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Journal articles on the topic 'Keratin. Keratinization'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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1

Smack, David Phillips, Bernhard P. Korge, and William D. James. "Keratin and keratinization." Journal of the American Academy of Dermatology 30, no. 1 (1994): 85–102. http://dx.doi.org/10.1016/s0190-9622(94)70012-5.

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2

Dale, B. A., K. A. Holbrook, J. R. Kimball, M. Hoff, and T. T. Sun. "Expression of epidermal keratins and filaggrin during human fetal skin development." Journal of Cell Biology 101, no. 4 (1985): 1257–69. http://dx.doi.org/10.1083/jcb.101.4.1257.

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The major structural proteins of epithelia, the keratins, and the keratin filament-associated protein, filaggrin, were analyzed in more than 50 samples of human embryonic and fetal skin by one-dimensional SDS PAGE and immunoblotting with monoclonal and polyclonal antibodies. Companion samples were examined by immunohistochemistry and electron microscopy. Based on structural characteristics of the epidermis, four periods of human epidermal development were identified. The first is the embryonic period (before 9 wk estimated gestational age), and the others are within the fetal period: stratific

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3

Trachtenberg, S., P. M. Steinert, B. L. Trus, and A. C. Steven. "Paracrystalline Aggregates of Psoriatic Keratin and Their Relation to Normal Keratin Structure." Proceedings, annual meeting, Electron Microscopy Society of America 43 (August 1985): 680–81. http://dx.doi.org/10.1017/s0424820100120096.

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During terminal differentiation of vertebrate epidermis, certain specific keratin intermediate filament (KIF) proteins are produced. Keratinization of the epidermis involves cell death and disruption of the cytoplasm, leaving a network of KIF embedded in an amorphous matrix which forms the outer horny layer known as the stratum corneum. Eventually these cells are shed (desquamation). Normally, the processes of differentiation, keratinization, and desquamation are regulated in an orderly manner. In psoriasis, a chronic skin disease, a hyperkeratotic stratum corneum is produced, resulting in abn

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4

HENDRY, KAY A. K., AMANDA J. MacCALLUM, CHRISTOPHER H. KNIGHT, and COLIN J. WILDE. "Effect of endocrine and paracrine factors on protein synthesis and cell proliferation in bovine hoof tissue culture." Journal of Dairy Research 66, no. 1 (1999): 23–33. http://dx.doi.org/10.1017/s0022029998003288.

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Laminitis is a major cause of lameness in dairy cattle, and is widely attributed to a defect in the horny tissue that gives the hoof its mechanical strength. Defective horn is associated with, and may be preceded by, impaired keratin deposition in the hoof epidermis. The cause of abnormal keratin deposition is not easily identified but, like epidermal keratinization in other tissues, is likely to be controlled by hormones and the paracrine action of locally produced growth factors. The hormonal regulation of keratin synthesis and cell proliferation in the bovine hoof was studied using tissue e

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5

Greenberg, Daniel A., та Douglas S. Fudge. "Regulation of hard α-keratin mechanics via control of intermediate filament hydration: matrix squeeze revisited". Proceedings of the Royal Society B: Biological Sciences 280, № 1750 (2013): 20122158. http://dx.doi.org/10.1098/rspb.2012.2158.

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Mammalian hard α-keratins are fibre-reinforced biomaterials that consist of 10 nm intermediate filaments (IFs) embedded in an elastomeric protein matrix. Recent work suggests that the mechanical properties of IFs are highly sensitive to hydration, whereas hard α-keratins such as wool, hair and nail are relatively hydration insensitive. This raises the question of how mammalian keratins remain stiff in water. The matrix squeeze hypothesis states that the IFs in hard α-keratins are stiffened during an air-drying step during keratinization, and subsequently locked into a dehydrated state via the

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6

Takahashi, K., J. Folmer, and P. A. Coulombe. "Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin." Journal of Cell Biology 127, no. 2 (1994): 505–20. http://dx.doi.org/10.1083/jcb.127.2.505.

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Injury to epidermis and other stratified epithelia triggers profound but transient changes in the pattern of keratin expression. In postmitotic cells located at the wound edge, a strong induction of K6, K16, and K17 synthesis occurs at the expense of the keratins produced under the normal situation. The functional significance of these alterations in keratin expression is not known. Here, we report that overexpression of a wild-type human K16 gene in a tissue-specific fashion in transgenic mice causes aberrant keratinization of the hair follicle outer root sheath and proximal epidermis, and it

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7

Kopan, R., G. Traska, and E. Fuchs. "Retinoids as important regulators of terminal differentiation: examining keratin expression in individual epidermal cells at various stages of keratinization." Journal of Cell Biology 105, no. 1 (1987): 427–40. http://dx.doi.org/10.1083/jcb.105.1.427.

