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1

Kahn, C. Ronald, and Julie Fitzpatrick Rafferty. "The Joslin Diabetes Center." Molecular Medicine 6, no. 2 (2000): 65–68. http://dx.doi.org/10.1007/bf03401774.

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2

Mehta, Sanjeev N., Henrik Ullits Andersen, Martin J. Abrahamson, et al. "Changes in HbA1c and Weight Following Transition to Continuous Subcutaneous Insulin Infusion Therapy in Adults With Type 1 Diabetes." Journal of Diabetes Science and Technology 11, no. 1 (2016): 83–86. http://dx.doi.org/10.1177/1932296816658900.

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Background: Historically, intensive insulin therapy for type 1 diabetes (T1D) has improved glycemic control at the risk of adverse weight gain. The impact of continuous subcutaneous insulin infusion therapy (CSII) on weight in the current era remains unknown. We assessed changes in hemoglobin A1c (HbA1c) and weight in adults with T1D transitioning to CSII at 2 diabetes centers in Denmark and the United States. Methods: Patients with T1D, aged ≥18 years, managed with multiple daily injections (MDI) who transitioned to CSII between 2002 and 2013 were identified using electronic health record dat
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3

Owens, Brian. "Profile: Joslin Diabetes Center, Boston, MA, USA." Lancet 386, no. 9997 (2015): 944. http://dx.doi.org/10.1016/s0140-6736(15)00116-6.

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4

Owens, Brian. "George King: research leader at the Joslin Diabetes Center." Lancet 386, no. 9997 (2015): 947. http://dx.doi.org/10.1016/s0140-6736(15)00110-5.

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5

Giusti, Judy, and Jo-Anne Rizzotto. "Interpreting the Joslin diabetes center and joslin clinic clinical nutrition guideline for overweight and obese adults with type 2 diabetes." Current Diabetes Reports 6, no. 5 (2006): 405–8. http://dx.doi.org/10.1007/s11892-006-0014-y.

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6

Rahmatia, Sitti, Mardiana Mustafa, and Andy Setiawan. "PENGARUH SELF DIABETES MANAGEMENT EDUCATION (SDME) TERHADAP PENGETAHUAN ANGGOTA KELUARGA PENDERITA DIABETES MELITUS DI WILAYAH KERJA PUSKESMAS MANGASA KOTA MAKASSAR." Media Keperawatan: Politeknik Kesehatan Makassar 10, no. 2 (2019): 115. http://dx.doi.org/10.32382/jmk.v10i2.1308.

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ABSTRACTSelf Diabetes Management Education (SDME) is a process of health education for individuals or families in managing Diabetes Melitus which has been developed since the 1930s by Joslin Diabetes Center. SDME uses guideline, counseling and intervention methods to increase knowledge about Diabetes Mellitus and improve individual and family skills in managing Diabetes Mellitus. Lack of knowledge or public awareness is one of the factors that contribute to the high incidence of diabetes mellitus. In general, the purpose of the research was to determine the effect of SDME on the knowledge of f
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7

Seley, Jane Jeffrie, and Katie Weinger. "The State of the Science on Nursing Best Practices for Diabetes Self-Management." Diabetes Educator 33, no. 4 (2007): 616–26. http://dx.doi.org/10.1177/0145721707305121.

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Jane Jeffrie Seley is a diabetes nurse practitioner at New York Presbyterian—Weill Cornell Medical Center, New York City. She is a contributing editor and the column coordinator for Diabetes Under Control in the American Journal of Nursing. Katie Weinger is an investigator in behavioral and mental health research, director of the Center of Innovation in Diabetes Education and of the Office of Research Fellow Affairs at Joslin Diabetes Center, and an assistant professor of psychiatry at Harvard Medical School, all in Boston. She has received a grant from the National Institutes of Health (NIDDK
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8

Fickweiler, Ward, Tanvi Chokshi, Surya Jangolla, et al. "CLINICAL CHARACTERIZATION OF AQUEOUS AND VITREOUS RETINOL-BINDING PROTEIN 3 CONCENTRATIONS IN RELATION TO DIABETIC RETINOPATHY SEVERITY, RETINAL STRUCTURES, AND SYSTEMIC COMPLICATIONS." Retina 44, no. 6 (2024): 1026–33. http://dx.doi.org/10.1097/iae.0000000000004059.

