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Academic literature on the topic 'Kd 3310'

Author: Grafiati

Published: 25 July 2024

Last updated: 31 July 2025

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Journal articles on the topic "Kd 3310"

1

Liu, Guocong. "Chemical compositions, A-glucosidase and A-amylase inhibitory activities of crude polysaccharides from the endodermis of shaddock (Citrus maxima)." Archives of Biological Sciences 64, no. 1 (2012): 71–76. http://dx.doi.org/10.2298/abs1201071l.

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The chemical composition of shaddock mainly includes polyphenols, proteins and polysaccharides. However, polysaccharides from shaddock materials have received much less consideration than polyphenols (Fellers et al., 1990). Herein the chemical compositions, ?-glucosidase and ?-amylase inhibitory activities of crude polysaccharides from the endodermis of shaddock were investigated. The exopolysaccharides (EPS) exhibited a broad and intense peak at 3300-3400 cm-1 that characterized the absorption of the hydroxyl group, and one weak C-H band at around 2941.3 cm-1 in the IR spectrum. The content o

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2

Savko, K. A., A. V. Samsonov, and A. N. Larionov. "Mesoarchean silicic volcanics of the Kursk block, Voronezh crystalline massif: composition, age and correlation with the Ukrainian shield." Доклады Академии наук 486, no. 6 (2019): 718–22. http://dx.doi.org/10.31857/s0869-56524866718-722.

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Rhyolites and basite rocks are present in the Archaean greenstone belts of the Kursk Domain (KD) of the East Sarmatia. The rhyolite age is 3122 ± 9 Ma (zircons, SIMS). A positive εNd (3122) = + 0.9 for rhyolites and their Sm-Nd model age ТNd (DM) = 3300 Ma as well as the age of the inherited zircon (3250 Ma) testifies to the participation of the more ancient crust component in the formation of rhyolite magmas. In geochemistry, rhyolites are very close to the TTG of the KD with an age 2.96-3.03 Ga. In the Middle Dnieper granite - greenstone area there are rhyolites and dacites with an age of 3.

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3

Setiawan, Budi, Yusran Dani, and Nurmaya Arofah. "Sorption Characteristics of ¹³⁷Cs and ⁹⁰Sr into Rembang and Sumedang Soils." Indonesian Journal of Chemistry 16, no. 3 (2018): 277. http://dx.doi.org/10.22146/ijc.21142.

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In order to understand the sorption behavior of 137Cs and 90Sr into soil sample from Rembang and Subang, it is important to estimate the effect of contact time, ionic strength and concentration of metal ion in the solution. For this reason, the interaction of 137Cs and 90Sr with soil sample has been examined. The study performed at trace concentration (~10-8 M) of CsCl and SrCl2, and batch method was used. NaCl has been selected as a representative of the ionic strength with 0.1; 0.5 and 1.0 M concentrations. Concentration of 10-8~10-4 M CsCl and SrCl2 were used for study the effect of Cs and

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4

Wikström, L., and H. F. Lodish. "Nonlysosomal, pre-Golgi degradation of unassembled asialoglycoprotein receptor subunits: a TLCK- and TPCK-sensitive cleavage within the ER." Journal of Cell Biology 113, no. 5 (1991): 997–1007. http://dx.doi.org/10.1083/jcb.113.5.997.

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The human asialoglycoprotein receptor subunit H2a is cotranslationally inserted into the ER membrane. When expressed together with subunit H1 in mouse fibroblasts part forms a hetero-oligomer that is transported to the cell surface, but when expressed alone it is all rapidly degraded. Degradation is insensitive to lysosomotropic agents and the undegraded precursor is last detected in the ER region of the cell. Small amounts of an intermediate 35-kD degradation product can be detected (Amara, J. F., G. Lederkremer, and H. F. Lodish. 1989. J. Cell Biol. 109:3315). We show here that the oligosacc

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5

Gong, Xueqian, Hong Gao, Mark H. Bender, et al. "Abstract 3316: LY3962673, an oral, highly potent, mutant-selective, and non-covalent KRAS G12D inhibitor demonstrates robust anti-tumor activity in KRAS G12D models." Cancer Research 84, no. 6_Supplement (2024): 3316. http://dx.doi.org/10.1158/1538-7445.am2024-3316.

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Abstract KRAS G12D mutations are activating oncogenic events that occur in approximately 35%, 13%, and 4% of pancreatic, colorectal, and non-small cell lung cancers, respectively, and less commonly in other cancers. We previously demonstrated that LY3962673 is a highly potent inhibitor of KRAS G12D and is selective against wild-type (WT) KRAS in mutant -cell lines and -in vivo models. Here, we describe the mechanism by which LY3962673 inhibits KRAS G12D and report a more comprehensive evaluation of LY3962673 activity across a panel of genetically and histologically diverse cancer cell lines, a

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6

Martin, Thomas, Joseph Mikhael, Roman Hajek, et al. "Depth of Response and Response Kinetics of Isatuximab Plus Carfilzomib and Dexamethasone in Relapsed Multiple Myeloma: Ikema Interim Analysis." Blood 136, Supplement 1 (2020): 7–8. http://dx.doi.org/10.1182/blood-2020-137681.

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Introduction: Achievement of minimal residual disease negative (MRD-) status in multiple myeloma (MM) is associated with improved progression-free survival (PFS) and overall survival (OS). Isatuximab (Isa) is an approved anti-CD38 IgG kappa monoclonal antibody. We analyzed the depth of response including MRD-, long-term outcomes, and kinetics of tumor response in the IKEMA study. Measurement by mass spectrometry of serum M-protein was also performed to overcome the interference with Isa in standard immunofixation assay. Methods: IKEMA was a randomized, open-label, multicenter Phase 3 study tha

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Rodriguez, Cesar, Aurore Perrot, Paul G. Richardson, et al. "The Impact of Isatuximab Regimens on Hypogammaglobulinemia Occurrence, Recovery, and Associated Infections in Patients with Relapsed/Refractory Multiple Myeloma." Blood 142, Supplement 1 (2023): 1980. http://dx.doi.org/10.1182/blood-2023-179925.

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Introduction: Isatuximab (Isa) is an immunoglobulin (Ig)G1 monoclonal antibody targeting a CD38 transmembrane glycoprotein in multiple myeloma (MM). Isa is approved for use in multiple countries to treat adults with relapsed/refractory MM (RRMM) when given in combination with either pomalidomide-dexamethasone (Pd) or carfilzomib-dexamethasone (Kd). Hypogammaglobulinemia (HGG; polyclonal IgG &lt;4 g/L) and the associated infection risk is a potential complication for patients (pts) with MM treated with immunotherapies. High infection and HGG rates have been reported during treatment (tx) wi

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8

BECKINGHAM, Jennifer A., Nicholas G. HOUSDEN, Nicola M. MUIR, Stephen P. BOTTOMLEY, and Michael G. GORE. "Studies on a single immunoglobulin-binding domain of protein L from Peptostreptococcus magnus: the role of tyrosine-53 in the reaction with human IgG." Biochemical Journal 353, no. 2 (2001): 395–401. http://dx.doi.org/10.1042/bj3530395.

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Chemical modification experiments with tetranitromethane (TNM) have been used to investigate the role of tyrosine residues in the formation of the complex between PpL (the single Ig-binding domain of protein L, isolated from P. magnus strain 3316) and the kappa light chain (κ-chain). Reaction of PpL with TNM causes the modification of 1.9 equiv. of tyrosine (Tyr51 and Tyr53) and results in an approx. 140-fold decrease in affinity for human IgG. Similar experiments with mutated PpL proteins suggest that nitration predominantly inactivates the protein by modification of Tyr53. Reduction of the n

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9

Shang, Erchang, Boyu Zhong, Tony Zhang, et al. "Abstract 3315: Preclinical studies of TSN1611, a potent, selective, and orally bioavailable KRASG12D inhibitor." Cancer Research 84, no. 6_Supplement (2024): 3315. http://dx.doi.org/10.1158/1538-7445.am2024-3315.

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Abstract Background: KRAS mutations are the most frequently encountered driver oncogene, involved in ~25% of all human cancers [1,2]. KRASG12D is the predominant KRAS mutation isoform, detected in approximately 35% of pancreatic cancer, 13% of colorectal cancer, and 5% of NSCLC [3]. Compared to KRASG12C, targeting KRASG12D has proven to be more challenging since the target protein lacks a reactive amino acid residue for irreversible inhibitory modification by a ligand. Herein, we disclose TSN1611, a potent and selective KRASG12D inhibitor, which possesses favorable oral PK profiles and demonst

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10

Trieu, V. N., and W. J. McConathy. "The binding of animal low-density lipoproteins to human apolipoprotein(a)." Biochemical Journal 309, no. 3 (1995): 899–904. http://dx.doi.org/10.1042/bj3090899.

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Lipoprotein(a) [Lp(a)] is a risk factor for coronary artery disease. It is composed of lipids and apolipoprotein(a) [apo(a)] linked to apolipoprotein B (apoB) by a disulphide bond between Cys-4057 of apo(a)'s kringle 36 and possibly Cys-3734 of apoB. We call this the covalent apo(a): apoB-Lp interaction, to distinguish it from the non-covalent apo(a)/Lp(a): apoB-Lp interaction, which is probably mediated by apo(a)'s kringle 33 and residues 3304-3317 of apoB. The non-covalent interaction could be the initial interaction which brings apo(a) and apoB together prior to covalent linkage and Lp(a) f

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Books on the topic "Kd 3310"

1

Obligation, Entitlement and Dispute under the English Poor Laws. Cambridge Scholars Publishing, 2015.

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Reports on the topic "Kd 3310"

1

Loebenstein, Gad, William Dawson, and Abed Gera. Association of the IVR Gene with Virus Localization and Resistance. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7604922.bard.

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We have reported that localization of TMV in tobacco cultivars with the N gene, is associated with a 23 K protein (IVR) that inhibited replication of several plant viruses. This protein was also found in induced resistant tissue of Nicotiana glutinosa x Nicotiana debneyi. During the present grant we found that TMV production is enhanced in protoplasts and plants of local lesion responding tobacco cultivars exposed to 35oC, parallel to an almost complete suppression of the production of IVR. We also found that IVR is associated with resistance mechanisms in pepper cultivars. We succeeded to clo

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