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1
Cheung, Tak-sum Thomas. "Comparison of spiral tomography (Scanora) with ridge mapping and plain film radiography for dental implant planning in partially dentate jaws." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25068581.
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Bin, Syed Omar Syed Nabil. "Osteoradionecrosis of the jaws: analysis of the evidence." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44661265.
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Wannfors, Karin. "Chronic osteomyelitis of the jaws." Stockholm : Kongl. Carolinska Medico Chirurgiska Institutet, 1990. http://catalog.hathitrust.org/api/volumes/oclc/24827817.html.
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Yang, Jun. "Reflex control of human jaw muscles by periodontal mechanoreceptors." Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phy219.pdf.
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Copies of author's previously published articles inserted. Bibliography: leaves 169-219. Describes experiments to determine what factors affect the outcome of the reflex response of the jaw closing muscles to peridontal mechanoreceptive stimulus. The reflex responses of the human masseter were investigated by applying force using different stimulus profiles. It was shown that when the force profile had little or no fast component, the likelehood of eliciting an exitatory peridontal masseteric reflex increased. It is concluded that the shape of the stimulus profile, the location of the stimulating probe and the presence of preload are the main factors that determine the exitatory reflex response of the jaw closing muscles.
5
Lueveswanij, Somyot. "A clinical study of 626 jaw cysts in southern Chinese patients." Thesis, Click to view the E-thesis via HKUTO, 1994. http://sunzi.lib.hku.hk/HKUTO/record/B38628478.
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MacDonald, David Stanislaw. "Fibro-osseous lesions affecting the jaws." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/24865.
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Fibro-osseous lesions (FOLs) affecting the jaws represent an important category both diagnostically and therapeutically. The overwhelming majority of cases of cemento-osseus dysplasia (COD) require no treatment, whereas its florid (affects more than one sextants of the jaw) form, in particular, raises significant risk of prosthodontic failure in the elder patient. The cemento-ossifying fibroma (COF) is a benign, occasionally aggressive, neoplasm requiring complete enucleation to obviate recurrence. Fibrous dysplasia (FD) is a harmatoma in most cases, but on occasion displays neoplastic behaviour. Diagnosis is normally achieved upon both clinical and radiological evaluation. Aims: Review the consecutive case of these lesions affecting a Hong Kong population, almost exclusively Chinese, whose oral lesions until only recently have not featured prominently in the international literature. Conduct a systematic review (SR) on the world literature pertaining to FOLs. Materials and Methods: all consecutive cases on CODs, COFs and FDs managed at the Dental School of the University of Hong Kong (HKU) from 1982 to 1992 for CODs and onwards to 2004 for COFs and FDs were identified. Results: Twenty-three Florid CODs, 6 Focal CODs, 24 COFs and 21 FDs (1 bimaxillary) were identified and their clinical and radiological features analysed and inserted into the SRs. All Florid CODs and COFs were female. Florid CODs identified as incidental findings and retained in radiology files were significantly younger than those derived from pathology files. COFs in the SR had significant predilections for females and the mandible and to be detected as radiolucencies, whereas the FD more significantly displayed radiologically, expansion of the buccolingual cortices, and of the lower border of the mandible. Clinically, the Florid CODs were significantly associated with pain, FDs were more significantly associated with swelling, FocCODs were also more significantly found incidentally.
7
Cheung, Tak-sum Thomas, and 張德森. "Comparison of spiral tomography (Scanora) with ridge mapping and plainfilm radiography for dental implant planning in partially dentatejaws." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31954212.
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Brinkworth, Russell Stewart Anglesey. "Response of the human jaw to mechanical stimulation of teeth." Access PDF text via HTML index, 2004. http://hdl.handle.net/2440/37934.
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Animal experiments indicate that the main form of feedback for jaw-closing muscles is from periodontal mechanoreceptors (PMRs). However, due primarily to limitations on methods, this is yet to be confirmed in humans. The main aim of this thesis was to investigate the reflex contribution of PMRs to the human jaws using vertical (axial) stimulation. To this end the electromyographic and bite force responses of the jaw to a number of different mechanical stimulus conditions, delivered to both the upper central incisors and the upper right first molars, were investigated. The principal hypothesis was that PMRs are responsible for the majority of the reflex responses seen in the human jaw muscles. Furthermore this reflex response is modulated by different characteristics of the stimulus such as: rate of rise, maximum force applied, the amount of constant offset force (preload), the level of muscle contraction and also the physical characteristics of the subject's jaw including: dental health and tooth spacing. These studies have contributed towards the understanding of the neuronal wiring and the receptor systems contained in the jaw. The results indicate that PMRs around the incisors are of fundamental importance for the development of reflex patterns but little if any PMR related reflexes exist around the molar teeth. The reflexes originating from the PMRs around the incisors are modulated by different mechanical characteristics of the stimulus, thus helping to explain how the jaw muscles perform numerous and complex patterns of activation which move the jaw in many different ways and develop forces that are optimum for the task at hand.Thesis (Ph.D.)--School of Molecular & Biomedical Science, 2004.
9
Hulsey, Christopher Darrin. "Functional micro and macroevolution in fish jaws /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2004. http://uclibs.org/PID/11984.
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Pearce, Sophie. "Motor cortical control of human jaw muscles : a thesis submitted for the degree of Doctor of Philosophy in the Department of Physiology, the University of Adelaide, Adelaide, South Australia /." Title page, table of contents and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09php3595.pdf.
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Hoshyar, Ramesh Mohammad Alizadeh. "Immunocharacterisation of giant cell lesions of the jaws /." Title page, table of contents and summary only, 1997. http://web4.library.adelaide.edu.au/theses/09DM/09dmh825.pdf.
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Thesis (M.D.S.)--University of Adelaide, Dept. of Dentistry, 1998?Addendum of text pasted on verso of Table of Contents. Addendum of references pasted on back fly-leaf. Includes bibliographical references (leaves 67-78).
12
Chong, Mei-man, and 臧薇敏. "Three-dimensional comparison of the upper airway in various types of dentofacial deformities." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48542027.
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Objectives
1. To define the normative airway of Chinese population using three-dimensional imaging and computer analysis
2. To evaluate the upper airway differences in patients with normal facial profile and those with skeletal class III deformity
3. To evaluate the differences in upper airway models among patients with different dentofacial deformities and describe the role of computational fluid dynamics (CFD) in the human upper airway
Materials and Methods
Part I : Three-Dimensional Analysis of the Normative Upper Airway in Chinese
This was a cross-sectional observational study. Cone beam computerized tomography (CBCT) scans of one hundred patients were analyzed. Computer analysis of the different upper airway parameters were studied including airway length and volume, as well as airway dimensions at the axial level of the soft palate, hard palate, base of tongue, and epiglottis. The most constricted airway location was identified and correlation analysis with variables of interest was done.
Part II: A Cone Beam Computerized Tomography Study of Airway in Skeletal Class I and Class III
Cone-beam computed tomography (CBCT) records of 200 patients were used to evaluate the upper airway dimensions. This sample consisted of patients with normal facial profile (Class I) and those demonstrating skeletal class III deformities. Computer analysis of the upper airway parameters such as airway length, airway volume, airway anterior-posterior and cross-sectional area dimensions at the hard palate, soft palate, base of tongue and epiglottis were performed. The most constricted airway sites were identified.
Part III: Computational fluid dynamics study of upper airway in different dentofacial deformities
Cone-beam computed tomography records of 12 patients were used to evaluate the upper airway. This sample consisted of facial skeletal Class I, II and III subjects. The upper airway models were constructed to allow CFD simulations in the airway from the epiglottis to the hard palate. Cross-sectional area, pressure, velocity and resistance were measured based on the reconstructed meshed models.
Results
Part I : Three-Dimensional Analysis of the Normative Upper Airway in Chinese
In 100 subjects (40 males, 60 females) aged 16-40 years with normal facial profile, we found that the most constricted site occurs at the level of the soft palate. This surface area of this site was found to be linearly correlated to the airway volume, suggesting a significant relationship between the most constricted area and the total airway volume. Gender differences were found in airway length, volume, and in the dimensions at the base of tongue and epiglottis region. The mean airway length was 54.12 mm + 6.19 for males and 49.25 mm + 4.86 for females; airway volume of 15.09 cm3 + 4.92 for males and 13.12 cm3 + 4.72 for females.
