do outro excessivamente intrusivo pelo cultivo da renegação da própria existência, vivendo o paradoxo de ser/produzir um semi-sujeito. Paralisados em eterna vigilância de seu espaço interno, esses sujeitos apresentam um grau diminuto de elaboração mental que se articula com um déficit da experiência subjetiva, de modo semelhante a outros distúrbios psíquicos frequentes na contemporaneidade: fuga da derivação para o somático, atuações perversas e pânico. Como objetivos desta pesquisa teórica procuramos descrever e problematizar o conceito de normopatia, suas aproximações e afastamentos de outras modalidades psicopatológicas, notadamente a neurose obsessiva e a perversão, bem como dos distúrbios do pânico e psicossomáticos. E, concomitantemente, caracterizar o manejo feito pelo analista/terapeuta no tratamento desses casos clínicos, com destaque para o aporte enriquecedor proporcionado pela psicanálise. Um objetivo secundário, mas essencial para a compreensão da importância que esse perfil psicopatológico assume na contemporaneidade, se expressa na busca de circunscrever o contexto social onde o sintoma normopático faz sentido, contexto que inclui o próprio fazer psicanalítico como produto e produtor de seu estatuto psicopatológico. Sobretudo, constata-se que este modo de relação (supressão da experiência subjetiva) revela um valor oculto, típico da modernidade, que preconiza a independência total do indivíduo diante do mundo social vivido. O trajeto metodológico incluiu a identificação e interpretação dos conceitos, a utilização de fragmentos clínicos para ilustrar aspectos do tema em estudo, a descrição da alteração nos processos civilizatórios e seu rebatimento nos grupamentos familiares, e a realização de comentário teórico a partir das contribuições e retomadas da obra freudiana nas diversas abordagens sobre o tema.
22
Aleya, Tabka Hédi. "Janus : un thésaurus juridique sur micro-ordinateur." Montpellier 2, 1988. http://www.theses.fr/1988MON20157.
Full textAbstract:
Ce thesaurus comporte deux niveaux: le premier niveau permet a l'utilisateur ignorant la terminologie des concepts contenus dans le thesaurus d'obtenir l'ensemble des concepts necessaires a une formulation adequate de sa question et un apercu global du domaine; le second niveau permet a l'utilisateur possedant une connaissance precise de la matiere d'exploiter la structuration de celle-ci au gre des relations suggerees
23
Semeraro, Enrico Federico. "Interactions effectives et dynamiques en systèmes actifs de colloïdes autopropulsés." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAV017/document.
Full textAbstract:
L’objectif de ce projet était l’étude systématique des interactions, de la microstructure et de la dynamique de suspensions de colloïdes qui imitent les mouvements de systèmes auto-propulsés (actifs), au moyen de techniques de diffusion : diffusion des rayons X aux (ultra) petits angles (USAXS/SAXS) et spectroscopie de corrélation de photons X (XPCS).À la différence des colloïdes passifs conventionnels (particules browniennes), les colloïdes actifs sont des systèmes hors équilibre faits d’objets auto-propulsés. Ces systèmes montrent une dynamique fascinante qui s’apparente aux mouvements de volée d'oiseaux, d’essaim d’insectes, etc.Les micro-organismes mobiles sont des exemples types de colloïdes actifs, notamment certaines variétés de bactéries, ou les colloïdes de type Janus caractérisé par une composition asymétrique de leur surface qui peux engendrer une propulsion, l’auto-diffusiophorèse. Les thèmes principaux de cette thèse sont les interactions inter-particule, les interactions particule-solvant et les dynamiques phorétiques des systèmes actifs.En premier lieu, la structure et la mobilité de la bactérie Escherichia coli ont été étudiées au moyen de SAXS/USAXS . Comme projet secondaire, l’obtention de données couvrant une très large gamme de vecteur de diffusion (q) a permis de dériver un modèle structural multi-échelle de la bactérie, en combinant les caractéristiques de colloïdes (corps cellulaire), de membranes (enveloppe cellulaire) et de polymères (flagelles). Ce modèle a été affiné au moyen de mesures complémentaires de diffusion de neutrons aux petits