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Journal articles on the topic 'Karnofsky performance scale (KPS)'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Parala-Metz, Armida, Wael Lasheen, Daniel Ernest Haggstrom, Raghava Reddy Induru, Anthony James Caprio, and Declan Walsh. "Is Karnofsky performance scale a proxy measure of frailty phenotype in older adults with cancer?" Journal of Clinical Oncology 41, no. 16_suppl (2023): e24035-e24035. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e24035.

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e24035 Background: The use of performance status (PS) assessments in patients with cancer is a common practice to determine their suitability for treatment, clinical trial enrollment, and prognosis. The Karnofsky Performance Scale (KPS) and Eastern Cooperative Oncology Group Performance Status (ECOG PS) score are widely used clinical instruments for this purpose. However, these tools are subjective and unidimensional, with potential for bias, and were validated in younger patients. KPS has demonstrated greater specificity than ECOG in evaluating PS. Frailty, a dynamic medical syndrome characte

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Malueka, Rusdy, Ery Dwianingsih, Maria Alethea, et al. "BIOM-29. ASSOCIATION OF PLASMA microRNA-21 EXPRESSION WITH KARNOFSKY PERFORMANCE SCALE SCORES IN GLIOMA PATIENTS." Neuro-Oncology 23, Supplement_6 (2021): vi17. http://dx.doi.org/10.1093/neuonc/noab196.060.

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Abstract Gliomas are one of the most common primary brain tumors. MicroRNA-21 (miRNA-21) has been shown in previous studies to be associated with prognosis in glioma patients. However, similar studies in the Asian population, particularly in Indonesia, are very limited. This study aimed to find the association of plasma miRNA-21 expression with functional status measured by Karnofsky Performance Scale (KPS) in Indonesian glioma patients. The patients were enrolled from a neuro-oncology referral center in Yogyakarta, Indonesia. MiRNA-21 expression from plasma was measured by real-time quantitat

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Terret, Catherine, Gilles Albrand, Géraldine Moncenix, and Jean Pierre Droz. "Karnofsky Performance Scale (KPS) or Physical Performance Test (PPT)? That is the question." Critical Reviews in Oncology/Hematology 77, no. 2 (2011): 142–47. http://dx.doi.org/10.1016/j.critrevonc.2010.01.015.

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Sarkar, Krishna, Bineeta Kashyap, Rajat hamb, and S. V. Madhu. "Assessing Pulmonary Tuberculosis Using Bandim Tuberculosis and Karnofsky Performance Scale Scores with Serum Adenosine Deaminase Levels." Korean Journal of Family Medicine 44, no. 4 (2023): 234–39. http://dx.doi.org/10.4082/kjfm.22.0191.

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Background: Elevated pulmonary serum adenosine deaminase (ADA) levels signify lung tissue damage and severe tuberculosis (TB). Serum ADA assays can be used as an additional criterion for assessing TB treatment response and as a prognostic marker in patients with pulmonary TB. The Bandim TB and Karnofsky Performance Scale (KPS) scores were developed based on available clinical data and investigations to allow physicians to evaluate disease treatment and response. This study examined the use of a clinical scoring system (Bandim TB and KPS scores) in the context of serum ADA activity.Methods: For

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Salsabila, Khansa, Puji Pinta Omas Sinurat, and Irina Kemala Nasution. "Association between Coagulation Profile and Platelet Lymphocyte Ratio with Karnofsky Performance Status Scale In Brain Tumor Patients." Journal of Society Medicine 2, no. 5 (2023): 155–63. http://dx.doi.org/10.47353/jsocmed.v2i5.50.

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Introduction: Patients with tumor usually show abnormal laboratory coagulation tests, indicating a subclinical hypercoagulable state that contributes to morbidity and mortality. Hematologic markers such as the platelet-lymphocyte ratio (PLR) can be used as an index of tumor progression, high PLR is associated with morbidity and mortality in patients with primary or metastatic tumors. KPS is a method that is widely used to assess the functional status of a patient. The aim of this study is to determine the relationship between coagulation profile and platelet-lymphocyte with Karnofsky Performan

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Heba, Hassan Hanafy, Ahmed Fouad Wael, and Helmy Zidan Ihab. "Evaluation of the functional outcome in cases of penetrating brain injuries." Biolife 4, no. 4 (2022): 697–701. https://doi.org/10.5281/zenodo.7350610.

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<strong>ABSTRACT</strong> The purpose of this study is to evaluate the functional outcome in cases of penetrating brain injuries using Karnofsky performance scale (KPS). This prospective study was conducted to include 47 patients subjected to penetrating brain injury and admitted to the Emergency Department (ED) of Alexandria Main University Hospital from March 2014 to February 2016. Primary survey and secondary survey done for those patients, radiological investigations done including CT brain and other radiological investigations to exclude associated injuries (thoracic, abdominal injuries).

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Deng, Zhong, Hai Yu, Ning Wang, et al. "Impact of preoperative Karnofsky Performance Scale (KPS) and American Society of Anesthesiologists (ASA) scores on perioperative complications in patients with recurrent glioma undergoing repeated operation." Journal of Neurorestoratology 7, no. 3 (2019): 143–52. http://dx.doi.org/10.26599/jnr.2019.9040015.

