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Journal articles on the topic 'Jphb'

Author: Grafiati

Published: 28 July 2024

Last updated: 31 July 2025

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1

Lehnart, Stephan E., and Xander H. T. Wehrens. "The role of junctophilin proteins in cellular function." Physiological Reviews 102, no. 3 (2022): 1211–61. http://dx.doi.org/10.1152/physrev.00024.2021.

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Junctophilins (JPHs) comprise a family of structural proteins that connect the plasma membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR). Tethering of these membrane structures results in the formation of highly organized subcellular junctions that play important signaling roles in all excitable cell types. There are four JPH isoforms, expressed primarily in muscle and neuronal cell types. Each JPH protein consists of six membrane occupation and recognition nexus (MORN) motifs, a joining region connecting these to another set of two MORN motifs, a putative alp

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2

Rossi, Daniela, Angela Maria Scarcella, Enea Liguori, et al. "Molecular determinants of homo- and heteromeric interactions of Junctophilin-1 at triads in adult skeletal muscle fibers." Proceedings of the National Academy of Sciences 116, no. 31 (2019): 15716–24. http://dx.doi.org/10.1073/pnas.1820980116.

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In adult skeletal muscles, 2 junctophilin isoforms (JPH1 and JPH2) tether the sarcoplasmic reticulum (SR) to transverse tubule (T-tubule) membranes, generating stable membrane contact sites known as triads. JPHs are anchored to the membrane of the SR by a C-terminal transmembrane domain (TMD) and bind the T-tubule membrane through their cytosolic N-terminal region, which contains 8 lipid-binding (MORN) motifs. By combining expression of GFP-JPH1 deletion mutants in skeletal muscle fibers with in vitro biochemical experiments, we investigated the molecular determinants of JPH1 recruitment at tr

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3

Garbino, Alejandro, Ralph J. van Oort, Sayali S. Dixit, Andrew P. Landstrom, Michael J. Ackerman, and Xander H. T. Wehrens. "Molecular evolution of the junctophilin gene family." Physiological Genomics 37, no. 3 (2009): 175–86. http://dx.doi.org/10.1152/physiolgenomics.00017.2009.

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Junctophilins (JPHs) are members of a junctional membrane complex protein family important for the physical approximation of plasmalemmal and sarcoplasmic/endoplasmic reticulum membranes. As such, JPHs facilitate signal transduction in excitable cells between plasmalemmal voltage-gated calcium channels and intracellular calcium release channels. To determine the molecular evolution of the JPH gene family, we performed a phylogenetic analysis of over 60 JPH genes from over 40 species and compared conservation across species and different isoforms. We found that JPHs are evolutionary highly cons

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4

Kanazawa, Yuji, Tatsuo Takahashi, Mamoru Nagano, Satoshi Koinuma, and Yasufumi Shigeyoshi. "The Effects of Aging on Sarcoplasmic Reticulum-Related Factors in the Skeletal Muscle of Mice." International Journal of Molecular Sciences 25, no. 4 (2024): 2148. http://dx.doi.org/10.3390/ijms25042148.

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The pathogenesis of sarcopenia includes the dysfunction of calcium homeostasis associated with the sarcoplasmic reticulum; however, the localization in sarcoplasmic reticulum-related factors and differences by myofiber type remain unclear. Here, we investigated the effects of aging on sarcoplasmic reticulum-related factors in the soleus (slow-twitch) and gastrocnemius (fast-twitch) muscles of 3- and 24-month-old male C57BL/6J mice. There were no notable differences in the skeletal muscle weight of these 3- and 24-month-old mice. The expression of Atp2a1, Atp2a2, Sln, and Pln increased with age

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Muangrod, Pratchaya, Wiriya Charoenchokpanich, Vilai Rungsardthong, et al. "Effect of pepsin hydrolysis on antioxidant activity of jellyfish protein hydrolysate." E3S Web of Conferences 302 (2021): 02010. http://dx.doi.org/10.1051/e3sconf/202130202010.

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Edible jellyfish have been consumed as food for more than a century with offering high protein and crunchy texture. The pepsin hydrolysis of jellyfish protein yields jellyfish protein hydrolysate (ep-JPH), reported for potential bioactivities such as antioxidant activity or antihypertensive activities. Due to the substantial number of by-products generated from jellyfish processing, the by-products were then selected as a raw material of JPH production. This research aimed to evaluate the effect of the hydrolysis time of pepsin on the antioxidant activity of ep-JPH. The dried desalted jellyfis

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6

Gross, Polina, Jaslyn Johnson, Carlos M. Romero, et al. "Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca 2+ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca 2+ Dynamics." Circulation Research 128, no. 1 (2021): 92–114. http://dx.doi.org/10.1161/circresaha.119.315715.