angles (SANS) sur des suspensions de la bactérie E. coli en variant le contraste externe (remplacement isotopique partielle du solvant) afin d’aboutir à une détermination quantitative de la densité électronique des membranes et des distances entre membranes.Ces bactéries ont ensuite été utilisées comme éléments actifs en mélange avec des colloïdes passifs de silice de taille sub-micrométrique, pour comprendre comment la présence de bactéries actives mobiles affecte les interactions effectives et la dynamique des colloïdes passifs. Des mesures USAXS et XPCS simultanées ont permis de déduire les propriétés statiques et hydrodynamiques de ces colloïdes passifs. Les données suggèrent que les bactéries actives se comportent comme un fluidifiant pour les colloïdes passifs, en réduisant leurs interactions attractives et en augmentant leur dynamique ; réciproquement, ces derniers sont affectés par la solution tampon et par la présence de bactéries augmente la viscosité environnante effective.Enfin, les mouvements phorétiques de colloïdes de silice et de type Janus (silice partiellement recouvert de nickel) suspendus dans un mélange de 3-methylpyridine (3MP) + eau/eau lourde pendant la séparation de phase liquide-liquide ont été investigués par USAXS et XPCS. Les mouvements des colloïdes sont fortement corrélés à la dynamique de la séparation de phase du fait de l’absorption préférentielle de 3MP à la surface de silice. Les colloïdes de silice montrent une dynamique advective avec une diffusion amélioré en direction des microdomaines riches en 3MP, évoquant la dynamique des systèmes auto-propulsés, jusqu’à l’aboutissement de la séparation de phase. Les suspensions de colloïdes de type Janus ont un comportement beaucoup plus complexe, la dynamique étant fortement corrélée aux interactions asymétriques avec le solvant. Cette dynamique est soit augmentée soit supprimée en fonction de la concentration en 3MP qui modifie aussi la micro-structure du système. Au lieu que les colloïdes de silice migrent vers la phase riche en 3MP, les colloïdes de type Janus agissent comme des tensioactifs en se plaçant à l’interface.Cette thèse démontre l’intérêt des techniques de diffusion pour explorer les propriétés des systèmes actifs et examiner leur comportement en thermodynamique hors équilibre afin de compléter les informations obtenues par observations microscopiqueThis project aimed to systematically investigate the interactions, microstructure and dynamics in suspensions of colloidal particles that mimic active motions, using (Ultra) Small- Angle X-ray Scattering (USAXS/SAXS) and X-ray Photon Correlation Spectroscopy (XPCS). As opposed to the conventional passive colloids (Brownian particles), active colloids are non-equilibrium systems consisting of self-propelled particles that display many fascinating dynamics, such as streaming, swarming, flocking, etc. in appropriate media. Practical examples of active systems are motile microorganisms, such as some species of bacteria, or synthetic Janus colloids – characterized by an asymmetric chemical composition of their surface – that can induce a propulsion mechanisms, like self-diffusiophoresis. The foci of this thesis are on interparticle interactions, particle-medium interactions and the phoretic dynamics in active systems.Firstly, the structure and motility of Escherichia coli bacteria were investigated by combined USAXS and SAXS methods. As an offshoot, the scattering data spanning a broad scattering vector (q)-range permitted the derivation of a multiscale structural model by combining colloidal (cell-body), membrane (cell-envelope) and polymer (flagella) features. This model was further refined by contrast-variation Small Angle Neutron Scattering (SANS) measurements on E. coli suspensions at three match points and the full contrast which allowed the determination of the membrane electron-density and the inter-membrane distances on a quantitative scale.These bacteria were then used as active component in a mixture with micron-sized passive silica colloids, with the aim of investigating how the effective interactions and dynamics of passive colloids are affected by the presence and the motility of active