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Objective:The objective of this study was to document the impact of the preoperative Karnofsky Performance Scale (KPS) and American Society of Anesthesiologists (ASA) scores on perioperative complications in patients with recurrent glioma who underwent tumor resection via craniotomy.Methods:A total of 96 patients were retrospectively reviewed. Based on KPS and ASA scores, patients were categorized into high KPS (> 70) or low KPS (≤ 70) and high ASA (3~4) or low ASA (1~2) groups. Differences in intraoperative risk factors and perioperative complications among the groups were analyzed. Multiv

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Algburi, Hagar A., Mustafa Ismail, Saad I. Mallah, et al. "Outcome measures in neurosurgery: Is a unified approach better? A literature review." Surgical Neurology International 14 (February 17, 2023): 61. http://dx.doi.org/10.25259/sni_949_2022.

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Background: Accurate assessment and evaluation of health interventions are crucial to evidence-based care. The use of outcome measures in neurosurgery grew with the introduction of the Glasgow Coma Scale. Since then, various outcome measures have appeared, some of which are disease-specific and others more generally. This article aims to address the most widely used outcome measures in three major neurosurgery subspecialties, “vascular, traumatic, and oncologic,” focusing on the potential, advantages, and drawbacks of a unified approach to these outcome measures. Methods: A literature review s

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Klingenschmid, Julia, Aleksandrs Krigers, Daniel Pinggera, et al. "Temporal Muscle Thickness Compared to Functional Scales as a Prognostic Parameter in Patients with Brain Metastases." Cancers 16, no. 9 (2024): 1660. http://dx.doi.org/10.3390/cancers16091660.

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Metastases are the most frequent intracranial malignant tumors in adults. While Karnofsky Performance Status (KPS) and Clinical Frailty Scale (CFS) are known to have significant impact on overall survival (OS), temporal muscle thickness (TMT) has been postulated to be a promising new parameter to estimate prognosis. Patients who received a resection of one to three brain metastases in our institution were included. Temporal muscle thickness was measured in preoperative MRI scans according to a standardized protocol. In 199 patients, the mean TMT was 7.5 mm (95CI 7.3–7.7) and the mean OS during

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Marina, Ovidiu, John H. Suh, Chandana A. Reddy, et al. "Treatment outcomes for patients with glioblastoma multiforme and a low Karnofsky Performance Scale score on presentation to a tertiary care institution." Journal of Neurosurgery 115, no. 2 (2011): 220–29. http://dx.doi.org/10.3171/2011.3.jns10495.

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Object The object of this study was to determine the benefit of surgery, radiation, and chemotherapy for patients with glioblastoma multiforme (GBM) and a low Karnofsky Performance Scale (KPS) score. Methods The authors retrospectively evaluated the records of patients who underwent primary treatment for pathologically confirmed GBM and with a KPS score ≤ 50 on initial evaluation for radiation therapy at a tertiary care institution between 1977 and 2006. Seventy-four patients with a median age of 69 years (range 19–88 years) and a median KPS score of 50 (range 20–50) were retrospectively group

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Chernov, Mikhail F., Kotaro Nakaya, Masahiro Izawa, et al. "Outcome After Radiosurgery for Brain Metastases in Patients With Low Karnofsky Performance Scale (KPS) Scores." International Journal of Radiation Oncology*Biology*Physics 67, no. 5 (2007): 1492–98. http://dx.doi.org/10.1016/j.ijrobp.2006.11.023.

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Machado, M., K. Roberto, J. Melhem, et al. "LONGITUDINAL NEUROLOGICAL ASSESSMENTS IN BRAIN TUMOR PATIENTS: CORRELATION BETWEEN NANO DOMAINS AND PERFORMANCE STATUS." Neuro-Oncology Advances 5, Supplement_2 (2023): i10. http://dx.doi.org/10.1093/noajnl/vdad071.042.

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Abstract The Karnofsky Performance Status (KPS) and Eastern Cooperative Oncology Group (ECOG) performance status are clinician-reported outcomes critical in guiding management and prognostication in patients with primary brain tumors as they can reflect longitudinal functional changes. However, they are subjective. The Neurologic Assessment in Neuro-Oncology (NANO) scale is a metric with specific neurological domains that was subsequently developed to provide an objective standardized measure of the neurologic functional status of patients, but how longitudinal changes in NANO scale relate to

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Panzer, Marissa, Elizabeth Vera, Alvina Acquaye, et al. "NCOG-47. CONGRUENCE BETWEEN PROVIDER REPORTED PERFORMANCE STATUS AND BOTH OBJECTIVE AND PERCEIVED COGNITION IN A GLIOMA POPULATION." Neuro-Oncology 23, Supplement_6 (2021): vi162. http://dx.doi.org/10.1093/neuonc/noab196.636.

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Abstract Karnofsky performance status (KPS) scale, a clinician-reported measure, is used to assess patients’ functional ability and as a metric for trial eligibility. Glioma patients often have a degree of neurologic deficit which can invariably affect performance status. There is little research comparing KPS, patient-reported cognitive outcomes, and objective cognitive outcomes. 273 primary brain tumor patients enrolled in the NOB Natural History Study were included in this report. We evaluated Pearson correlations between KPS (range 40-100), dichotomized as Good KPS (KPS ≥ 90) and Poor KPS

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Kafle, Prakash, Phelix Rufus, Nabin Paudyal, et al. "Perioperative Outcomes following Surgery of Brain Tumors: Assessment and Analysis of Risk Factors." Journal of Institute of Medicine Nepal 45, no. 2 (2023): 31–36. http://dx.doi.org/10.59779/jiomnepal.1263.

