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Journal articles on the topic 'Karolinska Institutet'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 July 2024

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1

Eliasson, Erik, Sarah C. Sim, Anders Rane, and Magnus Ingelman-Sundberg. "Institutional Profile: Karolinska Institutet." Pharmacogenomics 13, no. 16 (December 2012): 1887–91. http://dx.doi.org/10.2217/pgs.12.176.

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2

Ahlberg, Carina. "MOOCs at Karolinska Institutet University Library." Insights: the UKSG journal 27, no. 2 (July 1, 2014): 160–65. http://dx.doi.org/10.1629/2048-7754.116.

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3

Wallberg-Henriksson, Harriet. "Gender equality at the Karolinska Institutet." Gender Medicine 2, no. 2 (June 2005): 62–64. http://dx.doi.org/10.1016/s1550-8579(05)80011-7.

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4

Södersten, Per, Sven Ove Ögren, and Åke Seiger. "Karolinska Institutet Special Issue on Neuroscience." Physiology & Behavior 92, no. 1-2 (September 2007): v. http://dx.doi.org/10.1016/s0031-9384(07)00343-5.

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5

Ingebrigtsen, Erik. "Perspektivrikt om Karolinska Institutet og amerikansk filantropi." Tidsskrift for Den norske legeforening 131, no. 13-14 (2011): 1328–29. http://dx.doi.org/10.4045/tidsskr.11.0439.

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6

Main, Heather, Mona Hedenskog, Ganesh Acharya, Outi Hovatta, and Fredrik Lanner. "Karolinska Institutet Human Embryonic Stem Cell Bank." Stem Cell Research 45 (May 2020): 101810. http://dx.doi.org/10.1016/j.scr.2020.101810.

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7

Ekberg, Sara, Karin E. Smedby, Alexandra Albertsson-Lindblad, Mats Jerkeman, Caroline Weibull, and Ingrid Glimelius. "Late Effects after Treatment in Mantle Cell Lymphoma: No Difference By Intensity of First-Line Regimens with or without Autologous Stem Cell Transplantation." Blood 138, Supplement 1 (November 5, 2021): 1344. http://dx.doi.org/10.1182/blood-2021-145450.

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Abstract Purpose The improved survival for mantle cell lymphoma (MCL) patients calls for updated knowledge about long-term adverse effects of treatment. We recently showed that younger MCL patients (≤65 years of age) selected for rituximab-cytarabine containing regimens and a consolidating high-dose chemotherapy with stem cell transplantation (HD-ASCT) had a 42% reduced all-cause mortality compared to patients selected for less intensive regimens with rituximab-bendamustine and/or rituximab-CHOP based treatment without HD-ASCT (non-HD-ASCT) (Blood Advances 2021, PMID: 3371034). The aim here was to describe long-term side-effects and outcome from these different treatment strategies. Methods We conducted a population-based cohort study including all Swedish MCL patients diagnosed between 2000 and 2014, and 1:10 matched comparators. First, transplantation-related mortality and acute side effects (within 60 days of HD-ASCT) were described. Next, for the analysis of late effects, we took a landmark approach with follow-up starting at 12 months after diagnosis (i.e., assuming treatment completion). Hazard ratios with 95% confidence intervals (CIs) of first hospital visit/admission/death due to a specific disease group (based on ICD chapters) were estimated using Cox regression models, comparing the rates among HD-ASCT and non-HD-ASCT patients to those among the comparators. Additionally, the 5-year cumulative incidence of death due to MCL, other malignancy, cardiovascular disease, or remaining causes was described for both patient treatment groups (HD-ASCT and non-HD-ASCT) and comparators. Results A total of 620 MCL patients were included with a median follow-up from diagnosis of 4.1 years (range: 0-15.7). In total, 280 (45%) received HD-ASCT (median age 58, range 32-69) and 340 (55%) R-CHOP/R-Bendamustin and non-HD-ASCT (median age 65, range 22-69). Four out of 280 (1.5%) HD-ASCT treated patients died within 60 days of their transplantation. Acute side effects of transplantation were mainly infections and diseases of the circulatory or digestive systems. In relation to the 6,200 matched comparators (median age 63, range 22-70) the rate of hospital visits/admissions/death after 12 months was significantly higher among MCL patients (irrespective of treatment intensity) for neoplasms (excluding MCL), other blood disorders, infections, respiratory, genitourinary, digestive, and skin disorders (Figure 1A). Patients treated with HD-ASCT did not experience a higher rate of late effects than those treated without HD-ASCT, for any of the disease groups (Figure 1A). The 5-year cumulative incidence of MCL-specific death in HD-ASCT treated patients was 0.23 (95% CI: 0.18-0.30) and 0.32 (95% CI: 0.26-0.38) in non-HD-ASCT treated patients (Figure 1B). Fatal long-term (≥12 months) side effects were rare in HD-ASCT treated patients, and the absolute majority of MCL patients died from their lymphoma and not from a complication. Conclusions MCL patients have a higher risk of long-term complications than comparators particularly in the disease groups respiratory disorder, blood disorders (other than MCL) and infections. Intensive first-line treatment including HD-ASCT was however associated with a similar rate of long-term side-effects in all disease groups as among patients selected for less intensive treatments and non-HD-ASCT. Hence, given the previously shown favourable long-term survival associated with HD-ASCT, it appears that this treatment should not be avoided based on fear of neither fatal acute side effects nor more long-term side effects. Instead symptomatic lymphoma disease and death from the lymphoma seem to drive the majority of long-term health problems in MCL patients regardless of treatment intensity. Figure 1. A) Hazard ratios for hospital visits/admissions/deaths due to specific disease groups (based on ICD chapters) among MCL patients and comparators, stratified by treatment with consolidative autologous stem cell transplant (ASCT) or (non-ASCT). All models were adjusted for age at diagnosis, sex, calendar year of diagnosis, and Charlson comorbidity index. Grey dots; comparators, blue dots MCL patients (non-ASCT-treated) and red dots MCL patients (ASCT treated) B) Cumulative incidence of death due to MCL, other malignancies, cardiovascular disease (CVD), and other causes among MCL patients without (upper panel) and with (lower panel) ASCT. Figure 1 Figure 1. Disclosures Ekberg: Jansen-Cilag: Other: part of a research collaboration between Karolinska Institutet and Janssen Pharmaceutica NV for which Karolinska Institutet has received grant support. Smedby: Jansen-Cilag: Other: part of a research collaboration between Karolinska Institutet and Janssen Pharmaceutica NV for which Karolinska Institutet has received grant support. Albertsson-Lindblad: Jansen-Cilag: Other: part of a research collaboration between Karolinska Institutet and Janssen Pharmaceutica NV for which Karolinska Institutet has received grant support. Jerkeman: Jansen-Cilag, AbbVie, Gilead, Celgene: Other: part of a research collaboration between Karolinska Institutet and Janssen Pharmaceutica NV for which Karolinska Institutet has received grant support, Research Funding. Weibull: Jansen-Cilag: Other: part of a research collaboration between Karolinska Institutet and Janssen Pharmaceutica NV for which Karolinska Institutet has received grant support. Glimelius: Jansen-Cilag: Other: part of a research collaboration between Karolinska Institutet and Janssen Pharmaceutica NV for which Karolinska Institutet has received grant support.

