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Journal articles on the topic 'JHDL'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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1

Fang, Jia, Gregory J. Hogan, Gaoyang Liang, Jason D. Lieb, and Yi Zhang. "The Saccharomyces cerevisiae Histone Demethylase Jhd1 Fine-Tunes the Distribution of H3K36me2." Molecular and Cellular Biology 27, no. 13 (April 30, 2007): 5055–65. http://dx.doi.org/10.1128/mcb.00127-07.

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ABSTRACT Histone methylation plays important roles in the regulation of chromatin dynamics and transcription. Steady-state levels of histone lysine methylation are regulated by a balance between enzymes that catalyze either the addition or removal of methyl groups. Using an activity-based biochemical approach, we recently uncovered the JmjC domain as an evolutionarily conserved signature motif for histone demethylases. Furthermore, we demonstrated that Jhd1, a JmjC domain-containing protein in Saccharomyces cerevisiae, is an H3K36-specific demethylase. Here we report further characterization of Jhd1. Similar to its mammalian homolog, Jhd1-catalyzed histone demethylation requires iron and α-ketoglutarate as cofactors. Mutation and deletion studies indicate that the JmjC domain and adjacent sequences are critical for Jhd1 enzymatic activity, while the N-terminal PHD domain is dispensable. Overexpression of JHD1 results in a global reduction of H3K36 methylation in vivo. Finally, chromatin immunoprecipitation-coupled microarray studies reveal subtle changes in the distribution of H3K36me2 upon overexpression or deletion of JHD1. Our studies establish Jhd1 as a histone demethylase in budding yeast and suggest that Jhd1 functions to maintain the fidelity of histone methylation patterns along transcription units.

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Antoniou, Alexandros‐Stamatios G., Marilyn J. Davidson, and Cary L. Cooper. "Occupational stress, job satisfaction and health state in male and female junior hospital doctors in Greece." Journal of Managerial Psychology 18, no. 6 (September 1, 2003): 592–621. http://dx.doi.org/10.1108/02683940310494403.

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This study investigates the occupational stress amongst 355 male and female Greek junior hospital doctors (JHDs) working in the Greater Athens area. The initial phase of the research involved in‐depth interviews with a random stratified sample of sixty JHDs, both male and female, in a variety of specialties of junior hospital staff. An extended version of the occupational stress indicator (OSI) questionnaire was developed, incorporating additional items based on the results of the qualitative part of the study, and on previous research findings in the same area. The sample consisted of 193 males and 162 females JHDs, who completed the OSI. Analyses of the data demonstrated that, overall, JHDs presented significantly higher levels of sources of pressure than the normative population and other comparative occupational samples. As regards the various sub‐group comparisons, bivariate analyses revealed that there were significant differences between male and female JHDs in certain aspects of pressure (“career and achievement” and “home/work interface”). Multivariate analyses revealed that predictors of physical and mental ill health and job dissatisfaction were type A behaviour and “demands of the profession” respectively. The research implications of the findings are discussed.

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3

Douglas, Masako O., Hiroko C. Kataoka, and Kiyomi Chinen. "The Development of Japanese as a Heritage Language in the Los Angeles Conurbation." Heritage Language Journal 10, no. 3 (December 30, 2013): 336–56. http://dx.doi.org/10.46538/hlj.10.3.6.

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This paper examines the current status of Japanese as a heritage language (JHL) in the Los Angeles conurbation, applying the Capacity-Opportunity-Desire (COD) framework. After briefly describing the Japanese-American community and the history of JHL education in the United States with a focus on the Los Angeles conurbation, we review research to date on JHL capacity development in JHL schools and the role of the family in JHL development. We then present the results of two studies and analyze factors that contribute to JHL development,reflecting on COD principles. We conclude by presenting suggestions for future research on JHL based on this framework.

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4

Jurkić, Tomislav, and Dubravka Kotnik-Karuza. "Modeling of Circumstellar Dust by the DUSTY Code." Proceedings of the International Astronomical Union 7, S282 (July 2011): 247–50. http://dx.doi.org/10.1017/s1743921311027451.

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AbstractWe present a circumstellar dust model around the symbiotic Mira RR Tel obtained by modeling the near-infrared JHKL magnitudes and ISO spectra. In order to follow the evolution of infrared colours in time, the published JHKL magnitudes were corrected by removing the Mira pulsations. The RR Tel light curves show three obscuration events in the near-IR. Using the simultaneously available JHKL magnitudes and ISO spectra in three different epochs, we obtained SEDs in the near- and mid-IR spectral region (1-20 μm) in epochs with and without obscuration.The DUSTY numerical code was used to solve the radiative transfer and to determine the circumstellar dust properties of the inner dust regions around the Mira, assuming a spherical dust temperature distribution in its close neighbourhood. The physical properties of the dust, mass loss and optical depth during intervals with and without obscuration have been obtained. Both JHKL and ISO observations during the obscuration period can be reproduced with a spherical dust envelope, while ISO spectra outside obscuration show a different behaviour. The dynamical behaviour of the circumstellar dust was obtained by modeling the JHKL magnitudes observed during the span of more than 30 years.The DUSTY code was also successfully applied in the modeling of circumstellar dust envelopes of young stellar objects, such as Herbig Ae/Be stars.

