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Rajasimha, Harsha Karur. "PathMeld: A Methodology for The Unification of Metabolic Pathway Databases." Thesis, Virginia Tech, 2004. http://hdl.handle.net/10919/36325.
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A biological pathway database is a database that describes biochemical pathways, reactions, enzymes that catalyze the reactions, and the substrates that participate in these reactions. A pathway genome database (PGDB) integrates pathway information with information about the complete genome of various sequenced organisms. Two of the popular PGDBs available today are the Kyoto Encyclopedia of Genes and Genomes (KEGG) and MetaCyc. The proliferation of biological databases in general raises several questions for the life scientist. Which of these databases is most accurate, most current, or most comprehensive? Do they have a standard format? Do they complement each other? Overall, which database should be used for what purpose? If more than one database is deemed relevant, it is desirable to have a unified database containing information from all the shortlisted databases. There is no standard methodology yet for integrating biological pathway databases and, to the best of our knowledge, no commercial software that can perform such integration tasks. While XML based pathway data exchange standards such as BioPAX and SBML are emerging, these do not address the basic problems such as inconsistent nomenclature and substrate matching between databases in the unification of pathway databases.
Here, we present the PathMeld methodology to unify KEGG and MetaCyc databases starting from their flat files. Individual PGDBs are transformed into a unified schema that we design. With individual PGDBs in the common unified schema, the key to the PathMeld methodology is to find the entity correspondences between the KEGG and MetaCyc substrates. We present a heuristic driven approach for one-to-one mapping of the substrates between KEGG and MetaCyc. Using the exact name and chemical formula match criteria, 82.6% of the substrates in MetaCyc were matched accurately to corresponding substrates in KEGG. The substrate names in the MetaCyc database contain html tags and non-characters such as , , , Master of Science
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Johnson, Stephen Robert. "iPathCase." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1327935542.
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守屋, 勇樹. "ゲノムからのパスウェイ推定の為のバイオインフォマティクス研究." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225302.
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Aloraini, Adel Abdullah M. "Extending the graphical representation of four KEGG pathways for a better understanding of prostate cancer using machine learning of graphical models." Thesis, University of York, 2011. http://etheses.whiterose.ac.uk/1711/.
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This thesis shows a novel contribution to computational biology alongside with developed machine learning methods. It shows how the graphical representation of KEGG pathways can be refined using machine learning of graphical models. The focus mainly is on a set of graphical models called Bayesian networks. Throughout this thesis , different ways of learning Bayesian networks are discussed. The work is based on Affymetrix gene expression microarray profiles and penalised Gaussian linear models. Penalisation in linear models includes choosing the most important parents and estimating the associated coefficients simultaneously using L1-regression. The sparse dataset that is generated from Affymetrix microarray technology is the key point in this thesis when learning Bayesian networks. Thus, the work in this thesis can be viewed as developing robust methods to avoid overfitting that usually associated with gene expression datasets and contributing to invoke more details about a well known discrepancy in KEGG pathways. So,the problem we have is to learn from a large number of candidates, small samples,(p>>n), and for such problem the goal is to apply model selection methods that hopefully achieve an accurate prediction , interpretable models, and stable models. The prediction and the most powerful predictors can be improved by using methods that trade-off between bias and variance. Also, providing which predictors are meaningful rather than using all predictors will provide interpretable models, and finally by choosing the most important predictors, a small change in the data will not result in large changes in the subset of predictors which consequently gives the stability to the models that are learnt.
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Csombordi, Rajmund. "Metabolomics database resolver." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-417525.
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Metabolomics is a rising field combining bioinformatics and cheminformatics together. A major component of research is having a reliable data source, which usually comes in the form of metabolomic databases. This paper documents arising issues revolving categorizing metabolome compounds within databases, and a possible solution in the form of an R package that is capable of matching up various metabolome identifiers that originate from various metabolome databases. Then, by using this package we reflect on the average coverage of external reference between metabolome databases to highlight the lack of a universal compound primary identifier.The thesis presentation was held over Zoom due to the recent COVID19 pandemic.
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Ganesan, Sukirth M. "Relative Contributions Of Tobacco Associated Factors And Diabetes To Shaping The Oral Microbiome." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1529572658170786.
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Cheung, Ka-wing, and 張嘉穎. "Spatial and seasonal variations of freshwater macroinvertebrates, odonata and waterbirds in Luk Keng marshland, Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41290951.
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Tam, Tat-kuen. "Geology of Tiu Keng Leng new development area." View the Table of Contents & Abstract, 2001. http://sunzi.lib.hku.hk/hkuto/record/B30109243.
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Tam, Tat-kuen, and 譚達權. "Geology of Tiu Keng Leng new development area." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B4389463X.
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Isik, Zerrin, Tulin Ersahin, Volkan Atalay, Cevdet Aykanat, and Rengul Cetin-Atalay. "A signal transduction score flow algorithm for cyclic cellular pathway analysis, which combines transcriptome and ChIP-seq data." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-138982.
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Determination of cell signalling behaviour is crucial for understanding the physiological response to a specific stimulus or drug treatment. Current approaches for large-scale data analysis do not effectively incorporate critical topological information provided by the signalling network. We herein describe a novel model- and data-driven hybrid approach, or signal transduction score flow algorithm, which allows quantitative visualization of cyclic cell signalling pathways that lead to ultimate cell responses such as survival, migration or death. This score flow algorithm translates signalling pathways as a directed graph and maps experimental data, including negative and positive feedbacks, onto gene nodes as scores, which then computationally traverse the signalling pathway until a pre-defined biological target response is attained. Initially, experimental data-driven enrichment scores of the genes were computed in a pathway, then a heuristic approach was applied using the gene score partition as a solution for protein node stoichiometry during dynamic scoring of the pathway of interest. Incorporation of a score partition during the signal flow and cyclic feedback loops in the signalling pathway significantly improves the usefulness of this model, as compared to other approaches. Evaluation of the score flow algorithm using both transcriptome and ChIP-seq data-generated signalling pathways showed good correlation with expected cellular behaviour on both KEGG and manually generated pathways. Implementation of the algorithm as a Cytoscape plug-in allows interactive visualization and analysis of KEGG pathways as well as user-generated and curated Cytoscape pathways. Moreover, the algorithm accurately predicts gene-level and global impacts of single or multiple in silico gene knockoutsDieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich
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Broderick, Shaun Robert. "Pollination-Induced Gene Changes That Lead to Senescence in Petunia × hybrida." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1408958432.
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Lan, On-wai Kenneth. "Rennie's Mill the origin and evolution of a special enclave in Hong Kong /." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36777766.
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Munda, Bruce David 1953. "Germination characteristics of two yellow bluestems, Bothriochloa ischaemum (L.) Keng." Thesis, The University of Arizona, 1993. http://hdl.handle.net/10150/278306.
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Germination responses of P.I. 237110 and 'Ganada' yellow bluestem (Bothriochloa ischaemum (L.) Keng.) were compared in four experiments. P.I. 237110 had the highest total germination for all seed conditioning treatments. At the lowest temperature (15.6°C) P.I. 237110 did not germinate and Ganada had a low total germination. P.I. 237110 and Ganada require high (>20°C) incubation temperatures for optimum germination. Seed conditioning treatments did not significantly increase total germination for P.I. 237110 or Ganada. The caryopsis treatment gave the highest percent germination for all germplasm except Ganada. P.I. 237110 had the fastest time to 50% germination for all seed conditioning treatments. Seed conditioning did not significantly affect time to 50% germination for P.I. 237110 or Ganada. Ganada had significantly higher respiration rates than P.I. 237110 at 0 and -0.4 MPa but not at -0.8 and -1.2 MPa. Respiration rates for both germplasm decreased as osmotic concentrations became more negative.
