Dissertations / Theses on the topic 'JHDL'
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Atwell, James W. "A Multiplexed Memory Port for Run Time Reconfigurable Applications." Thesis, Virginia Tech, 1999. http://hdl.handle.net/10919/36219.
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The difficulties of implementing run time reconfiguration (RTR) on CCMs are
addressed in this thesis. Tools and techniques are introduced to simplify the development
and synthesis of applications and partitions for RTR applications. A multiplexed memory
port (MMP) is presented in JHDL and VHDL that simplifies the memory interface, eases
the task of writing applications and creating partitions, and makes applications platform
independent. The MMP is incorporated into an existing CCM compiler. It is shown that
the MMP can increase the compiler's functionality and efficiency.
Master of Science
Poetter, Alexandra Vanessa. "JHDLBits: An Open-Source Model for FPGA Design Automation." Thesis, Virginia Tech, 2004. http://hdl.handle.net/10919/10121.
Full textMaster of Science
Hunter, Jesse Everett III. "A Device-Level FPGA Simulator." Thesis, Virginia Tech, 2000. http://hdl.handle.net/10919/10041.
Full textMaster of Science
DASASATHYAN, SRINIVASAN. "SYNTHESIS OF VIRTUAL PIPELINES ON VIRTEX-BASED FPGAs." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin990618529.
Full textSlade, Anthony Lynn. "Designing, Debugging, and Deploying Configurable Computing Machine-based Applications Using Reconfigurable Computing Application Frameworks." Diss., CLICK HERE for online access, 2003. http://contentdm.lib.byu.edu/ETD/image/etd186.pdf.
Full textTu, Shengjiang. "Identification Of Histone Demthylases In Budding Yeast And DNA Binding Motifs Of Human Demethylase RBP2." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1211487400.
Full textLienhard, Demian [Verfasser], Michael [Gutachter] Heinzelmann, Dietrich [Gutachter] Boschung, and Walter [Gutachter] Ameling. "Römische fora in Italien. Funktionen und Funktionswandel öffentlicher Platzanlagen vom 3. Jhdt. v. Chr. bis ins 5. Jhdt. n. Chr. / Demian Lienhard ; Gutachter: Michael Heinzelmann, Dietrich Boschung, Walter Ameling." Köln : Universitäts- und Stadtbibliothek Köln, 2017. http://d-nb.info/1210642743/34.
Full textHerrmann, Moritz Sebastian. "Molecular and genomic studies on the histone lysine demethylase JHDM-1 in Caenorhabditis elegans." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648716.
Full textEich, Paul [Verfasser], Harald [Gutachter] Keller, and Julius [Gutachter] Schwietering. "Die Maria Lactans : eine Studie ihrer Entwicklung bis in das 13. Jhd. und ein Versuch ihrer Deutung aus der mittelalterlichen Frömmigkeit / Paul Eich ; Gutachter: Harald Keller, Julius Schwietering." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2012. http://d-nb.info/113965103X/34.
Full textLin, Chun-Liang, and 林俊良. "Synthetic Lethal Analysis of JHD1 from Saccharomyces cerevisiae." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/11325832639824269059.
Full text淡江大學
生命科學研究所碩士班
96
The synthetic lethal screen is a powerful genetic screen that relies on finding the secondary molecular targets. In principle, this screen can identify any mutant gene which causes cell death with a nonlethal “primary” mutation. The synthetic lethal screen is a method of isolating novel mutants whose survival is dependent on the gene of interest. Combining the colony-color assay, this method will offer a means to visually detect a mutant that depends on a plasmid for survival. The synthetic lethal screen must be carry out in the following four processes : (i) The gene function of interest should be disrupted in a strain containing ade2 ade3/ade8 mutations, which result in a white phenotype. (ii) Combining the wild-type gene of interest and ADE3/ADE8 in a plasmid which is then transformed into the strain of step (i). The cells will produce red-white sector, and the white colonies have lost the plasmid. (iii) A mutagenesis will be performed to introduce random mutations into the strain genome. The mutant must dependents on the gene of interest from plasmid of step (ii) for survival and produce red solid colonies. (iv) The synthetic lethal(SL) colonies are transformed with a library. Then the mutants containing complementing DNA are no longer dependent on the gene of interest, and the cells with red-white sectoring are identified. Finally,the synthetic lethal gene can be sequencd from the complement plasmid.