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Purpose: To evaluate Retinol-Binding Protein 3 (RBP3) from photoreceptors in aqueous and its association with vitreous concentrations, diabetic retinopathy (DR) severity, retinal layer thickness, and clinical characteristics in people with diabetes. Methods: RBP3 concentration was measured by custom-developed enzyme-linked immunosorbent assay in aqueous and correlated with vitreous concentrations in patients from the 50-Year Medalist study and Beetham Eye Institute at Joslin Diabetes Center. Results: Aqueous RBP3 concentration (N = 131) was elevated in eyes with no to mild DR (mean ± SD 0.7 nM
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9

Kahn, C. Ronald. "C. Ronald Kahn, MD, of Joslin Diabetes Center and Harvard Medical School Wins Bristol-Myers Squibb Metabolic Research Award." Journal of Investigative Medicine 52, no. 6 (2004): 354. http://dx.doi.org/10.1177/108155890405200617.

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10

Brown, C. "Enhancing Electronic Medical Records to Support National Standards for Diabetes Self-Management Education: A Case Study at the Joslin Diabetes Center Affiliate at the University of Maryland Medical Center." Journal of the American Dietetic Association 110, no. 9 (2010): A21. http://dx.doi.org/10.1016/j.jada.2010.06.074.

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11

Figueroa, Ariel E., Neil Roy, Andreina Millan-Ferro, Paolo S. Silva, and Sylvia E. Rosas. "Association of Diabetic Retinopathy with Chronic Kidney Disease Progression in Latinos with Type 2 Diabetes." Ethnicity and Disease 33, no. 1 (2023): 9–16. http://dx.doi.org/10.18865/1683.

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Aims Diabetes remains a leading cause of blindness and kidney failure in the United States. Latinos are at increased risk for type 2 diabetes, and microvascular complications such as diabetic retinopathy (DR) and chronic kidney disease (CKD). We evaluated the association of DR with decline in kidney function in Latinos with type 2 diabetes with or without CKD in a multispecialty clinic. Methods This is a retrospective cohort study of 351 self-identified Latino individuals with type 2 diabetes enrolled in the Latino Diabetes Initiative at Joslin Diabetes Center. Baseline demographic factors inc
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12

Amiel, Stephanie A., Pratik Choudhary, Peter Jacob, et al. "Hypoglycaemia Awareness Restoration Programme for People with Type 1 Diabetes and Problematic Hypoglycaemia Persisting Despite Optimised Self-care (HARPdoc): protocol for a group randomised controlled trial of a novel intervention addressing cognitions." BMJ Open 9, no. 6 (2019): e030356. http://dx.doi.org/10.1136/bmjopen-2019-030356.

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IntroductionSevere hypoglycaemia (SH), when blood glucose falls too low to support brain function, is the most feared acute complication of insulin therapy for type 1 diabetes mellitus (T1DM). 10% of people with T1DM contribute nearly 70% of all episodes, with impaired awareness of hypoglycaemia (IAH) a major risk factor. People with IAH may be refractory to conventional approaches to reduce SH, with evidence for cognitive barriers to hypoglycaemia avoidance. This paper describes the protocol for the Hypoglycaemia Awareness Restoration Programme for People with Type 1 Diabetes and Problematic
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13

Kearns, JoAnn W., Karen Kemmis, Robert Ploutz-Snyder, and Ruth S. Weinstock. "Initiating Treatment Success — My Individualized Nutrition and Exercise Plan." Diabetes Educator 31, no. 2 (2005): 199–205. http://dx.doi.org/10.1177/0145721705275453.

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The authors’ class structure incorporates individual meal and exercise planning in the group setting. This study was conducted to (1) determine if class participants can create their own meal and exercise plans, (2) determine if class participants feel they will be able to adhere to their meal and exercise plans, and (3) assess adherence to the plans over time. Subjects were recruited from the classes offered at the Joslin Diabetes Center. Following completion of class, patients completed the evaluation questionnaire. Two and 6 months later, study participants received follow-up questionnaires
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Quintana, Yuri, David Einstein, Robin Joyce, et al. "Accelerating Learning Health Systems Using Alicanto Collaboration Platforms." JCO Global Oncology 8, Supplement_1 (2022): 62. http://dx.doi.org/10.1200/go.22.68000.

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PURPOSE Global health challenges require systematic approaches that bring together a wide range of stakeholders and experts unevenly distributed worldwide. We saw an even greater need to find novel ways to collaborate during the pandemic due to limited in-person meetings and travel restrictions. The purpose of this project is to accelerate collaborations in learning health systems with online technologies to improve communication, education, and knowledge management. METHODS We developed Alicanto Cloud, an online collaboration platform for healthcare professionals to support learning health sy
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15

Casper, Katie. "The Effect of Acute Discontinuation of Total Parenteral Nutrition L.D. WAGMAN, K.B. MILLER, R.B. THOMAS, H.H. NEWSOME, AND G.C. WEIR Department of General Oncologic Surgery, City of Hope National Medical Center, Duarte, California; Department of Surgery, Medical College of Virginia, Richmond, Virginia; and Joslin Diabetes Center, Joslin Clinic, Boston, Massachusetts." Nutrition in Clinical Practice 2, no. 5 (1987): 215. http://dx.doi.org/10.1177/088453368700200508.

