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1

La Maida, Nunzia, Manuela Pellegrini, Esther Papaseit, et al. "Determination of the Synthetic Cannabinoids JWH-122, JWH-210, UR-144 in Oral Fluid of Consumers by GC-MS and Quantification of Parent Compounds and Metabolites by UHPLC-MS/MS." International Journal of Molecular Sciences 21, no. 24 (2020): 9414. http://dx.doi.org/10.3390/ijms21249414.

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The consumption of synthetic cannabinoids (SCs) has significantly increased in the last decade and the analysis of SCs and their metabolites in human specimens is gaining interest in clinical and forensic toxicology. A pilot study has been carried out using a combination of an initial last generation gas chromatography-mass spectrometry (GC-MS) screening method for the determination of JWH-122, JWH-210, UR-144) in oral fluid (OF) of consumers and an ultra-high performance liquid chromatography high resolution mass spectrometry (UHPLC-HRMS) confirmatory method for the quantification of the pare
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2

Brajković, Gordana, Jasmina Jović-Stošić, Snežana Đorđević, et al. "Determination of JWH-210, JWH-122 and JWH-081 in urine by Liquid Chromatography Mass Spectrometric method." Toxicology Letters 280 (October 2017): S292. http://dx.doi.org/10.1016/j.toxlet.2017.07.820.

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3

Hutter, Melanie, Bjoern Moosmann, Volker Auwärter, and Merja A. Neukamm. "Hair analysis for JWH-018, JWH-122, and JWH-210 after passive in vivo exposure to synthetic cannabinoid smoke." Forensic Toxicology 33, no. 1 (2014): 69–76. http://dx.doi.org/10.1007/s11419-014-0251-8.

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4

Pellegrini, Manuela, Emilia Marchei, Esther Papaseit, Magí Farré, and Simona Zaami. "UHPLC-HRMS and GC-MS Screening of a Selection of Synthetic Cannabinoids and Metabolites in Urine of Consumers." Medicina 56, no. 8 (2020): 408. http://dx.doi.org/10.3390/medicina56080408.

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Background and Objectives: The use of synthetic cannabinoids has increased around the world. As a result, the implementation of accurate analysis in human biological matrices is relevant and fundamental. Two different analytical technologies, ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) and high-sensitivity gas chromatography-mass spectrometry (GC-MS) were used for the determination of three synthetic cannabinoids JWH-122, JWH 210, UR-144 and their metabolites in urine of consumers. Materials and Methods: Sample preparation included an initial hyd
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5

Almada, Marta, Patrícia Alves, Bruno M. Fonseca, et al. "Synthetic cannabinoids JWH-018, JWH-122, UR-144 and the phytocannabinoid THC activate apoptosis in placental cells." Toxicology Letters 319 (February 2020): 129–37. http://dx.doi.org/10.1016/j.toxlet.2019.11.004.

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6

Kusano, Maiko, Mayumi Yamanaka, Kei Zaitsu, et al. "Regioisomeric differentiation of the alkyl-substituted synthetic cannabinoids JWH-122 and JWH-210 by GC-EI-MS/MS." Forensic Toxicology 34, no. 2 (2016): 304–15. http://dx.doi.org/10.1007/s11419-016-0317-x.

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7

Schaefer, Nadine, Benjamin Peters, Dietmar Bregel, Hans H. Maurer, Peter H. Schmidt, and Andreas H. Ewald. "Can JWH-210 and JWH-122 be detected in adipose tissue four weeks after single oral drug administration to rats?" Biomedical Chromatography 28, no. 8 (2014): 1043–47. http://dx.doi.org/10.1002/bmc.3137.

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8

Ernst, Ludger, Hans-Martin Schiebel, Claudine Theuring, Rainer Lindigkeit, and Till Beuerle. "Identification and characterization of JWH-122 used as new ingredient in “Spice-like” herbal incenses." Forensic Science International 208, no. 1-3 (2011): e31-e35. http://dx.doi.org/10.1016/j.forsciint.2011.03.020.

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9

Hruba, Lenka, and Lance R. McMahon. "Apparent Affinity Estimates and Reversal of the Effects of Synthetic Cannabinoids AM-2201, CP-47,497, JWH-122, and JWH-250 by Rimonabant in Rhesus Monkeys." Journal of Pharmacology and Experimental Therapeutics 362, no. 2 (2017): 278–86. http://dx.doi.org/10.1124/jpet.117.240572.

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10

Coppola, Maurizio, and Raffaella Mondola. "JWH-122 Consumption Adverse Effects: A Case of Hallucinogen Persisting Perception Disorder Five-Year Follow-Up." Journal of Psychoactive Drugs 49, no. 3 (2017): 262–65. http://dx.doi.org/10.1080/02791072.2017.1316431.

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11

Fonseca, Bruno M., Renata Fernandes, Marta Almada, et al. "Synthetic cannabinoids and endometrial stromal cell fate: Dissimilar effects of JWH-122, UR-144 and WIN55,212-2." Toxicology 413 (February 2019): 40–47. http://dx.doi.org/10.1016/j.tox.2018.11.006.

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12

De Brabanter, Nik, Simone Esposito, Lore Geldof, et al. "In vitro and in vivo metabolisms of 1-pentyl-3-(4-methyl-1-naphthoyl)indole (JWH-122)." Forensic Toxicology 31, no. 2 (2013): 212–22. http://dx.doi.org/10.1007/s11419-013-0179-4.

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13

Vučinić, Slavica, Vesna Kilibarda, Snežana Đorđević, et al. "Clinical and analytical experience of the National Poison Control Centre with synthetic cannabinoids." Archives of Industrial Hygiene and Toxicology 69, no. 2 (2018): 178–85. http://dx.doi.org/10.2478/aiht-2018-69-3096.

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AbstractA rising number of patients are being treated for overdosing with new psychoactive substances (NPS) available at the illegal drug market in Serbia. The aim of this study was to report clinical and analytical experience of the National Poison Control Centre of Serbia (NPCC) with synthetic cannabinoids (SCs) and point to the NPS available at the illegal drug market in our country. From January 2013 to December 2016, 58 patients (aged between 14 and 25) were treated for the effects of synthetic cannabinoids at the NPCC. Tachycardia was established in 53, mydriasis in 31, somnolence, nause
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14

Nakajima, Jun’ichi, Misako Takahashi, Takako Seto, et al. "Identification and quantitation of two benzoylindoles AM-694 and (4-methoxyphenyl)(1-pentyl-1H-indol-3-yl)methanone, and three cannabimimetic naphthoylindoles JWH-210, JWH-122, and JWH-019 as adulterants in illegal products obtained via the Internet." Forensic Toxicology 29, no. 2 (2011): 95–110. http://dx.doi.org/10.1007/s11419-011-0108-3.

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15

Jang, Moonhee, Ilchung Shin, Wonkyung Yang, et al. "Determination of major metabolites of MAM-2201 and JWH-122 in in vitro and in vivo studies to distinguish their intake." Forensic Science International 244 (November 2014): 85–91. http://dx.doi.org/10.1016/j.forsciint.2014.08.008.

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16

Costain, Willard J., Ingrid Rasquinha, Tanya Comas, et al. "Analysis of the pharmacological properties of JWH-122 isomers and THJ-2201, RCS-4 and AB-CHMINACA in HEK293T cells and hippocampal neurons." European Journal of Pharmacology 823 (March 2018): 96–104. http://dx.doi.org/10.1016/j.ejphar.2018.01.043.

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17

Silva, João P., Ana Margarida Araújo, Paula Guedes de Pinho, Helena Carmo, and Félix Carvalho. "Synthetic Cannabinoids JWH-122 and THJ-2201 Disrupt Endocannabinoid-Regulated Mitochondrial Function and Activate Apoptotic Pathways as a Primary Mechanism of In Vitro Nephrotoxicity at In Vivo Relevant Concentrations." Toxicological Sciences 169, no. 2 (2019): 422–35. http://dx.doi.org/10.1093/toxsci/kfz050.

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18

Larabi, Islam Amine, Mohammed Riffi, Nicolas Fabresse, Isabelle Etting, and Jean-Claude Alvarez. "Validation of an UPLC-MS/MS method for the determination of sixteen synthetic cannabinoids in human hair. Application to document chronic use of JWH-122 following a non-fatal overdose." Toxicologie Analytique et Clinique 31, no. 4 (2019): 283–92. http://dx.doi.org/10.1016/j.toxac.2019.10.005.

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19

Martínez, Lucia, Nunzia La Maida, Esther Papaseit, et al. "Acute Pharmacological Effects and Oral Fluid Concentrations of the Synthetic Cannabinoids JWH-122 and JWH-210 in Humans After Self-Administration: An Observational Study." Frontiers in Pharmacology 12 (August 19, 2021). http://dx.doi.org/10.3389/fphar.2021.705643.

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Synthetic cannabinoids (SCs) are a group of new psychoactive drugs used recreationally with potential health risks. They are monitored by the EU Early Warning System since 2010 due to severe adverse effects on consumers. JWH-122 and JWH-210 are naphthoylindole SCs and potent cannabinoid receptor CB1 and CB2 agonists. Information about the effects of SCs usually is available from intoxication cases and surveys, and few studies on humans after controlled administration or observational/naturalistic studies using standardized measures of cardiovascular and subjective effects are available. The ai
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20

Goebel, August, Marcus Boehm, Hartmut Kirchherr, and W. Nikolaus Kühn-Velten. "Simultaneous identification and quantification of synthetic cannabinoids (cannabimimetics) in serum, hair, and urine by rapid and sensitive HPLC tandem mass spectrometry screenings: overview and experience from routine testing." Laboratoriumsmedizin 37, no. 4 (2013). http://dx.doi.org/10.1515/labmed-2012-0059.

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AbstractDetection and quantification of synthetic cannabinoids (synonym: cannabimimetics) used as a substitute for natural cannabis has been a real toxicological and forensic issue since 2008. On the basis of a short overview of the pharmacological principle, chemical classification, and legal situation in Germany, the development of several analytical and screening approaches is presented. The paper further describes and validates a novel method for the simultaneous identification and quantification of JWH-018, JWH-019, JWH-073, JWH-081, JWH-122, JWH-200, JWH-210, JWH-250, WIN48,098, WIN55,21
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21

Wohlfarth, Ariane, Karl B. Scheidweiler, Marisol Castaneto, et al. "Urinary prevalence, metabolite detection rates, temporal patterns and evaluation of suitable LC-MS/MS targets to document synthetic cannabinoid intake in US military urine specimens." Clinical Chemistry and Laboratory Medicine (CCLM) 53, no. 3 (2015). http://dx.doi.org/10.1515/cclm-2014-0612.

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AbstractIdentifying synthetic cannabinoid designer drug abuse challenges toxicologists and drug testing programs. The best analytical approach for reliably documenting intake of emerging synthetic cannabinoids is unknown. Primarily metabolites are found in urine, but optimal metabolite targets remain unknown, and definitive identification is complicated by converging metabolic pathways.We screened 20,017 US military urine specimens collected from service members worldwide for synthetic cannabinoids between July 2011 and June 2012. We confirmed 1432 presumptive positive and 1069 presumptive neg
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22

Rácz, Norbert, Tibor Veress, Júlia Nagy, Balázs Bobály, and Jenő Fekete. "Separation of Isomers of JWH-122 on Porous Graphitic Carbon Stationary Phase with Non-Aqueous Mobile Phase Using Intelligent Software." Journal of Chromatographic Science, September 27, 2016. http://dx.doi.org/10.1093/chromsci/bmw131.

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23

Davidsen, Anders Bork, Marie Mardal та Kristian Linnet. "In Vitro Metabolism and Hepatic Intrinsic Clearance of the Synthetic Cannabinoid Receptor Agonist JWH-122 and Its Four ω-Halogenated Analogues". AAPS Journal 21, № 4 (2019). http://dx.doi.org/10.1208/s12248-019-0338-6.

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