Wan-Hua and 許婉華. "Dissecting the role of Candida albicans histone H3 lysine 4 demethylase Jhd2." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/63983147051083547504.
Full text中山醫學大學
生物醫學科學學系碩士班
100
Candida albicans is an opportunistic human fungal pathogen. Invading and damaging host tissues when the equilibrium of individual environment is disturbed. Nosocomial infection prolong the discharge time of patients, which increase personal and economic cost. The harmful side effect to human cell and resistance to antifungal drugs have made continuous development of new antifungal drugs necessary. Recent progress in developing small molecules to fungal cellular targets suggests that comprehensive understanding the molecular mechanism underlying Candida albicans virulence is essential to continunous exploration of drugs specific to cellular targets of Candida albicans. The transition of C. albicans among diverse morphological states and ability to form biofilm are the key determinants of its ability to cause systemic candidiasis and resistance to antifungal drugs. The biofilm structure prevents cells from being washed away and support the spread of cells. C. albicans exploits their capacity to adhere to many surfaces. However, it is remain incompletely understood as to how the environment cues are intertwined with genetic factors determines the alteration of adhesion properties. Our previous study reveals that CaCdc4, functioning through the E3 ubiquitin ligase, participates in the repression in filamentous growth of C. albicans. We have identified CaORF19.5651(CaJHD2) as one of the CaCdc4 associated proteins by affinity purification. Jhd2 is histone H3 lysine 4 (H3K4) demethylase in Saccharomyces cerevisiae and other species. CaJhd2 possesses a highly conserved JmjC domain-containg demetylase 2 that is known to require for demethylation of H3K4. It is known that the H3K4 methylation contribute to the capacity of adhesion and morphogenesis in C. albicans. As a result, I aim to investigate the H3K4 demethylase activity of CaJhd2 and the functional consequence of CaJHD2 deficiency. The demethylase of H3K4 of C. albicans has not been verified to date, and the H3K4 methylated modification remains poorly known. To investigate whether the CaJhd2 is a demethylase specifically for H3K4, I constructed a homozygous jhd2 null mutant jhd2Δ/Δ using wild-type strain SC5314 and have examined the mono-, di-, and trimethylation levels of H3K4 of the mutant in comparison with those of the wild-type strain. I confirmed that the CaJhd2 is a H3K4 mono-demethylase of C. albicans but the di-, tri- demethylase activity specifically for H3K4 remains undetermined. In addition, I observed increase of cellular flocculation of jhd2Δ/Δ in relation in spider medium that contains mannitol and phosphate. This suggests that the deficiency of CaJHD2 may be involved in adhesion of cell-to-cell and cell to nonbiotic materials, although its effect to the ability of biofilm formation in C. albicans remains inconclusive.
Lin, Yi-Pei, and 林沂霈. "Assessment of Candida albicans H3K4 Demethylase-encoding Gene JHD2 on Virulence-related Characteristics." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/bzszrb.
