Relevant bibliographies by topics / KDMs

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'KDMs'

Author: Grafiati
Published: 10 March 2023
Last updated: 31 July 2025

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Journal articles on the topic "KDMs"

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Dorna, Dawid, and Jarosław Paluszczak. "The Emerging Significance of Histone Lysine Demethylases as Prognostic Markers and Therapeutic Targets in Head and Neck Cancers." Cells 11, no. 6 (2022): 1023. http://dx.doi.org/10.3390/cells11061023.

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Epigenetic aberrations, associated with altered DNA methylation profiles and global changes in the level of histone modifications, are commonly detected in head and neck squamous cell carcinomas (HNSCC). Recently, histone lysine demethylases have been implicated in the pathogenesis of HNSCC and emerged as potential molecular targets. Histone lysine demethylases (KDMs) catalyze the removal of methyl groups from lysine residues in histones. By affecting the methylation of H3K4, H3K9, H3K27, or H3K36, these enzymes take part in transcriptional regulation, which may result in changes in the level
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Vicioso-Mantis, Marta, Samuel Aguirre, and Marian A. Martínez-Balbás. "JmjC Family of Histone Demethylases Form Nuclear Condensates." International Journal of Molecular Sciences 23, no. 14 (2022): 7664. http://dx.doi.org/10.3390/ijms23147664.

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The Jumonji-C (JmjC) family of lysine demethylases (KDMs) (JMJC-KDMs) plays an essential role in controlling gene expression and chromatin structure. In most cases, their function has been attributed to the demethylase activity. However, accumulating evidence demonstrates that these proteins play roles distinct from histone demethylation. This raises the possibility that they might share domains that contribute to their functional outcome. Here, we show that the JMJC-KDMs contain low-complexity domains and intrinsically disordered regions (IDR), which in some cases reached 70% of the protein.
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Wigle, Tim J., Kerren K. Swinger, John E. Campbell, et al. "A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase Screening." Journal of Biomolecular Screening 20, no. 6 (2015): 810–20. http://dx.doi.org/10.1177/1087057115575689.

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Demethylation of histones by lysine demethylases (KDMs) plays a critical role in controlling gene transcription. Aberrant demethylation may play a causal role in diseases such as cancer. Despite the biological significance of these enzymes, there are limited assay technologies for study of KDMs and few quality chemical probes available to interrogate their biology. In this report, we demonstrate the utility of self-assembled monolayer desorption/ionization (SAMDI) mass spectrometry for the investigation of quantitative KDM enzyme kinetics and for high-throughput screening for KDM inhibitors. S
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Bonnici, Joanna, Anthony Tumber, Akane Kawamura, and Christopher J. Schofield. "Inhibitors of both the N -methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases." Philosophical Transactions of the Royal Society B: Biological Sciences 373, no. 1748 (2018): 20170071. http://dx.doi.org/10.1098/rstb.2017.0071.

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The Jumonji C (JmjC) family of 2-oxoglutarate (2OG)-dependent oxygenases have established roles in the regulation of transcription via the catalysis of demethylation of N ε - methylated lysine residues in histone tails, especially the N - terminal tail of histone H3. Most human JmjC N ɛ -methyl lysine demethylases (KDMs) are complex enzymes, with ‘reader domains’ in addition to their catalytic domains. Recent biochemical evidence has shown that some, but not all, JmjC KDMs also have N ω - methyl arginyl demethylase (RDM) activity. JmjC KDM activity has been linked to multiple cancers and some
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Kim, Yoon-Jung, Dong Hoon Lee, Yong-Sung Choi, Jin-Hyun Jeong, and So Hee Kwon. "Benzo[b]tellurophenes as a Potential Histone H3 Lysine 9 Demethylase (KDM4) Inhibitor." International Journal of Molecular Sciences 20, no. 23 (2019): 5908. http://dx.doi.org/10.3390/ijms20235908.

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Gene expression and tumor growth can be regulated by methylation levels of lysine residues on histones, which are controlled by histone lysine demethylases (KDMs). Series of benzo[b]tellurophene and benzo[b]selenophene compounds were designed and synthesized and they were evaluated for histone H3 lysine 9 demethylase (KDM4) inhibitory activity. Among the carbamates, alcohol and aromatic derivatives, tert-butyl benzo[b]tellurophen-2-ylmethylcarbamate (compound 1c) revealed KDM4 specific inhibitory activity in cervical cancer HeLa cells, whereas the corresponding selenium or oxygen substitute co
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Guo, Xiaoqiang, and Qiaoxia Zhang. "The emerging role of histone demethylases in renal cell carcinoma." Journal of Kidney Cancer and VHL 4, no. 2 (2017): 1–5. http://dx.doi.org/10.15586/jkcvhl.2017.56.