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8

Svartz, Nanna. "The Departments of Internal Medicine at Karolinska Institutet." Acta Medica Scandinavica 168, no. 4 (April 24, 2009): 235–44. http://dx.doi.org/10.1111/j.0954-6820.1960.tb13447.x.

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9

Blombäck, Margareta. "Molecular aspects in clinical hemostasis research at Karolinska Institutet." Biochemical and Biophysical Research Communications 396, no. 1 (May 2010): 131–34. http://dx.doi.org/10.1016/j.bbrc.2010.03.095.

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10

Felländer-Tsai, Li, Petter Westfelt, Cecilia Escher, Mats Hedsköld, and Ann Kjellin. "The Center for Advanced Medical Simulation, Karolinska Institutet, Karolinska University Hospital, and Stockholm County Council." Journal of Surgical Education 67, no. 5 (September 2010): 344–47. http://dx.doi.org/10.1016/j.jsurg.2010.05.013.

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11

Jörnvall, Hans. "Karolinska Institutet and the Nobel Prize in Physiology or Medicine." TRENDS IN THE SCIENCES 7, no. 7 (2002): 48–52. http://dx.doi.org/10.5363/tits.7.7_48.

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12

Editorial Team. "EBLIP5 Website Up and Running." Evidence Based Library and Information Practice 2, no. 4 (December 12, 2007): 122. http://dx.doi.org/10.18438/b8v61z.

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The University Library at Karolinska Institutet would like to welcome you to the 5th Evidence Based Library and Information Practice Conference in Stockholm, Sweden, June 29th - July 3rd 2009. Further details, including information about the venue and the conference organizers, can be found by visiting the new EBLIP5 website at http://eblip5.kib.ki.se.

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13

Paul, Robert, and Brian David Hodges. "The Karolinska Institutet Prize for Research in Medical Education: A history." Medical Teacher 42, no. 6 (March 12, 2020): 657–62. http://dx.doi.org/10.1080/0142159x.2020.1731441.

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14

Haya, Glenn, Sara M. Lind, and Sara Janzen. "Using a social platform as an internal communication tool: A case study." College & Research Libraries News 81, no. 1 (January 6, 2020): 14. http://dx.doi.org/10.5860/crln.81.1.14.

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In 2017, the Karolinska Institutet University Library conducted a project to replace the existing Intranet with a new improved tool. At the start of the project, we assumed it would result in a new, improved version of the existing Intranet. However, the project group eventually decided to replace the original Intranet with a combination of three tools that we believed would better meet the library staff’s needs.

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15

Ali, Moosa Zulfiqar, Roshaan Ahmad, and Amna Akmal. "Stockholm3 - A new option to detect Prostate Cancer." Journal of the Pakistan Medical Association 72, no. 4 (April 5, 2022): 784. http://dx.doi.org/10.47391/jpma.5109.

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Prostate cancer is the second most often diagnosed cancer and the sixth most prevalent cause of cancer mortality in males globally.1 It is usually screened by measuring prostate specific antigen (PSA) levels in the blood. However, the PSA test results in unnecessary biopsies, over-diagnosis, over-treatment, and higher expenses.2 The Karolinska Institutet in Stockholm, Sweden, developed the Stockholm3 test to overcome PSA test’s shortcomings. ---Continue

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16

Ahlberg, Carina. "The library as a physical learning environment at the Karolinska Institutet University Library." Journal of EAHIL 16, no. 2 (June 24, 2020): 24–28. http://dx.doi.org/10.32384/jeahil16390.

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This article describes the development of the learning environment in the library at Karolinska Institute. It all began with a university-wide project, but when taking into consideration what makes a library special, the librarians had to find their own application of the pedagogical thoughts behind the project. The students' needs are changing depending on situations and times, so the library environment needs to be flexible and regularly updated accordingly.

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17

Hassan, Moustapha, Per Ljungman, Rui He, Svante Norgren, Wenyi Zheng, Ying Zhao, Agneta Månsson-Broberg, Eva Wardell, and Terra Slof. "N-Acetylcysteine Amide Alleviates Cyclophosphamide-Induced Endothelial Damage." Blood 138, Supplement 1 (November 5, 2021): 3821. http://dx.doi.org/10.1182/blood-2021-152815.

