Relevant bibliographies by topics / Juglona

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Juglona'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Juglona"

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Shamilov, E. N., A. S. Abdullayev, I. A. Rzayeva, and I. V. Azizov. "Вплив комплексів заліза на формування фотосинтетичного апарату та вихід генетичних змін у гамма-опроміненого насіння пшениці." Visnyk of Dnipropetrovsk University. Biology, medicine 1, no. 2 (July 18, 2010): 90–95. http://dx.doi.org/10.15421/021037.

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Influence of various doses of γ-irradiation on biosynthesis of chlorophyll and carotinoids, and also on a progress of mitotic divisions of meristematic cells of root hairs at sprouting wheat seeds at the presence of pyrocatechol, iron pyrocatecholat, thiocarbamide, iron thiocarbamide, rutine, iron rutinate, juglon and iron juglonate was studied. There was revealed that iron pyrocatecholate, iron rutinate, juglon and iron juglonate possess appreciable radioprotective properties which stimulate adaptive biosynthesis of chlorophyll and carotinoids, and also considerably reduce a number of chromosomal aberrations under irradiation.
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Matławska, Irena, Wiesława Bylka, Ewa Widy-Tyszkiewicz, and Beata Stanisz. "Determination of the Juglone Content of Juglans regia Leaves by GC/MS." Natural Product Communications 10, no. 7 (July 2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000726.

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The constituents of walnut (Juglans regia L.) leaves are represented by tannins, phenolics, and naphthoquinones, the characteristic compound being juglone. The content of juglone in the methanolic extract of the leaves determined by the GC/MS method was 9.9±0.2 mg/100 g; small amounts (1.3±0.02 mg/100 g) were recorded in the infusion, whereas in the decoction it was not detected. As some studies indicate toxicity of juglone, only decoctions should be recommended for therapeutic use.
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Wang, Jin Lan, Zhong Jin Yang, Jian Jun Wang, Wan Xia Tang, Ming Zhao, and Shu Jun Zhang. "Synthesis of Juglone and its Derivatives." Applied Mechanics and Materials 138-139 (November 2011): 1139–41. http://dx.doi.org/10.4028/www.scientific.net/amm.138-139.1139.

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Juglone (1), plumbagin (2) and isoplumbagin (3) were synthesized from the natural product 4,8-dihydroxy naphthol-β-D-glucoside (4) which existed large amount in barks of Juglans mandshurica. Juglone was achieved directly by deglycosylation catalyzing with CAS in 78 % yield. Plumbagin was synthesized by five steps with an overall yield of 22 %. Isoplumbagin was synthesized by six steps in 24 % yield.
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Chaudhary, Niraj, Ryoko Sasaki, Tsuyoshi Shuto, Masato Watanabe, Teppei Kawahara, Mary Suico, Takeshi Yokoyama, Mineyuki Mizuguchi, Hirofumi Kai, and Hari Devkota. "Transthyretin Amyloid Fibril Disrupting Activities of Extracts and Fractions from Juglans mandshurica Maxim. var. cordiformis (Makino) Kitam." Molecules 24, no. 3 (January 30, 2019): 500. http://dx.doi.org/10.3390/molecules24030500.

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Transthyretin-related amyloidosis is a slowly progressive disorder caused by deposition of insoluble amyloid plaques formed by fibrillization of mutant or defective transthyretin (TTR) monomers that leads to neurodegeneration and organ failure. Thus, any compound exhibiting TTR amyloid formation inhibitory activity or TTR amyloid fibril disrupting activity might be a potential candidate for the development of therapies for these disorders. Our aim in this study was the evaluation of the TTR amyloid fibril disrupting potential of extracts of leaves and immature fruits of two Juglans plants, i.e., Juglans mandshurica var. sachalinensis and Juglans mandshurica var. cordiformis. The TTR amyloid fibril disrupting activity was measured by Thioflavin-T (ThT) assay and PROTEOSTAT® Protein aggregation assay methods. A fifty percent acetone extract of the fruits of Juglans mandshurica var. cordiformis showed strong amyloid fibril disrupting activity, and was further fractionated using different solvents. Ethyl acetate and n-butanol fractions showed significant activity in both assays. Syringic acid was isolated and identified as main compound in both of these fractions; however, it did not show any activity. Furthermore, some of the previously reported compounds from Juglans plants including naphthoquinone derivatives and phenolic compounds were evaluated to identify the potential bioactive compounds. Among them, juglone, a naphthoquinone derivative showed promising activity. However, juglone also showed strong cytotoxicity in HEK293 cells. Thus, future studies should focus on the isolation and identification of naphthoquinone derivatives or other compounds from Juglans plan ts with potent bioactivity and low cytotoxicity.
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Moore, M. J., M. E. Ostry, A. D. Hegeman, and A. C. Martin. "Inhibition of Ophiognomonia clavigignenti-juglandacearum by Juglans Species Bark Extracts." Plant Disease 99, no. 3 (March 2015): 401–8. http://dx.doi.org/10.1094/pdis-06-14-0642-re.

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A rapid and reliable technique is needed for identifying butternut trees (Juglans cinerea) with resistance to butternut canker. We investigated the potential of a bark extract bioassay to detect levels of resistance to Ophiognomonia clavigignenti-juglandacearum (Oc-j), the causal agent of butternut canker. Both reagent grade naphthoquinones and crude bark extracts of Juglans species inhibited germination of Oc-j conidia. A disc diffusion bioassay was used to study the level of inhibition by these bark extracts and results indicated extensive variation within and between butternut and other species of Juglans tested. In many months over a 3 year period, bark from butternut trees selected for apparent disease resistance could be distinguished from that of unselected trees. Inhibition of conidia germination roughly correlated to the level of resistance observed in field inoculations of the trees. Quantification of the naphthoquinone compounds juglone and plumbagin in butternut bark was performed using ultra-high performance liquid chromatography mass spectrometry. While the concentrations of these two compounds varied by month and by individual tree, juglone levels correlated well with the bark extract bioassay in some months. These results suggest that juglone concentration may account in part for the observed range of inhibition observed in the bioassay and variation in canker resistance among selections of butternut field inoculated with Oc-j. The bark extract bioassay described in the following report may have potential use for selecting resistant butternut for conservation and restoration purposes.
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Zhang, Wei, Anheng Liu, Yan Li, Xingyu Zhao, Shijie Lv, Wenhe Zhu, and Ying Jin. "Anticancer activity and mechanism of juglone on human cervical carcinoma HeLa cells." Canadian Journal of Physiology and Pharmacology 90, no. 11 (November 2012): 1553–58. http://dx.doi.org/10.1139/y2012-134.