Part II: A Cone Beam Computerized Tomography Study of Airway in Skeletal Class I and Class III
The sample consisted of 100 Class I (41 males, 59 females) with a mean age of 25.4 years and 100 Class III (38 males, 62 females) with a mean age of 23.5 years. Gender differences were noted in the airway length, airway volume and dimensions at the base of tongue and epiglottis for both groups. Males showed longer airway length, larger airway volume, larger airway dimensions at the base of tongue and epiglottis compared to females. Significant differences in all the airway parameters between the two groups were found except for airway length. The soft palate was found to be the most constricted airway site observed in the Class I subjects while Class III subjects showed restriction in both the soft palate and epiglottis region.
Part III: Computational fluid dynamics study of upper airway in different dentofacial deformities
The airflow was variable among airway in different skeletal deformities. The pressure changes along airway of Class II were the largest, followed by Class I. The pressure drop in the airway of Class III subjects were the smallest. The larger pressure differences would cause greater resistance in the airway. The highest resistance was observed in the airway of Class II subjects.
Conclusion
Part I : Three-Dimensional Analysis of the Normative Upper Airway in Chinese
This airway data provide a normative reference that can be used in various dentofacial analysis as well as for diagnosis and treatment planning for related dentofacial deformities and in understanding the pathophysiology for sleep-related breathing disorders.
Part II: A Cone Beam Computerized Tomography Study of Airway in Skeletal Class I and Class III
The upper airway is larger in patients with Class III deformity than those with a normal facial profile. The site of restriction is commonly observed at the soft palate in the Class I group whereas patients with Class III deformity, the airway restriction sites are at both the soft palate and epiglottis. Understanding of the upper airway differences in between class I and class III facial deformities can have implications on treatment planning for orthognathic surgery.
Part III: Computational fluid dynamics study of upper airway in different dentofacial deformities
The results in this study suggest that skeletal pattern showed a significant correlation with pressure and resistance along the upper airway.published_or_final_version
Dental Surgery
Master
Master of Dental Surgery
13
Hariri, Firdaus. "Alveolar distraction osteogenesis for dental implant rehabilitation inreconstructed jaws." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44661514.
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Marks, Lori J. "Software Applications for the Blind: JAWS and Virtual Pencil." Digital Commons @ East Tennessee State University, 2006. https://dc.etsu.edu/etsu-works/3674.
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Castaldo, Lundén Elizabeth. "Jaws: Creating the Myth of the Man-Eating Machine." Thesis, Stockholms universitet, Filmvetenskapliga institutionen, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-89349.
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Jaws(Universal Studios, 1975) set a new standard for Hollywood film production byintroducing the concept of “summer blockbuster,” for a film that changed the way inwhich people thought about sharks. 37 years after the release of the movie, the idea of sharks as ferocious man-hunters still looms large in public opinion. Thisconceptualization of sharks as ruthless killers is mythical rather than factual, and thisresearch tracks the mechanisms that propelled the idea deep into popular culture.The dissertation addresses the problematics of media constructions through a casestudy of the movie Jawsdeparting from its production process, and by applyingBarbara Klinger’s interpretation of “epiphenomena.” The thesis studies how cinematravels into popular culture, by following the traces of the movie into other media, andits dialogue with the surrounding texts generated by PR, marketing andmerchandising; simultaneously, the thesis seek to demonstrate the connection between the movie as mythmaker and the stigmatized portrayal of sharks.
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Holliday, Casey M. "Evolution and function of the jaw musculature and adductor chamber of archosaurs (crocodilians, dinosaurs, and birds)." Connect to this title online, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1147280827.
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Lee, Kin-man, and 李健民. "The management of unicystic ameloblastoma: effect of Carnoy's solution on recurrence rate." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B38628041.
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Li, Chunlei, and 李春蕾. "Role of periodontal diseases in bisphosphonate-related osteonecrosis of the jaws." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208556.
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Becconsall, Karyn, and n/a. "Analysis of radiolucent jaw lesions in a New Zealand population over a twenty-year period." University of Otago. School of Dentistry, 2008. http://adt.otago.ac.nz./public/adt-NZDU20081202.144835.
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The maxilla and mandible may be affected by a wide variety of lesions of developmental, neoplastic or inflammatory origin. These lesions have a vast array of clinical and radiographic presentations from which a dentist forms a clinical provisional diagnosis and treats the lesions accordingly. The aim of this study was to determine the range, demographic and clinical features of all histologically diagnosed radiolucent jaw lesions in a New Zealand population over a twenty-year period. Additionally, the provisional diagnosis was compared to the histopathological diagnosis in an effort to gain an insight into the difficulties practitioners face in clinically diagnosing radiolucent jaw lesions.
Material and Methods: From the histopathology diagnostic service at the University of Otago School of Dentistry all specimens with a diagnosis of a radiolucent jaw lesion between 1986 and 2006 were retrieved and classified into six diagnostic categories. For each lesion the age, gender, site, clinical presentation, clinicians provisional diagnosis and the final histological diagnosis was gathered and analysed.
Results: During the study period 4983 specimens were identified as radiolucent jaw lesions. The diagnostic category with the largest number of specimens was inflammatory lesions (72.8%), followed by developmental odontogenic cysts (21.8%). Malignant tumours accounted for less than 1% of all specimens. Concordance of provisional and histopathological diagnoses ranged from 81.0% for nasopalatine duct cyst to 0% for the majority of intra-osseous malignant tumours.
Conclusions: The range and demographic features of radiolucent jaw lesions in this study are comparable to that of other populations with a European majority. No radiolucent jaw lesion can be reliably accurately diagnosed from clinical presentation and radiographic appearance alone.
20
Singh, Baldev. "Prevalence of postoperative infection after orthognathic surgery." Thesis, Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23234635.
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Grykuliak, Glenna M. "Electroymyographic data and post-exercise pain in female muscle pain and control subjects after experimental chewing." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0002/MQ34370.pdf.
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Chan, Siew-luen, and 陳兆麟. "A cephalometric study of dentoalveolar hyperplasia in dentofacial deformities." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1994. http://hub.hku.hk/bib/B31953979.
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Pelster-Wiebe, Richard. "In the jaws of death: Leon Caverly’s camera-history of World War I." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6663.
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This dissertation argues that a critical anti-war cinema emerged with the birth of the so-called war documentary during World War I. Focusing on Leon Caverly, the first official war cinematographer of the United States military, I that argue America’s first war propaganda films gave birth to America’s first anti-war cinema. Military-produced images of World War I are available in various archives such as the Library of Congress, the National Archives, and the Marine Corps History Center. In addition to unedited reels of war related footage, the archives hold propaganda films such as Pershing’s Crusaders (1918), America’s Answer (1918) and Under Four Flags (1918). These feature films were shot by cameramen in the Marines or the Signal Corps and then edited into works of propaganda by the United States Government’s Committee on Public Information. Caverly was the first cameraman to join the effort of filming at the front. While he was a Marine and an instrumental player in America’s propaganda program, he also completed a cinematic history of the Great War through his creative nonfiction camerawork that was more subtle and critical than conventional war documentaries would suggest.
Previous studies of World War I propaganda provide context for America’s cinematic efforts or profiles of individual cameramen. But little or no attention has been paid to formal analysis of the films themselves. Furthermore, scholars have not yet regarded these films as anything other than examples of early documentary or government propaganda. The same holds true concerning Leon Caverly. Not only was Caverly the first United States war cinematographer, but the most significant work of propaganda made during the war was composed of footage shot entirely by him. Released in 1918, America’s Answer captivated audiences in America and Europe, providing inspiration for the home front to support the war. However, a striking discrepancy exists between the content of Caverly’s shots and the rhetorical editing structure of the film. In contrast to the pro-war sentiment articulated by the editing and its intertitles, America’s Answer’s individual shots reveal a practice of camera-writing that represents an aesthetics of anti-war cinema at odds with pro-war propaganda.
Caverly’s work does not show the horrors of war with documentary realism. Nor does his work openly critique America’s war effort. Rather, Caverly aspires to be a camera-historian whose moving images and photographic work demonstrate a preoccupation with writing history steeped in the temporal aesthetics of the camera arts. This dissertation considers still and moving image practices that “write with time” such as double-exposures, shots that emphasize duration, moving camera shots that evoke temporal relationships, and framing that gives metaphorical expression to time. The fact that these practices appear in Caverly’s wartime work indicates that World War I footage has a greater significance for film history than simply exemplifying documentary realism or propaganda. This dissertation shows that, while the most harrowing aspects of World War I combat remain unseen in Caverly’s work, his creative camera-writing approaches war and the fragility of life in unconventional ways.