E. coli. Both static and hydrodynamic information were obtained via the simultaneous use of USAXS and XPCS techniques. Data suggested active bacteria act as a fluidizing agent in such systems, reducing attractive interactions and enhancing the dynamics of passive colloids, which, at the same time, are affected by the buffer and more viscous environment due to the bacterial presence.Finally, the phoretic motions of micron-sized silica colloids and half-coated silica/nickel Janus colloids suspended in a mixture of 3-methylpyridine (3MP) and water/heavy water undergoing liquid-liquid phase separation were investigated using USAXS and XPCS. Due to the preferential wetting of 3MP on the silica surface, the motion of the colloids is strongly correlated to the dynamics of phase separation.Silica colloids displayed advective motion with enhanced diffusion toward the 3MP-rich phase reminiscent of self-propelled motion until the phase separation is completed. Suspensions of Janus colloids showed a much richer scenario, where colloid dynamics are strongly influenced by the asymmetric interactions with the solvent. The dynamics of Janus colloids were either enhanced or suppressed depending on the 3MP concentration, which, concurrently, affected the microstructure of the system. As opposed to the partitioning in 3MP-rich phase in the case of silica colloids, Janus particles behave like surfactants at the interface.The thesis demonstrates the ability of studying active systems by means of scattering methods and probe their behaviour in the thermodynamic limit and complement the information derived from direct microscopy observations
24
Feil, Michael W. "A sensitivity analysis of the Janus(A) combat simulation that supports the use of Janus(A) in army training." Thesis, Monterey, California. Naval Postgraduate School, 1991. http://hdl.handle.net/10945/28524.
Full text
25
Wübbena, Jannes Bernhard [Verfasser]. "Controlling motion in quantum logic clocks / Jannes Bernhard Wübbena." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover (TIB), 2014. http://d-nb.info/1063005981/34.
Full text
26
Ziegler, Jannis [Verfasser]. "Prädiktoren der Letalität beim schweren akuten Lungenversagen / Jannis Ziegler." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/1194373151/34.
Full text
27
Andrae, Jannis [Verfasser]. "Rationalität, Demokratie und Reversibilität : Eine pragmatistische Perspektive / Jannis Andrae." Baden-Baden : Nomos Verlagsgesellschaft mbH & Co. KG, 2017. http://d-nb.info/1160478961/34.
Full text
28
Sammarchi, Andrea. "Il linguaggio Janus concorrente: definizione, compilazione e sperimentazione." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/19608/.
Full textAbstract:
In questo progetto vi è lo studio di Janus, un linguaggio di programmazione reversibile. Il progetto consiste nello sviluppo di un compilatore per Janus con un estensione che permetta una programmazione concorrente ed un servizio di message passing.
All'interno della tesi è presente un capitolo di background che presenta Janus e gli strumenti utilizzati. In seguito viene presentato il compilatore sviluppato e l'implementazione del meccanismo di concorrenza con il servizio di message passing. Infine viene mostrato come utilizzare il compilatore ed un ultimo capilo di sperimentazione. In quest'ultimo capitolo vengono mostrati alcuni esempi di programmi scritti in linguaggio Janus reversibile e concorrente.
29
Lovaszy, Steven Andrew. "Comparison of Bradley M2A2 and M2A3 using Janus." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1996. http://handle.dtic.mil/100.2/ADA321090.
Full textAbstract:
Thesis (M.S. in Operations Research and M.S. in Applied Mathematics) Naval Postgraduate School, September 1996.Thesis advisor(s): Bard K. Mansager, R.R. Read. "September 1996." Includes bibliographical references (p. 85). Also Available online.
30
Daniels, Charles L. "Comparison of fixed wing aircraft algorithms for JANUS." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1994. http://handle.dtic.mil/100.2/ADA288503.
Full text
31
Dykman, Dixon D. "A comparison study of JANUS and HLA Warrior." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2000. http://handle.dtic.mil/100.2/ADA380968.