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Renal cell carcinoma (RCC), the most common kidney cancer, is responsible for more than 100,000 deaths per year worldwide. The molecular mechanism of RCC is poorly understood. Many studies have indicated that epigenetic changes such as DNA methylation, noncoding RNAs, and histone modifications are central to the pathogenesis of cancer. Histone demethylases (KDMs) play a central role in histone modifications. There is emerging evidence that KDMs such as KDM3A, KDM5C, KDM6A, and KDM6B play important roles in RCC. The available literature suggests that KDMs could promote RCC development and progr
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Wang, Zhanxin, and Dinshaw J. Patel. "Small molecule epigenetic inhibitors targeted to histone lysine methyltransferases and demethylases." Quarterly Reviews of Biophysics 46, no. 4 (2013): 349–73. http://dx.doi.org/10.1017/s0033583513000085.

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AbstractAltered chromatin structures and dynamics are responsible for a range of human malignancies, among which the status of histone lysine methylation remains of paramount importance. Histone lysine methylation is maintained by the relative activities of sequence-specific methyltransferase (KMT) writers and demethylase (KDM) erasers, with aberrant enzymatic activities or expression profiles closely correlated with multiple human diseases. Hence, targeting these epigenetic enzymes should provide a promising avenue for pharmacological intervention of aberrantly marked sites within the epigeno
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Hanauske-Abel, Hartmut Martin, Mainul Hoque, Seema Husain, Sukhwinder Singh, Axel R. Hanauske, and Patricia Soteropoulos. "Abstract 2722: An added twist: drug-mediated pan-inhibition of KDM catalysis causes selective reduction of mRNAs that encode a small subset of KDM enzymes." Cancer Research 85, no. 8_Supplement_1 (2025): 2722. https://doi.org/10.1158/1538-7445.am2025-2722.

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Abstract Background: The class of 2-oxoglutarate-requiring mono-iron dioxygenases (MIDOs) that demethylate specific lysine, histidine, or arginine residues of histones is receiving attention for its role in human diseases, in particular cancer (10.1016/j.ejmech.2022.114143). The steric events during MIDO catalysis were resolved at subatomic scale in 1982 by two students at Philipps University, Marburg/Germany (HAG mechanism [10.1016/0022-5193(82)90320-4, 10.1016/0022-5193(82)90320-4]). They presented a classification of all conceivable inhibitors and rapidly reduced their seminal approach to p
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Nic-Can, Geovanny I., Beatriz A. Rodas-Junco, Leydi M. Carrillo-Cocom, et al. "Epigenetic Regulation of Adipogenic Differentiation by Histone Lysine Demethylation." International Journal of Molecular Sciences 20, no. 16 (2019): 3918. http://dx.doi.org/10.3390/ijms20163918.

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Obesity is a rising public health problem that contributes to the development of several metabolic diseases and cancer. Adipocyte precursors outside of adipose depots that expand due to overweight and obesity may have a negative impact on human health. Determining how progenitor cells acquire a preadipocyte commitment and become mature adipocytes remains a significant challenge. Over the past several years, we have learned that the establishment of cellular identity is widely influenced by changes in histone marks, which in turn modulate chromatin structure. In this regard, histone lysine deme
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Nanduri, Jayasri, Ning Wang, Benjamin L. Wang та Nanduri R. Prabhakar. "Lysine demethylase KDM6B regulates HIF-1α-mediated systemic and cellular responses to intermittent hypoxia". Physiological Genomics 53, № 9 (2021): 385–94. http://dx.doi.org/10.1152/physiolgenomics.00045.2021.

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Intermittent hypoxia (IH) is a hallmark manifestation of obstructive sleep apnea (OSA). Rodents treated with IH exhibit hypertension. Hypoxia-inducible factor (HIF)-1-dependent transcriptional activation of NADPH oxidases ( Nox) and the resulting increase in reactive oxygen species (ROS) levels is a major molecular mechanism underlying IH/OSA-induced hypertension. Jumanji C (JmjC)-containing histone lysine demethylases (JmjC-KDMs) are coactivators of HIF-1-dependent transcriptional activation. In the present study, we tested the hypothesis that JmjC-KDMs are required for IH-evoked HIF-1 transc
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Dissertations / Theses on the topic "KDMs"

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Balzano, Amodio Luca. "Design, synthesis, biological evaluation and binding studies of new small-molecule modulators of KDMs (lysine-specific demethylases)." Doctoral thesis, Universita degli studi di Salerno, 2017. http://hdl.handle.net/10556/2419.