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Sebrén, Åsa, and Helena Nelson. "Medical treatment of chronic non-infectious osteomyelitis in the jaws. A systematic review." Thesis, Malmö universitet, Odontologiska fakulteten (OD), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19626.
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Syfte: Att systematiskt sammanfatta litteraturen inom området för medicinska behandlingsalternativ för icke-infektiös, kronisk osteomyelit i käkarna, utvärderat genom utläkning i ben och smärtlindring. Metod: En systematisk litteraturöversikt gjordes i fyra databaser; PubMed, Cochrane Library, Web of Science och Scopus. Översikten utfördes enligt instruktioner från ”PRISMA checklist” och ”CRD’s guidance”. En kvalitetsbedömning gjordes av samtliga inkluderade publikationer.Resultat: Sökningen resulterade i 2 100 artiklar. Efter urvalsprocessen återstod tre artiklar som inkluderades i denna systematiska litteraturöversikt. Samtliga studier utvärderade olika typer av bisfosfonatbehandlingar – ibandronat, pamidronat och disodium clodronat. Den smärtlindrande effekten utvärderades i alla tre studierna och utläkningen av benet utvärderades i två av artiklarna. Konklusion: Behandling av icke-infektiös osteomyelit med bisfosfonater visar en reduktion av smärta. Dock är den smärtlindrande effekten beroende på typen av bisfosfonat. Resultaten gällande utläkningen av ben är tvetydiga och därför kan ingen konklusion gällande detta göras. Endast en artikel ansågs i kvalitetsgranskningen ha hög kvalitet. För att kunna ta fram tydliga, evidensbaserade riktlinjer gällande behandling av icke-infektiös osteomyelit behövs fler kliniska studier som håller hög kvalitet. Bisfosfonater verkar vara ett bra behandlingsalternativ av icke-infektiös osteomyelit. Ett alternativ till bisfosfonater, skulle kunna vara behandling med denosumab, som har liknande verkningsmekanism men kortare halveringstid. Dock krävs fortsatta studier inom detta område.Aim: To systematically review the literature of medical treatment alternatives of non-infectious chronic osteomyelitis in the jaws regarding bone healing and pain relief. Methods: A systematic literature search has been made in four databases; PubMed, Cochrane Library, Web of Science and Scopus. The review was performed with directions from the PRISMA checklist and CRD’s guidance. A quality assessment was made of the included studies.Results: The search resulted in 2 100 articles and after the selection process, only three articles were included in this review. The studies evaluated different types of bisphosphonates - ibandronate, pamidronate and disodium clodronate. The reduction of pain was evaluated in all three articles and the bone healing was assessed in two of the articles. Conclusion: Treatment of non-infectious osteomyelitis with bisphosphonates shows a reduction in pain. However, the pain-relieving effect is most probably dependent on the type of bisphosphonates. The results of bone healing assessed from Tc-scans are ambiguous and therefore no conclusion can be made. Only one article in this review was considered to have high quality in the quality assessment. To enable clear guidelines regarding treatment of non-infectious osteomyelitis, more clinical trials with high quality is desirable. In summary, bisphosphonates seem to be a good alternative in treatment of non-infectious osteomyelitis. An alternative to bisphosphonates might be treatment with denosumab, which have a similar mechanism of action but shorter half-life. However, further research is needed.
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Suen, Ka-shing, and 孫嘉誠. "A prospective study of changes in psychosocial characteristics of patients with dentofacial deformities after corrective surgery." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hub.hku.hk/bib/B50639675.
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Background: Jaw corrective surgery can cause significant psychosocial impacts on patients. This prospective study aimed to investigate the longitudinal changes of psychosocial characteristics of patients with dentofacial deformities after corrective surgery and the factors that predict the psychological resilience of Hong Kong Chinese undergoing this type of surgery.
Materials and Methods: A prospective cohort study was carried out from 1st June 2011 to 31st December 2012 on Hong Kong Chinese patients, who had corrective surgery as treatment for their dentofacial deformities. Self-completed questionnaires, including Brief Symptom Inventory (BSI), Adult Trait Hope Scale (AHS), Hospital Anxiety and Depression Scale (HADS), Life Orientation Test (LOT), Social Avoidance and Distress Scale (SADS) and Satisfaction with Life Scale (SWLS), were administered to each patient at the surgical consent signing date (T1), one pre-operative day (T2), 1-2 post-operative week (T3) and 3rd post-operative month (T4). Psychological outcome trajectories were established using the BSI General Severity index (GSI) at T1, T3 and T4. Five patterns of outcome trajectories were created using specified outcome measures of psychological distress level, including chronic dysfunction, recovery, delayed dysfunction, resilience and others. They were then categorized into two patterns of outcome trajectories (resilience and non-resilience groups) for analysis. Independence sample t-test and logistic regression analyses were conducted to investigate the significance of life orientation level at baseline to predict resilience.
Results: 67 participants (23 males, 44 females; mean age 25.6) were recruited in the study. Highest hope level and psychological distress level was noted pre-operatively at the surgical consent signing date. The levels then dropped post-operatively in the first 3 months. No statistically significant difference was noted on the depression and anxiety level, social avoidance and distress level, optimism level and life satisfaction level from pre-operative to post-operative stages. The proportion of the five patterns of outcome trajectories was chronic dysfunction (22.4%), recovery (7.5%), delayed dysfunction (3%), resilience (43.3%) and others (23.8%). The logistic regression analyses showed that the pre-operative baseline optimism level of LOT was a significant predictor on the resilience characteristic of a patient after orthognathic corrective surgery.
Conclusion: Patients with dentofacial deformities have high level of hope and equally high level of psychological distress at the surgical consent stage of orthognathic surgery. Their psychological distress and hope levels tend to drop during the first three post-operative months. There is no expected peri-operative change on the depression and anxiety symptoms, social avoidance and distress, optimism level as well as life satisfaction level in these patients. Optimism level can predict the psychological resilience of a Hong Kong Chinese in going through orthognathic surgery. Brief Symptom Inventory (BSI) and Life Orientation Test (LOT) are recommended as preoperative psychological screening tools.published_or_final_version
Dental Surgery
Master
Master of Dental Surgery
26
Chan, Siew-luen. "A cephalometric study of dentoalveolar hyperplasia in dentofacial deformities." [Hong Kong] : University of Hong Kong, 1994. http://sunzi.lib.hku.hk/hkuto/record.jsp?B14019930.
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Steeve, Roger William. "Mandibular motor control during the early development of speech and nonspeech behaviors /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/8220.
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Mello, Patrícia Bicalho de [UNESP]. "Estabilidade esquelética da multisegmentação maxilar." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/123837.
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O objetivo desse estudo foi colaborar com o conhecimento atual sobre a estabilidade da multisegmentação maxilar que é controverso na literatura. Foram estudados aspectos relacionados à estabilidade esquelética, verificando-se possíveis relações da instabilidade com a amplitude dos movimentos cirúrgicos realizados, direção dos movimentos cirúrgicos realizados, tempo de acompanhamento e idade. TCFC digitalizadas antes e após cirurgia ortognática com osteotomia maxilar em forma de Y em 3 segmentos de 30 indivíduos em três momentos distintos foram analisadas (T1-pré-cirurgia; T2-pós-cirurgia imediata e T3- mínimo de 11 meses de acompanhamento). Os volumes tomográficos pré e póscirúrgicos foram superpostos, utilizando a base do crânio como referência para todos pacientes. Após a segmentação da maxila foi realizada a quantificação dos deslocamentos entre os modelos nos diferentes momentos por ICP (iterative closest point). Os valores médios dos deslocamentos e seus respectivos intervalos de confiança foram determinados por reamostragem não paramétrica; Man-Whitney para comparações duplas e Kruskal-Wallis para comparações múltiplas. Para as medidas de correlação, o coeficiente de correlação de Spearman foi calculado. Quanto maior a amplitude do deslocamento maior a instabilidade; a correlação da instabilidade com idade e tempo de acompanhamento foram muito pequenas...(Resumo completo, clicar acesso eletrônico abaixo)
The present study was undertaken to collaborate with up to date knowledge about the stability of maxillary multisegmentation that presents itself quite controversially in literature. Aspects related to skeletal stability were studied verifying the possible involvement of instability with the extent and direction of surgical movements performed and age. CBCT scanned before and after orthognathic surgery with maxillary osteotomy Y-shaped in 3 segments of 30 subjects at three different times were analyzed ( T1 - pre-surgery, T2 - immediate post operative and T3 - at least 11 months follow up) . Pre and postoperative CT volumes were superimposed using the base of the skull as a reference for all patients. After segmenting the maxilla, quantification of displacements between models at different moments was performed. The mean values of the desplacements and their respective confidence intervals were determined by nonparametric resampling; Man-Witney for double comparisons and Kruskal-Wallis for multiple comparisons. To measure the correlation, Spearman coefficient was calculated. As the displacement increase the instability increase; the correlation of instability with age and follow-up were very small.
