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Tharp, Darla L. "Role of the intermediate-conductance Ca²⁺-activated K⁺ channel (K[ca]3.1) in coronary smooth muscle cell phenotypic modulation." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/5936.
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Thesis (Ph. D.)--University of Missouri-Columbia, 2007.The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "December 2007" Includes bibliographical references.
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Tucker, Joseph Edward Lovell. "Molecular studies on the retinal rod Na/Ca§+K exchanger." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0025/NQ49544.pdf.
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Seagar, Michael. "Etude d'un canal K/Ca activité à l'aide d'une neurotoxine : l'apamine." Aix-Marseille 2, 1986. http://www.theses.fr/1986AIX22014.
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Utilisation des derives de l'apamine comme marqueurs biochimiques pour caracteriser cet ionophore membranaire des cellules nerveuses. L'apamine radioiodee se fixe sur un recepteur a haute affinite present dans les neurones, les cellules gliales et les preparations de membranes synaptiques
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Rajabipour, Ali. "Effects of Ca, K and water table depth on tomato mechanical properties." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=39984.
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Two series of tests were performed in summer 1993 and repeated in summer 1994 to investigate effects of potassium, calcium and water table depth on mechanical properties of tomato fruit. In the first group of tests five mechanical properties stress, strain, ER (ratio of stress to strain at break), energy and toughness were calculated from the force-deformation curve obtained by compression of pericarp disks taken from tomato fruits (cv New Yorker) at the breaker stage. In the second group of tests force, deformation and energy were obtained from puncture tests on whole tomato fruit. The textural parameters were used to compare the effects of the potassium, calcium and water level depths on the mechanical properties of tomatoes. Results showed the effects of calcium and water table depths on the mechanical properties were significant. Tomato fruits exposed to increasing moisture stress levels by increasing water table depth exhibited increased firmness. Increased application of calcium also resulted in increased firmness. Application of different potassium levels had in general no significant effect on breaking stress, strain, ER, energy and toughness of tomato fruit pericarp.A new method of measuring skin strength of tomatoes is described. The method, refered to as loop method, overcame the problems with the existing method using mechanical grips. Further, the loop method was applied to measure the effect of potassium and calcium on skin strength of tomato. Using the loop method, data were collected on relaxation of tomato skin (epidermis). A computer program was written to model th tensile stress relaxation behaviour of tomato skin. The program was employed to calculate linear and non-linear coefficients of a relaxation model. The fitted values were in a very good agreement with experimental data (R$ sp2>$0.99).
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Moncrieff, Kathleen Elizabeth. "Development of a New Ca II H and K Spectrophotometric Temperature Index." BYU ScholarsArchive, 2007. https://scholarsarchive.byu.edu/etd/1486.
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We are developing a new spectrophotometric temperature index based on the Ca II H and K lines. Because these lines are present even in very cool stars and because the Ca II H line is blended with the H-epsilon line in hot stars, this index should cover a very broad range of spectral types. Our data set consisted of 95 stars with spectral types ranging from O9 to M1. We examined five different indices based on the Ca II H + H-epsilon and K lines, as well as single-wavelength indices centered on each of the H-delta and H-gamma lines, which are in the same region of the spectrum. We compared our new index value with the H-beta index values for the stars in our data set that had published H-beta values. We found that the Ca II K-H index was the best temperature indicator with the widest range in magnitude of the indices we examined.
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Cecil, Mary Robinson. "Development and Application of Geochronometric Techniques to the Study of Sierra Nevada Uplift and the Dating of Authigenic Sediments." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/195423.
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This dissertation contains studies that use various geochronometric and thermochronometric techniques to better understand the post-magmatic evolution of Sierra Nevada, California. (U-Th)/He ages in apatite and zircon from Sierran batholithic rocks are used to constrain the Cenozoic exhumation of the northern part of the range. Zircon and apatite ages determined from the same samples revealed relatively rapid cooling and exhumation rates (0.2 - 0.8 km/My) from ~ 90 to 60 Ma, followed by tectonic quiescence and slow exhumation (0.02 - 0.04 km/My) from the late Paleocene to present. In addition to the thermochronology of basement lithologies, the detrital zircon geochronology of grains from preserved Eocene fluvial sediments in the central and northern Sierra Nevada was performed. U-Pb ages of detrital zircons from the deposits were found to have distributions closely matching age-area estimates of Mesozoic plutons in the Sierra Nevada, suggesting that Eocene river systems were draining local Sierran catchments and likely had steeper axial gradients than has been proposed. Provenance analysis of the Eocene sediments is used to provide constraints on the paleotopography of the Sierra Nevada and inferred range-wide Cenozoic uplift.In addition to the Sierra Nevada work, this dissertation also contains studies that focus on the development of the K-Ca system as a geochronometric technique suitable for dating the deposition of sedimentary sequences. We present a new method for measuring Ca isotopic ratios using a multi-collector ICP-MS equipped with a hexapole collision cell. Isobaric argon interferences are minimized via gas phase reactions in the collision cell. The reproducibility of Ca ratio measurements is found to be ~ 0.02 % (RSD), which is comparable to high precision TIMS techniques and an order of magnitude improvement over single collector ICP-MS techniques using a similar reaction cell method. K-Ca ages of glauconite and K-rich evaporites are determined in order to evaluate the usefulness of the K-Ca system as a sedimentary geochronometer. K-Ca ages in both glauconite and K-salts are found to be variable and significantly younger than documented depositional ages. Reported ages, however, are thought to be recording important basinal thermal histories and recrystallization events.
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Sousa, Renan Lima de [UNESP]. "Doses de Ca e K na produção de pimentão fertirrigado em ambiente protegido." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/151566.
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Com o objetivo de avaliar o desenvolvimento e produção do cultivar ‘Gaston’ submetido a doses de cálcio e potássio, utilizando extratores de solução do solo, instalou-se a presente pesquisa em vasos na estufa agrícola do Departamento de Solos e Recursos Ambientais da Universidade Estadual Paulista “Júlio de Mesquita Filho” - Campus de Botucatu. Com delineamento em blocos casualizados e quatro repetições, foi conduzido um experimento testando quatro doses de Ca (98 kg.ha-1, 196 kg ha-1, 294 kg ha-1 e 392,0 kg ha-1) e outro experimento com 4 doses de K2O (363 kg ha-1, 726 kg ha-1, 1088 kg ha-1 e 1451 kg ha-1) aplicados via fertirrigação por gotejamento. Foram avaliados: a extração semanal da solução do solo, altura da planta, concentração de nutrientes (folha, fruto e solo) e produção. Os extratores permitiram monitoramento eficiente e houve diferença significativa entre os tratamentos. O aumento da concentração de sais na solução do solo reduziu a altura das plantas, número de frutos e a produção. As doses, além da calagem, que proporcionaram maior produção de frutos foram: 98 kg ha-1 de Ca com 46,5 t ha-1 e 363 kg ha-1 de K2O com 39,2 t ha-1.
With the objective of evaluating the development and production of 'Gaston' cultivar submitted to calcium and potassium doses, use soil solution extractors, the present research in pots in the greenhouse of the Department of Soils and Environmental Resources of the State University Paulista "Júlio de Mesquita Filho" - Campus of Botucatu. A randomized complete block design with four replications was carried out by testing four Ca doses (98 kg ha-1 , 196 kg ha-1 , 294 kg ha-1 and 392.0 kg ha-1 ) and another experiment with 4 doses of K2O (363 kg ha-1 , 726 kg ha-1 , 1088 kg ha-1 and 1451 kg ha-1 ) applied via drip fertigation. Was evaluated: a weekly extraction of soil solution, plant height, nutrient concentration (leaf, fruit and soil) and production. The extractors allowed efficient monitoring and great difference between the treatments. Increasing the concentration of salts in the soil solution reduced plant height, number of fruits and yield. The doses, besides liming, that provide higher fruit yield: 98 kg ha- 1 of Ca with 46.5 t ha-1 and 363 kg ha-1 of K2O with 39.2 t ha-1 .
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Sousa, Renan Lima de 1991. "Doses de Ca e K na produção de pimentão fertirrigado em ambiente protegido /." Botucatu, 2017. http://hdl.handle.net/11449/151566.
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Orientador: Roberto Lyra Villas BôasBanca: Poliana Rocha D' Almeida Mota Suares
Banca: Caroline de Moura D Andréa Mateus
Resumo: Com o objetivo de avaliar o desenvolvimento e produção do cultivar 'Gaston' submetido a doses de cálcio e potássio, utilizando extratores de solução do solo, instalou-se a presente pesquisa em vasos na estufa agrícola do Departamento de Solos e Recursos Ambientais da Universidade Estadual Paulista "Júlio de Mesquita Filho" - Campus de Botucatu. Com delineamento em blocos casualizados e quatro repetições, foi conduzido um experimento testando quatro doses de Ca (98 kg.ha-1, 196 kg ha-1, 294 kg ha-1 e 392,0 kg ha-1) e outro experimento com 4 doses de K2O (363 kg ha-1, 726 kg ha-1, 1088 kg ha-1 e 1451 kg ha-1) aplicados via fertirrigação por gotejamento. Foram avaliados: a extração semanal da solução do solo, altura da planta, concentração de nutrientes (folha, fruto e solo) e produção. Os extratores permitiram monitoramento eficiente e houve diferença significativa entre os tratamentos. O aumento da concentração de sais na solução do solo reduziu a altura das plantas, número de frutos e a produção. As doses, além da calagem, que proporcionaram maior produção de frutos foram: 98 kg ha-1 de Ca com 46,5 t ha-1 e 363 kg ha-1 de K2O com 39,2 t ha-1.
Abstract: With the objective of evaluating the development and production of 'Gaston' cultivar submitted to calcium and potassium doses, use soil solution extractors, the present research in pots in the greenhouse of the Department of Soils and Environmental Resources of the State University Paulista "Júlio de Mesquita Filho" - Campus of Botucatu. A randomized complete block design with four replications was carried out by testing four Ca doses (98 kg ha-1, 196 kg ha-1, 294 kg ha-1 and 392.0 kg ha-1 ) and another experiment with 4 doses of K2O (363 kg ha-1, 726 kg ha-1, 1088 kg ha-1 and 1451 kg ha-1 ) applied via drip fertigation. Was evaluated: a weekly extraction of soil solution, plant height, nutrient concentration (leaf, fruit and soil) and production. The extractors allowed efficient monitoring and great difference between the treatments. Increasing the concentration of salts in the soil solution reduced plant height, number of fruits and yield. The doses, besides liming, that provide higher fruit yield: 98 kg ha- 1 of Ca with 46.5 t ha-1 and 363 kg ha-1 of K2O with 39.2 t ha-1 ...