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Rationale: Ca 2+ -induced Ca 2+ release (CICR) in normal hearts requires close approximation of L-type calcium channels (LTCCs) within the transverse tubules (T-tubules) and RyR (ryanodine receptors) within the junctional sarcoplasmic reticulum. CICR is disrupted in cardiac hypertrophy and heart failure, which is associated with loss of T-tubules and disruption of cardiac dyads. In these conditions, LTCCs are redistributed from the T-tubules to disrupt CICR. The molecular mechanism responsible for LTCCs recruitment to and from the T-tubules is not well known. JPH (junctophilin) 2 enables close

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7

Feng, Yu, Yan Chen, Binrui Yang, et al. "Hepatoprotective Effect of Jianpi Huoxue Formula on Nonalcoholic Fatty Liver Disease Induced by Methionine-Choline-Deficient Diet in Rat." BioMed Research International 2019 (July 1, 2019): 1–12. http://dx.doi.org/10.1155/2019/7465272.

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In parallel with the prevalence metabolic syndrome, nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in most countries. It features a constellation of simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and even hepatocellular carcinoma. There are no approved drugs for effective management of NAFLD and NASH. Jianpi Huoxue formula (JPHX) mainly consists of Atractylodes macrocephal(Baizhu), Salvia miltiorrhiza (Danshen), Rasux Paeonia Alba (Baishao), Rhizoma Alismatis (Zexie), and Fructus Schisandrae Chinensis (Wuweizi), which may

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8

Pritchard, Harry A. T., Caoimhin S. Griffin, Evan Yamasaki, et al. "Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility." Proceedings of the National Academy of Sciences 116, no. 43 (2019): 21874–81. http://dx.doi.org/10.1073/pnas.1911304116.

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Junctophilin proteins maintain close contacts between the endoplasmic/sarcoplasmic reticulum (ER/SR) and the plasma membrane in many types of cells, as typified by junctophilin-2 (JPH2), which is necessary for the formation of the cardiac dyad. Here, we report that JPH2 is the most abundant junctophilin isotype in native smooth muscle cells (SMCs) isolated from cerebral arteries and that acute knockdown diminishes the area of sites of interaction between the SR and plasma membrane. Superresolution microscopy revealed nanometer-scale colocalization of JPH2 clusters with type 2 ryanodine recepto

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9

Huang, Yajing, Cheng Zhou, Huihong Wen, et al. "Jianpi-Huayu Formula Inhibits Development of Hepatocellular Carcinoma by Regulating Expression of miR-602, Which Targets the RASSF1A Gene." Integrative Cancer Therapies 19 (January 2020): 153473541990080. http://dx.doi.org/10.1177/1534735419900804.

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The traditional Chinese medicine formula Jianpi-Huayu (JPHY) has been reported to be effective in the treatment of hepatocellular carcinoma (HCC). However, its underlying mechanism remains unclear. In this article, we employed an orthotopic transplantation model in nude mice to explore whether JPHY could inhibit the development of HCC by regulating miR-602, which targets the Ras association domain-containing protein 1A (RASSF1A) pathway. HCC SMMC-7721 cells were treated with JPHY to test whether the RASSF1A gene as mediated by miR-602 affected the proliferation and apoptosis of tumor cells. We

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10

Siham, Muhammed Ali. "Evaluating the functional and genomic analysis of pathogenic junctophilin-2 variants and their association with the pathogenesis of cardiomyopathy to understand their molecular impact on cardiac calcium homeostasis and disease phenotypes." Annals of Pediatric Cardiology 17, no. 6 (2024): 401–7. https://doi.org/10.4103/apc.apc_173_24.

