Relevant bibliographies by topics / JOINT DISEASES; DIAGNOSIS

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'JOINT DISEASES; DIAGNOSIS'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 February 2022

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Journal articles on the topic "JOINT DISEASES; DIAGNOSIS"

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F. Fasanelo Gomes, Luanna, and Stefano C. Filippo Hagen. "Ultrasonography diagnosis of joint diseases in dogs – review." Clínica Veterinária XXIV, no. 139 (March 1, 2019): 54–65. http://dx.doi.org/10.46958/rcv.2019.xxiv.n.139.p.54-65.

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Ultrasonography is not frequently used in the evaluation of the musculoskeletal system of dogs. During the last three decades this imaging technique has been shown to be valuable in the diagnosis and monitoring the musculoskeletal disorders of human patients. Ultrasonography allows recognitions of different anatomical joint structures and enables detection of lesions in tendons, ligaments, joint capsule, cartilage, meniscus and bone surfaces. The diagnostic value of the technique is highly operator-dependent, and can be influenced by the difficult to access to some anatomical structures. In spite of its limitations, the availability and low cost of the ultrasonography can make it an important tool in the assessment of musculoskeletal disorders in dogs.
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Zimmerli, Werner. "Prosthetic joint infection: Diagnosis and treatment." Current Infectious Disease Reports 2, no. 5 (October 2000): 377–79. http://dx.doi.org/10.1007/s11908-000-0059-z.

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Abdushukurova, Kamila. "DIAGNOSIS OF OSTEOPOROSIS WITH RHEUMATOID ARTHRITIS." Doctor's Herald/ Доктор ахборотномаси /Вестник врача 93, no. 1 (March 30, 2020): 8–10. http://dx.doi.org/10.38095/2181-466x-2020931-8-10.

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Rheumatoid arthritis (RA) is a chronic joint disease with erosive and destructive lesions of the peripheral joints. The incidence of RA is 10% for rheumatic diseases and 0.5-1.0% in the general population. Women get sick 3-6 times more often than men
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Gomez-Urena, Eric O., Aaron J. Tande, Douglas R. Osmon, and Elie F. Berbari. "Diagnosis of Prosthetic Joint Infection." Infectious Disease Clinics of North America 31, no. 2 (June 2017): 219–35. http://dx.doi.org/10.1016/j.idc.2017.01.008.

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Chichasova, N. V. "Differential diagnosis in joint and spine damages." Modern Rheumatology Journal 14, no. 2 (May 30, 2020): 14–19. http://dx.doi.org/10.14412/1996-7012-2020-2-14-19.

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The lecture covers main approaches to differential diagnosis in rheumatic diseases. It highlights the key questions that should be answered at the primary examination of the patient. The most important signs that can identify severe, sometimes urgent nonrheumatic diseases are presented. The author describes pain of different patterns and intensity and the most common variants of acute or chronic onset of mono-, oligo-, or polyarthritis. The 2016 European League Against Rheumatism (EULAR) definition of arthralgia suspicious for the development of rheumatoid arthritis is given. The lecture presents the signs indicating the inflammatory nature of back pain in cases of suspected spondyloarthritis (SpA), as well as a two-step diagnostic strategy for axial SpA. Attention is paid to the semiotics of joint damage and extra-articular manifestations in various rheumatic diseases. A brief algorithm for a differential diagnostic search for joint pain is given.
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Stevanović, Oliver, Maciej Janeczek, Aleksander Chrószcz, and Nemanja Marković. "Joint Diseases in Animal Paleopathology: Veterinary Approach." Macedonian Veterinary Review 38, no. 1 (March 1, 2015): 5–12. http://dx.doi.org/10.14432/j.macvetrev.2014.10.024.

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Abstract Animal paleopathology is not a very well known scientific discipline within veterinary science, but it has great importance for historical and archaeological investigations. In this paper, authors attention is focused on the description of one of the most common findings on the skeletal remains of animals - osteoarthropathies. This review particularly emphasizes the description and classification of the most common pathological changes in synovial joints. The authors have provided their observations on the importance of joint diseases in paleopathology and veterinary medicine. Analysis of individual processes in the joints of the animals from the past may help in the understanding of diseases in modern veterinary medicine. Differential diagnosis was made a point of emphasis and discussion, so that this work could have practical significance for paleopathology and veterinary medicine.
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Kamosko, Mikhail Mikhailovich, and Mahmoud Stanislavovich Poznovich. "Radiological diagnosis of hip joint abnormalities in children." Pediatric Traumatology, Orthopaedics and Reconstructive Surgery 3, no. 2 (June 15, 2015): 32–41. http://dx.doi.org/10.17816/ptors3232-41.

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Abnormalities of the hip joint in children covers a wide range of diseases, including both congenital and acquired ones. Hip dysplasia, Legg-Calve-Perthes disease and juvenile slipped capital femoral epiphysis account for up to 25 % of all diseases of the musculoskeletal system in pediatric patients. Early diagnosis of these disorders and timely treatment are of paramount importance in the prevention of childhood disability.
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Kim, E. Edmund. "Combined Scintigraphic and Radiographic Diagnosis of Bone and Joint Diseases." Journal of Nuclear Medicine 59, no. 2 (December 21, 2017): 347. http://dx.doi.org/10.2967/jnumed.117.206698.

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Kim, E. E. "Combined Scintigraphic and Radiographic Diagnosis of Bone and Joint Diseases." Journal of Nuclear Medicine 54, no. 7 (May 24, 2013): 1168–69. http://dx.doi.org/10.2967/jnumed.113.126557.

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Butt, Paul. "Combined scintigraphic and radiographic diagnosis of bone and joint diseases." Current Orthopaedics 10, no. 3 (July 1996): 209–10. http://dx.doi.org/10.1016/s0268-0890(96)90031-6.