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Introduction: Cranial neurosurgery carries significant morbidity and mortality. Hence it is imperative to combine the latest available technological equipment with surgeon’s experience to prevent or reduce perioperative complications. It is also equally important to have a preoperative general assessment of the patient with functional status in particular to predict postoperative outcomes. Methods: This is a prospective study consisting of 122 patients selected over a period of 5 years (March 2017-March 2022). The patient database was retrieved from the medical record department, Nobel Institu

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Costa, Weruska Alcoforado, José Eleutério Jr., Paulo César Giraldo, and Ana Katherine Gonçalves. "Quality of life in breast cancer survivors." Revista da Associação Médica Brasileira 63, no. 7 (2017): 583–89. http://dx.doi.org/10.1590/1806-9282.63.07.583.

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Summary Objective: To evaluate the influence of functional capacity (FC) and how it affects quality of life (QoL) in breast cancer survivors. Method: A total of 400 breast cancer survivors were studied - 118 without metastasis, 160 with locoregional metastasis and 122 with distant metastasis. The European Organization for Research and Treatment for Cancer Quality of Life Questionnaire--Core 30 (EORTC QLQ-C30), Breast Cancer-Specific (EORTC QLQ-BR23), and the Karnofsky Performance Scale (KPS) were used to evaluate FC and QoL. Results: Women with distant metastases presented lower KPS 75.3 (SD=1

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Krigers, A., N. Pichler, J. Kerschbaumer, et al. "P08.04.B The Clinical Frailty Scale is superior to the Karnofsky Performance Status as predictor of overall survival in patients with surgical treatment of brain metastases." Neuro-Oncology 24, Supplement_2 (2022): ii43. http://dx.doi.org/10.1093/neuonc/noac174.148.

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Abstract Background The Clinical Frailty Scale (CFS) evaluates patients’ level of frailty on a scale from 1 (very fit) to 9 (terminally ill) and is commonly used in geriatric medicine, intensive care and orthopaedics but not in patients harboring neuro-oncological diseases. Our study was conducted to reveal if the usage of CFS generates more reliable prediction of overall survival in patients after brain metastases resection rather than Karnofsky Performance Status (KPS). Material and Methods All patients which were operated for brain metastatic disease at our department from 2005-2019 were in

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Ko, Eun-Bi, Kwon-Jun Jang, Jung-min Yang, and Jae-sung Oh. "A Case Report on Papillary Thyroid Cancer Patients after Thyroidectomy Treated with Korean Medicine and Immunotherapy." Journal of Internal Korean Medicine 42, no. 5 (2021): 746–59. http://dx.doi.org/10.22246/jikm.2021.42.5.746.

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Objectives: This study assessed the effect of a combination of Korean medicine and immunotherapy on three papillary thyroid cancer patients following thyroidectomy.Methods: The three patients who underwent thyroidectomy received Korean medical treatments, including acupuncture, moxibustion, pharmacopuncture, and immunotherapy. To evaluate the patients, symptoms were measured using the Numerical Rating Scale (NRS) and Karnofsky Performance Status Scale (KPS). Blood tests, including thyroid function tests, were conducted during treatment.Results: After treatment, postoperative pain and general w

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Klingenschmid, J., A. Krigers, D. Pinggera, J. Kerschbaumer, C. Thomé, and C. F. Freyschlag. "P08.02.B The Clinical Frailty Scale as predictor of overall survival after resection of high-grade glioma." Neuro-Oncology 24, Supplement_2 (2022): ii43. http://dx.doi.org/10.1093/neuonc/noac174.146.

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Abstract Background The Clinical Frailty Scale (CFS) describes the general level of fitness or frailty and is widely used in geriatric medicine, intensive care and orthopaedic surgery. This study was conducted to analyze, whether CFS could be used for patients with high-grade glioma. Material and Methods Patients harboring high-grade gliomas, undergoing first resection at our center between 2015 and 2020 were retrospectively evaluated. Patients’ performance was assessed using the Rockwood Clinical Frailty Scale and the Karnofsky Performance Scale (KPS) preoperatively and 3-6 months postoperati

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Ritarwan, Kiking, Irina Keumala Nasution, Iswandi Erwin, and Nerdy Nerdy. "Correlation of Leukocyte Subtypes, Neutrophil-to-Lymphocyte Ratio, and Functional Outcome in Brain Metastasis." Open Access Macedonian Journal of Medical Sciences 6, no. 12 (2018): 2333–36. http://dx.doi.org/10.3889/oamjms.2018.477.

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BACKGROUND: As the most cause of death in patients with solid extracranial malignancy, brain metastasis (BM) nowadays being studied extensively especially on how to find a reliable laboratory marker that can correlate with its clinical outcome. Leukocyte subtypes, primarily neutrophils and lymphocytes and its ratio known as Neutrophils-Lymphocyte Ratio (NLR) have been known before its relationship with progressivity of BM from other solid tumours. AIM: The objectives of this research to study the correlation of leukocyte subtypes, neutrophil-lymphocyte ratio & functional outcome in b

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Zhang, Linpeng, Chen Wang, Xueling Qi, et al. "Clinical Characteristics and Prognostic Risk Factors of Parasellar Chondrosarcoma." Brain Sciences 12, no. 10 (2022): 1353. http://dx.doi.org/10.3390/brainsci12101353.