Full text
32
Wang, Xiaolu. "Janus Colloids Surfing at the Surface of Water." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTS272/document.
Full textAbstract:
Considérant une particule isolée, la différence principale entre un colloïde actif et un colloïde passif réside dans le temps de persistance du régime balistique. La transition du régime balistique vers le régime diffusif est déterminée dans les deux cas par des coefficients de friction ou de manière équivalente par des coefficients de diffusion. Le mouvement d’une particule colloïdale passive micrométrique est diffusif lorsqu’il est observé sur des intervalles de temps d’au moins une microseconde, suffisamment longs pour que la direction de la quantité de mouvement soit rendue aléatoire par des collisions avec les molécules de solvant. A l’échelle macroscopique ces collisions se traduisent par un coefficient de friction de translation. Pour une particule colloïdale active, un mouvement diffusif est observé pour des intervalles de temps de plusieurs secondes, suffisamment longs pour que la direction d’auto-propulsion soit rendue aléatoire par la diffusion rotationnelle de la particule.Dans cette thèse, nous étudions le mouvement d’une particule colloïdale active déposée à la surface de l’eau. Des particules Janus aux propriétés catalytiques ont été préparées par dépôt de platine métal à la surface de particules de silice. La profondeur d’immersion des particules ainsi que leur orientation par rapport à la surface de l’eau ont été caractérisées et discutées en tenant compte des propriétés de mouillage non-uniformes de la surface des particules Janus. Le mouvement de particules isolées en présence de quantités variables d’eau oxygénée utilisée comme source d’énergie, a été enregistré par vidéo-microscopie optique et les trajectoires analysées en termes de déplacement carré moyen et de fonction d’auto-corrélation des vitesses. L’observation de deux types de trajectoires, rectilignes et circulaires, révèle la force effective ainsi que le couple induit par la décomposition catalytique de l’eau oxygénée à la surface de la particule Janus. Le résultat principal de ce travail est que le mouvement des particules actives confinées à l’interface persiste plus longtemps dans le régime balistique que celui de particules actives totalement immergées en solution. Ceci est dû au confinement qui réduit le nombre de degrés de liberté de rotation mais aussi aux conditions de mouillage partiel qui font apparaître des contributions supplémentaires à la friction de rotationAt the single-particle level, the main difference between active colloids and passive ones is the time scale over which the motion crosses over from ballistic to diffusive regime. In both cases, friction coefficients or equivalently diffusion coefficients determine this time scale. For instance, the motion of a passive colloid of 1m radius is diffusive when observed over lag times longer than a microsecond, once the direction of its momentum has been randomized by collisions with solvent molecules. At the macroscopic scale these collisions are accounted for by the translational friction coefficient. For an active colloid the effective diffusive behavior observed over lag times larger than few seconds results from the randomization of the direction of self-propulsion by rotational diffusion. In this thesis we investigated the motion of an active Janus colloid trapped at air-water interface. Spherical catalytic Janus colloids have been prepared through the deposition of platinum metal at the surface of silica particles. Immersion depth of the Janus colloid as well as their orientation with respect to the water surface, has been characterized and interpreted in terms of the non-uniform wetting properties of the Janus particles. The motion of the active Janus colloids in the presence of various concentration of hydrogen peroxide H2O2 as fuel was characterized by video microscopy and the trajectories analyzed through the mean square displacement and the velocity autocorrelation function. The types of trajectories, directional and circular ones that we observed in our experiments, revealed the effective force and torque induced by the catalytic decomposition of H2O2. At the water surface, active colloids perform more persistent directional motions as compared to the motions performed in the bulk. This has been interpreted as due to the loss of degrees of freedom resulting from the confinement at interface and also to the partial wetting conditions that possibly bring new contributions to the rotational friction at interface
33
Lu, Xiaoxu. "A FACILE METHOD TO FABRICATE VERSATILE JANUS NANOPARTICLES." University of Akron / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1468852508.
Full text
34
Athie, Morales Veronica. "Interleukin 12 signalling pathways in human T lymphocytes." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249566.