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ABSTRACT The growing body of evidence suggests that junctophilin-2 (JPH2) variants hold significant potential for diagnostic and therapeutic interventions, particularly within the framework of personalized medicine and genetic screening across diverse populations. Mutations in JPH2 have been associated with a range of clinical phenotypes including early-onset heart failure and cardiomyopathies, a diverse group of diseases affecting heart muscle structure and function that contribute to heart failure and sudden cardiac death. While traditional understanding has centered on sarcomeric gene mutat

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11

Valtonen, Joona, Chandra Prajapati, Reeja Maria Cherian, et al. "The Junctophilin-2 Mutation p.(Thr161Lys) Is Associated with Hypertrophic Cardiomyopathy Using Patient-Specific iPS Cardiomyocytes and Demonstrates Prolonged Action Potential and Increased Arrhythmogenicity." Biomedicines 11, no. 6 (2023): 1558. http://dx.doi.org/10.3390/biomedicines11061558.

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Hypertrophic cardiomyopathy (HCM) is one of the most common genetic cardiac diseases; it is primarily caused by mutations in sarcomeric genes. However, HCM is also associated with mutations in non-sarcomeric proteins and a Finnish founder mutation for HCM in non-sarcomeric protein junctophilin-2 (JPH2) has been identified. This study aimed at assessing the issue of modelling the rare Finnish founder mutation in cardiomyocytes (CMs) differentiated from iPSCs; therefore, presenting the same cardiac abnormalities observed in the patients. To explore the abnormal functions in JPH2-HCM, skin fibrob

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12

Wang, Wei, Andrew P. Landstrom, Qiongling Wang, et al. "Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice." American Journal of Physiology-Heart and Circulatory Physiology 307, no. 9 (2014): H1317—H1326. http://dx.doi.org/10.1152/ajpheart.00413.2014.

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Expression silencing of junctophilin-2 (JPH2) in mouse heart leads to ryanodine receptor type 2 (RyR2)-mediated sarcoplasmic reticulum (SR) Ca2+ leak and rapid development of heart failure. The mechanism and physiological significance of JPH2 in regulating RyR2-mediated SR Ca2+ leak remains elusive. We sought to elucidate the role of JPH2 in regulating RyR2-mediated SR Ca2+ release in the setting of cardiac failure. Cardiac myocytes isolated from tamoxifen-inducible conditional knockdown mice of JPH2 (MCM-shJPH2) were subjected to confocal Ca2+ imaging. MCM-shJPH2 cardiomyocytes exhibited an i

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13

Ferrell, Betty. "Publishing in JPHN." Journal of Hospice & Palliative Nursing 12, no. 2 (2010): 79–80. http://dx.doi.org/10.1097/njh.0b013e3181d5ebd7.

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14

Jayasinghe, Isuru D., Michelle Munro, David Baddeley, Bradley S. Launikonis, and Christian Soeller. "Observation of the molecular organization of calcium release sites in fast- and slow-twitch skeletal muscle with nanoscale imaging." Journal of The Royal Society Interface 11, no. 99 (2014): 20140570. http://dx.doi.org/10.1098/rsif.2014.0570.

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Localization microscopy is a fairly recently introduced super-resolution fluorescence imaging modality capable of achieving nanometre-scale resolution. We have applied the dSTORM variation of this method to image intracellular molecular assemblies in skeletal muscle fibres which are large cells that critically rely on nanoscale signalling domains, the triads. Immunofluorescence staining in fixed adult rat skeletal muscle sections revealed clear differences between fast- and slow-twitch fibres in the molecular organization of ryanodine receptors (RyRs; the primary calcium release channels) with

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15

Kwon, David. "Human Security." Journal for Peace and Justice Studies 29, no. 2 (2019): 3–24. http://dx.doi.org/10.5840/peacejustice201929214.

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There is a growing discussion of the idea of jus post bellum (jpb) and what it means as an addition to just war thinking. This essay connects jpb to the thought of Augustine and Aquinas, so that jpb appears as integral in that tradition. To make this case, I argue that achieving jpb is key to building a just peace, of which the fundamental characteristic must be human security, and thus defines two approaches to the study of human security that emerges from the theological development of jpb ethics: Michael Schuck’s Augustinian and Kenneth Himes’s Thomistic jpb conceptions. I argue that they b

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16

Teng, Lichao, Xueqin Wang, Huahua Yu, et al. "Jellyfish Peptide as an Alternative Source of Antioxidant." Antioxidants 12, no. 3 (2023): 742. http://dx.doi.org/10.3390/antiox12030742.

