Relevant bibliographies by topics / Karcinóm / carcinoma / Dissertations / Theses
To see the other types of publications on this topic, follow the link: Karcinóm / carcinoma.

Dissertations / Theses on the topic 'Karcinóm / carcinoma'

Author: Grafiati
Published: 7 June 2025
Last updated: 2 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Karcinóm / carcinoma.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Makštienė, Jurgita. "Skydliaukė karcinomų morfologinės charakteristikos savitumų ir jų diagnostikos kriterijų įvertinimas." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2005. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2005~D_20050829_120318-80670.

Full text
Abstract:
Summary of the Doctoral Dissertation Biomedical Science, Medicine (07 B) The doctoral dissertation has been prepared at Kaunas University of Medicine during the period of 2000-2004. Scientific Supervisor: Prof. Dr. Romualdas Gailys (Kaunas University of Medicine, Biomedical Sciences, Medicine – 07 B) The dissertation will be defended at the Medical Research Council of Kaunas University of Medicine. Chair: Prof. Habil. Dr. Dalia Pangonytė (Kaunas University of Medicine, Biomedical Sciences, Medicine – 07 B) Members: Prof. Habil. Dr. Vaiva Lesauskaitė (Kaunas University of Medicine, Biomedical
APA, Harvard, Vancouver, ISO, and other styles
2

Dimitrije, Jeremić. "Značaj određivanja koncentracije D vitamina u evaluaciji karcinoma prostate." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2015. https://www.cris.uns.ac.rs/record.jsf?recordId=100043&source=NDLTD&language=en.

Full text
Abstract:
Vitamin D ima antiproliferativno, proapoptotsko i prodiferencijaciono dejstvo. Dokazi o dejstvu na ćelije adenokarcinoma prostate su malobrojni i nekonzistentni. Cilj ispitivanja je određivanje stepena povezanosti između nivoa vitamina D, stadijuma adenokarcinoma prostate, prostata specifičnog antigena, Gleason grade i progresije oboljenja. Ispitivanje je prospektivno, sprovedeno na 120 ispitanika (90 pacijenata sa dijagnostikovanim karcinomom prostate i 30 kontrolnih, zdravih subjekata). Pacijenti sa dijagnostikovanim adenokarcinomom prostate podeljeni su prema stadijumu bolesti u dve grupe:
APA, Harvard, Vancouver, ISO, and other styles
3

Danica, Sazdanić-Velikić. "Prognostički faktori za preživljavanje kod gerijatrijskih bolesnika sa uznapredovalim stadijumom nemikrocelularnog karcinoma bronha." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2016. http://www.cris.uns.ac.rs/record.jsf?recordId=101147&source=NDLTD&language=en.

Full text
Abstract:
UVOD: Savremenim dijagnostičkim i terapijskim dostignućima, kao i unapređenjem preventivnih mera produžen je životni vek ljudi. Starenje stanovništva je fenomen koji zahvata ceo svet. Povećanje broja starijeg stanovništva je udruženo sa porastom broja obolelih od karcinoma u ovoj starosnoj grupi, jer je starenje samo po sebi riziko faktor za nastanak karcinoma. Incidenca pojave karcinoma naglo raste od 50-te godine života sa vrhom u 80-toj godini života. U osoba starijih od 65 godina se dijagnostikuje 58% svih karcinoma, a 30% u starijih od 70 godina. Godine starosti nisu kontrai
APA, Harvard, Vancouver, ISO, and other styles
4

Laurinavičienė, Aida. "The study of biological diversity of ductal breast carcinoma by molecular and digital pathology methods." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2012. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120426_160810-22763.

Full text
Abstract:
The 12th International St Gallen conference on breast cancer (2011) proposed patient categorization for systemic therapy, based on intrinsic breast cancer subtypes, defined by imunohistochemistry (IHC) test results. Since this classification is based on semi-quantitative expression of IHC biomarker expression, an issue of defining and applying cutoff values remains. Essential improvement in the IHC testing has become possible with digital image analysis tools enabling quantitative evaluation of the IHC data. This study explores data obtained by digital image analysis methods applied to evaluat
APA, Harvard, Vancouver, ISO, and other styles
5

Goran, Malenković. "Značaj hibridnog dijagnostičkog imidžinga u preoperativnoj evaluaciji karcinoma grlića materice." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2016. https://www.cris.uns.ac.rs/record.jsf?recordId=99749&source=NDLTD&language=en.

Full text
Abstract:
Uprkos postojanju dijagnostičkih procedura za ranu dijagnostiku, sprovođenju preventivnog skrining programa, te dugom preinvazivnom periodu u kojem je moguće izvršiti detekciju, karcinom grlića materice i dalje predstavlja jedan od vodećih zdravstvenih problema, imajući u vidu činjenicu da je uzrok obolevanja i umiranja velikog broja žena širom sveta. Oko 85% karcinoma grlića materice dijagnostikuje se u zemljama u razvoju, čineći čak 15% svih malignih tumora kod žena, dok u razvijenim zemljama ovaj procenat iznosi 3,6% novootkrivenih karcinoma. Prema podacima Registra za rak Voj
APA, Harvard, Vancouver, ISO, and other styles
6

Olivera, Ivanov. "Vrednost pozitronske emisione tomografije - kompjuterizovane tomografije u inicijalnom određivanju stadijuma kolorektalnog karcinoma." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2014. http://www.cris.uns.ac.rs/record.jsf?recordId=87641&source=NDLTD&language=en.

