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Journal articles on the topic 'Jneneh'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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1

Mayyas, Abdulraouf, Khaled Douglas, Mahmoud Al-Qudah, Fardous Al-Ajlouny, and Dima Kreshan. "Lipid markers in archaeological pottery vessels excavated at Jneneh Site, in North-Central Jordan." Journal of Archaeological Science: Reports 43 (June 2022): 103410. http://dx.doi.org/10.1016/j.jasrep.2022.103410.

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2

Vermette, M. G., and S. F. Perry. "The effects of prolonged epinephrine infusion on the physiology of the rainbow trout, Salmo gairdneri. II. Branchial solute fluxes." Journal of Experimental Biology 128, no. 1 (1987): 255–67. http://dx.doi.org/10.1242/jeb.128.1.255.

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Rainbow trout were infused continuously for 24 h with epinephrine in order to elevate circulating levels to those measured during periods of acute extracellular acidosis (about 5 X 10(−8) mol l-1). Concomitant effects on branchial solute fluxes were evaluated. Epinephrine infusion caused complex and differential adjustments of Na+ and Cl- unidirectional fluxes (influx and efflux) resulting in a significant elevation of the arithmetic difference between Na+ and Cl- net fluxes (JnetNa+-JnetCl-). A significant correlation existed between JnetNa+-JnetCl- and net branchial acid excretion (JnetH+),
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3

Sobel, Raymond A. "Editor’s Note: Transitions at the JNEN." Journal of Neuropathology & Experimental Neurology 76, no. 5 (2017): 336. http://dx.doi.org/10.1093/jnen/nlx019.

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4

Slama-Ayed, Olfa, Imen Bouhaouel, Sourour Ayed, Jacques De Buyser, Emmanuel Picard, and Hajer Slim Amara. "Efficiency of three haplomethods in durum wheat (Triticum turgidum subsp. durum Desf.): isolated microspore culture, gynogenesis and wheat × maize crosses." Czech Journal of Genetics and Plant Breeding 55, No. 3 (2019): 101–9. http://dx.doi.org/10.17221/188/2017-cjgpb.

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This study presents the first report comparing the efficiency of microspore culture, gynogenesis and durum wheat × maize crosses for haploid plant production from three durum wheat genotypes (Razzek, Karim and Jneh Khotifa). The results showed that the best induction, calli or embryos formation and plant regeneration rates for the three genotypes were obtained with gynogenesis (47.2, 7.6, 0.8%), followed by interspecific crosses (33.1, 1.7, 0.4%) and isolated microspore culture (8.2, 0.05, 0.01%). Interestingly, all plants regenerated by gynogenesis and durum wheat × maize crosses were green w
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5

Lascarro Navarro, Frank David, Elías Ernesto Rojas Martínez, and Dino Carmelo Manco Jaraba. "CORRELACIÓN GENÉTICA DE LOS EVENTOS MAGMÁTICOS TRIÁSICO – JURÁSICO Y LA FORMACIÓN NOREAN." REVISTA AMBIENTAL AGUA, AIRE Y SUELO 13, no. 2 (2022): 90–103. http://dx.doi.org/10.24054/raaas.v13i2.2733.

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La Formación Noreán, reconocida también como “Unidad Volcanoclástica de Noreán”, ampliamente distinguida por presentar rocas que datan del 158±12 y 144±4 Ma (pre-Cretácica) con el mayor registro volcánico en Colombia, su origen se encuentra asociado a condiciones ambientales de acumulaciones detríticas continentales de hasta 4500 metros de espesor, que demuestran un fuerte magmatismo por la presencia de diques y silos (en ocasiones con presencia de minerales estratégicos, como malaquita). Constituida por una secuencia de rocas detríticas continentales de coloración rojiza, con intercalaciones
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6

Creekmore, Benjamin C., Yi-Wei Chang, and Edward B. Lee. "The Cryo-EM Effect: Structural Biology of Neurodegenerative Disease Aggregates." Journal of Neuropathology & Experimental Neurology 80, no. 6 (2021): 514–29. http://dx.doi.org/10.1093/jnen/nlab039.

