Relevant bibliographies by topics / K+-channels blockers

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers
  5. Reports

Academic literature on the topic 'K+-channels blockers'

Author: Grafiati
Published: 7 June 2025
Last updated: 2 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'K+-channels blockers.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "K+-channels blockers"

1

Yaghi, Asma, Sanjay Mehta, and David G. McCormack. "Delayed rectifier potassium channels contribute to the depressed pulmonary artery contractility in pneumonia." Journal of Applied Physiology 93, no. 3 (2002): 957–65. http://dx.doi.org/10.1152/japplphysiol.01146.2001.

Full text
Abstract:
We investigated the role of K+ channels in the attenuated pulmonary artery (PA) contractility characteristic of acute Pseudomonaspneumonia. Contractility of PA rings from the lungs of control or pneumonia rats was assessed in vitro by obtaining cumulative concentration-response curves to the contractile agonists KCl, phenylephrine, or PGF2α on PA rings before and after treatment with K+ channel blockers. In rings from pneumonia rats, paxilline (10 μM), tetraethylammonium (2 mM) (blockers of large-conductance Ca2+-activated K+ channels), and glybenclamide (ATP-sensitive K+ channel blocker, 80 μ
APA, Harvard, Vancouver, ISO, and other styles
2

Blaustein, Robert O. "Kinetics of Tethering Quaternary Ammonium Compounds to K+ Channels." Journal of General Physiology 120, no. 2 (2002): 203–16. http://dx.doi.org/10.1085/jgp.20028613.

Full text
Abstract:
Polymeric maleimido–quaternary ammonium (QA) compounds have been shown to function as molecular tape measures when covalently tethered to external cysteine residues of a Shaker K+ channel (Blaustein R.O., P.A. Cole, C. Williams, and C. Miller. 2000. Nat. Struct. Biol. 7:309–311). For sufficiently long compounds, the cysteine–maleimide tethering reaction creates a high concentration, at the channel's pore, of a TEA-like moiety that irreversibly blocks current. This paper investigates a striking feature of the maleimide–cysteine tethering kinetics. Strong blockers—those that induce substantial l
APA, Harvard, Vancouver, ISO, and other styles
3

Wang, X., T. Inukai, M. A. Greer, and S. E. Greer. "Rat Prl and TSH secretion are regulated differently by K(+)-channel blockers." American Journal of Physiology-Endocrinology and Metabolism 266, no. 1 (1994): E39—E43. http://dx.doi.org/10.1152/ajpendo.1994.266.1.e39.

Full text
Abstract:
All four different K(+)-channel blockers [tetraethylammonium (TEA), a nonselective K(+)-channel blocker; tolbutamide, an ATP-sensitive K(+)-channel blocker; quinine and 4-aminopyridine, both primarily voltage-dependent K(+)-channel blockers] stimulated prolactin (Prl) secretion by acutely dispersed anterior pituitary cells but had no effect on thyroid-stimulating hormone (TSH) secretion. TEA stimulated Prl secretion in a dose-dependent manner between 1 microM and 20 mM, but even as high as 20 mM, TEA did not induce TSH secretion. Valinomycin (2 microM), a K+ ionophore, inhibited both basal and
APA, Harvard, Vancouver, ISO, and other styles
4

Illek, B., H. Fischer, K. M. Kreusel, U. Hegel, and W. Clauss. "Volume-sensitive basolateral K+ channels in HT-29/B6 cells: block by lidocaine, quinidine, NPPB, and Ba2+." American Journal of Physiology-Cell Physiology 263, no. 3 (1992): C674—C683. http://dx.doi.org/10.1152/ajpcell.1992.263.3.c674.

