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Academic literature on the topic 'Jet Nebulizer'
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Journal articles on the topic "Jet Nebulizer"
1
Chang, Moon, Oh, et al. "Comparison of Salbutamol Delivery Efficiency for Jet versus Mesh Nebulizer Using Mice." Pharmaceutics 11, no. 4 (2019): 192. http://dx.doi.org/10.3390/pharmaceutics11040192.
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Recent reports using a breathing simulator system have suggested that mesh nebulizers provide more effective medication delivery than jet nebulizers. In this study, the performances of jet and mesh nebulizers were evaluated by comparing their aerosol drug delivery efficiencies in mice. We compared four home nebulizers: two jet nebulizers (PARI BOY SX with red and blue nozzles), a static mesh nebulizer (NE-U22), and a vibrating mesh nebulizer (NE-SM1). After mice were exposed to salbutamol aerosol, the levels of salbutamol in serum and lung were estimated by ELISA. The residual volume of salbutamol was the largest at 34.6% in PARI BOY SX, while the values for NE-U22 and NE-SM1 mesh nebulizers were each less than 1%. The salbutamol delivery efficiencies of NE-U22 and NE-SM1 were higher than that of PARI BOY SX, as the total delivered amounts of lung and serum were 39.9% and 141.7% as compared to PARI BOY SX, respectively. The delivery efficiency of the mesh nebulizer was better than that of the jet nebulizer. Although the jet nebulizer can generate smaller aerosol particles than the mesh nebulizer used in this study, the output rate of the jet nebulizer is low, resulting in lower salbutamol delivery efficiency. Therefore, clinical validation of the drug delivery efficiency according to nebulizer type is necessary to avoid overdose and reduced drug wastage.
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Chang, Kyung Hwa, Sang-Hyub Moon, Sun Kook Yoo, Bong Joo Park, and Ki Chang Nam. "Aerosol Delivery of Dornase Alfa Generated by Jet and Mesh Nebulizers." Pharmaceutics 12, no. 8 (2020): 721. http://dx.doi.org/10.3390/pharmaceutics12080721.
Full textAbstract:
Recent reports on mesh nebulizers suggest the possibility of stable nebulization of various therapeutic protein drugs. In this study, the in vitro performance and drug stability of jet and mesh nebulizers were examined for dornase alfa and compared with respect to their lung delivery efficiency in BALB/c mice. We compared four nebulizers: two jet nebulizers (PARI BOY SX with red and blue nozzles), a static mesh nebulizer (NE-U150), and a vibrating mesh nebulizer (NE-SM1). The enzymatic activity of dornase alfa was assessed using a kinetic fluorometric DNase activity assay. Both jet nebulizers had large residual volumes between 24% and 27%, while the volume of the NE-SM1 nebulizer was less than 2%. Evaluation of dornase alfa aerosols produced by the four nebulizers showed no overall loss of enzymatic activity or protein content and no increase in aggregation or degradation. The amount of dornase alfa delivered to the lungs was highest for the PARI BOY SX-red jet nebulizer. This result confirmed that aerosol droplet size is an important factor in determining the efficiency of dornase alfa delivery to the lungs. Further clinical studies and analysis are required before any conclusions can be drawn regarding the clinical safety and efficacy of these nebulizers.
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Murayama, Norihide, and Kikuno Murayama. "Comparison of the Clinical Efficacy of Salbutamol with Jet and Mesh Nebulizers in Asthmatic Children." Pulmonary Medicine 2018 (2018): 1–6. http://dx.doi.org/10.1155/2018/1648652.
Full textAbstract:
Background. Ultrasonic, jet, and mesh nebulizers have all been used in the treatment for asthma. Mesh nebulizers reportedly offer the best inhalation efficiency. Methods. This study aimed to clarify the utility of the mesh nebulizer, compared to jet nebulizers, in the treatment of pediatric asthma patients. Participants included 88 children <6 years old who were receiving treatment for asthma at Murayama Pediatric Clinic. Heart rate, peripheral oxygen saturation in arterial blood, and Mitsui symptom scores were compared before and after treatment with a mesh nebulizer (n=43) or jet nebulizer (n=45) using a salbutamol inhalation solution (0.2 ml for children ≧ 2 years old, n=51; 0.1 ml for children < 2 years old, n=37). Results. Other than required inhalation time, clinical findings did not differ between mesh and jet groups. In both groups, heart rate increased significantly in patients treated with 0.2 ml (1000 microg) of salbutamol. Conclusions and Clinical Relevance. The required inhalation time of the mesh nebulizer was superior to the jet nebulizer. Children ≧ 2 years with mild asthma attacks experienced a significantly increased heart rate in both groups. The dose of salbutamol (0.2 ml for ≧2 years) used for asthma attacks should be reconsidered in mild asthma.