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Background: Parasellar chondrosarcomas are extremely rare. This study describes the characteristics of parasellar chondrosarcoma and analyzes the risk factors and prognosis based on the resection degree. Methods: Fifteen patients with pathologically diagnosed parasellar chondrosarcoma were retrospectively analyzed for the clinical data, surgical methods, and prognosis to identify relationships between the surgical resection degree, tumor recurrence, and imaging characteristics. Results: Twelve patients had eye dysfunction and ptosis. Differentiation from other parasellar tumors by imaging is d

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Abdelhafeez, Ahmed A. M., Nafie F. Makady, Ola Hafez, Catherine N. Atallah, and Samy A. Alsirafy. "Reliability and validity of the Arabic translation of the palliative performance scale." Palliative and Supportive Care 18, no. 5 (2019): 575–79. http://dx.doi.org/10.1017/s1478951519000889.

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AbstractObjectiveThe aim of this study was to translate the Palliative Performance Scale (PPSv2) into Arabic and to test the reliability and validity of the PPS Arabic translation (PPS-Arabic).MethodThe PPSv2 was translated into Modern Standard Arabic using a forward–backward method. Inter-rater and intra-rater reliabilities were tested in a pilot study that included 20 patients. The validation study included 150 cancer patients. Patients were divided according to their treatment plan into three groups (in-remission, palliative chemotherapy, and best supportive care) to perform hypothesis-test

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de Kock, Ingrid, Mehrnoush Mirhosseini, Francis Lau, et al. "Conversion of Karnofsky Performance Status (Kps) and Eastern Cooperative Oncology Group Performance Status (Ecog) to Palliative Performance Scale (Pps), and the interchangeability of Pps and Kps in Prognostic Tools." Journal of Palliative Care 29, no. 3 (2013): 163–69. http://dx.doi.org/10.1177/082585971302900305.

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Chu, Nadia M., Zhan Shi, Christine Haugen, Dorry Segev, and Mara McAdams-DeMarco. "POST-TRANSPLANT FUNCTIONAL STATUS TRAJECTORY AMONG ADULT KIDNEY TRANSPLANT RECIPIENTS." Innovation in Aging 3, Supplement_1 (2019): S793. http://dx.doi.org/10.1093/geroni/igz038.2921.

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Abstract Frailty and disabilities are highly prevalent among kidney transplant (KT) recipients, but are not routinely measured in KT recipients. The Karnofsky Performance Scale (KPS) is a clinically perceived measure used to evaluate patient’s ability to manage daily activities, but little is known about its post-KT trajectories and its relationship to frailty and disability in KT recipients. We leveraged a cohort of 159,992 adult KT recipients from SRTR (1/2005-6/2018) and a cohort of 1,106 adult KT recipients from a prospective cohort study on aging and KT with recorded KPS (range 10%-100% i

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Ghoshal, A., A. Damani, N. Salins, J. Deodhar, and M. A. Muckaden. "Patient's Decisional Control Preferences in Palliative Care: An Indian Survey." Journal of Global Oncology 4, Supplement 2 (2018): 118s. http://dx.doi.org/10.1200/jgo.18.26000.

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Background: The frequency of passive decisional control (patients prefers physician to make decisions) has been reported to be variable but generally larger among patients living in developing countries. Aim: This study aimed to determine the frequency of passive DCP among patients with advanced cancer in a tertiary cancer center, and identify its association with their sociodemographic and clinical characteristics. Methods: 150 patients referred to palliative care underwent assessment of decisional control preferences using validated tools including control preference scale tool, satisfaction

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Friehs, Gerhard M., Joseph Legat, Zhen Zheng, Gerhard Pendl, and Georg C. Noren. "Outcomes in patients treated with gamma knife radiosurgery for brain metastases from malignant melanoma." Neurosurgical Focus 4, no. 6 (1998): E3. http://dx.doi.org/10.3171/foc.1998.4.6.4.

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In order to determine the effectiveness of gamma knife (GK) radiosurgery in patients with malignant melanoma metastases, the authors conducted a prospective multicenter study. :Forty-five patients with a total of 96 lesions were treated and followed to measure survival time, tumor control rate, and Karnofsky Performance Scale (KPS) score. The mean survival time was 8.7 months (median 4.2 months), and tumor control was achieved in 86% of lesions. When obtained, the median preoperative KPS of 80 was maintained at a median of 80 post-GK treatment. The authors found GK treatment for metastases of

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Kolakshyapati, Manish, Fusao Ikawa, Masaru Abiko, et al. "Multivariate risk factor analysis and literature review of postoperative deterioration in Karnofsky Performance Scale score in elderly patients with skull base meningioma." Neurosurgical Focus 44, no. 4 (2018): E14. http://dx.doi.org/10.3171/2018.1.focus17730.