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Nguyên, Viêt Anh. "Problèmes de Lu Qi-Keng, théorie Hp et équation đ." Aix-Marseille 1, 2001. http://www.theses.fr/2001AIX11006.
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Cette these comprend deux parties independantes. La premiere s'interesse au probleme de lu qi-keng. Ce probleme consiste a chercher des conditions geometriques simples assurant qu'un domaine de c n est de lu qi-keng, c'est a dire que son noyau de bergman ne s'annule pas. Nous construisons des domaines algebriques concrets dans c n avec n 3 qui satisfont beaucoup de proprietes geometriques et qui ne sont pas de lu qi-keng. Notre resultat montre qu'une caracterisation simple des domaines de lu qi-keng n'est pas facile a obtenir. La seconde est consacree a developper l'analyse complexe sur une classe de domaines convexes generalisant les boules minimales et les boules euclidiennes. On commence par l'etude des espaces de hardy h p, les theoremes de type fatou et koranyi-vagi et le phenomene de nagel-stein dans la boule minimale. On s'interesse ensuite a resoudre l'equation avec estimation lipschitzienne d'ordre 1/2 dans cette boule. Le fil conducteur de notre methode est de considerer tous ces problemes sur une variete complexe auxiliaire, puis de trouver le moyen de transporter le resultat de cette variete a la boule minimale. En generalisant cette methode, nous etablissons des estimations lipschitziennes optimales pour l'equation dans une classe de domaines convexes. Il est a noter que nos resultats sont les premiers obtenus en matiere de comportement au bord de fonctions holomorphes ainsi que de regularite lipschitzienne pour l'equation sur des domaines non homogenes, non lisses par morceaux et non strictement pseudoconvexes. Ils nous permettent de constater le role joue par la regularite du bord dans ces theories.
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Pater, Mark Joseph 1956. "A physiological comparison of two yellow bluestems (Bothriochloa ischaemum (L.) Keng.)." Thesis, The University of Arizona, 1994. http://hdl.handle.net/10150/292056.
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Yellow bluestem (Bothriochloa ischaemum (L.) Keng.) cultivars are used in conservation plantings in New Mexico, Texas and Oklahoma. The recommended cultivar in southern Arizona is Ganada. However, a population from Saudi Arabia P.I. 237110, may be better adapted to the Sonoran Desert environment. This study was conducted to determine why P.I. 237110 may be better adapted to this environment than Ganada. Morphological and physiological characteristics of P.I. 237110 and Ganada were compared in five experiments. Evaluations revealed significant differences in combined stomate densities on both leaf surfaces, leaf surface area, and water use efficiency but not in apparent photosynthesis or dark respiration. Combined average stomate density was significantly lower for P.I. 237110 than Ganada (107 vs. 136 stomates mm⁻²). P.I. 237110 had a significantly higher leaf surface area (40.5 cm²) than Ganada (25.3 cm²). Apparent photosynthetic rates were not significantly different between the populations (Ganada: 12 mumol m⁻² s-1 and P.I. 237110: 10 mumol m⁻² s⁻¹). Dark respiration rates for Ganada were not significantly different (1.4 mumol m⁻² s⁻¹) from those of P.I. 237110 (1.9 mumol m⁻² s⁻¹). P.I. 237110 required 88.9 g of water per 1 g of dry matter than Ganada which required 52.3 g of water.
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Isik, Zerrin, Tulin Ersahin, Volkan Atalay, Cevdet Aykanat, and Rengul Cetin-Atalay. "A signal transduction score flow algorithm for cyclic cellular pathway analysis, which combines transcriptome and ChIP-seq data." Royal Society of Chemistry, 2012. https://tud.qucosa.de/id/qucosa%3A27799.
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Determination of cell signalling behaviour is crucial for understanding the physiological response to a specific stimulus or drug treatment. Current approaches for large-scale data analysis do not effectively incorporate critical topological information provided by the signalling network. We herein describe a novel model- and data-driven hybrid approach, or signal transduction score flow algorithm, which allows quantitative visualization of cyclic cell signalling pathways that lead to ultimate cell responses such as survival, migration or death. This score flow algorithm translates signalling pathways as a directed graph and maps experimental data, including negative and positive feedbacks, onto gene nodes as scores, which then computationally traverse the signalling pathway until a pre-defined biological target response is attained. Initially, experimental data-driven enrichment scores of the genes were computed in a pathway, then a heuristic approach was applied using the gene score partition as a solution for protein node stoichiometry during dynamic scoring of the pathway of interest. Incorporation of a score partition during the signal flow and cyclic feedback loops in the signalling pathway significantly improves the usefulness of this model, as compared to other approaches. Evaluation of the score flow algorithm using both transcriptome and ChIP-seq data-generated signalling pathways showed good correlation with expected cellular behaviour on both KEGG and manually generated pathways. Implementation of the algorithm as a Cytoscape plug-in allows interactive visualization and analysis of KEGG pathways as well as user-generated and curated Cytoscape pathways. Moreover, the algorithm accurately predicts gene-level and global impacts of single or multiple in silico gene knockouts.Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
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Lee, Guan-kin. "Responding to eastern and western cultures in Singapore : a comparative study of Khoo Seok Wan, Lim Boon Keng and Song Ong Siang /." Online version, 1997. http://bibpurl.oclc.org/web/27351.
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Cavalli-Björkman, Christoffer, and Nicklas Lundblad. "Placing The Keg : How Five Swedish Microbreweries Position Themselves." Thesis, Linnéuniversitetet, Ekonomihögskolan, ELNU, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-19382.
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In recent years, microbreweries have become increasingly popular in both Sweden and abroad. These breweries focus on producing beer on a smaller scale, with craftsmanship and high-quality raw material as guiding principles. Today, there are around 50 microbreweries in Sweden with different backgrounds, sizes, locations, and lifespan. Given this increase in microbreweries in Sweden, the need for establishing a sturdy position on this evolving market is becoming increasingly important, and seeing that the microbreweries in this study consist of less than 13 employees, specialized knowledge of each employee becomes pivotal for the organizations’ survival and competitiveness. Therefore, the need for finding and utilizing organizational capabilities that helps them to establish and sustain a certain positioning strategy increases. In this thesis, we have interviewed and investigated five Swedish microbreweries with the purpose of describing how these microbreweries position themselves and how organizational capabilities facilitate them in reaching their positioning strategy. We investigated the microbreweries by using a qualitative research approach and designed case studies on each, which was based on both primary and secondary data. We interviewed these microbreweries by telephone, using a semi-structured interview form. Each case study was then analyzed using Hooley et al’s (1998) positioning dimensions, Porter’s (1996) positioning bases, and theories concerning organizational capabilities. The study concludes that microbreweries position themselves as a high-quality alternative, and tend to base their positioning strategy upon a needs-based view of positioning. The organizational capabilities that facilitate them in the reaching of their positioning strategies were experience, knowledge, motivation, teamwork, self-criticism, and industrial thinking.