Mestre
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Nzanza, Bombiti. "Yield and quality of tomato as influenced by differential Ca, Mg and K nutrition." Diss., Pretoria : [s.n.], 2006. http://upetd.up.ac.za/thesis/available/etd-05152008-144742.
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Yamada, Shinichiro. "Small conductance Ca[2+]-dependent K[+] channels are the target of spike-induced Ca[2+] release in a feedback regulation of pyramidal cell excitability." Kyoto University, 2004. http://hdl.handle.net/2433/147511.
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Ivanovas, Aurimas. "Bioelementų (K, Na, Ca, Cl, Fe) kitimas nesportuojančių moterų kraujyje skirtingo dozuoto fizinio krūvio įtakoje." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2006. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2006~D_20060516_204730-79750.
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Summary
Bioelements are related with the main functions of organism: growth, development, reproduction, metabolism, are a part of bones, are important to oxygen transportation, to muscle contraction and etc. Bioelements as structural and functional components of biosubstrats, perform regulational function of different organs.
Topicality. There are many studies on different sports athletes about changes of bioelements while performing different physical activity. Physiological and biochemistry cathedral of Lithuanian academy of physical education has made a lot of studies on handball teams players, track and field athletes about changes of biolements while performing physical activity, but we still don‘t have information about fitness and aerobics exercise influence on changes of bioelements. It was interesting for us to study fitness and aerobics exercise influence on changes of bioelements (K, Na, Ca, Cl, Fe ).
Novelty. We don‘t have information how fitness and aerobics exercise influence of bioelements (K, Na, Ca, Cl, Fe ).changes in literaure.
Practical sense for sportsmens its very important to restore of water and saline balance . after the physical activity
Hypothesis. Body looses a lot of water and mineral salts while sweating, so we thought that different mineral salts concentration will appear in the venous blood of women who perform aerobic and fitness exercises.
The aim of the study is to determine the changes of bioelements (K, Na, Ca, Cl, Fe) in venous... [to full text]
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Kim, Tom Sang-Yong. "Topological organization, functional characterization and localization of the bovine rod photoreceptor Na/Ca-K exchanger." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0030/NQ38914.pdf.
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Khawaja, Farhan A. "Ca²+-dependent K+ currents and spike-frequency adaptation in medial entorhinal cortex layer II stellate cells." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101151.
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We hypothesized that stellate cells (SCs) from layer II of the medial entorhinal cortex (MEC) may express currents that underlie spike-frequency adaptation (SFA) and that inhibitory modulation of these currents may permit the non-adapting nature of pulse-evoked post-burst after-discharges, a possible neuronal correlate of the post-stimulus delay firing seen in-vivo during working memory (WM) tasks. It was revealed that SCs contain medium (mIK(Ca)) and slow (sIAHP) Ca2+-dependent K+ currents. Furthermore, it was determined that mIK(Ca) is not mediated by apamin-sensitive SK channels in SCs, whereas it was found to be is apamin-sensitive in MEC layer II non-SCs. In addition, the results indicated that mIK(Ca) and sIAHP may underlie SFA in SCs and that mIK(Ca), sIAHP and SFA are subject to inhibitory modulation by PKA-activation. Therefore, PKA modulation may be important for SCs to exhibit post-burst after-discharges. Future work is required to determine whether PKA modulation of MEC layer II SCs plays an important role during WM tasks.
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Cajazeira, João Paulo. "Crescimento e ecofisiologia de pitaias cultivadas em vasos submetidas a diferentes doses de k e ca." reponame:Repositório Institucional da UFC, 2016. http://www.repositorio.ufc.br/handle/riufc/21895.
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CAJAZEIRA, João Paulo. Crescimento e ecofisiologia de pitaias cultivadas em vasos submetidas a diferentes doses de k e Ca. 2016. 140 f. Tese (Doutorado em Fitotecnia)-Universidade Federal Ceará, Fortaleza, 2016.Submitted by Anderson Silva Pereira (anderson.pereiraaa@gmail.com) on 2017-02-03T20:16:19Z No. of bitstreams: 1 2016_tese_jpcajazeira.pdf: 2818803 bytes, checksum: 8dc8db1ed2fb700639006ddee1ca369c (MD5)
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It is obvious that the national agriculture has been changing rapidly in recent years. Given this, the culture of Dragon fruit has been shown in a viable alternative to farmers in the Northeast region. How do limiting factors include: the incipient information regarding mineral plant nutrition combined with growth data of culture (phenology). Developed a work in order to evaluate the influence of potassium and calcium in the development of white pitaya and its relationship to gas exchange and mineral characterization of their cladodes in the State of Ceará. The statistical design used was randomized blocks, in factorial 4 x 4, with 16 treatments and three replicates. The treatments were composed of potassium doses, with four levels (0, 125, 250 and 375 mg K dm-3) and doses of calcium, with four levels (0, 53, 106 and 159 mg Ca dm-3). The evaluations were conducted at two different times: 120 and 270 days for biometrics and 150 and 240 days for the evaluations of gas exchange. Photosynthetic pigments and chemical characterization of cladodes were carried out to 270 days. For the morphological characters, the nutritional interaction 375:53 mg dm-3 (K:CaO) was the one that stood out in the first 120 days, in the final step, the interaction that stood out was 250:159 mg dm-3 (K:Ca). Net photosynthesis was greater in the 125 mg dm-3 dose and 0 mg Ca dm-3. The photosynthetic pigments have excelled in the same doses of the 270-day assessment of biometrics. For the environmental conditions in which the test was conducted, the 250 and 159 mg dm-3 (K:Ca) doses were the ones that stood out. At the same time, in another work, the objective of evaluating the biometrics of the species Hylocereus undatus, sp. and Hylocereus setaceus in response to five doses of potassium, as well as to measure the content of this element in the tissues of these species of Cactus, grown in cladodes not rooted in pots of 11 dm-3. Initial growth was evaluated for each species separately (number of cladodes – NCL; sum of length of cladodes – SCC; diameter of cladodes – DCL; thickness of cladodes – ECL), as a function of time and doses of K in the form of chloride. In addition to the number of crow (NAU), length of root system (CSR), width of root system (LSR), fresh mass from the shoot (MFA) and aerial dry mass (MSA), comparing the species and those doses of K. For evaluation of initial growth variables, experimental design was used in DBC with four repetitions in subdivided plots, using as factors the doses of K (0, 80, 160, 240 and 320 mg dm-3) and time (180 and 270 days). About the other variables in the design was randomized blocks in factorial scheme 3x5, using as the species and referred to doses of K with factors. Among the initial growth measurements, there was an increase in values in relation to time, regardless of species. In the destructive measurements, the Hylocereus undatus presented the highest values being of 29.1 cm for root length, 16.2 cm for root width, 218.3 g for fresh pasta from aerial part and 36.8 g dry pasta aerial part. The biggest accumulation of K in the tissues of species, occurred in the Hylocereus setaceus, with values of 57.9 g kg-1 for cladodes and 5.8 g kg-1 in the roots. Therefore, under the conditions of the realization of research, in protected environment, the species that stood out morphologically was the H. undatus and chemically was the H. setaceus, being the intermediate Hylocereus sp. in all evaluations.
É notório que a agricultura nacional vem se modificando em ritmo acelerado nos últimos anos. Diante disso, a cultura da pitaia branca tem se mostrado uma alternativa viável a produtores agrícolas da região Nordeste. Como fatores limitantes, destacam-se: as incipientes informações em relação à nutrição mineral da planta, aliada a dados referentes ao crescimento da cultura (fenologia). Desenvolveu-se este trabalho visando avaliar a influência do potássio e cálcio no desenvolvimento da pitaia branca, bem como nas relações de trocas gasosas e caracterização mineral de seus cladódios, no estado do Ceará. O delineamento estatístico foi em blocos casualizados, em arranjo fatorial 4x4, com 16 tratamentos e três repetições. Os tratamentos foram constituídos por doses de potássio, (0, 125, 250 e 375 mg K dm-3) e doses de cálcio, (0, 53, 106 e 159 mg Ca dm-3). As avaliações foram realizadas em dois tempos distintos: 120 e 270 dias para as determinações biométricas e 150 e 240 dias para as avaliações de trocas gasosas. Os pigmentos fotossintéticos e a caracterização química dos cladódios foram realizados aos 270 dias. Para os caracteres morfológicos, a interação nutricional 375:53 mg dm-3 (K:Ca) foi a que se destacou nos primeiros 120 dias e, na etapa final, a interação que se destacou foi 250:159 mg dm-3 (K:Ca). A fotossíntese líquida foi maior nas doses 125 mg K dm-3 e 0 mg Ca dm-3. Os pigmentos fotossintéticos se destacaram nas mesmas doses da avaliação de 270 dias da biometria. Para as condições ambientais em que o ensaio foi realizado, as doses 250 e 159 mg dm-3(K:Ca) foram as que se destacaram. Paralelamente, em outro trabalho, objetivou-se avaliar a biometria das espécies Hylocereus undatus, Hylocereus sp. e Hylocereus setaceus, em resposta a cinco doses de potássio, além de mensurar o teor deste elemento nos tecidos destas espécies de cactáceas, cultivadas em cladódios não enraizados em vasos de 11 dm3. Avaliou-se o crescimento inicial para cada espécie isoladamente (número de cladódios – NCL; somatório do comprimento dos cladódios – SCC; diâmetro dos cladódios – DCL; espessura dos cladódios – ECL), em função do tempo e das doses de K na forma de cloreto. Além do número de auréola (NAU), comprimento do sistema radicular (CSR), largura do sistema radicular (LSR), massa fresca da parte aérea (MFA) e massa seca da parte aérea (MSA), comparando-se as espécies e as referidas doses de K. Para a avaliação das variáveis de crescimento inicial, utilizou-se o delineamento experimental em DBC com quatro repetições, no esquema de parcelas subdivididas, utilizando-se como fatores as doses de K (0, 80, 160, 240 e 320 mg dm-3) e o tempo (180 e 270 dias). Em relação às demais variáveis utilizou-se o delineamento em blocos casualizados no esquema fatorial 3x5, utilizando-se como fatores as espécies e as referidas doses de K. Dentre as medições de crescimento inicial, houve aumento nos valores em relação ao tempo, independentemente da espécie. Nas medições destrutivas, a pitaia branca apresentou os maiores valores, sendo de 29,1 cm para o comprimento radicular, 16,2 cm para a largura radicular, 218,3 g para a massa fresca da parte aérea e 36,8 g para a massa seca da parte aérea. O maior acúmulo de K nos tecidos das espécies ocorreu na pitaia do Cerrado, com valores de 57,9 g de K kg-1 para os cladódios e 5,8 g de K kg-1 nas raízes. Portanto, nas condições de realização da pesquisa, em ambiente protegido, a espécie que se destacou morfologicamente foi a pitaia branca e, quimicamente, foi a do Cerrado, sendo a vermelha intermediária em todas as avaliações.
