Log in

Relevant bibliographies by topics / Kappa lambda ratio

Contents

Journal articles
Books

Academic literature on the topic 'Kappa lambda ratio'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Kappa lambda ratio.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Kappa lambda ratio"

1

Ambrosino, D. M., M. V. Kanchana, N. R. Delaney, and R. W. Finberg. "Human B cells secrete predominantly lambda L chains in the absence of H chain expression." Journal of Immunology 146, no. 2 (1991): 599–602. http://dx.doi.org/10.4049/jimmunol.146.2.599.

Full text

Abstract:

Abstract Ig H and L chains are independently assembled in B cells and then secreted together as a functional protein. H chains cannot be secreted without assembly to L chains; however, L chains can be secreted in the absence of H chains by both mice and human cells. To examine the influence of H chain expression on human L chain isotype selection (kappa or lambda), we compared the kappa/lambda ratio of L chains unassociated with H chains (free L chains) to the kappa/lambda ratio of L chains associated with H chains. Culture supernatants of human splenocytes were assayed for kappa and lambda L

APA, Harvard, Vancouver, ISO, and other styles

2

Saitta, M., A. Iavarone, N. Cappello, M. R. Bergami, G. C. Fiorucci, and F. Aguzzi. "Reference Values for Immunoglobulin Kappa and Lambda Light Chains and the Kappa/Lambda Ratio in Children's Serum." Clinical Chemistry 38, no. 12 (1992): 2454–57. http://dx.doi.org/10.1093/clinchem/38.12.2454.

Full text

Abstract:

Abstract We analyzed 708 serum samples from healthy children and adolescents by immunonephelometry to obtain reference values for the immunoglobulin kappa (kappa) and lambda (lambda) light chains and for their ratio at a time of life when immunoglobulin synthesis is maturing and continually being stimulated. The lambda chain concentration that is to be maintained throughout the child's life is reached very early, just after 1 year, whereas the concentration of the kappa chains, which increases gradually, reflects the concentration of the immunoglobulins as a whole. These reference values may b

APA, Harvard, Vancouver, ISO, and other styles

3

Rajkumar, S. Vincent, Robert A. Kyle, Terry M. Therneau, et al. "Presence of an Abnormal Serum Free Light Ratio Is an Independent Risk Factor for Progression in Monoclonal Gammopathy of Undetermined Significance (MGUS)." Blood 104, no. 11 (2004): 3647. http://dx.doi.org/10.1182/blood.v104.11.3647.3647.

Full text

Abstract:

Abstract Background: Monoclonal gammopathy of undetermined significance (MGUS) affects 3% of persons age 50 yrs or greater. Reliable predictors of progression of MGUS to myeloma or related malignancy are needed. We hypothesized that the presence of monoclonal unbound (free) kappa or lambda immunoglobulin light chains in MGUS, as detected by an abnormal serum kappa/lambda free light chain (FLC) ratio would indicate clonal evolution in the neoplastic plasma cell and increase risk of progression to malignancy. Methods: Patients (pts) from Southeastern Minnesota with MGUS seen at the Mayo Clinic f

APA, Harvard, Vancouver, ISO, and other styles

4

Levinson, Stanley S. "kappa/lambda index for confirming urinary free light chain in amyloidosis AL and other plasma cell dyscrasias." Clinical Chemistry 37, no. 6 (1991): 1122–26. http://dx.doi.org/10.1093/clinchem/37.6.1122.

Full text

Abstract:

Abstract Primary systemic amyloidosis (AL), a disease involving the deposition of immunoglobulin light chains in tissue, is caused by a plasma cell dyscrasia. In the case of amyloidosis reported here, no monoclonal component was seen upon routine protein electrophoresis of serum or urine nor was a bone marrow analysis positive for AL. Immunofixation electrophoresis did not show a typical paraprotein band but did show, in the gamma region, two large diffuse bands and a lower concentration of oligoclonal-type bands, all of which stained for free lambda but not for free kappa chain. The ratio of

APA, Harvard, Vancouver, ISO, and other styles

5

Anand and Bharty Rolly. "A Study to Assess the Serum Free Light Chain Assay and Urine Protein Immunofixation in the Diagnosis of Patients with Monoclonal Gammopathy: A Retrospective Study." International Journal of Current Pharmaceutical Review and Research 16, no. 03 (2024): 539–43. https://doi.org/10.5281/zenodo.12792685.

Full text

Abstract:

AbstractAim: The aim of the present study was to assess the serum free light chain assay and urine protein immunofixationin the diagnosis of patients with monoclonal gammopathy.Methods: The study included 22 patients, most of whom had monoclonal gammopathies and were hospitalizedat Jawaharlal Nehru Medical College, Bhagalpur, Bihar, India for one year.Results: The median age of the patients (13 men and 9 women) was 64 years. 3 patients were suffering only fromLCDD λ and 1 patient was suffering from non-secretory myeloma with FLC κ. 11 patients had multiple myeloma(6 with IgG &kapp

APA, Harvard, Vancouver, ISO, and other styles

6

Renckens, A. L., M. J. Jansen, P. J. van Munster, C. M. Weemaes, and J. A. Bakkeren. "Nephelometry of the kappa/lambda light-chain ratio in serum of normal and diseased children." Clinical Chemistry 32, no. 12 (1986): 2147–49. http://dx.doi.org/10.1093/clinchem/32.12.2147.

Full text

Abstract:

Abstract We determined, immunonephelometrically, the ratio between the two types of light chains of immunoglobulins, kappa and lambda, in serum of 94 children, ages 0.4 to 14 years, with no manifest immunological disorders. Children with an abnormal protein pattern by immunoelectrophoresis show other values for this ratio than do children in this reference group. We also determined the ratios for children with IgA deficiency (I), juvenile rheumatic arthritis (II), and acute lymphoblastic leukemia (III). Children with I show the same kappa/lambda ratios as for the children in the reference grou

APA, Harvard, Vancouver, ISO, and other styles

7

Whicher, J. T., M. Wallage, and R. Fifield. "Use of immunoglobulin heavy- and light-chain measurements compared with existing techniques as a means of typing monoclonal immunoglobulins." Clinical Chemistry 33, no. 10 (1987): 1771–73. http://dx.doi.org/10.1093/clinchem/33.10.1771.

Full text

Abstract:

Abstract Using automated measurements of kappa and lambda light chains and IgG, IgA, and IgM, we assessed the utility of the kappa/lambda ratio and the heavy chain/light chain ratio in characterizing monoclonal immunoglobulins previously identified by sensitive electrophoresis on agarose gel and typed by immunofixation or immunoelectrophoresis. We examined 348 selected samples, of which 165 contained monoclonal components, finding that 93.4% were detected and 89% correctly typed by this approach. Eight samples were shown to contain monoclonal light chains that were not visible as bands on elec

APA, Harvard, Vancouver, ISO, and other styles

8

Reeves, W. H., and S. A. Ali. "Preferential use of lambda L chain in lamin B autoantibodies." Journal of Immunology 143, no. 11 (1989): 3614–18. http://dx.doi.org/10.4049/jimmunol.143.11.3614.

Full text

Abstract:

Abstract The generation of lamin B autoantibodies was examined in a patient with SLE. Lamin B autoantibodies in this individual's serum were almost entirely IgG1 lambda at the onset of the autoimmune response. There was no evidence of IgM to IgG class switching, and no apparent diversification of the autoantibody response over the next 2 yr. The kappa/lambda L chain ratio of the lamin B autoantibodies was 0.13 by ELISA, with a kappa/lambda ratio of 0.70 for the patient's total IgG. In contrast, anti-histone autoantibodies in the patient's serum contained primarily kappa L chain. The kappa/lamb

APA, Harvard, Vancouver, ISO, and other styles

9

Hungria, Vania T. M., Petros Kampanis, Mark T. Drayson, et al. "Comparison of Kappa & Lambda Freelite to Total Kappa & Lambda Immunoassays for the Detection of Monoclonal Gammopathies, Both As Standalone Tests and Alongside Serum Protein Electrophoresis." Blood 124, no. 21 (2014): 5705. http://dx.doi.org/10.1182/blood.v124.21.5705.5705.

Full text

Abstract:

Abstract Introduction Monoclonal gammopathies are a disparate group of diseases from benign to malignant which are characterised by the proliferation of a single B cell clone that produces a homogeneous monoclonal immunoglobulin (M-Ig). The method of detection and quantification of the M-Ig will depend upon whether it is an intact immunoglobulin or present as serum free light chain only. Historically serum (SPEP) and urine (UPEP) electrophoresis were considered the gold standard for identifying intact M-Ig and FLC respectively. In 2001 the introduction of the Freelite test changed the diagnost

APA, Harvard, Vancouver, ISO, and other styles

10

Abbi, Kamal Kant Singh, Guido J. Tricot, Margarida Silverman, Kalyan Nadiminti, and Matthew Krasowski. "Potential Pitfalls of Serum Free Light Chain Analysis to Assess Treatment Response for Multiple Myeloma." Blood 126, no. 23 (2015): 5308. http://dx.doi.org/10.1182/blood.v126.23.5308.5308.

Full text

Abstract:

Abstract Background The serum free light chain (FLC test) allows measurement of low concentrations of FLC. Post-transplantation, especially after tandem autologous transplants and consolidation therapy, the immune system is often extremely suppressed and its recovery is disorganized. Patients and Methods This study was limited to patients with multiple myeloma, plasma cell leukemia and amyloidosis, who received autologous transplantation and consolidation therapy at the University of Iowa Hospitals and clinics. Most of these patients had already received some form of induction therapy with IMI

APA, Harvard, Vancouver, ISO, and other styles

More sources

Books on the topic "Kappa lambda ratio"

1

Macartney, Ian. A clinical study of known paraproteinaemias to establish kappa/lambda ratios. The Author], 1993.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!