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OBJECTIVEElderly patients are particularly at risk for severe morbidity following surgery. Among the various risk factors, age and skull base location of meningioma are known to be poor prognostic factors in meningioma surgery. The authors conducted this study to analyze significant preoperative risk factors in elderly patients with skull base meningioma.METHODSA total of 265 elderly patients (≥ 65 years old) with meningioma were surgically treated at the authors’ institute and affiliated hospitals between 2000 and 2016, and these cases were reviewed. Among them, 57 patients with skull base me

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San, Ali, Raphia K. Rahman, Praveen Sanmugananthan, et al. "Health-Related Quality of Life Outcomes in Meningioma Patients Based upon Tumor Location and Treatment Modality: A Systematic Review and Meta-Analysis." Cancers 15, no. 19 (2023): 4680. http://dx.doi.org/10.3390/cancers15194680.

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Patients with meningiomas may have reduced health-related quality of life (HRQoL) due to postoperative neurological deficits, cognitive dysfunction, and psychosocial burden. Although advances in surgery and radiotherapy have improved progression-free survival rates, there is limited evidence regarding treatment outcomes on HRQoL. This review examines HRQoL outcomes based on tumor location and treatment modality. A systematic search in PubMed yielded 28 studies with 3167 patients. The mean age was 54.27 years and most patients were female (70.8%). Approximately 78% of meningiomas were located i

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Nirmala, Made Sinta Ayu Suci, Putu Anda Tusta Adiputra, I. Gede Budhi Setiawan, and Ni Gusti Ayu Agung Manik Yuniawaty Wetan. "ANALYSIS OF FACTORS AFFECTING QUALITY OF LIFE OF HEAD AND NECK CANCER PATIENTS IN SANGLAH HOSPITAL." E-Jurnal Medika Udayana 11, no. 7 (2022): 7. http://dx.doi.org/10.24843/mu.2022.v11.i7.p02.

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Head and neck cancer ranked as the fifth most common cancer in the world. A series of treatment is likely to cause changes in the quality of life in cancer patients. This study aims to determine the factors that affect the patient's quality of life and the relationship between EORTC QLQ-H&N35 and Karnofsky Performance Scale (KPS). This study is analytic with a cross sectional approach. The technique is total sampling adjusted to the inclusion and exclusion criteria. Data obtained were gender, age, anatomical location of head and neck cancer, stage of cancer, therapy, KPS, and EORTC QLQ-H&a

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Juthani, Ronit, Panah Parab, and Kala Seetharaman. "Inclusion of patients with reduced performance status (ECOG 2 or higher) in FDA registrational trials for renal cell carcinoma (RCC)." Journal of Clinical Oncology 43, no. 5_suppl (2025): 453. https://doi.org/10.1200/jco.2025.43.5_suppl.453.

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453 Background: Clinical trials often use performance status indicators to include only those participants with good baseline functional status. The Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) and the Karnofsky Performance Scale (KPS) are two such scales that determine a cancer patient’s ability to perform common tasks. As a result, the study population does not accurately represent the real-world population. We evaluated the inclusion of patients with ECOG 2 or greater/ KPS less than 70 in RCC clinical trials leading to FDA approvals between 2014 and 2024. Methods: The U

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Pesce, Alessandro, Flavia Fraschetti, Giancarlo D'Andrea, et al. "Risk of Postoperative Performance Status Worsening after Resection of Lesions Involving the Motor Pathway: A Multinomial Logistic Regression Model." Journal of Neurological Surgery Part A: Central European Neurosurgery 79, no. 06 (2018): 453–63. http://dx.doi.org/10.1055/s-0037-1617756.

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Background and Study Objective In surgery for gliomas and brain metastases, preservation of neurologic functions is essential to ensure a good quality of life and the eligibility for adjuvant therapies. This article assesses which factors could influence the functional outcome in patients with lesions located in the motor pathways. Materials and Methods A total of 92 patients with gliomas and metastases involving the motor pathways were studied for concerns regarding quality of life (Karnofsky performance status [KPS] and modified Rankin scale [mRS]) before and after surgical treatment support

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Gupta, Meenu, Saurabh Bansal, Deep Shankar Pruthi, Manju Saini, Nadia Shirazi, and Mushtaq Ahmad. "Prognostic Factors in Elderly Patients with High-grade Gliomas: A Retrospective Analysis of 24 Cases." Journal of Neurosciences in Rural Practice 09, no. 03 (2018): 312–16. http://dx.doi.org/10.4103/jnrp.jnrp_576_17.

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ABSTRACT Background and Objectives: Due to the aging of the population, diagnosis of high-grade gliomas (HGGs) in the elderly is becoming more common. The purpose of this study was to report our experience in 24 elderly patients with HGGs and evaluate the value of different prognostic factors. Design and Setting: Retrospective analysis of 24 elderly patients of ≥60 years with newly diagnosed HGGs, who were treated at our department between January 2009 and December 2012, was done. Patients and Methods: Age, gender, Karnofsky performance scale (KPS) score, extent of surgery, and use of temozolo

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Williams, Taylor Raines, Koshy Alexander, Beatriz Korc-Grodzicki, Saman Sarraf, and Armin Shahrokni. "Preoperative evaluation of older cancer patients: Why some patients did not proceed with planned surgery." Journal of Clinical Oncology 35, no. 31_suppl (2017): 38. http://dx.doi.org/10.1200/jco.2017.35.31_suppl.38.