Full text
35
McFadden, Willie J. "Comparison of Janus(A) simulated terrain vegetation codes to modified Janus(A) terrain vegetation codes for the Javelin antitank operational test." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1993. http://handle.dtic.mil/100.2/ADA273159.
Full textAbstract:
Thesis (M.S. in Operations Research) Naval Postgraduate School, September 1993.Thesis advisor(s): Mansager, Bard K. ; Kemple, William G. "September 1993." Cover title: Comparison ... modified terrain ... Bibliography: p. 43. Also available online.
36
Deng, Luqin. "Determinants of growth hormone receptor downregulation." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2009p/deng.pdf.
Full text
37
Vieira, Andre Schwambach 1982. "Papel da Janus Quinase 2 expressa em tecido nervoso na hiperalgesia inflamatória." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313997.
Full textAbstract:
Orientador: Carlos Amilcar ParadaTese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
Made available in DSpace on 2018-08-20T09:59:35Z (GMT). No. of bitstreams: 1 Vieira_AndreSchwambach_D.pdf: 871138 bytes, checksum: fc1ecaa5a27015a5ae9ed72d9687b540 (MD5) Previous issue date: 2012
Resumo: A hiperalgesia inflamatória resulta da sensibilização de nociceptores aferentes periféricos induzida por mediadores inflamatórios. A prostaglandina E2 (PGE2) é uma das principais moléculas sinalizadoras envolvidas na hiperalgesia, sendo capaz de agir diretamente em nociceptores, induzindo mudanças nas propriedades de transdução sensorial destas células. A Janus Quinase 2 (JAK2) é uma molécula sinalizadora intracelular geralmente associada ao mecanismo de ação de citocinas, sendo que sua atividade pode ser induzida em nociceptores após uma inflamação periférica. Entretanto, não existem evidencias do envolvimento direto da JAK2 na sensibilização de nociceptores mediada pela PGE2. Assim o objetivo deste trabalho foi de explorar o possível papel da JAK2 na sensibilização mediada pela PGE2. Em neurônios do gânglio da raiz dorsal (DRG) em cultura foi observado que a PGE2 altera o influxo de cálcio induzido pela capsaicina, e a pré-incubação das células com o inibidor seletivo da JAK2, AG490, foi capaz de bloquear este efeito. Adicionalmente, a administração intratecal de AG490 em ratos reduziu a hiperalgesia induzida pela administração subcutânea e local de PGE2 ou carragenina. A administração intratecal de AG490 também bloqueou a ativação da PKCepsilon induzida no DRG L5 ispsilateral após inflamação na pata. Em conclusão o presente trabalho demonstra que a JAK2 expressa no DRG pode possuir um papel na sensibilização de nociceptores induzida por um evento inflamatório periférico. Desta forma a inibição da JAK2 pode ser um novo alvo farmacológico para o controle da hiperalgesia inflamatória
Abstract: Inflammatory hyperalgesia results from the sensitization of peripheral afferent nociceptors by inflammatory mediators. Prostaglandin E2 (PGE2) is one of the major signaling molecules involved in hyperalgesia, being able to act directly on nociceptors, inducing sensitization. The Janus Kinase 2 (JAK2) is an intracellular signaling molecule generally associated with cytokines signaling pathway, and its activity can be increased in nociceptors after peripheral inflammation. However, there are no evidences about the role JAK2 directly plays in PGE2-induced sensitization of nociceptors. Therefore, the aim of the present study was to explore a possible role for JAK2 in PGE2 mediated sensitization. The data of this study showed in cultured dorsal root ganglion (DRG) neurons, that the administration of PGE2 alters capsaicin-induced calcium transients, and the pre-incubation of the cells with the JAK2 selective inhibitor AG490 blocks this effect. In addition, the intrathecal administration of AG490 in rats reduces the hyperalgesia induced by local administration of PGE2 or carrageenan in the hindpaw. AG490 intrathecal administration also blocks PKCepsilon activation in the ipsilateral L5 DRG induced by inflammation of peripheral tissue. In conclusion, the present study indicates that the JAK2 expressed in the DRG may have a role in the sensitization of nociceptors by a peripheral inflammatory event. Moreover, the inhibition of JAK2 may be a possible novel pharmacological target for the control of the inflammatory hyperalgesia
Doutorado
Fisiologia
Doutor em Biologia Funcional e Molecular
38
Ly, Aboubakry. "Effet Seebeck à l’échelle nanométrique de nanostructures chaudes." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0010/document.