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Ho, Sharon L., and Allan L. Coates. "Effect of Dead Volume on the Efficiency and the Cost to Deliver Medications in Cystic Fibrosis with Four Disposable Nebulizers." Canadian Respiratory Journal 6, no. 3 (1999): 253–60. http://dx.doi.org/10.1155/1999/236068.
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OBJECTIVES: To evaluate the factors that affect nebulizer efficiency and to compare the relative cost effectiveness of nebulized medications used in the treatment of cystic fibrosis (CF), delivered by four types of disposable jet nebulizers that are widely used in hospitals.DESIGN: The Hudson 1730 Updraft II, Baxter Misty-Neb, Marquest Whisper Jet (WJ), and Marquest Acorn II were evaluated in terms of respirable aerosol output (particles 5 µm or less), nebulizer dead (residual) volume (VD), and time for complete nebulization using saline, salbutamol and tobramycin at flows of 6 and 8 L/min. The respirable fraction (RF) was determined by laser diffraction, and drug output was calculated from the initial volume and concentration of the drug in the nebulizer minus the product of final drug concentration and the VDfollowing nebulization.COST ANALYSIS: The expected pulmonary deposition (DE) was estimated, and incorporated with the material and labour costs to determine the cost effectiveness of each type of nebulizer.RESULTS: With a DEgreater than two times that of the WJ at a cost of 2.4 times less, the Updraft II proved most efficient and cost effective of all the nebulizers evaluated in this study.CONCLUSIONS: The cost effectiveness of each nebulizer was determined by its efficiency, which in turn was predominantly related to its VDand RF at each flow. The efficiencies of these four devices were different and could not have been predicted from specifications provided by the respective manufacturers.
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Misik, Ondrej, Milan Maly, Ondrej Cejpek, and Frantisek Lizal. "Characterization of Aerosol Nebulized by Aerogen Solo Mesh Nebulizer." MATEC Web of Conferences 328 (2020): 01006. http://dx.doi.org/10.1051/matecconf/202032801006.
Full textAbstract:
Nebulizers are commonly used devices for inhalation treatment of various disorders. There are three main categories of medical nebulization technology: jet nebulizers, ultrasound nebulizer, and mesh nebulizer. The mesh nebulizers seem to be very promising since this technology should be able to produce aerosol with precisely determined particle size and is easy to use as well [1]. Aerosol generated from the mesh nebulizer Aerogen Solo was measured in this work. Particle size distribution with a mass median of aerodynamic diameter (MMAD) was determined by two different methods.
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Santosa, Agus, and Endiyono Endiyono. "Respiration Status of Asthma Patients Who Get Nebulisation Using Jet Nebulizer Compared to Nebulizer Using Oxygen." Jurnal Respirologi Indonesia 38, no. 4 (2019): 187–91. http://dx.doi.org/10.36497/jri.v38i4.19.
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Background: Some of regional hospitals still provide oxygen gas for nebulizer to therapies in astma patiens. The study was aimed to observe the effectiveness of jet nebulizer vs oxygen as a driving gas for nebulizer on respiratory parameters of asthma patients which is breath pattern, respiration rate (RR), breath sound, oxygen saturation (SpO2), peak expiratory flow rate (PEF}.
 Method: The research was an experimental with a combination design, pre-post test with control group and post test only with control group in RSUD dr. R. Goeteng Taroenadibrata Purbalingga consisted of 60 respondents selected by proportional stratified random sampling. Data analysis used was independent t-test and fisher’r exact test.