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5

Tereshchenko, Alexander, Vincent Magnotta, Eric Epping, Katherine Mathews, Patricia Espe-Pfeifer, Erin Martin, Jeffrey Dawson, Wenzhen Duan, and Peg Nopoulos. "Brain structure in juvenile-onset Huntington disease." Neurology 92, no. 17 (April 10, 2019): e1939-e1947. http://dx.doi.org/10.1212/wnl.0000000000007355.

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ObjectiveTo assess brain morphometry in a sample of patients with juvenile-onset Huntington disease (JOHD) and several mouse models of Huntington disease (HD) that likely represent the human JOHD phenotype.MethodsDespite sharing the mutation in the Huntingtin gene, adult-onset HD characteristically presents as a hyperkinetic motor disorder, while JOHD typically presents as a hypokinetic motor disease. The University of Iowa Kids-JHD program enrolls individuals 5 to 25 years of age who have already received the clinical diagnosis. A total of 19 children with juvenile HD (JHD) (mean CAG = 72) were studied. Patients with JHD were compared to healthy controls (n = 234) using a cross-sectional study design. Volumetric data from structural MRI was compared between groups. In addition, we used the same procedure to evaluate brain morphology of R6/2, zQ175, HdhQ250 HD mice models.ResultsParticipants with JHD had substantially reduced intracranial volumes. After controlling for the small intracranial volume size, the volumes of subcortical regions (caudate, putamen, globus pallidus, and thalamus) and of cortical white matter were significantly decreased in patients with JHD. However, the cerebellum was proportionately enlarged in the JHD sample. The cerebral cortex was largely unaffected. Likewise, HD mice had a lower volume of striatum and a higher volume of cerebellum, mirroring the human MRI results.ConclusionsThe primary pathology of JOHD extends beyond changes in the striatal volume. Brain morphology in both mice and human patients with JHD shows proportional cerebellar enlargement. This pattern of brain changes may explain the unique picture of hypokinetic motor symptoms in JHD, which is not seen in the hyperkinetic chorea-like phenotype of adult-onset HD.

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6

Gatto, Emilia Mabel, Virginia Parisi, José Luis Etcheverry, Ana Sanguinetti, Lorena Cordi, Adrian Binelli, Gabriel Persi, and Ferdinando Squitieri. "Juvenile Huntington disease in Argentina." Arquivos de Neuro-Psiquiatria 74, no. 1 (November 24, 2015): 50–54. http://dx.doi.org/10.1590/0004-282x20150192.

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ABSTRACT We analyzed demographic, clinical and genetic characteristics of juvenile Huntington disease (JHD) and it frequency in an Argentinean cohort. Age at onset was defined as the age at which behavioral, cognitive, psychiatric or motor abnormalities suggestive of JHD were first reported. Clinical and genetic data were similar to other international series, however, in this context we identified the highest JHD frequency reported so far (19.72%; 14/71). Age at onset of JHD is challenging and still under discussion. Our findings reinforce the hypothesis that clinical manifestations, other than the typical movement disorder, may anticipate age at onset of even many years. Analyses of JHD cohorts are required to explore it frequency in populations with different backgrounds to avoid an underestimation of this rare phenotype. Moreover, data from selected populations may open new pathways in therapeutic approaches and may explain new potential correlations between HD presentations and environmental or biological factors.

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7

Blair, Lauren P., Zongzhi Liu, Ramon Lorenzo D. Labitigan, Lizhen Wu, Dinghai Zheng, Zheng Xia, Erica L. Pearson, et al. "KDM5 lysine demethylases are involved in maintenance of 3′UTR length." Science Advances 2, no. 11 (November 2016): e1501662. http://dx.doi.org/10.1126/sciadv.1501662.

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The complexity by which cells regulate gene and protein expression is multifaceted and intricate. Regulation of 3′ untranslated region (UTR) processing of mRNA has been shown to play a critical role in development and disease. However, the process by which cells select alternative mRNA forms is not well understood. We discovered that theSaccharomyces cerevisiaelysine demethylase, Jhd2 (also known as KDM5), recruits 3′UTR processing machinery and promotes alteration of 3′UTR length for some genes in a demethylase-dependent manner. Interaction of Jhd2 with both chromatin and RNA suggests that Jhd2 affects selection of polyadenylation sites through a transcription-coupled mechanism. Furthermore, its mammalian homolog KDM5B (also known as JARID1B or PLU1), but not KDM5A (also known as JARID1A or RBP2), promotes shortening ofCCND1transcript in breast cancer cells. Consistent with these results, KDM5B expression correlates with shortenedCCND1in human breast tumor tissues. In contrast, both KDM5A and KDM5B are involved in the lengthening ofDICER1. Our findings suggest both a novel role for this family of demethylases and a novel targetable mechanism for 3′UTR processing.