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Abstract Rui He 1,2, Wenyi Zheng 1,2, Terra Slof 3, Eva Wärdell 4, Agneta Månsson-Broberg 4, Svante Norgren 5, Per Ljungman 2, Ying Zhao 1, 2 , Moustapha Hassan 1, 2 Experimental Cancer Medicine, Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, 141 86 Huddinge, Sweden Center of Allogeneic Stem Cell Transplantation (CAST) and Clinical Research Center, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. Institute for Life Sciences and Chemistry, HU University of Applied Sciences Utrecht, Oudenoord 330, 3513 EX Utrecht, Netherlands Department of Medicine, Division of Cardiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. Children´s and Women´s Health Theme, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden Aim The current study aimed to investigate the protective role of the novel antioxidant N-acetylcysteine amide (NACA) in cyclophosphamide (Cy)-induced endothelial injury and to explore the underlying mechanism. Background The alkylating agent Cy is still one of the important corner stones in cancer treatment. Cy is used also as a part of the conditioning regimens prior to hematopoietic cell transplantation (HCT) and as a prophylactic treatment post transplantation in graft-versus-host disease (GVHD). Several studies have shown that high doses of Cy are associated with a number of adverse effects including alopecia, gonadal toxicity, hemorrhagic cystitis, carcinogenesis and late cardiovascular toxicity. Moreover, we have shown that treatment with high-dose Cy caused damage to the arterial endothelium, which might contribute to late cardiovascular disorders. Hitherto, there is no prophylactic strategy for Cy-induced endothelial toxicity. Oxidative stress is one of the main players in the pathogenesis of endothelial disorders and hence is an exploitable trait for targeted treatment. Methods The prophylactic efficacy of NACA was evaluated using human aortic endothelial cells (HAECs) and human umbilical endothelial cells (HUVECs). The efficacy of NACA was compared with the clinically approved derivative N-acetylcysteine (NAC). Cy is a prodrug that cannot be activated in the endothelial cells. Therefore, cells were incubated with Cy active metabolite, 4-hydroxycyclophosphamide (4-OH-Cy). In order to reveal the underling mechanism of action, we have investigated and evaluated the following parameters: alteration in cell morphology, cell death pathway, inhibition of DNA damage, variation of redox hemostasis, and neovascularization. Results We found that pre-incubation with 5 mM NACA preserved the normal endothelial cell morphology. However, for the quantification of the obtained results, cell colonies were visualized using crystal violet staining while cell viability was determined using WST-1 assay. Moreover, NACA was found to decrease 4-OH-Cy-induced DNA damage and cell death via caspase-dependent apoptosis in both HAECs and HUVECs. In addition, NACA significantly inhibited 4-OH-Cy-induced oxidative stress by reducing the intracellular levels of reactive oxygen species (ROS) and by improving the cellular antioxidative capacity. Increased activities of catalase and superoxide dismutase (SOD) together with increased levels of reduced glutathione (GSH) were observed. Meanwhile, NACA pre-treatment rebalanced endothelial nitric oxide synthase (eNOS) and arginase I in HAECs, suggesting that NACA may be used as prophylactic strategy to avoid the impaired endothelium-dependent vasodilation caused by 4-OH-Cy. Moreover, data from tube formation assay indicated that NACA preserved the angiogenic capability of endothelial cells that was compromised by 4-OH-Cy through blockage of Notch signaling pathway. Our results showed that in contrast to NAC, its amide derivative NACA showed remarkably superior ability in alleviating the endothelial damage caused by 4-OH-Cy. Conclusions In summary, the present investigation showed that the novel antioxidant NACA could be applied to protect against 4-OH-Cy-induced endothelial cell dysfunction and death. Higher bioavailability and better cellular uptake make NACA to a better prophylactic agent compared to NAC. To translate these findings into the clinic, additional in vivo studies are warranted to confirm the protective potential of NACA. Disclosures Ljungman: Takeda: Consultancy, Other: Endpoint committee, speaker; Janssen: Other: Investigator; OctaPharma: Other: DSMB; Enanta: Other: DSMB; Merck: Other: Investigator, speaker; AiCuris: Consultancy.

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Dahllöf, Göran, Jan Ekstrand, and Jörgen Nordenström. "Portfolio of qualifications: a tool for evaluating academic productivity at the Karolinska Institutet." European Journal of Dental Education 3, no. 1 (February 1999): 31–34. http://dx.doi.org/10.1111/j.1600-0579.1999.tb00064.x.

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19

Board, Editorial. "MATERIALS OF INTERNATIONAL VACTRAIN/ 3-rd SWEDISH-UKRAINIAN CONFERENCE ON CANCER DISEASES, JANUARY 16–17, 2017, STOCKHOLM, SWEDEN." Experimental Oncology 39, no. 1 (March 22, 2017): 88–93. http://dx.doi.org/10.31768/2312-8852.2017.39(1):88-93.

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The scientific conference ‘‘International VACTRAIN/ 3-rd Swedish-Ukrainian conference on cancer diseases’’ was held on January 16–17, 2017 at Karolinska Institutet, Stockholm, Sweden. These 1.5 days were filled with the lectures by the invited speakers and oral presentations selected on the basis of submitted abstracts from younger researchers. The meeting was focused on what we have learnt over the recent times, on the current situation, and on the important challenges for the future with focus on combating cancer.

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20

Beasley, Gerald. "Ove Hagelin (comp.), Rare and important medical books in the library ofthe Karolinska Institute, Stockholm, Karolinska Institutet Bibliotek, 1992, pp. 212, illus., SEK 400 (91-88194-027)." Medical History 38, no. 02 (April 1994): 219. http://dx.doi.org/10.1017/s0025727300059251.

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21

Lunell, Nils-Olov, Sam Brody, Kjell Carlstr�m, Bengt Fredricsson, Owe Gustafson, Lars Nylund, �ke Pousette, Lennart Rosenborg, H�kan Slotte, and Eva �kerl�f. "A scheduled in vitro fertilization program at Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden." Journal of In Vitro Fertilization and Embryo Transfer 4, no. 6 (December 1987): 357–58. http://dx.doi.org/10.1007/bf01555389.

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22

Falk, Erik. "Utmaningen med utmaningsdriven utbildning." Högre utbildning 9, no. 1 (2019): 38. http://dx.doi.org/10.23865/hu.v9.1060.

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Utbildningsprogram, kurser eller kursmoment där studenter arbetar med utmaningar, ofta formulerade av samarbetsparter utanför akademin – vilka ibland benämns ”challenge-based learning” – kan bidra till relevans och verklighetsanknytning i undervisning samt främja generella förmågor som samarbete, kommunikationsförmåga och kritiskt och analytiskt tänkande. Men utbildningsformen skapar också en rad problem kring undervisningsadministration, examinationsformer och organisation eftersom den bryter mot etablerade arbetssätt och traditioner inom universitetsväsendet. Den här texten beskriver och reflekterar över praktiska och pedagogiska erfarenheter från Södertörns högskola i arbetet med att etablera en lärosätesgemensam utmaningsbaserad kurs tillsammans med Karolinska Institutet och med samverkansparterna Huddinge och Botkyrka kommuner.

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23

Neu, U., J. Wang, D. Macejak, R. L. Garcea, and T. Stehle. "Structures of the Major Capsid Proteins of the Human Karolinska Institutet and Washington University Polyomaviruses." Journal of Virology 85, no. 14 (May 4, 2011): 7384–92. http://dx.doi.org/10.1128/jvi.00382-11.

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24

Holst, Sarah, and Sara Hägg. "Positive bias for European men in peer reviewed applications for faculty position at Karolinska Institutet." F1000Research 6 (December 18, 2017): 2145. http://dx.doi.org/10.12688/f1000research.13030.1.