 Result: There was no difference in the respiratory pattern variables between jet nebulizer and oxygen as a driving gas nebulizers (p> 0.05). The jet nebulizer was better in reducing RR in asthma patients than the oxygen as a driving gas nebulizer (p
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Menon, Mala, Isha Naik, Gopal Singh Rajawat, Mangal Nagarsenker, and Korukonda Krishnaprasad. "NEBULIZED GLYCOPYRRONIUM AND FORMOTEROL, BUDESONIDE AEROSOL AERODYNAMIC ASSESSMENT WITH VIBRATING MESH AND COMPRESSOR AIR NEBULIZER: ANDERSON CASCADE IMPACTOR STUDY." Journal of Drug Delivery and Therapeutics 9, no. 6 (2019): 79–82. http://dx.doi.org/10.22270/jddt.v9i6.3465.
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Vibrating mesh nebulizers (VMN) demonstrate improved efficiency for delivery of inhaled aerosol solutions or suspensions as compared to compressor devices. The added advantages of compactness, portability and functioning as noise-free device makes them of incremental value in Home or Ambulatory settings while managing Severe Obstructive airway disease or delivery of maintenance medications in these cases. This further circumvents the need for multiple devices thereby further improving patient compliance and convenience while delivering acute or maintenance formulations including Glycopyrronium (GLY) and Formoterol (FRM)/Budesonide(BUD) nebulizing solution formulations. To further assess the clinical role and feasibility of FRM-BUD formulation delivery kinetics with or without GLY nebulizing solution through VMN and jet nebulizers for In- & outpatient settings, 2 comparative in-vitro lung deposition studies were carried out utilizing Anderson Cascade impactor at 30 L/min; deposited drug concentrations in different stages were suitably collected and estimated by HPLC. Post-hoc analyses with p<0.05 was considered statistically significant for intergroup differences on FRM/BUD and GLY delivered through VMN or Compressor devices. The calculated mean fine particle dose for FRM & BUD delivered by VMN or jet nebulizer showed no statistical difference. However the mean fine particle fraction for BUD delivered by VMN was significantly better compared to jet nebulizer than that for FRM. The Residual volume at 10 mins was significantly higher with jet nebulizer. The optimal APSD for GLY nebulizing solution admixture with FRM/BUD suspension delivered through VMN and Jet nebulizer offers a clinically relevant strategy for High risk COPD cases in Acute or Home settings.
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Zaytsev, A. A., M. A. Kharitonov, V. A. Chernetsov, and E. V. Kryukov. "Current possibilities for nebulizer therapy." Medical Council, no. 15 (December 8, 2019): 106–11. http://dx.doi.org/10.21518/2079-701x-2019-15-106-111.
Full textAbstract:
This article discusses the main aspects of the nebulizer therapy used to treat respiratory diseases. The basic principle of operation of all types of nebulizers is based on the generation of aerosol containing particles comprising an active substance. Currently, there are three types of nebulizers: jet, or compressor (which uses the energy of a gas jet), ultrasonic (which uses oscillation energy of the piezoelectric element) and membrane (Mesh nebulizers). The jet nebulizers are the most common, because they have affordable cost, are easy to use, however, using this type of nebulizers is accompanied by quite large losses of the drug (more than 50%), and they are quite noisy due to the compressor. Among the advantages of ultrasonic nebulizers are virtually silent operation, fast aerosol production and shorter inhalation times compared to compressor devices, small size and weight, and operation from the batteries. However, one of the most important disadvantages of ultrasonic nebulizers is the limited range of drugs that can be used for inhalation, which significantly limits their use in pulmonological practice. In particular, they are not suitable for inhalation of suspensions (glucocorticosteroids) due to the impossibility of homogeneous nebulization, in addition, part of the GCS molecules are destroyed by ultrasound. In recent years, the greatest prospects have been associated with the use of a new generation of nebulizers created using the so-called Vibrating Mesh Technology. Membrane nebulizers have a number of advantages compared to the compressor and ultrasonic devices. Among them are a small residual volume, noiseless operation, high mobility due to the small size, weight and ability to operate using battery.
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Belotserkovskaya, Yu G. "Рossibilities of clinical application of modern nebulizers". Meditsinskiy sovet = Medical Council, № 17 (22 листопада 2020): 50–55. http://dx.doi.org/10.21518/2079-701x-2020-17-50-55.