Full text
Abstract:
Kolorektalni karcinom je treća po redu maligna bolest po broju novoobolelih u svetskoj populaciji, posle karcinoma pluća i dojke. Petogodišnje preživljavanje od kolorektalnog karcinoma u SAD-u je 59-66%, u zemljama Zapadne Evrope oko 60% a u Autonomnoj Pokrajuni Vojvodini 27%. U razvijenim zemljama se sprovode skrining programi koji omogućavaju rano otkrivanje malignih bolesti, međutim, u Srbiji takav program ne postoji. Stoga je potrebno iznaći nove načine u inicijalnom menadžmentu obolelih od ove bolesti, koji će indirektno povećati njihovo preživljavanje. Jedan od načina je primena &
APA, Harvard, Vancouver, ISO, and other styles
7

Laurinavičienė, Aida. "Duktalinės krūties karcinomos biologinės įvairovės tyrimas molekulinės ir skaitmeninės patologijos metodais." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2012. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120426_161001-10542.

Full text
Abstract:
XII tarptautinėje St Gallen krūties vėžio konferencijoje (2011) Ekspertų komisijos priimta nauja pacientų klasifikacija sisteminei terapijai atlikti, paremta biologiniais krūties vėžio subtipais, kurie apibrėžiami imunohistocheminiu tyrimu (IHC). Tačiau ši nauja navikų klasifikacija iš esmės pagrįsta pusiau kiekybiniu biožymenų raiškos vertinimu, todėl išlieka aktuali ribinių verčių nustatymo problematika. Esminiai pokyčiai IHC tyrimų srityje galimi atsiradus skaitmeninio vaizdinimo technologijoms, leidžiančiomis IHC tyrimų rezultatus analizuoti kiekybiniais parametrais. Darbe naudojant skaitm
APA, Harvard, Vancouver, ISO, and other styles
8

Tatjana, Šarčev. "Prognostički faktori u lečenju medijastinoskopski dokazanog N2 i N3 stadijuma nemikrocelularnog karcinoma bronha." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2014. https://www.cris.uns.ac.rs/record.jsf?recordId=86753&source=NDLTD&language=en.

Full text
Abstract:
Karcinom bronha je danas u svetu najčešći uzrok smrti povezanih sa malignim bolestima. U XX veku je registrovan značajan porast kako incidence, tako i mortaliteta karcinoma bronha u većini zemalja. Medijana  preživljavanja u svim stadijumima bolesti se značajno poboljšala poslednjih godina XX veka, ali nedovoljno u odnosu na očekivano. U najvećem broju slučajeva, bolest se otkriva u uznapredovalom stadijumu, kada je radikalno hirurško lečenje kao optimalan vid lečenja nemoguće. Određivanje stadijuma bolesti (stejdžing) je najbitniji segment u evaluaciji svakog bolesni
APA, Harvard, Vancouver, ISO, and other styles
9

Nevena, Đukić. "Efikasnost lečenja bolesnika u IIIA stadijumu nemikrocelularnog karcinoma bronha operisanih nakon neoadjuvantne terapije." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2016. https://www.cris.uns.ac.rs/record.jsf?recordId=101677&source=NDLTD&language=en.

Full text
Abstract:
Karcinom bronha najčešći uzrok smrti među malignim bolesti u svetu. U XX veku je registrovan značajan porast kako incidence, tako i mortaliteta karcinoma bronha u većini zemalja. Medijana preživljavanja u svim stadijumima bolesti se značajno poboljšala poslednjih godina XX veka, ali nedovoljno u odnosu na očekivano. U najvećem broju slučajeva, bolest se otkriva u uznapredovalom stadijumu, kada je radikalno hirurško lečenje kao optimalan vid lečenja nemoguće. Neodjuvantna terapija kod bolesnika sa lokalno uznapredovalim karcinomom pluća i zahvaćenim N2 limfnim čvorovima jed
APA, Harvard, Vancouver, ISO, and other styles
10

Daliborka, Bursać. "Kardiotoksični efekat hemioterapije kod obolelih od nemikrocelularnog karcinoma bronha sa uznapredovalim stadijumom bolesti." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2015. http://www.cris.uns.ac.rs/record.jsf?recordId=91950&source=NDLTD&language=en.

Full text
Abstract:
Hemioterapija koja se koristi za lečenje karcinoma utiče i na kardiovaskularni sistem. Ciljevi  istraživanja  su: u tvrditi uticaj kardiotoksičnosti  na  reživljavanje  bolesnika  sa uznapredovalim stadijumom NSCLC; utvrditi učestalost pojave kardiotoksičnosti kod bolesnika koji su lečeni hemioterapijom prve linije (gemcitabin/cisplatin i paclitaxel/carboplatin) sa i bez prethodnih kardiovaskularnih oboljenja i utvrditi učestalost pojave kardiotoksičnosti u toku primene protokola docetaxel/cisplatin kao hemioterapije druge linije, u odnosu na primenu protokola gem
APA, Harvard, Vancouver, ISO, and other styles
11

Golub, Samardžija. "Patohistološka procena tumorske regresije kod nemikrocelularnih karcinoma pluća posle neoadjuvantne terapije." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2016. http://www.cris.uns.ac.rs/record.jsf?recordId=101318&source=NDLTD&language=en.