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8

Xi, Song-yang, Yu-hao Teng, Yan Chen, Jie-ping Li, Ying-ying Zhang, Shen-lin Liu, Xi Zou, Jin-yong Zhou, Jian Wu, and Rui-ping Wang. "Jianpi Huayu Decoction Inhibits Proliferation in Human Colorectal Cancer Cells (SW480) by Inducing G0/G1-Phase Cell Cycle Arrest and Apoptosis." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/236506.

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Jianpi Huayu Decoction (JHD), a Chinese medicine formula, is a typical prescription against multiple tumors in the clinical treatment, which can raise quality of life and decrease complications. The aim of this study is to assess the efficacy of JHD against human colorectal carcinoma cells (SW480) and explore its mechanism. MTT assay showed that JHD decreased the cellular viability of SW480 cells in dose-dependent and time-dependent manner. Flow cytometry analysis revealed that JHD induced G0/G1-phase cell cycle arrest in SW480 cells and had a strong apoptosis-inducing effect on SW480 cells. Meanwhile it enhanced the expression of p27, cleaved PARP, cleaved caspase-3, and Bax and decreased the levels of PARP, caspase-3, Bcl-2, CDK2, CDK4, CDK6, cyclin D1, cyclin D2, cyclin D3, and cyclin E1, which was evidenced by RT-qPCR and Western blot analysis. In conclusion, these results indicated that JHD inhibited proliferation in SW480 cells by inducing G0/G1-phase cell cycle arrest and apoptosis, providing a practicaltherapeutic strategy against colorectal cancer.

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9

Feki, Fatma, Chahnez Triki, and Nesrine Amara. "Drug-Resistant Myoclonic Epilepsy Revealing Juvenile Huntington's Disease: A Case Report." Journal of Pediatric Epilepsy 07, no. 01 (March 2018): 021–23. http://dx.doi.org/10.1055/s-0038-1641727.

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AbstractJuvenile Huntington's disease (JHD) shares many general clinical features with the adult form. One important difference is that JHD patients experience more epileptic manifestations, sometimes difficult to control. We describe an atypical clinical picture of a genetically confirmed JHD patient diagnosed during evaluation for a progressive myoclonic epilepsy. A female patient with a family history of psychiatric disorders developed recurrent drug-resistant myoclonic seizures at the age of 6 years, followed by extrapyramidal symptoms (rigidity and dystonia). Cognitive impairment, akinetic rigidity syndrome, and dystonia were noticed at the age of 10 years. Epileptiform abnormalities were noted in ictal electroencephalography. Magnetic resonance imaging showed brain atrophy. Genetic testing for HD confirmed the diagnosis. JHD can initially manifest as myoclonic epilepsy. A DNA testing should be performed if clinical history is suggestive.

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10

Pujol, Jose. "An integrated 3D velocity inversion—joint hypocentral determination relocation analysis of events in the Northridge area." Bulletin of the Seismological Society of America 86, no. 1B (February 1, 1996): S138—S155. http://dx.doi.org/10.1785/bssa08601bs138.

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Abstract A subset of 3371 events recorded in the Northridge area by the Southern California Seismic Network during January to April 1994 was relocated with the joint hypocentral determination (JHD) technique. This analysis showed two unexpected results: (a) the JHD locations are shifted about 3.9 km on average in a northwest direction with respect to the locations determined using a single-event location (SEL) program, and (b) the station corrections vary between −0.55 and 1.26 sec, a rather large range. In addition, the JHD locations are less scattered than the SEL locations. For each station, the weighted average of the arrival time residuals obtained when the events are located with the SEL program (which does not apply distance or error weighting) are generally smaller than the corresponding JHD corrections. The locations determined with SEL and using the weighted average residuals as station corrections do not differ much from the SEL locations, but on average the RMS residuals become as small as those corresponding to the JHD locations. As the magnitude of the station corrections indicates the presence of large lateral velocity variations, a 3D velocity model for the area was determined using the arrival times of 1012 events recorded by at least 17 stations. The initial velocity model was that used routinely by the Southern California Earthquake Center. The first two layers (5.5- and 10.5-km thick) were subdivided into 100 blocks each (12 × 12 km). These layers show a pronounced low-velocity anomaly (24% and 16%, respectively) immediately to the northwest of the epicentral area. This low-velocity zone coincides with the west Ventura Basin. Another pronounced low-velocity zone to the southeast of the epicentral area reflects the presence of the Los Angeles Basin. The locations obtained with the 3D velocity model are consistently to the southeast of the JHD locations, 2.4 km on average. To establish the effect of these pronounced lateral velocity variations on the SEL and JHD locations, synthetic travel times were analyzed. The synthetic times were generated for event locations determined by JHD (shifted by various amounts) and the 3D velocity model and were subsequently treated as the actual data. The most important result of this analysis is that the JHD locations are affected by a quasi-systematic shift in a northwest direction (up to about 2.7 km on average, depending on the initial shift) but that the relative locations are well preserved. Therefore, both the velocity inversion of the actual data and the analysis of the synthetic data indicate that the JHD locations determined for the actual data are quasi-systematically mislocated. To account for this mislocation, an overall shift of 2.5 km to the southeast was applied to all the JHD locations. One of the most important implications of the shifted locations is the possibility that the northeasterly dipping Santa Susana fault, to the northwest of the epicentral area, was seismically active during the aftershock sequence. This feature is more diffuse in other published locations.