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When human epidermal cells were seeded on floating rafts of collagen and fibroblasts, they stratified at the air-liquid interface. The suprabasal cells synthesized the large type II (K1) and type I (K10/K11) keratins characteristic of terminal differentiation in skin. At earlier times in culture, expression of the large type II keratins appeared to precede the expression of their type I partners. At later times, all suprabasal cells expressed both types, suggesting that the accumulation of a critical level of K1 keratin may be a necessary stimulus for K10 and K11 expression. Expression of the

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8

Bruce Fraser, R. D., Peter M. Steinert, and David A. D. Parry. "Structural changes in trichocyte keratin intermediate filaments during keratinization." Journal of Structural Biology 142, no. 2 (2003): 266–71. http://dx.doi.org/10.1016/s1047-8477(02)00636-6.

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9

Anker, Pálma, Luca Fésűs, Norbert Kiss, et al. "Visualization of Keratin with Diffuse Reflectance and Autofluorescence Imaging and Nonlinear Optical Microscopy in a Rare Keratinopathic Ichthyosis." Sensors 21, no. 4 (2021): 1105. http://dx.doi.org/10.3390/s21041105.

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Keratins are one of the main fluorophores of the skin. Keratinization disorders can lead to alterations in the optical properties of the skin. We set out to investigate a rare form of keratinopathic ichthyosis caused by KRT1 mutation with two different optical imaging methods. We used a newly developed light emitting diode (LED) based device to analyze autofluorescence signal at 405 nm excitation and diffuse reflectance at 526 nm in vivo. Mean autofluorescence intensity of the hyperkeratotic palmar skin was markedly higher in comparison to the healthy control (162.35 vs. 51.14). To further ass

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10

RODRIGUES, JEAN FÁBIO TORRES, and ELOISA AMÁLIA VIEIRA FERRO. "Morphological changes in the vaginal epithelium during the oestrous cycle of Calomys callosus (Rodentia, Cricetidae)." Revista Brasileira de Biologia 58, no. 3 (1998): 527–39. http://dx.doi.org/10.1590/s0034-71081998000300018.

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This study describes changes in the pattern of microridges, keratinization, desquamation, secretion, leukocyte infiltration as well as the increasing number of mitotic cells in the vaginal epithelium of Calomys callosus during the oestrous cycle. In proestrus, the epithelium is squamous and stratified with a fine layer of keratin and it is overlain by secretory prismatic cells. In oestrous, the epithelium is squamous, stratified and keratinized. In metoestrus, the epithelium is squamous and stratified with loss of the keratin layer. A leukocyte infiltration, extending from the base to the surf

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11

Bornschlögl, Thomas, Lucien Bildstein, Sébastien Thibaut, et al. "Keratin network modifications lead to the mechanical stiffening of the hair follicle fiber." Proceedings of the National Academy of Sciences 113, no. 21 (2016): 5940–45. http://dx.doi.org/10.1073/pnas.1520302113.

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The complex mechanical properties of biomaterials such as hair, horn, skin, or bone are determined by the architecture of the underlying fibrous bionetworks. Although much is known about the influence of the cytoskeleton on the mechanics of isolated cells, this has been less studied in tridimensional tissues. We used the hair follicle as a model to link changes in the keratin network composition and architecture to the mechanical properties of the nascent hair. We show using atomic force microscopy that the soft keratinocyte matrix at the base of the follicle stiffens by a factor of ∼360, from

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12

Ouellet, Thérèse, Marc Lussier, Feridoun Babaï, Line Lapointe, and André Royal. "Differential expression of the epidermal K1 and K10 keratin genes during mouse embryo development." Biochemistry and Cell Biology 68, no. 2 (1990): 448–53. http://dx.doi.org/10.1139/o90-063.

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Induction of genes coding for the K1 and K10 keratins during mouse development was studied by measuring the accumulation of their respective mRNAs in day 10 to 17 embryos using an RNase protection assay. Although these two keratins are coexpressed in the suprabasal layers of the epidermis, it was found that while K1 mRNA was detectable as soon as day 10, K10 mRNA was not detectable before day 12. The expression of these genes at this stage of development was not expected since they are specifically associated with keratinization, a process that does not begin before day 17 of gestation. Histol

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13

Nguyen, Ha Thi Thu, Mitsuaki Ono, Emilio Satoshi Hara, et al. "Type XVIII Collagen Modulates Keratohyalin Granule Formation and Keratinization in Oral Mucosa." International Journal of Molecular Sciences 20, no. 19 (2019): 4739. http://dx.doi.org/10.3390/ijms20194739.