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Leonel, Fernando de Paula. "Exigências em macronutrientes minerais (Ca, P, Mg, Na e K) para novilhos de diferentes grupos zootécnicos." Universidade Federal de Viçosa, 2003. http://www.locus.ufv.br/handle/123456789/11147.
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Fundação de Amparo a Pesquisa do Estado de Minas Gerais
O experimento foi realizado no Instituto Melon de Estudos e Pesquisas, Campus da Fazenda Barreiro LTDA, localizado no município de Silvânia, Estado de Goiás, com o objetivo de determinar as exigências em macronutrientes minerais (Ca, P, Mg, Na e K) para novilhos de diferentes grupos zootécnicos. Foram utilizados 44 novilhos não castrados, pertencentes a quatro grupos zootécnicos distintos: Nelore; F1 NelorexAberdeen-Angus; F1 NelorexPardo-Suíço e F1 NelorexSimental. Ao início dos trabalhos os novilhos encontravam-se numa faixa etária entre 10 e 11 meses e possuíam peso vivo médio de 362 + 35 kg. A ração experimental era constituída por feno de capim braquiária (Brachiaria decumbens, Stapf.), farelo de soja, milho (grão moído), melaço em pó e suplementados de macro e micronutrientes inorgânicos. As exigências líquidas, para ganho de peso, em cada macronutriente, foram obtidas por meio da derivada primeira de suas respectivas equações estimadas a partir da regressão do logaritmo do conteúdo do nutriente (Ca, P, Mg Na e K), em função do logaritmo do peso de corpo vazio do animal. Para a conversão dos pesos dos animais vivos em peso de corpo vazio, utilizou-se a equação obtida a partir da regressão do peso corporal vazio dos animais experimentais em função de seus pesos imediatamente antes do abate. As necessidades dietéticas dos macronutrientes, para mantença, foram estimadas de acordo com as recomendações dos americano e inglês (NRC e ARC), e os coeficientes de absorção adotados para os cinco macronutrientes foram aqueles propostos pelo sistema inglês (ARC). Por meio do teste de identidade de modelos não foram encontradas diferenças (P>0,05) entre as equações de regressão para os nutrientes cálcio, fósforo e potássio dentre os quatro grupos zootécnicos estudados, todavia foram detectadas diferenças entre as equações de regressão para o magnésio e o sódio. Foram verificadas pela análise de variância, diferenças entre as retenções do nutriente magnésio, em função dos distintos grupos zootécnicos (Teste F; p<0,05), e a retenção do nutriente magnésio no corpo dos animais dos grupos NelorexAberdeen-Angus e NelorexPardo-Suíço, não diferiu estatisticamente (Teste de Tukey; p<0,05). Por outro lado, essa retenção foi estatisticamente superior àquela dos animais dos grupos Nelore e NelorexSimental, que não diferiram entre si.
This experiment was conducted with the objective to determine the macro minerals requirements (Ca, P, Mg, Na and K) for yong bulls from different genetic groups. Forty four young bulls were used, from four different genetic groups: Nellore; F1 Nellore x Aberdeen-Angus; F1 Nellore x Brown Swiss and F1 Nellore x Simmental. The initial average live weight was 362 ± 35 kg and age between 10 and 11 months. The experimental ration was constituted by Brachiaria hay (Brachiaria decumbens, Stapf.), soybean meal, ground corn, powder molasses and macro and micro mineral premix. The net requirements of each macro mineral, for weight gains, were obtained by the first derived of their respective equations, estimated using the regression of the logarithm of the mineral content (Ca, P, Mg, Na, K), in function of the logarithm of the animal empty body weight. For the conversion of live weight to empty body weight of the animals, it was used the equation obtained from the regression of the empty body weight of the animals in function of their weights immediately before slaughter. The nutritional requirements of the macro minerals, for maintenance, were estimated based in that proposed by the American and British system (NRC and ARC), and the used absorption coefficients for the macro minerals xiwere from that proposed by British system (ARC). There were not differences between the regression equations for the macro minerals calcium, phosphorus and potassium among the four groups determined by the test of identity of models. However, it was detected differences between the regression equations for magnesium and sodium. There were differences among the retentions of the macro mineral magnesium in function of the genetic group (P<0.05). There was not difference in the retention of the macro mineral magnesium in the body of the animals from the Nellore x Aberdeen-Angus e Nellore x Brown Swiss (P<0.05). However, the retention was higher to that animals from the Nellore e Nellore x Simmental, that did not differ from each other.
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Stegen, Benjamin [Verfasser], and Stephan [Akademischer Betreuer] Huber. "Die Rolle von Ca 2+ -aktivierten K + -Kanälen für die Radioresistenz des Glioblastoms / Benjamin Stegen ; Betreuer: Stephan Huber." Tübingen : Universitätsbibliothek Tübingen, 2015. http://d-nb.info/1197693831/34.
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Mohanty, Basant Kumar. "A cytochemical study of the distribution of Na'+, K'+-ATPase and Ca'2'+-ATPase in Xenopus laevis oocytes." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281962.
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Ou, Jimmy W. "Large-conductance, voltage- and Ca²⁺ - sensitive K⁺ channels (maxiK) in astrocytes a novel intracellular interaction with the cytoskeleton /." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1835511491&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
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Nascimento, Yasmine ?sis Fernandes do. "Extra??o de metais (K, Mg, Ba, Ca, Cr, Mn, Li, Fe) de ?gua produzida utilizando sistema microemulsionado." Universidade Federal do Rio Grande do Norte, 2014. http://repositorio.ufrn.br:8080/jspui/handle/123456789/12990.
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Previous issue date: 2014-01-07Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior
The produced water is a byproduct formed due to production of petroleum and carries with it a high amount of contaminants such as oil particles in suspension, organic compounds and metals. Thus, these latter pollutants are very difficult to treat because of its high solubility in water. The objective of this work is to use and evaluate a microemulsioned system to remove metals ( K , Mg , Ba , Ca , Cr , Mn , Li , Fe ) of synthetic produced water. For the extraction of metals, it was used a pseudoternary diagram containing the following phases: synthetic produced water as the aqueous phase (AP), hexane as organic phase (OP), and a cosurfactant/surfactant ratio equal to four (C/S = 4) as the third phase, where the OCS (saponified coconut oil) was used as surfactant and n-butanol as cosurfactant. The synthetic produced water was prepared in a bench scale and the region of interest in the diagram for the removal of metals was determined by experimental design called. Ten points located in the phase Winsor II were selected in an area with a large amount of water and small amounts of reagents. The samples were analyzed in atomic absorption spectrometer, and the results were evaluated through a statistical assesment, allowing the efficiency analysis of the effects and their interactions. The results showed percentages of extraction above 90% for the metals manganese, iron, chromium, calcium, barium and magnesium, and around 45% for metals lithium and potassium. The optimal point for the simultaneous removal of metals was calculated using statistical artifact multiple response function (MR). This calculation showed that the point of greatest extraction of metals occurs was the J point, with the composition [72% AP, 9% OP, 19% C/S], obtaining a global extraction percentage about 80%. Considering the aspects analyzed, the microemulsioned system has shown itself to be an effective alternative in the extraction of metals on synthetic produced water remediation
A ?gua produzida ? um subproduto gerado na produ??o do petr?leo e possui uma grande quantidade de contaminantes, tais como part?culas de ?leo em suspens?o, compostos org?nicos e metais, sendo estes ?ltimos poluentes de dif?cil tratamento devido a sua alta solubilidade em ?gua. O objetivo deste trabalho ? utilizar e avaliar um sistema microemulsionado na extra??o de metais (K, Mg, Ba, Ca, Cr, Mn, Li, Fe) contidos na ?gua produzida. Utilizou-se um diagrama pseudotern?rio de um sistema contendo em sua composi??o: ?gua produzida sint?tica como fase aquosa (FA), hexano como fase org?nica (FO), e uma raz?o cotensoativo/tensoativo igual a quatro (C/T=4), sendo utilizado o OCS (?leo de coco saponificado) como tensoativo e n-butanol como cotensoativo. A ?gua produzida sint?tica foi preparada em escala de bancada e a regi?o de interesse para a remo??o dos metais foi determinada atrav?s do planejamento experimental de mistura, sendo escolhidos dez pontos localizados na fase de Winsor II, em uma ?rea com uma grande quantidade de ?gua e pouca quantidade de mat?ria ativa ou solvente. As amostras foram analisadas no espectr?metro de absor??o at?mica, e os resultados obtidos foram avaliados atrav?s de um tratamento estat?stico permitindo a an?lise da efici?ncia dos efeitos das vari?veis estudadas e suas intera??es. Os resultados apresentaram percentuais de extra??o acima de 90% para os metais mangan?s, ferro, cromo, c?lcio, b?rio e magn?sio, e em torno de 45% para o l?tio e o pot?ssio. O ponto ?timo para a remo??o simult?nea dos metais foi calculado atrav?s do recurso estat?stico de m?ltipla fun??o de resposta (MR). O c?lculo permitiu observar que o ponto onde ocorre o maior percentual de extra??o dos metais foi o ponto J com a composi??o [72% FA, 9% FO, 19% C/T], obtendo percentual de extra??o global em torno de 80% de todos os metais. Tendo em vista os aspectos analisados, o sistema microemulsionado estudado mostrou-se como uma eficiente alternativa na extra??o de metais de ?gua produzida sint?tica
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Diouri, Mouhsine. "Mise en évidence dans le muscle squelettique d'une Na⁺ ou K⁺-ATPase membranaire régulée par proteolyse Ca²⁺-dépendante." Bordeaux 1, 1989. http://www.theses.fr/1989BOR10533.