Full textAbstract:
L'objectif de ce travail est d'étudier l'effet thermoélectrique à l'échelle nanométrique des nanostructures chauffées. Dans un premier temps, nous étudions les mécanismes d'autopropulsion thermo-électrophorétique de particules Janus chauffées par laser. Ce mécanisme d'autopropulsion est principalement induit par l'effet Seebeck ou l'effet thermoélectrique. Cet effet provient de la séparation des charges survenues lorsqu'un gradient de température est présent dans la solution d'électrolyte: Une forte absorption du laser par la partie métallisée de la particule génère un gradient de température qui en retour agit sur les espèces ioniques (positive et négative) et les conduits vers les zones chaudes ou les zones froides. Ce mouvement d'ions entraine la création d'un champ électrique dipolaire qui, à proximité de la particule, dépend fortement des propriétés de surface. Ce changement de comportement de ce champ électrique sur une surface isolant ou conductrice n'affecte pas la vitesse de la particule. Dans un second temps, nous étudions les effets d'interactions hydrodynamiques et de la condensation des contre-ions sur la thermophorèse des polymères d'ADN. Comme résultat principal, la mobilité thermophorétique montre, en fonction de la longueur de la chaîne, un comportement non-monotone et se compose de deux contributions induites par les forces conductrices dominantes que sont l'effet Seebeck et le gradient de permittivité. À la fin, nous comparons notre résultat théorique avec une récente expérience sur l'ADNThe aim of this work is to study the nanoscale Seebeck effect at hot nanostructures. At first, we study the thermo-electrophoresis self-propulsion mechanism for a heated metal capped Janus colloid. The self-propulsion mechanism is mainly induced by the electrolyte Seebeck effect or thermoelectric effect. This effect takes its origin from the separation of charges occurring while a temperature gradient is present in a electrolyte solution: A strong absorption of laser light by the metal side of the particle creates a temperature gradient which in turn acts on ion-species (positive and negative) and drives them to the hot or the cold region. This motion of ion results in a dipolar electric field which, close to the particle, depends strongly on the surface properties. The change of behavior of the electric field at the insulating or conducting surface does not affect the velocity of the particle. At second, we study the effect of hydrodynamic interactions and counterion condensation in thermophoresis for DNA polymer. As the main result, the thermophoretic mobility shows, in function of the chain length, a non-monotonuous behavior and consists of two contributions induced by the dominant driving forces which are the thermally induced permittivity-gradient and the electrolyte Seebeck effect. At the end, we compare our theoretical result with recent experiment on single-stranded DNA
39
Ruhland, Thomas [Verfasser], and Axel [Akademischer Betreuer] Müller. "Janus Particles at Interfaces / Thomas Ruhland. Betreuer: Axel Müller." Bayreuth : Universität Bayreuth, 2013. http://d-nb.info/1059352737/34.
Full text
40
Ersson, Elin. "Janus ala Cuba : Filmiska gestaltningar av den kubanska revolutionen." Thesis, Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-21119.