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16

Dhaver, Shilton, Marwa Al Badri, Shaheen Tomah, et al. "Hybrid Model of Intensive Lifestyle Intervention for Patients with Diabetes & Obesity for Post-COVID Era." Current Developments in Nutrition 6, Supplement_1 (2022): 1058. http://dx.doi.org/10.1093/cdn/nzac070.017.

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Abstract Objectives The Weight Achievement and Intensive Treatment (Why WAIT) program is a 12-week multidisciplinary intensive lifestyle intervention (ILI) program for diabetes and weight management. We previously showed that the in-person model (iPM) of ILI has led to long-term maintenance of 6.9% weight loss for up to 10 yrs in real-world clinical practice. With the advent of the COVID-19 pandemic, we reported that a totally virtual model (VM) of the ILI program for the same duration was equally effective in reducing body weight and improving glycemic control. In this study, we test a newly
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17

Zheng, Yaguang, Katie Weinger, Jordan Greenberg, et al. "Actual Use of Multiple Health Monitors Among Older Adults With Diabetes: Pilot Study." JMIR Aging 3, no. 1 (2020): e15995. http://dx.doi.org/10.2196/15995.

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Background Previous studies have reported older adults’ perceptions of using health monitors; however, no studies have examined the actual use of multiple health monitors for lifestyle changes over time among older adults with type 2 diabetes (T2D). Objective The primary aim of this study was to examine the actual use of multiple health monitors for lifestyle changes over 3 months among older adults with T2D. The secondary aim was to explore changes in caloric intake and physical activity (PA) over 3 months. Methods This was a single-group study lasting 3 months. The study sample included part
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18

Wang, Olivia H., Miranda Zuniga-Kennedy, Luciana Mascarenhas Fonseca, et al. "4 Associations Between Glycemia and Cognitive Performance in Adults with Type 1 Diabetes (T1D) using Continuous Glucose Monitoring (CGM) and Ecological Momentary Assessment (EMA)." Journal of the International Neuropsychological Society 29, s1 (2023): 792–93. http://dx.doi.org/10.1017/s1355617723009840.

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Objective:Despite associations between hypoglycemia and cognitive performance using cross-sectional and experimental methods (e.g., Insulin clamp studies), few studies have evaluated this relationship in a naturalistic setting. This pilot study utilizes an EMA study design in adults with T1D to examine the impact of hypoglycemia and hyperglycemia, measured using CGM, on cognitive performance, measured via ambulatory assessment.Participants and Methods:Twenty adults with T1D (mean age 38.9 years, range 26-67; 55% female; 55% bachelor’s degree or higher; mean HbA1c = 8.3%, range 5.4% - 12.5%), w
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"INSIDE INDUSTRY." Asia-Pacific Biotech News 17, no. 10n11 (2013): 49–58. http://dx.doi.org/10.1142/s0219030313000748.

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Singapore and Korea research institutes to collaborate on biomass-to-chemicals research. Nobel prize in medicine goes to cell transport discovery. Tri-institutional Therapeutics Discovery Institute, Inc. launched. Agilent Technologies collaborates with Florey Institute of Neuroscience and Mental Health. Quintiles selected by Muscular Dystrophy Association to develop U.S. Disease Registry. Joslin Diabetes Center forms alliance with John & Johnson Innovation to identify exercise-related drug targets to improve diabetes management. CLINATEC chairman Alim-Louis Benabid honored for Parkinson's
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PICKETT, SARA, SALINA MOON, GEORGIOS THEOCHARIDIS, ZAIPUL MD DOM, MONIKA NIEWCZAS, and ARISTIDIS VEVES. "507-P: Trajectories of Inflammatory Proteins over Diabetic Wound Healing Course." Diabetes 72, Supplement_1 (2023). http://dx.doi.org/10.2337/db23-507-p.