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Mise en evidence d'une activite atpeasique na⁺ ou k⁺-dependante dans les preparations de membrane plasmique du muscle strie. Une etude approfondie de cette atpase a permis de preciser qu'elle est insensible a l'ouabaine, et inhibee par l'acide ethacrynique et le vanadate. Elle est activee irreversiblement par les ions calcium. En presence de differents inhibiteurs de proteaases et notamment de luipeptine, d'antipaine et calpastatine. L'activation irreversible par les ions ca²⁺ peut etre induite par une thiolprotease ca²⁺-dependante analogue aux calpaines. D'ailleurs, une activite proteolytique ca²⁺-dependante correspondant a la calpaine i a pu etre mise en evidence apres traitement de ces memes membranes, a l'aide de differents detergents
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Ninomiya, Tomonori. "Verapamil, a Ca[2+] entry blocker, targets the pore-forming subunit of cardiac type K[ATP] channel (Kir6.2)." Kyoto University, 2004. http://hdl.handle.net/2433/147501.
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Cetin, Aysin. "Cfar Detection In K-distrbuted Sea Clutter." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/12609857/index.pdf.
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Conventional fixed threshold detectors set a fixed threshold based on the overall
statistical characteristics of the spatially uniform clutter over all ranges to give a
specific probability of false alarm and detection. However, in radar applications
clutter statistics are not known a priori. Constant False Alarm Rate (CFAR)
techniques provide an adaptive threshold to estimate the clutter statistics and to
distinguish targets from clutter. In Cell Averaging CFAR (CA-CFAR) the
threshold is controlled by averaging the fixed size CFAR cells surrounding the cell
under test.
In this thesis, radar detection of targets in sea clutter modelled by compound Kdistribution
is examined from a statistical detection viewpoint by Monte Carlo
simulations. The performance of CA-CFAR processors is analysed under varying
conditions of sea clutter spatial correlation and spikiness for several cases of false
alarm probability, the length of cell size used in the CFAR processor and the
number of pulses integrated prior to CA-CFAR processor.
v
The detection performance of CA-CFAR is compared with the performance of
fixed threshold detection. The performance evaluations are quantified by CFAR
loss. CFAR loss is defined as the increase in average signal to clutter ratio
compared to that of fixed threshold, required to achieve a given probability of
detection and probability of false alarm. Curves for CFAR loss to the spikiness and
spatial correlation of clutter, number of pulses integrated and the length of cell size
are presented.
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Wolkmer, Patricia. "Avaliações neuroquímicas, enzimáticas e comportamentais em ratos infectados experimentalmente com trypanosoma evansi e utilização da curcumina como possível agente terapêutico." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/4473.
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Conselho Nacional de Desenvolvimento Científico e TecnológicoThe pathogenesis of Trypanosoma evansi (T. evansi) infection on central and peripheral nervous system (CNS) and immunologic system it is not completely understood. This study was conducted to investigate the effects of infection by T. evansi on the behavioral performance of rats, relating them to neurochemical alterations of the glutamatergic system and activity of important enzymes such as Ca2 + ATPase, Na + / K + ATPase and acetylcholinesterase (AChE) in the brain. Furthermore, we evaluated the activity of AChE in the T. evansi, using a biochemical protocol and discussed some possibilities for the interaction between the presence of this enzyme in the parasite and its possible relation with the host. Also, we investigated the in vivo effect of curcumin as an antitrypanosomal agent to contribute in the search for new therapies. To this end, we conducted a series of studies, as follow that are presented as scientific articles: in the Article I are presented data from rats experimentally infected with T. evansi and in which the activity of AChE in total brain, cerebellum and blood and plasma butyrylcholinesterase activity on days 3 (T3) and 5 (T5) post infection (pi) were evaluated. In the Article II trypanosomes were isolated by Dietil Amino Etil-celulose column to perform enzymatic assays of AChE activity in the parasite. Article III presents the results of daily oral administration of Curcumin (20 or 60 mg / kg) as a preventive treatment (for 30 or 15 days pre-infection) or as curative treatment (for 15 days pi) for T. evansi infection in rats. The animals were evaluated for parasitemia, proinflammatory cytokines (IFN-γ, TNF-α, IL-1, IL-6) and anti-inflammatory (IL-10) in plasma. Also blood AChE activity was studied. In the manuscript I were evaluated behavioral changes (memory and anxiety), glutamate uptake, activity of AChE and ATPases (Ca +2 and Na +, K +) in brain structures of T. evansi infected rats (5 and 30 dpi). Together these studies suggest that rats infected with T. evansi have cognitive impairment, probably caused by changes on energy metabolism (ATPases) and in the cholinergic and glutamatergic systems. That way, alterations observed during behavioral tests probably indicate the progression of clinical disease as a result of neurochemical dysfunction. It was also demonstrated that it is possible to biochemically detect the AChE activity in the T. evansi and this could cause the hydrolysis of acetylcholine in the parasite. It was also demonstrated that pretreatment with curcumin induces immunomodulatory effects, altering inflammatory cytokines and activity of AChE in rats infected with T. evansi. The treatments reduced parasitic load and mortality. Therefore, curcumin should be considered as a feeding supplement in trypanosomiasis endemic areas.
Com este trabalho, buscou-se compreender os mecanismos da patogenia do Trypanosoma evansi no sistema nervoso central (SNC), periférico e imunológico. Para isso, foram avaliados os efeitos da infecção por T. evansi sobre o desempenho comportamental de ratos, relacionando-os com alterações neuroquímicas do sistema glutamatérgico e com as atividades de importantes enzimas cerebrais como a Ca+2ATPase, a Na+/K+ATPase e a acetilcolinesterase (AChE). Avaliou-se também, a atividade da AChE no T. evansi usando um protocolo de bioquímica, buscando discutir algumas possibilidades de interação entre a presença desta enzima no parasita e suas possíveis relações com o hospedeiro. Também, foi investigado o efeito in vivo da curcumina como agente tripanocida, a fim de contribuir na busca de novas terapias. Com estes propósitos, foram realizadas varios estudos, sendo: no artigo I buscou-se avaliar se a infecção pelo protozoário altera o sistema colinérgico. Para isso, foram utilizados ratos experimentalmente infectados com T. evansi e avaliada a atividade da AChE no cérebro total, no cerebelo e no sangue e a atividade da butirilcolinesterase plasmática nos dias 3 e 5 pós infecção (pi); no artigo II tripanossomas foram isolados por coluna de dietilaminoetilcelulose para realizar ensaios enzimáticos da atividade da AChE no parasito; no artigo III doses diárias de Curcumina (20 ou 60 mg / kg) diluída em óleo de milho foram administradas diariamente por via oral (gavagem) como tratamento preventivo (30 ou 15 dias pré-infecção) e como tratamento durante quinze dias pi. Os animais foram avaliados quanto a parasitemia, as citocinas pró-inflamatórias (IFN-γ, TNF-α, IL-1, IL-6) e anti-inflamatória (IL-10) plasmáticas e a atividade sanguínea da AChE; no manuscrito I foram avaliadas as alterações comportamentais (memória e ansiedade), a captação de glutamato, atividade da AChE e das ATPases (Ca +2 e Na +, K +) nas estruturas encefálicas nos dias 5 e 30 de ratos infectados com T. evansi. Com estes estudos, pode-se concluir que ratos infectados com T. evansi apresentam déficit cognitivo, provavelmente causados por alterações nos parâmetros do metabolismo energético (ATPases) e nos sistemas colinérgico e glutamatérgico, sugerindo que as alterações observadas durante testes comportamentais provavelmente indicam uma disfunção neuroquímica. Também foi demonstrado que é possível detectar bioquimicamente a atividade da AChE no T. evansi e esta deve ser responsável pela hidrólise da acetilcolina no parasita. Quando os animais infectados foram tratados com curcumina demonstrou-se que o pré-tratamento com este composto induz efeitos imunomodulatórios, alterando os parâmetros inflamatórios tais como as citocinas e a atividade da AChE sanguínea. Desta forma, sugere-se que a curcumina pode ser utilizada como um suplemento alimentar em áreas endêmicas de tripanossomíase, uma vez que reduziu a carga parasitária e a mortalidade em ratos infectados com T. evansi, contribuindo assim com novas alternativas de tratamento.
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Rainone, Raquel. "Avaliação de métodos analíticos para determinação de Na, K, Ca, Mg, P e S em biodiesel por ICP OES." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-28032012-104252/.
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Esse trabalho avaliou três diferentes procedimentos de preparo de amostra para determinação de Na, K, Ca, Mg, P e S em biodiesel por ICP OES. O primeiro procedimento avaliado foi uma modificação daquele proposto pela ANP para o controle da qualidade do biodiesel, onde a amostra foi introduzida diretamente no equipamento com e sem diluição em solvente orgânico (querosene ou xilol). Essa forma de preparo, apesar de ser bastante simples, apresentou interferências físicas graves que só puderam ser corrigidas com o uso de vaselina líquida nas soluções de calibração do equipamento para igualar a viscosidade às amostras e com o uso do carbono como padrão interno. O segundo método estudado baseou-se na introdução de biodiesel na forma de emulsão. Para esse caso, preparou-se emulsões contendo 500 mg de biodiesel, 1% m v-1 de Triton X-100 como agente emulsificante e 10% v v-1 de ácido nítrico, misturados com água ultra-pura até o volume final de 10 mL. Esse método de preparo foi bastante simples e eliminou as grandes dificuldades de se trabalhar com solução orgânica no plasma. No entanto, o agente emulsificante apresentou elevadas concentrações de alguns dos analitos, aumentando o sinal dos brancos, além de gerar resultados com altos desvios padrões. O terceiro método foi a digestão das amostras usando aquecimento assistido por micro-ondas. Esse método eliminou quase que completamente a matriz orgânica, gerando os menores limites de detecção e tornou a introdução da amostra no equipamento mais fácil. Contudo, o tempo de preparo da amostra para o método da digestão, assim como os custos associados a este método, foram os maiores obtidos em relação aos outros. Outro ponto negativo foi e elevado fator de diluição desse método que dificultou a detecção dos analitos. Testes de adição e recuperação de analitos foram realizados nos três métodos e os resultados obtidos nos três casos ficaram dentro da faixa considerada satisfatória de 80 a 120% de recuperação. Ao final do desenvolvimento, 7 amostras foram analisadas pelos três métodos e seus resultados comparados. Em certos casos, a comparação foi dificultada pelo grande número de resultados abaixo dos limites de detecção. No entanto, pôde-se observar que, com exceção do S, os resultados obtidos pelos diferentes métodos não apresentaram boa concordância entre si. Entretanto, devido à falta de material certificado, não se pode avaliar qual método seria o mais exato. Todavia, considerando-se o preparo mais simples e com a menor taxa de diluição, a análise de biodiesel puro (100%), com o uso do carbono como padrão interno foi considerado o método com resultados mais confiáveis.The present work has evaluated three different sample preparation methods for determination of Na, K, Ca, Mg, P and S in Biodiesel by ICP OES. The first one was similar to the method required by ANP for Biodiesel quality control, based on the introduction of organic samples into the ICP. In this case, the samples were analyzed with and without dilution in organic solvents (kerosene or xylol). Even though this sample preparation procedure has shown to be very simple, the physical interferences observed were severe and required the use of two different strategies to be overcome: addition of high viscosity oil (vaseline) to the calibration solutions and carbon as internal standard. The second method was based on the introduction of Biodiesel emulsion into the ICP. These emulsions were prepared by the addition of 500 mg of sample, 1% w v-1 Triton X-100 as emulsifying agent and 10% v v-1 of nitric acid in ultrapure water up to 10 mL of final volume. Although this simple sample preparation method has eliminated the challenges associated with the use of organic solvents, the blank solution presented a high concentration of some analytes, due to the contamination by the emulsifying agent and this method generated results with high blank signal and standard deviation. The third method was based on microwave assisted digestion of Biodiesel samples. This method was the only one capable of eliminating the organic matrix and all the challenges associated with it, which made the sample introduction easier and improved the method detection limits. Nevertheless, the time consumed in this sample preparation was higher than in the other cases, as also were the associated costs of analysis. The dilution factor was also very high, making difficult the detection of the analytes. The spike recoveries obtained for each method were in the range of 80 to 120%, which were considered satisfactory. Seven different samples were analyzed by each method, but the comparison of the results was difficult because many results were lower than the detection limits. Even though, it was possible to conclude that the concentrations obtained in each method were very different for all elements, excluding S. Without a certified reference material, it was not possible to point out which results were more exact, but considering the simpler sample preparation procedure, with the lower dilution factor, we concluded that the direct analysis of Biodiesel 100%, using carbon as an internal standard was the method that presented more reliable results
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Deon, Magnus Dall'Igna. "Crescimento e nutrição mineral da soja submetida a excesso de P, S, K, Ca e Mg em solução nutritiva." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/11/11140/tde-19072007-094401/.