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Dissertations / Theses on the topic "JOINT DISEASES; DIAGNOSIS"

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Fietz, Simone Angelika. "Biomarkers in equine synovial fluid and serum for the diagnosis of joint diseases /." Berlin : Mensch-und-Buch-Verl, 2008. http://d-nb.info/992999545/04.

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Woodley, Stephanie Jane, and n/a. "Lateral hip pain : an anatomical and clinical study." University of Otago. Department of Anatomy & Structural Biology, 2006. http://adt.otago.ac.nz./public/adt-NZDU20061206.162321.

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Lateral hip pain (LHP), characterised by non-specific symptoms in the region of the greater trochanter, is a condition frequently encountered by physiotherapists and other health professionals. However, the pathogenesis of LHP is not well understood. Although pathology of the gluteal tendons and their associated bursae have long been implicated in the cause of this problem, trochanteric bursitis has emerged as the primary clinical diagnosis. In order to determine a differential diagnosis, clinicians are reliant on information collated from the patient history and physical examination, yet the validity of many of the tests used to diagnose LHP has not been established. Abnormalities of the gluteal bursae may give rise to LHP and therefore to ensure precision of clinical assessment and treatment techniques, knowledge of bursal morphology is essential. However, a review of the literature revealed that there are no complete morphological accounts of all the bursae in this area. Therefore, the main purposes of this study were (a) to determine the morphology of the bursae associated with the greater trochanter and (b) to examine the physiotherapy and radiological diagnoses of LHP, and the validity of selected tests used in the diagnosis of LHP. In the anatomical study, the bursae deep to each of the layered gluteal tendons were examined in 21 embalmed human hips (9 male, 12 female; mean age 79 years, SD 9.4 years) using macro-dissection and histological techniques. Morphological associations, size, positions and histological characteristics of the bursae were recorded. A total of 121 bursae were identified in ten different locations, with an average of six bursae per hip. Variation was evident, but it was typical that at least two bursae were found deep to gluteus maximus (GMax) and the fascia lata, and gluteus medius (GMed). In approximately two-thirds of specimens a single bursa was situated deep to the tendon of gluteus minimus (GMin). All of these bursae demonstrated a synovial lining, which was predominantly areolar in type. This study revealed that numerous bursae are intimately associated with the greater trochanter, and provides new morphological detail which is of significance when considering clinical and biomechanical models of LHP. A clinical study was undertaken whereby 40 consecutive patients (37 female, 3 male; mean age 54.4 years, SD 9.5 years) with unilateral LHP were recruited prospectively. Each eligible participant underwent a standardised physiotherapy assessment followed by a magnetic resonance (MR) imaging study of the pelvis and both hips. The MR images were analysed in random order by three radiologists blinded to clinical findings and symptomatic side, and the intra-and inter-observer reliability for image analysis was examined using the kappa statistic. To determine the validity of selected clinical tests as evaluated against MR imaging, sensitivity, specificity, and positive and negative likelihood ratios (LRs) were calculated, and the chi-squared test was used to determine association. As demonstrated by MR imaging, GMed tendon pathology, bursitis, osteoarthritis (OA) and gluteal muscle atrophy are all associated with the report of LHP. Interestingly, these various pathologies were identified in asymptomatic as well as symptomatic limbs. However, while bursitis was equally prevalent in symptomatic and asymptomatic hips, GMed tendon pathology and OA were observed more frequently on the symptomatic side. Furthermore, muscle atrophy which predominantly affected GMin, was specific to symptomatic hips. Large variation was evident in the strength of agreement between radiologists and there was little agreement between physiotherapy and radiological diagnoses of pathology. Physiotherapists frequently diagnosed trochanteric bursitis as a cause of LHP and while palpation was identified as the most provocative test for reproducing patients complaint of LHP, it was not shown to be a valid technique. Instead, the outcomes pertaining to the validity of the clinical tests indicate that attention should be focused towards the assessment and treatment of gluteal tendon pathology. The two tests that appeared to be most useful for diagnosing gluteal tendon pathology were pain reproduction with passive hip abduction and resisted testing of GMed and GMin. While these findings demonstrate that various pathologies are associated with the report of LHP, they also highlight some problems associated with the use of MR imaging as a reference standard. Before further clinical validation studies of LHP are undertaken in larger populations, it is recommended that verification of MR imaging outcomes are performed against surgical and histological findings.
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Fietz, Simone Angelika [Verfasser]. "Biomarkers in equine synovial fluid and serum for the diagnosis of joint diseases / Simone Angelika Fietz." Berlin : Freie Universität Berlin, 2009. http://d-nb.info/102358154X/34.

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Björnsdóttir, Sigrídur. "Bone spavin in Icelandic horses : aspects of predisposition, pathogenesis and prognosis /." Uppsala : Dept. of Clinical Radiology, Swedish Univ. of Agricultural Sciences ([Institutionen för klinisk radiologi], Sveriges lantbruksuniv, 2002. http://epsilon.slu.se/avh/2002/91-576-6382-3.pdf.

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Lee, Tse-kwan Louisa, and 李芷筠. "Diagnostic subtypes, psychological distress and psychosocial dysfunction in southern Chinese patients with Temporomandibulardisorders." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B39849119.

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Nicholas, Richard Stephen. "High-resolution magnetic resonance imaging of diurnal variations in rheumatoid arthritis." Thesis, University of Exeter, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341167.

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Costa, Emanuel Dias. "Prevalência de alterações radiográficas associadas à doença articular degenerativa no gato doméstico : estudo retrospetivo de 100 casos." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2018. http://hdl.handle.net/10400.5/16330.