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Abstract Neurogenerative diseases are characterized by diverse protein aggregates with a variety of microscopic morphologic features. Although ultrastructural studies of human neurodegenerative disease tissues have been conducted since the 1960s, only recently have near-atomic resolution structures of neurodegenerative disease aggregates been described. Solid-state nuclear magnetic resonance spectroscopy and X-ray crystallography have provided near-atomic resolution information about in vitro aggregates but pose logistical challenges to resolving the structure of aggregates derived from human
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7

Scholl, Theresa, Victoria-Elisabeth Gruber, Sharon Samueli, et al. "Neurite Outgrowth Inhibitor (NogoA) Is Upregulated in White Matter Lesions of Complex Cortical Malformations." Journal of Neuropathology & Experimental Neurology 80, no. 3 (2021): 274–82. http://dx.doi.org/10.1093/jnen/nlaa159.

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Abstract Complex cortical malformations (CCMs), such as hemimegalencephaly and polymicrogyria, are associated with drug-resistant epilepsy and developmental impairment. They share certain neuropathological characteristics including mammalian target of rapamycin (mTOR) activation and an atypical number of white matter neurons. To get a better understanding of the pathobiology of the lesion architecture, we investigated the role of neurite outgrowth inhibitor A (NogoA), a known regulator of neuronal migration. Epilepsy surgery specimens from 16 CCM patients were analyzed and compared with sectio
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8

Covelli, Claudia, Paola Parente, Nadia Icolaro, et al. "Primary Epithelioid Hemangioma of the Central Nervous System: A Case Report and Review of the Literature." Journal of Neuropathology & Experimental Neurology 80, no. 7 (2021): 717–19. http://dx.doi.org/10.1093/jnen/nlaa163.

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9

Szewczyk, Barbara, René Günther, Jared Sterneckert, Susanne Petri, Florian Wegner, and Andreas Hermann. "FUS Is Not Mislocalized in Spinal Motor Neurons Derived From Human Induced Pluripotent Stem Cells of Main Non-FUS ALS Subtypes." Journal of Neuropathology & Experimental Neurology 80, no. 7 (2021): 720–22. http://dx.doi.org/10.1093/jnen/nlaa154.

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10

Richardson, Timothy E., Kimmo J. Hatanpaa, and Jamie M. Walker. "Molecular Characterization of “True” Low-Grade IDH-Wildtype Astrocytomas." Journal of Neuropathology & Experimental Neurology 80, no. 5 (2021): 431–35. http://dx.doi.org/10.1093/jnen/nlab023.

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Abstract Numerous recent studies have demonstrated that the vast majority of IDH-wildtype astrocytomas with WHO grade II/III histology have clinical outcomes equivalent to IDH-wildtype glioblastomas. This has called into question the existence of an IDH-wildtype lower-grade astrocytoma (LGA) category, and the cIMPACT-NOW study group has suggested 3 molecular features which, if present, warrant upgrading IDH-wildtype LGA to glioblastoma: EGFR amplification, 7+/10−, and TERT promoter mutation. Herein, we evaluate the clinical, histologic, and molecular features of IDH-wildtype low-grade astrocyt
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11

Stephen Nix, J., and Cristiane M. Ida. "What Every Neuropathologist Needs to Know: Practical Aspects and Pitfalls in Molecular Diagnosis of Brain Tumors." Journal of Neuropathology & Experimental Neurology 80, no. 5 (2021): 415–18. http://dx.doi.org/10.1093/jnen/nlab033.

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Abstract Molecular testing has become part of the routine diagnostic workup of brain tumors after the implementation of integrated histomolecular diagnoses in the 2016 WHO classification update. It is important for every neuropathologist to be aware of practical preanalytical, analytical, and postanalytical factors that impact the performance and interpretation of molecular tests. Prior to testing, optimizing tumor purity and tumor amount increases the ability of the molecular test to detect the genetic alteration of interest. Recognizing basic molecular testing platform analytical characteris
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12

Russo, Camilla, Giuseppe Pontillo, Francesco Saccà, et al. "Nonvascular Parkinsonism in Fabry Disease: Results From Magnetic Resonance and Dopamine Transporter Imaging." Journal of Neuropathology & Experimental Neurology 80, no. 5 (2021): 476–79. http://dx.doi.org/10.1093/jnen/nlab030.