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Um sistema de cultivo eficiente depende do correto manejo da nutrição das plantas. Desordens nutricionais podem ser induzidas por manejo da fertilização inadequada e excessiva, dentre elas toxidez e deficiência induzida de um nutriente por outro. Com o objetivo de avaliar o comportamento da soja cultivar CD-208 ao excesso de cinco macronutrientes em solução nutritiva, foi realizado um experimento em casa de vegetação. Os tratamentos constituíram-se de um controle baseado na solução nutritiva de Hoagland e Arnon (1950) e soluções nutritivas iguais a essa, com a adição de 1,5; 3,0; 4,5 e 6,0 mmolc L-1 de um dos dois ânions (H2PO4 - e SO4 -2) acompanhado da mesma molaridade de carga de cada um dos três cátions (K+, Ca+2 e Mg+2). O único nutriente que provocou toxidez às plantas foi o fósforo, acumulando-se nas folhas diagnósticas em concentrações de até 12,8 g kg-1. Sob essa condição de toxidez, as plantas apresentaram clorose amarelo-amarronzada internerval nas folhas velhas que progrediu para necrose e abscisão, e acumularam menos massa seca, sofrendo alteração da relação entre parte aérea e raízes. Também apresentaram teores maiores de nitrogênio, enxofre e potássio, resultante da concentração destes nutrientes com a diminuição da massa seca e diminuição do teor de magnésio. Potássio e magnésio tiveram a concentração foliar aumentada pela sua maior concentração na solução, diferentemente do cálcio. A concentração foliar de cálcio foi menor com maiores concentrações de potássio e magnésio na solução nutritiva, mas potássio e magnésio não sofreram redução na concentração foliar com o aumento de outros cátions na solução. As mais altas concentrações de potássio na solução resultaram em menor concentração de ferro nos tecidos. O aumento na concentração de fósforo na solução nutritiva resultou na diminuição da concentração de cobre, mas não da concentração de zinco nas folhas diagnósticas.An effective cultivation system depends on the adequate management of plant nutrition. Nutritional disorders may be induced by inadequate and excessive fertilization, and toxicity and deficiency may be induced by one nutrient on another. A greenhouse experiment was performed aiming to evaluate the behavior of the soybean cultivar CD- 208 to excess of five macronutrients in nutrient solution. Treatments were a control based on the Hoagland and Arnon (1950) nutrient solution and similar solutions with the addition of 1.5, 3.0, 4.5 and 6.0 mmolc L-1 of the anions H2PO4 -or SO4 -2 and the same molarity charge of each of the cations K+, Ca+2 and Mg+2. The only nutrient that caused toxicity to the plants was phosphorus, which accumulated in the diagnostic leaves in concentrations up to 12.8 g kg-1. Under this condition of toxicity, plants presented a yellow-brownish interveinal chlorosis in the old leaves which progressed to necrosis and abscission, and accumulated less dry mass, modifying the shoot:root ratio. The leaves also presented higher nitrogen, sulfur and potassium content due to concentration effect as dry matter diminished, and lower magnesium content than the control plants. Potassium and magnesium had their leaf concentration increased by its higher concentration in the solution; the same doesn't happen with calcium. High magnesium and potassium rates significantly decreased calcium content in the leaves. However, potassium and magnesium concentrations were not influenced by increasing concentration of others cations in the nutrient solution. There was a decrease in the content of iron with increasing potassium concentration in the solution culture. High phosphorus rates in nutrient solution decreased copper content in leaves, but did not decrease zinc content.
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Oliva, Carlos Alfredo Calpa [UNESP]. "Hemograma e teores séricos de Na, K, Mg, Ca e P de cães hígidos submetidos à administração de cisplatina." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/89087.
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oliva_cac_me_jabo.pdf: 178983 bytes, checksum: f310a85e1eb63818fa51dba6cafeadd8 (MD5)A cisplatina é um fármaco antineoplásico utilizado como adjuvante no tratamento de diversas neoplasias. Neste estudo foram avaliados o hemograma e os teores de sódio, potássio, magnésio, cálcio e fósforo do soro sanguíneo de cães submetidos à terapia com cisplatina. Foram utilizados oito cães, machos, sem raça definida, com 10 a 15 kg de peso, clinicamente sadios. Os cães foram distribuídos em dois grupos, contendo 4 animais cada, sendo que os animais do grupo 1 receberam cisplatina e aqueles do grupo 2 não receberam cisplatina. Os cães do grupo 1 receberam quimioterapia e protocolo de diurese para proteção renal, já o grupo controle 2 não recebeu a cisplatina, estando sujeito apenas aos fatores ambientais. Os animais do grupo 1 foram submetidos a quatro sessões de quimioterapia com cisplatina na dose de 70mg/mø, administrada por via intravenosa, durante 20 minutos, no intervalo de 21 dias. Antes da administração da cisplatina, realizou-se fluidoterapia com solução fisiológica a 0,9% na dose de 25mL/kg/hora, por via intravenosa, durante duas horas, e depois por mais uma hora. Todos os animais receberam metoclopramida na dose de 2mg/kg, por via intravenosa, 15 minutos antes da administração da cisplatina e furosemida na dose de 2 mg/kg, por via intravenosa, 5 minutos após administração de metoclopramida. As amostras foram processadas e analisadas antes de cada sessão de quimioterapia. Os resultados mostraram que não houve diferença significativa entre os grupos para as contagens de hemácias, concentração de hemoglobina, hematócrito e contagem de leucócitos, mesmo assim as concentrações séricas de eletrólitos mantiveram-se dentro dos padrões da normalidade. Os resultados obtidos podem ser indicativos de que o protocolo empregado para o grupo 1 se mostrou efetivo para manter as características do hemograma e a concentração sérica dos eletrólitos.
The cisplatin is an antineoplasic drug used like adjunct treatment of various neoplasms. In this study, one evaluated the hemogram and sodium, potassium, magnesium, calcium and phosphorus levels in the dogs` blood under administration of cisplatin. One used 8 male dogs, with no definite race, weighing from 10 to 15 kilograms, and clinically healthy. The dogs were divided into two groups of 4 animals each, being group 1 treated with cisplatin and group 2 with no cisplatin. Group 1 received chemotherapy and the diurese protocol for kidney protection, group 2 did not receive cisplatin, being exposed only to the environmental factors. The animals from group 1 were submitted to four chemotherapy sessions with cisplatin 70mg/m2 administered intravenously for 20 minutes, in a 21 days interval before the cisplatin administration, one carried out a fluidotherapy with physiologic solution 0,9% on a dosage of 25mg/kg/hour intravenously during 2 hours, and posteriorly for one more hour. All the animals received methoclopramid intravenously on a dosage of 2mg/kg, 15 minutes before the cisplatin and furosemide administration on a 2mg/kg dosage, 5 minutes before the cisplatin infusion. The evaluation of the hemogram and the electrolytes levels above mentioned were done before each chemotherapy session. The results demonstrate that there were no significant differences among the groups for red blood cells counting, hemoglobin concentration, hematocrit and leucocytes counting, but still, the electrolytes seric concentration maintained itself in a normal standard. The results obtained may indicate that the protocol employed for group 1 showed efficiency to maintain the characteristics of the hemogram and the electrolytes seric concentration.
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Oliva, Carlos Alfredo Calpa. "Hemograma e teores séricos de Na, K, Mg, Ca e P de cães hígidos submetidos à administração de cisplatina /." Jaboticabal : [s.n.], 2007. http://hdl.handle.net/11449/89087.
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Orientador: Carlos Roberto DaleckBanca: José Jurandir Fagliari
Banca: Duvaldo Eurides
Resumo: A cisplatina é um fármaco antineoplásico utilizado como adjuvante no tratamento de diversas neoplasias. Neste estudo foram avaliados o hemograma e os teores de sódio, potássio, magnésio, cálcio e fósforo do soro sanguíneo de cães submetidos à terapia com cisplatina. Foram utilizados oito cães, machos, sem raça definida, com 10 a 15 kg de peso, clinicamente sadios. Os cães foram distribuídos em dois grupos, contendo 4 animais cada, sendo que os animais do grupo 1 receberam cisplatina e aqueles do grupo 2 não receberam cisplatina. Os cães do grupo 1 receberam quimioterapia e protocolo de diurese para proteção renal, já o grupo controle 2 não recebeu a cisplatina, estando sujeito apenas aos fatores ambientais. Os animais do grupo 1 foram submetidos a quatro sessões de quimioterapia com cisplatina na dose de 70mg/mø, administrada por via intravenosa, durante 20 minutos, no intervalo de 21 dias. Antes da administração da cisplatina, realizou-se fluidoterapia com solução fisiológica a 0,9% na dose de 25mL/kg/hora, por via intravenosa, durante duas horas, e depois por mais uma hora. Todos os animais receberam metoclopramida na dose de 2mg/kg, por via intravenosa, 15 minutos antes da administração da cisplatina e furosemida na dose de 2 mg/kg, por via intravenosa, 5 minutos após administração de metoclopramida. As amostras foram processadas e analisadas antes de cada sessão de quimioterapia. Os resultados mostraram que não houve diferença significativa entre os grupos para as contagens de hemácias, concentração de hemoglobina, hematócrito e contagem de leucócitos, mesmo assim as concentrações séricas de eletrólitos mantiveram-se dentro dos padrões da normalidade. Os resultados obtidos podem ser indicativos de que o protocolo empregado para o grupo 1 se mostrou efetivo para manter as características do hemograma e a concentração sérica dos eletrólitos.
Abstract: The cisplatin is an antineoplasic drug used like adjunct treatment of various neoplasms. In this study, one evaluated the hemogram and sodium, potassium, magnesium, calcium and phosphorus levels in the dogs' blood under administration of cisplatin. One used 8 male dogs, with no definite race, weighing from 10 to 15 kilograms, and clinically healthy. The dogs were divided into two groups of 4 animals each, being group 1 treated with cisplatin and group 2 with no cisplatin. Group 1 received chemotherapy and the diurese protocol for kidney protection, group 2 did not receive cisplatin, being exposed only to the environmental factors. The animals from group 1 were submitted to four chemotherapy sessions with cisplatin 70mg/m2 administered intravenously for 20 minutes, in a 21 days interval before the cisplatin administration, one carried out a fluidotherapy with physiologic solution 0,9% on a dosage of 25mg/kg/hour intravenously during 2 hours, and posteriorly for one more hour. All the animals received methoclopramid intravenously on a dosage of 2mg/kg, 15 minutes before the cisplatin and furosemide administration on a 2mg/kg dosage, 5 minutes before the cisplatin infusion. The evaluation of the hemogram and the electrolytes levels above mentioned were done before each chemotherapy session. The results demonstrate that there were no significant differences among the groups for red blood cells counting, hemoglobin concentration, hematocrit and leucocytes counting, but still, the electrolytes seric concentration maintained itself in a normal standard. The results obtained may indicate that the protocol employed for group 1 showed efficiency to maintain the characteristics of the hemogram and the electrolytes seric concentration.
Mestre
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Marchand, Sylvie. "Étude théorique de la coopérativité dans la liaison des ions Ca²§+ aux sites de la calbindine D¦9[indice]k." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ35616.pdf.
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Lüdders, Dörte Wiebke. "Einfluss des Phosphodiesterase-Typ-5 Inhibitors Sildenafil auf den Ca 2+ -aktivierten K + -Kanal mit großer Leitfähigkeit in humanen Endothelzellen." Giessen : VVB Laufersweiler, 2007. http://geb.uni-giessen.de/geb/volltexte/2007/4536/index.html.
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Storck, Hannah [Verfasser], and Albrecht [Akademischer Betreuer] Schwab. "Einfluss des Calcium-aktivierten Kalium-Kanals K Ca 3.1 auf die Migration von Pankreas-Sternzellen / Hannah Storck ; Betreuer: Albrecht Schwab." Münster : Universitäts- und Landesbibliothek Münster, 2014. http://d-nb.info/1138280917/34.
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Hashiguchi(Ikeda), Mitsuko. "Halothane inhibits an intermediate conductance Ca[2+]-activated K[+] channel by acting at the extracellular side of the ionic pore." Kyoto University, 2004. http://hdl.handle.net/2433/145289.
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Dumoulin, Marc. "Activation des canaux K§+ dépendants du Ca²§+ par l'acide époxyeicosatrienoïque et son rôle en physiologie des muscles lisses des voies respiratoires." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0007/MQ40577.pdf.
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Lourenço, Emilene de Carvalho. "Desenvolvimento de método empregando microextração líquido-líquido dispersiva em fase reversa para determinação de Na, K, Ca e Mg em biodiesel." Universidade Tecnológica Federal do Paraná, 2016. http://repositorio.utfpr.edu.br/jspui/handle/1/2935.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Neste trabalho foi desenvolvido um método empregando a técnica de microextração líquido-líquido dispersiva em fase reversa (RP-DLLME) como preparo de amostra, para extração e pré-concentração de Na, K, Ca e Mg em amostras de biodiesel. A determinação dos analitos foi feita por espectrometria de absorção atômica com chama (F AAS), operando no modo emissão para Na e K e absorção para Ca e Mg. Para executar a etapa de extração/pré-concentração dos analitos empregou-se uma mistura de dois solventes, um dispersor e um extrator, que foi adicionada em cada amostra em volumes e concentrações adequados. A extração dos analitos ocorreu após adição da mistura de dispersor-extrator e a fase sedimentada formou-se mediante centrifugação. Foram avaliados alguns parâmetros sobre a eficiência da extração como: massa de amostra (3, 5, 10 e 20 g), tipos de solvente dispersor e proporção (isopropanol, 60, 65, 70, 75, 80, 85% (v/v)), concentração da solução extratora (HNO3 0,5; 1; 1,5 e 2 mol L-1 (v/v)), volume da fase extratora (0,5; 1,0 ; 1,5 e 2 mL), tempo de centrifugação (5, 10 e 15 min) e temperatura (45, 55, 65 e 75 °C). Para todos os parâmetros avaliados e ajustados, foi feita a adição dos analitos (1,0 μg) nas amostras com dois padrões multielementares de biodiesel (2,5 e 20 μg g-1 de Na, K, Ca e Mg), sendo os resultados expressos como recuperação (%). Para a determinação dos analitos por F AAS, foi feita calibração externa com soluções de referência aquosas. As curvas de calibração para Na, K, Ca e Mg foram lineares entre 0,1 e 2,0 mg L-1 Os limites de quantificação para Na, K, Ca e Mg para este método foram 0,04; 0,02; 0,05 e 0,08 mg kg-1, respectivamente. A exatidão foi avaliada por meio de ensaios de recuperação e os valores obtidos entre 94 e 108% com RSD inferior a 5% para todos os analitos. O método foi aplicado a cinco amostras diferentes de biodiesel produzidos a partir de diferentes matérias-primas. O método desenvolvido foi considerado viável para a determinação de Na, K, Ca e Mg em biodiesel, atendendo os requisitos da Legislação Brasileira, que determina limites máximos de 5 mg k-1 para a soma de Na e K e o mesmo limite para a soma de Ca e Mg. Como principais aspectos que caracterizam o método, destaca-se a simplicidade de operação, o baixo custo, baixo consumo de reagentes de acordo com os princípios da Química Verde, uso de equipamentos de fácil operação, alta frequência analítica, além de baixos limites de quantificação para determinação dos analitos por F AAS.
This research developed a method for employing reversed-phase dispersive liquid-liquid microextraction (RP-DLLME) as sample preparation for the extraction and pre-concentration of Na, K, Ca and Mg in biodiesel samples. The determination of analytes were executed through flame atomic absorption spectrometry (F AAS), operating in emission mode for Na and K and absorption mode for Ca and Mg. The extraction/pre-concentration step of the analytes was performed using a mixture of two solutions, a dispersing and an extractor, which were added to each sample in appropriate volumes and concentrations. The extraction of analytes occurred after the addition of the dispersing-extractor settled-phase mixture formed via centrifugation. Some parameters were evaluated on the extraction efficiency, such as: sample mass (3, 5, 10 and 20 g), different kinds of dispersant solvent and proportion (isopropanol, 60, 65, 70, 75, 80, 85% (v/v)), concentration of the extraction solution (HNO3 0,5; 1;1,5 and 2 mol L-1 (v/v)), the volume of extraction phase (0.5; 1.0; 1.5 and 2.0 mL), centrifugation time (5, 10 and 15 min) and temperature (45, 55, 65 and 75 °C). All the studied and adjusted parameters were made by analytes addition (1.0 μg) on the samples with two biodiesel multielemental standards (2.5 and 20 μg g-1 Na, K, Ca and Mg) whose results were expressed in recovery percentage (%). Due to the determination of analytes by F AAS, an external calibration was performed with aqueous reference solution. The calibration curves for Na, K, Ca and Mg were linear between 0.1 and 2.0 mg L-1. The quantification limits of Na, K, Ca and Mg for this method were respectively: 0.04; 0.02; 0.05 and 0.08 mg kg-1. The accuracy of the proposed method was assessed by recovery experiments and the values obtained were between 94% and 108% with RSD less than 5% for all analytes. The developed method was then applied to five different samples of biodiesel produced from different raw materials. Hence, the developed method was considered viable for the determination of Na, K, Ca and Mg in biodiesel, in accordance with the requirements of Brazilian regulation, which sets maximum limits of 5 mg k-1 for adding Na and K and the same limit for adding Ca and Mg. The main aspects that characterize this method are its simplicity in operation, low cost, low consumption of reagents according to the principles of green chemistry, easy operation equipment use, high analytical frequency, and low limits of quantification for the determination of analytes for F AAS.
