Dissertations / Theses on the topic 'June 7'

"A fish out of water" is a figure of speech expressing incongruity. At first sight, "Fish farming in the desert" might seem to express a similar sense of dislocation, even futility. But, in fact, fish farming or aquaculture is attracting interest in Arizona. Its supporters, few in number but committed, believe that aquaculture, a field relatively new to the state, has the potential to become a viable Arizona industry.

Boston University. University Professors Program Senior theses.<br>PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>2031-01-02

Der Verein für Gerberei-Chemie und -Technik (VGCT) wurde 1949 zur Förderung wissenschaftlicher und technischer Forschung, zum Zwecke des fachlichen Erfahrungsaustausches sowie zur Förderung des beruflichen Nachwuchses gegründet. Gegenwärtig hat er ca. 300 Mitglieder, welche sowohl einzelne Personen als auch Firmen sind. Im VGCT treffen sich Ledertechniker, Maschinenbauer, Chemiker und andere am „Ledermachen“ interessierte Menschen zum Austausch und zu gemeinsamer Arbeit. Der Verein bietet eine Plattform für den fachlichen Austausch indem er jährliche Fachtagungen und fachliche Kooperationen in firmenübergreifenden Arbeitsgruppen (Kommissionen) organisiert, technische Veröffentlichungen in der Fachpresse mit eigenen Seiten fördert und sich aktiv an Umweltschutz, Arbeitssicherheit sowie Gesundheitsschutz beteiligt.<br>The Association for Chemistry and Technology in Tanning (VGCT) was founded in 1949 in order to facilitate scientifi c and technical research and exchange of professional experience as well as to promote young talents. Currently it has some 300 members – single persons as well as enterprises. In the VGCT, leather technologists, mechanical engineers, chemists and other people interested in “making leather” meet in order to exchange ideas and work together. The association offers a platform for sharing professional experience by organizing annual meetings and professional co-operations in groups from across various companies (commissions), by facilitating technical publications in specialist press with own pages and actively participating in environmental protection, occupational safety and health protection.

Interleukin-7 (IL-7) is an essential cytokine for lymphocyte growth that has the potential for promoting proliferation and survival. While the survival and proliferative functions of IL-7 are well established, the identities of IL-7 signaling components in pathways other than JAK/STAT, that accomplish these tasks remain poorly defined. To this end, we used IL-7 dependent T-cells to examine those components necessary for cell growth and survival. Our studies revealed two novel signal transducers of the IL-7 growth signal: BimL and JunD. IL-7 promoted the activity of JNK (Jun N-terminal Kinase), and that JNK, in turn, drove the expression of JunD, a component of the Activating Protein 1 (AP-1) transcription factors. Inhibition of JNK/JunD blocked glucose uptake and HXKII gene expression, indicating that this pathway was responsible for promoting HXKII expression. After a bioinformatics survey to reveal possible JunD-regulated genes activated early in the IL-7 signaling cascade, our search revealed that JunD could control the expression of proteins involved in signal transduction, cell survival and metabolism, including Pim-1. Pim-1, an IL-7 induced protein, was inhibited upon JNK or JunD inhibition. Our hypothesis that JunD positively regulated proliferation was confirmed when the proliferation of primary CD8+ T-cells cultured with IL-7 was impaired upon treatment with JunD siRNA. These results show that the IL-7 signal is more complex than the JAK/STAT pathway, activating JNK and JunD to induce rapid growth through the expression of metabolic factors like HXKII and Pim-1. When metabolic activities are inhibited, cells undergo autophagy, or cell scavenging, to provide essential nutrients. Pro-apoptotic Bim was evaluated for its involvement in autophagy. Bim is a BH3-only member of the Bcl-2 family that contributes to T-cell death. Partial rescue of T-cells occurs when Bim and the interleukin-7 receptor are deleted, implicating Bim in IL-7-deprived T-cell apoptosis. Alternative splicing results in three different isoforms: BimEL, BimL, and BimS. To study the effect of Bim deficiency and define the function of the major isoforms, Bim-containing and Bim-deficient T-cells, dependent on IL-7 for growth, were used. Loss of Bim in IL-7-deprived T-cells delayed apoptosis, but blocked the degradative phase of autophagy. The conversion of LC3-I to LC3-II was observed in Bim-deficient T-cells, but p62, which is degraded in autolysosomes, accumulated. To explain this, BimL, was found to support acidification of lysosomes associated with autophagic vesicles. Key findings showed that inhibition of lysosomal acidification accelerated death upon IL-7 withdrawal only in Bim-containing T-cells, indicating that in these cells autophagy was protective. IL-7 dependent T-cells lacking Bim were insensitive to inhibition of autophagy or lysosomal acidification. BimL co-immunoprecipitated with dynein and Lamp1-containing vesicles, indicating BimL could be an adaptor for dynein to facilitate loading of lysosomes. In Bim deficient T-cells, lysosome-tracking probes revealed vesicles of less acidic pH. Over-expression of BimL restored acidic vesicles in Bim deficient T-cells, while other isoforms, BimEL and BimS, associated with intrinsic cell death. These results reveal a novel role for BimL in lysosomal positioning that may be required for the formation of functional autolysosomes during autophagy.<br>ID: 031001292; System requirements: World Wide Web browser and PDF reader.; Mode of access: World Wide Web.; Error in paging: p. v followed by 1 unnumbered page and then followed by p. ii-vii.; Adviser: Annette R. Khaled.; Title from PDF title page (viewed March 1, 2013).; Thesis (Ph.D.)--University of Central Florida, 2012.; Includes bibliographical references (p. 99-121).<br>Ph.D.<br>Doctorate<br>Molecular Biology and Microbiology<br>Medicine<br>Biomedical Sciences