Full text
Abstract:
Volume-sensitive basolateral K+ channels were studied in apically amphotericin B-permeabilized HT-29/B6 monolayers in Ussing chambers with current fluctuation analysis. The basolateral K+ conductance and Lorentzian K+ channel noise were osmotically activated in presence of Cl- concentrations greater than or equal to 74 mM. Under isotonic conditions with 148 mM Cl-, a large transepithelial K+ current of 500 +/- 16.8 microA/cm2 and a spontaneous Lorentzian K+ channel noise with a corner frequency of 29.8 +/- 1.6 Hz (n = 31) were observed. Increasing extracellular osmolalities by addition of sucr
APA, Harvard, Vancouver, ISO, and other styles
5

Holmgren, Miguel, Paula L. Smith, and Gary Yellen. "Trapping of Organic Blockers by Closing of Voltage-dependent K+ Channels." Journal of General Physiology 109, no. 5 (1997): 527–35. http://dx.doi.org/10.1085/jgp.109.5.527.

Full text
Abstract:
Small organic molecules, like quaternary ammonium compounds, have long been used to probe both the permeation and gating of voltage-dependent K+ channels. For most K+ channels, intracellularly applied quaternary ammonium (QA) compounds such as tetraethylammonium (TEA) and decyltriethylammonium (C10) behave primarily as open channel blockers: they can enter the channel only when it is open, and they must dissociate before the channel can close. In some cases, it is possible to force the channel to close with a QA blocker still bound, with the result that the blocker is “trapped.” Armstrong (J.
APA, Harvard, Vancouver, ISO, and other styles
6

Hill, Ceredwyn Elizabeth, and Jody Elisabeth Jacques. "Cholestatic effects of the K+ channel blockers Ba2+ and TEA occur through different pathways in the rat liver." American Journal of Physiology-Gastrointestinal and Liver Physiology 276, no. 1 (1999): G43—G48. http://dx.doi.org/10.1152/ajpgi.1999.276.1.g43.

Full text
Abstract:
The role of K+ channels in bile acid-independent bile flow (BAIF) was studied in the isolated and bile duct-cannulated perfused rat liver by changing the driving force on K+and by using a variety of K+channel blockers. Bile flow rate, effluent perfusate K+ content, and portal pressure were measured. Increase in perfusate K+ from 5.9 to 80 mM caused inhibition of bile flow that could be fitted to a Boltzmann distribution, indicating partial dependence of bile formation on the K+ equilibrium potential and hence K+ channel activity. To investigate this further, the effects of compounds establishe
APA, Harvard, Vancouver, ISO, and other styles
7

Choi, Chang-Rok, Eun-Jin Kim, Tae Hyun Choi, Jaehee Han, and Dawon Kang. "Enhancing Human Cutaneous Wound Healing through Targeted Suppression of Large Conductance Ca2+-Activated K+ Channels." International Journal of Molecular Sciences 25, no. 2 (2024): 803. http://dx.doi.org/10.3390/ijms25020803.

Full text
Abstract:
The modulation of K+ channels plays a crucial role in cell migration and proliferation, but the effect of K+ channels on human cutaneous wound healing (CWH) remains underexplored. This study aimed to determine the necessity of modulating K+ channel activity and expression for human CWH. The use of 25 mM KCl as a K+ channel blocker markedly improved wound healing in vitro (in keratinocytes and fibroblasts) and in vivo (in rat and porcine models). K+ channel blockers, such as quinine and tetraethylammonium, aided in vitro wound healing, while Ba2+ was the exception and did not show similar effec
APA, Harvard, Vancouver, ISO, and other styles
8

Artym, Vira V., та Howard R. Petty. "Molecular Proximity of Kv1.3 Voltage-gated Potassium Channels and β1-Integrins on the Plasma Membrane of Melanoma Cells". Journal of General Physiology 120, № 1 (2002): 29–37. http://dx.doi.org/10.1085/jgp.20028607.