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Miller, Catherine R., Nobby C. Mambo, Jianli Dong, and Gerald A. Campbell. "A Case of Previously Unsuspected Huntington Disease Diagnosed at Autopsy." Academic Forensic Pathology 7, no. 1 (March 2017): 136–44. http://dx.doi.org/10.23907/2017.016.

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Huntington disease (HD) is a neurodegenerative disorder with a worldwide prevalence of four to ten per 100 000. It is characterized by choreiform movements, behavioral/psychiatric disturbances, and eventual cognitive decline. Symptoms usually present between 30 and 50 years of age and the diagnosis is based on the combination of clinical symptoms, family history, and genetic testing. A variation of HD, juvenile Huntington disease (JHD), presents earlier, with more severe symptoms and with a worse prognosis. Symptoms are different in JHD, with personality changes and learning difficulties being the predominant presenting features. Seizures are common in JHD, and chorea is uncommon; movement disorders at presentation of JHD are predominantly nonchoreiform. The inheritance pattern for both HD and JHD is autosomal dominant and the disease is caused by an elongation of the CAG repeat in the huntingtin gene. There are many published case reports of Huntington disease that were confirmed at autopsy, but to our knowledge, there are no reports in the literature where the diagnosis of Huntington disease was first made at autopsy. We present a case of a 28-year-old African-American male who was in a state of neglect due to a lifetime of abuse, cognitive difficulties, and seizures, whose cause of death was pneumonia. The gross autopsy findings included bilateral caudate nucleus atrophy and lateral ventricular dilation. Microscopically, severe bilateral neuronal loss and gliosis of the caudate and putamen nuclei were seen. Genetic testing for the number of CAG repeats confirmed the diagnosis and was consistent with JHD.

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Chinen, Kiyomi, and G. Richard Tucker. "Heritage Language Development: Understanding the Roles of Ethnic Identity and Saturday School Participation." Heritage Language Journal 3, no. 1 (September 30, 2005): 27–59. http://dx.doi.org/10.46538/hlj.3.1.2.

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This paper reports on a study of 31 Japanese-American adolescents enrolled in a Saturday Japanese heritage school (JHL) in Los Angeles. The study examined the relationship of the participants’ sense of ethnic identity, attitudes toward the JHL school and self assessed proficiency in Japanese. The major finding of the study, consistent with previous research, was that the variables examined were significantly related. The results also revealed that the older students had a stronger sense of identity as Japanese than the younger students. Moreover, in six months, positive gains were observed in Japanese ethnic identity as Japanese, attitudes toward their JHL school, and self-assessed Japanese proficiency.

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Carter, B. S. "Southern JHKL standards." Monthly Notices of the Royal Astronomical Society 242, no. 1 (February 1, 1990): 1–5. http://dx.doi.org/10.1093/mnras/242.1.1.

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Diatin, I., S. Arifianty, and N. Farmayanti. "Optimation of Production Input in White Shrimp (Litopenaeus vannamei) Culture: A Case Study in UD. Jasa Hasil Diri at Desa Lamaran Tarung, Kecamatan Cantigi, Kabupaten Indramayu." Jurnal Akuakultur Indonesia 7, no. 1 (January 1, 2008): 39. http://dx.doi.org/10.19027/jai.7.39-49.