Made available in DSpace on 2014-12-17T15:32:16Z (GMT). No. of bitstreams: 1 DeborahPPI.pdf: 1504501 bytes, checksum: a7d060d1016a25d3b60f572c27bd03bc (MD5) Previous issue date: 2008-10-14<br>We investigated the immunohistochemistry expression of claudins -1 and -7 in ameloblastoma and in human dental germs on the pattern of distribution (focal, regional or diffuse), the cells that expressed (if central or peripheral) and the location of that expression in the cell components recital membrane, cytoplasm and nucleus. Among the 29 cases of ameloblastoma, 24 were type solid and 6 unicystic. In 7 mandibular specimens of human fetuses found dental germs from the stage of bud to the crown. We note that the pattern of expression in the dental germs was variable for claudinas studied according to the cell type and stage of differentiation and was invariate only in the cells of stellate reticulum. In epithelium internal of enamel organ, claudin-1 has been decreasing with the progression of differentiation as to claudina-7 that was found in the cells of the peripheral papilla. For ameloblastoma the expression was more significant than that observed in dental germs. Fisher s exact test no found association between the expression of claudinas cells in central and peripheral and the type of ameloblastoma (solid or unicystic). Thus, in general the claudin-1 was positive in the central cell of 93,1% of the cases and in peripheral cells of 51,7%. The claudin-7 was expressed in the cells of all cases central and peripheral cells from 89,7%. For both claudins the distribution was predominantly diffuse cells both in central and peripheral cells. Given our findings it is suggested that the expression of claudins may be indicative of the involvement of these molecules in morphogenetics events culminating with the dental development and that possibly influence the development of neoplastic ameloblastoma<br>Investigamos a express?o imuno-histoqu?mica das claudinas -1 e -7 em ameloblastomas e germes dentais humanos, avaliando o padr?o de distribui??o (focal, regional ou difuso), as c?lulas que as expressavam (central ou perif?rica) e a localiza??o dessa express?o nos constituintes celulares considerando membrana, citoplasma e n?cleo. Dentre os 29 casos de ameloblastomas, 23 eram do tipo s?lido e 6 unic?sticos. Nos 7 esp?cimes mandibulares de fetos humanos observamos germes dentais desde a fase de capuz at? a fase de coroa. Constatamos que o padr?o de express?o nos germes dentais foi vari?vel para as claudinas estudadas de acordo com o tipo celular e est?gio de diferencia??o assemelhando-se apenas nas c?lulas do ret?culo estrelado. No epit?lio interno a express?o da claudina-1 foi decrescente com a progress?o da diferencia??o enquanto para a claudina-7 foi verificada nas c?lulas perif?ricas da papila. Para os ameloblastomas, de forma geral, a express?o foi mais significativa do que aquela observada nos germes dentais. Foi aplicado o teste estat?stico de Fisher o qual n?o demonstrou associa??o entre a express?o das claudinas nas c?lulas centrais e perif?ricas e o tipo do ameloblastoma (s?lido ou unic?stico). De uma maneira geral, a claudina-1 foi positiva nas c?lulas centrais de 93,1% dos casos e nas c?lulas perif?ricas de 51,7%. A claudina-7 esteve expressa nas c?lulas centrais de todos os casos e nas c?lulas perif?ricas de 89,7%. Para ambas as claudinas a distribui??o foi predominantemente difusa tanto nas c?lulas centrais como nas c?lulas perif?ricas. Diante dos nossos achados sugere-se que a express?o das claudinas pode ser indicativa da participa??o destas mol?culas nos eventos morfogen?ticos que culminam com a forma??o dental e possivelmente influenciam o desenvolvimento neopl?sico dos ameloblastomas

This thesis is devoted to reveal the negative regulators in IGF-1 (Insulin like growth factor 1) stimulated growth of a human breast adenocarcinoma cell line. It is a well established fact that increased circulating levels of IGF-1 correlate with increased risk of breast cancer. IGF-1 activation of its receptor, IGF-1R, is implicated in the progression of breast cancer, where IGF-1 stimulation leads to proliferative and anti-apoptotic responses by stimulating MAPK Erk and PI3K, respectively. In this study, IGF-1 stimulated MCF-7 cells proliferated more in the absence of MAPK JNK, implicating the involvement of MAPK JNK in the negative regulation of IGF-1 stimulated cell growth. In this research study, we show for the first time that IGF-1 stimulation of breast cancer cells induces SHP-1-expression by activating JNK, which in turn, activates RFX-1 and AP-4 transcription factors to allow them to bind to the high-expression region of the SHP-1 P-1 promoter in breast adenocarcinoma MCF-7 cells. (Abstract shortened by UMI.)

Die Geräte, durch die Musik im Zeitalter der technischen (Re-)Produktion gehört wird, haben sich immer wieder gewandelt. Solche Geräte müssen überhört werden. Nur so kann Musik gehört werden. Trotzdem – so die These der Arbeit – organisieren diese Geräte das Hören und sind Agenturen einer Bewirtschaftung und Technisierung der Wahrnehmung. In der Arbeit wird anhand von zwei Fallstudien aus der Geschichte der Rock- und Popmusik gezeigt, wie solche Geräte sowohl den Hörer als auch die gehörte Musik formieren. Durch Hörtechnologien bilden sich neue Hörpraktiken heraus und die Körperlichkeit des Hörers wird neu bestimmt. Die Anpassung von Klanggeschehen an spezifische Hörtechnologien wird im Mastering – dem letzten Schritt der technischen Musikproduktion – untersuchbar. Die Geräte, durch die Musik gehört wird, sind also weder schlichte Wiedergabetechnologien noch bloße elektrotechnische Artefakte. Vielmehr sind sie Gefüge aus Klanglichkeit, Körperlichkeit und Technologie. Diese werden in der Arbeit als Hörgeräte auf den Begriff gebracht. Die Hörgeräte der Rock- und Popmusik zielen – wie ihre medizintechnischen Verwandten – auf die Materialität der Wahrnehmung. Im Gegensatz zu diesen funktionieren sie jedoch nicht als Prothesen, die an einer gattungsweit postulierten Norm ausgerichtet sind. Statt Normen bergen sie Exzesse – an Serialität und Wiederholung – sowie Eskalationen – von Lautstärke und von hohen und tiefen Frequenzen. Die Arbeit ist in drei Kapiteln gegliedert. Im ersten Kapitel wird die These der Arbeit in Bezug auf theoretische Diskurse der Musik-, Kultur- und Medienwissenschaft verortet und eine begriffliche Systematik entwickelt. Kapitel zwei und drei sind Fallstudien gewidmet. In der ersten wird das Jukeboxhören der Rock’n’Roll-Kultur der 1950er Jahre untersucht, in der zweiten das Soundsystemhören der Disco- und Clubkultur der 1970er bis 1990er Jahre. Die im ersten Kapitel entwickelte begriffliche Systematik macht die Fallstudien vergleichbar.<br>The devices by which music is listened to in the age of technological (re-)production have changed over and over again. These devices must be imperceptible to the ear. Only then can music be heard. Nonetheless – this is the claim of the thesis – these devices organize hearing and are agents of a cultivation and technization of perception. Based on two case studies from the history of rock and pop music, this thesis reveals how such devices constitute not only the listener but also the music which is listened to. Through listening technologies new listening practices emerge and the corporality of the listener is newly defined. The adaptation of sound to specific listening technologies can be analysed during the mastering process, the last step in technological music production. The devices by which music is listened to are thus neither simple technologies of reproduction nor mere electrotechnical artefacts. Rather, they are assemblages of sound, corporality, and technology. In this thesis these assemblages are called “Hörgeräte” (listening devices). The listening devices of rock and pop music target – like medical-technical “Hörgeräte” (hearing aids) – the materiality of perception. Contrary to medical technologies, however, listening devices do not function as prostheses, which are calibrated according to medical industry standards. Instead, they contain excesses – of seriality and repetition – and escalations – of amplitude and high and low frequencies. The thesis is arranged in three chapters. In the first chapter I situate the main argument of the thesis within discourses of musicology, media and cultural studies, and develop my own terminology. Chapters two and three deal with case studies. In chapter two I investigate jukebox listening in 1950s rock’n’roll culture, whilst in chapter three I explore sound system listening in disco and club culture from the 1970s to the 1990s. The terminology developed in chapter one enables a comparison of the case studies.

On June 7, 1994, an Ad Hoc team from LAI visited John Deere to conduct an informal benchmark of John Deere's successful change to Leaner Manufacturing. This report summarizes the results of that trip, as well as summarizing lessons for the aerospace industry.<br>Lean Aerospace Initiative