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Martins, Renè Galvão Rezende. "Exigências de energia, proteína e macroelementos minerais (Ca, P, Na, K, Mg) de bovinos Nelore e mestiços, não castrados, em confinamento." Universidade Federal de Viçosa, 2003. http://www.locus.ufv.br/handle/123456789/11192.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Avaliaram-se as exigências de energia, proteína e macroelementos minerais (Ca, P, Na, K e Mg) em animais de três grupos genéticos, Nelore, 1⁄2 Caracu e 1⁄2 Holandês, em confinamento. Foram utilizados 48 bovinos não castrados, sendo 24 animais na categoria recria e 24 animais na categoria terminação. Foram alimentados com uma dieta à base de 50% de concentrado e 50% de silagem pré- secada de capim tifton, no primeiro período, e de capim braquiaria, no segundo, na base da matéria seca. Quatro animais de cada grupo genético foram abatidos e serviram como referência no estudo da composição corporal e exigências nutricionais, enquanto outros quatro animais de cada grupo foram alimentados ao nível de mantença. Os animais da fase recria apresentaram peso inicial médio de 230kg e foram abatidos após atingirem peso vivo entre 310 e 330 kg. Os animais da fase de terminação apresentaram peso inicial médio de 328kg e foram abatidos após atingirem peso vivo ente 450 e 480 kg. Os animais foram pesados no início do experimento e, periodicamente, a cada 28 dias. Foram colhidas amostras de órgãos, vísceras, sangue, couro, cauda, cabeça, pés e carcaça. A relação obtida entre o peso de corpo vazio (PCVZ) e o peso vivo (PV) dos animais referência foi utilizada para a estimativa do PCVZ inicial dos animais que permaneceram no experimento. Os conteúdos de gordura, proteína, energia e macroelementos minerais (Ca, P, Na, K e Mg) retidos no corpo dos animais foram estimados por meio de equações de regressão do logaritmo do conteúdo corporal de proteína, gordura, energia, Ca, P, Na, K ou Mg, em função do logaritmo do PCVZ. A exigência de energia líquida para mantença (ELm), foi estimada pelo intercepto da regressão linear entre o logaritmo da produção de calor (PC, em Kcal/kg 0,75 /dia) e o consumo de energia metabolizável (CEM, em Kcal/kg 0,75 /dia). O teste para verificação da identidade de modelos indicou haver diferença entre animais Neloreviii e mestiços para os conteúdos de gordura, energia, cálcio e fósforo. Obteve-se o fator 0,935 para conversão das exigências de quilograma de peso de corpo vazio em quilograma de peso vivo. A equação para determinação do peso de corpo vazio a partir do peso vivo obtida foi: PCVZ = 0,873*PV. O valor obtido de ELm foi 82,37 Kcal/kg 0,75 /dia. Para animais entre 200 e 500 kg PV, os conteúdos corporais de proteína por quilograma de peso de corpo vazio reduziram à medida em que se elevou o peso vivo. Os conteúdos corporais de gordura e energia por quilograma de peso de corpo vazio aumentaram com a elevação do peso vivo. Observaram- se maiores concentrações de gordura e energia, e menores concentrações de proteína, em animais Nelore que mestiços. Da mesma forma, foram observadas maiores exigências de energia para ganho por animais Nelore que por mestiços. Para animais entre 200 e 500 kg PV, as exigências de energia metabolizável variaram de 13,0 a 22,2 Mcal/dia para animais Nelore e 12,4 a 21,0 Mcal/dia para animais mestiços. As exigências de proteína metabolizável de Nelore foram superiores à dos mestiços. A concentração de cálcio e fósforo (g/kg PCVZ) aumentou à medida que o peso vivo se elevou, somente para os animais Nelore. A concentração de sódio e potássio nos animais mestiços diminuiu com o aumento do PV. O magnésio não sofreu redução de sua concentração para nenhum dos grupos. Os animais Nelore apresentaram maiores exigências, por kg de ganho de PV, de Ca, P, Na e K que os Mestiços. Em relação ao Mg foi observado o contrário; ou seja, maiores exigências em animais Mestiços que em Nelore. Observaram-se maiores exigências dietéticas totais de Ca e P por animais Nelore que Mestiços. As exigências dietéticas totais de Na e K foram semelhantes entre mestiços e Nelore. Quanto ao Mg, os animais Mestiços apresentaram maior exigência dietética total que os Nelore.
The requirements of energy, protein and minerals (Ca, P, Na, K, Mg) in animals of three genetic groups – Nellore, 1⁄2 Caracu, and 1⁄2 Holstein – in confinement, were evaluated. Forty-eight bulls were used: 24 in the growing category, and 24 in the fattening category. They had a diet based on 50% of concentrated and 50% tifton grass silage during the first phase and brachiaria grass during the second phase. Four animals from each genetic group were slaughtered, and were taken as reference to study the body composition and nutritional requirements. Meantime, another four animals of each group were fed for maintenance. The animals were weight in the beginning of the experiment and, then, periodically, every 28 days. Samples were obtained: organs, viscera, blood, leather, tail, head and carcass. The relation between the empty body weight (EBW) and the live weight (LW) of these animals was used to estimate the initial EBW of the animals remaining in the experiment. The levels of fat, protein, energy and minerals (Ca, P, Na, K, Mg) retained in the body of the animals were evaluated using equations of logarithm regression of the body contents of protein, fat, energy, Ca, P, Na, K or Mg, related to EBW logarithm. The net energy requirement for maintenance (Elm) was estimated by interception of linear regression between the logarithm of heat production ( PC, in Kcal/Kg 0,75 /d) and the consumption of metabolizable energy (MEC, in Kcal/Kg 0,75 /d). The test to verify the identity of the models indicated the presence of some differences between Nellore and crossbred animals, as far as fat, energy, calcium and phosphor. Factor 0,935 was obtained to convert the requirements for gain of empty body weight into gain of live weight. The equation to determine the empty body weight based on the live weight was: EBW = 0,873 * LW. The result of Elm was 82,37 Kcal/Kg 0,75 /d. The animals between 200 and 500 LW had the body contents of protein per Kg of empty body weight reduced, at thex same time that live weight increased. The body contents of fat and energy per Kg of empty body weight increased along with the live weight. There were more fat and energy concentrations, and less protein concentrations in Nellore rather than in crossbred animals. There were also more energy requirements by Nellore than by crossbred. For the animals between 200 and 500 Kg LW, the metabolizable energy requirements ranged from 13,0 to 22,2 Mcal/day for Nellore, and from 12,4 to 21,0 Mcal/day for crossbred. The concentration of calcium and phosphor (g/Kg EBW) increased along with the live body, only for Nellore. The concentration of sodium and potassium in crossbred animals decreased with the increase of LW. Magnesium didn’t have any concentration reduction in the 2 groups. Nellore animals had more requirements than crossbred, as far as gaining weight, Ca, P, Na, K. The opposite was observed concerning Mg: more requirements in crossbred than in Nellore. There were more total dietary requirements of Ca and P in Nellore than in crossbred. Na and K dietary requirements were similar in both groups, and Mg dietary was higher in crossbred than in Nellore.
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Fujioka, Yasutada. "Interaction of Na^{+}-K^{+} pump and Na^{+}-Ca^{+} exchange via [Na^{+}]i in a restricted space of guinea-pig ventricular cells." Kyoto University, 1999. http://hdl.handle.net/2433/181738.
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Gafeira, Ricardo Jorge Maranhas [Verfasser], Sami K. [Akademischer Betreuer] Solanki, Sami K. [Gutachter] Solanki, Laurent [Gutachter] Gizon, Hardi [Gutachter] Peter, Jens [Gutachter] Niemeyer, Wolfram [Gutachter] Kollatschny, and Ariane [Gutachter] Frey. "Slender Ca II H fibrils observed by SUNRISE/SuFI / Ricardo Jorge Maranhas Gafeira ; Gutachter: Sami K. Solanki, Laurent Gizon, Hardi Peter, Jens Niemeyer, Wolfram Kollatschny, Ariane Frey ; Betreuer: Sami K. Solanki." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2018. http://d-nb.info/115678008X/34.
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Svensson, Richard. "Determination of Al, Ca, Fe, K, Mg, P and Na in soil by ICP-AES and method validation of the AL-method." Thesis, Uppsala universitet, Institutionen för kemi - BMC, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-325279.
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Schneider, Juliane [Verfasser]. "Expression des small conductance Ca²+ activated K+ channel (SK3) im invasiven Urothelkarzinom der Harnblase und Korrelation mit klinischen und histopathologischen Tumormerkmalen / Juliane Schneider." Ulm : Universität Ulm, 2017. http://d-nb.info/1136370110/34.
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Sowerby, Anna. "An investigation of the properties of large-conductance Ca^2+-activated K^+ channels of rat arterial smooth muscle and their modulation by vasoconstrictors." Thesis, University of Leicester, 2009. http://hdl.handle.net/2381/4803.
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Large-conductance Ca^2+ -activated K^+ (BKCa) channels play an important role in the regulation of vascular tone. They are activated by membrane depolarization and increases in local Ca^2+ concentration ([Ca^2+]). Their location in the plasma membrane allows them to be activated by transient releases of Ca^2+ from ryanodine receptors (RyR) in the sarcoplasmic reticulum, termed Ca^2+ sparks, leading to the efflux of K^+ known as a spontaneous transient outward current (STOC). Activation of BKCa channels in this manner provides a negative feedback mechanism to regulate vasoconstriction by hyperpolarizing the cell membrane and so reducing Ca^2+ influx through L-type voltage dependent Ca2+ channels. In this thesis I have investigated the relationship between [Ca^2+]i and membrane potential using inside-out patches excised from smooth muscle cells isolated from rat mesenteric artery. Whole-cell BKCa currents in these cells were also investigated both in the form of STOCs and by using voltage pulses to activate BKCa channels. The effects of the vasoconstrictors endothelin-1 (ET- 1) and angiotensin II (Ang II) on both pulse-induced BKCa currents and STOC amplitude and frequency were investigated. Single BKCa channels with a slope conductance of 189 pA were recorded and their activation was shown to be dependent on [Ca^2+]i and membrane potential. Membrane depolarization also increased BKCa whole-cell current and the frequency and amplitude of STOCs. ET-1 and Ang II were found to inhibit pulse-induced BKCa currents and this effect of ET-1 could be inhibited using a peptide PKC inhibitor. ET-1 and Ang II also caused a decrease in both STOC amplitude and frequency, although the decrease in frequency may be the result of the reduction in amplitude. Finally, 1, 2-dioctanoyl-sn-glycerol (DOG), an analogue of the endogenous PKC activator diacylglycerol (DAG), was seen to inhibit both BKCa whole-cell and single channel currents, possibly due to direct inhibition of BKCa channels.
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Baus, Picard Jorge. "L'Accumulation des cations (K. Ca. Mg. Na et Fe) et l'adaptation de Dittrichia (ex inula) viscosa W. Greuter aux sols acides et calcaires." Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb37595770c.
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Schimmelpfennig, Irene. "Cosmogenic [36]Cl in Ca and K rich minerals : analytical developments, production rate calibrations and cross calibration with [3]He and [21]Ne." Aix-Marseille 3, 2009. https://tel.archives-ouvertes.fr/tel-00468337.
