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Journal articles on the topic 'Jute mutants'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Khan, MMH. "Evaluation of Different Mutants Against Insect and Mite Pests With Natural Enemies in Coastal Jute Ecosystem." Journal of the Asiatic Society of Bangladesh, Science 44, no. 1 (2018): 23–33. http://dx.doi.org/10.3329/jasbs.v44i1.46543.

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Jute is a rapid growing agricultural fiber crop and renewable source of biomass. The study was conducted to evaluate different jute mutants against insect and mite pests with associated natural enemies. Results revealed that 8 insect and mite pests and 8 natural enemies were recorded from coastal jute ecosystem. Jute hairy caterpillar and yellow mite were found to be the most damaging pests in jute field. Significantly the lowest per cent plant infestation per 5 rows was recorded in mutant BJC-214 (14.37) followed by BJC-7370 (14.81) and the highest per cent plant infestation (30.77) was found

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Md., Robiul Islam Akondo, Belal Hossain Md., Sefaur Rahman Md., Shamiul Haque Md., and Abul Kalam Azad Md. "Screening of suitable tossa jute (Corchorus olitorius L.) mutant to increase fiber production." GSC Biological and Pharmaceutical Sciences 10, no. 2 (2020): 099–105. https://doi.org/10.5281/zenodo.4280530.

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The present study was conducted at the research farm of Bangladesh Institute of Nuclear Agriculture (BINA) Sub-station, Gopalganj, to find out the effective mutant for increasing fiber production of jute during March – September 2019. Mutant lines (JRO-1000-8, JRO-1000-10, JRO-700-3, JRO-1000-9) and two check varieties (JRO-524, BJRI-8) were used in this study. The experimental design was a randomized completely block with three replications. Morphological characters, plant height and base diameter were studied for the screening of jute mutants for higher yield. Results indicated that th

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3

Sakina Khanam, Md Shamiul Haque, Md Mahmud Al Noor, Nusrat Binta Atiq, and Md Abul Kalam Azad. "Development of Two Tossa Jute Mutants for Higher Fiber Yield Through Mutation Breeding." Research in Agriculture Livestock and Fisheries 10, no. 3 (2024): 259–68. http://dx.doi.org/10.3329/ralf.v10i3.70992.

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The demand for jute fiber is increasing instead of synthetic fiber nowadays. Developing an early and high fiber-yielding tossa jute line is the main breeding objective of jute growing areas including Bangladesh. To fulfill that objective, the existing cultivar JRO-524 was irradiated with five (700, 800, 900, and 1000 gy) doses of gamma-ray. A total of 25 M3 plants were first selected from bulked M2 plants. Two years of replicated yield trial experiments were conducted in different locations in Bangladesh. Among them, two mutants BJM-10-1-3 and BJM-10-1-5 were selected for higher fiber and stic

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4

Mandal, Aninda. "New Plant Type Mutants in Jute (Corchorus olitorius L.)." Indian Journal of Science and Technology 4, no. 5 (2014): 543–53. http://dx.doi.org/10.17485/ijst/2014/v7i5.1.

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5

Islam, M. N., A. T. M. Hasanuzzam, M. Mofazzel H, and A. T. M. F. Islam. "Response of Radiation Induced Jute (Corchorus olitorius L.) Mutants Against Jute Stem Weevil, Apion corchori Marshall." Pakistan Journal of Biological Sciences 5, no. 11 (2002): 1173–75. http://dx.doi.org/10.3923/pjbs.2002.1173.1175.

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6

Shamsuzzaman, K. M., R. N. Oram, K. Malafant, M. A. Q. Shaikh, A. D. Bhuiya, and R. K. Dutta. "Fibre yiedl of mutants of white jute (Corchorus capsularis) with altered phenological development patterns." Field Crops Research 18, no. 2-3 (1988): 101–11. http://dx.doi.org/10.1016/0378-4290(88)90002-0.

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Shruti, Banswal Aqbal Singh. "TEM STUDIES OF NODULES ELICITED BY SINORHIZOBIUM MELILOTI PLEIOTROPIC MUTANT DEFECTIVE IN EXOPOLYSACCHARIDE SYNTHESIS." International Journal of Life Sciences Research 12, no. 2 (2024): 46–55. https://doi.org/10.5281/zenodo.12581081.

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<strong>Abstract:</strong> Five purine auxotrophic mutants of <em>Sinorhizobium meliloti</em> strain Rmd 201(WT) were isolated using NTG mutagenesis. Mutants elicited white, small, spherical, determinate, and Fix<sup>- </sup>pseudonodules on <em>Medicago sativa</em>. These nodules lacked bacteroids and one mutant Rmd 1102(A<sub>2</sub>) exhibited Exo<sup>-</sup> phenotype due to production of defective exopolysaccharide, particularly lacking xylose sugar. Cross feeding with xylose as sole carbon source in presence of parental strain restored the wild-type phenotype. Light microscopy revealed a

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8

Islam, MM, Md Mohasin Hussain Khan, and Md Asaduzzaman. "Field evaluation of promising mutants of mungbean against Fela Beetle, Aphid and POD Borer." SAARC Journal of Agriculture 20, no. 1 (2022): 97–106. http://dx.doi.org/10.3329/sja.v20i1.60542.