Full textAbstract:
Denna uppsats undersöker hur samma historiska händelse kan ha olika betydelser i film. Idag är människor mer benägna att se en film om en historisk händelse än att läsa en historiebok, och detta innebär att vi måste lära oss att förstå de konventioner som används för att placera historia på film. Historiefilmen kan sägas besitta en palimpsestisk historiskt medvetenhet där lager av fakta och myt smälter samman, hellre än att skiljas åt. Men för att en historisk händelse ska passa in i filmens tidsram måste den bearbetas och detta resulterar i att vissa människor, händelser och rörelser prioriteras, medan andra utesluts. Därför undersöker denna uppsats vad som lagts till / uteslutits och effekterna på sammanhanget och trovärdighet, hur filmen hävdar sin autenticitet, och hur upphovsmannen påverkar trovärdigheten. Analysresultaten av två filmer om den kubanska revolutionen, visar att beroende på vilken del av den historisk händelsen som skildras, skapar filmerna helt olika berättelser med olika budskap. Medan filmen Che-Argentinaren (2008) fungerar som en hyllning av gerillanledaren Che Guevara som Kubas frälsare, visar en vänsterideologi och uttrycker USA förakt, skildrar däremot den andra filmen The Lost City (2005) revolutionens baksida. Den visar en högerideologi, familjevärderingar och USA som frihetens och drömmarnas land. Båda filmerna använder sig av liknande stilistiska strategier för att uppnå illusionen av autenticitet, och filmernas upphovsmän påverkar filmernas trovärdighet i olika grad. Vad jag i uppsatsen till sist menar är att historiefilmen inte bör tas som sanning, utan har en viktig roll som intresseväckare, som förhoppningsvis leder till att åskådaren blir intresserad av att söka sig mer kunskap.This paper examines how the same historical event can have different meanings in films. Today people are more likely to watch a film about a historical event than to read a history book, and this means that we must learn and understand the conventions used to place history on film. The history film can be said to possess a palimpsetic historical consciousness in which layers of fact and myth come together rather than be separated. But for a historical event to fit within the film's time frame, it must be processed and this results in that certain people, events and movements are given priority, while others are excluded. Therefore, this paper studies what has been added/excluded and the effects on the context and credibility,how the film claims its authenticity, and how the author/filmmakers affects the credibility. The results of the analysis of two films about the Cuban revolution, shows that depending on which part of the historical event depicted, the films create entirely different stories with very different message. While the film Che-Part One (2008) serves as a celebration of the guerrilla fighter Che Guevara as Cuba's savior, according to a leftist ideology and the film is expressing U.S. disdain, the other film The Lost City (2005) however, portrays the revolutions backside, it shows a right-wing ideology, family values and the U.S. as the land of freedom and dreams. Both films use similar stylistic strategies to achieve illusion of authenticity, and the films' creators affect the films credibility in different amounts. What I finally conclude, is that the history film should not be considered as truth, but serve to arouse interest, which will hopefully lead the spectator to seek more knowledge about the historical event.
41
Bodén, Stefan. "Janus två ansikten : En studie om kökslärarens dubbla roller." Thesis, Stockholms universitet, Institutionen för utbildningsvetenskap med inriktning mot tekniska, estetiska och praktiska kunskapstraditioner, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-59801.
Full textAbstract:
This is a field study based on participant observations and interviews, describing the cooking teacher's complex everyday life. The school's restaurant is a unique arena, freely hovering between two worlds: The school world and the restaurant reality. Here, the students are confronted with real situations and problems, similar to the ones occurring in a restaurant, still having the school's safety net beneath them. It is for real, but still not, a bit like a flight simulator. It is on that arena the cooking teacher works, combining the two roles of the teacher and the chef. Two roles built on their own traditions and values. This study illustrates the fluctuations and conflicts that arise between these role changes. With two different practices, those of the school and of the restaurant, an issue is raised by the end of the study; can you discuss in terms of different didactics? In addition to subject matter didactics and professional didactics that are recognized concepts, can we also speak in terms of vocational education didactics?
42
Whitney, Mark R. "Visualization of improved target acquisition algorithm for Janus (A)." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1994. http://handle.dtic.mil/100.2/ADA290191.
Full text
43
Leis, Paiva Felipe. "Interfacial behavior of Janus rods-stabilized immiscible polymer blends." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1593868264853478.