Full text
Abstract:
Tumor cell membranes have multiple components that participate in the process of metastasis. The present study investigates the physical association of β1-integrins and Kv1.3 voltage-gated potassium channels in melanoma cell membranes using resonance energy transfer (RET) techniques. RET between donor-labeled anti–β1-integrin and acceptor-labeled anti-Kv1.3 channels was detected on LOX cells adherent to glass and fibronectin-coated coverslips. However, RET was not observed on LOX cells in suspension, indicating that molecular proximity of these membrane molecules is adherence-related. Several
APA, Harvard, Vancouver, ISO, and other styles
9

Hur, Chang-Gi, Eun-Jin Kim, Seong-Keun Cho, et al. "K+ efflux through two-pore domain K+ channels is required for mouse embryonic development." REPRODUCTION 143, no. 5 (2012): 625–36. http://dx.doi.org/10.1530/rep-11-0225.

Full text
Abstract:
Numerous studies have suggested that K+ channels regulate a wide range of physiological processes in mammalian cells. However, little is known about the specific function of K+ channels in germ cells. In this study, mouse zygotes were cultured in a medium containing K+ channel blockers to identify the functional role of K+ channels in mouse embryonic development. Voltage-dependent K+ channel blockers, such as tetraethylammonium and BaCl2, had no effect on embryonic development to the blastocyst stage, whereas K2P channel blockers, such as quinine, selective serotonin reuptake inhibitors (fluox
APA, Harvard, Vancouver, ISO, and other styles
10

Fujii, Naoto, Jeffrey C. Louie, Brendan D. McNeely, Tatsuro Amano, Takeshi Nishiyasu, and Glen P. Kenny. "Mechanisms of nicotine-induced cutaneous vasodilation and sweating in young adults: roles for KCa, KATP, and KV channels, nitric oxide, and prostanoids." Applied Physiology, Nutrition, and Metabolism 42, no. 5 (2017): 470–78. http://dx.doi.org/10.1139/apnm-2016-0615.

Full text
Abstract:
We evaluated the influence of K+ channels (i.e., Ca2+-activated K+ (KCa), ATP-sensitive K+ (KATP), and voltage-gated K+ (KV) channels) and key enzymes (nitric oxide synthase (NOS) and cyclooxygenase (COX)) on nicotine-induced cutaneous vasodilation and sweating. Using intradermal microdialysis, we evaluated forearm cutaneous vascular conductance (CVC) and sweat rate in 2 separate protocols. In protocol 1 (n = 10), 4 separate sites were infused with (i) lactated Ringer (Control), (ii) 50 mmol·L−1 tetraethylammonium (KCa channel blocker), (iii) 5 mmol·L−1 glybenclamide (KATP channel blocker), an
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "K+-channels blockers"

1

Spigelman, Igor. "Sensory transmission in peripheral neurons : effects of K+ channel blockers and autacoids." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/29437.

Full text
Abstract:
Sensory transmission was studied in trigeminal root ganglia (TRG) of guinea pigs, using intracellular recording techniques. One approach was to examine in detail the effects of applications of different K⁺-channel blockers on the membrane voltage responses and outward currents of TRG neurons, in order to better understand the fundamental processes that affect their excitabilities and repetitive spike discharge. The second approach was to examine several endogenous substances for their effects on the excitabilities of TRG neurons. In addition, a strategy was developed for electrophysiological
APA, Harvard, Vancouver, ISO, and other styles
2

Ninomiya, Tomonori. "Verapamil, a Ca[2+] entry blocker, targets the pore-forming subunit of cardiac type K[ATP] channel (Kir6.2)." Kyoto University, 2004. http://hdl.handle.net/2433/147501.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Kuttruff, Christian A. [Verfasser]. "Total Synthesis of Variecolortides A–C – Studies towards the Total Synthesis of Naphthomycin K and Divergolides C and D – Synthesis of Photochromic Open Channel Blockers / Christian A. Kuttruff." München : Verlag Dr. Hut, 2012. http://d-nb.info/1028783116/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Assis, Valeria Lopes de. "Ensaios Farmacológicos Pré-clínicos no Trato Digestório com um Produto Fitoterápico." Universidade Federal da Paraí­ba, 2012. http://tede.biblioteca.ufpb.br:8080/handle/tede/6777.