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Yeung, Ho-king, and 楊浩鏡. "Urban fringe housing at the coast." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31984307.
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Chow, Lo-sai Pauline. "Ho Kai and Lim Boon Keng : a comparative study of tripartite loyalty of colonial Chinese elite, 1895-1912 /." [Hong Kong : University of Hong Kong], 1987. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12266292.
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Cheung, Ka-wing. "Spatial and seasonal variations of freshwater macroinvertebrates, odonata and waterbirds in Luk Keng marshland, Hong Kong." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41290951.
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Chow, Lo-sai Pauline, and 周蘿茜. "Ho Kai and Lim Boon Keng: a comparative studyof tripartite loyalty of colonial Chinese elite, 1895-1912." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1987. http://hub.hku.hk/bib/B31949265.
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Lan, On-wai Kenneth, and 藍安偉. "Rennie's Mill: the origin and evolution of a special enclave in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B36777766.
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Law, Ming. "Roles of rural towns in Hong Kong /." [Hong Kong : University of Hong Kong], 1993. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13781285.
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Liu, Ying-Jie, and 劉穎杰. "Complete subgraph construction and analysis for KEGG biological pathways." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/n43wdz.
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碩士國立臺灣海洋大學
資訊工程學系
104
Biological pathways are often used by biologists for describing a group of genes associated with specific biological functions. The interaction of a specific gene with other genes and molecules within a target species can be observed from a pathway through annotated gene locations and the relevance of linking paths. Several available pathway databases are available for researchers, however, many problems have yet to be overcome, such as slow data update rate, contradictory information among different databases and cross-pathway maps, and insufficient and hidden interaction mechanisms. In order to solve the above problems, this study proposes a novel system based on disassembling original pathway maps and recording interactive information of every gene pair. According to user’s query, the proposed system is able to construct a new comprehensive pathway map with all possible biological paths. The KEGG pathway database was applied as the original database. A total of 184 biological pathway maps collected in KEGG were decomposed in advance and all upstream and downstream relationships of identified gene pairs were stored in a look-up table. Based on the look-up table and a query gene pair (source and destination genes), the system could provide a five-level hierarchical pathway map through a real-time manner. Through finding intermediate genes between both source and destination genes, a cascaded pathway map of nine-level hierarchical pathway could be expected and formulated. In addition to construct a comprehensive pathway map from all decomposed pathways, this research also identified three different types of biological paths including shortest path, back bone, and feedback loop mechanism. All different types of pathway mechanisms could provide different biological messages. The proposed system was designed in a web browser interface with different colors, border lines, and shapes designed to distinguish different attributes. It is also noticed that integrating cross-map analysis could evoke significant increasement in both number of downstream genes and reveal numerous feedback loop mechanisms comparing to adopt a single-path graph. Nevertheless, shorter or directly transferred mechanisms obtained from cross-map integration could be detected compared to adopt a single-path graph.
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Hung, Kun-Bin, and 洪堃斌. "Quick Query Mechanism of Disease Related Signaling Pathway via GenNav and KEGG Databases." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/70577735397789025074.
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碩士國立臺灣科技大學
電機工程系
93
The purpose of this study can divide three parts to discuss. First, based on the abundant information established in Gene Navigator (GenNav) database, we construct one more friendly interface than the current query mechanism. Whereas the trend of integrating various databases currently, this query mechanism has highly extension for researchers. Second, quick query mechanism of disease signaling pathway is based on Kyoto Encyclopedia of Genes and Genomes (KEGG) database. For improving the complicated drawback of KEGG, we devote on dividing the database into three categories: disease category, growth factor, and signaling pathway. Researchers can find out the connection of different diseases through query mechanism. According to the unexpected discovery, they can design new experiments to verify the query results, so as to stretch the current metabolism pathway completely. We design the query process and manipulate coordinate concepts via ASP.NET in order to execute the query procedure automatically. Furthermore, the query information is constructed via SQL Server Enterprise Manager. Third, Meta Search Engine is implemented by C#.NET. In order to improve the disadvantage of repeated materials from different search engines, we design one query system that combines Google, Vivisimo, Baidu, Yahoo, and GAIS websites. The initial settlement of platform includes: selective search engine, sort methods in an order, repeatedly trying times in exceeding time, numbers of multiple thread, and search webpage in single time. If this system can combine with the first two mechanisms, the systematical structure may offer researchers structural databases and non-structural network resources simultaneously. Moreover, the most common used Molecular Biology Database Collection is listed in appendix of this study that can provide newcomers the detailed information. Finally, we expect genuinely this integrated query mechanism can be used to medical science, pharmacy, and the advanced technology widely in the future.
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Pereira, Nádia Neves. "SARS-COV-2 characterization – an in silico approach." Master's thesis, 2021. http://hdl.handle.net/10316/98035.
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Dissertação de Mestrado em Bioquímica apresentada à Faculdade de Ciências e TecnologiaO SARS-CoV-2 (Síndrome Respiratório Agudo Grave Coronavírus-2) já infetou mais de 225 milhões de pessoas e foi responsável por mais de 4,64 milhões de mortes em quase dois anos, tornando-se a última pandemia mundial. Ainda há muito que saber sobre este vírus e, tendo em conta a enorme quantidade de dados que surgiram desde a sua descoberta, pensámos numa abordagem que nos permitisse obter diferentes camadas de informação. Usámos text mining para obter informações de 179.984 artigos e obtivémos 10.325 genes humanos. Em seguida, usando o clusterprofiler, foi possível realizar uma análise de enriquecimento com as databases GO (Gene Ontology), KEGG (Kyoto Encyclopedia of Genes and Genomes) e MeSH (Medical Subject Headings). Os resultados de diferentes databases corresponderam, o que significa que vários termos enriquecidos estavam presentes nas diferentes análises. Analisando os resultados finais percebemos que a concentração do ião de cálcio tem um enorme impacto na evolução do COVID-19 (Coronavirus Disease 2019), a doença causada pela infeção por SARS-CoV-2. O stress oxidativo e a exposição a níveis baixos de oxigénio também são responsáveis pela evolução da severidade do COVID-19. Descobrimos múltiplos genes associados com vários dos termos enriquecidos, inclusive alguns genes que estão associados com os vários termos e a entrada e/or replicarão do SARS-CoV-2 em células humanas. Para resultados mais significativos seria necessário uma analise mais profunda e mais cuidada destes dados .
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) infected over 225 million people and was responsible for over 4.64 million deaths in almost two years, becoming the last worldwide pandemic. There is still a lot to know about this virus and, considering the huge amount of data that appeared since the virus was discovered, we needed un approach to obtain different layers of information. We used text mining techniques to gather information from 179.984 articles and we were able to retrieve 10.325 human genes. Then, we performed enrichment analysis with GO (Gene Ontology), KEGG (Kyoto Encyclopedia of Genes and Genomes) and MeSH (Medical Subject Headings) databases. The results from the different databases matched, meaning that various enriched terms were present in the different analysis. Analysing the final results we realise that calcium ion concentration has a huge impact on the evolution of COVID-19 (Coronavirus Disease 2019), the disease caused by the SARS-CoV-2 infection. Oxidative stress and exposure to low oxygen levels are also responsible for the evolution of COVID-19 severity. We discovered multiple genes associated with several of the enriched terms, including some genes that are associated with the various terms and the entry and/or replication of SARS-CoV-2 in human cells. Further and more careful analysis of these data would be required for more meaningful results. This means that this research may be continued and taken to a deeper level, in order to find new results.