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13

Adle-Biassette, Homa. "Neurodevelopmental Sequelae of Preterm Infants: Scientific Challenges." Journal of Neuropathology & Experimental Neurology 80, no. 5 (2021): 390–92. http://dx.doi.org/10.1093/jnen/nlab035.

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14

Brock, Stefanie, Alex Michotte, Elisa Doné, et al. "Novel Variant in COL4A1 Causes Extensive Prenatal Intracranial Hemorrhage and Porencephaly." Journal of Neuropathology & Experimental Neurology 80, no. 8 (2021): 807–10. http://dx.doi.org/10.1093/jnen/nlab026.

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15

Creekmore, Benjamin C., Yi-Wei Chang, and Edward B. Lee. "The Cryo-EM Effect: Structural Biology of Neurodegenerative Disease Proteostasis Factors." Journal of Neuropathology & Experimental Neurology 80, no. 6 (2021): 494–513. http://dx.doi.org/10.1093/jnen/nlab029.

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Abstract Neurodegenerative diseases are characterized by the accumulation of misfolded proteins. This protein aggregation suggests that abnormal proteostasis contributes to aging-related neurodegeneration. A better fundamental understanding of proteins that regulate proteostasis may provide insight into the pathophysiology of neurodegenerative disease and may perhaps reveal novel therapeutic opportunities. The 26S proteasome is the key effector of the ubiquitin-proteasome system responsible for degrading polyubiquitinated proteins. However, additional factors, such as valosin-containing protei
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16

Walker, Jamie M., Yelena Fudym, Kurt Farrell, et al. "Asymmetry of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer Disease." Journal of Neuropathology & Experimental Neurology 80, no. 5 (2021): 436–45. http://dx.doi.org/10.1093/jnen/nlab032.

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Abstract Primary age-related tauopathy (PART) is a neurodegenerative entity defined as neurofibrillary degeneration generally restricted to the medial temporal region (Braak stage I–IV) with complete or near absence of diffuse and neuritic plaques. Symptoms range in severity but are generally milder and later in onset than in Alzheimer disease (AD). Recently, an early predilection for neurofibrillary degeneration in the hippocampal CA2 subregion has been demonstrated in PART, whereas AD neuropathologic change (ADNC) typically displays relative sparing of CA2 until later stages. In this study,
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17

Gambetti, Pierluigi. "Autobiography Series: A Life of Anecdotes." Journal of Neuropathology & Experimental Neurology 80, no. 6 (2021): 608–23. http://dx.doi.org/10.1093/jnen/nlab021.

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18

Corrà, Marta Francisca, Mafalda Sousa, Inês Reis, et al. "Advantages of an Automated Method Compared With Manual Methods for the Quantification of Intraepidermal Nerve Fiber in Skin Biopsy." Journal of Neuropathology & Experimental Neurology 80, no. 7 (2021): 685–94. http://dx.doi.org/10.1093/jnen/nlab045.

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Abstract Intraepidermal nerve fiber density (IENFD) measurements in skin biopsy are performed manually by 1–3 operators. To improve diagnostic accuracy and applicability in clinical practice, we developed an automated method for fast IENFD determination with low operator-dependency. Sixty skin biopsy specimens were stained with the axonal marker PGP9.5 and imaged using a widefield fluorescence microscope. IENFD was first determined manually by 3 independent observers. Subsequently, images were processed in their Z-max projection and the intradermal line was delineated automatically. IENFD was
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19

Koga, Shunsuke, Nikhil B. Ghayal, and Dennis W. Dickson. "Deep Learning-Based Image Classification in Differentiating Tufted Astrocytes, Astrocytic Plaques, and Neuritic Plaques." Journal of Neuropathology & Experimental Neurology 80, no. 4 (2021): 306–12. http://dx.doi.org/10.1093/jnen/nlab005.