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Experiment was conducted at the Agricultural Farm of Patuakhali Science and Technology University to know the morphological characteristics of different mutants of mungbean and to find out tolerant/least susceptible mutant(s) against flea beetle, aphid and pod borer based on the reaction of insect pests to promising mutants of mungbean during the period from April to June, 2015. The mutant MBM-07(S)-2 was found to be the tallest (32.57 cm) with highest number of branches/plant (5.03), highest number of leaves/plant (11.06) among all mutants and check variety while MBM-07-Y-2 (23.40 cm) was the

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9

Malek, MA, MR Ismail, FI Monshi, MMA Mondal, and MN Alam. "Selection of Promising Rapeseed Mutants Through Multi-Location Trials." Bangladesh Journal of Botany 41, no. 1 (2012): 111–14. http://dx.doi.org/10.3329/bjb.v41i1.11089.

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Significant variations were observed for most of the characters among the three promising M5 rapeseed mutants. Mutant RM-025 produced the highest seed yield of 1945 kg/ha followed by RM-005 (1892 kg/ha) and had 11.6 and 8.5% higher seed yield, respectively than the control variety. Under farmers management, on an average, mutant RM-025 and RM-005 produced 1824 and 1725 kg/ha with 11.3% and 5.2% higher seed yield, respectively than the control variety. These two mutants also had higher number of primary branches and siliquae/plant, and 1000-seed weight and required shorter maturity period than

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10

Nuraskin, Cut A., Marlina Marlina, R. Idroes, C. Soraya, and Djufri Djufri. "Antibacterial Activity Tests of N-hexane, Ethyl Acetate, and Methanol Leaves (Vitex) Extract (pinnata) against Streptococcus mutans." Open Access Macedonian Journal of Medical Sciences 8, A (2020): 181–84. http://dx.doi.org/10.3889/oamjms.2020.3482.

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BACKGROUND: Vitex pinnata is known as Laban, which is a medicinal plant used traditionally for generations to generations. Laban leaf extract with various concentrations has antibacterial activity. Laban leaf extract is known to inhibit the formation of Streptococcus mutant in human teeth. AIM: To exam, the minimum inhibitory concentration (MIC) and minimum kill concentration (KBM) extract Laban leaves (V. pinnata) as an antibacterial against Streptococcus mutants. METHODS: This research was purely experimental research with design randomized pretest-posttest and control group. The

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11

Khan, MMH, MM Islam, M. Asaduzzaman, and MN Uddin. "Mutants and weather parameters affecting the population dynamics of three major insect pests of Mungbean." SAARC Journal of Agriculture 16, no. 2 (2019): 1–12. http://dx.doi.org/10.3329/sja.v16i2.40254.

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The study was conducted to know the abundance of aphid, flea beetle and pod borer on the mutants viz., MBM-07-Y-1, MBM-07-Y-2, MBM- 656-51-2, MBM-527-114, MBM-07-(S)-2, MBM-347-13, MBM-390-94-Y, MBM-427-87-3, MBM-80 (Local) and a variety BARI moog-6 and the role of weather parameters on the population dynamics of insects at the Agricultural Farm of Patuakhali Science and Technology University from April to June, 2015. Results revealed that the tested mutants did not show resistance against aphid, flea beetle and pod borer. Mutant MBM- 347-13 had the lowest number of flea beetle while mutant MB

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12

Subhadeep, Ganguly, Ghosh Chaudhuri Alok, Bihari Satapathy Kunja, and Kumar Banik Ajit. "Random mutational induction and selection of high yielding strain of Brevibacterium roseum for L-threonine production." Journal of Indian Chemical Society Vol. 95, Sep 2018 (2018): 1121–27. https://doi.org/10.5281/zenodo.5652734.

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Department of Physiology, Vidyasagar College, 39, Sankar Ghosh Lane, Kolkata-700 006 <em>E</em>-<em>mail: </em>res_biol@rediffmail.com Former, PG Department of Botany, Utkal University, Vani Vihar, Bhubaneswar-751 004, Odisha, India Former, Department of Chemical Engineering, Biochemical Engineering Division, Biotechnology Laboratory, University of Calcutta, 92, Acharya Prafulla Chandra Road, Kolkata-700 009, India <em>Manuscript received 25 April 2018, revised 01 June 2018, accepted 28 June 2018</em> The objective of this study was to develop a new auxotrophic mutant of <em>Brevibacterium ros

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M. A. Mondal, M., and M. S. H. Bhuiyan. "Morphological and reproductive characterization of developed mutants in groundnut." International Journal of Advanced Geosciences 8, no. 1 (2020): 21. http://dx.doi.org/10.14419/ijag.v8i1.30338.

