Relevant bibliographies by topics / Kelch-like ECH-associated protein 1

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Kelch-like ECH-associated protein 1'

Author: Grafiati
Published: 5 June 2025
Last updated: 16 July 2025

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Journal articles on the topic "Kelch-like ECH-associated protein 1"

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Scheffler, Matthias. "„Kelch-like ECH-associated protein 1“ (KEAP1)." Trillium Krebsmedizin 33, no. 4 (2024): 276–81. http://dx.doi.org/10.47184/tk.2024.04.8.

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In gesunden Zellen liegt das „Kelch-like ECH-associated protein 1“ (­KEAP1) im Zellplasma vor und ist dort gebunden an das Protein NRF2. Der KEAP1-NRF2-Signalweg schützt die Zelle gegen oxidativen und metabolischen Stress. Zudem verhilft er den Zellen dazu, körperfremde chemische Verbindungen (Xenobiotika) zu tolerieren. Grundlegend hierfür sind über den KEAP1-NRF2-Signalweg angestoßene Mechanismen, die die Zelle vor dem Tod durch oxidativen Stress (Ferroptose) bewahren, sie entgiften und den Stoffwechsel reprogrammieren. Liegen jedoch Mutationen in einem Gen oder beiden Genen vor, wird der no
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Cai, Min, Li Tong, Beibei Dong, Wugang Hou, Likai Shi, and Hailong Dong. "Kelch-like ECH-associated Protein 1-dependent Nuclear Factor-E2–related Factor 2 Activation in Relation to Antioxidation Induced by Sevoflurane Preconditioning." Anesthesiology 126, no. 3 (2017): 507–21. http://dx.doi.org/10.1097/aln.0000000000001485.

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Abstract Background The authors have reported that antioxidative effects play a crucial role in the volatile anesthetic-induced neuroprotection. Accumulated evidence shows that endogenous antioxidation could be up-regulated by nuclear factor-E2–related factor 2 through multiple pathways. However, whether nuclear factor-E2–related factor 2 activation is modulated by sevoflurane preconditioning and, if so, what is the signaling cascade underlying upstream of this activation are still unknown. Methods Sevoflurane preconditioning in mice was performed with sevoflurane (2.5%) 1 h per day for five c
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Holland, Ryan, and James C. Fishbein. "Chemistry of the Cysteine Sensors in Kelch-Like ECH-Associated Protein 1." Antioxidants & Redox Signaling 13, no. 11 (2010): 1749–61. http://dx.doi.org/10.1089/ars.2010.3273.

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Sykiotis, Gerasimos P. "Keap1/Nrf2 Signaling Pathway." Antioxidants 10, no. 6 (2021): 828. http://dx.doi.org/10.3390/antiox10060828.

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Nuclear factor, erythroid 2-like transcription factor 2 (Nrf2) and its cytoplasmic inhibitor, kelch-like ECH-associated protein 1 (Keap1), comprise a redox-responsive endogenous antioxidant defense module that orchestrates the expression of cytoprotective genes to maintain homeostasis [...]
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Qu, Lingzhi, Ming Guo, Huajun Zhang, et al. "Characterization of the modification of Kelch-like ECH-associated protein 1 by different fumarates." Biochemical and Biophysical Research Communications 605 (May 2022): 9–15. http://dx.doi.org/10.1016/j.bbrc.2022.03.059.

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Cairang, Nanjia, Yanran Wu, Shumeng Zhi, et al. "5-(3-(N-(Carboxymethyl)naphthalene-2-sulfonamido)phenyl)-1-ethyl-1H-pyrrole-2-carboxylic acid as a Keap1–Nrf2 inhibitor for cerebral ischemia/reperfusion injury treatment." RSC Advances 15, no. 2 (2025): 1052–59. https://doi.org/10.1039/d4ra06512c.

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The Keap1 (Kelch-like ECH-Associating Protein 1)–Nrf2 (Nuclear Factor Erythroid 2-Related Factor 2)-ARE (Antioxidant Response Element) signaling pathway plays a crucial role in the oxidative stress response and has been linked to the development and progression of various diseases.
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De Vita, Simona, Milena Masullo, Sabrina Grambone, Paloma Bermejo Bescós, Sonia Piacente, and Giuseppe Bifulco. "Demethylcalabaxanthone from Garcinia mangostana Exerts Antioxidant Effects through the Activation of the Nrf2 Pathway as Assessed via Molecular Docking and Biological Evaluation." Antioxidants 12, no. 11 (2023): 1980. http://dx.doi.org/10.3390/antiox12111980.