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Epithelial keratinization involves complex cellular modifications that provide protection against pathogens and chemical and mechanical injuries. In the oral cavity, keratinized mucosa is also crucial to maintain healthy periodontal or peri-implant tissues. In this study, we investigated the roles of type XVIII collagen, a collagen-glycosaminoglycan featuring an extracellular matrix component present in the basement membrane, in oral mucosal keratinization. Histological analysis of keratinized and non-keratinized oral mucosa showed that type XVIII collagen was highly expressed in keratinized m

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HENDRY, KAY A. K., AMANDA J. MACCALLUM, CHRISTOPHER H. KNIGHT, and COLIN J. WILDE. "Synthesis and distribution of cytokeratins in healthy and ulcerated bovine claw epidermis." Journal of Dairy Research 68, no. 4 (2001): 525–37. http://dx.doi.org/10.1017/s0022029901005052.

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Keratinization of the epidermal cells of the bovine claw generates the horn that gives the tissue its mechanical strength. Disruption of keratinization is likely to have a detrimental effect on the strength and integrity of the horn, and could lead to solar lesions and lameness. As part of a wider investigation of the cell biological causes of lameness in dairy animals, we have compared keratin synthesis and distribution in healthy bovine claw tissue with those in hooves with solar ulcers. Protein synthesis was measured by [35S]-labelled amino acid incorporation in claw tissue explant cultures

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15

Hashimoto, Ken, Yoichiro Toi, Sharon Horton, and Tung-Tien Sun. "Spiny keratoderma - a demonstration of hair keratin and hair type keratinization." Journal of Cutaneous Pathology 26, no. 1 (1999): 25–30. http://dx.doi.org/10.1111/j.1600-0560.1999.tb01786.x.

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16

Avril, Mondell, and Cheryl Riley. "Management of Epidermolytic Ichthyosis in the Newborn." Neonatal Network 35, no. 1 (2016): 19–30. http://dx.doi.org/10.1891/0730-0832.35.1.19.

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AbstractEpidermolytic ichthyosis (EI) is a rare autosomal dominant genodermatosis that presents at birth as a bullous disease, followed by a lifelong ichthyotic skin disorder.1 Essentially, it is a defective keratinization caused by mutations of keratin 1 (KRT1) or keratin 10 (KRT10) genes, which lead to skin fragility, blistering, and eventually hyperkeratosis. Successful management of EI in the newborn period can be achieved through a thoughtful, directed, and interdisciplinary or multidisciplinary approach that encompasses family support. This condition requires meticulous care to avoid ass

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17

Lalošević, Jovan, Mirjana Gajić-Veljić, Jelena Stojković-Filipović, Martina Bosić, and Miloš Nikolić. "Pachyonychia Congenita - Can a Specific Phenotype be a Clue to a Genetic Defect? - a Case Report and Literature Review." Serbian Journal of Dermatology and Venereology 9, no. 3 (2017): 119–23. http://dx.doi.org/10.1515/sjdv-2017-0012.

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Abstract Pachyonychia congenita (PC) is a rare inherited disorder of keratinization characterized by hypertrophic nail dystrophy, painful palmoplantar blisters, cysts, follicular hyperkeratosis and oral leukokeratosis. These pathological clinical features are resulting from mutations in keratin proteins including KRT6A, KRT6B, KRT6C, KRT16, and KRT17. We present a 6-year-old girl with hypertrophic nail dystrophy, follicular hyperkeratosis, circumscribed plantar keratoderma and oral leukokeratosis. The features were consistent with the diagnosis of PC. The patient has been registered in the Int

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18

Maia, Rafael, Regina H. F. Macedo, and Matthew D. Shawkey. "Nanostructural self-assembly of iridescent feather barbules through depletion attraction of melanosomes during keratinization." Journal of The Royal Society Interface 9, no. 69 (2011): 734–43. http://dx.doi.org/10.1098/rsif.2011.0456.

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Avian plumage colours are model traits in understanding the evolution of sexually selected ornamental traits. Paradoxically, iridescent structural colours, probably the most dazzling of these traits, remain the most poorly understood. Though some data suggest that expression of bright iridescent plumage colours produced by highly ordered arrays of melanosomes and keratin is condition-dependent, almost nothing is known of their ontogeny and thus of any developmental mechanisms that may be susceptible to perturbation. Here, we use light and electron microscopy to compare the ontogeny of iridesce

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19

Das, Dev Kumar, Chandan Chakraborty, Satyakam Sawaimoon, Asok Kumar Maiti, and Sanjoy Chatterjee. "Automated identification of keratinization and keratin pearl area from in situ oral histological images." Tissue and Cell 47, no. 4 (2015): 349–58. http://dx.doi.org/10.1016/j.tice.2015.04.009.

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20

Rentrop, M., B. Knapp, H. Winter, and J. Schweizer. "Differential localization of distinct keratin mRNA-species in mouse tongue epithelium by in situ hybridization with specific cDNA probes." Journal of Cell Biology 103, no. 6 (1986): 2583–91. http://dx.doi.org/10.1083/jcb.103.6.2583.

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The tongue of the adult mouse is covered by a multilayered squamous epithelium which is continuous on the ventral surface, however interrupted on the dorsal surface by many filiform and few fungiform papillae. The filiform papillae themselves are subdivided into an anterior and posterior unit exhibiting different forms of keratinization. Thus, the entire epithelium shows a pronounced morphological diversity of well recognizable tissue units. We have used a highly sensitive in situ hybridization technique to investigate the differential expression of keratin mRNAs in the tongue epithelium. The

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21

Panteleyev, Andrei A., Renate Thiel, Reinhard Wanner, et al. "2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Affects Keratin 1 and Keratin 17 Gene Expression and Differentially Induces Keratinization in Hairless Mouse Skin." Journal of Investigative Dermatology 108, no. 3 (1997): 330–35. http://dx.doi.org/10.1111/1523-1747.ep12286478.

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22

Wei, Shuanzeng, and Hormoz Ehya. "Degenerated Keratinized Tumor Cells in Oropharyngeal Human Papilloma Virus-Associated Squamous Cell Carcinoma: A Pitfall in p16 Immunostaining of Fine-Needle Aspiration Specimens." Acta Cytologica 62, no. 5-6 (2018): 339–45. http://dx.doi.org/10.1159/000490229.

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Objective: High-risk human papilloma virus (HPV) testing should be performed on all patients with newly diagnosed oropharyngeal HPV-associated squamous cell carcinoma (OPHPVSCC), and p16 immunostaining can be used as a surrogate marker. Although in surgical pathology specimens p16 staining in > 70% of the tumor cells is considered a positive result, the interpretation in fine-needle aspiration (FNA) specimens has remained controversial. Study Design: FNA of neck lymph nodes and corresponding surgical specimens from 42 patients with OPHPVSCC were reviewed. Results: In FNA specimens, 38 cases

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23

Winkler, B., J. K. Margerison, and C. Brennan. "The use of texture analysis to assess the structural strength of hoof horn of dairy cows." Proceedings of the British Society of Animal Science 2001 (2001): 171. http://dx.doi.org/10.1017/s1752756200005536.

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The quality of hoof horn is related to 3 factors: architecture of the Stratum corneum (number of tubules and inter-tubular space), cellular factors (type of keratinization, orientation of keratin fibres) and inter-cellular factors (amount and chemical composition of the inter-cellular substance (Pellman et al., 1993). Kempson and Logue (1993) related poor hoof horn quality at 1 month before calving to the occurrence of moderate to severe solar haemorrhage at 10 to 20 weeks after calving. The objective of this experiment was to develop the use of texture analysis as a method to measure the stru

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24

Metze, Dieter, Heiko Traupe, and Kira Süßmuth. "Ichthyoses—A Clinical and Pathological Spectrum from Heterogeneous Cornification Disorders to Inflammation." Dermatopathology 8, no. 2 (2021): 107–23. http://dx.doi.org/10.3390/dermatopathology8020017.

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Ichthyoses are inborn keratinization disorders affecting the skin only (non-syndromic) or are associated with diseases of internal organs (syndromic). In newborns, they can be life-threatening. The identification of the gene defects resulted in reclassification and a better understanding of the pathophysiology. Histopathologic patterns include orthohyperkeratosis with a reduced or well-developed stratum granulosum, hyperkeratosis with ortho- and parakeratosis with preserved or prominent stratum granulosum, and epidermolytic ichthyosis. Another pattern features “perinuclear vacuoles and binucle

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25

Diociaiuti, Andrea, Daniele Castiglia, Marialuisa Corbeddu, et al. "First Case of KRT2 Epidermolytic Nevus and Novel Clinical and Genetic Findings in 26 Italian Patients with Keratinopathic Ichthyoses." International Journal of Molecular Sciences 21, no. 20 (2020): 7707. http://dx.doi.org/10.3390/ijms21207707.

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Keratinopathic ichthyoses (KI) are a clinically heterogeneous group of keratinization disorders due to mutations in KRT1, KTR10, or KRT2 genes encoding keratins of suprabasal epidermis. Characteristic clinical features include superficial blisters and erosions in infancy and progressive development of hyperkeratosis. Histopathology shows epidermolytic hyperkeratosis. We describe the clinical, histopathological, and molecular findings of a series of 26 Italian patients from 19 unrelated families affected with (i) epidermolytic ichthyosis due to KRT1 or KRT10 mutations (7 and 9 cases, respective

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26

Vijayasaradhi, S., and P. D. Gupta. "Keratinization of rat vaginal epithelium. II. Immunofluorescence study on keratin filaments in cycling and estrogen primed rats." Journal of Biosciences 13, no. 2 (1988): 109–16. http://dx.doi.org/10.1007/bf02903091.

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27

Al-Eryani, Kamal, Jun Cheng, Tatsuya Abé, et al. "Hemophagocytosis-mediated keratinization in oral carcinoma in situ and squamous cell carcinoma: A possible histopathogenesis of keratin pearls." Journal of Cellular Physiology 228, no. 10 (2013): 1977–88. http://dx.doi.org/10.1002/jcp.24364.

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28

Rabelo, R. E., V. A. S. Vulcani, F. J. F. Sant'ana, et al. "Histomorphological evaluation of the digital coronary region at different fetal development stages of Holstein cattle." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 67, no. 1 (2015): 1–6. http://dx.doi.org/10.1590/1678-7529.

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The scientific literature lacks detailed morphological descriptions of the histological development and cell differentiation of fetal bovine hoof. In this study, 40 extremity members of Holstein bovine fetuses were collected and divided into four groups (G1 to G4) based on the estimated age. Fragments were removed from wall and sole, processed and stained with hematoxylin - eosin (HE) for light microscopy observation. In G1, it was found that the epidermis was very thin, including keratinocyte layers and clusters of mesenchymal cells. In group G2 it was observed that the thickness of the epide

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Mak-Kregar, Sanja, Wolter J. Mooi, Alfons J. M. Balm, and Frans J. M. Hilgers. "Squamous cell carcinoma of the tonsillar region and the base of the tongue: a morphological and immunohistochemical comparative pilot study." Journal of Laryngology & Otology 107, no. 12 (1993): 1129–35. http://dx.doi.org/10.1017/s0022215100125472.

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Sixteen squamous cell carcinomas of the tonsillar region and 13 carcinomas of the base of the tongue were studied in a search for significant differences between the tumours of these two oropharyngeal subsites, which are known to carry a significantly different prognosis. The characteristics of the tumour cells and the tumourhost relationship were scored on H & E-stained slides, as well as on slides stained with a panel of antibodies. The results obtained were cross-tabulated and analysed with respect to the subsite. Ten variables were tested: cytonuclear pleomorphism, mitotic activity, th

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30

KALDRYMIDOU (Ε. ΚΑΛΔΡΥΜΙΔΟΥ), E., G. KANAKOUDIS (Γ. ΚΑΝΑΚΟΥΔΗΣ), Th TOLIOU (Θ. ΤΟΛΙΟΥ), Th POUTAHIDIS (Θ. ΠΟΥΤΑΧΙΔΗΣ), and M. KARAGIANNOPOULOU (Μ. ΚΑΡΑΓΙΑΝΝΟΠΟΥΛΟΥ). "Squamous cell carcinoma of the dog." Journal of the Hellenic Veterinary Medical Society 50, no. 3 (2018): 250. http://dx.doi.org/10.12681/jhvms.15718.

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Squamous cell carcinoma is the most common skin neoplasm with cellular evidence of malignancy. Neoplastic cells preserve characteristics of the stratum spinosum and infiltrate dermis. Squamous cell carcinomas classification is based on the degree of cell differentiation and tumor architecture and includes more than one categories. Immunohistochemistry is often applied in order to distinguish this carcinoma from other epithelial neoplasms. In the present study four squamous cell carcinomas of the dog were examined and classified. Three of them (2,3,4) presented low rates of differentiation so,

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Nakhoul, Nazih L., Chia-Ling Tu, Karen L. Brown, M. Toriqul Islam, Anna G. Hodges, and Solange M. Abdulnour-Nakhoul. "Calcium-sensing receptor deletion in the mouse esophagus alters barrier function." American Journal of Physiology-Gastrointestinal and Liver Physiology 318, no. 1 (2020): G144—G161. http://dx.doi.org/10.1152/ajpgi.00021.2019.

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Calcium-sensing receptor (CaSR) is the molecular sensor by which cells respond to small changes in extracellular Ca2+ concentrations. CaSR has been reported to play a role in glandular and fluid secretion in the gastrointestinal tract and to regulate differentiation and proliferation of skin keratinocytes. CaSR is present in the esophageal epithelium, but its role in this tissue has not been defined. We deleted CaSR in the mouse esophagus by generating keratin 5 CreER;CaSRFlox+/+compound mutants, in which loxP sites flank exon 7 of CaSR gene. Recombination was initiated with multiple tamoxifen

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HUNTER, I., та D. SKERROW. "Relationship of the final α-keratin compositions in dyskeratoses to those along the normal keratinization pathway: aetiological and diagnostic significance". British Journal of Dermatology 120, № 3 (1989): 363–69. http://dx.doi.org/10.1111/j.1365-2133.1989.tb04161.x.

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Coulombe, Pierre A., Nicola S. Bravo, Rudolph D. Paladini, Diem Nguyen, and Kenzo Takahashi. "Overexpression of human keratin 16 produces a distinct skin phenotype in transgenic mouse skin." Biochemistry and Cell Biology 73, no. 9-10 (1995): 611–18. http://dx.doi.org/10.1139/o95-067.

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Human cytokeratin 16 (K16; 48 kDa) is constitutively expressed in postmitotic keratinocytes in a variety of stratified epithelial tissues, but it is best known for the marked enhancement of its expression in stratified squamous epithelia showing hyperproliferation or abnormal differentiation. Of particular interest to us, K16 is strongly induced at the wound edge after injury to the epidermis, and its accumulation correlates spatially and temporally with the onset of reepithelialization. To examine the properties of K16 in its natural cellular context, we introduced a wild-type human K16 gene

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Hendry, Kay AK, Christopher H. Knight, Hugh Galbraith, and Colin J. Wilde. "Basement membrane integrity and keratinization in healthy and ulcerated bovine hoof tissue." Journal of Dairy Research 70, no. 1 (2003): 19–27. http://dx.doi.org/10.1017/s0022029902005885.

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Damage to, or deterioration of, the keratinized horn tissue of the bovine hoof claw culminates ultimately in the development of solear ulceration. We have observed abnormal keratin distribution at the site of solear ulceration in the bovine claw that may be due to alteration of the positional cues of the keratinocytes. In this study we have characterized key cell biological changes associated with ulceration in the claw that may precipitate abnormal keratinization. Loss of basement membrane at sites of ulceration was found by immunofluorescent detection of laminin and integrins. In other tissu

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Corcoran, J. S., C. W. I. Owens, and J. S. Yudkin. "Measurement of fingertip blood flow using thermal clearance reflects anastomotic rather than nutrient blood flow." Clinical Science 72, no. 2 (1987): 225–32. http://dx.doi.org/10.1042/cs0720225.

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1. A thermal clearance probe was used to measure fingertip blood flow. When flow was occluded the baseline value was reproducible (coefficient of variation 2% between subjects), whereas basal and maximum flow were poorly reproducible even within subjects. 2. Synchronous changes in thermal clearance were seen when two probes were used on fingers and toes of different limbs (r = 0.77–0.97), in keeping with a central control mechanism. 3. Fingertip blood flow, as measured by thermal clearance, correlated with Po2 of venous blood draining from the dorsum of the hand (r = 0.72–0.92). 4. Contralater

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Crowe, David L., Lan Hu, Lorraine J. Gudas та James G. Rheinwald. "Variable expression of retinoie acid receptor (RARβ) mRNA in human oral and epidermal keratinocytes; relation to keratin 19 expression and keratinization potential". Differentiation 48, № 3 (1991): 199–208. http://dx.doi.org/10.1111/j.1432-0436.1991.tb00258.x.

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Hussin, Amer M., Nazih W. Zaid, and S. O. Hussain. "Compensatory Structural Adaptive Modifications of Vagina in Response to Functional Demand in Goat." Veterinary Medicine International 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/789816.

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Vaginal biopsies and smears were collected from ten adult local healthy goats. Routine histological methods were carried out on vaginal biopsies and then stained with PAS stain. The smears were stained with Methylene blue. All samples were inspected under light microscope. The present study found that many constituents of the wall of the vagina, which have an important functional role, were absent; among these were the vaginal glands, goblet cells, muscularis mucosa, and lymphatic nodules. On the other hand, vagina showed special compensatory histological mechanisms, namely, the deep epithelia

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Schön, Margarete, та James G. Rheinwald. "A Limited Role for Retinoic Acid and Retinoic Acid Receptors RARα and RARβ in Regulating Keratin 19 Expression and Keratinization in Oral and Epidermal Keratinocytes". Journal of Investigative Dermatology 107, № 3 (1996): 428–38. http://dx.doi.org/10.1111/1523-1747.ep12363411.

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Ullah, A., S. Heneidi, P. Biddinger, et al. "Paraneoplastic Limbic Encephalitis Secondary To Mixed Non-Seminomatous Germ Cell Tumours." American Journal of Clinical Pathology 154, Supplement_1 (2020): S55—S56. http://dx.doi.org/10.1093/ajcp/aqaa161.119.

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Abstract Casestudy: Testicular tumors account for 1–2% of all tumors in men, with 95% of these being germ cell tumors. The main risk factor for the development of testicular cancer is cryptorchidism. Paraneoplastic limbic encephalitis is a rare sequela of testicular tumor associated with anti-Ma2 and KLH11 antibodies. The most effective treatment for paraneoplastic limbic encephalitis is treatment of the primary malignancy. We present a 41-year-old male that presented to the emergency department with two weeks of episodic alteration of consciousness and memory disturbances. Negative neurologic

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Laskin, Jeffrey D. "Keratinization and Tumor Promotion." Journal of the American College of Toxicology 8, no. 2 (1989): 245–51. http://dx.doi.org/10.3109/10915818909019548.

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Keratins are the major proteins synthesized by keratinocytes. They consist of a group of 10–20 different polypeptides in the molecular weight range of 48,000–67,000. Keratins associate in cells to form intermediate filaments, the major network of the keratinocyte cytoskeletal architecture. Keratins are produced in cells in a specific, sequential manner during epidermal stratification and the formation of the stratum corneum. Tumor promotion in mouse skin is associated with epidermal hyperplasia and aberrant cellular differentiation. This is accompanied by alterations in normal patterns of kera

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Kim, Woo Sik, Jeong Hun Seo, Jae-In Lee, et al. "The Metabolite Profile in Culture Supernatant of Aster yomena Callus and Its Anti-Photoaging Effect in Skin Cells Exposed to UVB." Plants 10, no. 4 (2021): 659. http://dx.doi.org/10.3390/plants10040659.

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Aster yomena (A. yomena) extract has anti-inflammatory, antioxidant, anti-asthma, and anti-atopic effects. However, the commercial use of A. yomena extract requires a long processing time with specific processing steps (including heat treatment and ethanol precipitation), and there are various environmental problems. We aimed to build a system to produce A. yomena extract by culturing the callus in a bioreactor that can allow rapid process scale-up to test the effect of extract (AYC-CS-E) isolated from culture supernatant of A. yomena callus on photoaging of human keratinocytes (HaCaT) caused

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Agustina, Dewi, and Goeno Subagyo. "Exfoliative Cheilitis dan Penatalaksanaannya." Majalah Kedokteran Gigi Indonesia 19, no. 1 (2012): 49. http://dx.doi.org/10.22146/majkedgiind.15677.

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Latar Belakang: Exfoliative cheilitis adalah suatu keadaan inflamatori kronis superfisisal yang ditandai dengan adanya pengelupasan permukaankeratin bibir sedangkan area yang lain terjadi pembentukan lapisan keratin. Tujuan: untuk melaporkan suatu kasus Exfoliative cheilitis yang diikuti + selama 2 bulan beserta penatalaksanaanya. Laporan kasus: seorang wanita berusia 52 tahun mengeluh bibir bawahnya pecah-pecah, terasa kering dan panas berdasarkan pemeriksaan subyektif dan klinis, Exfoliative cheilitis ditetapkan sebagai diagnosis kerja. Penatalaksanaanya: Komunikasi-Informasi-Edukasi (KIE) d

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Hynd, P. I. "The nutritional biochemistry of wool and hair follicles." Animal Science 70, no. 2 (2000): 181–95. http://dx.doi.org/10.1017/s1357729800054655.

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AbstractThe rôle of various classes of nutrients (energy substrates, vitamins, minerals, amino acids) in the production of wool and hair from follicles, is considered for a variety of animal species. The wool and hair follicle have evolved a number of interesting features of carbohydrate metabolism including glutaminolysis, aerobic glycolysis, significant activity of the pentose phosphate pathway, and storage and mobilisation of glycogen. Presumably the necessity to continue to produce fibre despite fluctuations in the supply of oxygen and nutrients has resulted in some of these unique feature

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Boukamp, P., R. T. Petrussevska, D. Breitkreutz, J. Hornung, A. Markham, and N. E. Fusenig. "Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line." Journal of Cell Biology 106, no. 3 (1988): 761–71. http://dx.doi.org/10.1083/jcb.106.3.761.

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In contrast to mouse epidermal cells, human skin keratinocytes are rather resistant to transformation in vitro. Immortalization has been achieved by SV40 but has resulted in cell lines with altered differentiation. We have established a spontaneously transformed human epithelial cell line from adult skin, which maintains full epidermal differentiation capacity. This HaCaT cell line is obviously immortal (greater than 140 passages), has a transformed phenotype in vitro (clonogenic on plastic and in agar) but remains nontumorigenic. Despite the altered and unlimited growth potential, HaCaT cells

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Grachtchouk, Marina, Jianhong Liu, Mark E. Hutchin, et al. "Constitutive Hedgehog/GLI2 signaling drives extracutaneous basaloid squamous cell carcinoma development and bone remodeling." Carcinogenesis 42, no. 8 (2021): 1100–1109. http://dx.doi.org/10.1093/carcin/bgab050.

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Abstract Uncontrolled activation of the Hedgehog (Hh) signaling pathway, operating through GLI transcription factors, plays a central role in the pathogenesis of cutaneous basal cell carcinoma and contributes to the development of several malignancies arising in extracutaneous sites. We now report that K5-tTA;tetO-Gli2 bitransgenic mice develop distinctive epithelial tumors within their jaws. These tumors consist of large masses of highly proliferative, monomorphous, basaloid cells with scattered foci of keratinization and central necrosis, mimicking human basaloid squamous cell carcinoma (BSC

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Travaglino, Antonio, Antonio Raffone, Daniela Russo, et al. "Does endometrial morular metaplasia represent odontogenic differentiation?" Virchows Archiv, March 5, 2021. http://dx.doi.org/10.1007/s00428-021-03060-2.

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AbstractThe nature of endometrial morular metaplasia (MorM) is still unknown. The nuclear β-catenin accumulation and the not rare ghost cell keratinization suggest a similarity with hard keratin-producing odontogenic and hair matrix tumors rather than with squamous differentiation. We aimed to compare MorM to hard keratin-producing tumors. Forty-one hard keratin-producing tumors, including 26 hair matrix tumors (20 pilomatrixomas and 6 pilomatrix carcinomas) and 15 odontogenic tumors (adamantinomatous craniopharyngiomas), were compared to 15 endometrioid carcinomas with MorM with or without sq

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Ohata, Yae, Rei Tohyama, Kou Kayamori, et al. "A Rare Cancer of the Tongue That Showed Unusual Histology and Immunohistochemical Phenotype: Case Report." UI Proceedings on Health and Medicine 1 (January 3, 2017). http://dx.doi.org/10.7454/uiphm.v1i0.50.

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<p class="AbstractContent">We report a rare case of primary tongue cancer that showed unusual clinical, histological and immunohistological features. The patient was a 73-year-old man who presented with a submucosal tumor in the left side of tongue. Treatment consisted of preoperative chemotherapy, hemiglossectomy, unilateral neck dissection and postoperative chemo-radiotherapy. The tumor locates in the submucosa, independently of the overlying tongue epithelium and the salivary gland. The tumor showed infiltrating growth, arranged in cord or trabecular nests without keratinization or di

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Komori, Taishi, Mitsuaki Ono, Emilio Satoshi Hara та ін. "Type IV collagen α6 chain is a regulator of keratin 10 in keratinization of oral mucosal epithelium". Scientific Reports 8, № 1 (2018). http://dx.doi.org/10.1038/s41598-018-21000-0.

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Barbosa, Francisca Maria Sousa, Natanael Félix Silva Filho, Tolentino Lira Alcântra, et al. "Adenosquamous carcinoma of the cervical oesophagus in a dog." Ciência Rural 50, no. 7 (2020). http://dx.doi.org/10.1590/0103-8478cr20190788.

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ABSTRACT: A 9-year-old male Shih Tzu dog presented with a mass on the ventral region of the neck and developed ptyalism. Radiographs revealed a radiodense nodule located in the mid-third of the oesophagus compressing the trachea. Preoperative cytology showed large neoplastic cells with abundant vacuolated cytoplasm arranged in clusters. The nodule was removed by oesophagectomy and submitted for histopathology. Microscopically, the oesophageal mass was multilobulated and unencapsulated. It had a mixed cellular growth pattern with areas showing squamous and glandular differentiation. The squamou

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Shames, RoseB, LorenW Knapp, WayneE Carver, LynetteD Washington, and RogerH Sawyer. "Keratinization of the outer surface of the avian scutate scale: Interrelationship of alpha and beta keratin filaments in a cornifying tissue." Cell and Tissue Research 257, no. 1 (1989). http://dx.doi.org/10.1007/bf00221637.

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