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Journal articles on the topic 'Karaya gum and HPMC K100M'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Naveen, Kumar HR, Kumar P. Ashok, V. Kulkarni Suresh, and K. Manjunath. "Development and Evaluation of Floating Sustained Release Bilayer Tablets Containing Drotaverine HCl." American Journal of PharmTech Research 12, no. 06 (2022): 62–74. https://doi.org/10.5281/zenodo.7407644.

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ABSTRACT Bilayer floating tablets of Drotaverine HCL were developed by direct compression method. Immediate release layer contains 20 mg of drug and super disintegrant sodium starch glycolate, serves the purpose of loading dose. Sustained release layer contained HPMC K100, natural polymers like xanthan gum, guar gum, karaya gum release the drug for 12 hours’ time. Sodium bicarbonate and citric acid are used to produce effervescence. Floating lag time of optimized tablet is 92 sec, whereas floating duration is more than 12 hours. FTIR results revealed that there was no interaction between

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2

Sana, Nusrat Praween* Dr. Kaushal Kishore Chandrul Pankaj Chasta. "Formulation And Characterization of Sustain Release Drug Delivery of Glycopyrrolate and Formoterol for The Treatment of Chronic Obstructive Pulmonary Disease (COPD)." International Journal of Pharmaceutical Sciences, no. 12 (December 22, 2024): 2853–69. https://doi.org/10.5281/zenodo.14543522.

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The objective of the current work was to formulate and evaluate sustained release matrix tablets of Glycopyrrolate and Formoterol. The tablet was prepared by wet granulation Method using Xanthan gum, Karaya gum and HPMC K100M. Compatibility studies between Drug and Excipients showed that DS showed no significant change. The FT-IR studies showed that there is no interaction between the drug and excipients, as all peaks corresponding to different functional groups of pure drug were present in the drug-excipient mixture. All the formulations and their mixture showed acceptable flow properties lik

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3

Rangasamy, Manivannan, Venkata Krishna Reddy Palnati, and Lakshmi Narayana Rao Bandaru. "Formulation development and evaluation of voriconazole sustained release tablets." International Current Pharmaceutical Journal 2, no. 10 (2013): 165–69. http://dx.doi.org/10.3329/icpj.v2i10.16410.

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The present study involves in the formulation and evaluation of sustained release tablets of Voriconazole (250mg). The objective of the present study was to formulate Voriconazole sustained release tablets by wet granulation method by using natural (Xanthan gum, Karaya gum) and semi synthetic polymers (HPMC K100M). Lactose was used as diluting agent, Magnesium stearate was used as a lubricant and Talc was used as a glident. These sustained release tablets can release the drug up to 12 hours in predetermined rate. The formulated powder blend was evaluated for bulk density, tapped density, compr

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4

Ashok Kumar, P., and S. Damodar Kumar. "EFFECT OF HYDROPHILIC POLYMERS ON CONTROLLED RELEASE MATRIX TABLETS OF ACYCLOVIR." INDIAN DRUGS 50, no. 01 (2013): 42–49. http://dx.doi.org/10.53879/id.50.01.p0042.

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Acyclovir was formulated as oral controlled release matrix tablets using natural and synthetic polymers separately or in combinations. Tablets were prepared by direct compression method. The tablets were evaluated to thickness, weight variation test, drug content, hardness, friability and in vitro release studies.All the formulations showed compliance with pharmacopoeal standards. The tablets prepared with various combination of hydroxy propyl methylcellulose (HPMC K100), locust bean gum (LBG) and karaya gum (KG) failed to produce the desired controlled release. Dissolution studies indicated t

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5

Shubham, Solanke* Hemant Sawarkar Aijaz Sheikh Kailash Biyani. "Design And Characterization of Gastroretentive Drug Delivery System of a Model Drug." International Journal of Pharmaceutical Sciences 3, no. 6 (2025): 734–37. https://doi.org/10.5281/zenodo.15596005.

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This study focused on developing a gastroretentive drug delivery system (GRDDS) for lamotrigine, an antiepileptic drug, using floating tablets formulated with curdlan gum and hydroxypropyl methylcellulose (HPMC K100M) as matrix-forming polymers, alongside sodium bicarbonate as a gas-generating agent. The objective was to enhance gastric retention and achieve sustained drug release. Eight formulations (F1–F4 with curdlan gum, F5–F8 with HPMC K100M) were prepared via direct compression and evaluated for physicochemical properties, buoyancy, swelling, in-vitro drug release, kinetics,

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Soujanya, Anand Kumar Y, and Yashashwini B. "Design, optimization and in vitro characterization of valsartan loaded floating tablets." GSC Biological and Pharmaceutical Sciences 29, no. 3 (2024): 373–85. https://doi.org/10.30574/gscbps.2024.29.3.0433.

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The present work was aim to design and optimize floating drug delivery systems of Valsartan using HPMC K15M, HPMC K100M, Guar gum as polymer and sodium bicarbonate as a gas generating agent. The tablets were prepared by direct compression method. Response surface methodology (RSM) was adapted using Box Behnken Design (BBD) using amount of HPMC K15M (X1), HPMC K100M (X2) and Guar gum (X3) were selected as independent variables, buoyancy time (Y1) and t50 (Y2) selected as dependent variables. All the designed 15 trial batches of formulations were evaluated for precompression, postcompression, dr

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Soujanya, Kumar Y. Anand, and B. Yashashwini. "Design, optimization and in vitro characterization of valsartan loaded floating tablets." GSC Biological and Pharmaceutical Sciences 29, no. 3 (2024): 373–85. https://doi.org/10.5281/zenodo.14915723.

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The present work was aim to design and optimize floating drug delivery systems of Valsartan using HPMC K15M, HPMC K100M, Guar gum as polymer and sodium bicarbonate as a gas generating agent. The tablets were prepared by direct compression method. Response surface methodology (RSM) was adapted using Box Behnken Design (BBD) using amount of HPMC K15M (X1), HPMC K100M (X2) and Guar gum (X3) were selected as independent variables, buoyancy time (Y1) and t50 (Y2) selected as dependent variables. All the designed 15 trial batches of formulations were evaluated for precompression, postcompression, dr

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8

Sari, Shelinia Prima, Angi Nadya Bestari, and T. N. Saifullah Sulaiman. "Optimasi Formula Tablet Floating Famotidin Menggunakan Kombinasi Matriks Gum Xanthan dan Hidroksi Propil Metil Selulosa K100M." Majalah Farmaseutik 15, no. 2 (2019): 86. http://dx.doi.org/10.22146/farmaseutik.v15i2.46878.

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Famotidin adalah obat antihistamin H2 yang digunakan dalam pengobatan penyakit tukak lambung (peptic ulcer), tukak duodenal, ataupun keadaan hipersekresi yang patologis. Tablet floating famotidin dapat meningkatkan bioavailabilitas dengan mempertahankan waktu tinggal tablet dalam lambung dan mendekatkan famotidin pada tempat absorpsinya pada lambung bagian atas. Penelitian ini bertujuan untuk mengetahui komposisi optimum HPMC K100M serta gum xanthan dan pengaruh variasi keduanya terhadap sifat fisik granul dan tablet floating famotidin. Pembuatan delapan formula tablet floating famotidin mengg

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9

Djebbar, Mohamed, Nacéra Chaffai, Fatiha Bouchal, and Noureddine Aouf. "Effervescent floating tablets of metformin HCl developed by melt granulation. Part I: Effect of hydrophilic polymer on biopharmaceutical properties." GSC Biological and Pharmaceutical Sciences 6, no. 2 (2019): 052–67. https://doi.org/10.5281/zenodo.4303950.

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In the present study which the aim to evaluate the effect of hydrophilic polymer on the biopharmaceutical properties of metformin hydrochloride floating tablets, we have prepared floating systems using melt granulation, according to effervescent approach. Two hydrophilic polymers are used at various concentrations (10, 12.5, 15 and 17.5%), Acacia gum and hydroxypropylmethylcellulose (HPMC) at three viscosity grades (K4M, K15M and K100M). In addition to the satisfactory physical parameters, the evaluation of buoyancy and <em>in vitro</em> dissolution of floating developed systems reve

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10

Andini, Septia, Siti Sa’diah, and Suci Puspa. "Preparasi dan Karakteristik Floating Tablet Ekstrak Daun Jambu Biji (Psidium guajava L.) dengan Variasi Kombinasi Xanthan Gum dan HPMC." Jurnal Sains dan Kesehatan 4, no. 4 (2022): 370–78. http://dx.doi.org/10.25026/jsk.v4i4.1226.

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Floating drug delivery system (FRDDS) is a new drug delivery system that is intended to prolong the time of drugs in the stomach. One form of the gastroretentive system is a floating tablet, which can float and stay in the stomach for some time. Preparations with this system are suitable for use in drugs that have an action on the stomach. Gastritis is defined as an inflammation or swelling of the inner lining of the stomach. Guava leaves are proven to have active ingredients that can act as anti-ulcers. This study aims to formulate floating tablets and determine the optimal combination of HPM

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11

G., Mahesh *. "FORMULATION DEVELOPMENT AND EVALUATION OF MATRIX TABLETS OF PROPRANOLOL HCL BY USING RELEASE RETARDING AGENTS." Journal of Pharma Research 7, no. 3 (2018): 31–36. https://doi.org/10.5281/zenodo.1209341.

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<strong><em>ABSTRACT</em></strong> <strong><em>T</em></strong><em>he main aim of the present work is to formulate and develop matrix tablets of Propranolol HCl. Selected suitable method for preparation process of Direct compression method for matrix tablets of Propranolol HCl by using varying concentrations of HPMC K4M, HPMC K100M, sodium alginate and Xanthan gum as a release retarding agents, dibasic calcium phosphate, Microcrystalline cellulose as diluents, talc and magnesium stearate as glidant and lubricant. Excipients compatibility studies were carried out by Stability studies and FT-IR s

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12

Mhaske, Padmaja K. "Formulation and Evaluation of Sustained Release Matrix Tablet Metformin Hydrochloride." International Journal for Research in Applied Science and Engineering Technology 11, no. 6 (2023): 3535–45. http://dx.doi.org/10.22214/ijraset.2023.54350.

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Abstract: The present study outlines a systematic approach for designing and development of Metformin Hydrochloride sustained release matrix tablets. Different formulations were formulated by wet granulation technique using Xanthan gum and HPMC K100M as polymers along with other excipients The formulations were evaluated for their physicochemical properties.

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13

Reddy, P. Srikanth, V. Alagarsamy, and P. Subhash Chandra Bose. "Formulation and In-Vitro Evaluation of Amlodipine Besylate Floating Tablets Using Different Polymers." International Journal of Research and Review 10, no. 9 (2023): 500–510. http://dx.doi.org/10.52403/ijrr.20230951.