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38 Background: Older cancer patients may need to make challenging treatment decisions at the time of preoperative evaluation. This study assesses the reasons and outcomes of older cancer patients who did not proceed with planned surgery. Methods: This is a retrospective analysis of a cohort of 1767 older cancer patients who presented to the Geriatrics clinic for preoperative evaluation between 1/2015 and 12/2016. Differences in Geriatric Assessment between those who proceeded and did not proceed with surgery were assessed within a month after preoperative evaluation. Charts of those who did no

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Fischl, Anna, Michael Gerken, Patricia Lindberg-Scharf, et al. "Health-Related Quality of Life and Treatment Satisfaction of Patients with Malignant IDH Wild-Type Gliomas and Their Caregivers." Current Oncology 31, no. 10 (2024): 6155–70. http://dx.doi.org/10.3390/curroncol31100459.

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(1) Background: Clinical aspects like sex, age, Karnofsky Performance Scale (KPS) and psychosocial distress can affect the health-related quality of life (HR-QoL) and treatment satisfaction of patients with malignant isocitrate dehydrogenase wild-type (IDHwt) gliomas and caregivers. (2) Methods: We prospectively investigated the HR-QoL and patient/caregiver treatment satisfaction in a cross-sectional study with univariable and multiple regression analyses. Questionnaires were applied to investigate the HR-QoL (EORTC QLQ-C30, QLQ-BN20) and treatment satisfaction (EORTC PATSAT-C33). (3) Results:

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Boele, Florien, Se Frances, Amelie Darlix, et al. "QOL-14. HEALTH-RELATED QUALITY OF LIFE AND COGNITIVE FUNCTIONING IN SURVIVORS OF OLIGODENDROGLIOMA: AN INTERNATIONAL CROSS-SECTIONAL INVESTIGATION." Neuro-Oncology 26, Supplement_8 (2024): viii265. http://dx.doi.org/10.1093/neuonc/noae165.1049.

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Abstract BACKGROUND Patients with oligodendroglioma have a relatively favourable prognosis. Treatment modalities used vary, and the long-term impacts of the tumour itself and its treatment on health-related quality of life (HRQOL) and cognition remain largely unclear. We investigated associations between treatment and functioning of oligodendroglioma patients. METHODS In this international cross-sectional observational study, patients with oligodendroglioma (IDH-mutant and 1p/19q-codeleted) diagnosed ≥5 years ago, were recruited through the European Organisation for Research and Treatment of C

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Wu, Youtu, Chuzhong Li, Huifang Zhang, et al. "Emotional Problems, Quality of Life and Symptom Burden in Patients with Chordoma." Healthcare 11, no. 8 (2023): 1135. http://dx.doi.org/10.3390/healthcare11081135.

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Chordomas are very rare malignant bone tumors. Following surgery, their effects on neurological, physical, psychological, social, and emotional functioning are substantial and can have a major impact on a patients’ quality of life (QOL). In this survey, we aimed to characterize the postoperation health-related QOL and emotional problem in patients with chordoma using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire 30 (EORTC QLQ-C30) and Hamilton Depression Rating Scale (HAMD). The cohort included 100 patients who underwent resection surgery between

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Austin, Patricia, Sharon Wiley, Peter M. McEvoy, and Leigh Archer. "Depression and anxiety in palliative care inpatients compared with those receiving palliative care at home." Palliative and Supportive Care 9, no. 4 (2011): 393–400. http://dx.doi.org/10.1017/s1478951511000411.

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AbstractObjective:This study compared the prevalence of anxiety and depression as measured on the Hospital Anxiety and Depression Scale (HADS) in palliative care patients being treated at home with those being treated as inpatients.Method:The participants were palliative care patients being treated at home (n = 46) and palliative care inpatients (n = 46). Subjects were assessed for functionality on the Karnofsky Performance Status Scale (KPS) and anxiety and depression were measured on the HADS.Results:The results showed that ~20% of all patients were depressed and anxious as measured on the H

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Chang, V. T., N. Sambamoorthi, B. Zhou, et al. "Comorbidity and survival in cancer patients receiving palliative care." Journal of Clinical Oncology 25, no. 18_suppl (2007): 9066. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.9066.

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9066 Background: Comorbidity has received increasing attention in the assessment of patients with early stage cancer, or at diagnosis. We studied whether three indices of comorbidity, the Charlson Comorbidity Index (CMI), the Cumulative Illness Rating Scale (CIRS), and the Kaplan Feinstein Index (KFI) add prognostic information for cancer patients receiving palliative care. Methods: In an IRB approved protocol, 103 patients with advanced cancer were seen at the time they were starting palliative care. They had a Karnofsky Performance Status (KPS) determination, and were followed longitudinally

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Suzuki, Satoshi, Junichi Omagari, Shunji Nishio, Eiichiro Nishiye, and Masashi Fukui. "Gamma knife radiosurgery for simultaneous multiple metastatic brain tumors." Journal of Neurosurgery 93, supplement_3 (2000): 30–31. http://dx.doi.org/10.3171/jns.2000.93.supplement_3.0030.