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Dissertação de Mestrado Integrado em Medicina Veterinária
A doença articular degenerativa (DAD) apresenta uma etiologia multifatorial, envolvendo fatores genéticos, biomecânicos e bioquímicos, caracterizando-se pela existência de degeneração da cartilagem articular com produção de novo tecido ósseo. A sua prevalência na população felina parece aumentar com a idade, sendo o seu diagnóstico feito com base na associação de sinais clínicos e alterações ao exame radiográfico. O presente estudo teve por base uma amostra de 100 pacientes felinos (N=100) com exame radiográfico e anamnese disponíveis. Os objetivos principais foram calcular a prevalência de DAD na presente amostra e avaliar a frequência e a gravidade das lesões no esqueleto axial e apendicular. Para isto, os exames radiográficos dos 100 animais foram avaliados por dois observadores quanto à existência de sinais radiográficos compatíveis com DAD e respetivo grau de gravidade. Na população avaliada, a prevalência de sinais radiográficos compatíveis com DAD foi de 38%. Os esqueletos apendicular e axial apresentaram alterações em 24% e 25% dos animais, respetivamente. Existiam lesões simultaneamente na coluna e nas articulações apendiculares em 11% dos animais avaliados. A articulação do esqueleto apendicular mais frequentemente afetada foi a articulação úmero-rádio-ulnar, e a que apresentou lesões de maior gravidade foi a articulação femoro-tíbio-patelar. No esqueleto axial, o segmento da coluna com maior frequência de alterações compatíveis com DAD foi a região torácica. Já a região lombar apresentou scores de gravidade mais elevados quando comparado com os restantes segmentos. Não foi encontrada uma associação estatisticamente significativa entre a presença de sinais radiográficos e o sexo ou a idade. No entanto, foi encontrada uma relação estatisticamente significativa entre a raça do animal e a presença de DAD (p<0,05). A prevalência encontrada (38%) é largamente superior ao número de animais da amostra em que se suspeitava da existência de doença articular (3%). Além de frequente, a DAD é sub-diagnosticada na prática clínica, sendo responsável por provocar dor crónica nos pacientes felinos passando muitas vezes desapercebida quando a avaliação se baseia na anamnese e nos sinais clínicos. Sendo assim, o exame radiográfico e sua correta apreciação reveste-se de extrema importância de modo a identificar e possibilitar o tratamento desta doença.
ABSTRACT - Prevalence of radiographic changes associated with degenerative joint disease in the domestic cat – retrospective study of 100 cases - Degenerative joint disease (DJD) has a multifactorial etiology that involves genetics, biomechanics and biochemistry factors and it is characterized by the degeneration of the cartilage with production of new bone tissue. Its prevalence in the feline population increases with age and its diagnosis takes in consideration the clinical signs as well the radiographic chances. The present study used a sample of 100 feline patients (N=100) with radiographic exams and anamnesis available. The main objective was to calculate DJD prevalence in the sample as well as determine the frequency and severity of these lesions in the axial and appendicular skeleton. To accomplish this, radiographic exams from 100 patients were observed and evaluated by two different observers, who assessed them for the presence of radiographic signs compatible with DJD and respective degree of severity. In the evaluated population, the prevalence of radiographic signs compatible with DJD was 38%. The appendicular and axial skeleton had shown changes in 24% and 25% of the animals, respectively. There were lesions in both spine and appendicular joints in 11% of the population. The most frequently affected joint of the appendicular skeleton was the elbow, and the one that presented with the most severe lesions was the knee. In what concerns to the axial skeleton, the segment of the spine with the highest frequency of compatible with DJD was the thoracic region. The lumbar region presented higher severity scores when compared to the other segments. No statistically significant association was found between the presence of radiographic signs and sex or age. However, a statistically significant relationship was found between the patient’s breed and the presence of DJD (p<0,05. The prevalence of DJD determined (38%) is significantly higher than the number of patients in which it was suspected (3%). DJD is not only frequent and responsible for causing chronic pain in feline patients, but also under-diagnosed in the clinical practice, going unnoticed when the evaluation is based on anamnesis and clinical signs. Therefore, the radiographic examination and its correct evaluation is of extreme importance to identify and make the treatment of this disease possible.
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Mendonça, José Alexandre 1969. "O ultrassom articular = uma ferramenta importante de avaliação no diagnóstico na artrite reumatóide inicial." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310630.

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Orientador: Manoel Barros Bértolo
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-18T22:39:29Z (GMT). No. of bitstreams: 1 Mendonca_JoseAlexandre_D.pdf: 2535796 bytes, checksum: 374639057a45bad9800020693b3bc4de (MD5) Previous issue date: 2011
Resumo: Objetivo: Avaliar sinovite pelo ultrassom (US) articular em pacientes com artrite reumatóide (AR) inicial e correlacionar com os dados clínicos, radiográficos e laboratoriais. Pacientes e Métodos: Este estudo avaliou 832 articulações de 32 pacientes (24 mulheres e 8 homens) com AR inicial selecionados no período de 2008 a 2010 do ambulatório de artrite da Universidade Estadual de Campinas, caracterizado por 20 (62.5%) caucasóides e 12 (37.5%) não caucasóides; um tempo médio de doença de 13 meses, com média de idade de 42 anos. Nesta amostra foram detectadas, pelas escalas semiquantitativas cinza (SG) e pelo power Doppler (PD), 173 articulações com sinovite de grau 0 a 3. Foi usado um ultrassom GE LOGIQ XP-linear de alta frequência (8-10 MHz). Todas as mãos foram radiografadas e analisadas pelo score de Larsen com variação de grau entre 0 a V. Resultados: Este estudo evidenciou correlações significativas e positivas entre os dados ultrassonográficos, clínicos e laboratoriais: SGUS e PDUS do punho D e PCR (r=0.41 a 0.42), SGUS do 3ªMTF D, 4ªMTF D com o HAQ - DI (r=0.37 a 0.38), SGUS do 4ªMTF E e o PCR (r=0.42), SGUS do 2ªMTF D e o FR (r=0.40), SGUS-Score 7mod com o DAS28 (PCR) (r=0.38) e o PDUS-Score 7mod com o PCR (r=0.39). Houve correlações significativas negativas com o SGUS 2ªMTCF D com a dose e o tempo de uso MTX (r=-0.36 a -0.37). O PCR nesta amostra pode ser considerado um indicador de atividade inflamatória quando existe sinovite detectada pelo US. Conclusão: A utilização do US mostrou ser uma importante ferramenta na avaliação de AR inicial e dá um suporte mais seguro no diagnóstico para iniciativas terapêuticas mais precisas e seletivas
Abstract: This study evaluated 832 joints of 32 patients (24 women and 8 men) with early RA enrolled for the period 2008 to 2010 of the arthritis clinic of the Universidade Estadual de Campinas (UNICAMP), characterized by 20 (62.5%) Caucasians, 12 (37.5%) non-Caucasians, an average disease was 13 months, with a mean age of 42 years. This sample was detected by semi-quantitative gray scale (GS) and power Doppler (PD) 173 joints with synovitis of degree 0 to 3. It was used a GE LOGIQ XP-linear ultrasound and high frequency (8-10 MHz) transducer. All hands were X-rayed and analyzed by the Larsen score, with grades ranging from 0 to V. This study showed positive and significant correlation between sonographic, clinical and laboratory data: GSUS/PDUS of right wrist and CRP (r = 0.41 to 0.42), GSUS of the right 3ºMTP, GSUS of the right 4ºMTP and HAQ - DI (r = 0.37 to 0.38), GSUS of the left 4ºMTP and CRP (r = 0.42), GSUS of the right 2ºMTP and FR (r = 0.40), GSUS 7mod-score with the DAS28 (CRP) (r = 0.38) and PDUS 7mod-Score to CRP (r = 0.39). There was a significant negative correlation with the right 2ºMCP with dose and duration of MTX use (r = -0.36 to -0.37). The CRP in this sample can be considered an indicator of inflammatory activity, when analyzed separately or with all the joints committed. Using the US was an important tool in the evaluation of RA and gives a more secure support for initiatives in the diagnosis and treatment more precise and selective
Doutorado
Clinica Medica
Doutor em Clínica Médica
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Veiga, Ana Carolina Rocha. "Estudo retrospectivo de casuística, abrangendo metodologia diagnóstica da osteoartrite em eqüinos." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/10/10136/tde-16052007-091454/.

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Nos eqüinos, as articulações sinoviais são submetidas a graus variáveis de estresse físico, de acordo com o tipo de movimento executado. Com o trabalho ou treinamento intenso, o aumento da carga imposta aos seus tecidos pode provocar sinovite mecanicamente induzida, com produção e liberação de citocinas, e conseqüentemente estimulação de metaloproteinases e de outros componentes inflamatórios. Estes eventos podem acarretar em desequilíbrio entre os processos de síntese e degradação de proteoglicanos e glicosaminoglicanos da matriz cartilagínea, levando a osteoartrite. Perante a magnitude de ocorrência de osteoartrite em eqüinos atletas, teve-se como objetivo caracterizar a população de cavalos, com diagnóstico firmado de osteoartrite, atendida junto ao Serviço de Clínica Médica de Eqüinos do Hospital Veterinário (HOVET) da Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ/USP), em um período de 10 anos. O levantamento da casuística foi executado através da análise de fichas de registro dos casos antigos. A amostragem foi composta envolvendo a totalidade de casos de eqüídeos, com diagnóstico firmado da doença articular, arrolando-se e analisando-se dados referentes a: espécie, idade, sexo, peso, raça, atividade esportiva, início e evolução da doença, tipo de manifestação clínica, e exames radiográficos. Foram analisados 152 prontuários de eqüídeos acometidos por osteoartrite. Observou-se que a maioria tratava-se de animais da espécie eqüina, com idade média de 8 anos, macho ou fêmea, das raças Quarto de Milha, Mangalarga Paulista e sem raça definida, pesando em torno de 420kg, praticantes de romaria ou provas de Quarto de Milha.O tempo médio entre o início da sintomatologia de osteoartrite e o atendimento hospitalar foi de 7,7 meses.A análise estatística não mostrou relação entre presença de claudicação, dor palpável, sensibilidade em casco, sensibilidade muscular, teste de flexão positiva e atividade exercida (p>0,05). Porém, mostrou correlação entre a presença de edema/calor e atividade exercida (p<0,05). Também não mostrou relação entre dor palpável, edema/calor, sensibilidade de casco, sensibilidade muscular, e claudicação (p>0,05). Mediante os resultados obtidos pela avaliação radiográfica dos pacientes acometidos por osteoartrite, notou-se que não houve relação direta entre o menor e maior escore em relação à presença ou não de claudicação. Concluiu-se que o perfil do paciente, acometido por osteoartrite, mais freqüentemente atendido pelo Serviço de Clínica Médica de Eqüinos ? HOVET ? USP trata-se da espécie eqüina, da raça Quarto de Milha, 8 anos de idade, 420 kg, praticante de provas de Quarto de Milha.
The equine sinovial joints are submitted do different degrees of physical stress, depending on the movement performed. With work and hard training, the increase on the loads applied to its tissues maycause mechanically induced synovitis, with production and release of cytokines, and consequently metalloproteinases stimulation and other inflammatory components. These events may lead to anunbalance between the synthesis and degradation processes, of proteoglycan and glicosaminoglycan of the cartilaginous matrix, leading to the osteoarthritis. Regarding the magnitude of the osteoarthritis incidence on athletic horses, our goal is to characterize the horse population with confirmed osteoarthritis diagnoses examined by the Equine Internal Medicine Service at the Veterinary Hospital at the College of Veterinary Medicine and Animal Science of University of São Paulo, in a 10 year period. The retrospective study was performed through the analysis of documented cases. The sampling included the totality of equide cases with confirmed joint disease diagnosis and analyzed considering: age, sex, breed, sportive activity, beginning and evolution of the disease, clinical signs observed and radiographic exam. One hundred and fifty two (152) equides hospital forms with confirmed osteoarthritis were analyzed .It was found that most cases were equines, with an average age of 8 years, either male or female, with the predominance of Quarter Horses, Mangalarga Paulista and Mixed Breds, weighing around 420Kg, used for long distance rides or western activities. The average time between the beginning of the osteoarthritis clinical signs and the referring to the hospital was 7,7 months. The statistical analysis did not show relation between lameness, palpable pain, hoof sensitivity, muscular pain, positive flexion test and use (p>0,05). Although, its howed a relation between edema /heat and use (p<0,05). No relation was found between palpable pain, edema/heat, hoof and muscular pain and lameness (p<0,05). The results found in the radiographic evaluation of the animals with osteoarthritis showed no direct relation between the radiographic score and lameness. The animals with osteoarthritis more frequently sent to the Equine Internal Medicine Service -HOVET-USP, is equine , Quarter Horse, 8 years old, 420Kg, used in western competitions.
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Mukisi, Mukaza Martin. "Contribution à l'étude de l'ostéonécrose drépanocytaire de la tête fémorale de l'adulte: épidémiologie, diagnostic et traitement." Doctoral thesis, Universite Libre de Bruxelles, 2010. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210075.

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La drépanocytose est la maladie moléculaire et héréditaire (transmission mendélienne récessive et autosomique) la plus répandue au monde. Elle est un problème de santé publique par sa gravité et ses implications socio-économiques dans de nombreux pays. Seuls les sujets homozygotes (SS) ou hétérozygotes composites (SC) sont malades, les hétérozygotes (AS) ne sont que des transmetteurs du gène S. Elle est la première cause d’OstéoNécrose de la Tête Fémorale (ONTF), douloureuse évoluant vers l’arthrose, en l’absence de traitement chez un patient jeune.

La Guadeloupe compte 450.000 habitants, dont 12% sont porteurs de l’hémoglobine S. Le nombre des drépanocytaires est estimé à 1.200 dont les 3/4 sont suivis au Centre Caribéen de la Drépanocytose (CCD), créé en 1990. Le centre assure la prise en charge médicale des enfants dès leur naissance et des adultes malades. Nos activités au CHU de Pointe-à-Pitre, au CCD et à l’Unité INSERM-UMR S458 depuis juillet 1992 nous ont permis d’étudier:

- le diagnostic de l’ONTF;

- l’évaluation de l’hyperpression osseuse dans l’ONTF et l’évaluation du traitement par forage simple;

- l’étude de l’impact de la prise en charge orthopédique précoce sur la survenue et l’évolution de l’ONTF.

Notre étude concerne les patients drépanocytaires adultes homozygotes (SS) et double hétérozygotes (SC):

- une série rétrospective de 1993-1994 [E-1994] portant sur 115 patients (58 SS, 57 SC) identifiés en 1984,

sans suivi médical ni orthopédique;

- une série prospective de 1995 à 2008 [E-2008] portant sur 215 patients (94 SS, 121 SC) avec prise en

charge médicale et orthopédique.

L’IRM est l’examen de référence pour le diagnostic de l’ONTF comme dans la nécrose idiopathique. En absence d’imagerie moderne, la radiographie traditionnelle réalisée de façon complète (profil et, surtout, faux profil), permet le diagnostic avant toute déformation. Seules les lésions cliniquement symptomatiques et évolutives (examen clinique itératif, contrôle radiologique, tomographie, TDM ou IRM) ont une indication opératoire.

L’hyperpression intra osseuse, dans l’ONTF drépanocytaire, est significativement liée à la douleur (que les patients soient homozygotes ou hétérozygotes). Sa diminution a un effet antalgique objectif, observée après forage. Elle permet de confirmer le diagnostic d’ostéonécrose au stade précoce, dans les régions où l’IRM est inexistante.

Un forage réalisé aux stades précoces de l’ONTF permet un arrêt rapide de l’évolution des lésions vers une arthrose, avec une efficacité certaine pour les stades I et II. Il garde une efficacité limitée pour le stade III. En plus de l’indolence apportée par la décompression, le bénéfice du forage se manifeste par l’allongement du délai avant arthroplastie (de 7,4 ± 2,7 ans). La technique est réalisable dans les régions sous équipées, où la drépanocytose est fréquente.

La description histologique aux différents stades radiologiques de l’ONTF montre toujours des lésions de nécrose médullaire et osseuse. A l’inverse des lésions idiopathiques, les lésions drépanocytaires sont caractérisées par la présence d’une inflammation, en dehors de tout processus infectieux.

Dans la littérature, la fréquente de l’ONTF drépanocytaire chez l’adulte est voisine de 40%, proche de celle observée dans [E-1994], notre population non suivie (36,5%). En comparant les études [E-1994] et [E-2008], la fréquence de l’ONTF passe de 36,5% à 14,4%. L’officialisation en 1992 d’une prise en charge médicale et d’un suivi orthopédique régulier au CCD et au CHU de Pointe-à-Pitre, a permis la réduction de la fréquence de l’ONTF et d’autres morbidités.

Le rappel sur la drépanocytose révèle la complexité de la maladie, la variabilité de son expression clinique et de ses complications. L’amélioration de vie des patients nécessite une prévention primaire, secondaire et tertiaire, en l’absence d’un traitement spécifique de la maladie.

La prise en charge médicale, complétée par une prévention et un traitement précoce (orthopédique ou chirurgical) telle que réalisés au CCD en Guadeloupe, a permis une réduction significative de la survenue de la nécrose de hanche et de ses complications. Pour une prévention tertiaire des complications ostéo-articulaires, nous suggérons:

- une prise en charge médicale régulière des enfants et des adultes afin de réduire les crises vaso-occlusives;

- une éducation des patients à la recherche de signes d’appel de l'ONTF et, aussi, d’autres articulations;

- un examen clinique ostéo-articulaire lors des bilans annuels et après toute crise vaso-occlusive;

- une attention particulière à l’adolescence (passage enfant-adulte), après une grossesse;

- une prise en charge précoce, orthopédique ou chirurgicale conservatrice (forage ou ostéotomie) face à une

nécrose, afin de réduire les complications invalidantes de l’ONTF.

Sickle-cell anemia is the most widespread hereditary (autosomal recessive Mendelian transmission) molecular pathology in the world. It is a public health issue in many countries, due to its severity and socio-economic impact. Only homozygous (SS) and double heterozygous (SC) subjects are affected, heterozygous (AS) subjects merely transmitting the gene S. Sickle-cell anemia is the most frequent cause of osteonecrosis of the femoral head (ONFH), a painful condition which evolves towards osteoarthritis if not treated at an early age.

Guadeloupe has a population of 450,000, 12% of whom are carriers of hemoglobin S. There are estimated to be 1,200 sickle-cell anemia sufferers, three-quarters of whom are followed in the Caribbean Sickle-Cell Center (Centre Caribéen de la Drépanocytose: CCD), which was set up in 1990. The Center provides medical care for adult patients and for children as of birth. Work has been ongoing since July 1992, in the Pointe-à-Pitre University Hospital, the CCD and the INSERM-UMR S458 research unit, focusing on:

- diagnosis of ONFH;

- bone hyperpressure measurement in ONFH and assessment of simple drilling treatment;

- the impact of early orthopedic treatment on the onset and evolution of ONFH.

The present study involved homozygous (SS) and double heterozygous (SC) adult sickle-cell anemia patients:

- a retrospective series, from 1993 to 1994 [S-1994], including 115 patients (58 SS, 57 SC) identified in 1984,

who had no medical or orthopedic care;

- a prospective series, from 1995 to 2008 [S-2008], including 215 patients (94 SS, 121 SC), with medical and orthopedic care.

MRI is the diagnostic gold-standard in ONFH, as in idiopathic necrosis. Where such modern imaging is not available, complete standard X-ray (lateral and especially false lateral) enables diagnosis to be made before deformity sets in. Surgery is indicated only for clinically symptomatic evolutive lesions on iterative clinical check-up, X-ray control, tomography, CT or MRI.

Intraosseous hyperpressure in sickle-cell ONFH shows a significant correlation with pain, in both homozygous and heterozygous patients. Pressure reduction is objectively pain-relieving, as seen after drilling, and can confirm diagnosis of ONFH at an early stage, in places where MRI is not available.

Drilling performed in the early stages of ONFH quickly arrests evolution towards osteoarthritis, with proven efficacy in grades I and II, and a certain degree of effectiveness in grade III. Over and above the pain-relief provided by decompression, drilling also enables hip replacement to be postponed, by 7.4±2.7 years. Moreover, the technique is feasible in those under-equipped regions in which sickle-cell disease is widespread.

Histologic description of radiologic ONFH stages consistently finds medullary and bone necrosis. In contrast to idiopathic lesions, sickle-cell related lesions show inflammation without any associated infection.

In the literature, the frequency of adult sickle-cell ONFH is reported to be nearly 40%, close to the 36.5% found in the S-1994 study of a non-treated population. In the S-2008 study of a population with medical and orthopedic care, ONFH frequency fell to 14.4%. The official provision of medical care and regular orthopedic follow-up in the CCD and Pointe-à-Pitre Hospital has reduced the frequency of ONFH and other morbidities.

A review of sickle-cell disease reveals its complexity: the variability of its clinical expression and associated complications. Improving patients’ quality of life requires primary, secondary and tertiary prevention, in the absence of specific treatment.

Medical care, supplemented by early prevention and treatment (orthopedic or surgical), as practiced in the Guadeloupe CCD, has significantly reduced the rates of ONFH and associated complications. We recommend the following CCD protocol for tertiary prevention of osteoarticular complications:

- regular medical care for children and adults, to reduce the incidence of vaso-occlusive crises;

- patient education in alarm signs of osteonecrosis of the femoral head and of other joints;

- systematic osteoarticular assessment at yearly check-up and after all vaso-occlusive crises;

- special focus on adolescence (child-to-adult transition) and following pregnancy;

- early care, both orthopedic and by conservative surgery (drilling or osteotomy), in case of necrosis, to reduce the rate of disabling complications of ONFH
Doctorat en Sciences médicales
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Books on the topic "JOINT DISEASES; DIAGNOSIS"

1

Diagnosis of bone and joint disorders. 3rd ed. Philadelphia: Saunders, 1995.

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Joseph, Weisberg, ed. Temporomandibular joint disorders: Diagnosis and treatment. Chicago: Quintessence Pub. Co., 1985.

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Ai, Minoru. Temporomandibular dysfunction: Diagnosis and treatment. St. Louis: Ishiyaku EuroAmerica, 1993.

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Per-Lennart, Westesson, ed. Diagnosis of the temporomandibular joint. Philadelphia: W. B. Saunders Co., 1993.

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Pak, Yong-hwi. Combined scintigraphic and radiographic diagnosis of bone and joint diseases. 2nd ed. Berlin: Springer, 2000.

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Pak, Yong-hwi. Combined scintigraphic and radiographic diagnosis of bone and joint diseases. 3rd ed. Berlin: Springer, 2007.

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Combined scintigraphic and radiographic diagnosis of bone and joint diseases. Berlin: Springer-Verlag, 1992.

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Burgener, Francis A. Bone and joint disorders: Conventional radiologic differential diagnosis. Stuttgart: G. Thieme Verlag, 1997.

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Goldman, A. Richard. TMJ syndrome: The overlooked diagnosis. New York: Congdon & Weed, 1987.

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Virginia, McCullough, ed. TMJ syndrome: The overlooked diagnosis. New York: Simon & Schuster, 1989.

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Book chapters on the topic "JOINT DISEASES; DIAGNOSIS"

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Bahk, Yong-Whee. "Degenerative Joint Diseases." In Combined Scintigraphic and Radiographic Diagnosis of Bone and Joint Diseases, 155–99. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-2759-8_9.

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Bahk, Yong-Whee. "Degenerative Joint Diseases." In Combined Scintigraphic and Radiographic Diagnosis of Bone and Joint Diseases, 141–83. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-25144-3_9.

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Bahk, Yong Whee. "Degenerative Joint Diseases." In Combined Scintigraphic and Radiographic Diagnosis of Bone and Joint Diseases, 73–97. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-662-06294-4_7.

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Bahk, Yong-Whee. "Degenerative Joint Diseases." In Combined Scintigraphic and Radiographic Diagnosis of Bone and Joint Diseases, 81–105. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-662-04106-2_7.

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Stegenga, Boudewijn. "Temporomandibular joint degenerative diseases: clinical diagnosis." In Management of Temporomandibular Joint Degenerative Diseases, 13–25. Basel: Birkhäuser Basel, 1996. http://dx.doi.org/10.1007/978-3-0348-8992-6_2.

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Abdulkhaliq, Altaf, and Manal Alotaibi. "Laboratory Interpretation of Rheumatic Diseases." In Skills in Rheumatology, 67–81. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-8323-0_3.

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AbstractGenerally the diagnosis of rheumatic diseases is based on a set of clinical, serological, and radiological measures. The discovery of a novel test that appears to be considerably more disease-specific and preferably sensitive would be of value for the early diagnosis and immediate, effective therapy to prevent joint deterioration, functional disability, and unfavorable disease outcome [1].
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Boyce, Brendan F. "Pathology of Metabolic Bone and Joint Diseases." In Histology of Ancient Human Bone: Methods and Diagnosis, 171–84. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77001-2_11.

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Bahk, Yong Whee. "Metabolic Bone Diseases." In Combined Scintigraphic and Radiographic Diagnosis of Bone and Joint Diseases, 163–68. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-662-06294-4_13.

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Bahk, Yong Whee. "Otorhinological Bone Diseases." In Combined Scintigraphic and Radiographic Diagnosis of Bone and Joint Diseases, 219–26. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-662-06294-4_16.

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Bahk, Yong-Whee. "Metabolic Bone Diseases." In Combined Scintigraphic and Radiographic Diagnosis of Bone and Joint Diseases, 189–95. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-662-04106-2_13.

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Conference papers on the topic "JOINT DISEASES; DIAGNOSIS"

1

Krishnan, G. Hari, R. Ananda Natarajan, and Anima Nanda. "Microcontroller based non invasive diagnosis of knee joint diseases." In 2014 International Conference on Information Communication and Embedded Systems (ICICES). IEEE, 2014. http://dx.doi.org/10.1109/icices.2014.7034178.

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Reddy, Mandal, and Rothschild. "Accelerometer Measurements For Noninvasive Diagnosis Of Degenerative Joint Diseases." In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 1992. http://dx.doi.org/10.1109/iembs.1992.589293.

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Reddy, Narender P., Mita Mandal, and Bruce M. Rothschild. "Accelerometer measurements for noninvasive diagnosis of degenerative joint diseases." In 1992 14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 1992. http://dx.doi.org/10.1109/iembs.1992.5760842.

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Zheng, Kai, Gangquan Si, and Chen Duan. "Diagnosis of kashin-beck disease and other common joint diseases via a gene model." In 2017 IEEE 2nd Information Technology, Networking, Electronic and Automation Control Conference (ITNEC). IEEE, 2017. http://dx.doi.org/10.1109/itnec.2017.8284846.

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Yin, Kejing, William K. Cheung, Yang Liu, Benjamin C. M. Fung, and Jonathan Poon. "Joint Learning of Phenotypes and Diagnosis-Medication Correspondence via Hidden Interaction Tensor Factorization." In Twenty-Seventh International Joint Conference on Artificial Intelligence {IJCAI-18}. California: International Joint Conferences on Artificial Intelligence Organization, 2018. http://dx.doi.org/10.24963/ijcai.2018/504.

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Non-negative tensor factorization has been shown effective for discovering phenotypes from the EHR data with minimal human supervision. In most cases, an interaction tensor of the elements in the EHR (e.g., diagnoses and medications) has to be first established before the factorization can be applied. Such correspondence information however is often missing. While different heuristics can be used to estimate the missing correspondence, any errors introduced will in turn cause inaccuracy for the subsequent phenotype discovery task. This is especially true for patients with multiple diseases diagnosed (e.g., under critical care). To alleviate this limitation, we propose the hidden interaction tensor factorization (HITF) where the diagnosis-medication correspondence and the underlying phenotypes are inferred simultaneously. We formulate it under a Poisson non-negative tensor factorization framework and learn the HITF model via maximum likelihood estimation. For performance evaluation, we applied HITF to the MIMIC III dataset. Our empirical results show that both the phenotypes and the correspondence inferred are clinically meaningful. In addition, the inferred HITF model outperforms a number of state-of-the-art methods for mortality prediction.
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Wang, Zengmao, Bo Du, Lefei Zhang, Liangpei Zhang, Ruimin Hu, and Dacheng Tao. "On Gleaning Knowledge from Multiple Domains for Active Learning." In Twenty-Sixth International Joint Conference on Artificial Intelligence. California: International Joint Conferences on Artificial Intelligence Organization, 2017. http://dx.doi.org/10.24963/ijcai.2017/420.

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How can a doctor diagnose new diseases with little historical knowledge, which are emerging over time? Active learning is a promising way to address the problem by querying the most informative samples. Since the diagnosed cases for new disease are very limited, gleaning knowledge from other domains (classical prescriptions) to prevent the bias of active leaning would be vital for accurate diagnosis. In this paper, a framework that attempts to glean knowledge from multiple domains for active learning by querying the most uncertain and representative samples from the target domain and calculating the importance weights for re-weighting the source data in a single unified formulation is proposed. The weights are optimized by both a supervised classifier and distribution matching between the source domain and target domain with maximum mean discrepancy. Besides, a multiple domains active learning method is designed based on the proposed framework as an example. The proposed method is verified with newsgroups and handwritten digits data recognition tasks, where it outperforms the state-of-the-art methods.
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Zhao, Stan, Meng Jiang, Quan Yuan, Bing Qin, Ting Liu, and ChengXiang Zhai. "ContextCare: Incorporating Contextual Information Networks to Representation Learning on Medical Forum Data." In Twenty-Sixth International Joint Conference on Artificial Intelligence. California: International Joint Conferences on Artificial Intelligence Organization, 2017. http://dx.doi.org/10.24963/ijcai.2017/489.

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Online users have generated a large amount of health-related data on medical forums and search engines. However, exploiting these rich data for orienting patient online and assisting medical checkup offline is nontrivial due to the sparseness of existing symptom-disease links, which caused by the natural and chatty expressions of symptoms. In this paper, we propose a novel and general representation learning method ContextCare for human generated health-related data, which learns the latent relationship between symptoms and diseases from the symptom-disease diagnosis network for disease prediction, disease category prediction and disease clustering. To alleviate the network sparseness, ContextCare adopts regularizations from rich contextual information networks including a symptom co-occurrence network and a disease evolution network. Therefore, our representations of symptoms and diseases incorporate knowledge from these three networks. Extensive experiments on medical forum data demonstrate that ContextCare outperforms the state-of-the-art methods in disease category prediction, disease prediction and disease clustering.
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Ritzi-Lehnert, Marion. "Entering a New Era of Diagnosis." In ASME 2010 8th International Conference on Nanochannels, Microchannels, and Minichannels collocated with 3rd Joint US-European Fluids Engineering Summer Meeting. ASMEDC, 2010. http://dx.doi.org/10.1115/fedsm-icnmm2010-30174.

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Looking at the development of diagnostics from prehistorical days up to know and even further visioning into the future the shamans of the old days were slowly replaced by the early “all-round” doctor having first simple diagnostical and surgery possibilities, changing to nowadays specialized physicians doing the diagnoses based on analytical results provided by decentralized specialized labs. Future visions present doctors offices harboring small instruments that allow the physicians to do analyses directly as fast and as minimally or even non-invasive as possible advantageously combined with a connection to a smart health care database providing anamnesis and providing possible therapeutical measures. Already in the 1960s’ science fiction series Star Trek the spaceship crew used very small instruments for fast, non-invasive diagnosis and treatment. Although, such analyzers are future vision actual developments lead to less and less complex and small systems. Using micro- and nano-technologies manifold approaches addressing so-called “Lab-on-a-chip (LoC)” or “micro total analysis systems (μTAS)” where described during the last two decades. Huge progress can be seen in miniaturization not only of electronics but also of mechanics. While presently, table-top systems reach the market handheld systems providing complete analysis from sample taking to result are rare. Presently, often complex sample preparation methods have to be performed to reach the sensitivity and robustness needed for reliable results. In addition, specific disease markers are still missing that give clear conclusions about health status. In this field, intensive research is going on identifying new better and more specific markers for fast and easy reliable determination of diseases, infections, predispositions and more. Having markers available where each marker gives a non-misleading conclusion that a person will have or already has a certain disease, being able to determine these markers directly from the sample without complex sample preparation steps and having instruments available being preferably portable and applicable by non-specialists such a vision is getting closer. The actually developed miniaturized instruments are an important step towards the envisioned future systems demonstrating the basic proof of concept and thereby heralding a new era of diagnosis.
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Zheng, Kai, Gangquan Si, and Chen Duan. "Application of a gene diagnosis model in the identification of Kashin-Beck disease and similar joint diseases." In 2017 3rd IEEE International Conference on Computer and Communications (ICCC). IEEE, 2017. http://dx.doi.org/10.1109/compcomm.2017.8323018.

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Jakobsen, SH, A. Emamifar, and IMJ Hansen. "AB1239-HPR Fatigue at diagnosis of inflammatory joint diseases - a predictor of fatigue during the course of disease despite of low disease activity." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.1885.

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Reports on the topic "JOINT DISEASES; DIAGNOSIS"

1

Swaby, James A., James C. McAvin, and Ratree Takhampunya. Test and Evaluation of Field-Deployable Infectious Disease Diagnostic Assays in Support of the Joint Biological Agent Identification and Diagnosis System (JBAIDS): Malaria (Plasmodium/JBAIDS). Fort Belvoir, VA: Defense Technical Information Center, May 2012. http://dx.doi.org/10.21236/ada562427.

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