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Induction of apoptosis in tumor cells has become the major focus of anti-tumor therapeutics development. Juglone, a major chemical constituent of Juglans mandshurica Maxim, possesses several bioactivities, including anti-tumor. In the present study, HeLa cells were incubated with juglone at various concentrations. The proliferation inhibition of juglone on HeLa cells was tested by the MTT assay. Occurrence of apoptosis was detected by Hoechst 33258 staining, flow cytometry, and transmission electron microscopy. The expression of apoptotic-related proteins was examined by Western blot. The results showed that juglone inhibits the growth of HeLa cells in dose–dependent manner. Topical morphological changes of apoptotic body formation after juglone treatment were observed. The percentages of early apoptosis of Annexin V-FITC were 5.23%, 7.95%, 10.69%, and 20.92% with the concentrations of juglone (12.5, 25, 50, and 100 µmol/L), respectively. After cells were treated with juglone at the different dose for 24 h, the expression of Bcl-2 was significantly down-regulated and the expression of Bax was significantly up-regulated compared with the control. These events paralleled with activation of caspase-9, -8, -3, and PARP cleavage. The results suggest that juglone may be effective for the treatment of HeLa cells.
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Medic, Aljaz, Tilen Zamljen, Ana Slatnar, Metka Hudina, and Robert Veberic. "Is Juglone the Only Naphthoquinone in Juglans regia L. with Allelopathic Effects?" Agriculture 11, no. 8 (August 17, 2021): 784. http://dx.doi.org/10.3390/agriculture11080784.

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We investigated whether juglone is the only allelochemical in a leaf extract from the walnut (Juglans regia L.). This was achieved through comparisons of the effects of pure juglone (1 mM, 100 μM, 10 μM control juglone) and J. regia leaf extract (prepared as 1 mM, 100 μM leaf juglone) on seed germination, seedling growth, and secondary metabolism of the selected crop vegetables. Two control treatments were also applied, as extraction medium and water. For inhibition of seed germination, S. lycopersicum, B. rapa var. japonica, and V. locusta were more sensitive to 1 mM leaf juglone, and L. sativa was more sensitive to 1 mM control juglone. This suggests that this walnut leaf extract contains specific phenolic substance(s) that can stimulate seed germination in some species and inhibit it in others. Seedling length was more sensitive to 1 mM leaf juglone than 1 mM control juglone, with selective strong inhibition of root length versus shoot length by 1 mM control juglone. Juglone also had significant effects on the secondary metabolism of L. sativa, in particular for seedlings treated with 100 μM control juglone, with marked decreases in all secondary metabolites studied. Flavonols constituted the majority of these metabolites in L. culinaris, which showed the least sensitivity to both control juglone and leaf juglone treatments. Thirty compounds were identified and quantified in S. lycopersicum, L. culinaris, and L. sativa, some for the first time in these plants, and all for the first time in the seedlings of these crop vegetables.
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Ercisli, S., A. Esitken, C. Turkkal, and E. Orhan. "The allelopathic effects of juglone and walnut leaf extracts on yield, growth, chemical and PNE compositions of strawberry cv. Fern." Plant, Soil and Environment 51, No. 6 (November 19, 2011): 283–87. http://dx.doi.org/10.17221/3587-pse.

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Allelopathic effects of juglone and walnut leaf extracts from Persian walnut (Juglans regia L.) on yield, growth, chemical and plant nutrient element composition of the day-neutral strawberry (Fragaria × ananassa L.) cultivar Fern were investigated as part of an effort to identify tolerant species to plant adjacent to walnut. Strawberry plants were treated with juglone (5-hydroxy-1.4 naphthoquinone, 1mM) and walnut leaf extracts (undiluted, 1/2, 1/4, 1/8 diluted). Vegetative and reproductive plant growth was inhibited strongly by the treatment of both juglone and undiluted walnut leaf extracts. Fruit yield per plant, the number of fruit per plant, average fruit weight, crowns per plant, number of leaves, leaf area, fresh root weight, total soluble solid (TSS), vitamin C and acidity were reduced by juglone treatment compared to the control. All nutrient elements analyzed in the leaves generally were lower than the control for all treatments except 1/8 diluted.
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Khristyuk, A. V., and G. I. Kasyanov. "Prospects of creation of alcohol-free drinks on light water." Proceedings of the Voronezh State University of Engineering Technologies 80, no. 4 (March 21, 2019): 229–33. http://dx.doi.org/10.20914/2310-1202-2018-4-229-233.

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The article analyzes the prospects of creating non-alcoholic tonic drinks on light water. The aim of the work is to study the properties of water with a low content of deuterium for the production of beverages. A block diagram of the production of soft drinks using as a basic component of light water, watermelon juice concentrate as a sweetener, the use of natural preservative juglona, from the pericarp walnut. The theoretical prerequisites for a large-scale transition to the production of tonic drinks based on extracts from domestic herbs and light water are formulated. For the first time the formula composition of drinks with adaptogenic properties differing in antioxidant properties is developed. The range of adaptogenic drinks, which include light water and non-traditional spicy and aromatic raw materials, was systematized, which was the justification for the proposal to use antioxidants as identifiers of the authenticity of a new group of drinks. First proposed version of the graphical visualization of the target system for the formation of flavouring spicy-aromatic characteristics of several formulations of drinks, the algorithm of modeling of the prescription of drinks with light water with a savory and spicy taste. The performed studies have practical significance and have been tested in the production conditions of the Branch № 1 of the Moscow beer and non-alcoholic plant "Ochakovo". The original formulations of tonic drinks with adaptogenic properties are designed, the permissible terms of their storage are determined. The necessary documentation for the production of beverages based on light water and aromatic raw materials has been developed. Developed draft technical specifications for the drinks: "Drink for Rugby players", "players Drink", "Drink Chess". The conclusion is made about the expediency of pilot testing of the developed technology of beverage production.
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Paudel, Prajwal, Prabodh Satyal, Noura S. Dosoky, Samjhana Maharjan, and William N. Setzer. "Juglans Regia and J. nigra, Two Trees Important in Traditional Medicine: A Comparison of Leaf Essential Oil Compositions and Biological Activities." Natural Product Communications 8, no. 10 (October 2013): 1934578X1300801. http://dx.doi.org/10.1177/1934578x1300801038.