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Background: Inflammatory processes are dynamic over the Diabetic Foot Ulceration (DFU) course. We aimed to evaluate longitudinal trajectories of circulating biomarkers in subjects with DFU. Methods: The study cohort comprised 39 subjects with DFU from the Joslin-Beth Israel Deaconess Foot Center. During the 12 weeks of follow-up (6 bi-weekly visits), 15 subjects (38%) had their DFU healed (healers). Twenty-eight proteins were measured at each visit on the Luminex platform. Results: Circulating IL-10 levels at baseline were significantly higher in DFU healers in comparison with non-healers (OR:
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21

FICKWEILER, WARD, SURYA VISHVA TEJA JANGOLLA, TANVI CHOKSHI, et al. "110-OR: Association of Glycemic Control with Inverse Risk of Age-Related Macular Degeneration and Diabetic Retinopathy Severity in Type 1 Diabetes." Diabetes 74, Supplement_1 (2025). https://doi.org/10.2337/db25-110-or.

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Introduction and Objective: To determine association of metabolic control with the presence of age-related macular degeneration (AMD) and diabetic retinopathy (DR) severity in patients with type 1 diabetes (T1D). Methods: Retinal images were examined for the presence of AMD (AREDS classification) and DR severity (ETDRS scale) in individuals with T1D from the Beetham Eye Institute (BEI, N=1413) and in an age-comparable group with T1D duration for over 50yrs (Joslin Medalists Study, N=1019) at Joslin Diabetes Center. Proteomic profiling of retinal tissue from a subset of Medalists (N=20) was per
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22

ElSayed, Nuha A., Grazia Aleppo, Vanita R. Aroda, et al. "Addendum. 2. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes—2023. Diabetes Care 2023;46(Suppl. 1):S19–S40." Diabetes Care, June 25, 2023. http://dx.doi.org/10.2337/dc23-ad08.

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Section 2, “Classification and Diagnosis of Diabetes,” of the Standards of Care in Diabetes—2023 has been updated to refine the diagnostic criteria for type 1 diabetes based on recent U.S. Food and Drug Administration approval of a new drug to delay the incidence of type 1 diabetes. The online version of the article (https://doi.org/10.2337/dc23-S002) reflects the changes described below. Jason L. Gaglia, of Joslin Diabetes Center and Harvard Medical School, Boston, MA, has been added as an author due to his expertise in immunology and type 1 diabetes. The author list and disclosures table (p.
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23

"C. Ronald Kahn, MD, of Joslin Diabetes Center and Harvard Medical School Wins Bristol-Myers Squibb Metabolic Research Award." Journal of Investigative Medicine 52, no. 6 (2004): 354. http://dx.doi.org/10.1097/00042871-200409000-00017.

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24

"C. Ronald Kahn, MD, of Joslin Diabetes Center and Harvard Medical School Wins Bristol-Myers Squibb Metabolic Research Award." Journal of Investigative Medicine 52, no. 6 (2004): 354. http://dx.doi.org/10.1136/jim-52-06-17.

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25

FICKWEILER, WARD, HYUNSEOK PARK, KYOUNGMIN PARK, et al. "42-OR: Association of Vitreous Retinol Binding Protein 3 with Inflammatory Cytokines and Progression of Diabetic Retinopathy in Type 1 and Type 2 Diabetes." Diabetes 71, Supplement_1 (2022). http://dx.doi.org/10.2337/db22-42-or.

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Although inflammatory cytokines and vascular endothelial growth factor (VEGF) have been proposed to underlie the progression of diabetic retinopathy (DR) , there remains an important need to identify biomarkers for early stages of DR. Findings from the Joslin Medalist Study, composed of individuals who have had insulin-dependent diabetes for 50 years or longer, showed that Retinol Binding Protein 3 (RBP3) was significantly higher both in retina and vitreous samples with no to mild DR compared to those with proliferative DR (PDR) . In this study, we examined vitreous and plasma samples from 2pe
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CHOKSHI, TANVI, WARD FICKWEILER, MARGALIT G. MITZNER, et al. "43-OR: Aqueous Retinol Binding Protein 3 Is Reduced in Patients with Advanced Diabetic Retinopathy in Type 1 and Type 2 Diabetes." Diabetes 71, Supplement_1 (2022). http://dx.doi.org/10.2337/db22-43-or.

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The Joslin Medalist Study identified Retinol-binding protein 3 (RBP3) as a potential protective factor against diabetic retinopathy (DR) in the vitreous and retina of individuals with type 1 diabetes for 50 years or longer. This study evaluated the association of aqueous RBP3 concentration to vitreous RBP3 concentrations and DR severity. We measured 131 aqueous samples from patients with type 1 and 2 diabetes undergoing cataract surgery at the Joslin Beetham Eye Institute (BEI) and postmortem samples of Medalists. Aqueous RBP3 concentrations in BEI and Medalists samples were similar for eyes w
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FICKWEILER, WARD, TANVI CHOKSHI, EMER O'DOHERTY, et al. "322-OR: Delaying Progression of Diabetic Retinopathy Worsens the Risk for Age-Related Macular Degeneration." Diabetes 73, Supplement_1 (2024). http://dx.doi.org/10.2337/db24-322-or.