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Twenty-eight established groundnut mutants and two check cultivars were studied during Kharif-I (March-June) season of 2017 and 2018 to find out their variability and distinct character(s) as identifying keys. All the mutant lines showed erect type sequential branching habits with two seeds in each pod although they had shown significant variability in all vegetative and reproductive structures. According to cluster analysis, 30 mutants/varieties clustered into three major groups at distance level 60 based on the morphological variability of 14 characters. The variability of 14 morphological c

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14

Baig, Mohammad Hassan, Yun Seong Jo, Sagar Dattatraya Nale, et al. "Abstract 401: HDBNJ3049: A novel EGFR-targeting PROTAC to overcome C797S-mediated osimertinib resistance in NSCLC." Cancer Research 85, no. 8_Supplement_1 (2025): 401. https://doi.org/10.1158/1538-7445.am2025-401.

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The emergence of C797S-driven Osimertinib resistance represents a major hurdle in the treatment of non-small cell lung cancer (NSCLC). This study presents a novel series of proteolysis-targeting chimeras (PROTACs) designed to overcome resistance by potently and selectively degrading EGFR mutants, including the C797S variant. These next-generation EGFR PROTACs demonstrated significant anti-proliferative activity across a broad spectrum of EGFR mutations, achieving subnanomolar potency in cellular proliferation and protein degradation assays alike. Notably, these compounds effectively targeted n

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15

O’Hare, Thomas, Christopher A. Eide, Jeffrey W. Tyner, et al. "Inhibition of T315I Bcr-Abl and Other Imatinib-Resistant Bcr-Abl Mutants by the Selective Abl Kinase Inhibitor SGX70393." Blood 108, no. 11 (2006): 1373. http://dx.doi.org/10.1182/blood.v108.11.1373.1373.

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Abstract Imatinib effectively inhibits the tyrosine kinase activity of Bcr-Abl, the molecular driver of CML. Emergence of imatinib resistance due to mutations within the Bcr-Abl kinase domain (KD) has prompted the development of new Abl kinase inhibitors. A particularly important target is Bcr-Abl(T315I), which accounts for 15–20% of patients with resistance. To address this unresolved need, we profiled the novel Abl kinase inhibitor SGX70393 against native and mutant Bcr-Abl. Methods: We assessed the efficacy of SGX70393 in cellular and biochemical assays against a panel of KD mutants. Cell p

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16

Faihrorrozy, Ni Wayan Sri Suliartini, I. Ketut Ngawit, and Muhammad Hari Aditia Pratama. "Penampilan Karakter Agronomi Beberapa Genotipe Mutan Padi (Oryza Sativa L.) Baas Selem Generasi Kedua (M2) Hasil Induksi Mutasi." Journal of Microbiology, Biotechnology and Conservation 1, no. 1 (2025): 12–25. https://doi.org/10.29303/jmbc.v1i1.6080.

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This study aims to determine the differences in the appearance of agronomic characters of several genotypes of rice mutants (Oryza Sativa L.) The second generation Baas Selem (M2) is the result of mutation induction. This research was conducted in June 2021 - October 2021 in Nyiur Lembang Village, Narmada District, West Lombok Regency. The methods used were group random design (RAK) and Augmented Design with the treatment used, namely 24 genotypes of second generation Baas Selem rice seeds (M2) with control plants. The control plant repeated 3 times, while the mutant plant was 1 time, in its a

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17

Mandal, Aninda, and Animesh K. Datta. "Stability Analysis of a High Fibre Yield and Low Lignin Content “Thick Stem” Mutant in Tossa Jute (Corchorus olitoriusL.)." BioMed Research International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/539869.

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A “thick stem” mutant ofCorchorus olitoriusL. was induced at M2(0.50%, 4 h, EMS) and the true breeding mutant is assessed across generations (M5to M7) considering morphometric traits as well as SEM analysis of pollen grains and raw jute fibres, stem anatomy, cytogenetical attributes, and lignin content in relation to control. Furthermore, single fibre diameter and tensile strength are also analysed. The objective is to assess the stability of mutant for its effective exploration for raising a new plant type in tossa jute for commercial exploitation and efficient breeding. The mutant trait is m

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18

Md. Robiul Islam Akondo, Md. Belal Hossain, Md. Sefaur Rahman, Md. Shamiul Haque, and Md. Abul Kalam Azad. "Screening of suitable tossa jute (Corchorus olitorius L.) mutant to increase fiber production." GSC Biological and Pharmaceutical Sciences 10, no. 2 (2020): 099–105. http://dx.doi.org/10.30574/gscbps.2020.10.2.0014.

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19

SENGUPTA, G. "Characterization of a Lignified Secondary Phloem Fibre-deficient Mutant of Jute (Corchorus capsularis)." Annals of Botany 93, no. 2 (2004): 211–20. http://dx.doi.org/10.1093/aob/mch029.

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20

Satya, Pratik, Ruby Banerjee, Swagata Ghosh, and P. G. Karmakar. "Morpho-anatomical and SSR diversity in mutant gene pool of jute (Corchorus olitoriusL.)." Indian Journal of Genetics and Plant Breeding (The) 74, no. 4 (2014): 478. http://dx.doi.org/10.5958/0975-6906.2014.00873.6.