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Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway activation promotes the expression of antioxidant enzymes in response to rising oxidative stress, resulting in reactive oxygen species (ROS) detoxification and playing a central role in the maintenance of intracellular redox homeostasis and regulation of inflammation. Moreover, the biological effects of Nrf2 pathway activation contribute to reducing apoptosis and enhancing cell survival. The activity of Nrf2 is negatively regulated by Kelch-like ECH-associated protein 1 (Keap1). Prompted by the recent results reporting the impact of xa
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Mulvaney, Kathleen M., Jacob P. Matson, Priscila F. Siesser, et al. "Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate." Journal of Biological Chemistry 291, no. 45 (2016): 23719–33. http://dx.doi.org/10.1074/jbc.m116.729418.

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Sogabe, Satoshi, Kotaro Sakamoto, Yusuke Kamada, Akito Kadotani, Yasunori Fukuda, and Jun-ichi Sakamoto. "Discovery of a Kelch-like ECH-associated protein 1-inhibitory tetrapeptide and its structural characterization." Biochemical and Biophysical Research Communications 486, no. 3 (2017): 620–25. http://dx.doi.org/10.1016/j.bbrc.2017.03.038.

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Long, Xiangju, Zhe Liu, Yanan Sun, and Hong Zhang. "The Protective Role of Nrf2 in Renal Tubular Cells in Oxidised Low-Density Lipoprotein-Induced Fibrosis." Analytical Cellular Pathology 2023 (March 11, 2023): 1–8. http://dx.doi.org/10.1155/2023/4134928.

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Background: CD36 is the receptor of oxidised low-density lipoprotein (OxLDL) in renal tubular epithelial cells. Nuclear factor erythroid 2-related factor 2 (Nrf2) is the key factor in the activation of the Nrf2 signalling pathway and the regulation of oxidative stress. Kelch-like ECH-associated protein 1 (Keap1) is known as an Nrf2 inhibitor. Methods: We used OxLDL and Nrf2 inhibitors at different concentrations and durations to treat renal tubular epithelial cells; the expression of CD36 and cytoplasmic and nucleic Nrf2 and E-cadherin in those cells were observed by Western blot and reverse-t
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Dissertations / Theses on the topic "Kelch-like ECH-associated protein 1"

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Tian, Wang, la Vega Montserrat Rojo de, Cody J. Schmidlin, Aikseng Ooi, and Donna D. Zhang. "Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2–related factors 1 and 2 (NRF1 and NRF2)." AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2018. http://hdl.handle.net/10150/627124.

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Nuclear factor erythroid-2-related factor 1 (NRF1) and NRF2 are essential for maintaining redox homeostasis and coordinating cellular stress responses. They are highly homologous transcription factors that regulate the expression of genes bearing antioxidant-response elements (AREs). Genetic ablation of NRF1 or NRF2 results in vastly different phenotypic outcomes, implying that they play different roles and may be differentially regulated. Kelch-like ECH-associated protein 1 (KEAP1) is the main negative regulator of NRF2 and mediates ubiquitylation and degradation of NRF2 through its NRF2-ECH
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Nanayakkara, Sachith N. "The role of IGF-1 and hormone binding proteins in understanding insulin-associated equine laminitis." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/118300/1/Sachith_Nanayakkara_Thesis.pdf.

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Laminitis is a common and extremely painful hoof disease in horses. We know that it is caused by abnormally high levels of insulin, but the mechanism of insulin action is not known. One theory is that insulin over-stimulates the receptors for a related hormone, insulin-like growth factor-1, and that this leads to uncontrolled cell proliferation in the hoof, which ultimately causes the disease. The first part of the thesis examines this theory, by determining if insulin can activate IGF-1 receptors directly, or displace IGF-1 from its binding proteins in blood, thereby increasing the activity o
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Hari, Priya. "Identification and study of a role for toll-like receptors in oncogene-induced senescence." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31443.

