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1

Rejas, Roberto Anaximandro Garcia. "Expressão das proteinas c-jun, junb, JNK e pc-jun no carcinoma adenóide cístico e carcinoma epidermóide da cavidade bucal." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-06032012-161940/.

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O carcinoma adenóide cístico e o carcinoma epidermóide são neoplasmas de origem epitelial que afetam a cavidade oral. O carcinoma adenóide cístico pode apresentar-se em glândulas salivares maiores e menores, possue alta propensão de invasão perineural e o padrão de infiltracão: sólido, tubular e cribriforme. O carcinoma epidermóide foi descrito como um processo multifatorial envolvendo agentes físicos, químicos e virais, capazes de afetar o metabolismo celular e induzir a proliferação neoplásica. As proteínas c-jun e junB são membros da familia JUN, capazes de homodimerizar ou heterodimerizar
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2

Arnold, Richard Graham. "The role of c-Jun-N-Terminal Kinase (JNK) in hindlimb ischaemia-reperfusion injury." Thesis, Queen's University Belfast, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.579569.

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In spite of improvements in the care of the critically ill patient, both elective and emergency vascular surgical interventions are associated with significant morbidity and mortality. Successful reperfusion of the ischaemic limb often initiates a systemic inflammatory response syndrome (SIRS), which may be complicated by multiple organ failure, including Acute Lung Injury (All) and the Acute Respiratory Distress Syndrome (ARDS). An exaggerated inflammatory response has been shown to play an integral role in the development of ARDS following lower torso or limb ischaemia-reperfusion injury. JN
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Kyula, Joan Nduku. "HSV-1 induced activation of C-JUN-N-Terminal Kinase (JNK) and P38 MAPK." Thesis, Glasgow Caledonian University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413914.

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Yu, Lola. "Investigating the role of the c-Jun NH2-terminal kinase pathway in ErbB2-driven breast cancer and macrophage polarization." eScholarship@UMMS, 2020. https://escholarship.umassmed.edu/gsbs_diss/1094.

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Breast cancer is the second most common malignancy in the world, accounting for over 1.7 million new diagnoses and an estimated 500,000 deaths per year (1). Overexpression of the receptor tyrosine kinase ErbB2, also known as Her2 or Neu, occurs in over 30% of breast cancers and correlates with metastasis, poor prognosis, and decreased survival (1, 2). Although therapeutics targeting ErbB2 show clinical efficacy, many patients display no initial response or develop drug resistance over time (2). A deeper understanding of the molecular basis of ErbB2-driven tumorigenesis is thus required for the
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Gourmaud, Sarah. "Expression de c-Jun N-terminal kinase (JNK) dans la maladie d'Alzheimer : intérêts diagnostiques et thérapeutiques." Paris 7, 2014. http://www.theses.fr/2014PA077106.

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La maladie d'Alzheimer (MA) se caractérise par l'accumulation de peptides d'amyloïde-β42 (Aß₄₂), de protéine tau hyperphosphorylée (ptau) et une perte neuronale. Les niveaux d'Aß₄₂ et de tau au niveau du liquide céphalo-rachidien (LCR) des patients sont utilisés comme biomarqueurs diagnostique. Les protéines PKR et JNK sont des kinases impliquées dans la production d'AE342, la phosphorylation de tau et la mort neuronale. L'accumulation de leur forme active a été mise en évidence dans le cerveau de patients MA. Il existe trois isoformes de JNK. JNK1 et JNK2 sont ubiquitaires et JNK3 est presque
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6

Tonner, Juliane [Verfasser]. "Spezifische Expression von c-Jun N-terminalen Kinasen (JNK) im Nervensystem : eine immunhistochemische Analyse / Juliane Tonner." Kiel : Universitätsbibliothek Kiel, 2009. http://d-nb.info/1019871245/34.

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MacDonald, Jennifer M. "A Role for c-Jun Kinase (JNK) Signaling in Glial Engulfment of Degenerating Axons: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/609.