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Cherkaoui, Sarah. "Développement d’une méthode bio-informatique permettant de relier les gènes aux métabolites." Thèse, 2015. http://hdl.handle.net/1866/13789.
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L’objectif de ce projet était de faire le lien entre gènes et métabolites afin d’éventuellement proposer des métabolites à mesurer en lien avec la fonction de gènes. Plus particulièrement, nous nous sommes intéressés aux gènes codant pour des protéines ayant un impact sur le métabolisme, soit les enzymes qui catalysent les réactions faisant partie intégrante des voies métaboliques. Afin de quantifier ce lien, nous avons développé une méthode bio-informatique permettant de calculer la distance qui est définie comme le nombre de réactions entre l’enzyme encodée par le gène et le métabolite dans la carte globale du métabolisme de la base de données Kyoto Encyclopedia of Genes and Genomes (KEGG). Notre hypothèse était que les métabolites d’intérêt sont des substrats/produits se trouvant à proximité des réactions catalysées par l’enzyme encodée par le gène. Afin de tester cette hypothèse et de valider la méthode, nous avons utilisé les études d’association pangénomique combinées à la métabolomique (mGWAS) car elles rapportent des associations entre variants génétiques, annotés en gènes, et métabolites mesurés. Plus précisément, la méthode a été appliquée à l’étude mGWAS par Shin et al. Bien que la couverture des associations de Shin et al. était limitée (24/299), nous avons pu valider de façon significative la proximité entre gènes et métabolites associés (P<0,01). En somme, cette méthode et ses développements futurs permettront d’interpréter de façon quantitative les associations mGWAS, de prédire quels métabolites mesurer en lien avec la fonction d’un gène et, plus généralement, de permettre une meilleure compréhension du contrôle génétique sur le métabolisme.The objective of this project was to link genes and metabolites in order to ultimately predict which metabolites to measure in order to adequately reflect the function of a given gene. Specifically, we were interested in genes, which code for proteins that regulate substrate metabolism, hence enzymes that catalyze reactions that are part of metabolic pathways. In order to quantify this link, we have developed a bioinformatics method to calculate a distance, which is defined as the number of reactions separating a given selected gene-encoded enzyme and its metabolite of interest in Kyoto Encyclopedia of Genes and Genomes (KEGG) database’s metabolic overview map. Our hypothesis was that metabolites of interest are products/substrates found at proximity of the reactions catalyzed by the selected gene-encoded enzyme. In order to test our hypothesis and validate the method, we have used genome-wide association study of metabolites levels (mGWAS) because these studies report associations between genetic variants, annotated to genes, and measured metabolites. More specifically, we used the mGWAS conducted by Shin et al. Even though the coverage of the associations reported by Shin et al. was limited (24/299), we significantly validated the proximity between gene-metabolite associated pairs (P<0.01). Overall, the method and its future developments will allow the quantitative interpretation of mGWAS associations, predict which metabolite to measure with regards to the function of a gene and, in general, enable a better understanding of the genetic control of metabolism.
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Therrien-Laperrière, Sandra. "Développement d’un outil bio-informatique pour l’annotation des associations entre gènes et métabolites basée sur les voies métaboliques." Thèse, 2017. http://hdl.handle.net/1866/20735.
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Temate, Tiagueu Yvette Charly B., and Tiagueu Yvette C. B. Temate. "Methods for Differential Analysis of Gene Expression and Metabolic Pathway Activity." 2016. http://scholarworks.gsu.edu/cs_diss/102.
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RNA-Seq is an increasingly popular approach to transcriptome profiling that uses the capabilities of next generation sequencing technologies and provides better measurement of levels of transcripts and their isoforms. In this thesis, we apply RNA-Seq protocol and transcriptome quantification to estimate gene expression and pathway activity levels. We present a novel method, called IsoDE, for differential gene expression analysis based on bootstrapping. In the first version of IsoDE, we compared the tool against four existing methods: Fisher's exact test, GFOLD, edgeR and Cuffdiff on RNA-Seq datasets generated using three different sequencing technologies, both with and without replicates. We also introduce the second version of IsoDE which runs 10 times faster than the first implementation due to some in-memory processing applied to the underlying gene expression frequencies estimation tool and we also perform more optimization on the analysis.
The second part of this thesis presents a set of tools to differentially analyze metabolic pathways from RNA-Seq data. Metabolic pathways are series of chemical reactions occurring within a cell. We focus on two main problems in metabolic pathways differential analysis, namely, differential analysis of their inferred activity level and of their estimated abundance. We validate our approaches through differential expression analysis at the transcripts and genes levels and also through real-time quantitative PCR experiments. In part Four, we present the different packages created or updated in the course of this study. We conclude with our future work plans for further improving IsoDE 2.0.
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KENG, CHIEH-SHENG, and 耿傑生. "Keng Chieh-Sheng Creative Research." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/95qhcu.
Full textAbstract:
碩士國立臺灣藝術大學
雕塑學系
107
Human lives through work, that is to say, we live, grow, and thrive in the process of labor. The different form of labor has been initiated in the history of humankind; nowadays, people are basically set in a gigantic system of division and specialization. However, the progress we got in the development of labor, does not lead us to a better life. My main concern is the crumbling relationship between human and labor; by continuous observation and artistic creation, I would like to respond to the essence of this issue, from outward phenomena to inward structure. These artworks maybe are not the whole picture of our society, but some stories that should not overlook indeed. Moreover, they would offer a potential approach for viewers to sense the situation, and to think alternative. This essay proceeds in five chapters as below. Starting from literature review based on the theme of labor, then gradually illustrate the relationship between my awareness and artistic creation, in terms of medium, artistic approach and arrangement of space. The first chapter "Motivation, Purpose and Methods" provides an overview on my awareness to the relationship between human and labor, and on the way to bridge this issue and artistic creation. The Second chapter "Labor Observation" discusses the essence of labor and the working situation in contemporary society through mass media, interviews and literature review, then followed by my response to this issue through artistic creation. The third chapter "Artworks Analysis" analyzes medium, symbol, arrangement of space and sculpture approach in my artworks by comparing with different artists' works. The fourth chapter "2018 Solo Exhibition Retrospective" throwbacks to the complete presentation of my awareness and artworks in the exhibition "Fit In". This describes my artworks on the emphasis of the combination of different medium and the arrangement of space in the solo exhibition. At last, "Conclusion" concludes my personal perspective to the labor issue and artistic creation, at the same time, seeks a possible way to go on.
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Chia, Tzu-Ching, and 賈子慶. "A Sociohistorical Analysis of the Landscape Transformation in Sanchih Hsiang Ta Keng and Chentsuo Keng." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/54364761098208050655.
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SHENG, CHEN CHIH, and 陳治生. "Taipei ShanChu Keng Landfill Place Pollution Study." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/19860932385252846586.