29
Venkatesh, Lakshmi. "Speech movement characteristics of repetitive syllable production in children with speech disorders of unknown origin /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8264.
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Li, Kin-shing. "Relation of hypotension anaesthesia to blood loss during othrognathic [sic] surgery." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2232947X.
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Mello, Patrícia Bicalho de. "Estabilidade esquelética da multisegmentação maxilar /." Araraquara, 2014. http://hdl.handle.net/11449/123837.
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Orientador: João Roberto GonçalvesBanca: Alexandre Fortes Drummond
Banca: Rita de Cássia Moura Carvalho Lauris
Banca: Luiz Gonzaga Gandini Junior
Banca: Ary dos Santos Pinto
Resumo: O objetivo desse estudo foi colaborar com o conhecimento atual sobre a estabilidade da multisegmentação maxilar que é controverso na literatura. Foram estudados aspectos relacionados à estabilidade esquelética, verificando-se possíveis relações da instabilidade com a amplitude dos movimentos cirúrgicos realizados, direção dos movimentos cirúrgicos realizados, tempo de acompanhamento e idade. TCFC digitalizadas antes e após cirurgia ortognática com osteotomia maxilar em forma de Y em 3 segmentos de 30 indivíduos em três momentos distintos foram analisadas (T1-pré-cirurgia; T2-pós-cirurgia imediata e T3- mínimo de 11 meses de acompanhamento). Os volumes tomográficos pré e póscirúrgicos foram superpostos, utilizando a base do crânio como referência para todos pacientes. Após a segmentação da maxila foi realizada a quantificação dos deslocamentos entre os modelos nos diferentes momentos por ICP (iterative closest point). Os valores médios dos deslocamentos e seus respectivos intervalos de confiança foram determinados por reamostragem não paramétrica; Man-Whitney para comparações duplas e Kruskal-Wallis para comparações múltiplas. Para as medidas de correlação, o coeficiente de correlação de Spearman foi calculado. Quanto maior a amplitude do deslocamento maior a instabilidade; a correlação da instabilidade com idade e tempo de acompanhamento foram muito pequenas...(Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The present study was undertaken to collaborate with up to date knowledge about the stability of maxillary multisegmentation that presents itself quite controversially in literature. Aspects related to skeletal stability were studied verifying the possible involvement of instability with the extent and direction of surgical movements performed and age. CBCT scanned before and after orthognathic surgery with maxillary osteotomy Y-shaped in 3 segments of 30 subjects at three different times were analyzed ( T1 - pre-surgery, T2 - immediate post operative and T3 - at least 11 months follow up) . Pre and postoperative CT volumes were superimposed using the base of the skull as a reference for all patients. After segmenting the maxilla, quantification of displacements between models at different moments was performed. The mean values of the desplacements and their respective confidence intervals were determined by nonparametric resampling; Man-Witney for double comparisons and Kruskal-Wallis for multiple comparisons. To measure the correlation, Spearman coefficient was calculated. As the displacement increase the instability increase; the correlation of instability with age and follow-up were very small.
Doutor
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Shiller, Douglas M. "Understanding speech motor control in the context of orofacial biomechanics." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84435.
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A series of experiments are described which explore the relationship between biomechanical properties and the control of jaw movement in speech. This relationship is documented using kinematic analyses in conjunction with a mathematical model of jaw motion and direct measures of jaw stiffness.In the first experiment, empirical and modeling studies were carried out to examine whether the nervous system compensates for naturally occurring forces acting on the jaw during speech. As subjects walk or run, loads to the jaw vary with the direction and magnitude of head acceleration. While these loads are large enough to produce a measurable effect on jaw kinematics, variation in jaw position during locomotion is shown to be substantially reduced when locomotion is combined with speech. This reduction in jaw motion is consistent with the idea that in speech, the control of jaw movement is adjusted to offset the effects of head acceleration. Results of simulation studies using a physiologically realistic model of the jaw provide further evidence that subjects compensate for the effects of self-generated loads by adjusting neural control signals.
A second experiment explores the idea that a principle mechanical property of the jaw---its spring-like behavior, or stiffness---might influence patterns of kinematic variation in speech movements. A robotic device was used to deliver mechanical perturbations to the jaw in order to quantify stiffness in the mid-sagittal plane. The observed stiffness patterns were non-uniform, with higher stiffness in the protrusion-retraction direction. Consistent with the idea that kinematic patterns reflect directional asymmetries in stiffness, a detailed relationship between jaw kinematic variability and stiffness was observed---kinematic variability was consistently higher under conditions in which jaw stiffness was low. Modeling studies suggested that the pattern of jaw stiffness is significantly determined by jaw geometrical properties and muscle force generating abilities.
A third experiment examines the extent to which subjects are able to alter the three-dimensional pattern of jaw stiffness in a task-dependent manner. Destabilizing loads were applied to the jaw in order to disrupt the ability of subjects to maintain a static jaw posture. Subjects adapted by increasing jaw stiffness in a manner that depended on the magnitude and, to a more limited extent, direction of the destabilizing load. The results support the idea that stiffness properties can be controlled in the jaw, and thus may play a role in regulating mechanical interactions in the orofacial system.
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Shiller, Douglas M. "Compensation for the gravitational force on the jaw during speech." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0003/MQ43949.pdf.
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Li, Kin-shing, and 李健誠. "Relation of hypotension anaesthesia to blood loss duringothrognathic [sic] surgery." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31954121.
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Brozoski, Mariana Aparecida. "Efeito de diferentes concentrações do alendronato sódico sobre a viabilidade e proliferação de diferentes tipos celulares em cultura." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/23/23149/tde-20092011-162508/.
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Os bisfosfonatos têm sido indicados para o tratamento de doenças ósseas líticas. Atualmente, seu emprego terapêutico aumentou e com ele os efeitos adversos, sendo um dos mais importante a indução da osteonecrose dos maxilares, uma complicação de difícil tratamento e solução. Até o presente, não se sabe ao certo qual o mecanismo de desenvolvimento da osteonecrose e nem qual deve ser o melhor tratamento estabelecido perante essa manifestação. Este trabalho teve como objetivo avaliar o efeito do alendronato sódico sobre a viabilidade e proliferação de osteoblastos e fibroblastos em cultura. Foram utilizados osteoblastos-símile linhagem OSTEO 1 e fibroblastos de mucosa bucal humana linhagem FMM1. Após serem submetidos aos testes de citotoxicidade com concentrações do alendronato sódico variando de 10-2M a 10-8M os fibroblastos apresentaram diminuição significante de viabilidade celular apenas na concentração de 10-2M (p<0,01). Os osteoblastos demonstraram viabilidade celular no grupo controle significantemente maior que todos os demais grupos; o grupo tratado com o alendronato na concentração de 10-4M apresentou viabilidade celular semelhante a de todos os grupos, exceto o grupo de concentração 10-2M e a viabilidade celular dos demais grupos foi semelhante entre si (p<0,01). As concentrações de alendronato sódico superiores a 10-5M impediram a proliferação dos osteoblastos. Foi possível concluir que o alendronato sódico é citotóxico para células osteoblastos-símile e fibroblastos em cultura em função de sua concentração. Os fibroblastos são menos sensíveis a concentrações maiores de alendronato sódico que os osteoblastos.Bisphosphonates have been therapeutically used for the management of lytic bone diseases. Their use has been increased nowadays and besides that associated adverse effects have been amplified. Jaw osteonecrosis induced by this drug is perhaps the most important complication because of the great morbidity and difficulty to deal with. Until now the physiopathology of osteonecrosis remains unclear and the treatment that should be established is uncertain. This study aimed to evaluate the effect of sodium alendronate a bisphosphonate used for the treatment of osteoporosis on the viability and proliferation of osteoblasts and fibroblasts in culture. Osteoblast-simile from the lineage OSTEO1 and a human oral mucosa fibroblasts from the lineage FMM1 were used. After being subjected to tests with concentrations of sodic alendronate ranging from 10-8M to 10-2M fibroblasts showed a significant decrease in cell viability at the concentration of 10-2M (p < 0.01). Osteoblasts showed that the cell viability in the control group was significantly higher than all other groups, the group treated with alendronate at a concentration of 10-4M had similar cell viability with all groups except the group of 10-2M concentration and the cell viability of other groups was similar between groups (p < 0.01). The concentrations of alendronate greater than 10-5M prevented the proliferation of osteoblasts. It was possible to conclude that alendronate is cytotoxic to osteoblast-símile cells and fibroblasts in culture due to its concentration. The fibroblasts are less sensitive to higher concentrations of alendronate than osteoblasts.