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21

Akter, Shamima, N. Alam, and PK Roy. "Improvement of sugarcane (Saccharum officinarum L. var. Isd. 39) using gamma irradiation and large scale plantlet production from M1 generation through in vitro culture." Jahangirnagar University Journal of Biological Sciences 5, no. 1 (2016): 1–9. http://dx.doi.org/10.3329/jujbs.v5i1.29738.

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The present study was aimed to develop mutant sugarcane (Saccharum officinarum L. var. Isd. 39) using gamma radiation followed by regeneration of those mutants through in vitro technique. Five different doses of gamma radiation (10, 20, 30, 40 and 50 Gy) were applied to the sugarcane setts and among these doses 10 Gy irradiated mutant sugarcane showed the best agronomical traits. In addition, 10 Gy irradiated mutant sugarcane also contained higher sugar concentrations (14.25%) compared to control (14.23%). On the other hand, shoot tip and young folded leaf segments from the 10 Gy irradiated pl

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22

Lestari, Endang Gati, Iswari Saraswati Dewi, and Rossa Yunita. "Genetic Variability, Heritability and Selection of M2 Sorghum Super 2 Mutant Lines Derived from Irradiation Using Gamma Rays." Romanian Agricultural Research 40 (2023): 19–29. http://dx.doi.org/10.59665/rar4003.

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Sweet sorghum (Sorghum bicolor L. Moench) is a potential plant to be developed as food, feed, and industrial raw materials. In Indonesia, sweet sorghum breeding is needed because only five varieties of sweet sorghum have been released. Genetic variability is essential in breeding. Through mutation induction, breeders can increase genetic variability so that new characters superior to their parents can be obtained. This study aimed to analyze the effect of various doses of gamma-ray irradiation on genetic variability in the agronomic character of the M2 population derived from the sweet sorghum

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Dung, Vu Van, Yoshitaka Umetsu, and Shinya Ohki. "Three-dimensional structure of the complex between calmodulin mutant lacking the c-terminal five residues and the calmodulin-binding peptide derived from skeletal muscle myosin light-chain kinase." TAP CHI SINH HOC 39, no. 3 (2017): 309–19. http://dx.doi.org/10.15625/0866-7160/v39n3.10111.

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In our previous study, functional ability and conformational stability had been examined for C-terminal deletion mutants of a 148-residue Ca2+-binding protein, chicken calmodulin (CaM). In that study, we had reported that a mutant named CCMΔ5, missing five residues at the C-terminus, activates CaM-target as much as full-length CaM does. This finding is intriguing because CCMΔ5 lacks the key residues, Met144 and Met145, for the target activation. To uncover why CCMΔ5 displays proper function, here we report the three-dimensional structure of CCMΔ5 bound to the peptide derived from skeletal musc

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Estep, L. K., M. Zala, N. P. Anderson, et al. "First Report of Resistance to QoI Fungicides in North American Populations of Zymoseptoria tritici, Causal Agent of Septoria Tritici Blotch of Wheat." Plant Disease 97, no. 11 (2013): 1511. http://dx.doi.org/10.1094/pdis-05-13-0486-pdn.

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The G143A mutation in cytb (cytochrome b gene) is associated with high levels of resistance to quinone outside inhibitor (QoI or strobilurin) fungicides that disrupt electron transport during cellular respiration (1). The G143A mutation in Zymoseptoria tritici (synonyms: Mycosphaerella graminicola and Septoria tritici), the causal agent of septoria tritici blotch of wheat (Triticum aestivum), was first reported in Europe in 2001 (1). Although Z. tritici has a global distribution (3), G143A mutants of Z. tritici have not been reported outside of Europe. We used PCR-RFLP (4) to estimate the freq

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Wulandari, Yukarie Ayu, Sobir Sobir, and Syarifah Iis Aisyah. "ANALISIS LINTAS PERTUMBUHAN DAN PRODUKSI TERHADAP PROTEIN KACANG TUNGGAK (Vigna unguiculata L) GENERASI M2." Jurnal AGROSAINS dan TEKNOLOGI 6, no. 1 (2021): 7. http://dx.doi.org/10.24853/jat.6.1.7-14.

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Cowpea (V. unguiculata L) can be developed as a source of vegetable protein because it contains relatively high protein and high lysine. The protein content in seeds is an accumulation of character components that play a role in protein formation, whose relationship can be predicted using cross correlation and analysis coefficients. The study was carried out in the experimental garden of Pasir Kuda PKHT of IPB in February - May 2018. Protein analysis is carriedout in the Testing Laboratory of the Department of Agronomy and Horticulture, Faculty of Agriculture, IPB in June - July 2018. The stud

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Boodwa-Ko, Daphne, and Tamara L. Doering. "A Quick reCAP: Discovering Cryptococcus neoformans Capsule Mutants." Journal of Fungi 10, no. 2 (2024): 114. http://dx.doi.org/10.3390/jof10020114.

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Cryptococcus neoformans is an opportunistic fungal pathogen that can cause severe meningoencephalitis in immunocompromised hosts and is a leading cause of death in HIV/AIDS patients. This pathogenic yeast is surrounded by a polysaccharide capsule that is critical for virulence and plays important roles in host-pathogen interactions. Understanding capsule biosynthesis is therefore key to defining the biology of C. neoformans and potentially discovering novel therapeutic targets. By exploiting methods to identify mutants deficient in capsule, June Kwon-Chung and other investigators have discover

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Mahmud, Kuasha, KM Nasiruddin, MA Hossain, and L. Hassan. "Development of Mutants in Sugarcane through Callus Culture." Plant Tissue Culture and Biotechnology 26, no. 1 (2016): 123–30. http://dx.doi.org/10.3329/ptcb.v26i1.29773.

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The effects of different concentrations (0.0 M, 0.01 M, 0.02 M and 0.03 M for 24 hours treatment) of chemical mutagen like, ethyl methanesulfphonate (EMS) on callus derived from sugarcane var. Isd 37, Isd 39 and Isd 40 were investigated for in vitro plant regeneration. The highest number of shoots (58.33%) was reduced over control of Isd 40 followed by Isd 37 (57.62%) and Isd 39 (the lowest 56.06%), respectively due to the use of EMS for treating calli. The regeneration of mutant plantlets was achieved from EMS (0.01 M) treated calli obtained from leaf sheath explants on MS supplemented with 2

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Kumar Gahlaut, Akhilesh, and Arjun Arjun. "RELATIVE IMPACTS OF DIFFERENT SEASONS ON THE QUALITIES ERISILK COCOONS AND ERI SILK YARN OF FOUR DIFFERENT MUTANTSTRAINS OF PhilosamiariciniBsd." International Journal of Research -GRANTHAALAYAH 4, no. 11 (2016): 103–7. http://dx.doi.org/10.29121/granthaalayah.v4.i11.2016.2426.

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The relative impacts of different seasons of ericulture namely May-June,July-Aug., Sep.-Oct. and Nov.-Dec on the qualities of erisilk cocoons and erisilk yarn of four different mutant strains of PhilosamiariciniViz; Yellow plain, Yellow zebra, G.B. plain and G.B. zebra have been evaluated under the reeling parameters. Results obtained indicate that the reeling performances of G.B. plain mutant strain is best in the season May-June (summer)followed by July-August (Rainy) and are relatively better in respect of qualities of eri cocoons and eri silk yarn in comparison to two other seasons namely

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Mokat, Digambar, Abhijeet Rakshe, and Samadhan Pardhi. "Albino mutant in Tabernaemontana divaricata (L.) R. Br. ex Roem. & Schult. and Azadirachta indica A. Juss." Journal of Non Timber Forest Products 22, no. 2 (2015): 87–89. http://dx.doi.org/10.54207/bsmps2000-2015-3etf21.

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The Tabernaemontana divaricata and Azadirachta indica are most popular plants in India for their wide miraculous therapeutic and other economic uses. The albino mutants were observed in both the plants during May-June, 2015. The albinism was first time observed in T. divaricata.

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Masser, Bailey, Sally Camper, and Leonard Cheung. "PMON145 The Role of Pou3f4 in Pituitary Development and Disease." Journal of the Endocrine Society 6, Supplement_1 (2022): A540—A541. http://dx.doi.org/10.1210/jendso/bvac150.1124.

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Abstract Mutations in the pituitary specific transcription factor Prophet of Pit-1 (PROP1) are the most common genetic etiology of combined pituitary hormone deficiency (CPHD), which affects 1 in 8,000 newborns worldwide. CPHD is associated with short stature, attributable to growth hormone (GH) deficiency and/or thyroid stimulating hormone (TSH) deficiency. Pathogenic lesions impair pituitary development and differentiation of endocrine cells. Prop1-mutant mice show increased expression of genes including SRY-Box Transcription Factor 21 (Sox21) and Pou Domain, Class 3, Transcription Factor 4

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Jeba, D., and K. R. Sheeja. "Antibacterial Activity of Environmentally Sustainable Polyurethane Based Composites from Castor Oil." Oriental Journal Of Chemistry 37, no. 3 (2021): 755–58. http://dx.doi.org/10.13005/ojc/370334.

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In this present work, soft and hard antibacterial polyurethane sheets of different composition have been synthesized from castor oil based polyurethane and which was reinforced with natural and synthetic fibres such as jute, sisal, hemp and glass. The activity of polyurethane sheets and selected antibiotics was evaluated against four bacterial pathogens including Staphylococcusaureus, Streptococcus mutans, E.coli, Pseudomonas aeruginosausing modified disc diffusion method. Among the ten samples, hard polyurethanes displayed potential activity against bacterial pathogens E.coli and Streptococcu

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Choudhary, S. B., I. Chowdhury, R. K. Singh, et al. "Morphological, Histobiochemical and Molecular Characterisation of Low Lignin Phloem Fibre (llpf) Mutant of Dark Jute (Corchorus olitorius L.)." Applied Biochemistry and Biotechnology 183, no. 3 (2017): 980–92. http://dx.doi.org/10.1007/s12010-017-2477-5.

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Chen, Yungchang, Yanhong Deng, Yutong Ma, et al. "Clinical and genomic distinction of class 1/2/3 BRAF-mutant colorectal cancer and differential prognosis." Journal of Clinical Oncology 40, no. 16_suppl (2022): 3533. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.3533.

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3533 Background: Mutations occurring at the V600 amino acid of BRAF is the most common BRAF mutations in colorectal cancer (CRC), which lead to RAS-independent active monomers (Class 1) and are the targets of BRAF inhibitors. BRAF non-V600 mutants can be further classified as RAS-independent active dimers (Class 2) and RAS-dependent impaired kinase (Class 3). The clinical and genetic distinction of CRC patients carrying different subtypes of BRAF mutations remain to be revealed. Methods: A multicenter retrospective study investigated the mutational profiles of 2,118 CRC patients whose baseline

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Dean, Thomas, Thomas Gardella, Harald Jüppner, Sophia Savransky, Jean-Pierre Vilardaga, and Ignacio Portales-Castillo. "OR21-3 Spatial Signaling Bias of a Gain-of-Function PTH1R Mutant Associated with Delayed Ossification in Eiken Syndrome." Journal of the Endocrine Society 6, Supplement_1 (2022): A194. http://dx.doi.org/10.1210/jendso/bvac150.400.

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Abstract Skeletal development is orchestrated by the interaction of the parathyroid hormone related peptide (PTHrP) with the parathyroid hormone receptor type 1 (PTH1R). Knock-out or severe deficiency of either PTH1R or PTHrP by homozygous loss-of-function mutations results in premature hypertrophy of chondrocytes and accelerated bone mineralization, leading to neonatal death. In contrast, patients with a heterozygous gain-of-function PTH1R mutation (H223R, T410P/R or I458K/R) present with Jansen metaphyseal chondrodysplasia (JMC), characterized by delayed bone mineralization, hypercalcemia, h

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Wibisono, Kunto, Syarifah Iis Aisyah, Waras Nurcholis, and Sri Suhesti. "Performance of Putative Mutants and Genetic Parameters of Plectranthus amboinicus (L.) through Mutation Induction With Colchicine." AGROSAINSTEK: Jurnal Ilmu dan Teknologi Pertanian 5, no. 2 (2021): 89–99. http://dx.doi.org/10.33019/agrosainstek.v5i2.247.

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Genetic enhancement in vegetatively propagated crops can be done through mutation induction. Colchicine-induced mutation is one of the methods that can be employed to increase plant genetic diversity. This study aimed to determine the effect of colchicine on the performance and genetic parameters of MV3 generation of Plectranthus amboinicus (L.). This study was conducted at the Laboratory of Agricultural Seed Management, Plantation Research and Development Center, from June 2018 to June 2019. Nodes and shoots were used as explants. Mutation induction was performed using colchicine at concentra

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Flavio, Martinez-Morales, Aranda Romo Saray, and Hugo Aragon-Martinez Othoniel. "Anticariogenic action and safety profile of a cacao bean husk extract: A systematic review and meta-analysis." GSC Advanced Research and Reviews 8, no. 1 (2021): 118–27. https://doi.org/10.5281/zenodo.5168341.

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Nowadays, there is not a meta-analytic synthesis of the clinical reports that used a cacao bean husk extract (CBHE) solution as an anticariogenic mouth rinse. Thus, the aim of this study was to evaluate that information through a systematic review and meta-analysis methodology, conducted in accordance with PRISMA guidelines. Scientific databases were searched for studies published up to June 2021. Inclusion and exclusion criteria were applied to studies found and then, their data was analyzed. The five selected studies were categorized with a 36.6, 58.5, and 4.9 % of a low, unclear, and high r

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Sultana, Sayeda, Kakon Chakma, Saidur Rahman, and Mohammed Bhuiyan. "Climate Resilient Varietal Development of Diverse Crops through Mutation Breeding in Bangladesh." Fundamental and Applied Agriculture 8, no. 3 (2023): 524. http://dx.doi.org/10.5455/faa.169849.

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The capability to quickly generate a considerable range of genetic variation in plants through mutation enables the mutagenesis approach extremely successful in developing climate-resistant cultivars across the entire world. In Bangladesh, plant breeders are confronted with a significant challenge in producing resilient and high-yielding cultivars rapidly capable of adapting to the changing environment in this densely populated region. Based on Mutant varieties data of Bangladesh which are available in the domain of FAO/IAEA Mutant Varieties Database (MVD), this review attempted to highlight t

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Carvajal, Richard D., Jeffrey Alan Sosman, Fernando Quevedo, et al. "Phase II study of selumetinib (sel) versus temozolomide (TMZ) in gnaq/Gna11 (Gq/11) mutant (mut) uveal melanoma (UM)." Journal of Clinical Oncology 31, no. 15_suppl (2013): CRA9003. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.cra9003.

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CRA9003 The full, final text of this abstract will be available at abstract.asco.org at 7:30 AM (EDT) on Saturday, June, 1, 2013, and in the Annual Meeting Proceedings online supplement to the June 20, 2013, issue of Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Saturday edition of ASCO Daily News.

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Choudhary, Shashi Bhushan, Dipnarayan Saha, Hariom Kumar Sharma, et al. "Transcriptional analysis of a delayed-flowering mutant under short-day conditions reveal genes related to photoperiodic response in tossa jute (Corchorus olitorius L.)." Industrial Crops and Products 132 (June 2019): 476–86. http://dx.doi.org/10.1016/j.indcrop.2019.03.001.

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Suliartini, Ni Wayan Sri, Mita Sapitri, I. Wayan Sudika, I. Gusti Putu Muliarta Aryana, and Anak Agung Ketut Sudharmawan. "Karakterisasi dan Keragaman Genetik Mutan Padi Inpago Unram 1 Generasi Kedua (M2) Akibat Iradiasi Sinar Gamma." JURNAL SAINS TEKNOLOGI & LINGKUNGAN 8, no. 2 (2022): 124–36. http://dx.doi.org/10.29303/jstl.v8i2.364.

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This study aims to determine the quantitative character of the mutant genotype (M2) and the genetic diversity of the mutant (M2) due to gamma ray irradiation. This experiment was carried out from June to October 2021 in Nyurlembang Village, Narmada District, West Lombok Regency, West Nusa Tenggara, using a Randomized Block Design (RAK) in a partitioned design with a total of 27 treatments consisting of 24 mutant plant genotypes and 3 comparison plants. The results of the observations were analyzed using analysis of variance at a level of 5%, then significantly different treatments were further

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Chibaudel, Benoist, Hubert Richa, Elisabeth Carola, et al. "Clinical/molecular features and prognostic significance of RAS mutant-low versus RAS mutant-high in patients with metastatic colorectal cancer." Journal of Clinical Oncology 42, no. 3_suppl (2024): 187. http://dx.doi.org/10.1200/jco.2024.42.3_suppl.187.

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187 Background: Addressing tumor heterogeneity is one of the main advantage of liquid biopsy over tissue biopsy, as liquid biopsy is likely to better reflect the global molecular profile (primary tumor site and metastatic disease). Variant Allele Frequency (VAF) represents the fraction of sequencing reads in which a variant is observed. The aim was to evaluate the prognostic value of circulating tumor (ct) VAF for KRAS and NRAS genes in patients with ctRAS mutant metastatic colorectal cancer (MCRC). Methods: Circulating comprehensive genomic profiling using FoundationOne Liquid CDx (FO-Liq) wa

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Subhadeep, Ganguly. "Isolation, characterization and improvement on a wild strain of Corynebacterium glutamicum for L-glutamic acid production." Journal of Indian Chemical Society Vol. 96, Jun 2019 (2019): 705–10. https://doi.org/10.5281/zenodo.5647895.

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Department of Physiology, Vidyasagar College, 39, Sankar Ghosh Lane, Kolkata-700 006, India <em>E-mail:</em> res_biol@rediffmail.com <em>Manuscript received online 05 February 2019, accepted 14 June 2019</em> L-Glutamic acid is a non-essential, proteinogenic amino acid, largely used as a flavoring agent, animal food additive and also in therapeutic purposes. Different strains of Corynebacterium glutamicum are widely used for its large scale production by means of fermentation. The present study was aimed to isolate and characterize an wild strain of <em>Corynebacterium glutamicum</em> from Nor

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Kundu, Avijit, Debabrata Sarkar, Nur Alam Mandal, Mohit Kumar Sinha, and Bikash Sinha Mahapatra. "A secondary phloic (bast) fibre-shy (bfs) mutant of dark jute (Corchorus olitorius L.) develops lignified fibre cells but is defective in cambial activity." Plant Growth Regulation 67, no. 1 (2012): 45–55. http://dx.doi.org/10.1007/s10725-012-9660-z.

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Rana, Md Masud, Md Ashraful Islam, Shahin Imran, Silve Rubani, and Lutful Hassan. "Morphological characterization of NERICA mutant lines and their parents." Asian Journal of Medical and Biological Research 4, no. 2 (2018): 207–21. http://dx.doi.org/10.3329/ajmbr.v4i2.38257.

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A total of 10 NERICA lines (7 mutants along with 3 parents) of advanced generations were used for morphological and molecular characterization. The experiments were conducted in both Aus and Aman season, 2014 under different field conditions at the field of Biotechnology division, BINA, BAU Campus, Mymensingh-2202 following Randomized Complete Block Design (RCBD) with three replications. The genotypes differed significantly for all the traits. The seasonal differences on all the traits except 100-seed weight were also highly significant. The season’s × genotypes interactions were highly signif

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Mondal, M. Monjurul Alam, Md Azadul Haque, and Md Mohimenul Islam. "Physiological causes of yield variation in similar durated mungbean genotypes." Journal of Bangladesh Academy of Sciences 47, no. 1 (2023): 101–8. http://dx.doi.org/10.3329/jbas.v47i1.64895.

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The experiment was conducted during February to May, 2019 at the research farm of Bangladesh Institute of Nuclear Agriculture, Mymensingh-2202. The objective of the study was to evaluate the growth, reproductive characteristics, yield and yield components of four similar durated mungbean genotypes, namely BARI Mung-2, Binamoog-2, MB-29, and MB-43. At most of the growth stages, the mutant MB-29 showed superiority in terms of growth parameters such as total dry matter, leaf area index, absolute growth rate, relative growth rate, and net assimilation rate whilst MB-43 showed the inferiority. Furt

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Kurniati, Nining. "Aktivitas Antiadhesi Kombinasi Ekstrak Daun Pepaya dan Daun Sirih Hijau Terhadap Neutrofil pada Streptococcus Mutans, Staphylococcus Aurues dan Escheriachia Coli." Jurnal Forum Kesehatan : Media Publikasi Kesehatan Ilmiah 13, no. 1 (2023): 25–30. http://dx.doi.org/10.52263/jfk.v13i1.217.

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Indonesia, menurut survei nasional riskesdas 2018, sebanyak 45,3% setara 1,2 juta penduduk mengalami karies gigi, untuk menanggulangi penyakit infeksi tersebut digunakan antibiotik. Antibiotik merupakan substansi yang dihasilkan suatu mikroorganisme, yang mempunyai kemampuan untuk menghambat pertumbuhan atau membunuh mikroorganisme. Negara berkembang terjadi masalah, timbulnya strain bakteri resisten terhadap antibiotik pada penyakit infeksi. Papain yang terkandung dalam daun pepaya merupakan enzim proteolitik juga memiliki efek bakterisid dan bakteriostatik, diharapkan kombinasi daun sirih me

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Babey, Muriel, William Krause, Xiao Zhang, et al. "RF18 | PSAT143 Brain Determinants of Dynamic Bone Remodeling in Females." Journal of the Endocrine Society 6, Supplement_1 (2022): A226—A227. http://dx.doi.org/10.1210/jendso/bvac150.465.

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Abstract Central estrogen signaling in the medial basal hypothalamus (MBH) coordinates energy expenditure, food intake, and reproduction, as well as skeletal homeostasis. Prior work from our lab found that estrogen signaling via Estrogen Receptor alpha (ERa) in the arcuate (ARC) nucleus normally restrains bone formation in female mice only. We asked if the high bone mass in the Esr1Nkx2-1Cre mouse model, which ablates ERa in the MBH, is maintained or deteriorates with chronic overnutrition, as this is known to increase bone frailty in humans. To carry out this study, Esr1Nkx2-1Cre mutant femal

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Lloyd, M. Cooper, Melinda Sanders, Maria Gabriela Kuba, et al. "Clinical and pathologic characteristics of patients with PI3K-mutant breast cancers." Journal of Clinical Oncology 31, no. 26_suppl (2013): 8. http://dx.doi.org/10.1200/jco.2013.31.26_suppl.8.

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8 Background: Mutations in PIK3CA are the most common somatic alterations in breast cancer and represent a potentially useful therapeutic target. As more PI3K pathway inhibitors enter the clinical arena, it is important to understand the characteristics of patients harboring mutations. This study seeks to identify the clinico/pathological characteristics of PI3K mutant breast cancers in patients evaluated at Vanderbilt University Medical Center. Methods: Molecular profiling (SNaPShot) was used to detect mutations in three genes in the PI3K pathway (PIK3CA, PTEN, AKT1). Electronic medical recor

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Rachiglio, Anna, Francesca Fenizia, Maria Piccirillo, et al. "The Presence of Concomitant Mutations Affects the Activity of EGFR Tyrosine Kinase Inhibitors in EGFR-Mutant Non-Small Cell Lung Cancer (NSCLC) Patients." Cancers 11, no. 3 (2019): 341. http://dx.doi.org/10.3390/cancers11030341.

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Recent findings suggest that a fraction of EGFR-mutant non-small-cell lung cancers (NSCLC) carry additional driver mutations that could potentially affect the activity of EGFR tyrosine kinase inhibitors (TKIs). We investigated the role of concomitant KRAS, NRAS, BRAF, PIK3CA, MET and ERBB2 mutations (other mutations) on the outcome of 133 EGFR mutant patients, who received first-line therapy with EGFR TKIs between June 2008 and December 2014. Analysis of genomic DNA by Next Generation Sequencing (NGS) revealed the presence of hotspot mutations in genes other than the EGFR, including KRAS, NRAS

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Lăzureanu, Dorela-Codruța, Diana Herman, Marioara Cornianu, Octavia Vița, Robert Barna, and Alis Dema. "Immunohistochemical testing of IDH mutation in gliomas: diagnostic, prognostic and predictive impact." Timisoara Medical Journal 2024, no. 3 (2024): 1. https://doi.org/10.35995/tmj20240212.

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The objective of the study was to investigate the immunohistochemical expression of isocitrate dehydrogenase in tissue samples from patients with surgically managed gliomas. Material and methods. Biopsies from 20 patients that underwent neurosurgery for brain tumors from January to June 2024 in Timișoara County Hospital, were formalin-fixed and paraffin-embedded. In addition to the routine stain, the immunohistochemical technique with anti-IDH1 antibody (R132H) was used. Results: The routine stain showed the predominant fibrillar pattern with variable cell densities, the inconstant presence of

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