Full text中山醫學大學
生物醫學科學學系碩士班
102
Candida albicans is an opportunistic human fungal pathogen. It’s morphological plasticity amonst yeast, hyphae and true hyphae is known to associate with virulence. While yeast cells can distribute the whole body of host via blood stream, hyphal cell are important to invade tissues the host cause damage. Biofilm constituted with various cell types could increase virulence and drug resistance. Our previous study have shown that CaCDC4, encoding an E3 ubiquitin ligase, participates in the repression in filamentous growth of C. albicans. During search for interactors of CaCdc4, we found a protein encoding by JHD2 (C. albicans orf19.5651), but C. albicans Jhd2 protein (CaJhd2p) was later excluded to be directly interacted with CaCdc4. C. albicans JHD2 (CaJHD2) encodes a histone 3 lysine 4 (H3K4) demethylase found in many species but is unknown in Candida albicans. Previous reports have shown that at least two genes involved in regulation of H3K4 in C. albicans exhibit morphological alteration that is associated with virulence. Hence, wehave sought to determine if CaJhd2p acts as a H3K4 demethylase for virulence-associated phenotypes in Candida albicans. We made Cajhd2 homozygous null mutant and assessed in comparison with the wild-type strain the consequence of growth, colony morphology, ability in aggregation, flocculation, biofilm formation, and antifungal resistance. We found that cells lacking CaJHD2 were unaffected on growth. However, cells lacking CaJHD2 appeared to be different on colony morphology. In the hypha-inducing Spider medium, cells of the Cajhd2 homozygous null mutant exhibited greater ability to aggregate but did not similar extent in flocculation. In addition, cells lacking CaJHD2 increase their ability to biofilm assayed on the biocompatible silicon. Cells deficient in CaJHD2 appeared to be unaltered on antifungal drug brefeldin A (BFA) resistance. Antibodies specific to mono-, di-, tri-methylation of H3K4 revealed that cells lacking CaJHD2 accumulate tri-methyl on H3K4. We suggest that CaJHD2 may act as a H3K4 tri-demethylase, through which alters the expression of a set of C. albicans genes involved in adhesion of cells, morphological transition, and biofilm formation upon stimulation by filament-inducing agents.
Sayer, Liane. "Die Donauschwaben im Batscherland anhand der Chronik der Familie Sayer : Schwerpunkt 20. Jhd. /." 1990. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=017169807&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Full textChau-cien, Hong, and 洪肇謙. "Evaluation of Earthquake Location Uncertainty in Taiwan : Earthquake Relocation with Explosions by JHD." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/62441243646369808053.
Full text國立中央大學
地球科學學系
103
The young Taiwan orogen is situated on the plate boundary between the Eurasian and Philippine sea plates. Owing to the high convergent rate between these two plates, the crustal structure in Taiwan is complicated and three-dimensional. As a consequence, earthquake locations routinely determined by 1D velocity structure from Central Weather Bureau (CWB) is not sufficient for the seismogenic studies. Although several 3D velocity structures have been published and were used for the earthquake relocations, it is great to provide other methods to estimate the uncertainty of the earthquake locations from the routine. In 2008, the TAIGER project has conducted an active source experiment, which provides 10 explosions as known source locations to calibrate the earthquake locations from 1D model. In this study, we use Joint Hypocentral Determination (JHD) with explosions as master events to relocate earthquakes between Jan. 2001 and Sep. 2013 from CWB catalogue to estimate the uncertainties. As a result, the earthquake location by 1D model is highly influenced by the 3D crustal structure, which was revealed by the station corrections from JHD. The station corrections in the mountains can be up to -2.3 sec and those in the plain area are around 2.2 sec and the magnitudes of station corrections are slightly different between the northern and southern Taiwan. The horizontal and vertical shifts of earthquake locations are around 1.0~4.9 km and -1.8~0.9 km, respectively. One of the largest shifts among those shot regions is in northwestern Taiwan (N2 shot) with 4.9±1.4 km in horizontal and -1.2±1.4 km in vertical and the shift direction is 306±16.1°. On the other hand, the region with the smallest shift is in southwestern Taiwan (S2 shot) with with 1.0±0.8 km in horizontal and 0.9±1.4 km in vertical and the shift direction is 176±54.5°.