Full textAbstract:
碩士國立海洋大學
河海工程學系碩士在職專班
88
Taipei ShanChu Keng Landfill Place Pollution Study ABSTRACT Taipei ShanChu Keng Landfill Place，cost up to 7.4 billions NTD, capacity 6.17 millions m3，was constructed to treat the wastes from Taipei City. The treatment object was major in raw wastes until Neihu、Mucha、Petiou refuse incineration plant completed. The treatment quantity reached 522,410 meter ton by end of 2000. The defected construction has been denoted by audit system. However, it has caused leachate leached out water collection system、landfill section seal failed、 paved-clothes breached etc. for these years. Hazardous、 dissolved、 heavy metal wastes、ash dumped up on the site and without treatment. The leachate from the waste contained lead、cadmium、arsenic, which contaminated the underground water when leached out water collection system. Sewage flooded into ShanChu Keng and Da-An river, it caused downstream serious pollution. For these years, the suspending solid and heavy metal content were over the control index. The index from monitor well also proved the fact. The real pollution situation may be even more serious than the figures from the reports because the monitor system is not completed. To prohibit the contamination continuously, plant should revise the performed procedure and restrain hazardous wastes buried on site. The ash should be solidified and stored in closed buried section. The organic compounds could be treated by biological methods. After plant site take such captioned operations that the pollution can be controlled.
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Jacobson, Robert Lawrence. "Weighted Bergman Kernel Functions and the Lu Qi-keng Problem." Thesis, 2012. http://hdl.handle.net/1969.1/ETD-TAMU-2012-05-11068.
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The classical Lu Qi-keng Conjecture asks whether the Bergman kernel function for every domain is zero free. The answer is no, and several counterexamples exist in the literature. However, the more general Lu Qi-keng Problem, that of determining which domains in Cn have vanishing kernels, remains a difficult open problem in several complex variables. A challenge in studying the Lu Qi-keng Problem is that concrete formulas for kernels are generally difficult or impossible to compute. Our primary focus is on developing methods of computing concrete formulas in order to study the Lu Qi-keng Problem.
The kernel for the annulus was historically the first counterexample to the Lu Qi-keng Conjecture. We locate the zeros of the kernel for the annulus more precisely than previous authors. We develop a theory giving a formula for the weighted kernel on a general planar domain with weight the modulus squared of a meromorphic function. A consequence of this theory is a technique for computing explicit, closed-form formulas for such kernels where the weight is associated to a meromorphic kernel with a finite number of zeros on the domain. For kernels associated to meromorphic functions with an arbitrary number of zeros on the domain, we obtain a weighted version of the classical Ramadanov's Theorem which says that for a sequence of nested bounded domains exhausting a limiting domain, the sequence of associated kernels converges to the kernel associated to the limiting domain. The relationship between the zeros of the weighted kernels and the zeros of the corresponding unweighted kernels is investigated, and since these weighted kernels are related to unweighted kernels in C^2, this investigation contributes to the study of the Lu Qi-keng Problem. This theory provides a much easier technique for computing certain weighted kernels than classical techniques and provides a unifying explanation of many previously known kernel formulas. We also present and explore a generalization of the Lu Qi-keng Problem.
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Lee, Ming-Ju, and 李明儒. "Evaluative Index of Environmental Ecology in Tou-Bian-Keng Stream." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/09673437333235150332.
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博士國立中興大學
水土保持學系
92
The scope involved in evaluating ecological effect is very extensive; therefore, how to choose appropriate evaluation tools is a very important issue. This study is to discuss some evaluation indices that are popular and trustworthy. Through the investigation in the field, simple and meaningful indices were established in order to be the reference for evaluating watershed. The area of Tou-bian-ken stream watershed was been the sample area for investigation. An investigation station was established at the sections that are 50 meters in length. A total of 20 investigation stations were established. Time for investigation lasted for 8 months, starting from July 1, 2003 to February 28, 2004. In the period of investigation, hydrological quality was investigated monthly. The investigation on aquatic insects and fishes was carried out every season. The Endemic Species Research Institute helped collect the sample and authenticate the species for the study. Concerning index identification, the watershed index and landscape ecological index were adopted as the comparison and analytical variables. The environment parameters were processed by aero photograph, AicView 3.X and Feagstate for AicView. According to the result of the aero photograph and practical investigation, watershed land use was divided into 7 kinds, artificial cover, woodland, aquatic land, vacant land, grassland, farmland, and golf land. To understand the influence of different dimensions and spaces, with the inquisition points, 6 kinds of scales (with 1000 m × 1000 m, 500 m × 500 m, 200 m × 200 m, 100 m ×100 m and 50m × 50m) were compared. Through the covariance and examinations of the inquisition data, this research reaches the following conclusions: 1.The water quality of Tou-bian-ken stream is generally fit to legal standard. 2.The water quality of Tou-bian-ken stream is between excellent to good while estimating by FBI. However, the value of IBI shows a different result which reveals the water quality is between fair and very poor. The better water quality mainly lies in the upstream and the worse water quality lies in the downstream of Tou-bian-ken stream. 3.Many researches reveal land-use may affect environmental ecology, therefore the indices of landscape ecology has been selected as indicators. The research shows that the Conductivity, DO and IBI have the distinct relation with Landscape Ecology Index. 4.After the analysis of this research, it suggests that the monitor scale in physical can be made between 50m×50m and 1000m×1000m, and then the IBI scale can be made between 500m×500m.
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Liao, Min-Chun, and 廖敏君. "Studies on Reproductive Biology of Yushania niitakayamensis (Hay.) Keng f." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/41969036349966650562.
Full textAbstract:
碩士國立中興大學
森林學系
92
The Mt. Sheishan East Peak was burned on 18 February 2001 and resulted in alpine plants destroyed. In preliminary investigation, we observed Yushania niitakayamensis had flowering phenomenon in August, 2001. The present study investigates the phenology and flowering habitat of Y. niitakayamensis. In addition, Y. niitakayamensis is generally thought to be spreaded mainly by rhizomes. It is difficult to identify the demography of Y. niitakayamensis. Clonal diversity of Y. niitakayamensis from the Mt. Sheishan East Peak was investigated using inter-simple sequence repeat (ISSR) molecular markers. These studies were conducted in order to shed light on the reproductive biology of Y. niitakayamensis. The period of observation was from August 2001 to October 2003 and took approximately 26 months. The phase of flowering is from May to November every year. Seed production occurs from October to January. In 2003 we didn’t observe see production. We discovered some of individuals continued to flower at the same buds, but the inflorescences would dry soon. A floret can be resulted in one seed, mean of one hundred seeds weight about 0.74 g. The amount of flowering and seed production were the best in 2001 and decreasing year by years. No seedlings were founded. In October 2003, only 11 individuals were still alive. Some of them had pseudospikelets which look like real inflorescences and we observed one of the inflorescences comes from a rhizome. Clonal structure was examined by the ISSR (inter-simple sequence repeat) assay in 121 individuals of Y. niitakayamensis. Ten of the 125 primers screened were used in the study because they produced reproducibly amplified polymorphisms. Using these primers 164 DNA fragments were generated with 126 (76.38%) being polymorphic. One hundred and six genotypes were determined, 100 clones of them were all different individuals. Remaining 21 individuals were composed of 6 continuing clones; the largest clone covered a distance of 8 m.
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Hsu, Chia-Cheng, and 許珈錚. "A Study of Policy Advocacy on Taichung's Ta-Keng Scenic Zone." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/63135936719634121295.