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Given the increasing prevalence of diabetes in the elderly, understanding factors that influence age-related macular degeneration (AMD) and diabetic retinopathy (DR) is crucial to target intervention for both. Previously, we found an inverse relationship between DR and AMD in the Joslin 50-Year Medalist Study composed of individuals who have had insulin-dependent diabetes for over 50 years. This study evaluated the relationship between AMD and DR in an age-matched cohort of people with type 1 diabetes from the Beetham Eye Institute (BEI) at Joslin Diabetes Center (N=1413) with the Medalist Stu
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MIDDELBEEK, ROELAND, LAURA SIMPSON, GEORGIA A. HANSBURY, et al. "595-P: Exercise Training Improves Cardiorespiratory Parameters but Not VO2peak in People with Type 2 Diabetes." Diabetes 72, Supplement_1 (2023). http://dx.doi.org/10.2337/db23-595-p.

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Maximal oxygen consumption (VO2peak), a measure of cardiorespiratory fitness (CRF), is a strong predictor of mortality. People with type 2 diabetes (T2D) have lower VO2peak compared to healthy controls, and unfortunately, studies suggest that training has limited effects to improve VO2peak in T2D. Although VO2peak is a key component, additional respiratory functions may also be important markers of cardio-metabolic fitness. Here, we determined the effects of a 10-week moderate-intensity exercise training program on VO2peak, power (indicator of muscle strength), VO2/work (index of the body’s ef
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VAMVINI, MARIA, PASQUALE NIGRO, KRISTIN I. STANFORD, MICHAEL F. HIRSHMAN, ROELAND J. MIDDELBEEK, and LAURIE GOODYEAR. "1832-LB: Exercise Training and Cold Exposure Trigger Distinct Molecular Adaptations to Inguinal White Adipose Tissue." Diabetes 73, Supplement_1 (2024). http://dx.doi.org/10.2337/db24-1832-lb.

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Exercise training and cold exposure are physiological stimuli that both improve systemic glucose metabolism, but the mechanisms are not well understood. Here, we tested the hypothesis that adaptations to inguinal white adipose tissue (iWAT) are critical for the beneficial effects of exercise-trained and cold-exposed iWAT on metabolism. First, we utilized an iWAT transplantation model. Male donor mice were sedentary, exercise trained by voluntary wheel running, or cold exposed (5°C) for 11 days (n=5/group). Transplanting iWAT from exercised into sedentary mice enhanced glucose tolerance, yet co
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ADAM, ATIF, KA HEI KAREN LAU, HETAL SHAH, MARC GREGORY YU, and GEORGE L. KING. "943-P: Impact of Culturally Appropriate Diabetes Care amongst Asian Americans with Type 2 Diabetes during the COVID Pandemic." Diabetes 71, Supplement_1 (2022). http://dx.doi.org/10.2337/db22-943-p.

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Even as patients with T2D have been shown to have increased COVID-related morbidity and mortality, little is known on the impact of COVID on appointment adherence. This report reviews the impact of culturally-relevant diabetes clinics on adherence to clinical appointments, (pre-and during COVID) . This is a retrospective observational study using EMR data of adult patients with T2D managed at Joslin Diabetes Center before the COVID pandemic (April 20to Dec. 2019) and during the COVID pandemic (April 2020 to Dec. 2020) . Demographic and clinical visit data were extracted from patients seen at l
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31

Chokshi, Tanvi, Ward Fickweiler, Surya Jangolla, et al. "Reduced Aqueous Retinol-Binding Protein 3 Concentration Is Associated With Diabetic Macular Edema and Progression of Diabetic Retinopathy." Diabetes Care, November 20, 2024. http://dx.doi.org/10.2337/dc24-1260.

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OBJECTIVE To evaluate the association of aqueous retinol-binding protein 3 (RBP3) with history of diabetic macular edema (DME) and diabetic retinopathy (DR) progression. RESEARCH DESIGN AND METHODS RBP3 concentration was measured by ELISA in aqueous from patients undergoing cataract surgery at Joslin Diabetes Center. DR progression was defined as two-step or more worsening on the Early Treatment Diabetic Retinopathy Study severity scale, and DME history was determined by clinical diagnosis. RESULTS In 153 eyes (31 with type 1 and 122 with type 2 diabetes; n = 149 patients), 37% had no signs of
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KIBAA, KARIM, SHILTON E. DHAVER, COLLEEN JOHNSON, et al. "733-P: Diabetes Remission Outcomes Protocol (DROP)—Early Observation." Diabetes 72, Supplement_1 (2023). http://dx.doi.org/10.2337/db23-733-p.