Full text
Abstract:
Karcinomi pluća su najčešći uzrok oboljevanja i umiranja od malignih tumora u Svetu. Neodjuvantna terapija kod bolesnika sa lokalno uznapredovalim (IIIA-IIIB) karcinomom pluća i zahvaćenim N2 limfnim čvorovima jedan je od modusa multimodalnog lečenja bolesnika sa nemikrocelularnim karcinomima pluća (NSCLC) u cilju poboljšanja ishoda njihovog lečenja. Ovakav pristup podrazumeva prevođenje bolesnika iz višeg u niži stadijum bolesti - „downstaging”. Do danas nije utvrđena povezanost između pojedinih obrazaca tumorskog odgovora i vrste terapije. S obzirom na značaj
APA, Harvard, Vancouver, ISO, and other styles
12

Darijo, Bokan. "Uticaj demografskih faktora i karakteristika tumora na preživljavanje obolelih od karcinoma bronha u Vojvodini." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2020. https://www.cris.uns.ac.rs/record.jsf?recordId=114455&source=NDLTD&language=en.

Full text
Abstract:
Širom sveta, karcinom bronha je i dalje vodeći po incidenci i mortalitetu, sa 2,1 milion novih slučajeva i predviđenih 1,8 smrtnih ishoda u 2018. godini. Karcinom bronha predstavlja skoro petinu (18,4%) svih smrtnih ishoda od karcinoma. Istraživanje je sprovedeno kao retrospektivna studija za period 2010-2016 godine. Svi podaci potrebni za sprovođenje ovog istraživanja direktno su prikupljeni iz zdravstvenog informacionog sistema i registra za karcinom bronha Instituta za plućne bolesti Vojvodine (IPBV), koji je referentna ustanova za pacijente sa karcinomom bronha za celu Autonomnu Pok
APA, Harvard, Vancouver, ISO, and other styles
13

Miroslav, Latinović. "Konvencionalni, konformalni i fuzionisani modalitet planiranja radioterapije planocelularnog karcinoma glave i vrata." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2018. https://www.cris.uns.ac.rs/record.jsf?recordId=107035&source=NDLTD&language=en.

Full text
Abstract:
Uvod: Učestalost neželjenih efekata uzrokovanih zračenjem kod pacijenata sa karcinomom glave i vrata zavisi od tehnike planiranja, sprovođenja radioterapije kao i primarne lokalizacije tumora. Cilj: Osnovna uloga našeg istraživanja je da se utvrdi učestalost neželjenih efekata tokom zračne terapije kod pacijenata sa tumorom glave i vrata tretiranih 2D konvencionalnom radioterapijom, 3D konformalnom radioterapijom planiranoj samo na osnovu CT-a nasuprot 3D konformalnoj terapiji planiranoj na osnovu fuzije kompjuterizovane tomografije sa magnetno rezontnim imidžingom (CT-MRI). Metode: Pro
APA, Harvard, Vancouver, ISO, and other styles
14

Ivana, Mijatov. "Uticaj dubine invazije oralnog planocelularnog karcinoma na pojavu metastaza u limfnim čvorovima vrata." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2019. https://www.cris.uns.ac.rs/record.jsf?recordId=110690&source=NDLTD&language=en.

Full text
Abstract:
Oralni karcinom je po učestalosti šesta najčešća maligna bolest u svetu čija incidenca varira u različitim geografskim područjima. Predstavlja 5% svih novootkrivenih malignih tumora godišnje i čini 14% svih malignih tumora glave i vrata. Pod oralnim karcinom podrazumevamo planocelularni karcinom obzirom na činjenicu da on čini preko 90% malignih tumora oralne lokalizacije, dok se u manjem procentu javljaju drugi tumori (maligni tumori malih pljuvačnih žlezda, limfomi, mezenhimni tumori). Oralni karcinom podrazumeva karcinome koji se javljaju u sledećim anatomskim regijama:
APA, Harvard, Vancouver, ISO, and other styles
15

Nada, Vasić. "Primena jednodimenzionalnog i volumetrijskog merenja u evaluaciji terapijskog odgovora karcinoma pluća višeslojnom kompjuterizovanom tomografijom." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2019. https://www.cris.uns.ac.rs/record.jsf?recordId=110621&source=NDLTD&language=en.

Full text
Abstract:
Karcinom pluća predstavlja vodeći uzrok smrtnosti među svim malignim obolenjima, a uprkos dostignućima u dijagnostici i terapiji u poslednjih 30 godina nije došlo do bitnog poboljšanja izuzetno niske ukupne stope petogodišnjeg preživljavanja kod ovih pacijenata. U momentu otkrivanja bolesti preko trećine svih novootkrivenih slučajeva nalazi se u IV stadijumu bolesti. Precizno i adekvatno praćenje odgovora tumora na terapijski tretman kod obolelih od karcinoma pluća u IV stadijumu kao i što ranije utvrđivanje progresije bolesti, odnosno neefikasnosti terapijskog tret
APA, Harvard, Vancouver, ISO, and other styles
16

Liutkevičius, Vykintas. "Matrikso metaloproteinazių raiškos ir jų genų polimorfizmo charakteristika nepiktybinių gerklų darinių, ikivėžinių būklių bei gerklų vėžio atvejais." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20110922_122351-23836.