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Background: Sweden is viewed as an egalitarian country, still most of the professors are Swedish and only 25% are women. Research competence is evaluated using peer review, which is regarded as an objective measure in the meritocracy system. Here we update the investigation by Wold & Wennerås (1997) on women researcher’s success rate for obtaining a faculty position, by examining factors (gender, nationality, productivity, etc.) in applications for an Assistant Professorship in 2014 at Karolinska Institutet. Methods: Fifty-six applications, 26 Swedish and 21 women applicants, were scored both on merits and projects by six external reviewers. Additional variables, including grants and academic age, calculated as the number of years since PhD excluding parental or sick leave, were gathered. Productivity was assessed by calculating a composite bibliometric score based on six factors (citations, publications, first/last authorships, H-index, high impact publication). Results: Overall, academic age was negatively correlated with scores on merits, as assessed by peer review, although not reaching statistical significance. In men, associations between scores on merits and productivity (P-value=0.0004), as well as having received grants (P-value=0.009) were seen. No associations were found for women. Moreover, applicants with a background from the Middle East were un-proportionally found in the lowest quartile (Fisher exact test P-value=0.007). Conclusions: In summary, the gender inequality shown in peer review processes in Sweden 20 years ago still exists. Furthermore, a bias for ethnicity was found. In order to keep the best scientific competence in academia, more efforts are needed to avoid selection bias in assessments to enable equal evaluations of all researchers.

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Holst, Sarah, and Sara Hägg. "Positive bias for European men in peer reviewed applications for faculty position at Karolinska Institutet." F1000Research 6 (August 14, 2018): 2145. http://dx.doi.org/10.12688/f1000research.13030.2.

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Background: Sweden is viewed as an egalitarian country, still most of the professors are Swedish and only 25% are women. Research competence is evaluated using peer review, which is regarded as an objective measure in the meritocracy system. Here we update the investigation by Wold & Wennerås (1997) on women researcher’s success rate for obtaining a faculty position, by examining factors (gender, nationality, productivity, etc.) in applications for an Assistant Professorship in 2014 at Karolinska Institutet. Methods: Fifty-six applications, 26 Swedish and 21 women applicants, were scored both on merits and projects by six external reviewers. Additional variables, including grants and academic age, calculated as the number of years since PhD excluding parental or sick leave, were gathered. Productivity was assessed by calculating a composite bibliometric score based on six factors (citations, publications, first/last authorships, H-index, high impact publication). Results: Overall, academic age was negatively correlated with scores on merits, as assessed by peer review, although not reaching statistical significance. In men, associations between scores on merits and productivity (P-value=0.0004), as well as having received grants (P-value=0.009) were seen. No associations were found for women. Moreover, applicants with a background from the Middle East were un-proportionally found in the lowest quartile (Fisher exact test P-value=0.007). Conclusions: In summary, the gender inequality shown in peer review processes in Sweden 20 years ago still exists. Furthermore, a bias for ethnicity was found. In order to keep the best scientific competence in academia, more efforts are needed to avoid selection bias in assessments to enable equal evaluations of all researchers.

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26

Kühner, Sofia, Solvig Ekblad, Jan Larsson, and Jenny Löfgren. "Global surgery for medical students – is it meaningful? A mixed-method study." PLOS ONE 16, no. 10 (October 7, 2021): e0257297. http://dx.doi.org/10.1371/journal.pone.0257297.

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Introduction There has been an increase in global health courses at medical universities in high-income countries. Their effect on students, however, is poorly understood. In 2016 an elective global surgery course was introduced for medical students at Karolinska Institutet in Sweden. The course includes a theoretical module in Sweden and a two-week clinical rotation in Uganda. The present study aimed to assess the format and determine its effect on students’ knowledge of global surgery and approach towards patients of non-Swedish origin. Method A mixed-methods design was used. Semi-structured case-based interviews were conducted individually with 18 students and analysed using qualitative content analysis. Examination scores and the course evaluation were analysed with Kruskal Wallis one-way analysis of variance, Pearson’s Chi-square and a Wilcoxon signed-rank test as appropriate. Results The course was appreciated and students reported gained insights and interest in global surgery. Students’ ability to reason about global surgery issues was improved after the course. Students considered complicating aspects in the meeting with patients of non-Swedish origin. Students with abroad clinical experience felt less compelled to act on preconceptions. Discussion The global surgery course at Karolinska Institutet is appreciated and students gained valuable knowledge. The case-based interviews acted as a catalyst for reflection and showed that students felt insecure as they lacked knowledge about globally common surgical conditions and struggled with generalized preconceptions of patients of non-Swedish origin. To further support students to integrate theoretical knowledge and professional development, we suggest the introduction of problem-based learning. Conclusion The ability of the course to inspire students’ commitment to global surgery is promising as this engagement is the key to reaching the goal of equitable health globally. Offering such courses is a step towards inspiring and recruiting the future clinicians and researchers needed for expanding the field of global surgery.

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Wallberg-Henriksson, Harriet. "Erratum to “Preface by the President of the Karolinska Institutet” [Physiology & Behavior 92 (2007) vii]." Physiology & Behavior 93, no. 4-5 (March 2008): 1086. http://dx.doi.org/10.1016/j.physbeh.2007.11.040.

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28

Roding, Karin. "Perceptions of admission committee members: some aspects on individual admission to dental education at Karolinska Institutet." European Journal of Dental Education 9, no. 3 (August 2005): 115–22. http://dx.doi.org/10.1111/j.1600-0579.2005.00353.x.

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29

Kovalevska, L., and E. Kashuba. "MATERIALS OF NOBEL SYMPOSIUM 175: PRECISION MEDICINE TRANSFORMS HEALTHCARE: A NEW TRAJECTORY FOR RESEARCH AND INNOVATION SEPTEMBER 20—22, 2023, STOCKHOLM, SWEDEN." Experimental Oncology 45, no. 4 (February 3, 2024): 531–34. http://dx.doi.org/10.15407/exp-oncology.2023.04.531.

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Nobel Symposium 175 was organized by Professor Richard Rosenquist Brandell of Karolinska Institutet and was supported by the Royal Swedish Academy of Sciences. The focus of the symposium was a discussion on the development of precision medicine in infectious and rare diseases, cancer, and complex diseases. Presentations and discussions concerned new technologies, bioinformatics, and new diagnostic and therapeutic approaches based on findings in basic research. Organization of precision medicine models and their implementation in medical practice at the national and international levels were also on the agenda. 29 scientists from different fields of medicine presented their work during a three-day exciting trip into the future of patient’ care. Panel discussions shed light on the development of precision medicine for better treatment of patients.

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Normark, Daniel. "Flexibility or Inexactitude? The “Lab 60” at Karolinska Institutet: From Medical Disciplines towards the Modern Biomedical Complex." Ambix 62, no. 2 (May 2015): 167–88. http://dx.doi.org/10.1179/0002698015z.00000000078.

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31

Elfhag, Kristina. "A Synthesis of Recent Research on Obesity with the Rorschach and Suggestions for the Future." Rorschachiana 31, no. 2 (January 2010): 117–42. http://dx.doi.org/10.1027/1192-5604/a000008.

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This article reviews recent research made on obesity using the Rorschach (Comprehensive System: CS) as the main assessment procedure. It focuses on the main results of a research program performed by the author within the Karolinska Institutet in Stockholm, Sweden. When we studied Rorschach characteristics related to obesity, patients demonstrated difficulties with emotions and coping with everyday demands. We found that severe obesity was associated with lower mental distress and bodily concern. In experimentations, Rorschach predicted outcomes such as eating behaviors and weight. Larger weight loss in obesity treatments was explained by physical or dependency needs for food. These aspects could be specifically altered by treatment interventions targeting hunger or eating habits. Ego dysfunctions such as distortions in perception of reality predicted smaller weight loss and indicated more profound difficulties in obesity.

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Smith, Edvard, Rula Zain, and Daniel W. Hagey. "Classification of rare diseases: The case of the ultra-and hyper-rare." Open Access Government 39, no. 1 (July 10, 2023): 22–23. http://dx.doi.org/10.56367/oag-039-10968.

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Classification of rare diseases: The case of the ultra-and hyper-rare Dr C. I. Edvard Smith, Dr Daniel W. Hagey and Dr Rula Zain, from the Karolinska Institutet in Sweden, note that there is an almost infinite number of unique diseases, contributing to the challenges with the classification of rare diseases. It was recently estimated that there are many more unique diseases than people living on this planet (Smith et al., 2022). Therefore, how do we conduct the identification and classification of ultra and hyper-rare diseases? Diseases are either common or rare. Even if most people are affected by the common ones, it is among the rare ones that the most significant number of disease entities are found. This is because there are many mechanisms underlying disease.

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Jonsson, Marijane Luistro, Louise Åberg, Walter Osika, Eva Bojner Horwitz, and Stefan Einhorn. "Temaledare: Inre och yttre hållbarhet i kristider." Socialmedicinsk tidskrift 100, no. 3 (August 30, 2023): 429–32. http://dx.doi.org/10.62607/smt.v100i3.22045.

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Intresset för forskning, utbildning och utveckling inom social hållbarhet, inte minst under kriser, fortsätter att öka. Covid-19 pandemin, kriget i Ukraina, klimatförändringarna, den minskade biologiska mångfalden och potentiella hot såsom politisk polarisering och AI påverkar området social hållbarhet. För tio år sedan etablerades ”Centrum för social hållbarhet” (CSS) på Karolinska Institutet och olika forskare med sina perspektiv på ”Socialt hållbar utveckling – fokus på empati, compassion och altruism” bidrog till ett temanummer av Socialmedicinsk tidskrift 2013. För fem år sedan gav vi också ut temanumret ”Social hållbarhet” i Socialmedicinsk tidskrift 2018, och konstaterar att området är minst lika aktuellt idag. Vi har bjudit in forskargrupper som är intresserade av social hållbarhet, och tillsammans har vi skapat ett nytt temanummer där flera bidrag handlar om yttre och inre hållbarhet i relation till kriser.

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Radkiewicz, Cecilia, Johanna Borg Bruchfeld, Caroline Weibull, Mats Lambe, Lasse H. Jakobsen, Tarec Christoffer El-Galaly, Karin E. Smedby, and Tove Wästerlid. "Sex Differences in Lymphoma Incidence and Excess Mortality By Subtype: A Comprehensive National Study." Blood 138, Supplement 1 (November 5, 2021): 2534. http://dx.doi.org/10.1182/blood-2021-146604.

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Abstract Introduction For most cancer types, cancer incidence as well as cancer-specific mortality is higher in men compared to women. The underlying reasons for this remain unclear but hypotheses include sex differences in environmental exposure to carcinogens, health-seeking behavior and biology, such as hormonal, anatomical, and molecular disparities. For lymphomas, the impact of sex seems to differ by subtype, treatment, and calendar time. For example, in Hodgkin lymphoma (HL), male sex has historically been considered an established negative prognostic factor but in contemporary studies, therapeutic advances appear to have attenuated the prognostic value of sex. In contrast, a negative impact of male sex on prognosis has become manifest during the last decades in patients with diffuse large B-cell lymphoma and follicular lymphoma, with sex differences in rituximab clearance in elderly proposed as one explanation. Previous studies have not considered the longer life expectancy of women when predicting incidence and prognosis, and comprehensive studies on the impact of sex on incidence and excess mortality in lymphomas are lacking. Therefore, we aimed to quantify and outline sex differences in lymphoma incidence and lymphoma excess mortality by subtype in a large, population-based cohort. Methods Adult patients diagnosed with lymphoma 2000-2019 were identified via the Swedish lymphoma register (>95% national coverage). Sex-specific incidence rates were computed as the number of new cancer cases per 100,000 person-years/year and age-standardized to the Swedish population in 2019 (using population counts from Statistics Sweden). Male-to-female incidence rate ratios (IRRs) with 95% confidence intervals (CIs), adjusted for age and year of diagnosis, were estimated using Poisson regression models. Sex-specific 5-year relative survival was calculated as the ratio of the observed lymphoma patient and the matched (sex, age, and calendar year) population 5-year survival and age-standardized according to the International Cancer Survival Standards. Male-to-female 5-year excess mortality rate ratios (EMRR) including 95% CIs were estimated including age and calendar year in the Poisson regression models. Results A total of 36 859 patients with lymphoma were identified during the study period. Median age for all patients was 69 (range 16-99) years. In the whole cohort there was a male predominance of 56%. Distribution of patients by sex, and male-to-female IRR and EMRR adjusted for age and year of diagnosis by major lymphoma subtype are presented in Table 1, and graphically in Figure 1. Overall, significantly higher incidence rates among men were observed for all lymphoma subtypes except marginal zone lymphoma and primary mediastinal B-cell lymphoma. The higher male-to-female IRRs remained largely stable over calendar time. For some subtypes, male-to-female IRR differed by age. For example, in HL, male and female IRs were similar up to 35 years, whereafter the male-to-female IRR increased. For both Burkitt lymphoma and Nodular lymphocyte predominant Hodgkin lymphoma the higher male-to-female IRR was most pronounced among patients under the age of 50, although incidence was higher among men of all ages for both subtypes. Regarding survival, there was a trend for higher excess mortality among men for several subtypes (Table 1, Fig 1). Significantly higher EMRRs among male patients were seen in HL, aggressive lymphomas not otherwise specified, and small lymphocytic lymphoma. Conclusion In this large population-based study we observe a significantly higher incidence rate among men for all but two lymphoma subtypes. Further, there was a trend for worse survival among male lymphoma patients for most lymphomas although only significantly worse for three subtypes, potentially due to small numbers for rare subtypes and limited adjustment. As of yet, reasons for sex differences in incidence and excess mortality of lymphoma are unknown. Better understanding of underlying factors to these differences may improve management of lymphomas and increase knowledge of lymphoma biology and etiology. Thus, further studies on sex differences in lymphoma with detailed data regarding disease-specific patient characteristics, treatment and patient-related factors such as comorbidity and socioeconomic status are warranted. Figure 1 Figure 1. Disclosures Weibull: Jansen-Cilag: Other: part of a research collaboration between Karolinska Institutet and Janssen Pharmaceutica NV for which Karolinska Institutet has received grant support. El-Galaly: Abbvie: Other: Speakers fee; ROCHE Ltd: Ended employment in the past 24 months. Smedby: Jansen-Cilag: Other: part of a research collaboration between Karolinska Institutet and Janssen Pharmaceutica NV for which Karolinska Institutet has received grant support.

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Csoma, Eszter, György Lengyel, Krisztián Bányai, Péter Takács, Noel Ánosi, Szilvia Marton, Mária Mátyus, Erika Pászti, Lajos Gergely, and Attila Szűcs. "Study of Karolinska Institutet and Washington University polyomaviruses in tonsil, adenoid, throat swab and middle ear fluid samples." Future Microbiology 13, no. 16 (December 2018): 1719–30. http://dx.doi.org/10.2217/fmb-2018-0280.

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Skjönberg, Guldbrand, Maria Isabel Gutiérrez, Reza Mohammadi, Andrés Villaveces, Barbara Minuzzo, and Shrikant I. Bangdiwala. "Professor Emeritus Dr Leif O. Svanström, MD, PhD, Karolinska Institutet, Stockholm, Sweden 30 October 1943 – 29 January 2023." International Journal of Injury Control and Safety Promotion 30, no. 2 (April 3, 2023): 321–23. http://dx.doi.org/10.1080/17457300.2023.2211874.

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Goswami, Chandan, and Md Shahidul Islam. "Transient Receptor Potential Channels: What is happening? Reflections in the wake of the 2009 TRP meeting, Karolinska Institutet, Stockholm." Channels 4, no. 2 (March 2010): 124–35. http://dx.doi.org/10.4161/chan.4.2.11478.

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Severinson, Eva, and Jurga Laurencikiene. "Regulation of epsilon germline transcription and switch region mutations by IgH locus 3′ enhancers in transgenic mice (35.3)." Journal of Immunology 178, no. 1_Supplement (April 1, 2007): S2. http://dx.doi.org/10.4049/jimmunol.178.supp.35.3.

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Abstract Germline (GL) transcription is regulated by specific promoters and Immunoglobulin heavy chain (IgH) 3′ locus enhancers and is necessary for Ig class switch recombination (CSR). We have generated different transgenic lines containing the GL epsilon promoter, switch (S)_psilon region and constant (C)_psilon region with or without the DNase I-sensitive regions (HS)3A-HS1,2 or HS3B-HS4 3′ IgH enhancer pairs. The enhancerless construct was expressed in B cells activated by interleukin (IL)-4 and cluster of differentiation (CD)40, thus resembling regulation of the endogenous gene. Both enhancer-containing transgenes efficiently increased expression in B cells and were strongly up-regulated by stimuli. In addition, S epsilon regions of the transgene containing HS3B-HS4 were mutated in activated, sorted B cells. Such mutations are known to precede CSR and are dependent on activation induced cytidine deaminase (AID). Our findings show that all elements necessary for recruitment of the recombination machinery are present in the transgene containing HS3 and HS4. These enhancers probably provide something more specific than mere increased accessibility of switch regions. We propose that transcription factors binding the enhancers help to target the recombination machinery to the switch regions. This work was supported by grants from the Swedish Research Council, the Swedish Institute and the Karolinska Institutet

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Butler Forslund, Emelie, Minh Tat Nhat Truong, Ruoli Wang, Åke Seiger, and Elena M. Gutierrez-Farewik. "A Protocol for Comprehensive Analysis of Gait in Individuals with Incomplete Spinal Cord Injury." Methods and Protocols 7, no. 3 (May 4, 2024): 39. http://dx.doi.org/10.3390/mps7030039.

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This is a protocol for comprehensive analysis of gait and affecting factors in individuals with incomplete paraplegia due to spinal cord injury (SCI). A SCI is a devastating event affecting both sensory and motor functions. Due to better care, the SCI population is changing, with a greater proportion retaining impaired ambulatory function. Optimizing ambulatory function after SCI remains challenging. To investigate factors influencing optimal ambulation, a multi-professional research project was grounded with expertise from clinical rehabilitation, neurophysiology, and biomechanical engineering from Karolinska Institutet, the Spinalis Unit at Aleris Rehab Station (Sweden’s largest center for specialized neurorehabilitation), and the Promobilia MoveAbility Lab at KTH Royal Institute of Technology. Ambulatory adults with paraplegia will be consecutively invited to participate. Muscle strength, sensitivity, and spasticity will be assessed, and energy expenditure, 3D movements, and muscle function (EMG) during gait and submaximal contractions will be analyzed. Innovative computational modeling and data-driven analyses will be performed, including the identification of clusters of similar movement patterns among the heterogeneous population and analyses that study the link between complex sensorimotor function and movement performance. These results may help optimize ambulatory function for persons with SCI and decrease the risk of secondary conditions during gait with a life-long perspective.

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Tranaeus, Ulrika, Nathan Weiss, Victor Lyberg, Martin Hagglund, Markus Waldén, Urban Johnson, Martin Asker, and Eva Skillgate. "Study protocol for a prospective cohort study identifying risk factors for sport injury in adolescent female football players: the Karolinska football Injury Cohort (KIC)." BMJ Open 12, no. 1 (January 2022): e055063. http://dx.doi.org/10.1136/bmjopen-2021-055063.

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IntroductionFootball is a popular sport among young females worldwide, but studies concerning injuries in female players are scarce compared with male players. The aim of this study is to identify risk factors for injury in adolescent female football players.Methods and analysisThe Karolinska football Injury Cohort (KIC) is an ongoing longitudinal study that will include approximately 400 female football academy players 12–19 years old in Sweden. A detailed questionnaire regarding demographics, health status, lifestyle, stress, socioeconomic factors, psychosocial factors and various football-related factors are completed at baseline and after 1 year. Clinical tests measuring strength, mobility, neuromuscular control of the lower extremity, trunk and neck are carried out at baseline. Players are followed prospectively with weekly emails regarding exposure to football and other physical activity, health issues (such as stress, recovery, etc), pain, performance and injuries via the Oslo Sports Trauma Research Center Overuse Injury Questionnaire (OSTRC-O). Players who report a substantial injury in the OSTRC-O, that is, not being able to participate in football activities, or have reduced their training volume performance to a moderate or major degree, are contacted for full injury documentation. In addition to player data, academy coaches also complete a baseline questionnaire regarding coach experience and education.Ethics and disseminationThe study was approved by the Regional Ethical Review Authority at Karolinska Institutet, Stockholm, Sweden (2016/1251-31/4). All participating players and their legal guardians give their written informed consent. The study will be reported in accordance with the Strengthening the Reporting of Observational studies in Epidemiology. The results will be published in peer-reviewed academic journals and disseminated to the Swedish football movement through stakeholders and media.

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Sedvall, Göran. "A quest for antipsychotic drug actions in the brain: Personal experiences from 50 years of neuropsychiatric research at Karolinska Institutet." Physiology & Behavior 92, no. 1-2 (September 2007): 238–44. http://dx.doi.org/10.1016/j.physbeh.2007.05.060.

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Ovesjö, M. L., and Y. Böttiger. "OC007—Assessment Of Clinical Pharmacology Skills As Part Of The New Integrated Final Exam For Medical Students At Karolinska Institutet." Clinical Therapeutics 35, no. 8 (August 2013): e3-e4. http://dx.doi.org/10.1016/j.clinthera.2013.07.008.

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Ström, C., G. Johanson, and Å. Nordenram. "Facial Injuries Due to Criminal Violence: A Retrospective Study of Hospital Attenders." Medicine, Science and the Law 32, no. 4 (October 1992): 345–53. http://dx.doi.org/10.1177/002580249203200411.

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The material comprised 222 assault victims whose injuries required attention at the Departments of Oral Surgery and Ear, Nose, and Throat diseases, the Central Hospital in Falun or corresponding departments at the Karolinska Institutet, Stockholm or the University Hospital in Huddinge. Information was obtained from patient records. One hundred and thirty-eight patients had fractures and the remainder had flesh-wounds, haematomas or swellings. The most frequent fracture site was the nasal bone followed by the jaws. Forty-one per cent of the patients in Falun and 28 per cent in Stockholm reported the assaults to the police: in Falun the proportion of women victims who reported the assault was significantly higher than those who did not. The willingness to notify the police of the violence was not influenced by the use of drugs or the seriousness of the injuries. The study showed that violence in suburban Stockholm was aggravated: one-third of the patients in the study required hospitalization compared to a quarter in a rural area.

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Alattar, Ali, Jiri Bartek, Brian HIrshman, and Clark Chen. "RADI-24. VENTRICULOMEGALY AFTER STEREOTACTIC RADIOSURGERY (SRS) FOR BRAIN METASTASES (BM): A PILOT ANALYSIS OF TWO INSTITUTIONAL EXPERIENCES." Neuro-Oncology Advances 1, Supplement_1 (August 2019): i26. http://dx.doi.org/10.1093/noajnl/vdz014.116.

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Abstract INTRODUCTION: Ventriculomegaly, or dilatation of the cerebrospinal fluid (CSF) space, occurs after whole-brain radiation (WBRT) of brain metastasis (BM) patients due to either 1) hydrocephalus or 2) cerebral atrophy from radiation-induced white matter injury. In this study, we examined whether cumulative radiation from repeat stereotactic radiosurgery (SRS) increases the risk of ventriculomegaly. METHODS: Patients were included if they underwent SRS of BM from 2007–2017 and had imaging follow-up. We examined a cohort of 214 patients treated at the University of California San Diego (1,106 BM) and a second cohort of 148 patients (1,760 BM) treated at Karolinska Institutet. Ventriculomegaly was defined according to established morphometric criteria. Patients were grouped according to the development of new ventriculomegaly at last follow-up. Demographic, clinical, and dosimetric factors were compared between groups using univariable and multivariable logistic regressions. RESULTS: In the UCSD cohort, 63 patients (29%) presented with ventriculomegaly before SRS. Of 151 remaining patients with normal ventricular size before first SRS, 30 (20%) developed new ventriculomegaly. The odds of developing ventriculomegaly increased with history of WBRT (OR 5.247, p< 0.001) and trended toward significance with a greater number of SRS treatments (OR 1.296, p=0.075). In the Karolinska cohort, the odds of developing new ventriculomegaly trended towards significance with a greater number of SRS treatments (OR 1.605, p=0.26). To test whether this trend would achieve significance in a larger sample, we repeated the analysis in the combined cohort of 362 patients. The association between number of SRS treatments and developing ventriculomegaly reached significance (OR 1.254, p=0.049). CONCLUSIONS: These pilot findings suggest that cumulative radiation from repeat stereotactic radiosurgery (SRS) potentially increases the risk of ventriculomegaly. Based on our study, a prospective study of >350 patients will be needed to further test this hypothesis.

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Hörte, Lars-Gunnar, Bjarne Jansson, and Leif Svanström. "The research group, the conference programme and academic training in safety promotion – a report of the activities at Karolinska Institutet, Sweden." International Journal of Injury Control and Safety Promotion 19, no. 3 (September 2012): 192–97. http://dx.doi.org/10.1080/17457300.2012.705302.

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Gromark, Caroline, Robert A. Harris, Ronny Wickström, AnnaCarin Horne, Maria Silverberg-Mörse, Eva Serlachius, and David Mataix-Cols. "Establishing a Pediatric Acute-Onset Neuropsychiatric Syndrome Clinic: Baseline Clinical Features of the Pediatric Acute-Onset Neuropsychiatric Syndrome Cohort at Karolinska Institutet." Journal of Child and Adolescent Psychopharmacology 29, no. 8 (October 1, 2019): 625–33. http://dx.doi.org/10.1089/cap.2018.0127.