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Oncogene-induced senescence (OIS) is a fail-safe mechanism activated to halt the proliferation of cells at risk of malignant transformation. It is a cell cycle arrest program of biological changes to the cell comprising of the activation of tumour suppressor pathways, altered cellular metabolism, extensive chromatin remodelling and the activation of a senescence-associated secretory phenotype (SASP). The vast array of proteins secreted by the cells not only play a cell-autonomous role in reinforcing the senescence phenotype, but also modulate the cell's micro-environment by inducing senescence
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Bryan, Nicole B. "Subcellular distribution of apoptosis associated speck-like protein mediates inflammasome assembly a novel mechanism in the regulation of interleukin-1beta release /." Morgantown, W. Va. : [West Virginia University Libraries], 2010. http://hdl.handle.net/10450/11239.

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Thesis (Ph. D.)--West Virginia University, 2010.<br>Title from document title page. Document formatted into pages; contains x, 182 p. : ill. (some col.). Includes abstract. Includes bibliographical references.
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Kajita, Yoichiro. "The transcription factor Sp3 regulates the expression of a metastasis-related marker of sarcoma, actin filament-associated protein 1-like 1(AFAP1L1)." Kyoto University, 2013. http://hdl.handle.net/2433/179345.

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Schulze, Andrea. "A role for the ubiquitin domain protein HERP in ER-associated protein degradation." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2007. http://dx.doi.org/10.18452/15575.

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Die ER-assoziierte Proteindegradation (ERAD) ist Teil des Qualitätskontrollsystems am ER, um der Akkumulation von fehlgefalteten Proteinen im ER entgegenzuwirken. Hierbei werden ERAD-Substrate mit Hilfe von E3-Ligasen wie z.B. HRD1 ubiquityliert und anschließend durch den p97-Ufd1-Npl4 Komplex aus der ER-Membran extrahiert. Im Zytosol werden diese extrahierten Proteine vom 26S Proteasom abgebaut. Für die Retrotranslokation von ERAD- Substraten werden zudem die Membranproteine Derlin-1 und VIMP benötigt, welche mit p97 assoziieren und einen Proteinkomplex bilden. HERP ist ein ER-lo
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SEVERA, MARTINA. "Toll-like receptor-mediated induction of type I interferons promotes functional modifications and changing in the gene expression profile along dendritic cell maturation." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/979.

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Le cellule dendritiche (DC) sono considerate le principali cellule presentanti l`antigene per la loro straordinaria capacità di modulare sia la risposta innata che quella adattativa. Il riconoscimento dei patogeni da parte dei Toll-like Receptors (TLR) induce la maturazione delle DC e la successiva produzione di citochine necessarie per la regolazione della risposta immunitaria. Tra le citochine prodotte, gli Interferoni di tipo I (IFN) svolgono un ruolo chiave nella regolazione della risposta immunitaria in quanto, oltre a regolare la proliferazione, differenziamento e maturazione di diverse
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Li, Chia-Feng, and 李嘉峰. "The Mechanism of Kelch-Like ECH-Associated Protein 1( Keap1) in Lung Adenocarcinoma Migration." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/54783667330135466675.

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碩士<br>國立臺灣大學<br>毒理學研究所<br>99<br>Kelch-loke ECH-associated protein 1(KEAP1) is a redox-dependent substrate adaptor protein which interact with cul3 ubiquitin ligase complex to degradate NRF2(NF-E2-related factor 2). The decreased expression of KEAP1 will enhance NRF2 expression and accumulate in the nucleus, where binding with antioxidant responsive element(ARE) and activate the antioxidative enzyme expression. Here we observed the KEAP1 expression had inversely correlation with cell migration ability. So we suggesting that the NRF2 target gene may provide advantage for cancer cell progression
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Hsieh, Feng-Koo, and 謝逢轂. "The Role of Kelch-Like ECH-Associated Protein 1 (KEAP1) in Lung Adenocarcinoma Migration and Invasion." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/31961946583141266157.

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碩士<br>國立臺灣大學<br>毒理學研究所<br>96<br>Previous studies revealed that weakened KEAP1 (Kelch liked ECH-associated protein 1) expression enhanced NRF2 (NF-E2-related factor 2) nuclear accumulation and elevated antioxidant responsive element (ARE)-mediated induction of phase II detoxifying and oxidative stress enzyme genes such as antioxidative and antixenobiotic stress enzymes and drug efflux pumps in non-small cell lung cancer, suggesting that gave lung cancer cells multiple advantages for proliferation. However, recent studies indicated that NRF2 was not correlated with reduced survival or overall su
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Hsieh, Feng-Koo. "The Role of Kelch-Like ECH-Associated Protein 1 (KEAP1) in Lung Adenocarcinoma Migration and Invasion." 2008. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2907200817025900.