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<p>UD Jasa Hasil Diri (UD JHD) is a company in Indramayu which culture the white shrimp. UD JHD started this culture in 2003, and now UD JHD's dam out area has reach 26 ha. Total production of white shrimp in 2006 was 125,854.5 kg. The production cost of white shrimp culture that must be spending by UD JHD reached IDR 2,842,427,294. This production cost was allocated to get all variable input such as: seed, food, calcium, fertilizer, vitamin, probiotic, medicine, labor, diesel fuel, and gasoline. The used of production input already in optimum condition. Based on the result of linear study for seed used was optimum at 7,830,667 tails, foods at 204,387.7 kg, calcium at 25,170.9 kg, fertilizer at 503.4 kg, vitamins at 75.5 kg, probiotic at 683.4 kg, medicines at 4,279.1 kg, harvests at 1,258.5 hours, diesel fuel at 104,459.2 liters, and gasoline at 1,200 liters. The cost of production input based on linear study was IDR 2,403,220,000. Thus, UD JHD could reduce this cost by IDR 439,207,294 to get 125,854.5 kg shrimps.</p> <p>Keywords: optimum, production input, cost, white shrimp</p> <p> </p> <p>ABSTRAK</p> <p>UD Jasa Hasil Diri (UD JHD) merupakan sebuah perusahan yang membudidayakan udang vaname di Indramayu. Perusahaan ini memulai usahanya sejak tahun 2003, dan saat ini memiliki tambak seluas 26 ha. Total produksi udang vaname pada tahun 2006 adalah 125.854,5 kg. Biaya yang harus dikelurkan oleh UD JHD untuk memproduksi budidaya udang vaname mencapai Rp. 2.842.427.294. Biaya produksi ini dialokasikan untuk memperoleh berbagai input produksi seperti benur, pakan, kalsium, pupuk, vitamin, probiotik, obat-obatan, tenaga kerja, solar dan bensin. Penggunaan input produksi telah mencapai kondisi optimum. Berdasarkan hasil uji linier, kondisi optimum untuk benih yang ditebar adalah 7.830.667 ekor, pakan sebanyak 204.387,7 kg, kalsium 25.170,9 kg, pupuk 503,4 kg, vitamin 75,5 kg, probiotik 683,4 kg, obat-obatan 4.279,1 kg, masa pemeliharaan 1.258,5 jam, solar 104.459,2 liter, and bensin 1.200 liter. Berdasarkan analisis linier, biaya input produksi adalah Rp. 2.403.220.000. Dengan demikian, UD JHD dapat menurunkan biaya menjadi Rp. 439,207,294 untuk memperoleh 125.854,5 kg udang vaname.</p> <p>Kata kunci: optimum, input produksi, biaya , udang vaname</p>

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15

Pujol, Jose, and Richard Aster. "Joint hypocentral determination and the detection of low-velocity anomalies. An example from the Phlegraean Fields earthquakes." Bulletin of the Seismological Society of America 80, no. 1 (February 1, 1990): 129–39. http://dx.doi.org/10.1785/bssa0800010129.

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Abstract Arrival time data from the Phlegraean Fields (Italy) earthquake swarm recorded by the University of Wisconsin array in 1983 to 1984 were reanalyzed using a joint hypocentral determination (JHD) technique. The P- and S-wave station corrections computed as part of the JHD analysis show a circular pattern of central positive values surrounded by negative values whose magnitudes increase with distance from the center of the pattern. This center roughly coincides with the point of the maximum uplift (almost 2 m) associated with the swarm. Corrections range from −0.85 to 0.10 sec for P-wave arrivals and from −1.09 to 0.70 sec for S-wave arrivals. We interpret these patterns of corrections as caused by a localized low-velocity anomaly in the epicentral area, which agrees with the results of a previous 3-D velocity inversion of the same data set. The relocated (JHD) epicenters show less scatter than the epicenters obtained in the velocity inversion, and move more of the seismic activity to the vicinity of the only presently active fumarolic feature. The capability of the JHD technique to detect low-velocity anomalies and at the same time to give reliable locations, particularly epicenters, was verified using synthetic data generated for a 3-D velocity model roughly resembling the model obtained by velocity inversion.

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Murnane, Megan, Eugen Dhimolea, Ruojing Li, Megan A. Bariteau, Diamond D. Wheeler, Rosemary J. Akhurst, Aaron C. Logan, et al. "Defining Primary Marrow Microenvironment-Induced Synthetic Lethality and Resistance for 2,684 Approved Drugs Across Molecularly Distinct Forms of Multiple Myeloma." Blood 126, no. 23 (December 3, 2015): 503. http://dx.doi.org/10.1182/blood.v126.23.503.503.