Full text
44
Rohde, Jannis [Verfasser]. "Modellerweiterungen des Cell Transmission Model (CTM) für städtische Hauptstraßennetze / Jannis Rohde." Aachen : Shaker, 2017. http://d-nb.info/1138177830/34.
Full text
45
Ochsmann, Jannis Walther [Verfasser]. "Stress & structure of thin polymer brush films / Jannis Walther Ochsmann." Mainz : Universitätsbibliothek Mainz, 2012. http://d-nb.info/1024517063/34.
Full text
46
Quer, Jannes [Verfasser]. "Importance sampling for metastable dynamical systems in molecular dynamics / Jannes Quer." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/1176632485/34.
Full text
47
Kröger, Kai Jannes [Verfasser]. "Osteonekrose des Mondbeins bei Patienten mit systemischer Sklerose / Kai Jannes Kröger." Gießen : Universitätsbibliothek, 2018. http://d-nb.info/1171131356/34.
Full text
48
Randoll, Sven-Jannis [Verfasser]. "Die Casein-Kinase-1delta (CK1delta): Identifizierung von Regulationsmechanismen / Sven-Jannis Randoll." Ulm : Universität Ulm. Medizinische Fakultät, 2014. http://d-nb.info/1046889974/34.
Full text
49
Sarue, Sarita Mucinic. "Janusz Korczak diante do sionismo." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/8/8152/tde-31012013-131216/.
Full textAbstract:
Este trabalho se propõe a estudar Janusz Korczak e sua relação com o judaísmo e o sionismo. Korczak foi um judeu-polonês, nascido em Varsóvia em 1878, e pertencia a uma família de eruditos bastante assimilada, sentindo-se um verdadeiro polonês. Foi médico, educador, jornalista, escritor e criador de dois orfanatos baseados nos princípios democráticos de educação: um judaico, Don Sierot (1912-1942); e outro cristão, Nasz Dom (1919-1936). A análise de correspondências, relatos de viagem, entrevistas, entre outros documentos associados à relação de Korczak com o judaísmo, o sionismo e a Terra de Israel, permitiu conhecer a visão de Korczak sobre a questão judaica em uma Polônia antissemita dos séculos XIX e XX. No tocante aos relatos de viagem, foram analisados documentos referentes às duas viagens do autor à Terra de Israel, incluindo impressões pessoais referentes tanto aos benefícios dessa Terra, como às dificuldades de adaptação à terra dos ancestrais e o abandono da terra natal. Korczak pretendia emigrar para a Palestina, porém foi vítima da Shoá e juntamente com as duzentas crianças judias e os educadores do orfanato, foi levado do Gueto de Varsóvia para o trem que os levaria a Treblinka.The present work intends to study Janus Korczak and his relation with judaism and sionism. Korczak was a polish jew, borned in Warsaw, in 1878, who belonged to a family of assimilated scholars and felt trully polish. He was a phisician, an educator, a journalist, a writer and founder of two orphanages, that followed the democratic principles of education: one of them jewish, Don Sierot (1912-1942) ) and the other one christian, Nasz Dom (1919-1936). The analysis of correspondences, interviews, and other documents related to judaism, sionism and the land of Israel, allowed us to aknowledge Korczaks vision of the jewish question in an antisemitic Poland of the 19th and 20th centuries. The documents analised referred mainly to the two trips that Korczak made to the land of Israel, and included his personal impressions of the benefits of the Land, as well as the difficulties of adaptation to this ancestral ground, and of leaving the homeland for good. Altough Korczak intended to emigrate to Palestine, he was not able to do it, because as a victim of the Shoah, he was sent, with the 200 jewish children and the teachers of his orphanage, from the Guetto of Warsaw to the train hat would lead them to Treblinka.
50
Weil, Janus [Verfasser]. "Vector mesons in medium in a transport approach / Janus Weil." Gießen : Universitätsbibliothek, 2013. http://d-nb.info/1065463103/34.
Full text