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Les taux de production du nucléide cosmogénique [36]Cl par spoliation du Ca et du K (SLHL) proposés actuellement dans la littérature montrent des divergences allant jusqu'à 50% (e. G. Gosse and Phillips, 2001). Nous avons pu montrer que des fortes teneurs en Cl dans les roches utilisées pour les calibrations précédentes entraînent une surestimation de ces taux de production, lié à la production de [36]Cl à partir du [35]Cl qui est peu contrainte. Nous avons entrepris une nouvelle calibration à partir de laves datées indépendamment entre 0. 4 et 32 ka situées au Mt Etna (38°N, Italie) et au Payun Matru (36°S, Argentine). Le [36]Cl a été mesuré dans des feldspaths riches en Ca et en K, mais faibles en Cl. A partir d'une approche bayesienne incluant toutes les incertitudes, les taux de production obtenus sont de 42. 2 ± 4. 8 atomes [36]Cl (g Ca) / an pour la spallation du Ca et de 124. 9 ± 8. 1 atomes [36]Cl (g K) / an pour la spallation du K, avec les facteurs d'échelle calculés selon Stone (2000). Quatre autres modèles de facteurs d'échelle sont également proposés avec des résultats très semblables. Ces nouveaux taux de production sont en accord avec les valeurs précédemment obtenues par d'autres auteurs avec des échantillons faibles en Cl. Finalement, les concentrations en [36]Cl, [3]He et [21]Ne ont été mesurées dans des pyroxènes prélevés entre 1000 et 4300 m dans des laves du Kilimandjaro (3°S). Les rapports entre ces nucléides ne montrent pas de dépendance altitudinale, ce qui suggère que les taux de production ne varient pas d'un nucléide à l'autre avec l'altitudePublished cosmogenic [36]Cl SLHL production rates from Ca and K spallation differ by almost 50% (Gosse and Phillips, 2001). The main difficulty in calibrating [36]Cl production rates is to constrain the relative contribution of the various production pathways, which depend on the chemical composition of the rock, particularly on the Cl content. Whole rock [36]Cl exposure ages were compared with [36]Cl exposure ages evaluated in Ca-rich plagioclases in the same independently dated 10 ± 3 ka lava sample taken from Mt. Etna (Sicily, 38° N). Sequential dissolution experiments showed that high Cl concentrations in plagioclase-grains could be significantly reduced after 16% dissolution yielding [36]Cl exposure ages in agreement with the independent age. Stepwise dissolution of whole rock grains, on the other hand, is not as effective in reducing high Cl concentrations as it is for the plagioclase. 330 ppm Cl still remains after 85% dissolution. The [36]Cl exposure ages are systematically about 30% higher than the ages calculated from the plagioclase. We could exclude contamination by atmospheric or magmatic [36]Cl as an explanation for this overestimate. High Cl contents in the calibration samples used for several previous production rate studies are most probably the reason for overestimated spallation production rates from Ca and K. This is due to a poorly constrained nature of [36]Cl production from low-energy neutrons. We used separated minerals, very low in Cl, to calibrate the production rates from Ca and K. [36]Cl was measured in Ca-plagioclases collected from 4 lava flows at Mt. Etna (38° N, Italy, altitudes between 500 and 2000 m), and in K-feldspars from one flow at Payun Matru volcano (36° S, Argentina, altitudes 2300 and 2500 m). The flows were independently dated between 0. 4 and 32 ka. Scaling factors were calculated using five different published scaling models resulting in five calibration data sets. Using a Bayesian statistical model allowed including the major inherent uncertainties. The inferred SLHL spallation production rates from Ca and K are 42. 2 ± 4. 8 atoms [36]Cl (g Ca)-1 a-1 and 124. 9 ± 8. 1 atoms [36]Cl (g K)-1 a-1 scaled with Stone (2000). Using the other scaling methods results in very similar values. These results are in agreement with previous production rate estimations both for Ca and K calibrated with low Cl samples. Moreover, although the exposure durations of our samples are very different and the altitude range is large, the ages recalculated with our production rates are mostly in agreement, within uncertainties, with the independent ages no matter which scaling method is used. However, scaling factors derived from the various scaling methods differ significantly. Cosmic ray flux is sensitive to elevation and its energy spectrum increases considerably with increasing altitude and latitude. To evaluate whether various TCN production rates change differently with altitude and latitude and if nuclide-specific or even target-element-specific scaling factors are required, cosmogenic [36]Cl, [3]He and [21]Ne concentration were determined in pyroxenes over an altitude transect between 1000 and 4300 m at Kilimanjaro volcano (3° S). No altitude-dependency of the nuclide ratios could be observed, suggesting that no nuclide-specific scaling factors be needed for the studied nuclides
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Staali, Leila. "Mecanismes d'activation de canaux ca 2 +, k + et cl et formation de pores transmembranaires par les leucotoxines a deux composes de staphylococcus aureus." Université Louis Pasteur (Strasbourg) (1971-2008), 1999. http://www.theses.fr/1999STR13086.
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Staphylococcus aureus secrete une famille de leucotoxines membranolytiques associees a differentes pathologies infectieuses. Parmi celles-ci, la leucocidine de panton et valentine (lpv) et la -hemolysine sont composees de proteines de classe s (hlga, hlgc, luks-pv) et de proteines de classe f (hlgb, lukf-pv) qui ne sont toxiques qu'en synergie sur la membrane des cellules-cibles. Le mode d'action physiologique des differentes associations : hlga/hlgb, hlgc/hlgb, luks-pv/lukf-pv a ete etudie sur des polynucleaires neutrophiles humains, a l'aide de techniques de spectrofluorimetrie et de sondes moleculaires fluorescentes. Dans un premier temps, les composes de classe s se fixent sur des recepteurs membranaires. Dans un deuxieme temps, la fixation secondaire des composes de classe f entraine l'activation de differentes voies de signalisation intracellulaire pour activer differents effecteurs membranaires. Ainsi, differents types de canaux calciques pre-existants permeables aux cations divalents (ca 2 +, zn 2 +, mn 2 +) sont actives via des proteines g trimeriques : i) des canaux calciques ca 2 + - independants, ii) des canaux crac apres mobilisation des reserves intracellulaires de ca 2 + de type ip 3-icr et cicr et iii) des canaux calciques pkc-dependant selon le couple leucotoxique teste. Les leucotoxines activent egalement, des canaux k + ca 2 +-dependant et des canaux cl dont les canaux cl ca 2 +-dependant. L'ensemble de ces evenements active diverses fonctions cellulaires des pn impliques dans la defense anti-bacterienne. Apres insertion et polymerisation des deux composes (s et f) dans la membrane, se forment des pores impermeables aux cations divalents (ca 2 +, zn 2 +, mn 2 +) et au cl. Par contre, ils presentent une forte specificite aux cations monovalents (na +, k +) conduisant ainsi, a une necrose cellulaire.
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Pachot, Stéphanie. "Etudes structurales des composés à échelles de spins du type A14 Cu24 O[41+(delta)] (A = Sr, Ca, Ba, Nd, Y, Na, K)." Université Joseph Fourier (Grenoble), 1999. http://www.theses.fr/1999GRE10133.
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Volpato, Karine Cunha. "Envolvimento de canais de K+ e vias dependentes de Ca++ no efeito estimulatório do T3 no transporte de aminoácidos em testículos de ratos imaturos." Florianópolis, SC, 2002. http://repositorio.ufsc.br/xmlui/handle/123456789/84222.
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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Farmácia.Made available in DSpace on 2012-10-20T07:24:01Z (GMT). No. of bitstreams: 0Bitstream added on 2014-09-26T02:05:23Z : No. of bitstreams: 1 186336.pdf: 9976751 bytes, checksum: 23f7b81ec4c22498bdd30e552cb9d3b0 (MD5)
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Ilali, Jaffar. "Contribution à l'étude des systèmes M²+F-M+F-LnF, avec M+ = Pb, Ba, Sr et Ca, M+ = K, Na et Rb Ln³Yn La." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb376144866.
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Moretto, Philippe. "Dosage comparatif du silicium et des éléments légers (P, S, Cl, K, Ca) par les techniques nucléaires, en macro et microfaisceau dans des parois artérielles." Bordeaux 1, 1987. http://www.theses.fr/1987BOR10569.
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Hemon, Annie. "Cristallogenèse et étude structurale dans les systèmes fluorés ternaires AF-MF2-M'F3. (A=Na,K;M=Ca,Sr,Ba,Cd;M'=Al et éléments 3d)." Le Mans, 1991. http://www.theses.fr/1991LEMA1001.
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La croissance en flux de chlorures, mais aussi la croissance par voie hydrothermale et la synthese dans l'etat solide ont permis de mettre en evidence dans les systemes af-mf#2-mf#3 (a=na, k; m=ca, sr, ba, cd; m=al et elements 3d) plusieurs familles de composes presentant des types structuraux nouveaux. Quatre types structuraux ont ete mis en evidence avec la composition nammf#6: 1) -nacaalf#6 de type na#2sif#6 avec un ordre cationique inverse par rapport aux phases namnmf#6; 2) nasrfef#6 avec un reseau de type hexagonal compact de fluors; 3) nasralf#6 et nasrcrf#6 (b. T. ) avec des octaedres isoles mf#6; 4) nacdalf#6 avec des chaines trans d'octaedres et un fluor independant. Une autre phase de formulation nasr#2crf#8 possede egalement des fluors independants. Deux phases amm#2f#9 ont ete etudies: nasrti#2f#9 et kcaal#2f#9. Elles possedent toutes les deux des couches de type bronze hexagonal (nati#2f#9#n, caal#2f#9#n respectivement). Une phase de formulation proche na#4ca#4al#7f#3#3 presente un reseau tridimensionnel d'octaedres d'aluminium. Des phases de formulation originale ont ete mises en evidence: 1) na#3sr#4al#5f#2#6 et na#3sr#4cr#5f#2#6: structures a base de pentameres d'octaedres m#5f#2#6 en forme de plan ou de tetraedre; 2) na#2sr#7al#6f#3#4, homologue synthetique du mineral jarlite. Un fluorochlorure sr#1#0al#2f#2#5cl a egalement ete synthetise; il possede un reseau tridimensionnel de polyedres de strontium, le chlore est entoure octaedriquement par des strontiums. Les correlations structurales de ces nouveaux composes avec les types structuraux connus sont presentes ainsi que la caracterisation magnetique des especes engageant des elements paramagnetiques
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Carr, Hilda P. "The accumulation of aluminium and it's effect on the uptake and distribution of Ca, Mg, K, Mn, Fe, Cu and Zn in Camellia sinesis (L.)." HKBU Institutional Repository, 2001. http://repository.hkbu.edu.hk/etd_ra/287.
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Moretto, Philippe. "Dosage comparatif du silicium et des éléments légers (P, S, Cl, K, Ca) par les techniques nucléaires, en macro et micro-faisceau, dans des parois artérielles." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37608166h.
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Jin, Min. "Activation of Ca2+-activated K+ Channels and Cell Migration by Hepatocyte Growth Factor/Scatter Factor in Madin-Darby Canine Kidney Cells." [Johnson City, Tenn. : East Tennessee State University], 2002. http://etd-submit.etsu.edu/etd/theses/available/etd-0903102-100659/unrestricted/JinM091302a.pdf.
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