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Abstract Multiple Myeloma (MM) is a prototypical neoplasm for the study of tumor-microenvironment interactions and influences on drug response. These interactions within the bone marrow (BM) alter the signaling state of MM cells and their relative dependence on pharmacological targets. Conversely, many efforts to identify and validate drug targets in MM are conducted outside of this context. This raises the possibility that systematic re-evaluation of the current pharmacopeia may identify drugs with previously unappreciated capacity for targeting MM cells within the marrow environment. To this end, we utilized the compartment-specific bioluminescence platform (CS-BLI) to characterize the activity of 2,684 FDA-approved drugs from The Johns Hopkins Drug Library (JHDL) in three distinct MM subtypes, in the presence or absence of patient-derived CD138-negative bone marrow stromal cells (BMSCs). Anti-MM activity was evaluated at 100 nM concentrations over 72 h in MM1S (t(14;16), KRASG12A, TRAF3LOF), L363 (t(20;22), NRASQ61H, p53S261T), and OPM2 (t(4;14), FGFRK560E, p53R175H) lines. These lines demonstrate phenotypes of strong, medium, and low BMSC-induced growth enhancement, respectively. Active drugs were placed into 4 categories: type 1 - having potent anti-MM activity independent of BMSC interactions (no stromal effect), type 2 - having anti-MM activity only in the presence of BMSCs (stroma-dependent "synthetic lethality"), type 3 - having anti-MM activity that is decreased in the context of BMSCs (stroma-dependent resistance), and type 4 - otherwise inactive agents that demonstrate pro-MM activity in context of BMSCs (stroma-dependent stimulants). In this study, for MM1S, L363, and OPM2, respectively, we identified 103, 118, and 108 type 1 drugs, 217, 105, and 76 type 2 drugs, 128, 75, and 16 type 3 drugs, and 124, 33, and 38 type 4 drugs. For each category of drug phenotype, we assessed overlap across the three MM cell lines. We observed high degree of overlap for type 1 drugs (67 drugs active in all three models), while more diversity between lines was evident across the 3 lines for type 2-4 drugs, whose activity is altered by interaction with BMSCs (Figure 1). Specifically, focusing on agents demonstrating BMSC-associated stimulation, adrenergic drugs consistently stimulated MM growth in context of BMSCs, while glucocorticoids consistently grouped as type 3 agents (demonstrating BMSC-associated resistance). Interestingly, carfilzomib was also subject to BMSC-associated resistance. Despite differences in drugs demonstrating stroma-induced lethality across the MM cell lines, salicylates were commonly represented in this category. In addition to the salicylates, tofacitinib, a Janus kinase (JAK) inhibitor, demonstrated a strong capacity to elicit a stroma-dependent synthetic lethal phenotype and ruxolitinib, another inhibitor in the same class, showed a similar, yet distinct pattern of stroma-mediated sensitization. In conjunction with our screen, we performed an RNA-seq analysis to assess differential gene expression between MM in monoculture vs. in co-culture with BMSCs. Expression analysis revealed 4.0 fold increase in JAK3 expression induced by co-culture with primary BMSCs, as well as induction of a STAT3 transcription factor fingerprint by ChIP-seq enrichment analysis. A detailed dose-response analysis of tofacitinib revealed no anti-MM activity against MM cells in isolation at physiological concentrations, but showed typical sigmoidal log-dose response dynamics in the presence of stroma and a dynamic range that completely abrogated the growth advantage attributable to stromal stimulation. This phenomenon of BMSC-dependent pharmacology identifies tofacitinib as an intriguing candidate for repurposing as an agent demonstrating stroma-induced synthetic lethality against MM. Further evaluation of this agent in combination with other anti-MM agents, like bortezomib, is also warranted. Taken together, this study demonstrates specific anti-MM activity for a wide array of clinically relevant drugs and drug classes in the context of BM microenvironment interactions and provides context for further validation and potential suitability for repurposing to treat MM within the medullary compartment. Figure 1. Figure 1. Disclosures Aftab: Cleave Biosciences, Inc.: Research Funding; Omniox, Inc.: Research Funding; Atara Biotherapeutics, Inc.: Employment, Equity Ownership; Onyx Pharmaceuticals, Inc.: Research Funding. Off Label Use: The use of tofacitinib citrate and ruxolitinib will be discussed in preclinical contexts for treatment of multiple myeloma. Other approved drugs and drug classes will be generally presented in similar off-label context..

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Pujol, Jose. "Comments on the joint determination of hypocenters and station corrections." Bulletin of the Seismological Society of America 78, no. 3 (June 1, 1988): 1179–89. http://dx.doi.org/10.1785/bssa0780031179.

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Abstract Some aspects of the joint determination of hypocenters and station corrections (JHD) are discussed. An alternative solution to one of the methods currently in use (Pavlis and Booker, 1983) is proposed. It requires only a modest computational effort and is very fast. This simplification is not achieved at the expense of numerical stability and is backed by a theoretical study of the properties of the matrices involved. These matrices are positive semidefinite, and this allows a general analysis of the JHD solution. Several facts, some of them known and some new, are formally proved. It is possible, for example, to carry out a detailed study of the eigenvalues of the matrix from which the station corrections are derived. It is also shown that the mean value of the initial estimate of station corrections are retained as a bias in the final solution. The relationship between the approximate solution of Frohlich (1979) and the exact JHD solution can also be studied, and the reason for its success in certain cases is explained.

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18

Heinig, Jane. "JHL Notes." Journal of Human Lactation 19, no. 4 (November 2003): 428–29. http://dx.doi.org/10.1177/0890334403194014.

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Heinig, Jane. "JHL Notes." Journal of Human Lactation 20, no. 3 (August 2004): 345. http://dx.doi.org/10.1177/0890334404266879.