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Gastric-retentive amlodipine besylate effervescent tablets have been developed using a variety of hydrophilic polymers. Formulations were developed using different grades of different concentrations of polymer. H. HPMC K4M, HPMC K15M, HPMC K100 and xanthan gum were used as polymeric substances. The formulated mixtures have been subjected to various pre-formulation studies and flow properties, and all formulations show that the powder mixtures have good flow properties. Among all formulations, drug release was delayed for the desired period, H. 12 hours, for the HPMC K100 formulation as a polym

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14

Sreenivasa, Reddy N. Mahendra Kumar CB Ramesh A. "FORMULATION OF GASTRO RETENTIVE MATRIX TABLETS FOR ANTIHYPERTENSIVE DRUGS USING NATURAL GUMS AND LOW-DENSITY POLYMERS: EFFECT OF FORMULATION FACTORS ON IN VITRO DISSOLUTION RATES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 04 (2019): 8346–60. https://doi.org/10.5281/zenodo.2650760.

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<em>The objective of the study was to develop Gastro retentive matrix tablets for antihypertensive drugs. The matrix tablets of antihypertensive drug captopril with 12 formulations coded as F1 to F12 with variant ratios of polymer were prepared in the preliminary studies by direct compression method. Hydrophilic and hydrophobic low density polymers like HPMC M15K and HPMC M4K and natural gums like Karaya gum, Xanthan gum, Pullulan gum, Gellan gum and Guar gum were used. The pre-compression parameters, and compatibility of drug with various excipient was studied using HPTLC, FTIR and DSC. The t

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15

R. Nagaraju and Rajesh Kaza. "Formulation and Evaluation of Bilayer Sustained Release Tablets of Salbutamol and Theophylline." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 3 (2009): 638–46. http://dx.doi.org/10.37285/ijpsn.2009.2.3.7.

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Salbutamol and theophylline are available in conventional dosage forms, administered four times a day, leading to saw tooth kinetics and resulting in ineffective therapy. The combination of these two drugs in a single dosage form will enhance the patient compliance and prolong bronchodilation. Various polymers, such as hydroxy propyl methylcellulose K4M (HPMC- K4M), hydroxy propyl methylcellulose K100M (HPMC- K100M), xanthan gum, ethyl cellulose and hydroxy propyl methylcellulose phthalate (HPMC-P) were studied. HPMC-P and HPMC- K4M were found to be best in controlling the release. In-vitro di

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16

Tosha, Sumaiya Mehjabin, Ashima Aziz, Sharmin Jahan Chisty, Md Asaduzzaman, and Mohiuddin Ahmed Bhuiyan. "Development and in vitro evaluation of pulsatile drug delivery system of enalapril maleate." Bangladesh Pharmaceutical Journal 18, no. 1 (2015): 66–71. http://dx.doi.org/10.3329/bpj.v18i1.23519.

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Pulsatile drug delivery of enalapril maleate is one such system that, by delivering drug at the right time, right place and in right amounts, holds good promises of benefit to the patients suffering from hypertension. The basic design involves the preparation of cross linked hard gelatin capsules using formaldehyde. Then the drug diluent mixtures were prepared and loaded which was separated by using hydrogel plug of polymers of different grades such as HPMC 50 cps, HPMC 100 cps, HPMC K4M, HPMC K15M, HPMC K100M, xanthan gum, carbopol 971 and sodium CMC at different amount (100 and 120 mg). Prep

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17

Djebbar, Mohamed, Nacéra Chaffai, and Fatiha Bouchal. "Development of Floating Tablets of Metformin HCl by Thermoplastic Granulation. Part II: In Vitro Evaluation of the Combined Effect of Acacia Gum/HPMC on Biopharmaceutical Performances." Advanced Pharmaceutical Bulletin 10, no. 3 (2020): 399–407. http://dx.doi.org/10.34172/apb.2020.048.

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Purpose: The aim of this study was to evaluate the combined effect, acacia gum(AG)/ hydroxypropylmethylcellulose (HPMC), on biopharmaceutical performances of floating tablets of metformin hydrochloride (MTH) prepared by thermoplastic granulation using stearic acid. Methods: We have prepared the matrixes using AG/HPMC as a polymer combination. This combination of polymers which represents 15% of the total mass of tablet was used at various ratios 3:1, 1:1, 1:3, with two viscosity grade of HPMC (k15M and k100M). The developed matrixes have been evaluated for their pharmacotechnical and biopharma

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18

Gangadharappa, H. V., M. Rahamath-Ulla, T. M. Pramod-Kumar, and F. Shakeel. "Floating drug delivery system of verapamil hydrochloride using karaya gum and HPMC." Clinical Research and Regulatory Affairs 27, no. 1 (2010): 13–20. http://dx.doi.org/10.3109/10601331003604762.

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19

Kusuma, M. P., та Manisha N. S. Mogili. "Formulation and Development of β-glucan Hydrogel using Design of Experiments (DOE)". INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, № 03 (2022): 1266–74. http://dx.doi.org/10.25258/ijddt.12.3.56.