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Gavel, Ylva. "Bringing the national interlending system into the local document supply process – a Swedish case study." Interlending & Document Supply 43, no. 2 (May 18, 2015): 104–9. http://dx.doi.org/10.1108/ilds-12-2014-0060.

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Purpose – The purpose of this paper is to describe how systems automating the local document supply process (such as integrated library systems and ILL management systems) can be integrated with systems automating regional document requesting (interlending). This is illustrated with a case study of DocFlow, an ILL management system developed in-house at Karolinska Institutet and its integration with Libris, the national interlending system in Sweden. Design/methodology/approach – The present paper describes how system integration between Libris and DocFlow was accomplished in practice. It also discusses various aspects of integration between systems offering automation of document supply. Findings – Integration between local document supply workflows and regional document request flows may involve techniques such as import of outgoing and incoming interlending requests, synchronization of status values between systems, exchange of messages between systems and quick links to the native interfaces of external systems. Practical implications – The paper brings up various aspects to consider when developing or procuring a system for the local management of ILL workflows. Originality/value – The paper may provide a deeper understanding of system integration, as it applies to the document supply process.

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ChiMón, Palma, Francisco B. Ortega, Jonatan R. Ruiz, Ilse De Bourdeaudhuij, David Martínez-Gómez, Germán Vicente-Rodriguez, Kurt Widhalm, et al. "Active Commuting and Physical Activity in Adolescents From Europe: Results From the HELENA Study." Pediatric Exercise Science 23, no. 2 (May 2011): 207–17. http://dx.doi.org/10.1123/pes.23.2.207.

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Chillón and Ruiz are with the Department of Physical Education and Sport, University of Granada, Spain. Chillón and Ward are with the Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, NC, USA. Ortega, Ruiz and Sjöström are with the Unit for Preventive Nutrition, Department of Biosciences and Nutrition, Karolinska Institutet, Sweden. Ortega and Castillo are with the Department of Medical Physiology, University of Granada, Spain. De Bourdeaudhuij is with the Department of Movement and Sport Sciences, Ghent University, Belgium. Martínez-Gómez is with the Immunonutrition Research Group, Department of Metabolism and Nutrition, ICTAN, Spanish National Research Council (CSIC), Spain. Vicente-Rodríguez and Moreno are with Growth, Exercise, Nutrition and Development (GENUD) Research Group, Universidad de Zaragoza, Spain. Widhalm is with the Department of Paediatrics, Division of Clinical Nutrition, Medical University of Vienna, Austria. Molnar is with the Deprtment of Paediatrics, Clinical Center, University of Pécs, Hungary. Gottrand is with Inserm U995, University Lille2 and CIC-9301-CH&U-Inserm, University Hospital of Lille, France. González-Gross is with the Department of Health and Human Performance, Universidad Politécnica de Madrid, Spain.

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Mora, J. Rodrigo. "Bone marrow precursors require β7 integrins to give rise to intestinal mononuclear phagocytes with tolerogenic potential (P3290)." Journal of Immunology 190, no. 1_Supplement (May 1, 2013): 136.27. http://dx.doi.org/10.4049/jimmunol.190.supp.136.27.

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Abstract Eduardo J. Villablanca 1, Jaime De Calisto 1, Patricia Torregrosa Paredes 1, 2, Barbara Cassani 1, Susanne Gabrielsson 2 & J. Rodrigo Mora 1 1 Gastrointestinal Unit, Massachusetts General Hospital & Harvard Medical School, Boston, MA; 2 Translational Immunology Unit, Karolinska Institutet, Stockholm, Sweden Intestinal mononuclear phagocytes, including dendritic cells (DC) and macrophages (MF), develop from at least two different bone marrow (BM) precursors. CD103- MF derive from lineage negative (Lin-) Ly6Chigh monocytes, whereas CD103+ DC, which metabolize vitamin A into all-trans retinoic acid (RA), derive from Lin-Ly6Clow BM precursors. However, how mononuclear phagocytes precursors are recruited to the intestinal mucosa remains unknown. Here, we show that BM Lin-Ly6Clow cells require β7 integrins to reconstitute intestinal mononuclear phagocytes and to give rise to RA-producing mesenteric lymph node DC. Interestingly, the BM contains a distinct population of α4β7+ Lin-Ly6Clow cells, which was markedly reduced in vitamin A-depleted mice. Importantly, mice lacking β7 integrins in the CD11c+ compartment showed decreased generation of antigen-specific regulatory T cells and were impaired in developing oral tolerance. Thus, BM progenitors require α4β7 to give rise to intestinal mononuclear phagocytes with tolerogenic potential.

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Prezioso, Carla, Ugo Moens, Giuseppe Oliveto, Gabriele Brazzini, Francesca Piacentini, Federica Frasca, Agnese Viscido, et al. "KI and WU Polyomavirus in Respiratory Samples of SARS-CoV-2 Infected Patients." Microorganisms 9, no. 6 (June 9, 2021): 1259. http://dx.doi.org/10.3390/microorganisms9061259.

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Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been declared a global pandemic. Our goal was to determine whether co-infections with respiratory polyomaviruses, such as Karolinska Institutet polyomavirus (KIPyV) and Washington University polyomavirus (WUPyV) occur in SARS-CoV-2 infected patients. Oropharyngeal swabs from 150 individuals, 112 symptomatic COVID-19 patients and 38 healthcare workers not infected by SARS-CoV-2, were collected from March 2020 through May 2020 and tested for KIPyV and WUPyV DNA presence. Of the 112 SARS-CoV-2 positive patients, 27 (24.1%) were co-infected with KIPyV, 5 (4.5%) were positive for WUPyV, and 3 (2.7%) were infected simultaneously by KIPyV and WUPyV. Neither KIPyV nor WUPyV DNA was detected in samples of healthcare workers. Significant correlations were found in patients co-infected with SARS-CoV-2 and KIPyV (p < 0.05) and between SARS-CoV-2 cycle threshold values and KIPyV, WUPyV and KIPyV and WUPyV concurrently detected (p < 0.05). These results suggest that KIPyV and WUPyV may behave as opportunistic respiratory pathogens. Additional investigations are needed to understand the epidemiology and the prevalence of respiratory polyomavirus in COVID-19 patients and whether KIPyV and WUPyV could potentially drive viral interference or influence disease outcomes by upregulating SARS-CoV-2 replicative potential.

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