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The essential oils from the leaves of Juglans regia, collected from Kathmandu, Nepal, and Juglans nigra from Huntsville, Alabama, USA, were obtained by hydrodistillation and analyzed by GC-MS. A total of 69 compounds were identified in the J. regia oil, accounting for 99.0% of the eluting components of the oil while three different samples of J. nigra were analyzed identifying a total of 99.3%, 99.4% and 99.7% of the oils. The leaf essential oil of J. regia was dominated by the aromatic compounds eugenol (27.5%) and methyl salicylate (16.2%), and the sesquiterpenes germacrene D (21.4%) and ( E)-β-farnesene (8.2%). The essential oils from three different samples of J. nigra contained ( E)-caryophyllene (17.3%–20.4%) and germacrene D (7.1%–22.5%) with smaller amounts of juglone (1.0%–8.8%), α-hydrojuglone (1.0–9.5%), and δ-cadinene (3.8%–8.7%). J. regia leaf oil, devoid of juglone, showed allelopathic activity, while J. nigra leaf oil was less phytotoxic. The presence of eugenol and methyl salicylate in the leaves of J. regia are consistent with the traditional uses of this plant to treat toothache, rheumatism, and fungal infections.
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Dissertations / Theses on the topic "Juglona"

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Peleckytė, Urtė. "Homeopatiškai paruošti preparatai iš Juglans nigra L. kevalo: biologiškai aktyvių junginių analizė ir antioksidacinio aktyvumo tyrimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140701_144628-19868.

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Homeopatiniais vadinami preparatai, kurie yra pagaminti iš homeopatinių žaliavų, naudojant homeopatinės gamybos procedūras. Biologiniam homeopatinių preparatų aktyvumui tirti mokslininkai naudoja tuos pačius tyrimų metodus, kaip ir kitų rūšių cheminiams preparatams [32]. Šiam tyrimui pasirinkta homeopatinė juodojo riešuto (Juglans nigra L.) kevalo tinktūra ir jos D1 bei C1 praskiedimai – tai nedidelio laipsnio skiediniai, kuriuose veikliąsias medžiagas dar galima įdentifikuoti ir koncentracijas bei biologinį aktyvumą vertinti turimais tyrimo metodais. Mokslinės literatūros šaltiniuose skelbiama, jog juodojo riešuto kevale yra devynios pagrindinės cheminės medžiagos [29]. Nustatyta, jog riešuto viena iš pagrindinių veikliųjų medžagų yra juglonas, kuris turi citotoksinių savybių prieš melonomos, kepenų, plaučių, širdies, kraujo ląsteles [25,28,38,39]. Kadangi mokslinių tyrimų su preparatais, pagamintais iš juodojo riešuto, atlikta nedaug, todėl buvo pasirinkta ištirti polifenolinių junginių, juglono kiekį pagamintuose tirpaluose bei nustatyti jų antioksidacines savybes. Darbo tikslas: Homeopatiškai paruošti iš juodojo riešuto kevalo pradinę tinktūrą ir jos D1 bei C1 praskiedimus, ištirti polifenolinių junginių, juglono kiekį ir įvertinti antioksidantinį aktyvumą. Metodai: Pagaminta pradinė homeopatinė tinktūra (urtinktūra) ir jos skiediniai pagal Homeopatijos farmakopėjos reikalavimus (HAB 2000, 3a taisyklė). Spektrofotometriškai nustatytas polifenolinių junginių... [toliau žr. visą tekstą]
Preparations referred to as homoeopathic are those made of homoeopathic raw materials using homoeopathic manufacturing procedures. In order to measure biological activity of homoeopathic preparations scientists use the same investigation methods as with other kinds of chemical products [30]. For this study homoeopathic tincture of black walnut (Juglans nigra L.) shell and its D1and C1 dilutions have been selected as these produce low-grade solutions in which active substances still can be identified and concentrations as well as bioactivity can be assessed by available methods of testing. The scientific literature sources state that the black walnut shell contains nine basic chemical substances [29]. It is found that one of the basic active ingredients is juglone which possesses cytotoxic properties effective against melanoma, the liver, lung, heart and blood cells. [25,28,38,39]. As the studies of black walnut preparations are not so common, we have chosen to investigate the juglone amount and polyphenolic compounds in solutions and to measure their antioxidant properties. The aim of the research: To produce homoeopathically original tincture of the black walnut shell and its D1 and C1 dilutions, to explore polyphenolic compounds, the level of juglone and evaluate their antioxidant activity. The methodology: Original homoeopathic tincture (urtincture) and its solutions were produced following the specification of Homoeopathy Pharmacopoeia (HAB 2000, rule 3a)... [to full text]
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GILLES, V. "Síntese de novos inibidores COMBO naftoquinônicos não-poliméricos para indústria do petróleo." Universidade Federal do Espírito Santo, 2014. http://repositorio.ufes.br/handle/10/4716.