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Abstract This study aimed to develop a deep learning-based image classification model that can differentiate tufted astrocytes (TA), astrocytic plaques (AP), and neuritic plaques (NP) based on images of tissue sections stained with phospho-tau immunohistochemistry. Phospho-tau-immunostained slides from the motor cortex were scanned at 20× magnification. An automated deep learning platform, Google AutoML, was used to create a model for distinguishing TA in progressive supranuclear palsy (PSP) from AP in corticobasal degeneration (CBD) and NP in Alzheimer disease (AD). A total of 1500 images of
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20

Schindelmann, Kim Hannah, Fabienne Paschereit, Alexandra Steege, Gisela Stoltenburg-Didinger, and Angela M. Kaindl. "Systematic Classification of Spina Bifida." Journal of Neuropathology & Experimental Neurology 80, no. 4 (2021): 294–305. http://dx.doi.org/10.1093/jnen/nlab007.

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Abstract Spina bifida (SB) is an umbrella term for multiple conditions characterized by misclosure of vertebral arches. Neuropathologic findings in SB cases are often reported with imprecise and overlapping terminology. In view of the increasing identification of SB-associated genes and pathomechanisms, the precise description of SB subtypes is highly important. In particular, the term “myelomeningocele” is applied to various and divergent SB subtypes. We reevaluated 90 cases with SB (58 prenatal; 32 postnatal). The most frequent SB phenotype in our cohort was myeloschisis, which is characteri
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21

Ulloa-Navas, María José, Luis Rubio, Anna Teruel-Sanchis, et al. "Heterogeneous Pattern of Differentiation With BCAS1/NABC1 Expression in a Case of Oligodendroglioma." Journal of Neuropathology & Experimental Neurology 80, no. 4 (2020): 379–83. http://dx.doi.org/10.1093/jnen/nlaa144.

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22

Kisby, Glen E., Jason L. Eriksen, Anna C. Chlebowski та Peter S. Spencer. "Cycad Genotoxin Methylazoxymethanol Disrupts the Brain Ubiquitin-Proteasome Pathway, Tau and α-Synuclein, as Reported in ALS-PDC". Journal of Neuropathology & Experimental Neurology 80, № 3 (2021): 286–88. http://dx.doi.org/10.1093/jnen/nlab006.

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23

Pryzbylski, Amber L., Thomas M. Kollmeyer, Corinne E. Praska, et al. "Non-canonical IDH Mutation Frequency in IDH1-R132H-Negative Glioblastoma Patients Older Than 54 Years." Journal of Neuropathology & Experimental Neurology 80, no. 8 (2021): 804–6. http://dx.doi.org/10.1093/jnen/nlab004.

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24

Dahl, Nathan A., Andrew M. Donson, Bridget Sanford, et al. "NTRK Fusions Can Co-Occur With H3K27M Mutations and May Define Druggable Subclones Within Diffuse Midline Gliomas." Journal of Neuropathology & Experimental Neurology 80, no. 4 (2021): 345–53. http://dx.doi.org/10.1093/jnen/nlab016.

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Abstract Diffuse midline gliomas (DMGs) are incurable pediatric tumors with extraordinarily limited treatment options. Decades of clinical trials combining conventional chemotherapies with radiation therapy have failed to improve these outcomes, demonstrating the need to identify and validate druggable biologic targets within this disease. NTRK1/2/3 fusions are found in a broad range of pediatric cancers, including high-grade gliomas and a subset of DMGs. Phase 1/2 studies of TRK inhibitors have demonstrated good tolerability, effective CNS penetration, and promising objective responses across
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25

Richardson, Timothy E., Adwait Amod Sathe, Chao Xing, et al. "Molecular Signatures of Chromosomal Instability Correlate With Copy Number Variation Patterns and Patient Outcome in IDH-Mutant and IDH-Wildtype Astrocytomas." Journal of Neuropathology & Experimental Neurology 80, no. 4 (2021): 354–65. http://dx.doi.org/10.1093/jnen/nlab008.

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Abstract Chromosomal instability due to mutations in genes guarding the stability of the genome is a well-known mechanism underlying tumorigenesis and malignant progression in numerous cancers. The effect of this process in gliomas is mostly unknown with relatively little research examining the effects of chromosomal instability on patient outcome and therapeutic efficacy, although studies have shown that overall/total copy number variation (CNV) is elevated in higher histologic grades and in cases with more rapid progression and shorter patient survival. Herein, we examine a 70-gene mRNA expr
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Napoletani, Giorgia, Daniele Vigli, Livia Cosentino, et al. "Stimulation of the Serotonin Receptor 7 Restores Brain Histone H3 Acetylation and MeCP2 Corepressor Protein Levels in a Female Mouse Model of Rett Syndrome." Journal of Neuropathology & Experimental Neurology 80, no. 3 (2021): 265–73. http://dx.doi.org/10.1093/jnen/nlaa158.

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Abstract Rett syndrome (RTT) is a rare neurological disorder caused by mutations in the X-linked MECP2 gene, characterized by severe behavioral and physiological impairments for which no cure is available. The stimulation of serotonin receptor 7 (5-HT7R) with its selective agonist LP-211 (0.25 mg/kg/day for 7 days) was proved to rescue neurobehavioral alterations in a mouse model of RTT. In the present study, we aimed at gaining insight into the mechanisms underpinning the efficacy of 5-HT7R pharmacological stimulation by investigating its epigenetic outcomes in the brain of RTT female mice be
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27

Bieniek, Kevin F., Nigel J. Cairns, John F. Crary, et al. "The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy." Journal of Neuropathology & Experimental Neurology 80, no. 3 (2021): 210–19. http://dx.doi.org/10.1093/jnen/nlab001.

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Abstract Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder associated with exposure to head trauma. In 2015, a panel of neuropathologists funded by the NINDS/NIBIB defined preliminary consensus neuropathological criteria for CTE, including the pathognomonic lesion of CTE as “an accumulation of abnormal hyperphosphorylated tau (p-tau) in neurons and astroglia distributed around small blood vessels at the depths of cortical sulci and in an irregular pattern,” based on review of 25 tauopathy cases. In 2016, the consensus panel met again to review and refine the preliminary cr
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28

Smith, Miriam J., Omar N. Pathmanaban, David J. Coope, Andrew T. King, and D. Gareth Evans. "Comment on: SMARCB1 Gene Mutation Predisposes to Earlier Development of Glioblastoma: A Case Report of Familial GBM." Journal of Neuropathology & Experimental Neurology 80, no. 3 (2021): 289–90. http://dx.doi.org/10.1093/jnen/nlaa105.

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29

Miyake, Yohei, Keita Fujii, Taishi Nakamaura, et al. "IDH-Mutant Astrocytoma With Chromosome 19q13 Deletion Manifesting as an Oligodendroglioma-Like Morphology." Journal of Neuropathology & Experimental Neurology 80, no. 3 (2021): 247–53. http://dx.doi.org/10.1093/jnen/nlaa161.

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Abstract Partial deletions in chromosomes 1p and 19q are found in a subset of astrocytic tumors; however, it remains unclear how these alterations affect their histological features and prognosis. Herein, we present 3 cases of isocitrate dehydrogenase (IDH)-mutant astrocytoma with chromosome 19q13 deletion. In the first case, the primary tumor harbored an IDH1 mutation with chromosome 1p/19q partial deletions, which covered 19q13 and exhibited a durable initial response to radiotherapy and temozolomide (TMZ) treatment. However, the tumor lost the chromosome 1p/19q partial deletions at recurren
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Fonkem, Ekokobe, Sen Peng, Michael Berens, and Sanjib Mukherjee. "Authors’ Reply: SMARCB1 Gene Mutation Predisposes to Earlier Development of Glioblastoma: A Case Report of Familial GBM." Journal of Neuropathology & Experimental Neurology 80, no. 3 (2021): 290–91. http://dx.doi.org/10.1093/jnen/nlaa105.001.

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31

Ferrer, Isidro, Pol Andrés-Benito, Margarita Carmona, Abdelilah Assialioui, and Mónica Povedano. "TDP-43 Vasculopathy in the Spinal Cord in Sporadic Amyotrophic Lateral Sclerosis (sALS) and Frontal Cortex in sALS/FTLD-TDP." Journal of Neuropathology & Experimental Neurology 80, no. 3 (2021): 229–39. http://dx.doi.org/10.1093/jnen/nlaa162.