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Laparidis, Con. "A retrospective cephalometric study of the effect of the Fränkel appliance, the ClarkTwin Block and the activator on class II division /." Title page, contents and summary only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phl299.pdf.
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Abreu, Marcos Petto Nunes de. "Avaliação do uso da ultrassonografia modo B para exploração através de tecido ósseo de costelas bovinas." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/23/23139/tde-14012013-153719/.
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O uso da ultrassonografia, para diagnóstico, como forma de exame complementar na área da Saúde é cotidiano e consagrado, principalmente no estudo e avaliação das doenças em tecidos moles. Com a consolidação e o desenvolvimento deste método, novos usos vem sendo descritos. Existem relatos científicos da possibilidade do uso do ultrassom para avaliação de lesões no interior do tecido ósseo. Frente a esta alternativa, o presente estudo avaliou o uso da ultrassonografia para exploração através de tecido ósseo, de diferentes espessuras, com a utilização de um modelo laboratorial em costelas bovinas, definindo a espessura óssea cortical que permite a passagem do ultrassom. Primeiramente realizamos um ensaio experimental para definir a melhor metodologia para o estudo. O modelo laboratorial usado era constituído por uma costela bovina, macerada, desgastada em diferentes espessuras. A amostra do estudo foi constituída em 180 leituras de ultrassom provenientes de 20 costelas bovinas maceradas; onde cada uma delas foi examinada em 9 áreas que se diferenciavam na espessura do remanescente ósseo; assim definidas 4,0mm, 3,0mm, 2,5mm, 2,0mm, 1,5mm, 1,0mm, 0,5mm, 0,2mm e sem desgaste. Para os exames de ultrassom foi utilizado o aparelho de ultrassom portátil Terason t3000 (Terason, divisão da Teratech Corporation, USA). Os exames foram realizados pela técnica da imersão, onde se mergulhava os espécimes e o transdutor do ultrassom em um recipiente com água. Para avaliar se havia ou não passagem da onda de ultrassom pelo tecido ósseo, em uma determinada espessura, era observada a formação de imagem de um objeto metálico posicionado atrás do osso. Conforme observado pela tabulação dos resultados ocorreu a passagem das ondas de ultrassom através do osso de espessuras 2,0mm, 1,5mm, 1,0mm, 0,5mm e 0,2mm diferentemente do ocorrido nas espessuras 4,0mm, 3,0mm, 2,5mm e sem desgaste. Houve diferença estatisticamente significante (P<0,001) entre as espessuras menores ou iguais a 2,0mm e as espessuras maiores ou iguais a 2,5mm, quanto a formação de imagem ultrassonográfica de um objeto metálico posicionado atrás do tecido ósseo. Concluímos que houve possibilidade de utilização do exame de ultrassom na avaliação através do tecido ósseo de espessuras menores ou iguais a 2,0mm.The use of ultrasound as a complementary examination in health diagnoses is something usual and well established, mainly in the study and evaluation of diseases in soft tissue. As the consolidation and development of this method ocourred, new uses for it has been described. There are scientific reports with the possibility of the use of ultrasound for the evaluation of lesions within the bone tissue. Faced with this alternative, the aim of the present study was to evaluate the use of ultrasound for exploration through the bone tissue of different thicknesses, using a laboratory model of beef ribs, so thath would be defined the minimum required thicknesses of cortical bone for passage of the ultrasound. First we conducted an experimental trial to determine the best methodology for the study. The laboratory model used consisted of beef ribs prepared in different thicknesses. The study sample consisted of 180 ultrasound readings from 20 macerated beef ribs, each of which was examined in 9 different areas defined as, no wear, 4.0 mm, 3.0 mm, 2.5 mm, 2.0 mm, 1.5mm, 1.0mm, 0.5mm and 0.2mm in thicknesses of the remaining bone. For ultrasound scanning was used a portable ultrasound device, Terason t3000 (Terason, a division of Teratech Corporation, USA). The examinations were performed by the technique of immersion, where the specimens and the ultrasound transductor were immersed in a water tank. To assess whether there was passage of ultrasound waves by the bone tissue in a certain thickness, it was observed the occurrence of a image formation from a metallic object that was positioned behind the bone. As noted by tabulating the results, there was passage of ultrasound waves through the bone thickness 2.0mm, 1.5mm, 1.0mm, 0.5mm and 0.2mm different from those occurred in thickness of 4.0mm, 3.0mm, 2.5mm and no wear. There was significant difference (P<0.001) between the thicknesses less than or equal to 2.0 mm and thickness greater than or equal to 2.5 mm, in the ultrasound imaging of a metallic object positioned behind the bone. We conclude that there was possibility of using the ultrasound examination in the evaluation through the bone thickness less than or equal to 2.0mm.
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Strong, Edward Trowbridge. ""The Jaws of Mars are Traditionally Wide ... And His Appetite Is Insatiable": Truman, the Budget, and National Security." Miami University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=miami1564568978026948.
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Lau, Sze-lok Alfred. "Evidence-based practice in oral and maxillofacial surgery /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B32222154.
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Ling, Paul H. "Orthopaedic and orthodontic treatment effects using the Clark Twin Block functional appliance : a retrospective cephalometric study of patients with class II malocclusions : a report submitted in partial fulfilment of the requirements for the degree of Master of Dental Surgery /." Title page, contents and summary only, 1998. http://web4.library.adelaide.edu.au/theses/09DM/09dml755.pdf.
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Thompson, Leesa M. "Satisfaction with pain mangement for adolescence and anxiety." Muncie, Ind. : Ball State University, 2009. http://cardinalscholar.bsu.edu/626.
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Maceinaitė, Eglė. "Balso technologijų adaptavimas lietuviškai kalbantiems asmenims su regėjimo negalia." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20101125_190808-49553.
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Šiame darbe nagrinėjamas balso technologijų adaptavimas lietuviškai kalbantiems asmenims su regėjimo negalia. Tiriamas lietuviškų internetinių puslapių pritaikymas akliesiems ir silpnaregiams, naudojantis ekrano skaitytuvu „Jaws for Windows“. Darbo tikslas – ištirti naudojamų kalbos technologijų taikymų adaptavimo galimybes, lietuviškai kalbančiam neįgaliam asmeniui. Darbo uždaviniai: 1. Išsiaiškinti balso technologijų taikymų neįgaliesiems svarbą; 2. Išnagrinėti programinę ir techninę balso technologijų neįgaliesiems taikymo įrangą; 3. Ištirti ekrano skaitytuvo „Jaws for Windows“ funkcionalumą ir vartotojiškumą; 4. Įvertinti kiek Lietuva yra pasiruošusi internetinių puslapių neįgaliesiems kūrime ir naudojime; 5. Pasiūlyti priemones, internetinių svetainių akliesiems ir silpnaregiams, kūrimui ir naudojimui. Darbe naudotini metodai: literatūros analizė ir apibendrinimas, empirinis-eksperimentinis bandymas bei lyginamoji analizė. Išvados: 1. Darbe išsiaiškinta, kad balso technologijų taikymai neįgaliesiems yra esminis jų integravimo į visuomenę elementas. 2. Nustatyta, kad didžiausias yra techninės įrangos pasirinkimas kurtiesiems ir neprigirdintiems, tačiau programinės įrangos didžiausia rinka yra skirta akliesiems ir silpnaregiams. 3. Išsiaiškinta, kad „Jaws for Windows“ ekrano skaitytuvas yra tarptautinis ekrano skaitytuvų standartas akliesiems ir silpnaregiams. 4. Ištirtas ekrano skaitytuvo „Jaws for Windows“ funkcionalumas ir vartotojiškumas, nustatyta, kad programa daro... [toliau žr. visą tekstą]This paper considers the adaptation of voice technologies for Lithuanian visually impaired persons. Studied Lithuanian popular websites use of blind and partially sighted people, using a screen reader "JAWS for Windows." The aim of work – explore adaptation of speech technologies applications oriented for disabled Lithuanian people. The tasks of work: 1. To clarify the importance of speech technologies applications oriented for disabled people; 2. Examine the software and the hardware of speech technologies oriented for disabled people; 3. Examine the screen scanner „Jaws for Windows“ functionality and consumption; 4. Assess how Lithuania is ready to develop and to use websites for disabled people; 5. To propose measures for creation and use websites for blind and partially sighted people. The work methodology: Analysis and synthesis of the literature, empirical test-experimental and comparative analysis. Conclusions: 1. Recognition of the work that the voice technology applications for disabled people are essential to their way of integration into society. 2. Clear that the „Jaws for Windows“ screen reader is an international standard of screen readers for blind and sighted people. 3. Studied the screen reader „Jaws for Windows“ functionality and consumption, found that the program has twice as many errors, in reading the most popular Lithuanian sites, than those recommended by the American Association for the blind and sighted. 4. Experimental study of the proposal to... [to full text]
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Filho, Edson Virgilio Zen. "Análise molecular e microscópica do reparo ósseo de alvéolos dentários após exodontia em um modelo de osteonecrose dos maxilares induzida pelo ácido zoledrônico em ratos Wistar." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/25/25149/tde-08092014-103848/.
