Academic literature on the topic 'K-Opioid receptor'

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Journal articles on the topic "K-Opioid receptor"

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Ruzicka, Bianca B., та Khem Jhamandas. "The K+-evoked release of [3H]acetylcholine from slices of rat globus pallidus: modulation by δ-opioid receptors". Canadian Journal of Physiology and Pharmacology 69, № 3 (1991): 414–18. http://dx.doi.org/10.1139/y91-063.

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Previous investigations have shown that the activation of δ-opioid receptors depresses the release of acetylcholine (ACh) in the rat caudate putamen. This finding raised the possibility that the release of ACh is similarly modulated in the globus pallidus, a region containing a distinct population of cholinergic neurons and enriched in enkephalinergic nerve terminals. In the present study the pallidal release of ACh was characterized and the effects of δ-opioid receptor activation on this release were examined. The results show that this release is stimulated by high K+ in a concentration- and
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Ruzicka, Bianca B., та Khem Jhamandas. "Depression of potassium-evoked striatal acetylcholine release by δ-receptor activation: inhibition by cholinoactive agents". Canadian Journal of Physiology and Pharmacology 66, № 12 (1988): 1487–92. http://dx.doi.org/10.1139/y88-243.

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To examine the role of δ-opioid receptors in the modulation of striatal acetylcholine (ACh) release, the action of D-Pen2,L-Pen5-enkephalin, a selective δ-opioid receptor agonist, was tested on [3H]ACh release from slices of the rat caudate–putamen. Slices, incubated with [3H]choline, were superfused with a physiological buffer and stimulated twice by exposure to a high potassium (K+) concentration. In the absence of a cholinesterase inhibitor, 1 μM D-Pen2,L-Pen5-enkephalin produced a 46 and 35% decrease in the release of [3H]ACh evoked by 15 and 25 mM K+, respectively. The depressant action o
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Lauro, Figueroa-Valverde, Rosas-Nexticapa Marcela, Mateu-Armand Virginia та ін. "Preparation of two Cyclobutadiene-steroid derivatives Theoretical Analysis of its Interaction with the μ, d, and k Opiod-receptors". Oriental Journal of Chemistry 34, № 6 (2018): 2689–702. http://dx.doi.org/10.13005/ojc/340601.

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The objective of this investigation was to develop two cyclobutadiene-steroid derivatives (compounds 6 or 7) to evaluate its theoretical interaction on µ, d, and k opioid-receptors. The synthesis of 6 or 7 was carried out using a series of reactions which involves. 1) addition/cyclization: 2) imination, 3) etherification and 4) oxy-functionalization. Chemical structure of all compounds was confirmed using elemental analysis and NMR spectra. In addition, a theoretical analysis on the interaction of compounds 6 or 7 with µ, d, and k opioid-receptors was evaluated using a docking model. The resul
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Manandhar, Preeti, Bridin Patricia Murnion, Natasha L. Grimsey, Mark Connor, and Marina Santiago. "Do gabapentin or pregabalin directly modulate the µ receptor?" PeerJ 9 (April 12, 2021): e11175. http://dx.doi.org/10.7717/peerj.11175.

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Background Pregabalin and gabapentin improve neuropathic pain symptoms but there are emerging concerns regarding their misuse. This is more pronounced among patients with substance use disorder, particularly involving opioids. Co-ingestion of gabapentinoids with opioids is increasingly identified in opioid related deaths, however, the molecular mechanism behind this is still unclear. We have sought to determine whether pregabalin or gabapentin directly modulates acute μ receptor signaling, or μ receptor activation by morphine. Methods The effects of pregabalin and gabapentin were assessed in H
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Madamba, Samuel G., Paul Schweitzer, and George Robert Siggins. "Dynorphin Selectively Augments the M-Current in Hippocampal CA1 Neurons by an Opiate Receptor Mechanism." Journal of Neurophysiology 82, no. 4 (1999): 1768–75. http://dx.doi.org/10.1152/jn.1999.82.4.1768.