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2014 - 2015<br>JHDMs (JmjC-domain-containing histone demethylases) are the largest class of demethylase enzymes, contain a Jumonji C (JmjC) domain and catalyze lysine demethylation of histones through an oxidative reaction that requires Fe(II) ion and α-ketoglutarate (2OG) as cofactors. The misregulation of these enzymes, in particular JMJD2 subfamily, has being significantly implicated in cancer initiation and progression. Potent and specific inhibitors of these enzymes have not been identified yet, most of them inhibiting many other Fe(II)/2OG dependent oxygenases or being affected by undesi
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Schiller, Rachel Shamo. "Investigating the inhibitor and substrate diversity of the JmjC histone demethylases." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:1e7fd2a1-a9c3-48f7-8fa7-a041299d42f9.

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Epigenetic control of gene expression by histone post-translational modifications (PTMs) is a complex process regulated by proteins that can 'read', 'write' or 'erase' these PTMs. The histone lysine demethylase (KDM) family of epigenetic enzymes remove methyl modifications from lysines on histone tails. The Jumonji C domain (JmjC) family is the largest family of KDMs. Investigating the scope and mechanisms of the JmjC KDMs is of interest for understanding the diverse functions of the JmjC KDMs in vivo, as well as for the application of the basic science to medicinal chemistry design. The work
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Hookway, Edward. "The role of the lysine demethylases KDM5 and KDM6 in bone malignancies." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:b591861f-985b-4722-8027-492e750f3ff7.

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Methylation of histone lysine residues functions as a dynamic, reversible mechanism for regulating gene expression and aberrations in this process have been linked with the development of cancer. Members of the lysine demethylase (KDM) family remove methyl marks from histones. KDM5B removes methyl marks from histone H3 lysine 4 (H3K4) whereas KDM6A and KDM6B remove methyl marks from histone H3 lysine 27 (H3K27). In this thesis, GSK-J4, an inhibitor of KDM5B, KDM6A and KDM6B, is shown to impair viability in a range of cancers affecting bone including multiple myeloma, Ewing sarcoma and chordoma
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Chen, Runqiu, and 陳潤球. "Statistical validation of kidney deficiency syndromes (KDS) and the development of a KDS questionnaire in Hong Kong Chinese women aged 40-60 years." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43223813.

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Chen, Runqiu. "Statistical validation of kidney deficiency syndromes (KDS) and the development of a KDS questionnaire in Hong Kong Chinese women aged 40-60 years." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43223813.

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Ådahl, Hanna, and My Brännström. "The naked truth? : En kritisk diskursanalys om fast fashion-företaget NA-KD:s externa kommunikation." Thesis, Umeå universitet, Institutionen för kultur- och medievetenskaper, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-179312.

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The purpose of this study was to increase the understanding of how the Swedish fast fashion company NA-KD expressed its profile and how it could be linked to sustainability. The fashion industry is known for having big sustainability problems, and that is why the main focus of this study was the paradox between fast fashion and sustainability due to its conflict nature. To concretise the aim of the study, we formulated two questions: “What discourses can be found in NA-KD’s external communication?” and “What profile does the company express through their website?”. To analyse the company’s web
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Khin, Khin Nyo Aree Jampaklay. "Access to health utilization among people aged 50 and older in KDSS is it equal /." Abstract, 2007. http://mulinet3.li.mahidol.ac.th/thesis/2550/cd404/4938533.pdf.

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Autaa, Julie. "The role of the histone demethylase Kdm3 complex in defining the boundaries of piRNA clusters." Electronic Thesis or Diss., Sorbonne université, 2024. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2024SORUS234.pdf.

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Pour préserver l'intégrité du génome de la lignée germinale animale, l'activité des éléments transposables (TE) est régulée par de petits ARN non codants appelés ARN piwi-interacting (piRNAs). Dans les ovaires de Drosophila melanogaster, les piRNAs proviennent de régions hétérochromatiques appelées piRNA clusters. Ces régions présentent un enrichissement en séquences incomplètes de TE et des marques de di- ou tri-méthylation de la lysine 9 sur l'histone 3 (H3K9me2/3), caractéristiques de l'hétérochromatine. Malgré une chromatine condensée, la transcription se produit dans ces régions, facilité
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Bader, Caroline, Eva-Louise Castefelt, and Louise Gunnarsson. "Influencers Marketing : En fallstudie om NA-KDs nyckel till en god tillväxt." Thesis, Högskolan i Borås, Akademin för textil, teknik och ekonomi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-15381.

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Begreppet influencer blir mer och mer välkänt för varje dag. Begreppet syftar till ett yrke som vuxit fram i takt med internet. Även om det finns mycket information att tillgå kring fenomenet finns det många aspekter som fortfarande icke blivit belysta. Den information som finns att tillgå kring ämnet är inte heller i vetenskaplig tappning. Syftet med studien är att analysera och redogöra för hur influencer marketing kan påverka tillväxten för ett företag. Härtill studeras influencers inverkan på varumärkesbyggandet i relation till tillväxt. Följande kommer en fallstudie i samarbete med klädfö
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Tingare, Asmita. "The role of the KDM4 family histone 3 lysine 9 demethylases in hypertrophic remodelling of cardiac myocytes." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648522.

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Books on the topic "KDMs"

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Solakov, Angel. Predsedateli͡a︡t na KDS razkazva--. "Teksimreklama" AD, 1993.

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Nussbaum, Debra. KDES curriculum guide for auditory and speech training. 2nd ed. Pre-College Programs, Gallaudet University, 1988.

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Sanders, Addie Meyer. Alligators under the bed: PMZ 4 KDS. [Sanders, 1990.

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Kitingan, Jeffrey G. Masa depan masyarakat Kadazandusun dan Murut (KDM): Kemanakah arah kita dari sini? Koisaan Cultural Development Institute, 1997.

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Seminar on Petroliferous Basins of India (2nd 1991 KDM Institute of Petroleum Exploration). Proceedings of the Second Seminar on Petroliferous Basins of India, 18-20 December 1991, KDM Institute of Petroleum Exploration, ONGC, Dehra Dun. Edited by Biswas, S. K. (Sanjib Kumar), 1935- and Keshava Deva Malaviya Institute of Petroleum Exploration. Indian Petroleum Publishers, 1993.

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Kyritz, Heinz. Wenn Ein Engel Kdme. Authorhouse, 2004.

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Limar, Natalia Smirnova. Prüfungstraining KDS - Grammatikteil. GRIN Verlag GmbH, 2010.

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Kūle, Maija, ed. Kritiskā domāšana: izglītība, medijpratība, spriestspēja. LU Filozofijas un socioloģijas institūts, 2018. http://dx.doi.org/10.22364/kdims.

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Giblin, James Cross, and Eileen Christelow. JEROME+WITCHCRAFT KDS PA. Clarion Books, 1990.

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Ze studně večera kdos něžný vážil krev. Albert, 2009.

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Book chapters on the topic "KDMs"

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McLaughlin-Drubin, Margaret. "KDM6." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27841-9_7177-3.

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McLaughlin-Drubin, Margaret. "KDM6." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-46875-3_7177.

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Jiang, Yuanyuan, Lanxin Liu, and Zeng-Quan Yang. "KDM4 Demethylases: Structure, Function, and Inhibitors." In Targeting Lysine Demethylases in Cancer and Other Human Diseases. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-38176-8_5.

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Knechtli, Hanspeter. "Kantonale Drucksachen- und Materialzentrale Zürich (kdmz)." In E-Business-Integration. Carl Hanser Verlag GmbH & Co. KG, 2003. http://dx.doi.org/10.3139/9783446226432.004.

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Naor, Moni, Benny Pinkas, and Omer Reingold. "Distributed Pseudo-random Functions and KDCs." In Advances in Cryptology — EUROCRYPT ’99. Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/3-540-48910-x_23.

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Gaži, Peter, and Stefano Tessaro. "Provably Robust Sponge-Based PRNGs and KDFs." In Advances in Cryptology – EUROCRYPT 2016. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-49890-3_4.

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Shao, Peng, Qi Liu, and Hank Heng Qi. "KDM7 Demethylases: Regulation, Function and Therapeutic Targeting." In Targeting Lysine Demethylases in Cancer and Other Human Diseases. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-38176-8_8.

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Waters, Brent, and Daniel Wichs. "Universal Amplification of KDM Security: From 1-Key Circular to Multi-Key KDM." In Advances in Cryptology – CRYPTO 2023. Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-38545-2_22.

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Davies, Gareth T., and Martijn Stam. "KDM Security in the Hybrid Framework." In Topics in Cryptology – CT-RSA 2014. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-04852-9_24.

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Chang, Jinyong, Honglong Dai, and Maozhi Xu. "The KDM-CCA Security of REACT." In Information Security Practice and Experience. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-72359-4_5.

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Conference papers on the topic "KDMs"

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Trinh, Quoc-Huy, Minh-Van Nguyen, and Phuoc-Thao Vo Thi. "KDAS: Knowledge Distillation via Attention Supervision Framework for Polyp Segmentation." In 2024 IEEE International Conference on Multimedia and Expo (ICME). IEEE, 2024. http://dx.doi.org/10.1109/icme57554.2024.10687662.

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TSENG, CHIA YAN, SHIA CHUNG CHEN, WEN REN JONG, and YUNG HSIANG CHANG. "Knowledge Based Deriven Manufacturing System KDMS for Injection Molding." In Second International Conference on Advances in Mechanical and Automation Engineering - MAE 2015. Institute of Research Engineers and Doctors, 2015. http://dx.doi.org/10.15224/978-1-63248-045-3-40.

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Lee, Tai Sik, Dong Wook Lee, and Sang Bok Jee. "Development of Knowledge Document Management System (KDMS) for Sharing Construction Technical Documents." In Construction Research Congress 2005. American Society of Civil Engineers, 2005. http://dx.doi.org/10.1061/40754(183)115.

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Khalefa, Mohamed E., and Sameh S. El-Atawy. "Demonstrating KDBMS." In SSDBM '16: Conference on Scientific and Statistical Database Management. ACM, 2016. http://dx.doi.org/10.1145/2949689.2949714.

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Ohanian, Vigen, Thomas M. Snyder, and Ananda Gunawardena. "Analytic properties of thef‐kDMO operator." In SEG Technical Program Expanded Abstracts 1993. Society of Exploration Geophysicists, 1993. http://dx.doi.org/10.1190/1.1822315.

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Marvian, Abbas, Olivier Point, and Trond Inge Ramsnes. "CCS-TCA, An Analytical Tool for CCS Technology and Concept Assessment." In SPE Europe Energy Conference and Exhibition. SPE, 2025. https://doi.org/10.2118/225492-ms.

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Abstract Development of Carbon Capture and Storage (CCS) projects requires meticulous planning, strategic preparation, institutional frameworks, rigorous technical analysis, and specialized human resources. To support decision-making process in CCS projects, an Excel-based model is developed. The objective of the model is to provide a systematic and quantitative framework for evaluating and selecting the most appropriate solutions for deployment of facilities within the CCS value chain. By leveraging the decision gate process commonly employed in the oil and gas- energy industries, CCS project
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Yi Yang, Tao Zheng, and Xin Lin. "A KDSS for green dyeing and printing management." In 2010 International Conference on Computer Design and Applications (ICCDA 2010). IEEE, 2010. http://dx.doi.org/10.1109/iccda.2010.5541512.

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Pérez-Castillo, Ricardo, Ignacio García-Rodríguez de Guzmán, Mario Piattini, and Barbara Weber. "Integrating event logs into KDM repositories." In the 27th Annual ACM Symposium. ACM Press, 2012. http://dx.doi.org/10.1145/2245276.2231949.

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Kadar, Manuella, and Adrian Tulbure. "An automated knowledge discovery framework with multi-agent systems — KDMAS." In 2017 International Conference on Engineering, Technology and Innovation (ICE/ITMC). IEEE, 2017. http://dx.doi.org/10.1109/ice.2017.8280025.

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Maurer, Jochen. "Abstract 155: KDM4 inhibition targets breast cancer stem-like cells." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-155.

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Reports on the topic "KDMs"

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บัวบูชา, ธีรพงษ์, ศุภอรรจ ศิริกันทรมาศ та นุชนาถ วุฒิประดิษฐกุล. การค้นหายีนที่ควบคุมโดยโปรตีนคัลมอดุลินในการตอบสนองต่อสภาวะความเครียดจากสิ่งแวดล้อมของข้าว Oryza sativa L. : รายงานวิจัย. จุฬาลงกรณ์มหาวิทยาลัย, 2014. https://doi.org/10.58837/chula.res.2014.59.

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Environmental stresses such as salinity, drought, heat, or pathogen greatly affect agricultural productivity. Researchers have long been attempting to improve plant tolerance to these adverse conditions. To be successful, knowledge of the mechanisms involved in environmental stress responses of plants in the molecular level is needed. To tolerate stress in plants, Ca2+ signals have been implicated in transducing the initial signals from various environmental changes to elicit appropriate responses. Here, we aimed to identify genes that are regulated by OsCaM1, which is a primary Ca2+ sensor ca
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