Full text
Abstract:
Made available in DSpace on 2015-05-14T12:59:49Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 1843957 bytes, checksum: 23eff6067396c6f267138994bec5be02 (MD5) Previous issue date: 2012-02-13<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>The studed Herbal Product is indicated for treatment of intestinal colic and constipation, though there are no scientific data, that prove its efficacy. Thus, this study aimed in preclinical pharmacologic trials to evaluate its laxative and spasmolytic action and elucidate its possible pathway. For this, pharmacological tests wer
APA, Harvard, Vancouver, ISO, and other styles
5

Kuttruff, Christian Andreas [Verfasser], and Dirk [Akademischer Betreuer] Trauner. "Total synthesis of variecolortides A–C : towards the total synthesis of naphthomycin K and divergolides C and D; synthesis of photochromic open-channel blockers / Christian Andreas Kuttruff. Betreuer: Dirk Trauner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/102621128X/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Wang, Iren, and 王怡人. "Studies of the Solution Structure of a K+ Channel Blocker from." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/21958020178480990614.

Full text
Abstract:
碩士<br>國立臺灣大學<br>生化科學研究所<br>90<br>Tc1 is a new K+ channel-blocking peptide identified from the scorpion venom of Tityus cambridgei and composed of 23 amino acid residues with three disulfide bridges. It is the shortest known toxin from scorpion venom that recognizes the Shaker B K+ channels and the voltage-gated K+ channels in brain. Synthetic Tc1 was produced by solid-phase synthesis and purified by reversed-phase HPLC. The pairings of three disulfide bridges in the synthetic Tc1 were identified as Cys2-Cys15、Cys5-Cys20及Cys9-Cys22 by NMR experiments. The NMR solution structures of Tc1 were det
APA, Harvard, Vancouver, ISO, and other styles
7

趙國芳. "Effects of K-channel blockers on the neuromuscular blocking action of -bungar-otoxin." Thesis, 1988. http://ndltd.ncl.edu.tw/handle/05934929810949946823.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Huang, I.-Che, and 黃一. "Structural studies of the K+ Channel Blocker Tc32 from the Scorpion Tityus cambridgei." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/77224032821627684935.

Full text
Abstract:
碩士<br>國立臺灣大學<br>生化科學研究所<br>92<br>Abstracts: Ion channels are involved in diverse biological processes and play essential roles in the physiology of all cells. An increasing number of human and animal diseases have been identified to relate with the defective function of ion channels. Scorpion venoms contain various polypeptides (channel blockers) that particularly affect the permeability of ion channels in cell membranes. Thus, understanding the structural basis of the specificity of scorpion toxins for these receptors could lead to the design of new ligands with controlled activity
APA, Harvard, Vancouver, ISO, and other styles
9

Huang, I.-Che, and 黃一喆. "Structural studies of the K+ Channel Blocker Tc32,from the Scorpion Tityus cambridgei." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/62848192842695498510.

Full text
Abstract:
碩士<br>國立臺灣大學<br>生化科學研究所<br>92<br>Abstracts: Ion channels are involved in diverse biological processes and play essential roles in the physiology of all cells. An increasing number of human and animal diseases have been identified to relate with the defective function of ion channels. Scorpion venoms contain various polypeptides (channel blockers) that particularly affect the permeability of ion channels in cell membranes. Thus, understanding the structural basis of the specificity of scorpion toxins for these receptors could lead to the design of new ligands with controlled activity and potenc
APA, Harvard, Vancouver, ISO, and other styles
10

Chang, Sho-Fine. "Synthesis and structural analysis of mutant K+ channel blocker Tc32, from the Scorpion Tityus cambridgei." 2006. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2007200613114100.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "K+-channels blockers"