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O reparo ósseo de alvéolos após exodontia dos molares superiores em um modelo animal em ratos Wistar (Rattus norvegicus, albinus) de osteonecrose dos maxilares associada ao uso de bisfosfonatos foi avaliado através de analise microscópica e molecular. Foram utilizados 48 ratos (Rattus norvegicus, albinus, Wistar) machos, com 12 semanas de vida e peso aproximado de 300 gramas, que foram dividos em 4 grupos. Cada grupo era composto por 12 animais, sendo 2 grupos experimentais AZ e AZ-Cirúrgico (AZ-C), que foram submetidos a administração de ácido zoledrônico, 0,6 mg/kg a cada 28 dias com um total de 5 doses e 2 grupos controles CO e CO-Cirúrgico (CO-C) com administração de cloreto de sódio 0,9% no mesmo volume e frequencia do ácido zoledrônico. Todas as soluções foram administradas por via intraperitoneal. O grupo AZ-C e o grupo CO-C foram submetidos a exodontia do primeiro, segundo e terceiro molares superiores 45 dias após a primeira aplicação das soluções. Todos os animais foram eutanasiados após 150 dias do início do experimento (105 dias após as exodontias). As maxilas dos animais foram avaliadas macroscopicamente para presença de lesões espontâneas e com uma sonda clinica número 5 as regiões das exodontias dos molares foram avaliadas para presença ou ausência de solução continua do epitélio. Após feita a avaliação macroscópica as regiões das exodontias dos molares superior esquerdo e do lado contralateral de cada animal foram submetidas a análises qualitativa e quantitativa para presença de sequestros ósseos, restos radiculares, área de osteonecrose, área de espaço trabecular, área de reação periosteal, através de estudos por microscopia óptica pela coloração Hematoxilina e Eosina. Análise quantitativa da expressão do RNAm de proteínas envolvidas no processo de reparo ósseo RANK, RANKL, OPG e VEGF, pelo método de reação em cadeia da polimerase em tempo real (RealTimePCR) também foi realizada. A avaliação macroscópica mostrou que 91,66% dos animais do grupo AZ-C e 41,66% do grupo CO-C apresentaram solução de continuidade do epitélio, sendo estatisticamente significante maior no grupo em terapia com ácido zoledrônico pelo este exato de Fischer (p<0,05). Todos animais do grupo AZ-C e nenhum do grupo CO-C apresentaram sequestros ósseos e todos os animais apresentaram presença de restos radiculares na análise microscópica. A área de osteonecrose foi maior nos animais do grupo AZ-C do que no grupo CO-C (p<0,005), não havendo diferença estatística entre as áreas de espaço trabecular, reação periosteal e osso total. Na análise molecular de RANK, RANKL, OPG e VEGF não houve diferença estatisticamente significante entre os grupos CO, AZ, COC e AZ-C, mesmo quando comparadas áreas de exodontia com áreas com dentes. Estes resultados levam a conclusão que o modelo animal utilizado no presente estudo é um modelo seguro, que o ácido zoledrônico interferiu no reparo ósseo dos alvéolos, causando um atraso na remodelação óssea da região e uma maior incidência de osteonecrose e sequestros ósseos. O ácido zoledrônico não afetou a expressão de RANK, RANKL, OPG e VEGF 105 dias após as exodontias.The alveolar bone repair following extraction of maxillary molars in an animal model of bisphosphonate related osteonecrosis of the jaws in Wistar rats (Rattus norvegicus, Albinus) was assessed through microscopic and molecular analysis. A total of 48 rats (Rattus norvegicus, Albinus, Wistar rats) with 12 weeks old and weighing approximately 300 grams were used, they were divided into 4 groups. Each group consisted of 12 animals, with 2 experimental groups AZ and AZ-Cirúrgico (AZ-C), who underwent the administration of zoledronic acid, 0.6 mg / kg every 28 days with a total of 5 doses. And 2 control groups CO and CO-Cirúrgico (CO-C) with administration of sodium chloride at 0.9% in the same volume and frequency of zoledronic acid. All solutions were administered intraperitoneally. The group AZ-C and CO-C underwent to extraction of the first, second and third molars 45 days after the first application of the solutions. All animals were sacrificed after 150 days from the beginning of the experiment (105 days after extractions). The maxilla of the animals were assessed macroscopically for the presence of spontaneous lesions, and with a clinical probe number five the regions of the molar extractions were evaluated for the presence or absence of loss of continuity of the oral epithelium. After macroscopic evaluation, the upper left molar and contralateral side of the extraction regions of each animal were submitted to qualitative and quantitative analyzes for the presence of bone sequestrum, root fragments, osteonecrosis area, trabecular space area, area of periosteal reaction, through optical microscopic studies by hematoxylin and eosin staining. And quantitative analysis of mRNA expression of proteins involved in bone repair (RANK, RANKL, OPG and VEGF), by the method of RealTimePCR were carried out. Macroscopic evaluation showed that 91.66% of the AZ -C group and 41.66% of the CO-C group presented a loss of continuity of the epithelium, which was statistically significant higher in the zoledronic acid group according to the Fisher test (p<0.05). All animals in group AZ-C and none in CO-C group showed bone sequestrum and all animals in both groups had root fragments in microscopic analysis. The area of osteonecrosis was higher in the animals of AZ-C group than in CO-C (p<0.005), with no statistical difference between the areas of trabecular space, periosteal reaction and total bone. In the molecular analysis of RANK, RANKL, OPG e VEGF there was no statistically significant difference between the CO, AZ, CO-C e AZ-C groups, even when extraction regions were compared to non extractions areas. These results lead to the conclusion that the animal model described used in this study is a reliable model and zoledronic acid interferes with alveolar bone repair causing a delay in bone emodeling and a higher incidence of osteonecrosis and bone sequestrum. Zoledronic acid did not affect the expression of RANK, RANKL, OPG and VEGF 105 days after dental extractions.
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Cabral, Jefry Alberto Vargas. "Estudo de coorte prospectivo do padrão ósseo alveolar em mulheres eutróficas e obesas antes e após a cirurgia bariátrica." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/25/25144/tde-22062017-211601/.