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β-Glucan, an endogenous carbohydrate, is a key functional ingredient found in barley and oats and a major component of microbiological and plant cell walls. With no severe adverse effects, it has anti-tumor, diabetic lowering, wound healing, anti-aging and anticholesteremic effects. Twenty formulations were prepared using different polymers like carbapol 934, hydroxypropyl methylcellulose (HPMC) K100M, HPMC K15M, guar gum and xantham gum. F1 formulation exhibited satisfactory results with respect to in-vitro drug release, spreadability, extrudability viscosity and drug content. In order to opt

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20

Kukkdapu, Pavan Kumar* Konda Mayuri Bandigari Parijatha Eslavath Ravindar Naik Kamatam Prashanthi. "FORMULATION AND EVALUATION OF CIMETIDINE GASTRORETENTIVE DRUG DELIVERY TABLETS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 05 (2018): 4651–61. https://doi.org/10.5281/zenodo.1258050.

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<em>Gastroretentive drug delivery systems are the systems which are retained in the stomach for a longer period of time and thereby improve the bioavailability of drugs. Cimetidine, an anti-ulcer drug, suffers from poor bioavailability (50%), as cimetidine is very less soluble in alkaline P<sup>H</sup>. cimetidine used in combination with antacids promotes local delivery of these drugs to the receptor of the parietal cell wall. Local delivery also increases bioavailability at the stomach wall receptor site and increases the efficacy of drugs to reduce acid secretion. Thus, the present work is

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Y, Shravan Kumar, Shireesha G, and Harika S. "Formulation and Evaluation of Metoprolol Tartrate Sustained Release Matrix Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology 12, no. 5 (2019): 4865–671. http://dx.doi.org/10.37285/ijpsn.2019.12.5.7.

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The objective of the present work was to develop sustained release matrix tablets of Metoprolol tartrate using different polymers viz. Guar gum, Xanthan gum, Kondagogu gum and HPMC K100M. The release rates were modulated by combination of two different rates controlling material and triple mixture of two different rate controlling materials. After evaluation of physical properties of tablet, the in-vitro release study was performed in phosphate buffer pH 6.8 up to 12 hrs. Dissolution data was analyzed for release kinetics. It was observed that matrix tablets contained polymer Xanthan gum was s

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Sharma, Hemanth Kumar, and Sambasiva Rao P. "Formulation and in vitro evaluation of eprosartan mesilate floating tablets using natural and synthetic polymers." International Journal of Research in Pharmaceutical Sciences 15, no. 4 (2024): 150–64. https://doi.org/10.26452/ijrps.v15i4.4767.

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The extent of therapeutic advantages led to the development of Controlled drug delivery systems, which could be taken once a day. The prime objectives of these types of dosage forms would be single dose, which releases the active ingredient over an extended period of time. Secondly, it should release the active entity directly to the site of action, thus, minimizingor eliminating side effects. In the present manuscript, Eprosartan mesilate was selected as drug of choice to design an effervescent gastric floating matrix tablets (EGFMT) using natural polymers as well as synthetic polymers as mat

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Bandameedi, Ramu, and Shanmunga Pandiyan P. "FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING BIOADHESIVE TABLETS OF HYDROCHLORTHIAZIDE." Asian Journal of Pharmaceutical and Clinical Research 10, no. 5 (2017): 150. http://dx.doi.org/10.22159/ajpcr.2017.v10i5.17137.

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Objective: Floating bioadhesive tablets of hydrochlorothiazide were developed to prolong gastric residence time leading to an increase in drugbioavailability where here a combination of floating and bioadhesion mechanism is combined.Methods: Tablets are prepared by direct compression technique using polymers xanthan gum, carbopol 974 P, HPMC K15M, HPMC K100M, magnesiumStearate USP-NF (Avicel PH 102), microcrystalline cellulose Ph 102, Talc, and sodium bicarbonate.Results: Tablets were evaluated for their physical characteristics, namely, hardness, thickness, friability and weight variation, dr

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Kumari, Satish, Anchal Puri, Dhruv Dev, DN Prasad, and ,. Monika. "A review on polymers in natural or modified form used in sustained release tablet." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 870–73. http://dx.doi.org/10.22270/jddt.v9i3-s.2843.

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Tablet is a solid dosage form which is used to deliver the drug to the body to make pharmacological action. The oral dosage form should disperse into small particles to deliver active ingredients in the body, the disperse time of the dosage form depends on the ingredients which are used in the tablet. To make the tablet disintegrate slow usually sustained release agents are used. The sustained release tablets helps in maintaining the drug concentration in the body for the higher time. In this review article various polymers of natural origin and their modified forms are studied, which can be u

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Harish Choodappa and Subramanian Somaskandan. "Formulation and evaluation of bilayer tablets: Glimepiride in floating drug delivery and Metformin in sustained release." International Journal of Research in Pharmaceutical Sciences 10, no. 3 (2019): 1602–7. http://dx.doi.org/10.26452/ijrps.v10i3.1319.

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In this study, we aimed to prepare bilayer tablets of Glimepiride in floating drug delivery and Metformin in sustained release formulation. Glimepiride is chosen in floating drug delivery to overcome the gastric irritation and gastric emptying time. Glimepiride was prepared by different polymers such as guar gum, xanthan gum, carbopol and sodium bicarbonate act as effervescent agent, and other excipients were mixed and compressed by direct compression as the first layer. Metformin was chosen in sustained release to reduce dose frequency using different polymer HPMC K100M, methylcellulose, PVP

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Arun, Jagdish K., Dharmajit Pattanayak, Ramesh Adepu, C. M. Hossain, B. Shrivastava, and Ramya Sri Sura. "Formulation and Evaluation of Floating and Mucoadhesive Tablets Containing Rosiglitazone." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 145–54. http://dx.doi.org/10.22270/jddt.v9i4-s.3267.