Full text
Abstract:
Darbo uždaviniai buvo: Nustatyti gerklų audinio MMP-2 ir MMP-9 raiškos pokyčius kai yra nepiktybiniai gerklų dariniai (balso klosčių polipai), ikivėžinė gerklų patologija (atsinaujinanti gerklų papilomatozė ir lėtinis hiperplazinis laringitas su keratoze) bei gerklų plokščių ląstelių karcinoma ir įvertinti šių pokyčių diagnozinę vertę. Įvertinti gerklų audinio MMP-2 ir MMP-9 raiškos pokyčių sąsajas su klinikiniais ir morfologiniais nepiktybinių gerklų darinių (balso klosčių polipai), ikivėžinės gerklų patologijos (atsinaujinanti gerklų papilomatozė ir lėtinis hiperplazinis laringitas su kerato
APA, Harvard, Vancouver, ISO, and other styles
17

Nenad, Šolajić. "Prognostički značaj gustine tumorskih pupoljaka i citoplazmatskih pseudofragmenata u tumorskom tkivu karcinoma kolona kod bolesnika u stadijumu II." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2016. http://www.cris.uns.ac.rs/record.jsf?recordId=101547&source=NDLTD&language=en.

Full text
Abstract:
UVOD: Karcinom kolona (KK) je velik javnozdravstveni problem usled visoke incidence i stope mortaliteta. Kod KK je stadijum bolesti najvažniji pojedinačni nezavisni faktor prognoze. U prisustvu nepovoljnih prognostičkih parametara, u koje spadaju visok histološki gradus, ileus, limfo-vaskularna i perineuralna invazija, nakon potencijalno kurativne operacije se kod pacijenata u stadijumu II indikuje primena adjuvantne hemioterapije koja ima pozitivan uticaj na ukupno preživljavanje i na produženje perioda bez bolesti. Međutim, relapsi bolesti nastaju kod nekih bolesnika bez negativnih pr
APA, Harvard, Vancouver, ISO, and other styles
18

Strioga, Marius. "Expression of biomarkers, representing immunosuppressive, cytotoxic or immunomodulating properties of CD8h T lymphocytes in the peripheral blood of patients with immunogenic cancer forms." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100702_105111-42651.

Full text
Abstract:
The aim of the study was to evaluate the expression of immunosuppressive (FOXP3, NKG2A), and cytotoxic (perforin) or cytotoxic / immunomodulating (IFNγ) T-cell properties representing biomarkers in the peripheral blood CD8h T-cell population of patients with advanced renal cell carcinoma (RCC) or high risk cutaneous melanoma and healthy controls by multicolour flow cytometry. Determination of the percentage of functionally competing T-cell subsets (especially immunosuppressive) in the CD8hCD57+ T-cell subpopulation in future may serve as one of parameters enabling to assess the overall status
APA, Harvard, Vancouver, ISO, and other styles
19

Strioga, Marius. "Imunosupresines, citotoksines bei imunomoduliuojančias savybes atspindinčių žymenų raiška imunogeniškomis vėžio formomis sergančių pacientų periferinio kraujo CD8h T limfocitų populiacijoje." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100702_105125-92547.

Full text
Abstract:
Darbo tikslas buvo įvertinti imunosupresines (FOXP3, NKG2A), citotoksines (perforin) bei citotoksines / imunomoduliuojančias (IFNγ) savybes atspindinčių žymenų raiškos skirtumus išplitusiu inkstų vėžiu ar didelės rizikos odos melanoma sergančių pacientų periferinio kraujo CD8h T limfocitų populiacijoje, lyginant su kontroline grupe. Skirtingas T limfocitų savybes atspindinčių žymenų raiška buvo tiriama tėkmės citometrijos būdu. Nustatyta, kad inkstų vėžiu ar odos melanoma sergančių pacientų periferiniame kraujyje Įvairių subpopuliacijų (ypač imunosupresinės) nuošimčio nustatymas CD8hCD57+ T li
APA, Harvard, Vancouver, ISO, and other styles
20

Mirjana, Udicki. "Анализа односа степена ухрањености са маркерима инфламације и оксидативног стреса у масном ткиву дојке код жена у репродуктивном периоду оболелих од карцинома дојке". Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2019. https://www.cris.uns.ac.rs/record.jsf?recordId=108865&source=NDLTD&language=en.

Full text
Abstract:
Познато је да гојазност представља фактор ризика за развој карцинома дојке након менопаузе, док су подаци који се односе на репродуктивни периоду опречни. Познато је да је масно ткиво гојазних подложно хроничној инфламацији ниског степена и развоју оксидативног стреса. Ове промене су знатно боље испитане у висцералном масном ткиву у контексту развоја кардиометаболичких компликација, док је њихова улога у карциногенези мање позната. Циљ истраживања била је анализа масе и дистрибуције масног ткива пременопаузалних жена оболелих од карцинома дојке, као и показатеља инфламаторних промена и оксидат
APA, Harvard, Vancouver, ISO, and other styles
21

Akramienė, Dalia. "Assessment of the modulation of photodynamic effect by β-glucan and characteristics of anti-CD7 monoclonal antibody during tumor process". Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20110309_111259-65000.

Full text
Abstract:
Activation of the immune system during photodynamic therapy (PDT) and improvement of the effector functions of mAbs - these are the ways to use and enhance the potential of the immune system to fight cancer. Tumor cells lack β-glucan as a surface compo¬nent and can‘t trigger complement receptor 3-dependent cellular cytoto¬xicity and initiate tumor-killing activity during PDT. So, it gave rise to the hypothesis that β-glucan in combination with PDT will produce more effective killing of by iC3b fragment opsonized tumor cells. The human Fc portion is essential for the recruiting of human effecto
APA, Harvard, Vancouver, ISO, and other styles
22

Branislava, Gajić. "Корелација клинички и патохистолошки одређене латералне маргине код базоцелуларног карцинома коже". Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2016. http://www.cris.uns.ac.rs/record.jsf?recordId=100846&source=NDLTD&language=en.

Full text
Abstract:
Увод. Базоцелуларни карцином коже (БЦК) је спорорастући малигни епидермални тумор. овај најчешћи тумор у људи иако врло ниског метастатског потенцијала може бити високо инвазиван и значајно допринети морбидитету, угрозити функцију и естетику регије, па и сам живот. Лечење БЦК има за циљ: уклањање тумора, очување здравог ткива и функције, оптимални козметски резултат. Најчешћи вид лечења БЦК је једноставна хируршка ексцизија. Према важећим препорукама БЦК се ексцидирају са заштитним маргинама од 5-10 mm. Одређени броју студија показују директно или индиректно да је клинички одређена маргина врл
APA, Harvard, Vancouver, ISO, and other styles
23

Čaja, Fabián. "Mutace v genu MLH1 a MSI status jako molekulární charakteristiky sporadického kolorektálního karcinomu." Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-310521.

Full text
Abstract:
Colorectal carcinoma (CRC) is one of the most prevalent malignancies in the Czech Republic. In general, there are two molecular pathways leading to CRC: one is characterized by chromosomal instability, the other by the deficiency in DNA mismatch repair (MMR) genes. MutL homologue 1 (MLH1) gene, a member of the MMR gene-family, represents a key component of the MMR system, responsible for recognition of nucleotide mismatches occurring during DNA replication, and for the recruitment of repair proteins to correct the replication errors. According to literature, somatic mutations in MMR genes, and
APA, Harvard, Vancouver, ISO, and other styles
24

Semaneková, Viera. "Screening kandidátních genů u karcinomu prostaty a močového měchýře." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-322124.

Full text
Abstract:
Prostate carcinoma is considered to be one of the main medical problem in male population. Prostate carcinoma is the most frequently diagnosed malignancy in men and the death rate has the second position within all diagnosed malignancies in Czech Republic (ÚZIS). There is only one reliable diagnostic tool: PSA (prostate specific antigen). Level of PSA is often elevated in men with prostate carcinoma. This diploma thesis is focused on study of changes in gene expression in prostate carcinoma. Three candidate genes were analyzed: VCL (vinculin), SHB (Src homology 2 binding protein) and OCT3 (org
APA, Harvard, Vancouver, ISO, and other styles
25

Wohl, Pavel. "Kolorektální karcinom - od patogeneze ke screeningu. Kolorektální karcinogeneze u ulcerózní kolitidy s primární sklerózující cholangitidou a problematika screeningu kolorektálního karcinomu." Doctoral thesis, 2018. http://www.nusl.cz/ntk/nusl-403350.

Full text
Abstract:
Colorectal carcinoma (CRC) ranks high in mortality and morbidity in most developed countries. Following theses focus on specific aspects of colorectal carcinoma pathogenesis including the issue of screening. The goal of the first study was assessment of expression of epithelial markers of colorectal carcinogenesis p53, COX-2, bcl-2. The study included patients with active ulcerative colitis (UCA), ulcerative colitis in remission (UCR), primary sclerosing cholangitis with ulcerative colitis (PSC-UC) (PSC), patients after liver transplantation for PSC (OLT) and a control group (N). We found sign
APA, Harvard, Vancouver, ISO, and other styles
26

Lipská, Ludmila. "Colorectal carcinoma and markers of biological activity." Doctoral thesis, 2006. http://www.nusl.cz/ntk/nusl-268921.

Full text
APA, Harvard, Vancouver, ISO, and other styles
27

Pešta, Martin. "Sledování biologické aktivity kolorektálního karcinomu metodou real-time PCR." Doctoral thesis, 2006. http://www.nusl.cz/ntk/nusl-270776.

Full text
Abstract:
The author in his doctoral thesis, proposed primers and conditions optimized design Quantitative PCR for determining the gene expression of MMP-7, TIMP-1, MMP-2 and TIMP- second Revealed the presence of gene expression of GAPDH TIMP-1 and TIMP-2 in cancer line HT-29 SW480 and SW620. Noted the high level expression of MMP-7 in line HT-29th Expression of the 2-3 orders of magnitude higher than the lines SW480 and SW620. MRNA expression of MMP-2 in line HT-29 noticed. MRNA expression of MMP-2 by the detected lines SW480 and SW620. He found that determining absolute and relative expression in tumo
APA, Harvard, Vancouver, ISO, and other styles
28

Šteiner, Petr. "Korelace molekulárně-genetických a morfologických znaků vzácných nádorů slinných žláz." Doctoral thesis, 2018. http://www.nusl.cz/ntk/nusl-384530.

Full text
Abstract:
Thesis deals with relationship between histomorphological and molecular-genetic findings of selected salivary gland tumors. Author, as a molecular-cytogeneticist mainly focused on detection of tumor-specific translocations of the salivary gland tumors which can serve as differential diagnostic markers. The thesis is composed as a commented files of authors own publications, and it is divided into four parts. First part deepens the knowledge of salivary adenoid cystic carcinoma. It was proved, that t(6;9)(q22-23;p23-24) resulting in fusion of transcription factors MYB-NFIB, or more rarely t(8;9
APA, Harvard, Vancouver, ISO, and other styles
29

Belšánová, Barbora. "Optimalizace metodiky pro stanovení volné nádorové DNA v plazmě a její klinické využití u pacientů s karcinomy kolorekta, plic a slinivky břišní." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-368058.

Full text
Abstract:
In current days, examination of circulating tumor DNA (ctDNA) finds new use across different cancers. It is directed at tumor-derived short fragments of DNA present in peripheral blood of patiens (mainly in advanced stages). Due to its minimal invasivity, almost 100 % specificity and relatively high sensitivity in stage IV patients, this approch found its main potential clinical utility especially in early detection of disease relapse or progression after tumor resection (i.e. post-operative follow-up), prediction and monitoring of therapy response and estimation of prognosis. As a result of m
APA, Harvard, Vancouver, ISO, and other styles
30

Presl, Jiří. "Biomarkery epiteliálních nádorů ovaria a endometria." Doctoral thesis, 2013. http://www.nusl.cz/ntk/nusl-326149.

Full text
Abstract:
Structured abstract Study objectives: Ovarian carcinoma 1/ comparison of sensitivities among monitored markers CA 125, HE4, CA 19-9, CEA, TK, TPS, MonoTotal 2/ comparison of false positivity of markers CA 125 and HE4 3/ use of CA 125, HE4 and ROMA index in the diagnostics of ovarian carcinoma 4/ use of CA 125 and HE4 in the follow-up of ovarian cancer Endometrial carcinoma 1/ feasibility of use of biomarkers CA125 and HE4 in patients with endometrial cancer in pre- operative management Study design: Retrospective data analysis Settings: Department of Obstetrics and Gynecology, Medical Faculty
APA, Harvard, Vancouver, ISO, and other styles
31

Šteiner, Petr. "Molekulárně genetická charakterizace vzácných nádorů urogenitálního traktu." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-312692.

Full text
Abstract:
The aim of this study was molecular characterization of four types of renal tumours (papillary renal cell carcinoma [PRCC], tubulocystic renal carcinoma [TCRC], pseudorossette forming renal carcinoma [PRRC] and unclassified renal carcinomas [URC]) and two types of rare tumours of the testes (Adult type of granulosa cell tumours [ATGCTs] and Incompletely differentiated sex cord stromal tumours [ISCSTs]). In case of TCRC the activity of signalling pathways involved in angiogenesis was studied. The aim was to determine the suitability of antiangiogenic agents for treatment of TCRC. Next, the meth
APA, Harvard, Vancouver, ISO, and other styles
32

Chmelařová, Žaneta. "Analýza genetických faktorů vzniku karcinomu prsu." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-380736.

Full text
Abstract:
The thesis The analysis of genetic factors of breast cancer by NGS deals with the current serious problematics of breast cancer from the perspective of genetic predisposition. Breast cancer is one of the most common tumors in women. Every year more than 7000 women are diagnosed with this disease and the mortality rate in the Czech Republic is nearly 2000 cases. Of the total number of patients diagnosed with breast cancer, approximately ten percent of patients have congenital mutations in one of the predisposing genes that cause a significantly increased risk of developing a cancer. More than h
APA, Harvard, Vancouver, ISO, and other styles
33

Krhutová, Magdaléna. "Změny exprese dlouhých nekódujících RNA u hepatocelulárního karcinomu." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-411920.

Full text
Abstract:
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Bc. Magdaléna Krhutová Supervisor: prof. PharmDr. Petr Pávek, Ph.D. Title of diploma thesis: The changes in expression of long non-coding RNAs in hepatocellular carcinoma Hepatocellular carcinoma (HCC) is one of the highly prevalent cancers globally. A number of new cases of HCC and deaths rises every year. Molecular mechanisms of HCC are being intensively studied, yet they are not still fully understood. In addition to genetic alterations, epigenetics also plays an important role in HCC p
APA, Harvard, Vancouver, ISO, and other styles
34

Cerovská, Ela. "Biomarkery prognózy a účinnosti terapie ovariálního karcinomu." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-343055.

Full text
Abstract:
Ovarian carcinoma is a serious illness with the highest mortality rate among all female cancers. No suitable methods for early diagnosis, precise determination of prognosis or prediction of therapy efficacy are currently available, which leads to diagnosis in advanced stages of disease and therapy efficacy limitation. Consequently, the development of chemoresistance to conventional drugs and frequent relapse of the disease pose a fundamental complication too. The main goal of the current study was identification of new putative prognostic and therapeutic biomarkers, whose introduction into cli
APA, Harvard, Vancouver, ISO, and other styles
35

Burócziová, Monika. "Molekulární charakteristika mismatch reparační dráhy u ovariálního karcinomu." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-345028.

Full text
Abstract:
In humans, multi enzymatic processes are involved in maintaining DNA stability and cellular homeostasis. Cells undergo several episodes to survive and protect itself in daily basis. Accumulation of DNA errors and breaks are repaired by dynamic machinery, such as mismatch repair (MMR), replication-related process. In presented diploma thesis, we report the studied MMR pathway and its involvement in malignancy of epithelial ovarian cancer (EOC). Our working hypothesis postulated that core genes of MMR, such as MLH1 and MSH2 are down-regulated in malignant cells. Cells therefore become incapable
APA, Harvard, Vancouver, ISO, and other styles
36

Kulda, Vlastimil. "Regulace genové exprese v nádorové tkáni." Doctoral thesis, 2018. http://www.nusl.cz/ntk/nusl-388199.

Full text
Abstract:
Deregulation of gene expression caused by genetic or epigenetic changes plays an important role in pathogenesis of cancer. The thesis is a commented collection of ten publications dealing with the molecular biology of tumours. The author has significantly contributed to all of them. All the articles contained in the thesis are linked to the topic of assessment of molecules involved in gene expression regulation (microRNAs) or DNA alterations that affect gene expression (promoter methylation, presence of a fusion gene). MicroRNAs are short single-stranded RNA molecules involved in posttranscrip
APA, Harvard, Vancouver, ISO, and other styles
37

Partlová, Simona. "Imunoterapie karcinomu ovaria dendritickými buňkami." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-295861.

Full text
Abstract:
V ANGLICKÉM JAZYCE Immunotherapy of ovarian carcinoma with dendritic cells Anticancer immunotherapy is a therapeutical strategy aimed at elicitation and maintenance of immune responses against cancer cells. In this study we have focused on immunotherapy of ovarian cancer, because it is one of the most common gynaecological tumors with poor prognosis and high mortality. Our immunotherapy protocol involves preparing dendritic cells (DC) from monocytes isolated from patient's peripheral blood, which are subsequently pulsed with irradiated cells of established ovarian cancer cell line. These immat
APA, Harvard, Vancouver, ISO, and other styles
38

Ožanová, Michaela. "Skrytá malnutrice u pacientek v pokročilých stádiích ovariálního karcinomu." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-383349.

Full text
Abstract:
This diploma thesis deals with the topic of hidden malnutrition in patients with advanced stage of ovarian carcinoma. Tumor diseases are often accompanied by malnutrition. In the case of ovarian cancer, malnutrition may be hidden, primarily due to ascites, which can distort body weight. Out of the patients included in this study 32 % had ascites. The basic nutritional status test in hospitals is the nutritional screening performed on each hospitalized patient to detect the risk of malnutrition. Other methods such as anthropometric measurements, laboratory values, bioimpedance analysis, or less
APA, Harvard, Vancouver, ISO, and other styles
39

Veškrňová, Veronika. "Diagnostické a prognostické markery v éře cílené léčby CRC." Doctoral thesis, 2021. http://www.nusl.cz/ntk/nusl-438791.

Full text
Abstract:
Introduction: Colorectal cancer (CRC) is the most common malignant tumor in both sexes in the Czech Republic. Prognostic factors in CRC can be classified as clinical (stage at the time of diagnosis, histological type of tumor), genetic (RAS, BRAF), immunological (Immunoscore)and biochemical (CEA, CA 19-9, miRNA). MicroRNAs (miRNAs) regulate the expression of oncogenes and tumor suppressors. The regulatory function of miRNAs is influenced by single nucleotide polymorphisms (SNPs) of target miRNA binding sites (miRSNPs). Aims: To evaluate the currently available prognostic factors for CRC patien
APA, Harvard, Vancouver, ISO, and other styles
40

Krupicová, Daniela. "Exprese kandidátních genů karcinomu prostaty." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-323648.

Full text
Abstract:
4 Abstract Prostate cancer is one of the major medical problems within the male population in the Czech Republic and in the world. It is on second place among cancer illnesses with respect to mortality in czech male population. Its incidence strongly increases with age. Prostate cells have a unique ability to accumulate zinc in high concentrations compared to other tissues of human body. It is necessary for the proper physiological function of the prostate. There was detected loss of this accumulation ability in prostate cancer cells, which seems to be a condition to carcinogenesis in prostate
APA, Harvard, Vancouver, ISO, and other styles
41

Mohelníková, Duchoňová Beatrice. "Sledování genetických faktorů ovlivňujících riziko vzniku a průběh karcinomů kolorekta a pankreatu." Doctoral thesis, 2012. http://www.nusl.cz/ntk/nusl-311805.

Full text
Abstract:
Introduction: The aim of this study was to evaluate the role of genetic and lifestyle factors in the risk of onset and progression of colorectal and pancreatic cancer. The first part deals with the etiological factors and the importance of polymorphisms in biotransformation enzymes and genetic alterations in the gene CHEK2 in the origin of these malignancies. In the second part, the ABC transporter genes were analyzed as potential prognostic and predictive markers of a treatment's outcome. Materials and methods: The polymorphisms and other genetic alterations were detected using real-time PCR,
APA, Harvard, Vancouver, ISO, and other styles
42

Václavíková, Eliška. "Genetické příčiny medulárního karcinomu štítné žlázy a Hirschsprungovy choroby." Doctoral thesis, 2015. http://www.nusl.cz/ntk/nusl-350970.

Full text
Abstract:
Genetic causes of medullary thyroid carcinoma and Hirschsprung's disease Abstract Medullary thyroid carcinoma (MTC) and Hirschsprung's disease (HSCR) are classified as simple neurocristopathies, i.e. diseases linked to neural crest-derived cells. MTC is derived from parafollicular cells of the thyroid and HSCR is characterized by absence of enteric ganglia in the gastrointestinal tract. The RET proto-oncogene is only expressed in neural crest-derived cells, including parafollicular cells and enteric neurons. The RET encodes a transmembrane tyrosinekinase receptor that plays an important role d
APA, Harvard, Vancouver, ISO, and other styles
43

Martínek, Petr. "Molekulárně genetické profilování nádorů urogenitálního traktu." Doctoral thesis, 2015. http://www.nusl.cz/ntk/nusl-334643.

Full text
Abstract:
The Ph.D. thesis is a collection of eleven commented articles on the topic of molecular-genetic profiling of urogenital tract tumors published in impact factor journals. In the introduction the origin and development of classification units is described including a brief overview of recent genetic profiles of selected types of renal carcinomas. Reviewed are major signaling pathways exploited in targeted therapy as well as the function of the corresponding drugs. Directions in which the research of new biomarkers is aimed are mentioned and the introduction ends with a short list of molecular ge
APA, Harvard, Vancouver, ISO, and other styles
44

Judasová, Kristýna. "Studium populačně specifických alterací v genech predisponujících ke vzniku karcinomu prsu v ČR." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-348329.

Full text
Abstract:
Breast cancer is the most frequent malignant disease in the female population worldvide. About 10 % of all cases are of hereditary origin. The inactivation of tumor suppressor gene BRCA1 is the main genetic predisposing factor in breast cancer in the Czech Republic. Primarily, BRCA1 participates in DNA double strand break repair. Depending on cell cycle phase, the damage is repaired by homologous recombination or non-homologous end joining. Alternative splicing variants of BRCA1 are frequently detected during the genetic screening of high risk patients. The clinical significance of these varia
APA, Harvard, Vancouver, ISO, and other styles
45

HORNÍKOVÁ, Kateřina. "Primární a sekundární prevence kolorektálního karcinomu u osob nad 50 let." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-200634.

Full text
Abstract:
As the title reveals, the thesis deals with primary and secondary prevention of colorectal carcinoma among people over 50 years of age. Colorectal carcinoma, i.e. tumour disease of the colon or rectum, is a serious disease with increasing incidence. The Czech Republic has one of the highest incidence rates of this disease and is at the forefront of global statistics. Every year, about 8000 people are diagnosed with colorectal carcinoma in our country and about 4000 patients die of this disease every year. Almost four people out of ten have vicarious experience with colorectal carcinoma, claimi
APA, Harvard, Vancouver, ISO, and other styles
46

Lukešová, Eva. "Imunofenotypizace pacientů s HPV-asociovanými a neasociovanými karcinomy hlavy a krku." Doctoral thesis, 2014. http://www.nusl.cz/ntk/nusl-335638.

Full text
Abstract:
Head and neck squamous cell carcinomas (HNSCC) remain a significant cause of morbidity worldwide, with approximately 550,000 new cases diagnosed each year. The main etiological factors include smoking and alcohol consumption. The incidence of non-oropharyngeal HNSCC is gradually decreasing while the incidence of squamous cell oropharyngeal carcinoma (OPSCC) is still on the rise. This increasing incidence can be most likely attributed to an increasing prevalence of human papillomavirus (HPV) infection. From the clinical point of view the most significant fact is that patients with HPV positive
APA, Harvard, Vancouver, ISO, and other styles
47

Ksandrová, Marie. "Sledování parametrů imunitní odpovědi u pacientek s karcinomem ovária léčených experimentální aktivní buněčnou imunoterapií DCVac/OvCa ve fázi II klinického hodnocení." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-355914.

Full text
Abstract:
The immunotherapeutic drug DCVAC/OvCa is being tested in the treatment of ovarian cancer patients within the SOV02 clinical trial (Eudra CT number: 2013-001323-38). Ovarian cancer belongs to gynaecological malignancies with the highest mortality rate. Around 60% of patients are diagnosed at advanced stages. Despite the initial successful treatment, relapses occur in most cases, and the disease often becomes resistant to chemotherapy. Effective therapy for relapsed or metastatic patients is still missing. The solution could be immunotherapeutic treatment. DCVAC is an active cellular immunothera
APA, Harvard, Vancouver, ISO, and other styles
48

Kastner, Jan. "Studium časné kancerogeneze u spinoceluárního karcinomu hlavy a krku." Doctoral thesis, 2020. http://www.nusl.cz/ntk/nusl-410158.

Full text
Abstract:
Squamous cell carcinoma is the most frequent malignant tumour of head and neck. Prognostic and predictive information as an individual imprint of molecular-genetic analysis of HNSCC will help to determine the best indivicual treatment. And in case of surgical appraoch the optimal resection with adequate quality of life and long-term survival. Study of early cancerogenesis in our project is based on knowledge, that histological normal mucosa next to tumor shows preneoplastic molecular alterations. Molecular genetic changes in a histological normal mucosa harbouring a tumor may play a principal
APA, Harvard, Vancouver, ISO, and other styles
49

Davidová, Eliška. "Úloha transkripčního faktoru Snail v mechanismu rozvoje radiorezistence u nádorových linií karcinomu prostaty." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-343809.

Full text
Abstract:
The frequent cause of failure of prostate carcinoma radiotherapy and chemotherapy is the emergence of resistance and a progress into the essentially incurable metastatic form of disease. Although the mechanisms of the radioresistance and chemoresistance are still not well understood, recent studies indicate that transcription factor Snail, a key mediator of the epithelial-mesenchymal transition and subsequent metastasis formation, plays a critical role in the development of the chemoresistance and radioresistance in the tumor cells. As the activation of the optimal DNA damage response pathway
APA, Harvard, Vancouver, ISO, and other styles
50

Ryznarová, Zuzana. "Možnosti využití pokročilých MR technik při zobrazování malé pánve." Doctoral thesis, 2019. http://www.nusl.cz/ntk/nusl-408812.

Full text
Abstract:
(AJ) The three aims of the work were as follows: 1. Comparison of prostate magnetic resonance (MR) examination results from 1.5 T and 3 T scanners in patients with prostate carcinoma (PCa). MR findings of 103 patients (ages 44-72 years) were compared with histopathological results after radical prostatectomy. The work was focused on the accuracy of predicting local cancer staging and determining prostate tumour location. Patients were divided into three groups (A, B and C) based on the type of MR scanner and protocol used. Patient groups A and B were examined in 1.5T and 3T MR scanners equippe
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the bibliographies on the topic 'Karcinóm / carcinoma' for other source types:
Journal articles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography