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Dissertations / Theses on the topic 'Kelch-like ECH-associated protein 1'

Author: Grafiati

Published: 5 June 2025

Last updated: 16 July 2025

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1

Tian, Wang, la Vega Montserrat Rojo de, Cody J. Schmidlin, Aikseng Ooi, and Donna D. Zhang. "Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2–related factors 1 and 2 (NRF1 and NRF2)." AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2018. http://hdl.handle.net/10150/627124.

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Nuclear factor erythroid-2-related factor 1 (NRF1) and NRF2 are essential for maintaining redox homeostasis and coordinating cellular stress responses. They are highly homologous transcription factors that regulate the expression of genes bearing antioxidant-response elements (AREs). Genetic ablation of NRF1 or NRF2 results in vastly different phenotypic outcomes, implying that they play different roles and may be differentially regulated. Kelch-like ECH-associated protein 1 (KEAP1) is the main negative regulator of NRF2 and mediates ubiquitylation and degradation of NRF2 through its NRF2-ECH

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2

Nanayakkara, Sachith N. "The role of IGF-1 and hormone binding proteins in understanding insulin-associated equine laminitis." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/118300/1/Sachith_Nanayakkara_Thesis.pdf.

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Laminitis is a common and extremely painful hoof disease in horses. We know that it is caused by abnormally high levels of insulin, but the mechanism of insulin action is not known. One theory is that insulin over-stimulates the receptors for a related hormone, insulin-like growth factor-1, and that this leads to uncontrolled cell proliferation in the hoof, which ultimately causes the disease. The first part of the thesis examines this theory, by determining if insulin can activate IGF-1 receptors directly, or displace IGF-1 from its binding proteins in blood, thereby increasing the activity o

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Hari, Priya. "Identification and study of a role for toll-like receptors in oncogene-induced senescence." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31443.

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Oncogene-induced senescence (OIS) is a fail-safe mechanism activated to halt the proliferation of cells at risk of malignant transformation. It is a cell cycle arrest program of biological changes to the cell comprising of the activation of tumour suppressor pathways, altered cellular metabolism, extensive chromatin remodelling and the activation of a senescence-associated secretory phenotype (SASP). The vast array of proteins secreted by the cells not only play a cell-autonomous role in reinforcing the senescence phenotype, but also modulate the cell's micro-environment by inducing senescence

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4

Bryan, Nicole B. "Subcellular distribution of apoptosis associated speck-like protein mediates inflammasome assembly a novel mechanism in the regulation of interleukin-1beta release /." Morgantown, W. Va. : [West Virginia University Libraries], 2010. http://hdl.handle.net/10450/11239.

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Thesis (Ph. D.)--West Virginia University, 2010.<br>Title from document title page. Document formatted into pages; contains x, 182 p. : ill. (some col.). Includes abstract. Includes bibliographical references.

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5

Kajita, Yoichiro. "The transcription factor Sp3 regulates the expression of a metastasis-related marker of sarcoma, actin filament-associated protein 1-like 1(AFAP1L1)." Kyoto University, 2013. http://hdl.handle.net/2433/179345.

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6

Schulze, Andrea. "A role for the ubiquitin domain protein HERP in ER-associated protein degradation." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2007. http://dx.doi.org/10.18452/15575.

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Die ER-assoziierte Proteindegradation (ERAD) ist Teil des Qualitätskontrollsystems am ER, um der Akkumulation von fehlgefalteten Proteinen im ER entgegenzuwirken. Hierbei werden ERAD-Substrate mit Hilfe von E3-Ligasen wie z.B. HRD1 ubiquityliert und anschließend durch den p97-Ufd1-Npl4 Komplex aus der ER-Membran extrahiert. Im Zytosol werden diese extrahierten Proteine vom 26S Proteasom abgebaut. Für die Retrotranslokation von ERAD- Substraten werden zudem die Membranproteine Derlin-1 und VIMP benötigt, welche mit p97 assoziieren und einen Proteinkomplex bilden. HERP ist ein ER-lo

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7

SEVERA, MARTINA. "Toll-like receptor-mediated induction of type I interferons promotes functional modifications and changing in the gene expression profile along dendritic cell maturation." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/979.

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Le cellule dendritiche (DC) sono considerate le principali cellule presentanti l`antigene per la loro straordinaria capacità di modulare sia la risposta innata che quella adattativa. Il riconoscimento dei patogeni da parte dei Toll-like Receptors (TLR) induce la maturazione delle DC e la successiva produzione di citochine necessarie per la regolazione della risposta immunitaria. Tra le citochine prodotte, gli Interferoni di tipo I (IFN) svolgono un ruolo chiave nella regolazione della risposta immunitaria in quanto, oltre a regolare la proliferazione, differenziamento e maturazione di diverse

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8

Li, Chia-Feng, and 李嘉峰. "The Mechanism of Kelch-Like ECH-Associated Protein 1( Keap1) in Lung Adenocarcinoma Migration." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/54783667330135466675.

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碩士<br>國立臺灣大學<br>毒理學研究所<br>99<br>Kelch-loke ECH-associated protein 1(KEAP1) is a redox-dependent substrate adaptor protein which interact with cul3 ubiquitin ligase complex to degradate NRF2(NF-E2-related factor 2). The decreased expression of KEAP1 will enhance NRF2 expression and accumulate in the nucleus, where binding with antioxidant responsive element(ARE) and activate the antioxidative enzyme expression. Here we observed the KEAP1 expression had inversely correlation with cell migration ability. So we suggesting that the NRF2 target gene may provide advantage for cancer cell progression

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9

Hsieh, Feng-Koo, and 謝逢轂. "The Role of Kelch-Like ECH-Associated Protein 1 (KEAP1) in Lung Adenocarcinoma Migration and Invasion." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/31961946583141266157.

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碩士<br>國立臺灣大學<br>毒理學研究所<br>96<br>Previous studies revealed that weakened KEAP1 (Kelch liked ECH-associated protein 1) expression enhanced NRF2 (NF-E2-related factor 2) nuclear accumulation and elevated antioxidant responsive element (ARE)-mediated induction of phase II detoxifying and oxidative stress enzyme genes such as antioxidative and antixenobiotic stress enzymes and drug efflux pumps in non-small cell lung cancer, suggesting that gave lung cancer cells multiple advantages for proliferation. However, recent studies indicated that NRF2 was not correlated with reduced survival or overall su

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10

Hsieh, Feng-Koo. "The Role of Kelch-Like ECH-Associated Protein 1 (KEAP1) in Lung Adenocarcinoma Migration and Invasion." 2008. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2907200817025900.

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11

Li, Samantha. "Role of Vesicle-associated Membrane Protein 2 in Glucagon-like Peptide-1 Secretion." 2013. http://hdl.handle.net/1807/43079.

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Glucagon-like peptide-1 (GLP-1) is an incretin hormone produced by the enteroendocrine L-cell that potently stimulates insulin secretion. Although signaling pathways promoting GLP-1 secretion are well characterized, the mechanism by which GLP-1 containing granules fuse to the L-cell membrane remain elusive. RT-PCR and protein analysis indicate that vesicle-associated membrane protein 2 (VAMP2) is expressed and localized to secretory granules in the murine GLUTag L-cell model. VAMP2, but not VAMP1, interacted with the core SNARE complex protein, Syntaxin 1a, in GLUTag cells. Tetanus toxin (TetX

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12

Chen, Zih Rong, and 陳姿蓉. "Functional study of enterovirus 71 5'untranslated region associated protein-insulin like growth factor II mRNA binding protein 1（IMP-1）." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/91349537720583535189.

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碩士<br>長庚大學<br>醫學生物技術研究所<br>94<br>Enterovirus 71 utilizes the mechanism of cap-independent translation initiation. This mechanism is initiated by a highly structured RNA within the 5’-untranslated region (5’UTR) of the viral genome. Viral translation rate is influenced by supplementary host and viral trans-acting factors. We identified a set of proteins from neural and non-neural cells to associate with EV71-5’UTR, including insulin-like growth factor II mRNA-binding protein 1 (IMP-1) and 54kDa nuclear RNA- and DNA-binding proteinp54/nrb (p54/nrb). IMP-1 was proved to specifically associate wit

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13

Kumar, Sushant. "Structural Studies on DNA Damage Inducible Protein 1 (Ddi1) of Leishmania and the Rotavirus Nonstructural Protein NSP4." Thesis, 2016. http://etd.iisc.ac.in/handle/2005/3018.

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Structuraj investigations on the Ddi1 (DNA-damage inducible protein 1) of Leishmania major and on the rotavirus nonstructural protein NSP4 were carried out. Ddi1 belongs to the ubiquitin receptor family of proteins. One of its domains is similar to the retroviral aspartic proteinases. It has been shown that this domain is the target of HIV-protease inhibitors that were being used in the treatment of AIDS and it was observed that these drugs effectively controlled opportunistic diseases caused by many parasitic protozoa such as Leishmania and Plasmodium species. The retroviral protease-like dom

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14

Kumar, Sushant. "Structural Studies on DNA Damage Inducible Protein 1 (Ddi1) of Leishmania and the Rotavirus Nonstructural Protein NSP4." Thesis, 2016. http://hdl.handle.net/2005/3018.

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Structuraj investigations on the Ddi1 (DNA-damage inducible protein 1) of Leishmania major and on the rotavirus nonstructural protein NSP4 were carried out. Ddi1 belongs to the ubiquitin receptor family of proteins. One of its domains is similar to the retroviral aspartic proteinases. It has been shown that this domain is the target of HIV-protease inhibitors that were being used in the treatment of AIDS and it was observed that these drugs effectively controlled opportunistic diseases caused by many parasitic protozoa such as Leishmania and Plasmodium species. The retroviral protease-like dom

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15

Yang, Shu-Yuan, and 楊淑媛. "Differential expression of villin 1-like protein associated with remodeling of apical morphologies in the ionocytes of euryhaline medaka, Oryzias dancena." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/19819921676340453677.

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碩士<br>國立中興大學<br>生命科學系所<br>101<br>Different morphologies and functions of gill ionocytes are illustrated in seawater (SW) and fresh water (FW) teleosts. In SW-type ionocytes, the apical membrane invaginates to form a pit exhibited ion secretion. In FW-type ionocytes exhibited ion absorption, the apical membrane is flat with microvilli. Brackish medaka, Oryzias dancena, used as a good species for studies of ionoregulatory mechanisms. In previous studies, the higher gene and protein expressions of VILL determined in the FW-acclimated medaka than in the SW fish. The VILL protein was localized to t

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16

Govender, Nalini. "The role of soluble FMS-like tyrosine-kinase-1, vascular endothelial growth factor and placental growth factor in HIV associated pre-eclamptic pregnancies : a South African perspective." Thesis, 2013. http://hdl.handle.net/10413/9377.

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Introduction and aims. South Africa is the epicenter of the HIV/AIDS pandemic. Hypertensive disorders of pregnancy (15.7%) are the second cause of maternal deaths of which pre-eclampsia represents 83%. Normal pregnancy requires a balance between pro- and anti-angiogenic factors to necessitate effective vasculogenesis, angiogenesis and placental development, however, pre-eclampsia is characterised by an excess anti-angiogenic state. The hypoxic placenta releases excess anti-angiogenic factors into the maternal circulation causing endothelial dysfunction. However, there is no data to verify if H

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