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Books on the topic "Kelch-like ECH-associated protein 1"

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Voll, Reinhard E., and Barbara M. Bröker. Innate vs acquired immunity. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0048.

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The innate and the adaptive immune system efficiently cooperate to protect us from infections. The ancient innate immune system, dating back to the first multicellular organisms, utilizes phagocytic cells, soluble antimicrobial peptides, and the complement system for an immediate line of defence against pathogens. Using a limited number of germline-encoded pattern recognition receptors including the Toll-like, RIG-1-like, and NOD-like receptors, the innate immune system recognizes so-called pathogen-associated molecular patterns (PAMPs). PAMPs are specific for groups of related microorganisms
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Book chapters on the topic "Kelch-like ECH-associated protein 1"

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Saidak, Zuzana, Zakaria Ezzoukhry, Jean-Claude Maziere, et al. "BAX (BCl2-Associated X Protein), BCL2L4 (BCL-2 Like 4)." In Encyclopedia of Signaling Molecules. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100109.

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Grossman, Gregory H., Craig D. Beight, Lindsey A. Ebke, Gayle J. T. Pauer, and Stephanie A. Hagstrom. "Interaction of Tubby-Like Protein-1 (Tulp1) and Microtubule-Associated Protein (MAP) 1A and MAP1B in the Mouse Retina." In Retinal Degenerative Diseases. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-3209-8_65.

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Bouchenafa, Ouahiba, and John Littleton. "Super-Induction of C-FOS-Like Protein in Bovine Adrenal Chromaffin Cells Associated with Ethanol Withdrawal." In Alcohol, Cell Membranes, and Signal Transduction in Brain. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2470-0_27.

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Kadota, Yasuhiro, Alberto P. Macho, and Cyril Zipfel. "Immunoprecipitation of Plasma Membrane Receptor-Like Kinases for Identification of Phosphorylation Sites and Associated Proteins." In Plant Signal Transduction. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3115-6_11.

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Štrop, P., M. Hořejší, J. Konvalinka, et al. "Protein-Engineered Proteinase of Myeloblastosis Associated Virus, An Enzyme of High Activity and HIV-1 Proteinase-Like Specificity." In Advances in Experimental Medicine and Biology. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-6012-4_68.

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Saidak, Zuzana, Zakaria Ezzoukhry, Jean-Claude Maziere, et al. "BAD (BCL-2-Associated Agonist of Cell Death), BBC6 (BCL2-Binding Component 6), BCL2L8 (BCL2-Like Protein 8)." In Encyclopedia of Signaling Molecules. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100104.

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De Paula Vieira, Andreia, and Raymond Anthony. "Reimagining Human Responsibility Towards Animals for Disaster Management in the Anthropocene." In The International Library of Environmental, Agricultural and Food Ethics. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63523-7_13.

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AbstractAnimals, like human beings, are prone to suffering harms, such as disease, injury and death, as a result of anthropogenic and natural disasters. Animals are disproportionately prone to risk and adversely affected by disasters, and thus require humane and respectful care when disasters strike, due to socially situated vulnerabilities based on how human communities assess and value their moral standing and function. The inability to integrate animals into disaster risk and management practices and processes can sometimes be associated with a lack of understanding about what animal ethics and animal health and welfare require when designing disaster management programs. This chapter seeks to reimagine human responsibility towards animals for disaster management. The pervasiveness of disasters and their impacts on animals, human-animal and animal-environment relationships underscore the importance of effective animal disaster management supported by sound ethical decision-making processes. To this end, we delineate six ethically responsible animal caretaking aims for consideration when developing disaster management plans and policies. These aims, which address central vulnerabilities experienced by domesticated animals during disasters, are meant to be action-guiding within the disaster management context. They include: (1) Save lives and mitigate harm; (2) Protect animal welfare and respect animals’ experiences; (3) Observe, recognize and promote distributive justice; (4) Advance public involvement; (5) Empower caregivers, guardians, owners and community members; (6) Bolster public health and veterinary community professionalism, including engagement in multidisciplinary teams and applied scientific developments. To bring about these aims, we offer a set of practical and straightforward action steps for animal caregivers and disaster management teams to ensure that animals’ interests are systematically promoted in disaster management. They include: (1) Respect and humane treatment; (2) Collaboration and effective disaster communication; (3) Strengthening systems of information sharing, surveillance, scientific research, management and training; (4) Community outreach and proactive contact; (5) Cultural sensitivity and attitudes check, and (6) Reflection, review and reform.
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"Kelch-Like ECH Associated Protein 1." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_105414.

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M. Owen, John, and Kenneth J. Dormer. "The Shear Stress/KLF2/Nrf2/ARE Pathway: A Hemodynamic Defense against Oxidative Stress." In Blood - Updates on Hemodynamics and Thalassemia. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.99566.

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Many diseases have oxidative stress and inflammation as underlying pathological features, including metabolic and inflammatory/autoimmune disorders, diseases of the lung, liver, kidney, gastrointestinal tract, cardiovascular and nervous systems. A leading physiological mechanism for oxidative stress is the nuclear erythroid-related factor 2-like 2/antioxidant response element (Nrf2/ARE) signaling pathway. It maintains intracellular homeostasis and protects cells from oxidative damage by inducing phase II detoxifying and oxidative-stress responsive genes. Nrf2 transcription factor functions as the key controller of the redox homeostatic gene regulatory network, and is tightly controlled by the repressor protein, Kelch-like ECH-associated protein 1 (Keap1). Pharmacological agents to inhibit Keap1 and boost effectiveness of the Nrf2/ARE pathway have been developed and more are in development. This chapter elucidates the importance of hemodynamic laminar shear stress in oxidative homeostasis and examines hemodynamic induction of the shear stress (SS)/Krupple-like factor2 (KLF2) /Nrf2/ARE pathway as a means to combat oxidative stress through hemodynamics.
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Roos, Noëmi Johanna, Diell Aliu, Jamal Bouitbir, and Stephan Krähenbühl. "Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells." In Updates in Pharmacology. Vide Leaf, Hyderabad, 2020. http://dx.doi.org/10.37247/up.1.2020.13.

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Conference papers on the topic "Kelch-like ECH-associated protein 1"

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Libreros, Stephania, Ramon Garcia-Areas, and Vijaya Iragavarapu-Charyulu. "Abstract 2072: Chitinase-3-like-1 protein expression associated with pulmonary inflammation accelerates metastasis to the lung." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2072.

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Safronova, N. A., T. S. Kurkin, M. B. Shevtsov, et al. "SAMPLE PREPARATION OF A RECEPTOR ASSOCIATED WITH MULTIPLE SCLEROSIS PATHOGENESIS FOR STRUCTURAL STUDIES USING CRYOELECTRON MICROSCOPY." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-370.

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In this work, we study the GPCR class A receptor (rhodopsin-like) which is phylogenetically close to cysteinyl leukotriene and purine receptors. It is expressed in oligodendrocyte progenitor cells and regulates formation of the myelin sheath of neurons. To determine the structure of this receptor by cryoelectron microscopy, we created a stable and monomeric protein sample.
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Libreros, Stephania, Ramon Garcia-Areas, Roberto Carrio, and Vijaya Iragavarapu-Charyulu. "Abstract 2710: Pulmonary inflammation associated with Chitinase-3-like-1 protein (CHI3L1) expression accelerates breast cancer metastasis to the lung." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-2710.

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Beljkas, Milan, Jelena Rebić, Milica Radan, Teodora Đikić, Slavica Oljačić, and Katarina Nikolic. "3D-Quantitative Structure-Activity Relationship and design of novel Rho-associated protein kinases-1 (ROCK1) inhibitors." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.584b.

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Rho-associated coiled-coil kinases (ROCKs) are involved in essential cellular functions such as adhesion, contraction, motility, proliferation, and cell survival/apoptosis. Four ROCK inhibitors have already been approved by the FDA and are used to treat glaucoma (ripasudil and netarsudil), cerebral vasospasm (fasudil), and graft-versus-host disease (belumosudil). Recent studies have focused on exploring the role of ROCK kinase inhibitors in cancer treatment and the development of new ROCK inhibitors. The main objective of this study was to identify critical structural features relevant to the
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Chung, Eunna, and Marissa Nichole Rylander. "Effects of Growth Factors and Stress Conditioning on the Induction of Heat Shock Proteins and Osteogenesis." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206662.

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Tissue engineering is an emerging field that focuses on development of methods for repairing and regenerating damaged or diseased tissue. Successful development of engineered tissues is often limited by insufficient cellular proliferation and insufficient formation of extracellular matrix. To induce effective bone regeneration, many research groups have investigated the cellular response and capability for tissue regeneration associated with bioreactor conditions and addition of growth factors [1]. Bioreactors in tissue engineering have been developed to expose cells to a similar stress enviro
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Ahasic, Amy M., Rihong Zhai, Li Su, et al. "IGFBP3 Polymorphism Is Associated With Plasma Insulin-Like Growth Factor (IGF)-1 And Insulin-Like Growth Factor Binding Protein (IGFBP-3) In An Intensive Care Unit (ICU) Cohort." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3545.

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Mavlianova, Kamilla R., Nikolay B. Orlov, and Vadim V. Klimontov. "Serum Chitinase-3-Like Protein 1 (CHI3L1/YKL-40) is Associated with Diabetic Nephropathy But Not with Glycemic Control or Glucose Variability in Patients with Type 1 Diabetes." In 2023 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine (CSGB). IEEE, 2023. http://dx.doi.org/10.1109/csgb60362.2023.10329854.

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Baker, J. B., M. P. McGrogan, C. Simonsen, R. L. Gronke, and B. W. Festoff. "STRUCTURE AND PROPERTIES OF PROTEASE NEXIN I." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644765.

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Human foreskin fibroblasts secrete several different serine protease inhibitors which differ in size and protease specificities. These proteins, called protease nexins (PNs) all form SDS-resistant complexes with their protease targets. Fibroblast surface receptors recognize the protease-PN complexes and mediate their delivery to lysosomes. PNI is a 45 kilodalton glycoprotein that rapidly inhibits several arg or lys-specific proteases including trypsin, thrombin, and urokinase (k assoc.∼ 4×l06,∼ 6×105 and ∼ 2×105, m−1s−1 respectively). Like antithrombin III, PNI binds heparin and inhibits throm
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Loskutoff, D. J., J. Mimuro, and C. Hekman. "PLASMINOGEN ACTIVATOR INHIBITOR." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644763.

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Plasminogen activation provides an important source of localized proteolytic activity not only during fibrinolysis, but also during ovulation, cell migration, epithelial cell differentiation, tumor invasion and a variety of other physiological processes. Precise regulation of plasminogen activator (PA) activity thus constitutes a critical feature of many biological processes. This control is achieved in large part through the action of specific PA inhibitors (PAIs). Although 4 distinct PAIs have been detected,1the endothelial cellTderived inhibitor (PAI-1) is the only one that efficiently inhi
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Small, G. J., N. R. S. Reddy, and R. Jankowiak. "High Pressure Hole-Burning Studies of Transport Dynamics in Photosynthetic Protein Complex." In Spectral Hole-Burning and Related Spectroscopies: Science and Applications. Optica Publishing Group, 1994. http://dx.doi.org/10.1364/shbs.1994.thd2.

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Hole burning spectroscopies have proven to be powerful tools for the elucidation of the excited state (Qy) electronic structure and transport (energy, charge) dynamics of photosynthetic protein-chlorophyll complexes.1-3 Furthermore, hole burning has proven that such complexes are glass-like on a microscopic scale, which results in inhomogeneous broadenings of ~50-150 cm-1 (ΓI) for the Qy←S0 Chi absorption transitions. Importantly, it has also been shown that the zero-phonon line (ZPL) frequency distribution functions for different Qy-states of the same complex are uncorrelated, meaning that th
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Reports on the topic "Kelch-like ECH-associated protein 1"

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Avni, Adi, and Gitta L. Coaker. Proteomic investigation of a tomato receptor like protein recognizing fungal pathogens. United States Department of Agriculture, 2015. http://dx.doi.org/10.32747/2015.7600030.bard.

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Maximizing food production with minimal negative effects on the environment remains a long-term challenge for sustainable food production. Microbial pathogens cause devastating diseases, minimizing crop losses by controlling plant diseases can contribute significantly to this goal. All plants possess an innate immune system that is activated after recognition of microbial-derived molecules. The fungal protein Eix induces defense responses in tomato and tobacco. Plants recognize Eix through a leucine-rich-repeat receptor- like-protein (LRR-RLP) termed LeEix. Despite the knowledge obtained from
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Gafny, Ron, A. L. N. Rao, and Edna Tanne. Etiology of the Rugose Wood Disease of Grapevine and Molecular Study of the Associated Trichoviruses. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7575269.bard.

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Rugose wood is a complex disease of grapevines, characterized by modification of the woody cylinder of affected vines. The control of rugose wood is based on the production of healthy propagation material. Detection of rugose wood in grapevines is difficult and expensive: budwood from tested plants is grafted onto sensitive Vitis indicators and the appearance of symptoms is monitored for 3 years. The etiology of rugose wood is complex and has not yet been elucidated. Several elongated clostero-like viruses are consistently found in affected vines; one of them, grapevine virus A (GVA), is close
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นุชประยูร, สุรางค์. แผนการวิจัยเรื่อง การศึกษาภูมิคุ้มกันวิทยาเชิงลึกของโรคเท้าช้าง : มุ่งสู่การป้องกันภาวะเท้าช้างและการกำจัดโรคอย่างถาวร : รายงานการวิจัยฉบับสมบูรณ์. จุฬาลงกรณ์มหาวิทยาลัย, 2008. https://doi.org/10.58837/chula.res.2008.25.

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โรคเท้าช้าง (Lymphatic filariasis) เกิดจากพยาธิ 2 ชนิดหลัก คือ Wuchereria bancrofti และ Brugia malayi ทางองค์การอนามัยโลกได้กำหนดให้โรคเท้าช้างเป็นโรคทางปรสิตที่ควรกำจัดให้หมดไปภายในปี พ.ศ. 2563 โดยมีแนวทางหลักในการควบคุมและป้องกันโรคเท้าช้างคือการจัดให้มีโปรแกรมการรักษาแบบหมู่ โดยให้ยา diethylcarbamazine (DEC) ร่วมกับยา albendazole แก่ประชากรในพื้นที่ที่มีความชุกของโรคสูง และการควบคุมพยาธิภาวะ ปัญหาที่สำคัญของการรักษาโรคเท้าช้างคือ การใช้ยา DEC ที่ก่อให้เกิดปฏิกิริยาหลังการรักษา กลไกของการเกิดพยาธิสภาพของโรคและการเกิดปฏิกิริยาหลังการรักษายังไม่เป็นที่ทราบแน่ชัดได้ จึงเป็นอุปสรรคที่สำคัญอย่างย
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4

นุชประยูร, สุรางค์. แผนการวิจัยเรื่อง การศึกษาภูมิคุ้มกันวิทยาเชิงลึกของโรคเท้าช้าง : มุ่งสู่การป้องกันภาวะเท้าช้างและการกำจัดโรคอย่างถาวร : รายงานการวิจัยฉบับสมบูรณ์. จุฬาลงกรณ์มหาวิทยาลัย, 2007. https://doi.org/10.58837/chula.res.2007.23.

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โรคเท้าช้าง (Lymphatic filariasis) เกิดจากหนอนพยาธิ 2 ชนิดหลักคือ Wuchereria bancrofti และ Brugia malayi ทางองค์การอนามัยโลกได้กำหนดให้โรคเท้าช้างเป็นโรคทางปรสิตที่ควรกำจัดให้หมดไปภายในปี พ.ศ. 2563 โดยมีแนวทางหลักในการควบคุมและป้องกันโรคเท้าช้างคือการจัดให้มีโปรแกรมการรักษาแบบหมู่ โดยให้ยา diethylcarbamazine (DEC) ร่วมกับยา albendazole แก่ประชากรในพื้นที่ที่มีความชุกของโรคสูง และการควบคุมพยาธิภาวะ ปัญหาที่สำคัญของการรักษาโรคเท้าช้างคือ การใช้ยา DEC ที่ก่อให้เกิดปฏิกิริยาหลังการรักษา กลไกของการเกิดพยาธิสภาพของโรคและการเกิดปฏิกิริยาหลังการรักษายังไม่เป็นที่ทราบแน่ชัดได้ จึงเป็นอุปสรรคที่สำคัญอย่
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Fromm, A., Avihai Danon, and Jian-Kang Zhu. Genes Controlling Calcium-Enhanced Tolerance to Salinity in Plants. United States Department of Agriculture, 2003. http://dx.doi.org/10.32747/2003.7585201.bard.

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The specific objectives of the proposed research were to identify, clone and characterize downstream cellular target(s) of SOS3 in Arabidopsis thaliana, to analyze the Ca2+-binding characteristics of SOS3 and the sos3-1 mutant and their interactions with SOS3 cellular targets to analyze the SOS3 cell-specific expression patterns, and its subcellular localization, and to assess the in vivo role of SOS3 target protein(s) in plant tolerance to salinity stress. In the course of the study, in view of recent opportunities in identifying Ca2+ - responsive genes using microarrays, the group at Weizman
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Levy, Maggie, Raymond Zielinski, and Anireddy S. Reddy. IQD1 Function in Defense Responses. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7699842.bard.

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The main objective of the proposed research was to study IQD1's mechanism of action and elucidate its role in plant protection. Preliminary experiments suggest that IQD1 binds CaM in a Ca²⁺-dependent manner and functions in general defense responses. We propose to identify proteins and genes that interact with IQD1, which may provide some clues to its mechanism of action. We also plan to dissect IQD1's integration in defense pathways and to study and modulate its binding affinity to CaM in order to enhance crop resistance. Our specific objectives were: (1) Analysis of IQD1's CaM-binding proper
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Sessa, Guido, and Gregory B. Martin. molecular link from PAMP perception to a MAPK cascade associated with tomato disease resistance. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7597918.bard.

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The research problem: The detection of pathogen-associated molecular patterns (PAMPs) by plant pattern recognition receptors (PRRs) is a key mechanism by which plants activate an effective immune response against pathogen attack. MAPK cascades are important signaling components downstream of PRRs that transduce the PAMP signal to activate various defense responses. Preliminary experiments suggested that the receptor-like cytoplasmickinase (RLCK) Mai5 plays a positive role in pattern-triggered immunity (PTI) and interacts with the MAPKKK M3Kε. We thus hypothesized that Mai5, as other RLCKs, fun
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Chalutz, Edo, Charles Wilson, Samir Droby, et al. Induction of Resistance to Postharvest Diseases and Extension of Shelf-Life of Fruits and Vegetables by Ultra-Violet Light. United States Department of Agriculture, 1994. http://dx.doi.org/10.32747/1994.7568093.bard.

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Following preliminary observations by one of the collaborating scientists on this project and the completion of a 1-year, BARD-supported feasibility study (IS-1908-90F), this 3-year BARD project has been executed. The main objectives of the research were to elucidate biochemical and pathological aspects of UV-induced resistance in fruits and vegetables, to characterize physical and biological variables of induced resistance and delay of ripening, and to explore the application of the treatment as a control practice of postharvest diseases and shelf-life extension of fruits and vegetables. Our
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Meir, Shimon, Michael S. Reid, Cai-Zhong Jiang, Amnon Lers, and Sonia Philosoph-Hadas. Molecular Studies of Postharvest Leaf and Flower Senescence. United States Department of Agriculture, 2011. http://dx.doi.org/10.32747/2011.7592657.bard.

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Original objectives: To understand the regulation of abscission by exploring the nature of changes of auxin-related gene expression in tomato (Lycopersicon esculatumMill) abscission zones (AZs) following organ removal, and by analyzing the function of these genes. Our specific goals were: 1) To complete the microarray analyses in tomato flower and leaf AZs, for identifying genes whose expression changes early in response to auxin depletion; 2) To examine, using virus-induced gene silencing (VIGS), the effect of silencing target genes on ethylene sensitivity and abscission competence of the lea
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Avihingsanon, Yingyos, Jongkonnee Wongpiyabovorn, and Nattiya Hirankarn. Biomarker discovery in systemic lupus erythematosus: genome-methylation approaches : Research report. Chulalongkorn University, 2010. https://doi.org/10.58837/chula.res.2010.15.

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Discovery of novel biomarkers in lupus nephritis Biomarkers are needed for making diagnosis and prognosis. In lupus nephritis, conventional tests like urinalysis or serum creatinine remain inadequate for patient care. In this proposal, we focused on non-invasive tools like blood and urine mRNAs or proteins. We chose candidate genes involving regulatory T-cell, B-lymphocyte signatures or vascular protective factors. Expression of regulatory cell signature (FOXP3) in peripheral blood mononuclear cells is associated with activity of lupus nephritis. We found FOXP3 mRNA levels in PBMCs from patien
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