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Jellyfish is a valuable biological resource in marine ecosystems, and blooms been observed in numerous coastal regions. However, their utility is limited by their high water content. Recent research has focused on extracting antioxidants from marine sources. In this study, we obtained jellyfish peptides (JPHT-2) through enzymatic hydrolysis of lyophilized jellyfish powder under optimal conditions and measured their antioxidant activity. Our findings indicate that JPHT-2 possesses significant radical-scavenging activity and reducing power. At a concentration of 0.74 mg/mL, JPHT-2 exhibited a re

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17

Yang, Lei, Rong-Chang Li, Bin Xiang, et al. "Transcriptional regulation of intermolecular Ca2+signaling in hibernating ground squirrel cardiomyocytes: The myocardin–junctophilin axis." Proceedings of the National Academy of Sciences 118, no. 14 (2021): e2025333118. http://dx.doi.org/10.1073/pnas.2025333118.

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The contraction of heart cells is controlled by the intermolecular signaling between L-type Ca2+channels (LCCs) and ryanodine receptors (RyRs), and the nanodistance between them depends on the interaction between junctophilin-2 (JPH2) in the sarcoplasmic reticulum (SR) and caveolin-3 (CAV3) in the transversal tubule (TT). In heart failure, decreased expression of JPH2 compromises LCC–RyR communication leading to deficient blood-pumping power. In the present study, we found that JPH2 and CAV3 transcription was concurrently regulated by serum response factor (SRF) and myocardin. In cardiomyocyte

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18

Indra Wijaya, Yusup, Rina Alfah, and Mayang Sari. "IMPLEMENTASI JPCB (JOB PROGRESS CONTROL BOARD) ONLINE PADA LAYANAN SERVIS MOBIL BANJARMASIN." Technologia : Jurnal Ilmiah 13, no. 1 (2022): 36. http://dx.doi.org/10.31602/tji.v13i1.6123.

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Peningkatan pelayanan untuk kepuasan pelanggan adalah tujuan utama dalam layanan servis sebuah perusahaan. Perlu adanya suatu sistem terintegrasi berbasis online yang memudahkan komunikasi antar kustomer dengan layanan servis mobil yang mereka gunakan. Sebelumnya , JPCB (Job Progress Control Board) mereka lakukan dengan menulis pada Board di workshop dengan status dan apa saja pekerjan serta spartpart yang di ganti serta apakah pekerjaan servis sudah selesai atau belum. Maka dibuat lah sistem yaitu JPCB Online yang dapat diakses melalui Komputer/tablet yang sudah disediakan oleh bengkel. Siste

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19

Veselý, Jan. "NUMERICAL MODELLING OF THE SOIL BEHAVIOUR BY USING NEWLY DEVELOPED ADVANCED MATERIAL MODEL." Acta Polytechnica 57, no. 1 (2017): 58–70. http://dx.doi.org/10.14311/ap.2017.57.0058.

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This paper describes a theoretical background, implementation and validation of the newly developed Jardine plastic hardening-softening model (JPHS model), which can be used for numerical modelling of the soils behaviour. Although the JPHS model is based on the elasto-plastic theory, like the Mohr-Coulomb model that is widely used in geotechnics, it contains some improvements, which removes the main disadvantages of the MC model. The presented model is coupled with an isotopically hardening and softening law, non-linear elastic stress-strain law, non-associated elasto-plastic material descript

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20

Goodyear-Smith, Felicity. "Editorial: JPHC achieves MEDLINE status." Journal of Primary Health Care 2, no. 3 (2010): 178. http://dx.doi.org/10.1071/hc10178.

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21

Rohmah, Siti. "THE PATTERN OF ABSORPTION OF ISLAMIC LAW INTO NATIONAL LAW: Study of The Halal Product Guarantee Law in The Perspective of Maqashid Shari’ah." JURISDICTIE 12, no. 1 (2021): 20–47. http://dx.doi.org/10.18860/j.v12i1.10521.

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The transformation of Islamic Law into the Halal Product Guarantee or Jaminan Produk Halal (JPH) Law is unique. Muslim minorities in Indonesia worry that the JPH Law is no longer voluntary but mandatory. The state acts as a regulator and an operator at the same time. This is because the JPH Law is derived from Islamic law but is intended for both Muslim and non-Muslim producers, in national and international context. This research aims to analyze the pattern of absorption of Islamic law in the jurisprudence provisions of halal products into the JPH Law and to review it from the perspective of

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22

Vetter, N. "Editing the JPH." Journal of Public Health 29, no. 3 (2007): 215–17. http://dx.doi.org/10.1093/pubmed/fdm052.

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23

Kawamura, S. "Briefing outside JPB." Journal of Photochemistry and Photobiology B: Biology 6, no. 4 (1990): 453. http://dx.doi.org/10.1016/1011-1344(90)85120-l.

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24

Spikes, JohnD. "Briefing outside JPB." Journal of Photochemistry and Photobiology B: Biology 7, no. 2-4 (1990): 369. http://dx.doi.org/10.1016/1011-1344(90)85172-s.

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Hölzle, Erhard. "Briefing outside JPB." Journal of Photochemistry and Photobiology B: Biology 8, no. 2 (1991): 227. http://dx.doi.org/10.1016/1011-1344(91)80065-p.

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Pottier, RoyH. "Briefing outside JPB." Journal of Photochemistry and Photobiology B: Biology 8, no. 3 (1991): 343. http://dx.doi.org/10.1016/1011-1344(91)80095-y.

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27

Häder, Donat-P. "Briefing outside JPB." Journal of Photochemistry and Photobiology B: Biology 8, no. 4 (1991): 447. http://dx.doi.org/10.1016/1011-1344(91)80122-x.

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Tyrrell, RexM. "Briefing outside JPB." Journal of Photochemistry and Photobiology B: Biology 10, no. 3 (1991): 275. http://dx.doi.org/10.1016/1011-1344(91)85010-e.

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29

Mercado, Javier E., Beatriz Ortiz-Santana, and Shannon L. Kay. "Endemic Jeffrey Pine Beetle Associates: Beetle/Mite Fungal Dissemination Strategies and Interactions That May Influence Beetle Population Levels." Microorganisms 9, no. 8 (2021): 1641. http://dx.doi.org/10.3390/microorganisms9081641.

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Fungal and mite associates may drive changes in bark beetle populations, and mechanisms constraining beetle irruptions may be hidden in endemic populations. We characterized common fungi of endemic-level Jeffrey pine beetle (JPB) in western USA and analyzed their dissemination by JPB (maxillae and fecal pellet) and fungivorous mites to identify if endogenous regulation drove the population. We hypothesized that: (1) as in near-endemic mountain pine beetle populations, JPB’s mutualistic fungus would either be less abundant in endemic than in non-endemic populations or that another fungus may be

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30

Angervall, Petra. "This is JPHE, 3(1), 2021." Journal of Praxis in Higher Education 3, no. 1 (2021): 1–4. http://dx.doi.org/10.47989/kpdc139.

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31

Sabater-Molina, M., M. Navarro, E. García-Molina Sáez, et al. "Mutation in JPH2 cause dilated cardiomyopathy." Clinical Genetics 90, no. 5 (2016): 468–69. http://dx.doi.org/10.1111/cge.12825.

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Angervall, Petra, Dennis Dennis, Maresi Maresi, and Marko Turk. "Celebrating JPHE: Past, present, and future." Journal of Praxis in Higher Education 6, no. 5 (2024): 1–9. https://doi.org/10.47989/kpdc658.

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33

Strömberg Jämsvi, Susanne. "Openness and open access in JPHE." Journal of Praxis in Higher Education 7, no. 1 (2025): 1–5. https://doi.org/10.47989/kpdc676.

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Silva-Villar, Luis, and Susana Silva Villar. "Pérez Hervás: borrado del mapa, y del Espasa." Estudios de Lingüística del Español 36 (June 1, 2015): 485–95. http://dx.doi.org/10.36950/elies.2015.36.8697.

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Hemos oído y leído hasta la saciedad que la obra cumbre de la cultura enciclopédica española, la Enciclopedia universal ilustrada europeo-americana (1908-1933), de la editorial Espasa Calpe, ha mantenido inalterado a lo largo de sus numerosas reimpresiones su cuerpo histórico de 72 volúmenes y 10 apéndices. Nuestra investigación demuestra que esto no puede ser cierto. El hallazgo en Google Books de una entrada enciclopédica del Espasa del escritor, traductor y lexicógrafo José Pérez Hervás (JPH) lo avala. Una previa búsqueda del autor en la enciclopedia había dado resultado negativo, hecho tam

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Ueno, M., N. Sawada, M. Inoue, S. Tsugane, and Y. Kawaguchi. "Association between Adult¡¦s Height and Dentition Status- JPHC Oral Health Study." Asian Pacific Journal of Health Sciences 3, Supplimentary 2016 (2016): 81–88. http://dx.doi.org/10.21276/apjhs.2016.3.4s.12.

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Rivera, Caroline N., Carly E. Smith, Lillian V. Draper, et al. "The Selective LAT1 Inhibitor JPH203 Enhances Mitochondrial Metabolism and Content in Insulin-Sensitive and Insulin-Resistant C2C12 Myotubes." Metabolites 13, no. 6 (2023): 766. http://dx.doi.org/10.3390/metabo13060766.

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Population data have shown an association between higher circulating branched-chain amino acids (BCAA) and the severity of insulin resistance in people with diabetes. While several studies have assessed BCAA metabolism as a potential target for regulation, less attention has been paid to the role of L-type amino acid transporter 1 (LAT1), the primary transporter of BCAA in skeletal muscle. The aim of this study was to assess the impact of JPH203 (JPH), a LAT1 inhibitor, on myotube metabolism in both insulin-sensitive and insulin-resistant myotubes. C2C12 myotubes were treated with or without 1

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37

Gibbs, Neil K. "In this of JPB." Journal of Photochemistry and Photobiology B: Biology 39, no. 2 (1997): III—IV. http://dx.doi.org/10.1016/s1011-1344(97)83319-2.

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Akbari, Ozie Karunia, Ali Sahab, Hari Fitrianto, Febby Risti Widjayanto, and Adam Mochammad Naufal. "policy implementation of law no. 33 of 2014 concerning halal product guarantees (UU JPH) for micro-small businesses in the food and beverage sector in Surabaya city." Journal of Halal Product and Research 7, no. 2 (2024): 210–14. https://doi.org/10.20473/jhpr.vol.7-issue.2.210-214.

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Micro and small enterprises (MSEs) are a sector that is important to the country's economy. Despite the limited resources, MSEs have resilience to economic crises. This research focuses on a policy implementation study of Law No. 33 of 2014 concerning Halal Product Guarantee (JPH Law) on micro and small scale businesses in the food and beverage in Surabaya City. This research raises two problem formulations, the role played by stakeholders in this law to increase halal certificates of micro small businesses in the food and beverage in Surabaya City and the obstacles faced by stakeholders in in

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39

Freeman, Phyllis, and Anthony Robbins. "The End of an Era for JPHP." Journal of Public Health Policy 28, no. 1 (2007): 1. http://dx.doi.org/10.1057/palgrave.jphp.3200112.

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40

Jungwirth, Pavel, and Martin T. Zanni. "Editorial - Virtual Issue of JPCB on Biophysics." Journal of Physical Chemistry B 121, no. 5 (2017): 913–14. http://dx.doi.org/10.1021/acs.jpcb.6b12749.

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41

Martin, Sarah A. "Reporting Guidelines: In the Future for JPHC?" Journal of Pediatric Health Care 28, no. 2 (2014): 111–12. http://dx.doi.org/10.1016/j.pedhc.2013.11.004.

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Swartz, Martha K. "Transitions Within the JPHC Editorial Advisory Board." Journal of Pediatric Health Care 29, no. 4 (2015): 309. http://dx.doi.org/10.1016/j.pedhc.2015.05.001.

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Roberts, Robert. "JPH2 Mutant Gene Causes Familial Hypertrophic Cardiomyopathy." JACC: Basic to Translational Science 2, no. 1 (2017): 68–70. http://dx.doi.org/10.1016/j.jacbts.2016.11.007.

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44

Hu, Junping, Min Jiang, and Tseng Gea-Ny. "Mechanism and Regulation of JPH2/PM Association." Biophysical Journal 114, no. 3 (2018): 382a—383a. http://dx.doi.org/10.1016/j.bpj.2017.11.2117.

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Perni, Stefano, and Kurt G. Beam. "Voltage-induced Ca2+ release is supported by junctophilins 1, 2 and 3, and not by junctophilin 4." Journal of General Physiology 154, no. 9 (2021). http://dx.doi.org/10.1085/jgp.2021ecc22.