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Object. The authors assessed the efficacy of gamma knife radiosurgery (GKS) in the treatment of patients with 10 or more simultaneous metastatic brain tumors. Methods. Gamma knife radiosurgery was performed for the treatment of 10 or more simultaneous metastatic brain tumors in 24 patients. The performance status before and after GKS was expressed using the Karnofsky Performance Scale (KPS). The cumulative survival rate was analyzed using the Kaplan—Meier method. The level of satisfaction with the procedure was assessed by telephone interview. No patient has died due to brain metastasis—relate

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Lona, Andre, Alfansuri Kadri, and Irina Kemala Nasution. "Correlation between Stage and Histopathological Features and Clinical Outcomes in Patients with Glioma Tumors." Open Access Macedonian Journal of Medical Sciences 9, T3 (2021): 262–64. http://dx.doi.org/10.3889/oamjms.2021.6296.

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BACKGROUND: Brain tumor incidence continues to increase during the last decade in several countries. Determining the response of intracranial tumors to treatment remains a major challenge in the field of neuro-oncology. Karnofsky Performance Status Scale (KPS) is a widely used method for assessing the functional status of a patient. AIM: This study aims to determine the relationship between stadium and histopathological features with clinical outcomes in patients with glioma tumors. METHODS: This was an observational analytic study with a retrospective approach at the H. Adam Malik General Hos

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Asano, Kenichiro, Takahiro Nakano, Tetsuji Takeda, and Hiroki Ohkuma. "Risk factors for postoperative systemic complications in elderly patients with brain tumors." Journal of Neurosurgery 111, no. 2 (2009): 258–64. http://dx.doi.org/10.3171/2008.10.17669.

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Object In elderly patients with brain tumors, the prevention of postoperative systemic complications is extremely important, and identification of the risk factors would be useful for planning therapy. The authors investigated ways to avoid postoperative complications by identifying risk factors. Methods The study population included 84 patients, 70 years of age or older, who underwent surgical brain tumor removal. The following independent factors were assessed by univariate and multivariate analyses: sex, age, preoperative underlying diseases and complications, histopathological findings, pr

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Abecassis, Isaac Josh, Brian Hanak, Jason Barber, Martin Mortazavi, and Richard G. Ellenbogen. "A Single-Institution Experience with Pineal Region Tumors: 50 Tumors Over 1 Decade." Operative Neurosurgery 13, no. 5 (2017): 566–75. http://dx.doi.org/10.1093/ons/opx038.

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Abstract BACKGROUND: Pineal region tumors are rare intracranial tumors that are more common in children than adults. Surgical management of tumors in this region using a tailored approach is a strategy that enhances extent of resection and neurological outcome. OBJECTIVE: To review our institutional experience with pineal region tumors in children and adults over the past 10 years. METHODS: Our institutional pathology database and patient records were retrospectively reviewed for details regarding clinical and radiological presentation, surgical management, extent of resection, morbidity, and

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Wilmoth, Margaret C., Alexandra L. Hanlon, Lit Soo Ng, and Debra W. Bruner. "Factor Analysis of the Modified Sexual Adjustment Questionnaire-Male." Journal of Nursing Measurement 22, no. 2 (2014): 241–54. http://dx.doi.org/10.1891/1061-3749.22.2.241.

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Background and Purpose: The Sexual Adjustment Questionnaire (SAQ) is used in National Cancer Institute–sponsored clinical trials as an outcome measure for sexual functioning. The tool was revised to meet the needs for a clinically useful, theory-based outcome measure for use in both research and clinical settings. This report describes the modifications and validity testing of the modified Sexual Adjustment Questionnaire-Male (mSAQ-Male). Methods: This secondary analysis of data from a large Radiation Therapy Oncology Group trial employed principal axis factor analytic techniques in estimating

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Abrahams, John M., Maria Torchia, Mary Putt, Larry R. Kaiser, and Kevin D. Judy. "Risk factors affecting survival after brain metastases from non—small cell lung carcinoma: a follow-up study of 70 patients." Journal of Neurosurgery 95, no. 4 (2001): 595–600. http://dx.doi.org/10.3171/jns.2001.95.4.0595.

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Object. The authors present their experience with the treatment of brain metastases from non—small cell lung carcinoma (NSCLC). Methods. A retrospective review was conducted in which records from 74 patients treated at the authors' institution between 1994 and 1999 were assessed. Survival and functional outcome were reviewed relative to individual patient variables. The median survival time was 12.9 months, with 1-, 2-, and 5-year survival milestones reached by 52.2%, 30.7%, and 18.1% of patients, respectively. Patients were stratified into groups composed of those with synchronous brain metas

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Koepke, Leon-Gordian, Lukas Weiser, Martin Stangenberg, et al. "Outcome after Posterior Vertebral Column Resection in Patients with Severe Osteoporotic Fractures—A Retrospective Analysis from Two Centers." Medicina 58, no. 2 (2022): 277. http://dx.doi.org/10.3390/medicina58020277.

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Background and Objectives: In osteoporotic fractures of the spine with resulting kyphosis and threatening compression of neural structures, therapeutic decisions are difficult. The posterior vertebral column resection (pVCR) has been described by different authors as a surgical treatment in a single-stage posterior procedure. The aim of this study is to evaluate midterm outcomes of patients treated by pVCR due to severe osteoporotic fractures. Materials and Methods: Retrospective data analysis of all the patients treated for osteoporotic fractures by pVCR from 2012–2020 at two centers was perf

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Rahmawati, Dessika, Badrul Munir, Nanik Setijowati, Catur Ari Setianto, Ria Damayanti, and Bimo Mubyarto. "FACTORS AFFECTING THE FUNCTIONAL STATUS OF PATIENT WITH MENINGIOMA IN DR. SAIFUL ANWAR GENERAL HOSPITAL MALANG." MNJ (Malang Neurology Journal) 9, no. 1 (2023): 76–80. http://dx.doi.org/10.21776/ub.mnj.2023.009.01.17.