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Abstract Sporadic amyotrophic lateral sclerosis (sALS) and FTLD-TDP are neurodegenerative diseases within the spectrum of TDP-43 proteinopathies. Since abnormal blood vessels and altered blood-brain barrier have been described in sALS, we wanted to know whether TDP-43 pathology also occurs in blood vessels in sALS/FTLD-TDP. TDP-43 deposits were identified in association with small blood vessels of the spinal cord in 7 of 14 cases of sALS and in small blood vessels of frontal cortex area 8 in 6 of 11 FTLD-TDP and sALS cases, one of them carrying a GRN mutation. This was achieved using single an
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Nichols, Jodie B., Michael Malek-Ahmadi, Pierre N. Tariot, Geidy E. Serrano, Lucia I. Sue та Thomas G. Beach. "Vascular Lesions, APOE ε4, and Tau Pathology in Alzheimer Disease". Journal of Neuropathology & Experimental Neurology 80, № 3 (2021): 240–46. http://dx.doi.org/10.1093/jnen/nlaa160.

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Abstract We sought to determine the associations among cerebral amyloid angiopathy (CAA), white matter rarefaction (WMR), circle of Willis atherosclerosis (CWA), and total microinfarct number with Braak neurofibrillary stage in postmortem individuals with and without Alzheimer disease (AD). Data from 355 cases of autopsied individuals with Braak stage I–VI who had antemortem consensus diagnoses of cognitively unimpaired (n = 183), amnestic mild cognitive impairment (n = 31), and AD dementia (n = 141) were used. The association between Braak stage and vascular lesions were individually assessed
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Sieben, Anne, Tim Van Langenhove, Yannick Vermeiren, et al. "Hippocampal Sclerosis in Frontotemporal Dementia: When Vascular Pathology Meets Neurodegeneration." Journal of Neuropathology & Experimental Neurology 80, no. 4 (2021): 313–24. http://dx.doi.org/10.1093/jnen/nlab010.

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Abstract Hippocampal sclerosis (HS) is a common neuropathological finding and has been associated with advanced age, TDP-43 proteinopathy, and cerebrovascular pathology. We analyzed neuropathological data of an autopsy cohort of early-onset frontotemporal dementia patients. The study aimed to determine whether in this cohort HS was related to TDP-43 proteinopathy and whether additional factors could be identified. We examined the relationship between HS, proteinopathies in frontotemporal cortices and hippocampus, Alzheimer disease, cerebrovascular changes, and age. We confirmed a strong associ
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Bouman, Karlijn, Benno Küsters, Josine M. De Winter, et al. "NEM6, KBTBD13-Related Congenital Myopathy: Myopathological Analysis in 18 Dutch Patients Reveals Ring Rods Fibers, Cores, Nuclear Clumps, and Granulo-Filamentous Protein Material." Journal of Neuropathology & Experimental Neurology 80, no. 4 (2021): 366–76. http://dx.doi.org/10.1093/jnen/nlab012.

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AbstractNemaline myopathy type 6 (NEM6), KBTBD13-related congenital myopathy is caused by mutated KBTBD13 protein that interacts improperly with thin filaments/actin, provoking impaired muscle-relaxation kinetics. We describe muscle morphology in 18 Dutch NEM6 patients and correlate it with clinical phenotype and pathophysiological mechanisms. Rods were found in in 85% of biopsies by light microscopy, and 89% by electron microscopy. A peculiar ring disposition of rods resulting in ring-rods fiber was observed. Cores were found in 79% of NEM6 biopsies by light microscopy, and 83% by electron mi
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Li, Yu-Qing, and C. Shun Wong. "Metabolic Regulation of Hippocampal Neuronal Development and Its Inhibition After Irradiation." Journal of Neuropathology & Experimental Neurology 80, no. 5 (2021): 467–75. http://dx.doi.org/10.1093/jnen/nlab014.

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Abstract 5′-Adenosine monophosphate-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis, plays a role in cell fate determination. Whether AMPK regulates hippocampal neuronal development remains unclear. Hippocampal neurogenesis is abrogated after DNA damage. Here, we asked whether AMPK regulates adult hippocampal neurogenesis and its inhibition following irradiation. Adult Cre-lox mice deficient in AMPK in brain, and wild-type mice were used in a birth-dating study using bromodeoxyuridine to evaluate hippocampal neurogenesis. There was no evidence of AMPK or phospho
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Danielsen, Travis, Christopher Hauch, Leon Kelly, and Charles L. White. "Chronic Traumatic Encephalopathy (CTE)-Type Neuropathology in a Young Victim of Domestic Abuse." Journal of Neuropathology & Experimental Neurology 80, no. 6 (2021): 624–27. http://dx.doi.org/10.1093/jnen/nlab015.

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Kelly, Sarah C., Peter T. Nelson, and Scott E. Counts. "Pontine Arteriolosclerosis and Locus Coeruleus Oxidative Stress Differentiate Resilience from Mild Cognitive Impairment in a Clinical Pathologic Cohort." Journal of Neuropathology & Experimental Neurology 80, no. 4 (2021): 325–35. http://dx.doi.org/10.1093/jnen/nlab017.

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Abstract Locus coeruleus (LC) neurodegeneration is associated with cognitive deterioration during the transition from normal cognition to mild cognitive impairment (MCI) and Alzheimer disease (AD). However, the extent to which LC degenerative processes differentiate cognitively normal, “resilient” subjects bearing a high AD pathological burden from those with MCI or AD remains unclear. We approached this problem by quantifying the number of LC neurons and the percentage of LC neurons bearing AT8 tau pathology, TDP-43 pathology, or a marker for DNA/RNA oxidative damage, in well-characterized su
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Pham, Khoa, Micah J. Maxwell, Heather Sweeney, et al. "Novel Glutamine Antagonist JHU395 Suppresses MYC-Driven Medulloblastoma Growth and Induces Apoptosis." Journal of Neuropathology & Experimental Neurology 80, no. 4 (2021): 336–44. http://dx.doi.org/10.1093/jnen/nlab018.

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Abstract Medulloblastoma is the most common malignant pediatric brain tumor. Amplification of c-MYC is a hallmark of a subset of poor-prognosis medulloblastoma. MYC upregulates glutamine metabolism across many types of cancer. We modified the naturally occurring glutamine antagonist 6-diazo-5-oxo-l-norleucine (DON) by adding 2 promoeities to increase its lipophilicity and brain penetration creating the prodrug isopropyl 6-diazo-5-oxo-2-(((phenyl (pivaloyloxy) methoxy) - carbonyl) amino) hexanoate, termed JHU395. This prodrug was shown to have a 10-fold improved CSF-to-plasma ratio and brain-to
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Pérez-López, Natalia, Carla Martín, Beatriz García, et al. "Alterations in the Expression of the Genes Responsible for the Synthesis of Heparan Sulfate in Brains With Alzheimer Disease." Journal of Neuropathology & Experimental Neurology 80, no. 5 (2021): 446–56. http://dx.doi.org/10.1093/jnen/nlab028.

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Abstract The saccharide chains of heparan sulfate appear to be involved in several aspects Alzheimer disease (AD) pathogenesis. Their structural complexity is due to the expression of different isoenzymes. We studied the differential transcription of heparan sulfate chain biosynthesis in AD brains, analyzing different brain regions in patients with different extents of AD pathology. The transcriptomic study was performed by RT-PCR using samples of amygdala, anterior hippocampus, posterior hippocampus, claustrum, calcarine fissure, globus pallidus and cerebellum from patients with mild, moderat
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Kostović, Ivica, Milan Radoš, Mirna Kostović-Srzentić, and Željka Krsnik. "Fundamentals of the Development of Connectivity in the Human Fetal Brain in Late Gestation: From 24 Weeks Gestational Age to Term." Journal of Neuropathology & Experimental Neurology 80, no. 5 (2021): 393–414. http://dx.doi.org/10.1093/jnen/nlab024.

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Abstract During the second half of gestation, the human cerebrum undergoes pivotal histogenetic events that underlie functional connectivity. These include the growth, guidance, selection of axonal pathways, and their first engagement in neuronal networks. Here, we characterize the spatiotemporal patterns of cerebral connectivity in extremely preterm (EPT), very preterm (VPT), preterm and term babies, focusing on magnetic resonance imaging (MRI) and histological data. In the EPT and VPT babies, thalamocortical axons enter into the cortical plate creating the electrical synapses. Additionally,
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Mayyas, Abdulraouf. S. "ORGANIC RESIDUES IN ANCIENT POTTERY SHERDS FROM SITES IN JORDAN." November 28, 2017. https://doi.org/10.5281/zenodo.1069524.

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This paper discusses the analysis of organic residues preserved in the fabric of twelve pottery sherds (two Bronze Age and ten Iron Age) excavated from three sites: Jneneh, Sahab and Tell Abu al-Kharaz. Gas chromatography-mass spectrometry was used for separation and identification of organic constituents. Conventional solvent extraction was used for the extraction of residues preserved in their fabrics. The analysis showed that five sherds out of the twelve preserve significant organic constituents derived from plant and animal sources. The results inform that plant oil (most likely olive oil
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Mayyas, Abdulraouf S., and Khaled A. Douglas. "ORGANIC RESIDUES IN IRON AGE II POTTERY VESSELS FROM JNENEH, JORDAN." May 1, 2015. https://doi.org/10.5281/zenodo.18356.

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This paper discusses the analysis and occurrence of organic residues in Iron Age II pottery sherds excavated at the site of Jneneh. Gas chromatography – mass spectrometry was used for separation and identification of organic constituents. Conventional solvent extraction and alkaline hydrolysis (saponification) were used for the extraction of residues preserved in their fabrics. Three sherds among six unwashed and unhandled sherds showed significant preservation of organic constituents derived from natural materials. The results provide data on the occurrence of beeswax that could have be
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Hunziker-Rodewald, Regine, and Khaled A. Douglas. "Performance Frozen in Time: A New Iron Age II Female Ceramic Figurine from Jneneh, North Central Jordan." Bulletin of the American Schools of Oriental Research, September 22, 2021, 000. http://dx.doi.org/10.1086/716546.

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Yde, Jacob C., Kai Finster, Teresa G. Bárcena, and Niels Tvis Knudsen. "Er vi alene i universet? - fra Jens Lyn til Astrobiologi." GeologiskNyt, no. 4 (August 1, 2009). http://dx.doi.org/10.7146/gn.v0i4.3519.

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<div>Et af de helt store videnskabelige og eksistentielle spørgsmål er, om der er liv andre steder end på Jorden – og hvis der er, hvilke livsformer kan vi så forvente at møde, og hvor skal vi i givet fald lede efter det. I første omgang må vi rette øjnene mod vores egen planet, hvor vi stadig overraskes af især mikroorganismers tilpasning til ekstreme livsbetingelser.</div>
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Hart, Michael N. "The AANP, JNEN, and Me." Journal of Neuropathology & Experimental Neurology, April 21, 2023. http://dx.doi.org/10.1093/jnen/nlad023.

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"Acknowledgement of Manuscript Reviewers JNEN Volume – 6 (2020)." Journal of Neurology and Experimental Neuroscience 6, no. 2 (2020): 69–70. http://dx.doi.org/10.17756/jnen.2020-079.

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"Acknowledgement of Manuscript Reviewers JNEN Volume – 7 (2021)." Journal of Neurology and Experimental Neuroscience 07, no. 02 (2021). http://dx.doi.org/10.17756/jnen.2021-091.

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"Acknowledgement of Manuscript Reviewers JNEN Volume-2 (2016)." Journal of Neurology and Experimental Neuroscience 02, no. 02 (2016). http://dx.doi.org/10.17756/jnen.2016-017.

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"Acknowledgement of Manuscript Reviewers JNEN Volume-3 (2017)." Journal of Neurology and Experimental Neuroscience 03, no. 02 (2017). http://dx.doi.org/10.17756/jnen.2018-031.

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"Acknowledgement of Manuscript Reviewers JNEN Volume-4 (2018)." Journal of Neurology and Experimental Neuroscience 04, no. 02 (2018). http://dx.doi.org/10.17756/jnen.2018-044.

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