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O tecido adiposo pode regular o metabolismo ósseo e estar envolvido na fisiopatologia da osteoporose, sendo este fator determinante no sucesso de tratamentos reabilitadores com implantes dentários osseointegrados. O presente estudo de coorte prospectivo teve como objetivo verificar o padrão ósseo alveolar por meio de índices radiomorfométricos da radiografia panorâmica e medidas lineares realizadas em radiografias periapicais, em pacientes eutróficas e obesas mórbidas antes e após a cirurgia bariátrica. A amostra foi constituída por 31 mulheres com idade de 20 a 35 anos, sendo divididas em 2 grupos: Grupo Experimental (GE-Obesas de Grau III, IMC >40 Kg/m2) e Grupo Controle (GC- Eutróficas, IMC 18,5 a 24,99 Kg/m2). Foram avaliadas 20 eutróficas e 11 obesas mórbidas no pré e pós-cirurgia bariátrica (6 meses). Índices radiomorfométricos e de placa dentária foram avaliados nos tempos T0 (baseline) e T1 (6 meses). Na análise radiográfica foram avaliados o padrão trabecular através da escada visual de Lindh e a perda óssea por meio do cálculo da distância da junção cemento-esmalte à crista óssea, em radiografias periapicais. Já as radiografias panorâmicas para mensurar Índice da Cortical Mandibular (ICM), Índice Mentoniano (IM) e Índice Panorâmico Mandibular (IPM), além do índice de Placa de Turesky. Houve perda óssea significativa em T1 nas pacientes submetidas à cirurgia bariátrica, quando comparada com as eutróficas (p<0,05). O padrão trabecular tornou-se mais esparso após a cirurgia apresentando uma diferença visual. No índice de placa foi observada uma ligeira melhora após a cirurgia e os eutroficos mantiveram valores similares ao longo do tempo. Pode-se concluir que pacientes obesas apresentam maior perda óssea, a qual piora após a cirurgia bariátrica, quando comparada com o de pacientes eutróficas. O mesmo acontecendo com o trabeculado ósseo que se torna mais esparso após a cirurgia bariátrica.Adipose tissue can regulate bone metabolism and be involved in the pathophysiology of osteoporosis, being this determinant factor in the success of rehabilitative treatments with osseointegrated dental implants. The present prospective cohort study aimed to verify the alveolar bone pattern through radiomorphometric indices of panoramic radiography and linear measurements performed in periapical radiographs in eutrophic and morbidly obese patients before and after bariatric surgery. The sample consisted of 31 women aged 20-35 years old, divided into 2 groups: Experimental Group (GE-Obesas de Grade III, BMI> 40 Kg / m2) and Control Group (GC-Eutrophic, BMI 18.5 To 24.99 kg / m2). 20 eutrophic and 11 obese morbidities were evaluated in the pre and postoperative bariatric surgery (6 months). Radiomorphometric and plaque indices were evaluated at T0 (baseline) and T1 (6 months) times. In the radiographic analysis the trabecular pattern through the Lindh visual ladder and the bone loss were evaluated by calculating the distance from the cemento-enamel junction to the bone crest in periapical radiographs. Panoramic radiographs were used to measure the Mandibular Cortical Index (ICM), Mentonian Index (IM) and Panoramic Mandibular Index (MPI), in addition to the Turesky Plate index. There was a significant loss of bone in T1 in patients submitted to bariatric surgery, when compared to eutrophic patients (p <0.05). The trabecular pattern became more sparse after surgery with a visual difference. The plate index showed a slight improvement after surgery and the eutrophic maintained similar values over time. It can be concluded that obese patients present greater bone loss, which worsens after bariatric surgery, when compared to that of eutrophic patients. The same happens with the trabecular bone that becomes more sparse after bariatric surgery.
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Silva, Luis Felipe Oliveira e. "Desenvolvimento e avaliação de um sistema de cálculo de dose independente para controle de qualidade de IMRT do tipo jaws-only." reponame:Repositório Institucional da UnB, 2015. http://dx.doi.org/10.26512/2015.10.D.20724.
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Dissertação (mestrado)—Universidade de Brasília, Faculdade Gama, Programa de Pós-Graduação em Engenharia Biomédica, 2015.Submitted by Fernanda Percia França (fernandafranca@bce.unb.br) on 2016-06-06T17:55:07Z No. of bitstreams: 1 2015_LuisFelipeOliveiraeSilva.pdf: 5470471 bytes, checksum: 1fe65af174596febff5a94a7a05ae399 (MD5)
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A radioterapia de intensidade modulada (IMRT, do inglês intensitymodulatedradiotherapy) proporciona distribuições de dose bastante complexas, com regiões de alto gradiente de dose. Essa complexidade representa um desafio maior no controle de qualidade (CQ) quando se compara a IMRT com a radioterapia convencional. O objetivo do presente trabalho foi desenvolver e avaliar um sistema de cálculo de dose independente, chamado SCI, para o controle de qualidade da IMRT do tipojawsonly. O software desenvolvido utiliza um algoritmo de cálculo de dose baseado em correções realizadas no fator de calibração do acelerador linear, por meio de fatores tabelados, derivados de medições e calculados a partir de simples modelagem. Os próprios dados gerados no comissionamento são usados para alimentar o algoritmo.Os cálculos são realizados em um plano de um fantoma retangular. Para validar o SCI, comparações entre as previsões dosimétricas do sistema e outras referências foram realizadas. Foram comparados: doses pontuais no centro de campos assimétricos medidos com câmara de ionização; perfis de campos medidos com filme radiocrômico e com câmara de ionização; distribuições planares de dose de cinco casos de câncer de próstata e cinco de cabeça e pescoço medidas com um arranjo bidimensional de câmaras de ionização e calculadas pelo sistema de planejamento de tratamento (SPT). A avaliação foi realizada utilizando diferenças percentuais de dose, a menor diferença de posição em que se encontra o mesmo valor de dose (DTA, do inglês distancetoagreement) e a avaliação gama com critérios: (i) diferença máxima de dose de 3%, DTA de 3 mm; (ii) diferença máxima de dose 5%, DTA de 3 mm; e (iii) diferença máxima de dose 5%, DTA de 5 mm. As diferenças encontradas nas comparações entre as doses obtidas no centro de campos assimétricos foram menores do que 2,5%.As diferenças nos perfis dos campos quadrados menores do que 30x30 cm2 foram menores do que 2% ou 2mm. Os campos menores, medidos com filme, apresentaram diferenças mais consideráveis (DTAs de até 5 mm foram observadas). Esse resultado já era esperado devido à maior resolução espacial do filme quando comparada à da câmara de ionização (volume sensível de 0,125 cc). As avaliações gama usando tanto as medições quanto o SPT como referência sugerem que o SCI representa a distribuição de dose real segundo o critério de 5% de diferença máxima de dose e 5 mm de DTA, uma vez que a média de pontos aprovados foi superior a 96,5% (p<0,001) em todos os casos quando esse critério foi utilizado. O sistema também apresenta um boa representação segundo o critério de 5% de diferença máxima de dose e 3 mm de DTA (média de pontos aprovados superior a 92,0%; p<0,01). As médias de pontos aprovados com esses dois critérios estão, portanto, de acordo com os valores tipicamente usados como referência por profissionais da área de radioterapia. Desta forma, o sistema desenvolvido no presente trabalho está pronto para ser utilizado para o CQ de IMRT do tipo jawsonly sem custo adicional em relação aos equipamentos já utilizados, reduzindo o fluxo de trabalho comparado a métodos mais tradicionais e sem ocupação adicional da máquina de tratamento.
Intensity modulated radiation therapy (IMRT) provides complex dose distributions with high dose gradient regions. This complexity is a major challenge for quality assurance (QA), specially when comparing IMRT with conventional radiotherapy. In this research, I propose, develop, and evaluate an independent dose calculation system for QA of jaws only IMRT (JOIMRT). The developed software uses a dose calculation algorithm based on corrections performed over the linear accelerator (linac) calibration factor. In order to perform this corrections I used tabulated factors derived from measurements and calculated from simple modeling. Also, I used the linac's commissioning data as input to the algorithm.The developed system then performs the main computations over a rectangular phantom plan. To validate the proposed system, I compared the predictions of the dosimetric system with references that are commonly used in the literature. Specifically, I compared: point doses in the center of asymmetric field measured with an ionization chamber; dose profiles measured with radiochromic film and an ionization chamber; planar dose distributions of five of prostate and five head and neck cases measured with a two-dimensional array of ionization chambers and calculated by the treatment planning system (TPS). The evaluation was performed using percentage dose differences, distance to agreement (DTA) and gamma evaluation with tree criterions: (i) maximum difference dose of 3% and 3 mm DTA, (ii) maximum difference dose of 5% and 3 mm DTA, and (iii) maximum difference dose of 5% and 5 mm DTA. The differences in the comparisons between the doses obtained in the center of asymmetric fields were smaller than 2.5%. Differences in the profiles of square fields up to 30x30 cm2 were smaller than 2% or 2 mm. Smaller fields measured with film showed more significant differences (I measured DTAs up to 5 mm). This result was expected because of the higher spatial resolution of the film, as compared to the ionization chamber that provided the measurements used as inputs to the calculation algorithm (sensitive volume of 0.125 cc). The point approval ratings using both measurements and the TPS as a reference suggest that the independent dose calculation system represents the actual dose distribution according to the criterion of 5 % maximum dose difference and 5 mm DTA, since the average was approved points above 96.5% (<0,001) in all cases when this criterion was used. The system also features a good representation according to the criterion of 5% maximal dose difference and 3 mm DTA (average of approved points above 92.0%; p <0.01). Therefore, the average of approved points obtained with those two criteria satisfies the values typically used as references by radiotherapy professionals. In this way, the system I developed is ready to be used for the JOIMRT QA with no additional cost with respect to equipment already used, reducing the workload compared to more traditional methods and without additional treatment machine occupation.