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Background: Meningioma is one of the most commonly reported primary central nervous system (CNS) tumors, originating from arachnoid meningeal cells and including intracranial extra-axial neoplasms. Although meningioma is considerably benign, the patient conditions are reported to be diverse resulting in severe and life-threatening neurological deficits. Hence the assessment regarding functional status is deemed pivotal to provide a prognostic perspective as patient presentation exhibits disability due to lesions and other factors. Objective: This research aims to analyze factors affecting the

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Belli, Gianfranco, Marcello Tamburini, and Eugenio Paci. "What Do Italian Hospital Physicians Know about Quality of Life Assessment in Oncology?" Tumori Journal 80, no. 1 (1994): 24–27. http://dx.doi.org/10.1177/030089169408000104.

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Aims To assess the current level of information and use of quality of life assessment instruments by Italian physicians involved in oncologic patient care. Methods Specifically trained scientific representatives of a pharmaceutical company interviewed 2237 hospital physicians all over Italy. Results A total of 1390 physicians (62.1%) had some knowledge of quality of life assessment tools in oncology, but 364 of them (26.2%) were unable to recall the name of any instruments. The one that was most frequently recalled by the 1026 physicians who knew of the existence of one or more instruments was

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Luna-Ortiz, Kuauhyama, Ethel R. Núñez-Valencia, Mario Tamez-Velarde, and Martin Granados-Garcia. "Quality of life and functional evaluation after supracricoid partial laryngectomy with cricohyoidoepiglottopexy in Mexican patients." Journal of Laryngology & Otology 118, no. 4 (2004): 284–88. http://dx.doi.org/10.1258/002221504323012030.

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This study assessed the functional results in patients treated primarily through supracricoid partial laryngectomy (SCPL) with cricohyoidoepiglottopexy (CHEP).Fifteen patients with a diagnosis of epidermoid carcinoma of the glottis region admitted to the Instituto Nacional de Cancerología (México) between June 2001 and September 2002 were studied. Three patients were at stage I, five at stage II, six at stage III, and one at stage IV. Both cricoarytenoid units were preserved in 12 patients, and only one in three. Each case was assessed through the clinical grading postoperative aspiration (CGP

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Ganguly, Apurba, and Devika Ganguly. "A novel approach for failed lumbar spine surgery with topical phytotherapeutic treatment: a unique case study." Journal of Drug Delivery and Therapeutics 8, no. 6-s (2018): 135–40. http://dx.doi.org/10.22270/jddt.v8i6-s.2214.

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Objective: The aim of the study was to treat successfully the failed Lumbar Spinal Fusion Surgery (LSFS) with topical phytotherapy within twelve-week. Methods: A male patient, aged 45years, was cripple with acute pain due to slipped disc for 4years and subsequently undergone LSFS at L4-L5 3years back. Being failed in surgery, he was treated with topical application of phytoextracts of seven medicinal plants (Cissus quadrangularis, Calotropis gigantea, Zingiber officinalis, Rosemarinus officinalis, Boswellia serratia, Curcuma longa and Withania somnifera) mixed with sesame oil and beeswax

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Ganguly, Apurba. "Role of Jumpstart Nutrition®, a Dietary Supplement, to Ameliorate Calcium-to-Phosphorus Ratio and Parathyroid Hormone of Patients with Osteoarthritis." Medical Sciences 7, no. 12 (2019): 105. http://dx.doi.org/10.3390/medsci7120105.

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The aim of this study was to use Jumpstart Nutrition® bone supplementing combination with vitamin-K2 and coenzyme-Q10 characterized by an innovative delivery system that improves bioavailability of calcium-to-phosphorus ratio (CPR) and parathyroid hormone (PTH) in the management of osteoarthritis (OA). This eight-week registry included 108 patients treated for symptomatic OA confirmed with radiological images. On top of that, 63 patients used Jumpstart Nutrition® supplement, mainly prepared with calcium, phosphorus, coenzyme-Q10, vitamin-K2, vitamin-D2, vitamin-C, folic acid, curcumin and bosw

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Wilhelmy, Bradley, Riccardo Serra, Chixiang Chen, et al. "An analysis of functional outcomes following laser interstitial thermal therapy for recurrent high-grade glioma." Neurosurgical Focus 57, no. 5 (2024): E4. http://dx.doi.org/10.3171/2024.8.focus24460.

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OBJECTIVE Laser interstitial thermal therapy (LITT) is an emerging tool for treating a variety of focal brain lesions, including recurrent high-grade glioma (HGG). While the efficacy and uses of LITT have been well studied, the impact of this treatment on patient functional outcomes has not been analyzed in detail. This study sought to better define the role of LITT in treating patients with recurrent HGG, examining which patients exhibit good functional outcomes after LITT, and to determine risk factors for worsening neurological function. METHODS The medical records of patients treated with

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