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碩士國立暨南國際大學
公共行政與政策學系
97
Ta-Keng Scenic Zone is an important tourist scenic spot in Taichung. However, the policy about the development of Ta-Keng Scenic Zone had been procrastinated till last year. This study is aimed to explore the policy change by applying the Advocacy Coalition Framework (ACF), which is, to discover the stands and interactions of stakeholders and the role of Taichung government in the advocacy process through a combined viewpoint of both static system development and dynamic network relationship. It is found that the leader of local government plays a critical role in the advocacy process. However, it is also found that if the public sector takes the dominant role in the advocate process of local policy, it will also be uncertain about the local policy development and becomes a potential obstruct to the local society. Therefore the local government should actively create an adequate environment for the participation of local residents and grass groups so as to promote more advocators into the policy advocacy process and to keep the equilibrium of local policy development. Only does local policy conform with the civil opinions, policy will be implemented smoothly and civic society will work in vitality.
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liu, yan-liang, and 劉彥良. "The Research on the Petroleum Facilities Development ofChu-Huang Keng Mine." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/22713385695051822764.
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碩士中原大學
建築研究所
97
In the early four thousand years ago, humans have already been recorded for using the oil. The historical documents showed that the oil has been used since the Han Dynasty in China, whereas the huge exploitation and use of oil was originated from "Drake Oil Well", which was developed by America in 1859. The oil well was also regarded as the first one in the world. Although the well has been less than one hundred and forty years; with the influence of technological breakthrough, oil played an importance role in both people's livelihood and national defense industry. Since one century ago, the industry of oil has been a symbol for appearance of modern industry. Oil was not merely regarded as merchandise, but also had much closer connection between politics and power in the world. Located in the southern part of Gongguan Township in Miaoli County, the Chu-Huang Keng was the earliest and the most important oil exploitation area. According to the historical records, in 1861 (Xianfeng 11th year) Kou Chiu who is Guangdong origin discovered oil under the riverbed near the Houlung River, Chu-Huang Keng, and dug an oil well which was made by man-made. As a result, there was no large amount of oil reservation, but there was a long-lasting history of discovery and exploitation. The place, Chu-Huang Keng, has been exploited and run from the Ching Dynasty to Japanese ruled periods, and after the World War II. So far, it still has been run for the facilities of the oil industry, owing a great diversity of cultural assets which were left form different periods. According to the statements above, and take the Chu-Huang Keng for example, the following are the objectives of this research, based on the procedures of the oil industry and villages, such as facilities of oil, from Ching Dynasty to Japanese ruled period, and after the World War II. 1. To understand the exploitation and procedures of running about Chu-Huang Keng in different periods from Ching Dynasty to Japanese ruled period, and after the World War II, by collecting and analyzing different periods of historical documents. 2. To analyze the mutual effects on space and development between the facilities of the industry and Chu-Huang Keng villages about the oil industry in Chu-Huang Keng, based on the reclamation of Hakka people in Ching Dynasty, exploitation via privatization from Japanese ruled period, and the procedures of management and exploitation after the World War II. 3. By means of filed research and analyses, to understand the present development conditions of Chu-Huang Keng oil industry and villages, and to analyze the landscapes of mining industry and formation of cultural assets about Chu-Huang Keng. It is expected that the report can be regarded as references not only for the research on Taiwan's oil industry development, but also on relevant and continued research, as well as preservation for the foundation of oil industry heritages.
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施慶煌. "A Study on River Pollution Level of Ta-Keng Creek Watershed." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/89286511394969349156.
Full textAbstract:
碩士國立中興大學
水土保持學系
88
This study set up five gathering stations to sample stream water monthly for examining pollution status of the streams in Ta-Keng watershed. Analysis item includes discharge, water temperature, pH, EC, DO, SS, turbidity, BOD, HN3-N, T-P, T-N, NO3-N, NO2-N, TKN and coliform. Results show that water quality in the watershed is graded as class A according to the landscape surface water classification and standard. Stream water quality belongs to slightly and/or not polluted class using the calculation of River Pollution Index (RPI). It is obvious that water quality in dry season has worse index toward that in rainy season. Using geographic information system and image analysis, there are 5.28 ha landslides occurred in the watershed of interest after the hit of earthquake on SEP. 21st 1999. No obvious variation of SS (2mg/L∼10mg/L ) detected on the sunny day during this study. However, two-single event precipitation (37~38mm) selected before and after the quake, there is a dramatic rising in SS detected after the quake. Watershed analysis show that about 58.05% of total area having the amount of annual sediment yield less than 5 tons. The sites where sediment yield more than 35 tons/yr occupied 24.68% of total area are located at the riparian. Most landslides induced by the quake occurred at the upstream of Ta-Keng creek. The average turbidity and SS (Shuang-Lian bridge 108 NTU/208.7mg/L, Goang-Der bridge 109.7NTU/174.1 mg/L, Goang-Shenq bridge 68.4NTU/60.4 mg/L, Guang-ming bridge 40.7NTU/67.1 mg/L) monitored at the sampling stations show that the bridges located at the upstream having higher turbidity and SS comparison with those at the downstream. The landslides caused by the quake plays an important role on the worse water quality of Ta-Keng creek.
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Chen, Cheng-Ping, and 陳正平. "Study of the Autumn Lyrics during the Rebellion of Keng Tzu." Thesis, 1995. http://ndltd.ncl.edu.tw/handle/63820791972783926260.
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Lin, Su-Ting, and 林淑婷. "Reproductive incompetence of Taiwania crytomeriodies Hay. in Yeou-Shoei-Keng clonal orchard." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/48817070717135690546.
Full textAbstract:
碩士國立臺灣大學
森林學研究所
90
The clonal orchard was set with grafting in 1966 at Yeoi-Shoei-Keng, Chitou District, The Experimental Forest of National Taiwan University. To the present, it still can’t produce filled seeds. The objective of this study was to understand the reason which causes the failure of seed production. We investigated the pollen-production ability of male strobili and the development of ovules. In addition, we take artificial pollination to examine seed production ability. Results indicated that during 1999 to 2000 all the seeds produced in the orchard were empty. There was 35.33﹪of trees in the orchard having male strobili, however, all of them withered before maturation. Female strobili were dormant from October, 2000 to April, 2001. Microstructures of ovules were sound and they secreted pollination drops regularly on April 16, 2001. The pollination drops functioned normally for catching the pollens. We collected the maturation cones induced by artificial pollination on December 1, 2001. Although effective seeds were in a small proportion, the germination percentage of effective seeds was more than 91.88﹪. The 4 month-old seedlings grew well. Therefore, the reason which causes failure of seed production of the seed orchard is the abortion of female strobili.
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Wu, Sen-Yuan, and 吳森源. "Purification and Characterization of Esterase/Lipase from Tai Keng 9 Rice Bran." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/65056447718556240516.
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碩士朝陽科技大學
生化科技研究所碩士班
99
Rice bran is a by-product during rice milling, containing abundant oils, functional components, antioxidants, and many lipolytic enzymes (EC 3.1.1.X.) as well. Among the enzymes carboxylesterase (EC 3.1.1.1) and lipase (EC 3.1.1.3) are very important, because they may cause rancidification during rice grain storage. In this study, we have used rice cultivar Tai-Keng 9 (TK9) to isolate and purify esterase/lipase. Through studying the biochemical characteristics and substrate specificities of the enzyme, we expect to employ this information on rice breeding in the future. The rice bran crude enzymes were analyzed by SDS-PAGE and esterase activity staining, showing a single activity band about 21.5 kDa. When analyzed with native-PAGE four active bands were observed. Short-chain fatty acid ester (p-nitrophenyl butyrate) and long-chain fatty acid ester (p-nitrophenyl palmitate) were used for esterase and lipase activities analyses, and their specific activities were 157 and 1.66 U/mg protein, respectively. It indicated the existence of both activities of esterase and lipase in the extract, but the former was more significant than the latter. The crude extract was subjected to 20-70% ammonium sulfate saturation precipitation and three columns of chromatography were conducted, including resins superdex75, Hi-Trap DEAE FF and then superdex75. Two lipolytic enzymes were separated and dubbed as lipase I (21.5 kDa) and lipase II (22 kDa) with pI 4.5 and 8.4, respectively, resolved by two-dimensional gel electrophoresis. The purification fold and recovery were 86.3 and 0.24% for lipase I, and 7.74 and 2.96% for lipase II. Activity stain of electrophoretic gels showed that both enzymes were able to hydrolyze α-naphthyl butyrate (C4) and β-naphthyl oleate (C18:1), while lipase I showed a higher activity toward β-naphthyl oleate (C18:1) than did lipase II. The study of biochemical characteristics showed that both enzymes had similar optimal temperature and pH at 40 ℃ and pH 9.0, respectively. The thermal stability of lipase II was slightly higher than that of lipase I. The study of substrate specificity showed that lipase I preferred short-chain fatty acid esters, and lipase II short- and medium-chain fatty acid esters. The chemical reagent retreatment experiments showed that both enzymes were effectively inhibited by 1 mM PMSF or 1 mM EDTA; 1 mM of DTT and IAA bore similar inhibition effects; 1 mM SDS significantly reduced the activities of lipase I and lipase II, and 5 mM almost completely inhibited the activity of lipase II. These results may suggest that their active centers are composed of serine or cysteine, their proteins structures contain disulfide bond(s), their activity performance needs divalent metal ion(s), and the structure of lipase I is more tolerable than lipase II.
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Jiang, Joung-pao, and 江榮堡. "PERFORMANCE EVALUATION OF HOME STAY MANAGEMENT IN GU-KENG AREA, YUNLIN COUNTY." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/32vvws.
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碩士南華大學
管理科學研究所
95
The purpose of this study is to explore performance efficiencies of Home –stays (hostels) particularly the twenty Home Stay managements in Yunlin County. Performance output information from data envelop analysis（DEA）is combined with performance output estimation while Frontier software is used to obtain efficiency values of Data Envelopment Analysis. (DEA) Technical Efficiency; Scale Efficiency, Production Efficiency, Return to Scale and Sensitivity Analysis are discussed. In addition, Efficiency Affection Index（EAI）is applied to discuss the relationship between input/output items and total performance outcomes. This study is conducted to analyze future trends and propose benchmarks that conform to future needs. Decision-makers will be able to react to situations and maintain reasonable resource allocations in home-stay management applications in the future.
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Phooi, Mun-Ket, and 潘文杰. "Malaysian Chinese Cinema and Identity Politics: Implications from Chiu Keng Guan’s Films." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/uneazk.
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Min-Chen, Wang, and 王旻臻. "Social Networks and Early Development of Ong-Keng Presbyterian Church in Taiwan." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/21366661813084186048.
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碩士東海大學
宗教研究所
98
Abstract The purpose of this study is to explore the establishment and early development of Ong-Keng Presbyterian Church in Taiwan, adopting the framework of social network theory. That is to say, to analyze the establishment and development process of Ong-Keng Church through social network of internal members to connect with tangible and intangible resources. The research scope is set from the establishment of the church in 1947 through to 1968, using a qualitative research method. The dates were set after in-depth interviews with important people who participated in the church during these twenty-two years and after collecting relevant literature. The aim is to reconstruct the early history of Ong-Keng Presbyterian Church. The analysis is divided into three parts：（1）Family networks link and the establishment of Ong-Keng Church ；（2）Extension of the church’s internal networks and the establishment of Cha-Uo Church；（3）The internal and external resources, and the development of Ong-Keng Church. The finding revealed that several extended families in Ong-Keng were related to the development of the church. This church developed close relationships with several families who provided resources for its establishment and development. In addition, members with geographical network who brought the human and material resources could become branches of this church. The essay concludes that linking of social networks is a major basis of membership and resources, and in promoting the establishment and development of new religious organizations.
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Chen, So-peng, and 陳壽彭. "STUDY ON APPLICATION OF ECOLOGICAL ENGINEERING IN THE GUEI-ZI-KENG MOUNTAINEERING FOOTPATH." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/20940306299890355161.
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碩士大同大學
工程管理碩士在職專班
101
This study has established an initial methodology of evaluation indicators of ecological engineering method on Guei-Zi Keng Mountaineering Footpath. We also collected the literatures and research reports proposed by previous studies in order to obtain the hierarchic indices of ecological engineering method. Further, it classified the major criteria by Analytic Hierarchy Process after collecting the questionnaire survey by engineering experts. The hierarchic structures included the evaluation of ecological engineering method as the goal in the first tier; three evaluation dimensions for the goal including the gist of ecological engineering method, consideration of ecological engineering method and consideration of construction management as the second tiers; and 11 criteria for evaluation as the third tiers. The results indicated the top three criteria used for weight calculation are the sheer difficulty of construction management, offer good soil and water conservation and preserve the ecological environment. The weight of every criteria and hierarchy indices could be calculated, which provided the government a reference to make a policy decision on promotion the ecological engineering method.
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Chou, Tao-hung, and 周道宏. "Exploring Cultural Landscape Preservation Mechanism From Induatry Process in Miaoli Chu Huang Keng." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/96202170373245268947.
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碩士朝陽科技大學
建築及都市設計研究所
99
In recent years , many scholars engaged themselves in research on cultural assets from industry. Among the many types of industrial cultural heritage, oil field industry is an important lifeline for the development of country''s industrial economy. The oil field industry in Taiwan, Miaoli County''s Chu-Huang-Keng, mining development indicators for Taiwan, witnessed the rise and fall of Taiwan''s oil field industry , as Chu-Huang-Keng began drilling for oil in the late Qing Dynasty , and is currently the world''s second oldest still in production at mines. Therefore, evaluated as high cultural value of the assets, Chu-Huang-Keng will be logged in by the C.C.A as a cultural landscape,and be planned for demonstration area as "local based cultural assets". The original casts of idle industrial space, will be revitalized combining cultural assets and tourism industry. This research studied and analyzed the cultural landscape, cultural assets, the definition of industry , and cultural heritage preservation issues facing the work, theory and implications , with reference to relevant case operation, to further explore the Chu-Huang-Keng the value of cultural landscape preservation. Through literature review , secondary data analysis, historical research and field research, etc. Systematic collation and induction of the Miaoli Chu-Huang-Keng cultural landscape preservation issues and development strategies , and construct Chu-Huang-Keng cultural landscape preservation values three: Social value of surface , face value of the estate, development of face value. Eventually , by the Analytic Hierarchy Process, expert questionnaire assessing the conservation value selected indicators. Findings of this study have the following three points, as described below: 1. Research and Analysis from important historical context of industrial development, as well as former members of the work situation and the process of further refining industry analysis process of Miaoli Chu-Huang-Keng. 2. By Chu-Huang-Keng oil and gas exploration and mining industry to discuss the various stages of life history of mining exploration capabilities and industrial production processes , to explore the value of the local cultural landscape. 3. Construction Chu-Huang-Keng cultural landscape conservation value index.
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Kuan-tingChen and 陳冠廷. "A study on the synthesis of ultramarine from mudstones of Kuting-Keng formation." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/t4mkck.
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博士國立成功大學
資源工程學系
103
In southern Taiwan, the western foothill in Tainan-Kaohsiung county is the exposed area of Pliocene (5.3 million years ago) to early Pleistocene (1.6 million years ago) strata composed of a thick grey mudstone series which is 5000 metres in depth, named as Kutingkeng Formation. The appearance of its typical badlands is specifically called “Moon World.” The mineral compositions of Kutingkeng Formation are extremely fine quartz, which takes 40%~60% , clay minerals and a small amount of feldspar (〈5%). The clay minerals consist of illite (45-65% of total clay), clinochlore (35-40 %) and a small amount of swelling clays (5-10%). Generally, the mudstone of Kutingkeng Formation does not have important economic applications. This study was based on the research of synthetic zeolite and designed by Taguchi method. Three starting materials were used: the in-situ sample (as received), the 〈2 ㎛ part and the synthetic cancrinite. Each were mixed separately with sulfur, sodium carbonate and activated carbon and then calcinated at assigned temperatures. This study investigates the influences of starting material, reaction temperature, retention time, sodium / sulfur molar ratio and the weight ratio of activated carbon on hue, chrome and brightness of the ultramarine obtained. In this results show that ultramarine blue can be synthesized by in-situ sample (as received), the 〈2 ㎛ part and the synthetic cancrinite after calcination.
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Huang, Yu-Chen, and 黃育珍. "A Study of slopeland rational conservation and managerment in Da-keng area, Taichung." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/89511647903607073736.
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博士國立中興大學
水土保持學系所
100
Dakeng area are known as City Garden of Taichung. In addition to the agricultural production, the government is trying hard tp promote the integration of leisure and tourism, agriculture and water resources for a new social area "Da-Sing life circle" to expand the scale of industry in both tourism and agriculture in recent years. This study investigate the potential and problems of Da-keng area slope land in terms of on slope stability, distribution of water resources, tourism-oriented development and urban planning. In study of the influence of geological factor on slope stability, the results show that 368 hectares-wide potential land slide zone area in Da-keng area PQc accounted for 21.3% of the potential land slide zone and P2 only 7.1%. This results also indicate that in potential analysis of regionalization of landslides in the past years, impact factor selected in analysis is significant for PQc geological formation. In analysis in the influence of various factors in different geological, PQc geological formation and PQs geological formation, more affected by slope geological formation;P2 geological formation is governed by slope aspect. In terms of landslide potential analysis, this study used “instability index method” to prediction of the potential hazard of study area. The results in this analysis showed that within the total study area of 3,543 hectares, the highest proportion are in landslide potential # 4(40%~50% )and #5(50%~60%), a total area is about 1,676 hectares and 1,207 hectares, accounts for about 46.8% and 33.7% of the study area. Bridges, roads and buildings are the targets for soil and water conservation within the study area, Farm road length in high landslide susceptibility area is about 8,832 meters which is 9.2% of the road length in Da-keng. Buildings located in landslide potential #4(40%~50% )and above is about 28, 1.05% percent of total buildings amount in study area. These buildings are mainly located in northeastern region of Da-keng area. Water is very important to sustainable development of a given area. For the supply and distribution of water resources in Da-Keng study area, Min-zen and Min-te village have lower Tap-Water supply connection rate in the district. If statistics by individual road, Da-Hu and Chu-keng lane have lower tap-Water supply connection rate about 57.5％and 25.0％. To help the development of the tourism industry in Da-Keng area, it is important that the tap-water connection rate should be upgraded. In terms of agricultural irrigation assessment , if completing the planning agricultural irrigation systems of Da-keng area can only be completed will with waters from streams. Irrigation could cover the irrigation area of bamboo shoots to 23.7% and 29.4% for irrigation area of citrus products. Irrigation range can even be expanded substantially to 80.6% and 83.3％ with irrigation facilities improvement. To reduce the danger of landslide occurrence due to high groundwater and searching for alternate sources of water , this study assessed the suitabilities of removing extra water in the ground for use elsewhere downslope to improve agriculture water supply in this area. This study collect topographic, landform and geological data at 5 study sites in the Da-keng area. Geological logging, resistance physical detection and field check were used to investigate the suitabilities of these 5 sites. The results show that these 5 sites, 3(#1,#2,#4) were suitable because their geological and topographical conditions are favorable to high groundwater storage. In groundwater drainage investigation, the highest drainage is 0.00361cms for the site#1 and the lowest is 0.00005cms for site#3. In assessment of the feasibility that use ground water for alternative main source of agricultural water consumption, the highest replacement ratio is 16.79% for the site#1 and the lowest is 1.26% for site#4. In study on evaluation of low density leisure travel development strategy, it is necessary to take watershed conservation concepts in terms of special geology and environment conditions in Da-Keng area. Massive disturbance of surface should be avoided for land utilization in the slope land region. To achieve the goal of sustainable land conservation, and a rational land use policies consider land conditions and characteristic should be considered and critically evaluated. All efforts should be made to apply site-specific water and soil conservation measures to reduce geology hazard risk. In past 20 years, because of Da-keng area did not have specific land use zoning institution in urban planning, there are many arguments in review processes, factors related to geological issue , landscape and building coverage ratio are considered under the existing land development permitted review system. This study evaluate the draft urban planning using geographical statistics method. In draft urban planning, 80% of residential zone are slope classification #3. Land utilization and construction management in this zone should still be implemented in the future to strengthen the slope land utilization review to avoid potential disaster. In study on the geological disaster density in each zone during draft urban planning, shallow collapse density that occur in residential zone and scenic zone that allows for construction are relatively low. Although residential zone and scenic zone suspected dip slope landslide disasters density is lower than agricultural zone and protection zone, this disaster is still an important factor that construction will be considered in future.
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Chen, Sheng-De, and 陳昇德. "Stabilization and Stability Analyses of Shi-Shui-Keng Landslide Using Various Remedial Countermeasures." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/89683858498560389213.
Full textAbstract:
碩士國立中興大學
水土保持學系所
98
This study established the numerical model of Shi-Shui-Keng landslides (S-S-K landslides) using TALREN-4 numerical tool according to the field investigations and the in-situ monitoring such as the geological boring data, the instrumentations of inclinometer and the records of groundwater level. In addition, a series of stability analyses were carried out on the S-S-K landslides remedied by various construction plans. Based on the numerical results of stability analyses, the failure mechanism of sliding surface can be captured. Subsequently, a systematic parametric study was performed on the design variables of two stabilization methods, namely, pile wall and anchor to examine the possible influence of the design variables on the potential sliding surface. It was found that to stabilize a large scale of landslides the slope stability can be significantly enhanced if the rigid-type of pile wall is adopted as the stabilization method. According to the numerical results of parametric study on the design variables of stabilization methods, the following conclusions can be drawn. The installation parameter Rx=0.5 can give the optimum location for pile wall to penetrate the sliding surface and obtain the most effective enhancement to the slope stability. On the other hand, for a specific installation angle of anchor