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1

DeRousseau, C. Jean. Osteoarthritis in rhesus monkeys and gibbons: A locomotor model of joint degeneration. Karger, 1988.

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2

Zika Virus Disease. Exon Publications, 2024. http://dx.doi.org/10.36255/zika-virus-disease.

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Zika Virus Disease is a mosquito-borne illness that can cause mild symptoms such as fever, rash, and joint pain but is particularly concerning for its potential to cause severe birth defects and neurological complications. This article provides a detailed understanding of Zika Virus Disease, serving as a valuable resource for the public. The article begins with an introduction to the virus, explaining its origins and primary modes of transmission. It covers the causes of infection, including how the virus is transmitted by mosquitoes and other methods. The article discusses the different strai
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3

Aspden, Richard, and Jenny Gregory. Morphology. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0011.

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The study of joint morphology can help us to understand the risk factors for osteoarthritis (OA), how it progresses, and aids in developing imaging biomarkers for study of the disease. OA results in gross structural changes in affected joints. Growth of osteophytes, deformation of joint components, and loss of joint space where cartilage has broken down are all characteristics of the disorder. Certain bone shapes as well as malalignment predispose people to future OA, or may be a marker for early OA. Geometrical measures, such as the alpha angle or Wiberg’s CE angle, used to be the primary too
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4

Eder, Lihi. The clinical course and outcome of psoriatic arthritis. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198737582.003.0021.

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In contrast to early reports, it is now appreciated that psoriatic arthritis (PsA) can present as a destructive, progressive, and disabling arthritis with consequences as severe as those of rheumatoid arthritis. Longitudinal cohort studies of PsA patients contributed important knowledge about long-term outcomes, such as development of structural joint damage, remission achievement, and physical function. These studies identified predictors for improved outcomes including male gender and lower burden of inflammation at presentation while delayed diagnosis, disability, and joint damage are assoc
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5

Long, William J., and Giles R. Scuderi. Total knee replacement. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199550647.003.008006.

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6

de Vlam, Kurt. Overview of psoriatic arthritis pathogenesis. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198737582.003.0004.

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Psoriatic arthritis (PsA) is a chronic inflammatory arthritis occurring in patients with psoriasis. Some consider it as part of the heterogeneous group of diseases unified in the concept of spondyloarthritis (SpA). At least some subtypes, such as the oligoarticular and axial subtypes, can be classified as SpA. The aetiology and pathogenesis are poorly understood. An enthesitis-based model was proposed to unify skin and joint manifestation and to differentiate PsA from other rheumatic diseases such as rheumatoid arthritis and osteoarthritis. The development of PsA results from the interplay of
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7

Computational Biomechanics Of The Wrist Joint. Springer, 2012.

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8

Breban, Maxime, and Hill Gaston. Immune mechanisms: adaptive immunity. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198734444.003.0008.

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The role of adaptive immunity (i.e. the involvement of B and T lymphocytes) in the pathogenesis of axial spondyloarthritis has been investigated in both human disease and relevant animal models. Studies of B cell responses have not generally implicated an autoantibody in the disease, but there are abnormalities of antibody responses, particularly increased titres of antibodies to various gut bacteria. T cells are critical to the disease in animal models other than those where overexpression of a cytokine is engineered, suggesting that they are the drivers of the inflammatory response. There is
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9

Tillett, William, and Neil McHugh. Plain radiography. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198737582.003.0016.

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Psoriatic arthritis is a destructive inflammatory arthritis that can affect the peripheral and axial skeleton of patients with psoriasis. Plain radiography has formed an important part in defining psoriatic arthritis as a distinct clinical entity, from early work reporting on distinguishing features to more recent inclusion of osteoproliferation in the CASPAR classification criteria. Plain radiography is accessible, inexpensive and remains the standard measure of assessing damage in inflammatory arthritis. Originally considered a benign disease psoriatic arthritis is now recognised to be destr
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10

Zachar, Peter, and Robert F. Krueger. Personality Disorder and Validity. Edited by K. W. M. Fulford, Martin Davies, Richard G. T. Gipps, et al. Oxford University Press, 2013. http://dx.doi.org/10.1093/oxfordhb/9780199579563.013.0052.

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This chapter describes the introduction of the concept of personality in the late nineteenth and early twentieth century as a secularization and medicalization of the notion of character. This secularization served as the key prelude to the initiation of the scientific study of personality traits. It also examines the origins of the concept of personality disorder in psychiatry's rejection of the disease-based concept of the degenerate, morbid personality. After setting the historical stage, the chapter explores three validity-related issues. The first is a question about what role values shou
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11

Thomas, Ranjeny, and Andrew P. Cope. Pathogenesis of rheumatoid arthritis. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0109.

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In depth molecular and cellular analysis of synovial tissue and fluid from patients with rheumatoid arthritis has provided important insights into understanding disease pathogenesis. Advances in the 1980s and 1990s included modern cloning strategies, sensitive and specific assays for inflammatory mediators, production of high-affinity neutralizing monoclonal antibodies, advances in flow cytometry, and gene targeting and transgenic strategies in rodents. In the 21st century, technological platforms offer unparalleled opportunities for systematic and unbiased interrogation of the disease process
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12

Rowe, Stephen C. Overcoming America / America Overcoming. The Rowman & Littlefield Publishing Group, 2021. https://doi.org/10.5040/9781666999945.

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In this new edition of Overcoming America / America Overcoming, Stephen Rowe shows how the COVID-19 pandemic in tandem with Trumpism have brought basic dynamics of the American situation to high relief, and hence provide opportunity to address them – before it is too late. The dynamics he identifies are those of moral disease and political paralysis as symptomatic of the fact that America herself has been overtaken by the modern values which she exported to the rest of the world. He points to a way out of the current and potentially fatal malaise and violence: join other societies which are al
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13

IX Congress with international participation Control and prevention of infections associated with health care (HAIs-2021). Central Research Institute for Epidemiology, 2021. http://dx.doi.org/10.36233/978-5-6045286-5-5.

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The significant prevalence of healthcare associated infections (HAIs) in medical organizations of various profiles, its negative impact on the health of patients and the outcomes of the underlying disease, the increasing duration of treatment with the addition of HAIs have determined their relevance at all times. Ensuring the epidemiological safety of healthcare activities requires the introduction of new methods of prevention into epidemiological practice, which can only be implemented from the standpoint of an interdisciplinary approach, the joint participation of professionals of various sp
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14

Hospitals in Integrated Health Service Delivery Networks: Strategic Recommendations. Pan American Health Organization, 2021. http://dx.doi.org/10.37774/9789275120040.

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In 2007, PAHO launched the Integrated Health Service Delivery Network (IHSDN) initiative to address the problems derived from the fragmentation of health services and to overcome the structural problems stemming from the widespread segmentation of health systems in the countries of the Region. In the IHSDN initiative, hospitals are an aggregate of specialized institutions that support a highly effective first level of care. Hospitals themselves are defragmented, which is theoretically correct, innovative, and even visionary. However, the IHSDN initiative does not seek to diminish the influence
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15

Mease, Philip. Biologic treatments for psoriatic arthritis apart from TNF inhibition. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198737582.003.0030.

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Psoriatic arthritis (PsA) is an immunologically mediated inflammatory disease characterized by arthritis, enthesitis, dactylitis, spondylitis, and psoriasis. Prior to the introduction of targeted biologic medications, such as TNF inhibitors, the ability to control disease activity was limited, with only modest effects noted with traditional oral medications such as methotrexate and sulfasalazine. The introduction of TNF inhibitors substantially changed the outlook of PsA patients, yielding significant response in all relevant clinical domains and demonstrating the ability to inhibit progressiv
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16

Pool, Robert. Beyond Engineering. Oxford University Press, 1997. http://dx.doi.org/10.1093/oso/9780195107722.001.0001.

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We have long recognized technology as a driving force behind much historical and cultural change. The invention of the printing press initiated the Reformation. The development of the compass ushered in the Age of Exploration and the discovery of the New World. The cotton gin created the conditions that led to the Civil War. Now, in Beyond Engineering, science writer Robert Pool turns the question around to examine how society shapes technology. Drawing on such disparate fields as history, economics, risk analysis, management science, sociology, and psychology, Pool illuminates the complex, of
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