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In this present study, floating mucoadhesive tablets of Rosiglitazone were formulated to improve the gastric retention time and overall bioavailability. Different mucoadhesive polymers like HPMC K200 M, Na CMC, Carbopol 974P, Karaya gum, Chitosan and Xanthan gum were selected to formulate the tablets. Various formulations were prepared by using these polymers in different concentration. The pre-compression blend of Rosiglitazone mucoadhesive tablets were characterized with respect to angle of repose, bulk density, tapped density, carr’s index and hausner’s ratio and all the results indicated t

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Kothiya, Olvishkumar M., Bhavana A. Patel, Kunal N. Patel, and Madhubhai M. Patel. "FORMULATION AND CHARACTERIZATION OF SUSTAINED RELEASE MATRIX TABLETS OF IVABRADINE USING 32 FULL FACTORIAL DESIGN." International Journal of Applied Pharmaceutics 10, no. 1 (2018): 59. http://dx.doi.org/10.22159/ijap.2018v10i1.21584.

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Objective: Ivabradine (IB) is anti-Ischemic drug and used for the symptomatic management of stable angina pectoris. IB acts by reducing the heart rate in a mechanism different from beta blockers and calcium channel blockers, two commonly prescribed anti-anginal drugs. IB has a short biological half-life and the dose of 5/7.5 mg twice a day. In this present study, an attempt has been made to prepare sustained release tablet of IB to achieve the desired drug release.Methods: The sustained release polymers, hydroxypropyl methylcellulose K100M (HPMC K100M), guar gum (GG) and xanthan gum (XG) were

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Bomma, Ramesh, Rongala Swamy Naidu, Madhusudan Yamsani, and Kishan Veerabrahma. "Development and evaluation of gastroretentive norfloxacin floating tablets." Acta Pharmaceutica 59, no. 2 (2009): 211–21. http://dx.doi.org/10.2478/v10007-009-0019-6.

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Development and evaluation of gastroretentive norfloxacin floating tabletsFloating matrix tablets of norfloxacin were developed to prolong gastric residence time, leading to an increase in drug bioavailability. Tablets were prepared by the wet granulation technique, using polymers such as hydroxypropyl methylcellulose (HPMC K4M, HPMC K100M) and xanthan gum. Tablets were evaluated for their physical characteristics,viz., hardness, thickness, friability, and mass variation, drug content and floating properties. Further, tablets were studied forin vitrodrug release characteristics for 9 hours. Th

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Kondewad, Pavan P. "Formulation and Evaluation of Gastroretentive Floating Tablets of Glipizide." International Journal for Research in Applied Science and Engineering Technology 11, no. 6 (2023): 1718–34. http://dx.doi.org/10.22214/ijraset.2023.53946.

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Abstract: The present study outlines a systematic approach for designing and development of Glipizide floating tablets to enhance the bioavailability and therapeutic efficacy of the drug. Floating tablets of Glipizide have shown controlled release thereby proper duration of action at a particular site and are designed to prolong the gastric residence time after oral administration. Different formulations were formulated by wet granulation technique using HPMC K100M (floating agent) and Xanthan gum as polymers along with sodium bicarbonate as gas generating agent. The formulations were evaluate

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Kubra, Kol, Kızıltas Hakan, Tekın Taner, and Gun Gokay. "MODIFICATION OF DISSOLVING STUDIES OF GLİCLAZİDE IN LONG RELEASE TABLET FORM USING DIFFERENT POLYMERS." World Journal of Pharmaceutical Science and Research 2, no. 6 (2023): 09–29. https://doi.org/10.5281/zenodo.10931621.

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The main purpose of this study is to obtain an long release tablet formulation of gliclazide utilizing wet granulation production method after evaluation of different polymer structures. In order to provide the long release profile of the gliclazide, trial studies were carried out with xanthan gum, hydroxypropylmethylcellulose (HPMC K100M), povidone K30 and povidone K90 polymers, which have different viscosity properties. Dissolution rate (In vitro) test was applied to each trial run. In this study, Diamicron MR 60 mg Tablet was used as reference product for dissolution rate tests. As a result

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Radhika, Parasuram Rajam, Nishala N, Kiruthika M, and Sree Iswarya S. "DESIGN AND EVALUATION OF INTRAGASTRIC BUOYANT TABLETS OF VENLAFAXINE HYDROCHLORIDE." Asian Journal of Pharmaceutical and Clinical Research 10, no. 5 (2017): 166. http://dx.doi.org/10.22159/ajpcr.2017.v10i5.16948.

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Objective: The present study was undertaken to prolong the release of orally administered drug. The aim is to formulate, develop, and evaluate theintragastric buoyant tablets of venlafaxine hydrochloride, which releases the drug in a sustained manner over a period of 12 hrs. Different formulationswere formulated using the polymers Carbopol 934 P, xanthan gum, hydroxypropyl methylcellulose (HPMC K100M) with varying concentration ofdrug: Polymer ratio of 1:1, 1:1.5, 1:2, in which sodium bicarbonate acts as gas generating agent, and microcrystalline cellulose as a diluent.Methods: The tablets wer

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Malviya, Vedanshu, Mukund Tawar, Prashant Burange, and Ritu Bairagi. "Preparation and Characterization of Gastroreten-tive Sustained Release In-situ Gel of Lafutidine." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 15, no. 6 (2022): 6216–28. http://dx.doi.org/10.37285/ijpsn.2022.15.6.4.

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Background: The in-situ solutions, which float in the gastrointestinal region after gelation, is suited for long-term drug release. In this study, natural and synthetic polymers were used to try to build a Gastro-Retentive controlled release in-situ gel. To modulate the rate of drug distribution and increase bioavailability and stability, gastro-retentive controlled release in-situ gels were prepared.  Materials and Methods: For this project, 32 factorial designs were chosen. The two independent variables were sodium alginate (X1) and the ratio of HPMC K100M: Gellan Gum (X2) was preserve

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S., Sivaranjani*1 K. L. Senthil kumar2 G. Ranjani1. "Formulation And Evaluation Of Clarithromycin Gastroretentive Floating Tablets For Site-Specific Drug Delivery." International Journal in Pharmaceutical Sciences 2, no. 10 (2024): 896–912. https://doi.org/10.5281/zenodo.13944224.

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Clarithromycin is a macrolide antibiotic it is used to treat a wide variety of bacterial infections this medication can also be used in combination with anti-ulcer medications to treat certain types of stomach ulcers. Clarithromycin often used in treating infection caused by Helicobacter pylori (H. pylori). These infections require the drug to remain in contact with the stomach lining for an extended period to be effective. GRDDS represent a cutting-edge advancement in pharmaceutical technology, designed to increase the time a drug spends in the stomach and upper GI tract. By prolonging gastri

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Suhaidi, Danni, Yao-Da Dong, Paul Wynne, Karen P. Hapgood, and David A. V. Morton. "Bulk Flow Optimisation of Amorphous Solid Dispersion Excipient Powders through Surface Modification." Pharmaceutics 15, no. 5 (2023): 1447. http://dx.doi.org/10.3390/pharmaceutics15051447.

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Particulate amorphous solid dispersions (ASDs) have been recognised for their potential to enhance the performance of various solid dose forms, especially oral bioavailability and macromolecule stability. However, the inherent nature of spray-dried ASDs leads to their surface cohesion/adhesion, including hygroscopicity, which hinders their bulk flow and affects their utility and viability in terms of powder production, processing, and function. This study explores the effectiveness of L-leucine (L-leu) coprocessing in modifying the particle surface of ASD-forming materials. Various contrasting

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Mohapatra, Prasanta Kumar, Ch Prathibha, Vivek Tomer, Mandeep Kumar Gupta, and Satyajit Sahoo. "DESIGN AND DEVELOPMENT OF LOSARTAN POTASSIUM FLOATING DRUG DELIVERY SYSTEMS." International Journal of Applied Pharmaceutics 10, no. 6 (2018): 168. http://dx.doi.org/10.22159/ijap.2018v10i6.28782.

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Objective: The current study was projected to prepare a losartan potassium gastroretentive drug delivery system (GRDDS) of floating tablets was planned to enhance the gastric residence time, thus prolong the drug release.Methods: Effervescent floating matrix tablets of losartan potassium were prepared by direct compression technique using polymers like HPMC k4m, guar gum, and gum karaya, with lubricants magnesium stearate and talc. In the present study, sodium bicarbonate was incorporated as a gas generating agent. Total nine formulations were designed and evaluated for pre-compression paramet

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B., Prabhakar Reddy and D.V. R. N. Bhikshapathi*. "DESIGN AND EVALUATION OF EXTENDED RELEASE TRILAYERED MATRIX TABLETS OF SELEGILINE HCL." Indo American Journal of Pharmaceutical Sciences 04, no. 08 (2017): 2321–33. https://doi.org/10.5281/zenodo.844618.

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The present investigation was aimed for the formulation and evaluation of trilayer matrix tablets of Selegiline HCl used in the treatment of depression and in the therapy of Parkinson disease. Twenty seven formulations (F1-F27) for middle layer were prepared by direct compression method using 33 Response surface method (3 variables and 3 levels of polymers) by using Design of experiment software with natural polymers like Locust Bean Gum, Karaya, HPMC K 15M. The barrier layers was formulated employing hydrophobic swellable polymer natural wax i.e carnauba wax the swelling erosion modeling fill

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Thakare, Eknath B., Prashant S. Malpure, Avish D. Maru, and Yashpal M. More. "Formulation and Evaluation of Mucoadhesive Buccal Tablet of Repaglinide." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 415–24. http://dx.doi.org/10.22270/jddt.v9i4-a.3488.

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The aim of present investigation was formulation and evaluation of mucoadhesive buccal tablet of Repaglinide to study the effect of different polymers on release profile of drug for prolonged release. In this study mucoadhesive buccal tablet were prepared by direct compression method. Various rheological characteristics of the powder bed like bulk density, compressibility index, and angle of repose were evaluated and studied. Mucoadhesive buccal tablets were compressed on a 8 station mini press using 10 mm flat faced punches and were all assessed for weight variation, hardness, thickness, perc

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Divyashree, P.1 Nagendra R.2 Nanditha V. V.3 Venkatesh4 K. Hanumanthachar Joshi5. "Formulation And Evaluation of Floating Drug Delivery System of Benazepril." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 351–61. https://doi.org/10.5281/zenodo.14050296.

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The research focuses on developing a floating drug delivery system for Benazepril, aimed at enhancing its absorption and prolonging gastric residence time, thereby improving bioavailability. Floating drug delivery systems (FDDS) maintain buoyancy in gastric fluids, allowing for extended action and reduced dosing frequency. The formulation of floating tablets utilized Carbopol 940, Guar gum, and HPMC K100M as polymers through direct compression, resulting in nine Formulations (F1-F9). Preformulation parameters adhered to pharmacopoeial standards, and FTIR studies confirmed no incompatibility be

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Pandey, Garima, Surendra Dangi, and Bhaskar Kumar Gupta. "Design, Development and Characterization of Novel Ranitidine-Loaded Mucoadhesive Delivery System." International Journal of Medical & Pharmaceutical Sciences 14, no. 05 (2024): 01–10. https://doi.org/10.31782/ijmps.2024.14501.

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Aim: The study aims to develop and evaluate floating tablet formulations of ranitidine to overcome its short half-life (1.2–1.9 hours) and maintain stable plasma drug levels. This approach seeks to enhance drug bioavailability through gastroretentive systems using rate-modifying polymers. Methodology: Nine ranitidine floating tablet formulations (F1-F9) were prepared using a multiple punch tablet compression machine with 9 mm round flat-faced punches, each containing 80 mg of ranitidine. Hydroxypropyl methylcellulose (HPMC K15M, HPMC K100M) and xanthan gum were used as rate-modifying polymers.

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Shalviri, Alireza, Avinash C. Sharma, Dipak Patel, and Amyn Sayani. "Low-Surfactant Microemulsions for Enhanced Topical Delivery of Poorly Soluble Drugs." Journal of Pharmacy & Pharmaceutical Sciences 14, no. 3 (2011): 315. http://dx.doi.org/10.18433/j38p4v.

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Purpose: To develop and characterize low-surfactant microemulsion (ME) gels to enhance topical delivery of poorly soluble drugs. Method: Five low surfactant ME formulations were manufactured following the construction of pseudo-ternary phase diagrams. The MEs were screened for their ability to dissolve a poorly soluble new chemical entity (Model Drug X). Various viscosity imparting agents like Carbopol 934, Colloidal Silica, HPMC K100M, Lubrajel NP, and Xanthan Gum were evaluated for the manufacture of these ME gels. Each ME gel was then further evaluated for physical stability, including asse

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Aziz, Mina Safa, and Methaq Hamad Sabar. "Development and optimization of an innovative raft-forming antiemetic gastro-retentive system." Pharmacia 72 (April 16, 2025): 1–14. https://doi.org/10.3897/pharmacia.72.e147836.

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Gastro-retentive drug delivery systems are vital for enhancing bioavailability and prolonging gastric residence time, especially for drugs with a short half-life like Ondansetron HCl. This study developed a raft-forming gastroretentive drug delivery system using a polyelectrolyte complex (PEC) of Chitosan and anionic polymers to improve stomach retention, regulate drug release, and enhance therapeutic efficacy. Various formulations were optimized based on polymer type, ratio, cross-linking agent concentration, and hydroxypropyl methylcellulose (HPMC K100M). The best formulation (F12: Chitosan:

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Ujjwal, Kukreti, Nainwal Nidhi, Ale Yogita, et al. "Release Kinetic of Sustained Release Matrix Tablet of Linezolid Containing Polymer Blend." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 03 (2024): 1479–84. http://dx.doi.org/10.25258/ijpqa.15.3.60.

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Tuberculosis (TB) is a bacterial infection mainly affecting the lungs. TB is a major health problem worldwide and the occurrence of extensively drug-resistant TB (XDR-TB) and multidrug-resistant TB (MDR-TB) offers considerable hurdles to effective treatment and disease management. The growth of treatment-resistant Mycobacterium TB strains has prompted the investigation of alternate therapeutic techniques, including the application of sustained drug delivery. Sustained-release drugs reduce the need for frequent dosing can extend the effects of linezolid by 8 to 12 hours, thus improving the pati

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Pasa, Gourishyam, Prasanta Kumar Choudhury, and Ghanshyam Panigrahi. "FORMULATION DESIGN AND OPTIMIZATION OF ORAL FLOATING MATRIX TABLETS OF CIPROFLOXACIN HCL BY USING HPMC AND XANTHAN GUM WITH EXPERIMENTAL DESIGN." Asian Journal of Pharmaceutical Research and Development 6, no. 6 (2018): 23–35. http://dx.doi.org/10.22270/ajprd.v6i6.430.

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The oral floating matrix tablets of Ciprofloxacin Hydrochloride were formulated by Experimental design by using HPMC K100M and Xanthan gum as the retardant polymers each with three different levels with an approach to increase gastric residence and thereby improve drug bioavailability. From FTIR results confirm the absence of chemical interaction between the drug with the excipients used in tablet formulations. Also, there was no shift in the endotherm of in the drug- excipients mixtures indicating compatibility of drug with all the excipients. All the tablets were prepared by effervescent app

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Kajal, A. Choursiya*1 Sachin M. Nikam2 Khanderao R. Jadhav3 Rishikesh S. Bachhav4. "Formulation Development And Evaluation Of Gastroretentive Floating Tablets Of Clopidogrel Bisulfate." International Journal in Pharmaceutical Sciences 2, no. 4 (2024): 1–25. https://doi.org/10.5281/zenodo.10903356.

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Gastroretentive floating tablets of clopidogrel bisulfate were prepared by direct compression method using HPMC K100M, Xanthan gum and mixture of other excipients. The drug content of tablets was found to be in between 100.08 0.92101.64 0.87 %. The in vitro dissolution studies of the prepared floating tablets were carried out on USP-I dissolution apparatus using Basket. It was observed that the formulations showed good linearity (r2 = 0.999) over the range of 0-30g/ml in 0.1N HCl. The IR spectra of drug and various polymers were recorded in combination with each other. The pH and solubility of

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Rahamathulla, Mohamed, Srinivasan Saisivam, Abdullah Alshetaili, et al. "Design and Evaluation of Losartan Potassium Effervescent Floating Matrix Tablets: In Vivo X-ray Imaging and Pharmacokinetic Studies in Albino Rabbits." Polymers 13, no. 20 (2021): 3476. http://dx.doi.org/10.3390/polym13203476.

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Losartan potassium (LP) is an angiotensin receptor blocker used to treat hypertension. At higher pH, it shows poor aqueous solubility, which leads to poor bioavailability and lowers its therapeutic effectiveness. The main aim of this research was to develop a direct compressed effervescent floating matrix tablet (EFMT) of LP using hydroxyl propyl methylcellulose 90SH 15,000 (HPMC-90SH 15,000), karaya gum (KG), and an effervescent agent, such as sodium bicarbonate (SB). Therefore, an EFMT has been developed to prolong the stomach residence time (GRT) of a drug to several hours and improve its b

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Srushti and Anand Kumar Yegnoor. "Design and optimization of ketoprofen floating tablets." Magna Scientia Advanced Biology and Pharmacy 11, no. 2 (2024): 080–89. http://dx.doi.org/10.30574/msabp.2024.11.2.0026.

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The objective of the present research work is design and optimize hydrodynamically balanced Ketoprofen (KF) floating tablets to enhance their gastric residence time because it has a narrow absorption window, poor bioavailability and short half-life. The Central Composite design is used to optimize the amount of Guar gum (X1) and HPMC K100M (X2) as two independent variables and study how they affect the two response such as in vitro Buoyancy lag time (Y1) and in vitro drug release (t50 Y2). Eleven trials were developed through the Central Composite design (CCD) to study all the optimal interact

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Mohammadi, Hafsa, Hemanath Kumar V, Roshan S, and Bhikshapathi D. V. R. N. "Development and Evaluation of Fast Disintegrating Tablets of Lornoxicam Solid Dispersions." International Journal of Pharmaceutical Sciences and Nanotechnology 12, no. 4 (2019): 4585–92. http://dx.doi.org/10.37285/ijpsn.2019.12.4.4.

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 Lornoxicam is a nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class. It belongs to BCS class II substance with low solubility and high permeability. The aim of current research is to formulate solid dispersion incorporated Fast disintegrating tablets of Lornoxicam to enhance the dissolution rate and aqueous solubility and to enable faster onset of action. Solid dispersions are prepared with polymers like Kolliwax GMS, Soluplus and HPMC in three different ratios 1:1:1, 1:2:1 and 1:3:1. Formulations were characterized for drug content studies, drug release studies, and drug-po

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Salih, Omar Saeb, and Roaa Abdalhameed Nief. "EFFECT OF NATURAL AND SYNTHETIC POLYMERS ON THE PROPERTIES OF CANDESARTAN CILEXETIL MATRIX TABLET PREPARED BY DRY GRANULATION." Asian Journal of Pharmaceutical and Clinical Research 9, no. 9 (2016): 161. http://dx.doi.org/10.22159/ajpcr.2016.v9s3.14719.

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ABSTRACTObjective: The objective of this study is to develop a controlled release matrix tablet of candesartan cilexetil to reduce the frequency of administration,enhance bioavailability and improve patient compliance; a once daily sustained release formulation of candesartan cilexetil is desirable.Methods: The prepared tablets from F1 to F24 were evaluated with different evaluation parameters like weight variation, drug content, friability,hardness, thickness and swelling ability. In vitro release for all formulas were studied depends on the type and amount of each polymer, i.e. (16 mg,32 mg

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Gorde, V. D., Punit R. Rachh, Someshwar Mankar, Saurin Amin, and Prasad L. Gorde. "Formulation and development of bilayer tablet containing irbesartan and metformin hydrochloride for diabetic hypertensive patients." Journal of Applied Pharmaceutical Research 12, no. 4 (2024): 66–74. http://dx.doi.org/10.69857/joapr.v12i4.589.

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Background: Hypertension is a common complication of type II diabetes. The present research work aimed to develop bilayer tablets that would manage type II diabetes patients with hypertension. The prepared bilayer tablet has an immediate-release layer of anti-hypertensive irbesartan and a sustained-release (SR) layer of anti-diabetic metformin hydrochloride. The purpose of these bilayer tablets was to increase patient compliance by converting two separate monotherapy to single combination therapy. Methodology: Several ratios of polymers, including HPMC K100M, EC, Eudragit, and Guar gum, were e

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Ravi, Krishna Velupula* Syeada Sumiara Shermeen Anil Goud Kandhula. "Formulation and Evaluation of Extended Release Tablets of Darifenacin Hydro bromide." Journal of Pharma Research 5, no. 12 (2016): 247–55. https://doi.org/10.5281/zenodo.4602931.

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ABSTRACT Darifenacin Hydrobromide is a Potent and selective antimuscarinic (M3) agent used in Symptomatic treatment of urge incontinence and/or increased urinary frequency as may occur in adult patients with overactive bladder syndrome. The objective of present study was to develop an effective Extended Release(ER) tablets of Darifenacin Hydrobromide to release the drug over an extended period of time that provide therapeutically effective plasma concentration for the treatment of urinary incontinence in humans with extended duration of action and less number of doses. Darifenacin Hydrobromide

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