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Most electrophysiological studies of opioids on hippocampal principal neurons have found indirect actions, usually through interneurons. However, our laboratory recently found reciprocal alteration of the voltage-dependent K+current, known as the M-current ( I M), by κ and δ opioid agonists in CA3 pyramidal neurons. Recent ultrastructural studies have revealed postsynaptic δ opiate receptors on dendrites and cell bodies of CA1 and CA3 hippocampal pyramidal neurons (HPNs). Reasoning that previous electrophysiological studies may have overlooked voltage-dependent postsynaptic effects of the opio
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Ji, J., W. Lin, A. Vrudhula, et al. "Molecular Interaction Between Butorphanol and K-opioid Receptor." Obstetric Anesthesia Digest 41, no. 1 (2021): 44. http://dx.doi.org/10.1097/01.aoa.0000732540.18281.53.

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Carpenter, Elisabeth, J. Paul Gent, and Chris Peers. "Opioid receptor independent inhibition of Ca2+ and K+ currents in NG108–15 cells by the K opioid receptor agonist U50488H." NeuroReport 7, no. 11 (1996): 1809–12. http://dx.doi.org/10.1097/00001756-199607290-00024.

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Huh, Joon, Garrett J. Gross, Hiroshi Nagase та Bruce T. Liang. "Protection of cardiac myocytes via δ1-opioid receptors, protein kinase C, and mitochondrial KATP channels". American Journal of Physiology-Heart and Circulatory Physiology 280, № 1 (2001): H377—H383. http://dx.doi.org/10.1152/ajpheart.2001.280.1.h377.

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The objective of the present study was to investigate the role of δ1-opioid receptors in mediating cardioprotection in isolated chick cardiac myocytes and to investigate whether protein kinase C and mitochondrial ATP-sensitive K+(KATP) channels act downstream of the δ1-opioid receptor in mediating this beneficial effect. A 5-min preexposure to the selective δ1-opioid receptor agonist (−)-TAN-67 (1 μM) resulted in less myocyte injury during the subsequent prolonged ischemia compared with untreated myocytes. 7-Benzylidenenaltrexone, a selective δ1-opioid receptor antagonist, completely blocked t
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Nechaykina, Olga V., Denis S. Laptev, Sergei G. Petunov та Andrei S. Radilov. "The effect of β-endorphin on the functional parameters of the isolated heart and lymphatic vessels of the white rat". HERALD of North-Western State Medical University named after I.I. Mechnikov 11, № 2 (2019): 43–48. http://dx.doi.org/10.17816/mechnikov201911243-48.

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Objective. The work is devoted to the comparison of the mechanisms of β-endorphin action in isolated rat heart and lymphatic vessels.
 Materials and methods. The experiments were performed using the Langendorff System perfusion device (Panlab, Spain) and the multichannel wire myograph 620M (DMT). During the study, selective opioid receptor blockers, K + channel blockers were used.
 Conclusion. In the course of experimental studies it was found that the most likely target for β-endorphin in an isolated rat heart are δ-opioid receptors, in isolated lymphatic vessels of a rat - μ- and δ
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Finnegan, Thomas F., Shao-Rui Chen та Hui-Lin Pan. "μ Opioid Receptor Activation Inhibits GABAergic Inputs to Basolateral Amygdala Neurons Through Kv1.1/1.2 Channels". Journal of Neurophysiology 95, № 4 (2006): 2032–41. http://dx.doi.org/10.1152/jn.01004.2005.