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Diversos problemas são encontrados durante as fases de produção e refino de petróleo. Devido à grande diversidade de condições de temperatura e pressão sob as quais os óleos crus são submetidos, não é incomum que alterações na solubilidade das substâncias ali presentes causem a precipitação de compostos orgânicos, em especial parafinas de alto peso molecular. Dentre as principais técnicas de remedição frente a precipitação encontra-se o uso de inibidores químicos. Estes apresentam a vantagem de serem facilmente aplicados nas linhas, acrescidos ao baixo custo. No presente trabalho foram sintetizados dez novos inibidores químicos de deposição de parafinas derivados da juglona (5-hidroxi-1,4-naftquinona) e da lausona (2-hidroxi-1,4-naftoquinona) funcionalizados como ésteres de ácidos graxos. Foi realizado um estudo metodológico para obtenção de três ésteres diretos da juglona (32a-c). Esses ésteres foram preparados segundo metodologia de Steglich modificada com rendimentos de 50 a 54 %, resultados significativamente maiores ao reportados anteriormente na literatura. Os ésteres derivados da lausona (33a-e, 56 e 60) foram obtidos após adição de uma cadeia lateral espaçadora com excelentes rendimentos, maiores que 90% para a etapa de esterificação. Posteriormente, os produtos foram avaliados como inibidores de precipitação pela alteração da TIAC via ensaios calorimétricos e por Ponto de Fluidez segundo a ASTM D5853. Foi realizado o estudo de concentração ótima que evidenciou 200 ppm como a mais eficiente. Os inibidores derivados da lausona foram testados quanto a redução da TIAC e do ponto de fluidez em dois óleos crus onde os produtos 33c e 33d, derivados dos ácidos palmítico e esteárico, destacaram-se com os melhores resultados nas duas propriedades, superando também um inibidor comercial aplicado nas mesmas condições (controle positivo). Avaliou-se o tamanho da cadeia lateral na redução do ponto de fluidez e foi observado que o aumento de 2 para 5 carbonos diminui a eficiência do inibidor no óleo testado. Foi também estudado o tipo do heteroátomo na união da cadeia lateral com o anel naftoquinônicos e concluiu-se que o composto com nitrogênio é mais eficiente do que o que contém enxofre.
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Kviecinski, Maicon Roberto. "Atividade antitumoral de extratos de bidens pilosa linné ricos em poliacetilenos e de juglona associada ao ascorbato." reponame:Repositório Institucional da UFSC, 2013. https://repositorio.ufsc.br/handle/123456789/106886.

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Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2013
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Introdução. Bidens pilosa L. é uma planta considerada medicinal que contém poliacetilenos presumivelmente responsáveis por ações antitumorais. As quinonas, como a juglona, também compreendem uma classe de substâncias de interesse por seu potencial antitumoral. Além disto, evidências indicam que a associação de ascorbato com algumas quinonas pode potencializar a atividade antitumoral. Objetivos. Avaliar o efeito antitumoral do extrato de B.pilosa obtido pela tecnologia supercrítica, a fim de obter um extrato rico em poliacetilenos (SFE) com atividade superior em comparação ao extrato obtido por maceração hidroetanólica (HCE). Testar a administração de juglona isoladamente ou em associação ao ascorbato em células T24 pela citotoxicidade; caracterizado o mecanismo de morte celular induzido, indução de estresse oxidativo, efeito antiproliferativo e preliminarmente, anti-invasivo in vitro. Por fim, avaliar a administração de juglona e ascorbato em associação a quimioterápicos convencionais, doxorrubicina e cisplatina. Metodologia. A composição fitoquimica dos extratos foi avaliada por cromatografia em camada delgada e espectrofotometria UV-Vis. A citotoxicidade para células MCF-7 e T24 foi avaliada pelo ensaio do MTT. O potencial lesivo sobre o DNA foi avaliado in vitro pela motilidade eletroforética de DNA plasmidial e imunoeletroforese para fosforilação da histona gama-H2Ax em células T24. Foram avaliados marcadores de danos oxidativos, geração celular de EROs e conteúdo de GSH, também a fosforilação do fator de iniciação eucariótico 2 eIF2a. Foi avaliada a morfologia das células em processo de morte, sendo também verificada a ativação de caspases por espectrofluorimetria e clivagem da poli (ADP-ribose) polimerase (PARP) por imunoeletroforese. A atividade antiproliferativa foi medida pelo ensaio de formação de colônias. A inibição da motilidade celular foi investigada pelo ensaio de migração. A atividade antitumoral in vivo foi medida em camundongos Balb-c portadores de tumor ascítico de Ehrlich. Resultados. Os espectros sobre os constituintes majoritários de SFE apresentaram bandas típicas de poliacetilenos com picos de absorção na faixa do UV registrados em 208, 269 e 334 nm. A citotoxicidade in vitro foi dependente da concentração dos extratos. Às 24h, a CI50 foi 811 e 437 µg/mL, respectivamente para HCE e SFE, reduzindo para 291 µg/mL às 48h, no caso de SFE. Às 24h, a CI50 foi 28,5 µM para juglona, reduzindo para 6,3 µM, quando associada ao ascorbato 1 mM. A citotoxicidade da cisplatina chegou a dobrar devida sua associação com juglona e ascorbato. HCE causou danos no DNA em 160 µg/mL, ao passo que 40 µg/mL de SFE causaram danos equivalentes. Juglona iniciou danos sobre o DNA em 20 µM, ao passo que 5 µM associados ao ascorbato 1 mM causaram danos equivalentes. A juglona induziu à geração celular de EROs e consumo de GSH; iniciando fosforilação do eIF2a que indica estresse de retículo endoplasmático. Estes efeitos foram potencializados em até 4 vezes pela associação ao ascorbato. A juglona sozinha ou associada ao ascorbato não causou ativação de caspases; corroborando a morfologia das células T24 em processo de morte, o processo induzido provavelmente está mais relacionado à necrose. Em tratamentos subletais, a juglona diminuiu a proliferação e a motilidade de células T24, ambos os processos potencializados pela associação ao ascorbato, que induziu à morte clonogênica. Finalmente, os ensaios in vivo indicaram que ambos os extratos de B. pilosa apresentaram atividade, mas SFE causou redução superior do volume de líquido ascítico e células compactadas (4 ± 1 e 1 ± 0,4 mL, respectivamente), ao mesmo tempo em que resultou em maior aumento no tempo de sobrevida (~31%) em comparação aos animais do controle negativo. A inibição do crescimento tumoral determinada para HCE foi de cerca de 40%, ao passo que esta determinação ultrapassou 60% no caso de SFE. Conclusão. A extração com fluido de CO2 supercrítico é uma alternativa para a obtenção de um extrato de B. pilosa rico em poliacetilenos citotóxicos com atividade antitumoral superior em comparação ao extrato obtido por maceração hidroetanólica. O ascorbato potencializa a citotoxicidade, o efeito antiproliferativo e inibidor da motilidade de células T24 in vitro da juglona. Os achados deste trabalho levam a sugerir que a dose do tratamento feito com juglona pode ser ajustada, em termos de redução da mesma, em até 4 vezes, se a juglona for administrada em associação ao ascorbato.

Abstract: Introduction. Bidens pilosa L. is a plant considered medicinal containing polyacetylenes expected to be responsible for antitumor actions. Quinones, such as juglone, comprise a class of substances of interest also due to their antitumor potential. Furthermore, evidences indicate that the combination of ascorbate with some quinones can result in potentiated antitumor activity. Objectives. The supercritical technology was assessed to obtain an extract from B.pilosa rich in polyacetylenes (SFE) with superior antitumor activity compared to that of the extract obtained by hydroethanol maceration (HCE). Juglone was tested administered alone and/or combined with ascorbate on T24 cells for cytotoxicity, the mechanism of cell demise was characterized, oxidative stress induction; antiproliferative and, preliminarily, anti-invasive effects. Juglone and ascorbate were evaluated for the cytotoxicity in combination with the conventional chemotherapics doxorubicin and cisplatin. Methodology. The phytochemical composition of extracts was evaluated by thin layer chromatography with UV-Vis spectroscopy. Cytotoxicity on MCF-7 and T24 cells was checked by the MTT assay. The damaging potential on DNA was assessed in vitro by the electrophoretic motility of plasmid DNA and immunoelectrophoresis for phosphorylation of histone gamma-H2Ax in T24 cells. Markers of oxidative stress, ROS generation and GSH consumption, and the phosphorylation of the eukaryotic initiation factor eIF2á were analyzed as well. The induced cell death process was monitored by caspase activation through spectrofluorimetry and poly (ADP-ribose) polymerase (PARP) cleavage by immunoelectrophoresis. The antiproliferativo action was measured by the colony forming assay. Cell motility inhibition was investigated by a migration assay. In vivo antitumor activity was measured in Ehrlich carcinoma-bearing Balb-c mice. Results. Spectra about the major constituents in SFE presented typical bands of polyacetylenes recorded in UV at 208, 269 and 334 nm. Cytotoxicity in vitro was concentration-dependent. At 24 h, IC50 was 811 and 437 ìg/mL, respectively for HCE and SFE on MCF-7 cells, falling to 291 ìg/mL at 48 h, in the case of SFE. At 24h, IC50 was 28.5 ìM for juglone on T24 cells, falling to 6.3 ìM when it was combined with ascorbate 1 mM. At 24 h, the cisplatin#s cytoxicity on T24 cells increased up to 2-fold due to its combination with juglone and ascorbate. HCE caused DNA damage at 160 ìg/mL, whereas SFE at 40 ìg/mL caused equivalent damage. Juglone triggered DNA damage at 20 ìM, whereas 5 ìM in combination with ascorbate 1 mM caused equivalent damage. Juglone caused reduction in terms of ROS generation and increased GSH consumption, triggering eiF2á phosphorylation that indicates endoplasmic reticulum stress. These actions were potentiated up to 4-fold due to the combination of juglone with ascorbate. Juglone alone or combined with ascorbate did not cause caspase activation, corroborating T24 cell morphology under demise, the induced cell death process seems to be close related to necrosis. Under sublethal treatments, juglone reduced the proliferation and the motility of T24 cells, both actions were potentiated due to the combination with ascorbate, something that finally induced to clonogenic cell death. In vivo assays indicated that both extracts from B. pilosa had activity, but SFE caused superior reduction in terms of ascitic fluid volume and packed cells (4 ± 1 e 1 ± 0.4 mL, respectively). Furthermore, SFE increased more the animals life span (~31%) compared to animals from the negative control. The tumor growth inhibition by HCE was about 40%, whereas more than 60% was reached by SFE. Conclusion. Supercritical extraction with fluid CO2 is a choice to obtain an extract from B. pilosa rich in cytotoxic polyacetylenes with superior antitumor activity in comparison to that of the extract obtained by hydroethanol maceration. Ascorbate potentiated the cytotoxicity, the antiproliferative action and the inhibition of T24 cells motility in vitro by juglone. These findings lead to suggest that the dose of the treatment done with juglone can be adjusted, in terms of reduction, up to 4-fold, if juglone is administered in combination with ascorbate.
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Nunes, Ana Filipa Pereira. "Desenvolvimento da síntese de possíveis indutores da glicoproteína-P." Master's thesis, Faculdade de Ciências e Tecnologia, 2012. http://hdl.handle.net/10362/8542.

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Dissertação para obtenção do Grau de Mestre em Mestrado em Bioorgânica
Neste trabalho foram sintetizados os compostos 7-metil-juglona e emodina, e respectivos derivados, utilizando uma abordagem de reacção de Diels-Alder. Para a obtenção dos compostos referidos, sintetizou-se e optimizou-se o processo de obtenção dos dienos necessários. O dieno de Danishesfky (η = 84%) foi utilizado como material de partida na síntese da 7-metil-juglona. Para obter o dieno de Brassard (η = 92%), material de partida na síntese do emodina, sintetizou-se primariamente o seu percursor metil β-metoxi-etanonato (η = 97%). A obtenção do composta 7-metil-juglona (η = 61 %) e do seu derivado metoxilado (η = 52 %) foi bem-sucedida, procedendo-se a diversas optimizações ao processo de síntese. A síntese do derivado metoxilado da emodina (η = 14%) também foi efectuada. Na conversão do derivado metoxilado da 7 metil juglona em emodina antrona obteve-se além composto previsto (η = 15%) o seu derivado monometoxilado (η = 43%). As tentativas de glicosilação da 7-metil-juglona, do seu derivado e da emodina, com 4-tetraacetato-1-bromo-α-D-glucosee 5-pentaacetato-β-D-glucose não foram bem sucedidas até à data.
Fundação para a Ciência e Tecnologia - (projecto PTDC/SAU-OSM/101437/2008)
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Rucký, Jakub. "Fytotoxicita vybraných naftochinonů na vybraném rostlinném modelu." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2013. http://www.nusl.cz/ntk/nusl-220020.

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The introductory part of this thesis is focused on the theoretical analysis of solved problems as examining the toxicity of naphthoquinones plumbagine and juglone, especially with regard to their allelopatic action. The next section is focuses on the plant stress, caused by the action of stress factors leading to their death. There is an experimental protocol and the possibilities of determination the effect of naphthoquinones on the plant model. Experimental section discusses changing growth parameters of the plant samples in different concentrations of the naphthoquinone. There is examined cell viability and changes in the synthesis of the secondary metabolites. Data obtained by using spectrophotometric and microscopic analysis are evaluated with STATISTICA software and statistical significance are plotted.
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Keturakytė, Vytautė. "Skystųjų preparatų iš Juglans nigra L. lapų gamyba, biologiškai aktyvių junginių kiekio įvertinimas ir antioksidacinio aktyvumo tyrimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140618_215819-93554.

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Tyrimo tikslas - pagaminti vandenines ir etanolines ištraukas iš Junglans nigra L. lapų ir įvertinti bendrą fenolinių junginių, bendrą flavonoidų, juglono kiekį bei nustatyti antioksidacinį aktyvumą. Metodika: 1. Tyrimo objektai: 70% etanolinė juodojo riešutmedžio tinktūra, vandeninė juodojo riešutmedžio lapų ištrauka bei gamyklinis “Black Walnut” 1:1 ekstraktas (gamintojas „Nature's Answer”, JAV). 2. Ištraukų iš J. nigra lapų gamyba. 1) Etanolinės tinktūros gamyba. Pritaikius perkoliacijos metodą iš juodojo riešutmedžio lapų žaliavos, naudojant 70% etanolį, buvo pagaminta tinktūra (santykis 1:10). 2) Vandeninė ištrauka. 10 g smulkintos lapų žaliavos buvo užpilta 120 ml verdančio vandens ir kaitinta 1 val. Ištrauka nufiltruota pro 4 nr. Vatmano filtrą. 3. Kokybinės flavonoidų įvertinimo reakcijos. 4. Bendras fenolinių junginių nustatymas naudojant Folin – Ciocalteu metodą (standartas – galo r.) 5. Bendras flavonoidų kiekio nustatymas spektrofotometriniu būdu, naudojant AlCl3 tirpalą (standartas - rutinas). 6. Juglono kiekio nustatymas spektrofotometriniu būdu. 7. Antioksidacinio aktyvumo įvertinimas fluorimetriniu būdu, naudojant 10-acetil-3,7-dihidroksifenoksazinas (AMR) ir krienų peroksidazę (HPR). Rezultatai. Bendram fenolinių junginių, bendram flavonoidų bei juglono išekstrahuoto kiekio palyginimui buvo pagamintos J. nigra lapų etanolinė ir vandeninė ištraukos. Tiriamų objektų biologiškai aktyvių komponentų kiekiai buvo palyginti su gamykliniu „Black Walnut“ ekstraktu... [toliau žr. visą tekstą]
Aim of the work - produce aqueous and ethanolic extracts of Junglans nigra leaves, evaluate the total phenolic and total flavonoids content, juglone concentration and identify antioxidant activity. Methods: 1. Objects of study: ethanolic tincture and aqueous extract of black walnut leaves, “Black Walnut” extract, 1:1 („Nature's Answer”, USA). 2. Liquid preparations of J. nigra leaves production: 1) Ethanolic tincture production. Tincture was produced of black walnut leaves applying the method of percolation. The 70% ethanol was used. Tincture ratio is 1:10. 2) Aqueous exract production. 10 g shredded leaves of black walnut were extracted with 120 ml of boiling wather for 1 hours. After boiling extract was filtered throught the Whatman paper no. 4. 3. Qualitative evaluation of flavonoids. 4. Total phenolic content was determined by spectrophotometric (Folin - Ciocalteau) method. 5. Total flavonoids content was measured with an aluminum chloride colorimetric assay using spectrophotometer. 6. Juglone determination by spectrophotometric method. 7. Fluorimetric antioxidant activity assay by using N-Acetyl-3,7-dihydroxyphenoxazine (Amplex Red) and horseradish peroxidase (HPR). Results. Ethanolic and aqueous extracts of J. nigra leaves were made to compare total phenolic, total flavonoids content, juglone concentration. Biologically active components study results of ethanolic and aqueous extracts were compared with “Black Walnut” extract. The highest total phenolic and total... [to full text]
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Costa, Cícero de Oliveira. "Estudos bioeletroquímicos de quinonas." Universidade Federal de Alagoas, 2011. http://www.repositorio.ufal.br/handle/riufal/2238.

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Many quinones have been associated with a wide range of biological activities, including antitumoral, antimalarial, larvicidal and antibacterial activities. Although, there are many clinically important agents containing a quinone nucleus with excellent anticancer activity, many other quinones require testing for additional activities, for instance: Oncocalyxone A, Juglone, Biflorin and some hydroxylated and halogenated quinones. DNA represents one of the main targets of biologically active quinonoid compounds, which, generally, belong to the group of DNA intercalating and/or alkylating agents, and/or topoisomerase inhibitors. As such, the use of DNA biosensors or other electrochemical methods based on the investigation of nucleic acid/organic compound interaction, would allow to predicting a biological action, if this one is related to damage to DNA. Due to the importance of quinones, for instance, Oncocalyxone A, Juglone and Biflorin, electrochemical analysis and the development of a new electroanalytical method for detection in nanomolar quantities, together with DNA interaction analysis with those quinones was therein performed. We have used diverse electrochemical methods performed in protic and aprotic media, using glassy carbon electrode, Ag/AgCl electrode as reference and latinum wire as counter electrode. The pKa of juglone was determined (5.98). The development of a highly sensitive voltammetric sensor for oncocalyxone A using a glassy carbon electrode modified with a bilayer iron(II) tetrasulfonated phthalocyanine (FeTSPc) and iron(III) tetra-(N-methyl-4-pyridyl)-porphyrin (FeT4MPyP) was described. The modified electrode showed catalytic activity and stability for the oncocalyxone A reduction, provoking the anodic shift of the reduction peak potentials of ca. 30 mV and presenting much higher peak currents than those obtained on the bare GC electrode. A wide linear response range between 0.005-1.210-6 mol L-1, with a sensitivity of 8.11 μA L μmol-1 and limits of detection (LOD) and quantification (LOQ) of 1.5 and 5.010-9 mol L-1 were obtained with this sensor, respectively. The interaction of chosen quinones with ssDNA, poly-guanilic and poly-adenilic acid was investigated, using voltammetric analysis, in solution. The DNA interaction investigation with juglone, oncocalyxone and biflorin had shown significant DNA activity, represented by the decrease of oxidation current and shift of oxidation peaks of guanine and adenine and the binding constant values obtained for these aducts; these observations could be related to Michael addition reaction, among other possible effects. Some of the quinones do not cause any change on the oxidation peaks of the used bases, as is the case of -lapachone, being used as negative control. These results, upon comparison with biological/ pharmacological activities, show correlation and indicate electrochemistry and DNA sensors as important tools in the screening of biologically active compounds.
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Muitas quinonas têm sido associadas a uma grande variedade de atividades biológicas, incluindo atividades antitumorais, antimaláricas, larvicidas e antibacterianas. Embora existam muitos agentes clinicamente importantes contendo núcleo quinônico com excelente atividade anticâncer, muitas outras quinonas requerem testes para busca de atividades adicionais, como por exemplo: Oncocalixona A, Juglona, Biflorina e outras quinonas hidroxiladas e halogenadas. O DNA representa um dos principais alvos de compostos quinônicos, que, geralmente, pertencem aos grupos de intercaladores de DNA e/ou agentes alquilantes, e/ou inibidores de topoisomerases. Desta forma, o uso de biossensores de DNA ou outros métodos eletroquímicos baseados na investigação da interação entre ácidos nucléicos e compostos orgânicos, permitiria predizer a ação biológica, e se estas estão relacionadas aos danos ao DNA. Devido à importância das quinonas, entre elas, Oncocalixona A, Juglona e Biflorina, análises eletroquímicas e eletroanalíticas para detecção em quantidades nanomolares, bem como a investigação da interação destas quinonas com o DNA foram realizadas, no presente trabalho.Utilizou-se uma série de métodos eletroquímicos, em diferentes condições, em meios aprótico e prótico, usando eletrodo de carbono vítreo, como eletrodo de trabalho, Ag/AgCl, como eletrodo de referência e fio de platina, como contra-eletrodo. O pKa da juglona foi determinado (5,98). O desenvolvimento de um sensor voltamétrico altamente sensível para oncocalixona A, usando eletrodo de carbono vítreo modificado com uma bicamada de ftalocianina tetrassulfonada de ferro(II) (FeTSPc) e tetra-(N-metil- 4-piridil)-porfirina de ferro(III) (FeT4MPyP) foi descrito. O eletrodo modificado mostrou atividade catalítica e estabilidade para a redução da oncocalixona A, proporcionando o deslocamento anódico do potencial de pico de redução de ca. 30mV, apresentando correntes de pico maiores do que aquelas obtidas em eletrodo de carbono vítreo limpo. Uma faixa linear entre 0,005-1,210-6 mol L-1, com uma sensibilidade de 8,11 μA L μmol-1 e limites de detecção (LD) e quantificação (LQ) de 1,5 e 5,010-9 mol L-1 foram obtidos com este sensor, respectivamente. A interação das quinonas escolhidas com ssDNA, ácido poliguanílico e ácido poliadenílico foi investigada usando análises voltamétricas, em solução. Juglona, oncocalixona e biflorina mostraram forte interação em relação ao DNA, representado experimentalmente pela diminuição da corrente de oxidação e deslocamento dos picos diagnósticos de guanina e adenina, bem como pelos valores das constantes de associação calculadas para o aduto formado. Algumas das quinonas não causaram qualquer mudança nos picos de oxidação das bases usadas, como foi o caso da -lapachona, o que serviu como controle negativo, indispensável em relação a comparações com métodos farmacológicos. Estes resultados foram correlacionados positivamente com atividades biológicas/farmacológicas. Sensores de DNA são importantes ferramentas no mapeamento de compostos biologicamente ativos.
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Klimešová, Marie. "Elektroforetické a imunofluorescenční metody ve studiu rostlinných buněčných kultur." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2013. http://www.nusl.cz/ntk/nusl-220055.

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In all organisms are rising a reactive oxygen and nitrogen species by the effects of various stress factors and these species have a negative impact on the organism. Due to this species plants have built up an efficient antioxidant system, that helps them to resist negative effects of reactive oxygen and nitrogen species. In this work was researched the effect of hydrogen peroxide and sodium benzoate on the production of hydrogen peroxide, superoxide, reactive nitrogen species and malondialdehyde, contained in the root and above-ground part of maize (Zea mays L.). By use of the fluorescence microscopy there were obtained images of cross-cut of root from which was determined the intensity of fluorescence of individual parts of the root and was examined the effect of the intensity of fluorescence markers of oxidative stress in dependence on the type of the fluorescence filter used.
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Thakur, Ajay. "Genetic variation of Juglans regia L." Thesis, Bangor University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431492.

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Meynier, Véronique. "Propagation "in vitro" de noyers sélectionnés, Juglans regia, Juglans nigra x regia culture de noeuds, culture de méristèmes." Grenoble : ANRT, 1985. http://catalogue.bnf.fr/ark:/12148/cb375949653.

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Books on the topic "Juglona"

1

Shiva, M. P. Juglans regia: Walnut. Dehra Dun: Surya International Publication, 1998.

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Mozart i jugla. Beograd: Narodna knj. Alfa, 2004.

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Komanich, I. G. Otdalennai͡a︡ gibridizat͡s︡ii͡a︡ vidov orekha (Juglans L.). Kishinev: "Shtiint͡s︡a", 1989.

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Saadat, Yousef Ali. In Vitro Culture of Persian Walnut (Juglans Regia L.). Dublin: University College Dublin, 1998.

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Patmalnieks, Gundars. Mergupe, Suda, Lielā Jugla, Rīgas ūdensceļi. Rīga: Staburaga bērni, 2007.

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Bettancourt, E. J. Directory of germplasm collections.: Actinidia, Amelanchier, Carya, Castanea, Corylus, Cydonia, Diospyros, Fragaria, Juglans, Malus, Mespilus, Morus, Olea, Pistacia, Prunus, Punica, Pyrus, Ribes, Rosa, Sambucus, Sorbus, Vaccinium and others. Rome: International Board for Plant Genetic Resources, 1989.

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Steve, Burton, ed. Hocus pocus junior: The anatomie of legerdemain, or, the art of jugling set forth in his proper colours, fully, plainely, and exactly, so that an ignorant person may thereby learne the full perfection of the same, after a little practise. Cypress, Tex. (P.O. Box 238, Cypress 77410-0238): Steve Burton Magic, 1997.

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Book chapters on the topic "Juglona"

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Bährle-Rapp, Marina. "Juglon." In Springer Lexikon Kosmetik und Körperpflege, 292. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_5500.

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Woeste, Keith, and Charles Michler. "Juglans." In Wild Crop Relatives: Genomic and Breeding Resources, 77–88. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-21250-5_5.

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Schomburg, Dietmar, and Dörte Stephan. "Juglone 3-monooxygenase." In Enzyme Handbook, 841–44. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-57942-4_176.

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Bährle-Rapp, Marina. "Juglans regia." In Springer Lexikon Kosmetik und Körperpflege, 292. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_5499.

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Leslie, Charles A., Sriema L. Walawage, Sandra L. Uratsu, Gale McGranahan, and Abhaya M. Dandekar. "Walnut (Juglans)." In Methods in Molecular Biology, 229–41. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1658-0_19.

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Leslie, Charles A., Sandra L. Uratsu, Gale McGranahan, and Abhaya M. Dandekar. "Walnut (Juglans)." In Agrobacterium Protocols Volume 2, 297–307. Totowa, NJ: Humana Press, 2006. http://dx.doi.org/10.1385/1-59745-131-2:297.

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Lim, T. K. "Juglans regia." In Edible Medicinal And Non Medicinal Plants, 60–74. Dordrecht: Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-2534-8_4.

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Sastry, K. Subramanya, Bikash Mandal, John Hammond, S. W. Scott, and R. W. Briddon. "Juglans regia (Walnut)." In Encyclopedia of Plant Viruses and Viroids, 1301–2. New Delhi: Springer India, 2019. http://dx.doi.org/10.1007/978-81-322-3912-3_495.

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Khare, C. P. "Juglans regia Linn." In Indian Medicinal Plants, 1. New York, NY: Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-70638-2_836.

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Rodriguez, R., A. Revilla, M. Albuerne, and C. Perez. "Walnut (Juglans spp.)." In Trees II, 99–126. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-61535-1_7.

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Conference papers on the topic "Juglona"

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Meyer, George. "Investigating Resistance Mechanisms to the Natural Product-Based Herbicide Juglone." In ASPB PLANT BIOLOGY 2020. USA: ASPB, 2020. http://dx.doi.org/10.46678/pb.20.1063454.

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Ji, Yubin, Zhong Yuan Qu, Xiang Zou, Lan Cui, and Guo-Jun Hu. "Studies on Inhibition of Juglone on Sarcoma 180 in Mice." In 2009 3rd International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2009. http://dx.doi.org/10.1109/icbbe.2009.5163442.

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Silva, Wanderson A. da, Vinicius N. Moreira, Vinícius R. Campos, Vitor F. Ferreira, David R. da Rocha, Jackson A. L. C. Resende, Raquel C. Montenegro, Maria Cecília B. V. de Souza, and and Anna C. Cunha. "Synthesis of new naphthotriazoles derived from juglone as anticancer agents." In 15th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_201392591247.

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Schwindl, S., B. Kraus, and J. Heilmann. "Phytochemical study of Juglans regia L. leaves." In GA 2017 – Book of Abstracts. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1608208.

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Emelyanova, E. V., and I. P. Solyanikova. "STUDY OF THE EFFECT OF JUGLONE ON INTACT AND IMMOBILIZED MICROBIAL CELLS." In The All-Russian Scientific Conference with International Participation and Schools of Young Scientists "Mechanisms of resistance of plants and microorganisms to unfavorable environmental". SIPPB SB RAS, 2018. http://dx.doi.org/10.31255/978-5-94797-319-8-297-301.

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Ahmad, Taseer, ‪Taous‬ Khan, Abdul Shah, Tahira Tabassum, Sultan Almedhesh, Hamdan Al shehri Al, Alasmary Yahia, Mater Mahnashi, and Mohammed Alqahtani. "Cardioprotective effect of juglone on isoproterenol-induced myocardial injury in SD rats." In The 1st International E-Conference on Antioxidants in Health and Disease. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/cahd2020-08916.

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Sucman, Natalia, Timur Andrusenco, and Fliur Macaev. "Synthesis of hybrid molecules by interaction of 2-hydroxy juglone with terpenoid aldehydes." In New frontiers in natural product chemistry, scientific seminar with international participation. Institute of Chemistry, 2021. http://dx.doi.org/10.19261/nfnpc.2021.ab29.

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Зименкина, Н. И., and В. А. Куркин. "СРАВНИТЕЛЬНОЕ ФАРМАКОГНОСТИЧЕСКОЕ ИССЛЕДОВАНИЕ ЛИСТЬЕВ ПРЕДСТАВИТЕЛЕЙ РОДА ОРЕХ (JUGLANS L.)." In Современные тенденции развития технологий здоровьесбережения. Москва: Федеральное государственное бюджетное научное учреждение "Всероссийский научно-исследовательский институт лекарственных и ароматических растений", 2020. http://dx.doi.org/10.52101/9785870190921_2021_8_217.

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Ji, Yu bin, Zhong yuan Qu, Xiang Zou, and Lan Cui. "Effects of juglone on ROS production and mitochondrial transmembrane potential in SGC-7901 cells." In 2009 IEEE/ICME International Conference on Complex Medical Engineering - CME 2009. IEEE, 2009. http://dx.doi.org/10.1109/iccme.2009.4906587.

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Ji, Yubin, Zhongyuan Qu, Xiang Zou, and Chenfeng Ji. "Effects of Juglone on ROS Production and Mitochondrial Transmembrane Potential in SGC-7901 Cells." In 2010 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2010. http://dx.doi.org/10.1109/icbbe.2010.5517683.

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Reports on the topic "Juglona"

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Ostry, M. E., M. J. Moore, and S. A. N. Worrall. Butternut (Juglans cinerea) annotated bibliography. St. Paul, MN: U.S. Department of Agriculture, Forest Service, North Central Research Station, 2003. http://dx.doi.org/10.2737/nc-gtr-235.

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