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20

Dodgson, Joan E. "JHL News." Journal of Human Lactation 33, no. 3 (July 18, 2017): 478–79. http://dx.doi.org/10.1177/0890334417721709.

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21

Barandovská-Frank, Vera. "Latein." Language Problems and Language Planning 26, no. 2 (August 8, 2002): 179–92. http://dx.doi.org/10.1075/lplp.26.2.06bar.

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Nach dem 18. Jhd. verlor Latein, nach und nach, seine Position als internationale Sprache. Seit der zweiten Hälfte des 20. Jhd. wird es auf mehreren Feldern wiederbelebt. Der Wortschatz wird durch nötige moderne Worte ergänzt, umfangreiche Fachterminare werden erarbeitet, einheitliche Aussprache wird benutzt, es erscheinen moderne Lehrmittel, -programme und -methoden, die zum Lateinsprechen und -schreiben anregen. Außer traditionellen wissenschaftlichen, universitären und schulischen Gebieten pflegen das lebendige Latein verschiedene internationale Organisationen mit vielfältigen Aktivitäten, von wissenschaftlichen Kongressen bis zu lustigen Ferien. Die Sprache funktioniert also als modernes Kommunikationsmittel, obwohl im verminderten Umfang, weil hinter ihr keine ökonomische Macht steht.

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Riekenberg, Michael. "Welche Bedeutungen besaß „politische“ Gewalt in Lateinamerika im 19. Jahrhundert?" arbeitstitel | Forum für Leipziger Promovierende 5, no. 2 (February 25, 2014): 51–52. http://dx.doi.org/10.36258/aflp.v5i2.3272.

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Kotnik-Karuza, D., M. Friedjung, and P. A. Whitelock. "Dust Obscuration Events of the Symbiotic Nova RR Tel in the Near IR." International Astronomical Union Colloquium 194 (2004): 225. http://dx.doi.org/10.1017/s0252921100152716.

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By use of ground based IR photometry, we have studied the dust obscuration events of the symbiotic nova RR Tel which is a binary composed of a cool mira and a hot white dwarf. The JHKL light curves were corrected for Mira pulsations and correlated to the AAVSO visual light curve. We compare the behaviour of the three obscurations in different wavelength bands and propose interpretations of the results.

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Anand, Ruchi, and Ronen Marmorstein. "Structure and Mechanism of Lysine-specific Demethylase Enzymes." Journal of Biological Chemistry 282, no. 49 (September 26, 2007): 35425–29. http://dx.doi.org/10.1074/jbc.r700027200.

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The discovery of histone-demethylating enzymes has revealed yet another reversible histone modification mark. In this review, we describe the structural and chemical insights that we have now derived underlying the activity of these enzymes. The recent co-crystal structures of LSD1 bound to a proparylamine-derivatized histone H3 peptide and JHDM structures bound to two different methylated histone H3 peptides illustrate the steric requirements and structural basis for substrate specificity.

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25

Powers, Diane. "Praise for JHL." Journal of Human Lactation 25, no. 2 (May 2009): 137. http://dx.doi.org/10.1177/0890334409333375.

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26

Antoniou, Alexander-Stamatios, Cary Cooper, and Marilyn Davisdson. "A Qualitative Study Investigating Gender Differences in Primary Work Stressors and Levels of Job Satisfaction in Greek Junior Hospital Doctors." Qualitative Report, January 14, 2015. http://dx.doi.org/10.46743/2160-3715/2008.1588.

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Primary work stressors and job satisfaction/dissatisfaction in Greek Junior Hospital Doctors (JHDs) are investigated to identify similarities and differences in the reports obtained from male and female hospital doctors. Participants in the study included 32 male and 28 female Greek hospital doctors who provided information through semi-structured, in-depth interviews. The findings revealed that a majority of Greek JHDs considered their profession very stressful, and that various differences were identified between male and female JHDs, with regard to perceived stress and satisfaction. The study has implications for the possible introduction of in-house stress management training programmes, both at a generic, and gender specific level. Future research aimed at increasing the individuals’ coping mechanism s, and identifying environmental sources of stress are recommended.

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Mulvey, Nahoko. "Translanguaging as ideology: Responding to social and linguistic diversity in the classroom of Japanese as a heritage language schools in England." Journal of Asian Pacific Communication, October 9, 2020. http://dx.doi.org/10.1075/japc.00066.mul.

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Abstract This paper investigates how ideological orientations shape the programmes and curriculum of Japanese as a heritage language (JHL) schools in England as well as teachers’ practices and attitudes in response to social diversity in such settings. This paper is a result of a linguistic ethnography which explores subjective perspectives constructed locally by people in JHL schools. Japanese communities overseas tend to be regarded as homogenous. However, in the contemporary world of mobility, connectivity and diversity they exhibit heterogeneity. This paper argues that JHL schools emerged as a response to educational needs arising from heterogeneity amongst Japanese migrants and that further diversification is occurring within JHL schools. Consequently, these schools and their teachers need ways to manage diversity in the classroom. Translanguaging is examined as a strategy for inclusion and also as a positive ideological orientation towards differences.