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A 12-week multidisciplinary intensive lifestyle intervention (ILI) was shown to induce diabetes remission (A1C <6.5%, on no medications for ≥3 months), particularly among participants with short diabetes duration. Diabetes remission was also achieved with very low-calorie diet (VLCD) or bariatric surgery. Diabetes Remission Outcomes Protocol (DROP) at Joslin Diabetes Center is an ILI designed to induce diabetes remission in patients with type 2 diabetes who meet 3 criteria: 1- duration of diabetes <5 years, 2- A1C <8%, 3- On up to 2 antihyperglycemic medications, but no in
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"Reviews : Outsmarting Diabetes, by Richard S. Beaser and the staff at Joslin Diabetes Center (1994). Chronimed Publishing, 13911 Ridgedale Drive, Suite 250, Minneapolis, MN 55305. 240 pages. Price: $14.95." Diabetes Educator 21, no. 1 (1995): 85. http://dx.doi.org/10.1177/014572179502100119.

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VAMVINI, MARIA, PASQUALE NIGRO, LAURIE GOODYEAR, and ROELAND J. W. MIDDELBEEK. "579-P: Exercise Upregulates Extracellular Vesicles (EVs) Proteins Involved in Immunomodulatory and Mitochondrial Pathways in Human Subjects." Diabetes 72, Supplement_1 (2023). http://dx.doi.org/10.2337/db23-579-p.

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Emerging data suggest that single bouts of exercise increase circulating hormones, cytokines, and EVs, and that these circulating factors may play a fundamental role in the beneficial effects of exercise on health. Here, we identify circulating factors in response to both acute exercise and exercise training and determine the effects of nutritional status on these responses. Blood samples were first collected before and immediately after an acute bout of maximal exercise in healthy, lean subjects (N=8, 3M/5F; age=27±2, V̇O2peak=28.4±1.2ml/kg/min). Subjects then completed a 10 wk moderate-inten
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MITZNER, MARGALIT G., WARD FICKWEILER, DEVON B. ROBINSON, TAHANI BOUMENNA, LLOYD P. AIELLO, and JENNIFER SUN. "45-OR: Less Favorable Response to Anti-VEGF Therapy in Patients with Diabetic Macular Edema and Decreased Baseline Outer Retinal Layer Thickness." Diabetes 71, Supplement_1 (2022). http://dx.doi.org/10.2337/db22-45-or.

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Early identification of patients who are more likely to respond to anti-VEGF therapy for diabetic macular edema (DME) would improve patient management and allow for more rapid assessment of new therapeutic targets. This study evaluated retinal thickness variables and their association with anti-VEGF therapy response in patients with DME. We identified patients at the Joslin Diabetes Center who received their first anti-VEGF injection for DME between 1/2016-12/20 and assessed mean change in visual acuity (VA) and central retinal thickness (RT) at 6 mos. A good VA or RT response to anti-VEGF the
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Espinilla, Oscar Garcia, Pablo Arlanzón Lope, Andrea Novo Díez, et al. "Analysis of the photographers' quality control in the diabetic retinopathy screening at the IOBA's Reading Center." Acta Ophthalmologica 102, S279 (2024). http://dx.doi.org/10.1111/aos.15899.

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Aims/Purpose: Diabetic retinopathy (DR) is the most frequent ocular complication of diabetes and one of the leading causes of avoidable blindness. Teleophthalmology screening by taken retinal images is an effective tool in its early detection and delivering prompt treatment. IOBA's Reading Center (RC) of the University of Valladolid is in charge for the Regional Health System (SACYL) DR screening program. Retinographies are taken at Primary Care Centers, under mydriasis, following the three‐field Joslin Vision Network protocol by certified photographers. Quality control (QC) is an indispensabl
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CEDENO, BRIAN, EMILY FAY, NICOLE M. EHRHARDT, and STEPHANIE J. FONDA. "538-P: Use of Real-Time Continuous Glucose Monitoring Supports Behavior Modification in Gestational Diabetes Mellitus—Results from an Ongoing Pilot Study." Diabetes 72, Supplement_1 (2023). http://dx.doi.org/10.2337/db23-538-p.