(5930213), Faeze Saatchi. "INVESTIGATING ROLES OF THE METABOLIC ENZYME FUMARASE AND THE METABOLITE FUMARATE IN DNA DAMAGE RESPONSE." Thesis, 2019.
Find full textIn eukaryotic cells, DNA
is packaged into a structure named chromatin which contains DNA and proteins.
Nucleosomes are building blocks of chromatin and contain DNA wrapped around a
histone octamer. Chromatin modifications (histone post-translational modifications
and histone variants) play central roles in various cellular processes
including gene expression and DNA damage response. Chromatin modifying enzymes
use metabolites as co-substrates and co-factors, and changes in metabolic pathways
and metabolite availability affects chromatin modifications and
chromatin-associated functions. Moreover, recent studies have uncovered direct
roles of metabolic enzymes in chromatin-associated functions. Fumarase, a TCA
cycle enzyme that catalyzes the reversible conversion of fumarate to malate in
mitochondria (a hydration reaction), is an example of an enzyme with dual
functions in metabolism and genome integrity. Cytoplasmic fraction of yeast fumarase,
Fum1p, localizes to the nucleus and promotes growth upon DNA damage. Fum1p promotes
homologous recombination by enhancing DNA end resection. Human fumarase is
involved in DNA repair by non-homologous end joining. Here, we provide evidence
that yeast Fum1p and the histone variant Htz1p are also involved in DNA
replication stress response and DNA repair by non-homologous end joining (NHEJ).
Using mutants lacking the histone variant HTZ1, we show that high
cellular levels of fumarate, by deletion of FUM1 or addition of
exogenous fumarate, suppressed the sensitivity to DNA replication stress by
modulation of activity of Jhd2p. This suppression required sensors and
mediators of the intra-S phase checkpoint, but not factors involved in the
processing of replication intermediates. These results imply that high cellular
levels of fumarate can confer resistance to DNA replication stress by bypassing
or complementing the defects caused by loss of HTZ1 and replication fork
processing factors. We also show that upon induction of DSBs, exogenous
fumarate conferred resistance to mutants with defects in NHEJ, early steps of
homologous recombination (DNA end resection pathway) or late steps of
homologous recombination (strand invasion and exchange). Taken together, these
results link the metabolic enzyme fumarase and the metabolite fumarate to DNA
damage response and show that modulation of DNA damage response by regulating
activity of chromatin modifying enzymes is a plausible pathway linking
metabolism and nutrient availability to chromatin-associated functions like
genome integrity.
HUANG, WEN-PIN, and 黃文彬. "To explore the impact of the player's sports motivation climate of the team in I Junior High School Basketball League (JHBL) of Team on the team cohesion." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/2zde5q.
Full text國立屏東大學
體育學系碩士班
107
The purpose of this study is to explore the impact of the player's perceptual sports motivation climate in I junior high basketball league (JHBL) on team cohesion. Participants were a total of 184 players (male: 93; women's 91) in 8 schools in both male and female national basketball teams, with an average age of 14.35 ± 0.68 years. With the consent of the participants, the collection of data including the Perceived Motivational Climate in Sport Questionnaire (PMCSQ) and the Group Environment Questionnaire was completed. Descriptive statistics, independent sample t test, pearson product moment coefficient of correlation , and multivariate hierarchical regression statistical methods were used to analyze the data. The results of the study found that exercise-motivated climate can effectively explain work cohesion); similar contributions to social cohesion. According to the results of the research, it is shown that the climate of sports motivation is one of the important factors influencing team cohesion. Therefore, when improving team effectiveness, coaches not only need to demonstrate a reasonable leadership model, but also should focus on the motivation climate for shaping work orientation and reduce the motivational climate for self-orientation.
Anders, Stefanie. "Schloss Söder 1742-1796. Baugeschichtliche Studien zu einem repräsentativen Landsitz der Familie von Brabeck im Fürstbistum Hildesheim." Doctoral thesis, 2012. https://repositorium.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-2012021710045.
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