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Lee, Teresa Wei-sy, Heidi Shira David, Amanda Kathryn Engstrom, Brandon Scott Carpenter, and David John Katz. "Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in C. elegans." eLife 8 (December 9, 2019). http://dx.doi.org/10.7554/elife.48498.

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In Caenorhabditis elegans, mutations in WDR-5 and other components of the COMPASS H3K4 methyltransferase complex extend lifespan and enable its inheritance. Here, we show that wdr-5 mutant longevity is itself a transgenerational trait that corresponds with a global enrichment of the heterochromatin factor H3K9me2 over twenty generations. In addition, we find that the transgenerational aspects of wdr-5 mutant longevity require the H3K9me2 methyltransferase MET-2, and can be recapitulated by removal of the putative H3K9me2 demethylase JHDM-1. Finally, we show that the transgenerational acquisition of longevity in jhdm-1 mutants is associated with accumulating genomic H3K9me2 that is inherited by their long-lived wild-type descendants at a subset of loci. These results suggest that heterochromatin facilitates the transgenerational establishment and inheritance of a complex trait. Based on these results, we propose that transcription-coupled H3K4me via COMPASS limits lifespan by encroaching upon domains of heterochromatin in the genome.

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"JHL Notes." Journal of Human Lactation 24, no. 3 (August 2008): 345. http://dx.doi.org/10.1177/0890334408322450.

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"JHL Notes." Journal of Human Lactation 27, no. 1 (January 26, 2011): 81. http://dx.doi.org/10.1177/0890334410396676.

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"JHL News." Journal of Human Lactation 33, no. 4 (October 6, 2017): 652. http://dx.doi.org/10.1177/0890334417726337.

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"JHL Notes." Journal of Human Lactation 20, no. 2 (May 2004): 242. http://dx.doi.org/10.1177/0890334404202018.

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"JHL Notes." Journal of Human Lactation 23, no. 2 (May 2007): 203. http://dx.doi.org/10.1177/0890334407300830.

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"JHL Notes." Journal of Human Lactation 14, no. 2 (June 1998): 165–66. http://dx.doi.org/10.1177/089033449801400225.

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"JHL Notes." Journal of Human Lactation 15, no. 2 (June 1999): 163–64. http://dx.doi.org/10.1177/089033449901500220.

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"JHL Notes." Journal of Human Lactation 18, no. 4 (November 2002): 399. http://dx.doi.org/10.1177/089033402237917.

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"JHL Notes." Journal of Human Lactation 16, no. 1 (February 2000): 65–66. http://dx.doi.org/10.1177/089033440001600114.

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"JHL Notes." Journal of Human Lactation 16, no. 2 (May 2000): 156–57. http://dx.doi.org/10.1177/089033440001600214.

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"JHL Notes." Journal of Human Lactation 16, no. 3 (August 2000): 246. http://dx.doi.org/10.1177/089033440001600314.

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"JHL Notes." Journal of Human Lactation 16, no. 4 (November 2000): 359–60. http://dx.doi.org/10.1177/089033440001600414.

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"JHL Notes." Journal of Human Lactation 17, no. 1 (February 2001): 66. http://dx.doi.org/10.1177/089033440101700112.

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"JHL Notes." Journal of Human Lactation 17, no. 2 (May 2001): 167–68. http://dx.doi.org/10.1177/089033440101700215.

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"JHL Notes." Journal of Human Lactation 17, no. 3 (August 2001): 262–63. http://dx.doi.org/10.1177/089033440101700310.

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"JHL Notes." Journal of Human Lactation 17, no. 4 (November 2001): 350–51. http://dx.doi.org/10.1177/089033440101700410.

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"JHL Notes." Journal of Human Lactation 18, no. 1 (February 2002): 71–72. http://dx.doi.org/10.1177/089033440201800114.

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"JHL Notes." Journal of Human Lactation 18, no. 2 (May 2002): 180–81. http://dx.doi.org/10.1177/089033440201800212.

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"JHL Notes." Journal of Human Lactation 18, no. 3 (August 2002): 282–83. http://dx.doi.org/10.1177/089033440201800313.

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"JHL Notes." Journal of Human Lactation 19, no. 1 (February 2003): 92. http://dx.doi.org/10.1177/0890334402239812.

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"JHL Notes." Journal of Human Lactation 19, no. 2 (May 2003): 205. http://dx.doi.org/10.1177/0890334403192013.

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"JHL Notes." Journal of Human Lactation 19, no. 3 (August 2003): 321. http://dx.doi.org/10.1177/0890334403193014.

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