1

Lambert, Paul F., Hisaya Kuroda, Naoyoshi Chino, Takushi X. Watanabe, Terutoshi Kimura, and Shumpei Sakakibara. "Solution-phase synthesis of the K+ channel blocker, charybdotoxin." In Peptides 1990. Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3034-9_45.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Van Rietschoten, J., R. Romi, M. Crest, et al. "Structure activity relationship studies on kaliotoxin, a peptidic K+ channel blocker." In Peptides. Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-0683-2_175.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

M.C. Bastos, Fatima, Carlos M. Matias, Ines O. Lopes, et al. "FAD-Linked Autofluorescence and Chemically-Evoked Zinc Changes at Hippocampal Mossy Fiber-CA3 Synapses." In Hippocampus - Cytoarchitecture and Diseases. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.100898.

Full text
Abstract:
Glutamatergic vesicles in hippocampal mossy fiber presynaptic boutons release zinc, which plays a modulatory role in synaptic activity and LTP. In this work, a fluorescence microscopy technique and the fluorescent probe for cytosolic zinc, Newport Green (NG), were applied, in a combined study of autofluorescence and zinc changes at the hippocampal mossy fiber-CA3 synaptic system. In particular, the dynamics of flavoprotein (FAD) autofluorescence signals, was compared to that of postsynaptic zinc signals, elicited both by high K+ (20 mM) and by tetraethylammonium (TEA, 25 mM). The real zinc sig
APA, Harvard, Vancouver, ISO, and other styles
4

Wang, Di, Xin Peng, and Yahui Xue. "Nanofluidic Thermoelectric Materials." In Advanced Thermoelectric Materials - Theory, Development, and Applications [Working Title]. IntechOpen, 2025. https://doi.org/10.5772/intechopen.1009888.

Full text
Abstract:
Thermoelectric transducers have attracted significant attention owing to their immense potential in energy harvesting and biomimetic applications, such as waste heat recovery and the design of advanced thermal sensors. Although traditional thermoelectric semiconductors exhibit excellent thermoelectric performance at room temperature, their toxicity and rarity limit their practical applications. In recent years, with the emergence of advanced materials such as graphene, MXenes, and COFs, inspirations have been provided by biological thermosensitive ion channels to construct nanofluidic thermoel
APA, Harvard, Vancouver, ISO, and other styles
5

Garcia, M. L. "Charybdotoxin and iberiotoxin (Leiurus quinquestriatus var. hebraeus and Buthus tamulus)." In Guidebook to Protein Toxins and Their Use in Cell Biology. Oxford University PressOxford, 1997. http://dx.doi.org/10.1093/oso/9780198599555.003.0054.

Full text
Abstract:
Abstract Charybdotoxin (ChTX) and iberiotoxin (lbTX) are 37 amino acid peptides containing six Cys residues that form three disulfide bridges (Gimenez-Gallego et al. 1988; Galvez et al. 1990). Both peptides have their N-terminal residue blocked in the form of pyroglutamic acid and share 68 per cent homology in their amino acid sequences (Fig. 1). The three-dimensional structure of these peptides has been determined in solution by NMR techniques (Bontems et al. 1991; Johnson and Sugg 1992). The backbone of both peptides is identical. The surfaces of ChTX and lbTX are formed by three small antip
APA, Harvard, Vancouver, ISO, and other styles
6

Jonnada, Kiran Sai Kumar. "Cardiovascular Therapeutics." In Evidence-Based Pharmacotherapy in Clinical Practice. THINKPLUS PHARMA PUBLICATIONS, 2025. https://doi.org/10.69613/t97t6241.