Full textAbstract:
The simplicity of converting medicinal solutions and suspensions into aerosols using mechanical and thermal energy, convenient delivery to the airways allows nebulizers to take a worthy place in the treatment of hospitalized and outpatient patients. Different types of nebulizers are available for use in the home and in medical settings (jet, ultrasound, membrane), and researches show that the performance and characteristics of the aerosol vary between different devices and manufacturers. Jet nebulizers are still the most used devices that do not require coordination of inhale and delivery of aerosol to the respiratory tract. To reduce the consumption of medicinal aerosol and optimize the air flow, virtual valve technology (V.V.T.) is being improved, and breath-actuated nebulizers are being created. The advantage of nebulizer therapy is the ability to apply large doses of medications, use substances that exist only in inhaled form. The choice falls on the nebulizer in cases where the patient can not use other delivery devices, for example, if the patient is unable to coordinate the inhalation and intake of the drug into the respiratory tract, with a severe exacerbation of obstructive disease, in the presence of motor disorders. The optimal delivery device for children of any age, including newborns, is a nebulizer. The most common indication for nebulizer therapy is the delivery of bronchodilators and inhaled corticosteroids for asthma or chronic obstructive pulmonary disease, as well as the treatment of upper respiratory tract diseases, in particular croup in children. An important place is given to nebulizers when it is necessary to prescribe certain mucolytics and antibiotics. In the treatment of emergency conditions, inhalation administration of drugs may be required, including situations when the patient is on mechanical ventilation or has a tracheostomy installed. The significance of nebulizers in the treatment of cystic fibrosis, pulmonary arterial hypertension, and alpha-1-antitrypsin deficiency is being studied. The possibilities of endobronchial delivery of heparin, insulin, and monoclonal antibodies are evaluated.
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Hofstetter, E., H. Ehlich, B. Muellinger, and G. Scheuch. "Lung deposition of aerosolized anticancer drugs with a novel inhalation system: AKITA." Journal of Clinical Oncology 24, no. 18_suppl (2006): 12037. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.12037.
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12037 Background: Inhalation of anticancer drugs might be a helpful route of delivery in cancer therapy, particularly for lung tumors and metastasis in the lungs. In this experimental setup 12 different drugs (including antineoplastic drugs and immunotherapeutics) were nebulized with two different jet nebulizer systems. Aerosol particle size (MMD) and mass output were characterized. Methods: MMD was measured using a laser diffraction system (Sympatec, Clausthal-Zellerfeld, Germany). Mass output measurements were performed after CEN Standard using a Flow/volume simulator with radiolabelled (99m Tc) solution/suspension. The amount of radioactivity on the filters was detected with a scintillation counter. For aerosolization two nebulizer systems were used: Pari LC Plus with Pari compressor (PARI) and Pari LC Star with AKITA compressor (AKITA). To determine lung deposition a lung deposition model (International Commission of Radiological Protection, ICRP66, 1994) was used, taking into account: mass output, particle size and breathing pattern of patients. The AKITA guides the patient with a positive pressure through the inhalation maneuver, it is breath activated and delivers the medication only during inspiration. The PARI nebulizes continuously and the patient inhales with different individual breathing pattern. Results: MMD with PARI was found to be 4.2 ± 0.4 μm compared to 3.40 ± 0.3 μm for AKITA. After filling 2.5 ml into the nebulizers we found 1.4 ml residual volume with PARI and 1.0 ml for AKITA. The output rate was 0.15 ± 0.02 ml/min for PARI and 0.29 ± 0.03 ml/min for AKITA. Lung deposition relative to the emitted dose was determined to be 28 ± 10% for PARI and 85 ± 4% for AKITA. This is because the AKITA nebulizes only during inspiration and guides the patient through the inhalation maneuver, where as the PARI is running continuously and patients inhale with different breathing pattern. The result is that from 2.5 ml filled into the nebulizer, on average 0.3 ml will be deposited in the lungs with the PARI and 1.3 ml with the AKITA. To deposit 1 ml in the lungs with AKITA it will take 7 min, with PARI about 24 min. Conclusions: By use of modern inhalation devices with controlled inhalation lung deposition for cancer therapy can be optimized. [Table: see text]