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Handoo, Nidhi Q. "Analysis of bone activity of jaws using scintigraphy on patients before, during and after treatment with IV bisphosphonates: a retrospective study." Thesis, University of Iowa, 2009. https://ir.uiowa.edu/etd/240.
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Bisphosphonates are non-metabolized compounds with high affinity for bone mineral hydroxyapatite. These compounds are used in diagnosis and treatment of malignancies metastatic to bone. Currently, IV bisphosphonates are used to treat hypercalcemia of malignancy. There are also "off label" uses to prevent, minimize, or delay skeletal morbidity associated with metastatic bone disease. Osteonecrosis of the jaws is an intraoral complication that has been reported after administration of intravenous nitrogen-containing bisphosphonates. Bisphosphonate associated osteonecrosis (BON) may remain asymptomatic for many weeks or months and is usually recognized clinically by the identification of exposed bone in the oral cavity. Other clinical features of BON are pain, ulceration, necrotic bone and/or local inflammation of the mucosa. Though these are generally all of which are seen later in the disease process. It is theorized that nuclear medicine imaging may play a crucial role in the recognition and identification of these bone lesions earlier in the disease process. Due to the high bone affinity, bisphosphonates coupled to a gamma-emitting radioisotope have been used as bone-scanning agents. Technetium is most commonly used gamma-emitting radioisotope in conjunction with a bisphosphonate. In University of Iowa Hospitals and Clinics, the material of choice is technetium99 methylene diophosphonate (Tc99 MDP). Bisphosphonates have a long half-life in bone and long-term treatment with non-tagged therapeutic bisphosphonates may saturate bone adherence sites and interfering with a single-dose scanning agent used for bone scintigraphy. Alternatively, therapeutic bisphosphonates may alter bone physiology such that scintigraphic findings could be enhanced in some locations and decreased in others. Limitations of the use of scintigraphy in patients on bisphosphonate therapy include low resolution and a difficulty in differentiating between inflammation and metastatic disease especially during the latter stages of the disease. In an effort to understand the effects of this compound on scintigraphic imaging, this study will evaluate any potential changes during and after use of IV bisphosphonates that may confound imaging.
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Tenhunen, Katja, and Jannica Holm. "Webbhjälpmedel för synskadade." Thesis, Södertörn University College, School of Communication, Technology and Design, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-346.
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The purpose of this paper is to find out how visually impaired people get information on Internet. Visually impaired people has got the right to be able to use the Internet like everyone else. We are also going to revise which aids visually impaired people use today, and how they work in practise. What problems can you run into when you use these aids? We are also going to revise how the webpages design affect the use of the Internet for the visually impaired people. The sites of today tends to contain more and more graphics without alternative texts. The aids a visually impaired person use have problems to interpret the graphics, which leads to that many sites are inaccessible for this group of people . We have interviewed nine visually impaired and blind people to get insight in how they use the Internet and which aids are the most common and how they work in practise. We have come to the conclusion that a lot of visually impaired people today are very dependent of the Internet. These people use sites that they from their own experience knows works. The persons we have talked to told us that they feel that many sites are not adjusted to visually impaired people. At the same time we discovered that the technology to interpret graphics on the Internet actually exists. But this technology is not available since the eye clinics does not realise the importance of updating the aids more often.
Syftet med uppsatsen är att ta reda på hur de synskadade kan ta till sig information på Internet. Även de synskadade ska ha rätt till att kunna använda sig av Internet som alla andra. Vi ska också undersöka vilka webbhjälpmedel som finns till hands för de synskadade idag och hur dessa webbhjälpmedel fungerar i praktiken. Vilka problem som man kan stöta på när man använder sig av dessa webbhjälpmedel? Vi ska även undersöka hur mycket webbplatsernas utformning påverkar de synskadades Internetanvändning. Dagens webbplatser tenderar att använda mer och mer grafik utan alternativa texter. De hjälpmedel som en synskadad person använder har svårt att tolka detta, vilket leder till att många webbplatser är otillgängliga för denna grupp av människor. Vi har intervjuat nio synskadade och helt blinda personer för att få en inblick i hur de använder sig av Internet, vilka hjälpmedel som är vanliga och hur dessa hjälpmedel fungerar i praktiken. Vi kom fram till att synskadade idag är relativt beroende av Internet och att de använder sig av webbplatser på Internet som de känner till sedan tidigare. De personer som vi har talat med upplever att det är väldigt många webbplatser som inte är anpassade för synskadade personer. Samtidigt upptäckte vi att tekniken faktiskt finns som kan tolka grafiken på Internet, men att denna teknik inte är tillgänglig mycket beroende på att syncentralerna som delar ut dessa hjälpmedel inte inser vikten av att uppdatera dessa hjälpmedel oftare.
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Van, Heerden Willem F. P. "Pathology of the head and neck : a retrospective appraisal /." Access to E-Thesis, 2003. http://upetd.up.ac.za/thesis/available/etd-10052005-153741/.
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Thesis (D.Sc.(Odontology))--University of Pretoria, 2003."Published work submitted to the University of Pretoria for the degree of Doctor of Science in Odontology (Oral pathology)". Includes bibliographical references. Also available online.
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Connaghan, Kathryn P. "Jaw stiffness during speech by children with suspected hypo- or hypertonia /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/8206.
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Tartaroti, Natalia Caroline Aguiar. "Efeito de diferentes concentrações do Denosumab sobre a viabilidade, proliferação e migração de fibroblastos em cultura." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/23/23149/tde-12062017-164715/.
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Atualmente é crescente o número de pacientes utilizando drogas que visam a alteração da remodelação óssea. Doenças como osteoporose e tumores ósseos têm possibilidade de tratamento com a utilização dos antirreabsortivos. Entretanto tais medicamentos apresentam, entre outros, um efeito colateral muito nocivo: a osteonecrose dos maxilares (ONM), que consiste em uma lesão rara, mas grave, da mandíbula ou maxila caracterizada por necrose óssea exposta. O denosumab é uma droga antirreabsortiva que possui um mecanismo de ação diferente do encontrado nos bisfosfonatos (BFs), medicação amplamente usada e anterior ao denosumab, entretanto já mostra efeitos colaterais similares aos BFs em relação à ONM e para ambos os medicamentos a fisiopatogenia da doença ainda não está esclarecida pela literatura Este trabalho teve como objetivo avaliar o efeito de diferentes concentrações do denosumab sobre a viabilidade, proliferação e migração de fibroblastos em cultura. Foram utilizados fibroblastos de mucosa bucal humana linhagem FMM1. Após serem submetidos aos testes de citotoxicidade com concentrações do denosumab variando de 10- 3?g a 10 - 7?g os fibroblastos não apresentaram quaisquer alterações quanto aos quesitos avaliados. Foi possível concluir que o denosumab não é citotóxico para fibroblastos em cultura. ecrose dos maxilares FibroblastosThe number of patients using drugs that target the manipulation of bone remodeling is currently increasing. Bone volume diseases such as osteoporosis and tumors have the possibility of treatment with the use of antiresorptive medications. However, these drugs, among others, may present a very harmful side effect: osteonecrosis of the jaw (ONJ), which consists of a rare but severe injury characterized by exposed bone necrosis. The denosumab is an antiresorptive drug that presents a different mechanism of action found in bisphosphonates (BPs) and shows similar side effects to BPs regarding ONJ. BPs are a class of medication widely used and prior to denosumab. In both drugs the pathophysiology of the disease it is still not clear. This study aimed to evaluate the effect of denosumab in different concentrations on the viability, proliferation and migration of fibroblasts in culture. Were used human oral mucosa fibroblasts FMM1. After being subjected to denosumab concentrations ranging from 10-3?g to 10-7?g fibroblasts did not show any changes to the variables evaluated. It was possible to concluded that denosumab is not cytotoxic to fibroblasts in culture.