Full text
Abstract:
Current pharmacological management of cardiovascular disorders encompasses multiple drug classes targeting specific pathophysiological mechanisms. Hypertension treatment follows stepped-care algorithms incorporating angiotensin-system modulators, calcium channel blockers, and diuretics based on patient characteristics and comorbidities. Heart failure management utilizes mortality-reducing agents including beta-blockers, ACE inhibitors, and mineralocorticoid antagonists, with careful monitoring of hemodynamic parameters and organ function. Coronary artery disease interventions focus on anti-isc
APA, Harvard, Vancouver, ISO, and other styles
7

Hugues, M., and M. Lazdunski. "Scyllatoxin (Leiurus quinquestriatus hebraeus)." In Guidebook to Protein Toxins and Their Use in Cell Biology. Oxford University PressOxford, 1997. http://dx.doi.org/10.1093/oso/9780198599555.003.0051.

Full text
Abstract:
Abstract Scyllatoxin (sequence accession number to the Swiss Prot databank: P16341 SCKL LEIQH) is a peptidic neurotoxin which specifically blocks low conductance Ca2+-dependent K+ channels (sK) (Chicchi et al. 1988; Auguste et al. 1990). These channels have previously been demonstrated to be associated with apamin receptors, another peptidic toxin with 18 amino acids purified from bee venom (Hugues et al. 1982a,b). Scyllatoxin is composed of 31 amino acids and is reticulated by three disulphide bridges. Structure-function studies have shown that Arg6, Arg13, and His31 are crucial for toxin/rec
APA, Harvard, Vancouver, ISO, and other styles
8

Taber, Douglass. "Alkaloid Synthesis: Paliurine F, Lepadiformine, and 7-Deoxypancratistatin." In Organic Synthesis. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199764549.003.0057.

Full text
Abstract:
The sedative alkaloid paliurine F 7 is a pentapeptide bridged by an arene. Gwilherm Evano of the Université de Versailles took advantage of this in his synthesis (Angew. Chem. Int. Ed. 2007, 46, 572) of 7, although it was necessary to prepare, from serine, one of the amino acid derivatives, the protected 3-hydroxyprolinol 2. The key step in the synthesis was the Cu-catalyzed intramolecular coupling of 5 to give the macrolactam 6. Deprotection and acylation then gave paliurine F 7. Lepadiformine 14, isolated from the tunicate Clavelina lepadiformis, shows moderate cytotoxicity, and is also a K+
APA, Harvard, Vancouver, ISO, and other styles
9

Forster, Craig B., Stephen H. Snelgrove, Siang Joo Lim, et al. "3-D Fluid-Flow Simulation in a Clastic Reservoir Analog." In Regional to Wellbore Analog for Fluvial-Deltaic Reservoir Modeling. American Association of Petroleum Geologists, 2004. https://doi.org/10.1306/st50983c16.

Full text
Abstract:
Abstract An integrated data set containing detailed three-dimensional ground-penetrating radar surveys, outcrop mapping, and both in situand lab-based petrophysical measurements provides an unusually detailed foundation for simulating fluid flow through the three-dimensional permeability structure of a channel sandstone reservoir analog within a study volume 40 m x 20 m (130 ft x 60 ft) (in plan) and 15 m (45 ft) deep. Permeability (k)data (more than 1100 data points ranging from 0.5-300 md) are obtained from probe permeameter measurements made on core plugs collected from five vertical cliff-
APA, Harvard, Vancouver, ISO, and other styles
10

Xie, Yuling, Philip L. Verplanck, Zengqian Hou, and Richen Zhong. "Chapter 12 Rare Earth Element Deposits in China: A Review and New Understandings." In Mineral Deposits of China. Society of Economic Geologists, 2019. http://dx.doi.org/10.5382/sp.22.12.

Full text
Abstract:
Abstract China has been the world’s leading rare earth element (REE) and yttrium producer for more than 20 years and hosts a variety of deposit types. Carbonatite-related REE deposits are the most significant REE deposit type, with REY (REE and yttrium)-bearing clay deposits, or ion adsorption-type deposits, being the primary source of the world’s heavy REEs. Other REY resources in China include those hosted in placers, alkaline granites, pegmatites, and hydrothermal veins, as well as in additional deposit types in which REEs may be recovered as by-product commodities. Carbonatite-related REE
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "K+-channels blockers"

1

Fundora Ortiz, Brenda de la Caridad. "Maxi-K channels: structure, characteristics, biological process and principal blockers and activators. A general overview." In MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed. MDPI, 2021. http://dx.doi.org/10.3390/mol2net-07-11822.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Johnson, G. J., P. C. Dunlop, M. J. Rabiet, L. A. Leis, and AH L. From. "THE DIHYDROPYRIDINE CALCIUM CHANNEL AGONIST, BAY K 8644, AND THE ANTAGONIST, NIFEDIPINE, INHIBIT U46619-INDUCED HUMAN PLATELET ACTIVATION BY COMPETITIVE BINDING TO THE THROMBOXANE A22/PGH2 RECEPTOR." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643756.

Full text
Abstract:
The dihydropyridine (DP) Ca2+ channel antagonist, nifedipine (NF), inhibits platelet aggregation .in vitro and ex vivo by an undefined mechanism. Inhibition of Ca2+ influx via Ca2+ channels is a postulated mechanism, but voltage-dependent Ca2+ channels have not been demonstrated in platelets. We previously observed that NF blocked thromboxane A2 (TXA2)-induced platelet aggregation and secretion. In order to further evaluate the mechanism of DP inhibition of platelet activation, we studied the effects of NF and BAY K 8644, (BAY), a DP with opposite (agonist) effects on muscle cells, on human pl
APA, Harvard, Vancouver, ISO, and other styles
3

Sarid, Dror, Wayne M. Gibbons, and Mial E. Warren. "Optical Waveguides in Multiple Quantum Well Structures." In Optical Bistability. Optica Publishing Group, 1985. http://dx.doi.org/10.1364/obi.1985.wa5.

Full text
Abstract:
Nonlinear channel waveguides can serve as building blocks for all-optical processing devices such as directional couplers, Mach-Zehnder interferometers, and ring channels. An attractive nonlinear medium for such devices is an excitonic system such as a MQW structure, since the nonlinearity is large and the operating wavelength is compatible with solid-state lasers. In contrast to electronic or bandfilling nonlinearities, the calculation of the parameters of an excitonic system is complicated by the fact that the absorption as well as the nonlinear refractive index are a function of the local i
APA, Harvard, Vancouver, ISO, and other styles
4

Luo, Jianxia, Cunliang Liu, and Huiren Zhu. "Numerical Investigation of Film Cooling Performance With Different Internal Flow Structures." In ASME Turbo Expo 2014: Turbine Technical Conference and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/gt2014-25314.

Full text
Abstract:
Four coolant channel configurations, including supply plenum without crossflow, smooth channel with crossflow and ribbed channels with crossflow ( 135° and 45° angled ribs), are simulated to find out the effect of internal flow structures on the external film cooling performance. Reynolds Averaged Navier Stokes (RANS) simulations with realizable k-ε turbulence model and enhanced wall treatment are performed using a commercial code Fluent. Blowing ratios cover a range from 0.5 to 2.0. For the three cases with crossflow, a constant Reynolds number, ReDh, is fixed as 100000. Particular attention
APA, Harvard, Vancouver, ISO, and other styles
5

Qu, Huancheng, Di Zhang, Yonghui Xie, Shouhong Cao, and Qilin Wu. "Numerical Simulation of Unsteady Flow Phenomena and Exciting Force in Control Stage of Steam Turbine Under Multiple Working Conditions." In ASME 2011 Power Conference collocated with JSME ICOPE 2011. ASMEDC, 2011. http://dx.doi.org/10.1115/power2011-55261.