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The central nervous system (CNS) is composed of two types of cells: neurons that send electrical signals to transmit information throughout the animal and glial cells. Glial cells were long thought to be merely support cells for the neurons; however, recent work has identified many critical roles for these cells during development and in the mature animal. In the CNS, glial cells act as the resident immune cell and they are responsible for the clearance of dead or dying material. After neuronal injury or death, glial cells become reactive, exhibiting dramatic changes in morphology and patterns
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8

Joy, Jery 1992. "Chromosomal instability : interplay between proteotoxic and metabolic stress." Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/668516.

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Chromosomal Instability (CIN) and associated aneuploidy are salient features of the majority of human solid tumors. In the Drosophila epithelial model of CIN, the generation of highly aneuploid karyotypes drive cell delamination and c-Jun N-terminal Kinase (JNK) dependent cell death. Aneuploidy associated generation of Reactive Oxygen Species (ROS) plays a key role in the activation of JNK. When delaminating cells are maintained in the tissue by apoptosis inhibition, aberrant karyotypes promote a cell-autonomous malignant behavior. Here we have dissected the molecular mechanisms under
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9

Alkhoury, Kenan. "Mechanisms responsible for homocysteine mediated damage to human endothelial cells : the role of oxidative stress in atherogenesis." Thesis, University of Bradford, 2009. http://hdl.handle.net/10454/4300.

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Homocysteine (Hcy) has been identified as a primary risk factor for atherosclerosis as it induces endothelial cell (EC) activation/dysfunction and thus potentially initiating atherosclerotic plaque formation. There is accumulating evidence indicating a key role for oxidative stress in mediating Hcy atherogenic effects. The aim of this study was to evaluate the effects of chronic treatment with Hcy on EC activation and to explore the role of oxidative stress in these effects. Human umbilical vein endothelial cells (HUVEC) were cultured and treated chronically with DL-Hcy for 5-9 days. An in vit
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10

Smith, Abigail O. "Defining the Role of c-Jun N-terminal Kinase (JNK) Signaling in Autosomal Dominant Polycystic Kidney Disease." eScholarship@UMMS, 2021. https://escholarship.umassmed.edu/gsbs_diss/1141.

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Polycystic kidney disease is an inherited degenerative disease in which the uriniferous tubules are replaced by expanding fluid-filled cysts that ultimately destroy organ function. Autosomal dominant polycystic kidney disease (ADPKD) is the most common form, afflicting approximately 1 in 1,000 people. It primarily is caused by mutations in the transmembrane proteins Polycystin-1 (PKD1) and Polycystin-2 (PKD2). The most proximal effects of polycystin mutations leading to cyst formation are not known, but pro-proliferative signaling must be involved for the tubule epithelial cells to increase in
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11

Chandley, Michelle J., Katalin Szebeni, Attila Szebeni, et al. "Gene Expression Deficits in Pontine Locus Coeruleus Astrocytes in Men With Major Depressive Disorder." Digital Commons @ East Tennessee State University, 2013. https://doi.org/10.1503/jpn.120110.

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Background: Norepinephrine and glutamate are among several neurotransmitters implicated in the neuropathology of major depressive disorder (MDD). Glia deficits have also been demonstrated in people with MDD, and glia are critical modulators of central glutamatergic transmission. We studied glia in men with MDD in the region of the brain (locus coeruleus; LC) where noradrenergic neuronal cell bodies reside and receive glutamatergic input. Methods: The expression of 3 glutamate-related genes (SLC1A3, SLC1A2, GLUL) concentrated in glia and a glia gene (GFAP) were measured in postmortem tissues
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12

Wang, Fang St George Clinical school UNSW. "Oxidative stress induced C-Jun N-terminal Kinase (JNK) activation in tendon cells upregulates MMP1 mRNA and protein expression." Awarded by:University of New South Wales. St George Clinical school, 2006. http://handle.unsw.edu.au/1959.4/28815.