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Gestational diabetes mellitus (GDM) is common, with 14% of women developing GDM. Although real-time continuous glucose monitoring (RT-CGM) has been shown to support behavioral/lifestyle modifications in patients living with type 1 and type 2 diabetes, no studies to date have assessed RT-CGM as a behavior modification tool for patients with GDM. Participants diagnosed with GDM [prior to gestational age 24 weeks (early) or between 24-30 weeks (typical)] were randomized to use RT-CGM or continue self-monitoring of blood glucose (SMBG) using finger-sticks and wore 3 serial blinded CGM over the rem
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O'DOHERTY, EMER, ATIF ADAM, ALMOG SHALIT, HETAL SHAH, GEORGE L. KING, and ROELAND J. W. MIDDELBEEK. "1302-P: Long-COVID in Type 1 and Type 2 Diabetes—Prevalence, Clinical Outcomes, and Inflammatory Marker Responses." Diabetes 73, Supplement_1 (2024). http://dx.doi.org/10.2337/db24-1302-p.

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Introduction: Diabetes significantly impacts COVID-19 morbidity and mortality, with the long-term sequelae ('long-COVID') in diabetes poorly understood. This study examines the prevalence and clinical outcomes of long-COVID, and the influence of pharmacotherapy, such as metformin use, on COVID-19 symptom persistence. Another objective is to determine inflammatory cytokine concentrations in patients with long-COVID. Methods: Adult T1D and T2D patients at Joslin Diabetes Center, USA, were surveyed for COVID-19 history with EMRs providing demographic and clinical data. Blood samples were analyzed
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Sterbenz, A., J. Fuentes Rosales, S. Abraham, et al. "12420 Effects Of A Continuous Glucose Monitoring (CGM) Optimization Program On Prescribing Behavior And Glycemic Outcomes." Journal of the Endocrine Society 8, Supplement_1 (2024). http://dx.doi.org/10.1210/jendso/bvae163.747.

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Abstract Disclosure: A. Sterbenz: None. J. Fuentes Rosales: None. S. Abraham: None. P. Siroya: None. R. Middelbeek: None. J. Mitri: None. F. Rossitto: None. E. Cabana: None. A. Gharse: None. L. Collins: None. L. Aliaga: None. A. Millan Ferro: None. J. Cifuni: None. A. Schwartz: None. E. Kelley: None. C. Gomez: None. M. Aballay: None. Introduction: Continuous glucose monitoring (CGM) improves glucose control in patients with diabetes, as demonstrated in clinical trials. There is limited information available on the real-world application of CGM adoption in a resource-limited setting or safety n
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40

NIGRO, PASQUALE, NICHOLAS P. CARBONE, CARLOS BUENO JUNIOR, et al. "596-P: Exercise Increases Plasma Neuronal Growth Regulator 1 (NEGR1) Concentrations in Human Subjects." Diabetes 72, Supplement_1 (2023). http://dx.doi.org/10.2337/db23-596-p.

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Recent studies suggest that exercise-induced circulating factors are critical for the health benefits of exercise. In rodent models, we have identified NEGR1 as a cell adhesion molecule that is essential for remodeling white adipose tissue (WAT) innervation via sympathetic neurite outgrowth, and that NEGR1 is a secreted factor that may be involved inter-tissue communication. In humans, exercise training increases NEGR1 mRNA in subcutaneous WAT, but whether exercise regulates circulating NEGR1 in humans is not known. Here, we investigated the effects of a single bout of maximal exercise and exe
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ElSayed, Nuha A., Grazia Aleppo, Vanita R. Aroda, et al. "Addendum. 3. Prevention or Delay of Type 2 Diabetes and Associated Comorbidities: Standards of Care in Diabetes—2023. Diabetes Care 2023;46(Suppl. 1):S41–S48." Diabetes Care, June 25, 2023. http://dx.doi.org/10.2337/dc23-ad08a.

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Section 3, “Prevention or Delay of Type 2 Diabetes and Associated Comorbidities,” of the Standards of Care in Diabetes—2023 has been updated based on recent U.S. Food and Drug Administration approval of a new drug to delay the incidence of type 1 diabetes. The online version of the article (https://doi.org/10.2337/dc23-S003) reflects the changes described below. Jason L. Gaglia, of Joslin Diabetes Center and Harvard Medical School, Boston, MA, has been added as an author due to his expertise in immunology and type 1 diabetes. The author list and disclosures table (p. S281) have been updated ac
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CARAPETO, PRISCILA, KANAKO IWASAKI, HUI PAN та ін. "200-OR: Targeting β-Cell Senescence and Secondary Senescence—Therapeutic Potential of JAK Inhibitors in Diabetes". Diabetes 74, Supplement_1 (2025). https://doi.org/10.2337/db25-200-or.

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Introduction and Objective: Cellular senescence is a stress response marked by the upregulation of antiapoptotic pathways, loss of function, and secretome remodeling (SASP). Pancreatic β-cells undergo senescence with age and insulin resistance, while their targeted removal improves glucose homeostasis, demonstrating the role of β-cell senescence in diabetes progression. However, β-cell senescence can also promote β-cell survival and function. Thus, a better understanding of the phenotypic and functional heterogeneity is needed to develop effective therapeutic strategies. Methods: scRNASeq of h
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SEFTEL, DAVID. "1265-P: Insights and Implications—Creating and Executing the First National-Scale Home Sample Collected Autoantibody Screening Service for Type 1 Diabetes (T1D) Risk Assessment for JDRF’s T1Detect." Diabetes 72, Supplement_1 (2023). http://dx.doi.org/10.2337/db23-1265-p.

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On December 12, 2020, a unique home-collected sample T1D autoantibody detection program was launched online. Serving 48 states, the JDRF T1Detect autoantibody screening program features a pioneering 3-year collaboration between the JDRF and a clinical reference laboratory spun out of the University of California at Berkeley and Stanford University. Using a completely novel, and now patented, way of detecting antibodies - using unique DNA barcodes that bind to antibodies and are thus readable by standard PCR machines - the T1Detect program was able to offer gold-standard-matching accuracy using
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CARAPETO, PRISCILA, JIHO KAHNG, ANA BARBARA T. ALVES WAGNER, et al. "199-OR: Exercise Decreases Mouse and Human Islet Senescence through Glucagon-Mediated AMPK Activation." Diabetes 71, Supplement_1 (2022). http://dx.doi.org/10.2337/db22-199-or.

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Aging is a major risk factor for type 2 diabetes (T2D) and cellular senescence plays a critical role in β-cell dysfunction leading to T2D. Exercise is a central component in the treatment of T2D and has been shown to attenuate many of the biochemical changes that occur with aging including senescence, but nothing is known about the effects of exercise on β-cells and their aging process. To test the hypothesis that exercise decreases β-cell senescence we used two mouse models of insulin resistance: high-fat diet (HFD, 60% kcal from fat, 6 wks) and insulin receptor antagonist S961 (40nM/wk for 2
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CARAPETO, PRISCILA, JIHO KAHNG, ANA BARBARA T. ALVES WAGNER, et al. "374-OR: Exercise Training Decreases ß-Cell Senescence in Mice and Humans." Diabetes 72, Supplement_1 (2023). http://dx.doi.org/10.2337/db23-374-or.

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Increased β-cell senescence contributes to the development of type 2 diabetes (T2D). Exercise is critical in the treatment of T2D and can attenuate aging-associated cellular changes, but exercise effects on β-cell senescence are unknown. We tested the effects of treadmill running (1h/day for 10 days) on two insulin resistance models: high-fat diet and insulin receptor antagonist (S961). Exercise improved glucose responsiveness and decreased senescence markers (SA-βGal activity, p21Cip1 and p16Ink4a mRNA and protein levels). RNAseq from pancreatic islets of exercised mice revealed decreased exp
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YU, MARC GREGORY, TAHANI BOUMENNA, JOHN GAUTHIER, et al. "94-OR: CGM Metrics, HbA1c, and Retinopathy Are Differentially Associated by Disease Duration in Long-Duration Type 1 Diabetes." Diabetes 71, Supplement_1 (2022). http://dx.doi.org/10.2337/db22-94-or.

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Continuous glucose monitor (CGM) -derived metrics provide measures of glycemic variability that are not captured with the use of HbA1c alone. However, they have not been evaluated in long-duration type 1 diabetes (T1D) subjects, in whom the greater risk of glycemic excursions and comorbidities highlight the need for other glycemic markers apart from HbA1c. Among the Joslin “Medalists” with T1D≥50 years, a single consecutive 14-day block of CGM data was remotely obtained from a subset of CGM users (n=64) after a period of routine activities. Using linear regression, mean historical HbA1c associ
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Majety, Priyanka, Ayodele Ajayi, Anna Modest, Maria Vamvini, and Jason Freed. "THU001 Novel Interactive Text-messaging Curriculum For Endocrinology Board Review." Journal of the Endocrine Society 7, Supplement_1 (2023). http://dx.doi.org/10.1210/jendso/bvad114.1526.

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Abstract Disclosure: P. Majety: None. A. Ajayi: None. A. Modest: None. M. Vamvini: Grant Recipient; Self; MV was supported by F32-DK126432, and Joslin Diabetes Center P&F. J. Freed: None. Background: The ABIM certification exam is one of the measures to ensure that physicians have the clinical skills for good care delivery. The five-year average pass rate for the ABIM Endocrinology & Metabolism subspecialty exam is 86%, relatively lower when compared to other subspecialties. The pass rate for first time test takers significantly decreased from a usual range of 84-91% over 2017-2020 to
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