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In skeletal muscle, depolarization of the plasma membrane (PM) causes conformational changes of the calcium channel CaV1.1, which then activate RYR1 to release calcium from the sarcoplasmic reticulum (SR). Because it does not require extracellular calcium entry, this process is termed voltage-induced calcium release. In skeletal muscle, junctophilins (JPH) 1 and 2 are responsible for forming the SR–PM junctions at which voltage-induced calcium release occurs; structurally similar junctions with different molecular constituents are formed in neurons by JPH3 and JPH4. Studies on mice models demo

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Perni, Stefano, and Kurt Beam. "Junctophilins 1, 2, and 3 all support voltage-induced Ca2+ release despite considerable divergence." Journal of General Physiology 154, no. 9 (2022). http://dx.doi.org/10.1085/jgp.202113024.

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In skeletal muscle, depolarization of the plasma membrane (PM) causes conformational changes of the calcium channel CaV1.1 that then activate RYR1 to release calcium from the SR. Being independent of extracellular calcium entry, this process is termed voltage-induced calcium release. In skeletal muscle, junctophilins (JPHs) 1 and 2 form the SR–PM junctions at which voltage-induced calcium release occurs. Previous work demonstrated that JPH2 is able to recapitulate voltage-induced calcium release when expressed in HEK293 cells together with CaV1.1, β1a, Stac3, and RYR1. However, it is unknown w

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Yang, Zheng Fang, Pankaj Panwar, Ciaran R. McFarlane, Wietske E. Tuinte, Marta Campiglio, and Filip Van Petegem. "Structures of the junctophilin/voltage-gated calcium channel interface reveal hot spot for cardiomyopathy mutations." Proceedings of the National Academy of Sciences 119, no. 10 (2022). http://dx.doi.org/10.1073/pnas.2120416119.

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Significance Ion channels have evolved the ability to communicate with one another, either through protein–protein interactions, or indirectly via intermediate diffusible messenger molecules. In special cases, the channels are part of different membranes. In muscle tissue, the T-tubule membrane is in proximity to the sarcoplasmic reticulum, allowing communication between L-type calcium channels and ryanodine receptors. This process is critical for excitation–contraction coupling and requires auxiliary proteins like junctophilin (JPH). JPHs are targets for disease-associated mutations, most not

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Perni, Stefano, and Kurt Beam. "Neuronal junctophilins recruit specific CaV and RyR isoforms to ER-PM junctions and functionally alter CaV2.1 and CaV2.2." eLife 10 (March 26, 2021). http://dx.doi.org/10.7554/elife.64249.

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Junctions between the endoplasmic reticulum and plasma membrane that are induced by the neuronal junctophilins are of demonstrated importance, but their molecular architecture is still poorly understood and challenging to address in neurons. This is due to the small size of the junctions and the multiple isoforms of candidate junctional proteins in different brain areas. Using colocalization of tagged proteins expressed in tsA201 cells, and electrophysiology, we compared the interactions of JPH3 and JPH4 with different calcium channels. We found that JPH3 and JPH4 caused junctional accumulatio

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Tammineni, Eshwar R., Lourdes Figueroa, Natalia Kraeva, et al. "Fragmentation and roles of junctophilin1 in muscle of patients with cytosolic leak of stored calcium." Journal of General Physiology 154, no. 9 (2021). http://dx.doi.org/10.1085/jgp.2021ecc32.

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The mechanisms that link the primary increase in SR Ca2+ leak of MH susceptibility and related conditions to their disease phenotypes are not well understood. We found that abnormal Ca2+ homeostasis in MHS individuals induces proteolysis of junctophilin1 (JPh1), an essential structural protein of EC coupling (Perni, in 2017). Guo (in 2018) and Lahiri (in 2020) reported similar fragmentation of JPh2 in stressed hearts. Western blot of patients’ muscle with domain-specific antibodies showed a deficit of full-length JPh1 and excess of a 44-kD C-terminal fragment (JPh44) in MHS subjects. While JPh

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Resendiz, Lira Pedro Alberto. "Inverse Approach to Spacecraft Charging Simulations Appendix." September 12, 2022. https://doi.org/10.5281/zenodo.7072542.

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Synthetic Cases used to illustrate the inverse charging technique. Data structure in files: Case_X.dat: contains density and spacecraft potential in the first and second column respectively.. Case_X_ia.dat: contains the illuminated area with respect to the total spacecraft area. Case_X_Te_ref.out: contains the electron temperature as a function of time (normalized). Case_X_solar.out: contains the temperature (Tph) and current density (Jph) of the photoelectrons in the first and second row respectively. In the case of the two material case in section 3.6, the second set of material parameters a

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