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The basolateral amygdala (BLA) is the major amygdaloid nucleus distributed with μ opioid receptors. The afferent input from the BLA to the central nucleus of the amygdala (CeA) is considered important for opioid analgesia. However, little is known about the effect of μ opioids on synaptic transmission in the BLA. In this study, we examined the effect of μ opioid receptor stimulation on the inhibitory and excitatory synaptic inputs to CeA-projecting BLA neurons. BLA neurons were retrogradely labeled with a fluorescent tracer injected into the CeA of rats. Whole cell voltage-clamp recordings wer
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Dissertations / Theses on the topic "K-Opioid receptor"

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Zhang, Weimin, and 張為民. "Cardiac k-opioid receptor: multiplicity, regulation, signal transduction and function." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B3123804X.

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Zhang, Weimin. "Cardiac k-opioid receptor : multiplicity, regulation, signal transduction and function /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19588999.

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卞勁松 and Jin-song Bian. "The role of protein kinase C upon K-opioid receptor stimulation in theheart." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31239900.

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Wood, Michael D. "Role of k-opioid receptor agonist U-50,488H in consummatory successive negative contrast." Fort Worth, Tex. : Texas Christian University, 2006. http://etd.tcu.edu/etdfiles/available/etd-07262006-161404/unrestricted/wood.pdf.

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Yan, Feng. "Molecular mechanisms by which salvinorin A binds to and activates the k-opioid receptor." Cleveland, Ohio : Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1207342013.

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Wood, Malcolm S. "Characterization of opioid binding sites in spinal cord and other tissues." Thesis, Loughborough University, 1988. https://dspace.lboro.ac.uk/2134/25215.

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The binding of [³H]opioid ligands to homogenates prepared from the spinal cords of rat and other species has been studied. Similar numbers of sites were seen in all areas of the cord when measured in a rostrocaudal direction. There was found to be approximately 2 x higher density of sites in the dorsal half of the cord compared with the ventral half. Binding studies suggested a similar relative distribution of mu, delta and kappa sites in all areas of the cord. The results are discussed in relation to the reported distribution of opioid peptides. In the above study the kappa binding site was d
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Bian, Jin-song. "The role of protein kinase C upon K-opioid receptor stimulation in the heart /." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21790863.

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盛建中 and Jianzhong Sheng. "Phosphoinositol/Ca2+ pathway in the cardiac k-opioid receptor: physiological role and alternations upontolerance." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31237654.

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Yu, Xiaochun, and 喻曉春. "Negative modulation of B-adrenoceptor by K-opioid receptor in the heart: signaling mechanisms and clinicalsignificance." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31241323.

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Sheng, Jianzhong. "Phosphoinositol/Ca2+ pathway in the cardiac k-opioid receptor : physiological role and alternations upon tolerance /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19616193.

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Book chapters on the topic "K-Opioid receptor"

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"k and ε opioid receptor binding." In Pharmacology of Opioid Peptides. CRC Press, 1995. http://dx.doi.org/10.1201/9781482264487-8.

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"Antipruritic Activity of a Novel K-Opioid Receptor Agonist, TRK-820." In Itch. CRC Press, 2004. http://dx.doi.org/10.1201/b14233-17.

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"Prospects for a Novel K-Opioid Receptor Agonist, TRK-820, in Uremic Pruritus." In Itch. CRC Press, 2004. http://dx.doi.org/10.1201/b14233-33.

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"8-Epi-Salvinorin B: Crystal Structure and Affinity at the K Opioid Receptor." In Organic Chemistry. Apple Academic Press, 2011. http://dx.doi.org/10.1201/b12874-28.

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"Pharmacological characterization of opioid δ and k receptors." In Pharmacology of Opioid Peptides. CRC Press, 1995. http://dx.doi.org/10.1201/9781482264487-18.

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Racké, K., U. Haas, S. Sperb, et al. "Opioid Inhibition of Oxytocin Release, but not Autoinhibition of Dopamine Release May Involve Activation of Potassium (K+) Channels." In Presynaptic Receptors and Neuronal Transporters. Elsevier, 1991. http://dx.doi.org/10.1016/b978-0-08-041165-1.50093-4.

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