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To explore the potential mechanisms of tendon degeneration, we investigated the role of c-Jun N-terminal Kinase (JNK) activation and the regulation of matrix metalloproteinase 1 (MMP1) in tendon matrix degradation under oxidative stress. JNK and MMP1 activity in samples from normal and ruptured human supraspinatus tendons were evaluated by immunohistochemistry. Real-time quantitative PCR was utilized to evaluate MMP1 mRNA expression and western blotting for MMP1 and JNK protein detection. JNK activation and increased MMP1 activity were found in the torn human supraspinatus tendon tissue, as we
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Helbig, Lars [Verfasser]. "Aktivierung von c-Jun-N-terminalen Kinasen (SAPK,JNK) als Teil der späten Cisplatin abhängigen DNA-Schadensantwort / Lars Helbig." Mainz : Universitätsbibliothek Mainz, 2013. http://d-nb.info/1034965247/34.

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Nishitani, Kohei. "PGE2 inhibits MMP expression by suppressing MKK4-JNK MAP kinase-c-JUN pathway via EP4 in human articular chondrocytes." Kyoto University, 2010. http://hdl.handle.net/2433/120599.

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15

Jin, Shan Verfasser], and Klaus Jan [Akademischer Betreuer] [Philipp. "Anlehnung und Exploration - die Stadtentwicklung Qingdaos unter der Verwaltung der Republik China (1922 - 1937) / Shan Jin. Betreuer: Klaus Jan Philipp." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2015. http://d-nb.info/1074404998/34.

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Jin, Shan [Verfasser], and Klaus Jan [Akademischer Betreuer] Philipp. "Anlehnung und Exploration - die Stadtentwicklung Qingdaos unter der Verwaltung der Republik China (1922 - 1937) / Shan Jin. Betreuer: Klaus Jan Philipp." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2015. http://d-nb.info/1074404998/34.

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17

Santos, Fernando Reyes, Maggie K. Diamond-Stanic, Mujalin Prasannarong, and Erik J. Henriksen. "The Serine Kinase C-Jun N-Terminal Kinase (JNK) Contributes to Oxidant-Induced Insulin Resistance in Isolated Rat Skeletal Muscle." Thesis, The University of Arizona, 2012. http://hdl.handle.net/10150/244754.

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Insulin resistance of the mammalian skeletal muscle glucose transport system, one cause of which is oxidative stress, leads to the development of type 2 diabetes. While the direct contributions to insulin resistance of certain stress-activated serine kinases have been described previously, the specific contribution of c-Jun N-terminal kinase (JNK) is not fully understood. Therefore, we assessed the role of JNK in insulin resistance caused by in vitro exposure to the oxidant hydrogen peroxide (H₂O₂). Soleus muscles from lean Zucker rats were incubated in low levels (~30 μM) of H₂O₂ in the absen
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18

Henrie, Hélène. "Régulation de la dynamique des microtubules par la kinase de stress JNK dans les cellules épithéliales : caractérisation de CLIP-170 comme un nouveau substrat." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS461/document.

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Les microtubules sont des éléments dynamiques du cytosquelette qui contrôlent à la fois l’organisation du cytoplasme, la polarité, la migration et la division cellulaire. Notre laboratoire a précédemment montré que la kinase de stress JNK (c-Jun NH2-terminal Kinase) régule la dynamique des microtubules dans les cellules épithéliales de mammifères, en augmentant les vitesses de polymérisation, ainsi que les fréquences de sauvetage (transition vers une phase de repolymérisation). Alors que certaines protéines neuronales capables de réguler la dynamique des microtubules ont été identifiées comme
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Elsaesser, Annika. "Proto-oncogene c-jun expression is induced by AML1-ETO in a JNK dependent manner:possible role in the pathogenesis of acute myeloid leukemia." Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-14744.

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Stöcklein, Veit. "Die Rolle des durch die MAP-Kinasen p38 und JNK aktivierten Transkriptionsfaktors c-Jun in Monozyten polytraumatisierter Patienten in der frühen posttraumatischen Phase." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-136552.

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21

Olsson, Philip, and Carl-Johan Jönsson. "Sha Jun." Thesis, Halmstad University, School of Business and Engineering (SET), 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-734.

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<p>The agriculture in Sweden today uses chemical substances to control vermin, weed</p><p>and diseases. This usage shows through polluted subsoil water and trace elements in</p><p>the food we eat. There’s a risk that additional symptoms will arise in the future.</p><p>Our product Sha Jun, developed in 2006-2007, is an attempt to try and minimize the</p><p>need of chemicals in the agriculture. The idea started with the attempt to minimize the</p><p>usage of pesticides on the cropland. It later developed in an attempt to decrease seed</p><p>disinfectant. The spraying with seed disinfectant today
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22

Huys, Janssen Paul. "Jan van Bijlert (1597/98-1671), schilder in Utrecht Jan van Bijlert (1597/97-1671), painter in Utrecht /." Utrecht : University of Utrecht, 1994. http://catalog.hathitrust.org/api/volumes/oclc/31334219.html.

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Zatloukal, Jan Claudon Francis Šrámek Jiří. "L'exil de Jan Čep contribution à l'histoire de la littérature tchèque moderne /." S. l. : S. l. : Paris Est ; Université Palacky Olomouc, 2008. http://doxa.scd.univ-paris12.fr:80/theses/th0493561.pdf.

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Brümmer, Nanke [Verfasser], Martin [Akademischer Betreuer] Banse, Martin [Gutachter] Banse, Achim [Gutachter] Spiller, and Jan-Henning Jun [Gutachter] Feil. "Consumers’ perspective on chicken husbandry: The case of dual-purpose chickens / Nanke Brümmer ; Gutachter: Martin Banse, Achim Spiller, Jan-Henning Jun.- Feil ; Betreuer: Martin Banse." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2019. http://d-nb.info/1188025279/34.

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Roden, Jan [Verfasser], Jan-Michael [Akademischer Betreuer] Rost, and Walter [Akademischer Betreuer] Strunz. "Lichtabsorption und Energietransfer in molekularen Aggregaten / Jan Roden. Gutachter: Jan-Michael Rost ; Walter Strunz. Betreuer: Jan-Michael Rost." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://d-nb.info/1067188827/34.

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Engellau-Gullander, Cecilia Adler Nancy. "Jan II van Coninxlo : a Brussels master of the first half of the 16th Century /." Stockholm : University of Stockholm, Department of Art History, 1992. http://catalogue.bnf.fr/ark:/12148/cb35549435p.

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Franssen, Peter J. A. "Tussen tekst en publiek : Jan van Doesborch, drukker-uitgever en literator te Antwerpen en Utrecht in de eerste helft van de zestiende eeuw /." Amsterdam : Rodopi, 1990. http://catalogue.bnf.fr/ark:/12148/cb355682130.

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Veld, Hendrik van 't. "Beminde broeder die ik vand op 's werelts pelgrims wegen : Jan Luyken (1649-1712) als illustrator en medereiziger van John Bunyan (1628-1688) /." Utrecht : de Banier, 2000. http://catalogue.bnf.fr/ark:/12148/cb38923055f.

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Liang, Zifang. ""Jin zhi yu nie" xi shuo jin ri Xianggang nü xing /." click here to view the abstract and table of contents, 2005. http://net3.hkbu.edu.hk/~libres/cgi-bin/thesisab.pl?pdf=b19816406a.pdf.

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Wong, Sin-i. Elaine. "Ha Jin and the location of representation." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31579899.

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Chan, So Man. "Jin Yong wu xia xiao shuo lian zai ben (1962-1972) yu wen hua da ge ming /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?HUMA%202007%20CHAN.

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Wolff-Thomsen, Ulrike. "Jan Joest von Kalkar : ein niederländischer Maler um 1500 /." Bielefeld : Verlag für Regionalgeschichte, 1997. http://catalogue.bnf.fr/ark:/12148/cb37321968m.

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Peurell, Erik. "En författars väg : Jan Fridegård i det litterära fältet /." Hedemora : Gidlunds, 1998. http://catalogue.bnf.fr/ark:/12148/cb39248607s.

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Cordes, Rudolf. "Jan Zoet, Amsterdammer 1609-1674 : leven en werk van een kleurrijk schrijver /." Hilversum : Verloren, 2008. http://catalogue.bnf.fr/ark:/12148/cb41271550k.

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Au, Ho Vanessa. "Buddhist monks and Daoist priests in Jinyong's "Condor trilogy" Jin Yong "san bu qu" zhong de Seng Dao yan jiu /." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42925848.

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Law, Sze-man. "Deceleration of the narrative flow in the Heaven sword and dragon saber "Yi tian tu long ji" de yan huan xu shi yan jiu /." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43209233.

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Cheng, Hon-leung. "Narrative strategies in the first chapter of the legend of the Condor heroes "She diao ying xiong zhuan" shou hui xu shi ce lüe yan jiu /." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43208642.

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Zhu, Yu, and 朱宇. "Commercial advertisements in Ming Pao (Hong Kong) & Jin Wanbao (Tian Jin)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31225597.

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Steffenson, Becky J. "The Institutionalisation of EU-US relations : decision making, institution building and the new transatlantic agenda." Thesis, University of Glasgow, 2001. http://theses.gla.ac.uk/2232/.

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This thesis represents an attempt to make an original contribution to knowledge about transatlantic institutions and transatlantic governance. It investigates attempts in the 1990s to foster a 'new transatlantic dialogue' between the EU and the US, through three bilateral agreements: the Transatlantic Declaration (1990), the New Transatlantic Agenda (1995) and the Transatlantic Economic Partnership (1998). The thesis questions whether and to what extent the relationship has been institutionalised into a structure for transatlantic governance, and how the composition of transatlantic institutio
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Maroul, Martin. "Jan Křtitel Jiří Neruda." Master's thesis, Akademie múzických umění v Praze. Hudební fakulta AMU. Knihovna, 2008. http://www.nusl.cz/ntk/nusl-78151.

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Kašpar, Lukáš. "Já jsem jen herec." Doctoral thesis, Akademie múzických umění v Praze. Divadelní fakulta AMU. Knihovna, 2009. http://www.nusl.cz/ntk/nusl-78219.

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Throughout my thesis, I will strive to portrait theater acting and manifestation of collaboration and resistance in the field of Czech, Austrian and The German Reich´s theatre (and artin general) as comprehensively as possible. I will attempt to answer the question, whether and how much the Nazis misused this culture area. I cover the activities of theatremakers, filmmakers and plays during 1939-1945, mostly by Nazi propaganda and counter-propaganda by the Allies, I had to know Czech, German and English literature related to the topic, the movies, theatre plays, literature and archive document
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Urban, Vojtěch. "Portrét osobnosti - Jan Vychytil." Master's thesis, Akademie múzických umění v Praze.Hudební a taneční fakulta. Knihovna, 2014. http://www.nusl.cz/ntk/nusl-177864.

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This thesis examines various aspects of Jan Vychytils' personality. Above all, he was a cellist, a teacher and the director of the Music School of Prague. Thus we have three main topics to be talked about: Vychytils artistic interpretation, his pedagogical legacy and a separated chapter is devoted to the Music School of Prague and the circumstances of founding musical classes of Jan Neruda grammar school. In addition, this work captures Jana Vychytil as a poet and a composer in an effort to illustrate his diverse personality.
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Markgraf, Jan Hendrik Verfasser], Jan [Akademischer Betreuer] [Friederichs, Peter [Gutachter] Biberthaler, and Jan [Gutachter] Friederichs. "Rezidivraten und Behandlungsergebnisse von Protheseninfektionen und Osteomyelitiden nach zweizeitiger Revision / Jan Hendrik Markgraf ; Gutachter: Peter Biberthaler, Jan Friederichs ; Betreuer: Jan Friederichs." München : Universitätsbibliothek der TU München, 2018. http://nbn-resolving.de/urn:nbn:de:bvb:91-diss-20180208-1350601-1-4.

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Markgraf, Jan Hendrik [Verfasser], Jan [Akademischer Betreuer] Friederichs, Peter [Gutachter] Biberthaler, and Jan [Gutachter] Friederichs. "Rezidivraten und Behandlungsergebnisse von Protheseninfektionen und Osteomyelitiden nach zweizeitiger Revision / Jan Hendrik Markgraf ; Gutachter: Peter Biberthaler, Jan Friederichs ; Betreuer: Jan Friederichs." München : Universitätsbibliothek der TU München, 2018. http://d-nb.info/1155303326/34.

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Sluss, Hayla Karen. "The c-Jun NH₂-Terminal Kinase Regulates Jun in vitro and in vivo during the Process of Dorsal Closure: A Dissertation." eScholarship@UMMS, 1997. https://escholarship.umassmed.edu/gsbs_diss/264.

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Tyrosine phosphorylation of proteins by protein tyrosine kinases is an important step in initiating mitogenic signal transduction pathways. The receptor tyrosine kinases represent a class of protein kinases that employ phosphorylation cascades to transmit a signal generated at the cell surface. The AP-1 transcription factor is a common target of receptor tyrosine kinase activation, transformation by Ras-like proteins and activation of the MAP kinase pathway. The AP-1 complex contains a dimer of Jun proteins or a heterodimer of Jun and Fos or other bZip proteins. The transcriptional activation
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Munz, Christine-Luise. "Molekulare Mechanismen der transkriptionellen Aktivierung durch die Transkriptionsfaktoren c-Jun und v-Jun." [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=961463430.

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Stöcklein, Veit [Verfasser], and Peter [Akademischer Betreuer] Biberthaler. "Die Rolle des durch die MAP-Kinasen p38 und JNK aktivierten Transkriptionsfaktors c-Jun in Monozyten polytraumatisierter Patienten in der frühen posttraumatischen Phase / Veit Stöcklein. Betreuer: Peter Biberthaler." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2011. http://d-nb.info/101816362X/34.

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Lu, Chin-chung, and 呂志忠. "NA-Men’s Son-Jun Jin." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/59450980470756221019.

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碩士<br>國立臺南大學<br>台灣文化研究所<br>93<br>Na-Men Village is an area that has very low produce production with underdeveloped business and industry. Therefore, there is a high ratio of population leaving and reside other places each year. However, whenever there are celebrations of the birth of Kuan-Yin and Buddha, people will come back to participate and host the art of Jin-Tou, which is a form of religious rituals and dance. Combined with the partnership of Bureau of Tourism, the squad of Na-Men Jin-Tou and Food and Tourism hosted Taiwan’s twelve international folk cultural festivities. This even
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Chan, Yushin, and 詹育欣. "The role of c-Jun N-terminal kinase (JNK)." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/60142941903169660454.

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碩士<br>長庚大學<br>基礎醫學研究所<br>92<br>Paclitaxel is one of the microtubule-active agents. It interacts with β-tubulin, stabilzes the microtubule structure and thus alters the microtubule dynamics, resulting in the G2/M phase arrest. After a prolonged G2/M arrest, cells undergo apoptosis. Paclitaxel also activates JNK/SAPK (c-Jun N-terminal kinases/stress-activated protein kinases) and the activated JNK further phosphorylates c-Jun, a transcription factor, regulating downstream genes expression. JNK activation is required for the early phase of paclitaxel-induced apoptosis. However, the exact role
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Hidding, Ute Maria Antonia. "Die Rolle von c-Jun N-terminalen Kinasen (JNK) in mikrogliären Zellkulturen." 2005. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=014906349&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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