Full text
Abstract:
Partial admission is applied wildly to regulate the power in turbomachinery. The prominent unsteady characteristic has a great effect on the aerodynamic performance and unit safety. The RNG k-ε turbulence model, dual time step method, sliding interface model and structural hexahedron mesh were adopted and the 3-D unsteady viscous model for the full annulus of the control stage of 300MW steam turbine with admission room and reinforced rib was constructed. The flow phenomena and exciting force were investigated detailed in multiple working conditions. The time-averaged unsteady wheel efficiency
APA, Harvard, Vancouver, ISO, and other styles
6

Daskiran, Cosan, Jacob Riglin, and Alparslan Oztekin. "Numerical Analysis of Blockage Ratio Effect on a Portable Hydrokinetic Turbine." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-65828.

Full text
Abstract:
Three-dimensional steady state Computational Fluid Dynamics (CFD) analyses were performed for a pre-designed micro-hydrokinetic turbine to investigate the blockage ratio effect on turbine performance. Simulations were conducted using a physical turbine rotor geometry rather than low fidelity, simplified actuator disk or actuator lines. The two-equation k-ω Shear Stress Transport (SST) turbulence model was employed to predict turbulence in the flow field. The turbine performance at the best efficiency point was studied for blockage ratios of 0.49, 0.70 and 0.98 for three different free stream v
APA, Harvard, Vancouver, ISO, and other styles
7

Hara, Kazuo, Masato Furukawa, and Naoki Akihiro. "Experimental and Numerical Analysis of High Heat Transfer Phenomenon in Minichannel Gaseous Cooling." In ASME 4th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2006. http://dx.doi.org/10.1115/icnmm2006-96213.

Full text
Abstract:
The authors have reported that minichannel flow system had high heat transfer coefficient, the reason of which was investigated experimentally and numerically for single and array minichannels combined with impingement flow system. The diameter D of the channel was 1.27 mm and length to diameter ratio L/D was 5. The minichannel array was so called shower head which was constructed by 19 minichannels located at the apex of equilateral triangle, the side length S of which was 4 mm. Single stage block was used to investigate the heat transfer without impinging flow system. Two stage blocks were u
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "K+-channels blockers"

1

Yibchok-anun, Sirinthorn, Wijit Banlunara, and Sirichai Adisakwattana. Antidiabetic effects, mechanisms of of p-methoxy-trans-cinnamic acid. Faculty of Veterinary Science, Chulalongkorn University, 2008. https://doi.org/10.58837/chula.res.2008.81.

Full text
Abstract:
p-Methoxycinnamic acid (p-MCA) is a cinnamic acid derivative that shows various pharmacologic actions such as neuroprotective and hepatoprotective activities. To examine the insulinotropic activity of p-MCA, the perfused rat pancreas and a pancreatic β-cell line, INS-1 were used in the studies. P-MCA increased insulin secretion from the perfused rat pancreas and INS-1 cells in a concentration-dependent manner. In addition, p-MCA increased intracellular Ca²⁺ concentration ([Ca²⁺]i) in INS-1 cells. The p-MCA-induced insulin secretion and rise in [Ca²⁺]i were markedly inhibited in the absence of
APA, Harvard, Vancouver, ISO, and other styles
2

O. C. Bernardo, Felipe, Sebastião V. Canevarolo, and José A. C. G. Covas. Evaluation of temperature impact during extrusion on the mixing levels of PS/PA6 by optical monitoring. Universidad de los Andes, 2024. https://doi.org/10.51573/andes.pps39.gs.ex.2.

Full text
Abstract:
This work uses on-line monitoring of turbidity to ascertain the temperature impact on the mixing performance of kneading blocks with different geometries. For this purpose, one of the barrel segments of the extruder was modified to incorporate four sampling devices and a slit die containing optical windows. The experiments consisted in reaching steady extrusion and then adding a small amount of tracer. Upon opening each sampling device, material was laterally detoured from the local screw channel and its turbidity were measured by the optical detector. Residence time distribution (RTD) curves
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'K+-channels blockers' for particular source types:
Journal articles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography